US3814095A - Occlusively applied anesthetic patch - Google Patents

Occlusively applied anesthetic patch Download PDF

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Publication number
US3814095A
US3814095A US00237712A US23771272A US3814095A US 3814095 A US3814095 A US 3814095A US 00237712 A US00237712 A US 00237712A US 23771272 A US23771272 A US 23771272A US 3814095 A US3814095 A US 3814095A
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US
United States
Prior art keywords
anesthetic
skin
patch
pad means
anesthetic agent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00237712A
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English (en)
Inventor
H Lubens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LUBENS-RICHMAN CLINICAL ASTHMA ALLERGY AND IMMUNOLOGY FUND
WRIGHT STTE UNIVERSITY A BODY POLITIC AND CORPORATE OF OH
Wright State University
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority to US00237712A priority Critical patent/US3814095A/en
Priority to CA166,704A priority patent/CA1015660A/en
Priority to DE19732314509 priority patent/DE2314509A1/de
Priority to GB1415073A priority patent/GB1408079A/en
Priority to JP48034020A priority patent/JPS498091A/ja
Application granted granted Critical
Publication of US3814095A publication Critical patent/US3814095A/en
Assigned to WRIGHT STTE UNIVERSITY, A BODY POLITIC AND CORPORATE OF OH reassignment WRIGHT STTE UNIVERSITY, A BODY POLITIC AND CORPORATE OF OH ASSIGNMENT OF A PART OF ASSIGNORS INTEREST Assignors: LUBENS, HERMAN M.
Anticipated expiration legal-status Critical
Assigned to LUBENS-RICHMAN CLINICAL ASTHMA, ALLERGY AND IMMUNOLOGY FUND, WRIGHT STATE UNIVERSITY FOUNDATION INC. reassignment LUBENS-RICHMAN CLINICAL ASTHMA, ALLERGY AND IMMUNOLOGY FUND ASSIGNMENT OF A PART OF ASSIGNORS INTEREST 80.0 PERCENT Assignors: LUBENS, HERMAN M., M.D.
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00—Local anaesthesia; Hypothermia

Definitions

  • ABSTRACT An adhesively applied patch for topical application to intact skin for producing effective anesthesia for varying amounts of time depending upon the extent of time the patch is applied.
  • the patch includes an occlusive member mounted on an adhesive backing, the topical anesthetic agent being on a gauze-like pad received within the occlusive member such that penetra- -tion of theanesthetic agent into intact skin is enhanced.
  • the anesthetic agent is preferably the amino- 1,920,808 8/1933 Sunder 128/ 154 acyl amide type and virtually nonallergnic.
  • 128/268 X uses of such a patch are intradermal allergen skin l t- 2,344,021 BOUZlflIIC ing lunbar punctures kin biopsies and minor urgical 2,579,403 12/1951 Slomowitz et a1.
  • 128/268 procedures 9 3,062,210 11/1962 Scholl 128/156 3,212,495 10/1965 Osbourn et a1.
  • the present invention is directed to an improved skin patch which quickly and efficiently anesthetizes intack skin and abolishes the pain incident to various medical procedures suchas needle injections.
  • the invention provides for pressing a pad of gauze-like material saturated with an anesthetic agent against the intact skin for the purpose of producing anesthesia in intact skin.
  • the skin patch is sandwiched against an adhesive tape or other skin adhcrent material and includes an occlusive member, generally' annular in shape and which is raised. Received within the occlusive member is a guaze-like pad saturated with an anesthetic agent, the adhesive backing operating to hold the gauze pad in place.
  • the occlusive member When the patch is applied to intact skin, the occlusive member is effectively sealed to the skin tending to press the gauze pad and the anesthetic agent against the skin for the purpose of increasing the rate of penetration of the anesthetic agent into the skin.
  • the peripheral edge portions of the gauze pad are coated or impregnated with a blue skin coloring material which is transferred to the skin and which provides a frame-like outline of the skin area under anethesia, once the patch is removed.
  • the basic concept of the invention may be utilized in a multiple patch, wherein a plurality ofthe patches are sandwiched between a large sheet of skin adherent material and a large sheet of overlying protective material, for example for use in intradermal allergen skin testing. Additionally, the large sheets of base material and overlying material may be perforated so that a unitary patch may be separated one at a time.
  • Another form of the invention which facilitates dispensing of such patches, includes a continuous strip in convoluted roll form of plastic overlying material enclosing individual sections of separable patches.
  • FIG. 1 is a perspective view of an occlusively applied anesthetic skin patch constructed according to the present invention
  • FIG. 2 is an exploded view of the skin patch of FIG.
  • FIG. 3 is across-sectional view of the skin patch of FIG. 1 applied to intact skin;
  • FIG. 4 is a perspective view of a multiple patch having a plurality of skin patches sandwiched between a thin plastic overlying sheet and a large strip of tape skin adherent;
  • FIG. 5 is an exploded view showing a plurality of skin patches applied to perforated pieces of skin adherent and protected by a perforated overlying sheet of thin plastic material;
  • FIG. 6 is a perspective view showing a roll of individualized skin patches applied to a continuous strip of overlying plastic material
  • FIG. 7 is a schematic view of a multiple patch applied to the upper arm of an individual.
  • FIG. 8 is a schematic view of the upper arm of FIG. 7 after the multiple patch has been removed, and showing the multiple anesthetized sites framed by marking material transferred onto the upper arm by the patch material.
  • the anesthetic skin patch 10 of the present invention comprises occlusive means consisting of an annular resilient member 12 adhered to an adhesive coated backing member 14 to form therewith a shallow cup-like space. That portion 16 of the adhesive member 14 overlying the occlusive member 12 is impermeable.
  • the adhesive member 14 is larger insurface area than the occlusive member 12 so that when the patch 10 is applied to the skin (FIG. 3), the occlusive member 12 is held firmly in contact and effectively seals against the skin.
  • the gauzelike pad 25 is preferably a porous gauze material capable of absorbing a liquid or cream anesthetic for topically anesthetizing intact skin.
  • the peripheral edges 29 of the gauze pad 25 are preferably marked with a blue skin marking crayon (cross-hatching) so that, after the pad is removed to the skin, the anesthetized site will be quickly apparent.
  • Lidocaine also known as Xylocaine, and having the chemical name 2-di ethylar nino-2 o -aceto-xylidide. is a useful topical infiltration, nerve block, spinal, peri dural and caudal anesthetic. It is particularly useful in connection with the present invention, because a 10 --50 percent Lidocaine cream formulation is useful in inducing anesthesia in intack skin. A 30 percent Lidocaine cream formulation, for example, will anesthetize adjacent skin when in contact for twenty to thirty minutes. A typical such formulation contains the following constituents:
  • the occlusive member 12 and guaze pad 25 are so proportioned that when the patch is applied to the intact skin (FIG. 3), by adhesive member 14, the occlusive member 12 is pressed against the skin, and the gauze-like pad is pressed against the skin which action increases the rate of skin penetration by the anesthetic agent within the pad. Consequently, the intact skin is insensitized more quickly than has heretofore been possible.
  • This effectiveness of the anesthetic patch depends on (1) high concentration percent Lidocaine, (2) a suitable vehicle, (3) an adequate period of application (30 minutes or more), and (4) an occlusive dressing.
  • the gauge piecafiay be in varToussiEs and shapes as required'for the contemplated procedure.
  • the area is cleansed with acetone and alcohol.
  • the gauze on the anesthetic patch is saturated with the anesthetic cream.
  • the anesthetic patch is then applied to the intake skin area.
  • the anesthetic patch is removed after the required period of 30 minutes or more at the area where the patch was applied, which is then clearly demarcated by a blue border. This area is completely anesthetized in preparation for a painful procedure.
  • a plurality of skin patches may be used on a single sheet of skin adherent material.
  • a multiple patch 30 has a plurality of skin patches 10 mounted with their recessed ends against a base sheet of skin adherent material such as tape.
  • Each of the skin patches 10 carries a pad saturated with the anesthetic agent, and the edges 36 of each of the pads may be marked with a blue skin coloring marking material.
  • the multiple patch sheet is covered by a plastic sheet 38 of larger dimension than the sheet 30. If desired, the entire sheet 30 may be sealed in a sterile package. as is known in the art.
  • the anesthetic agent may be applied to the gauze pad, and the assembly packaged, or the anesthetic agent may be packaged separately and applied to the gauze immediately before use.
  • the multiple patch 30 may be applied to the skin for intradermal allergen testing (FIG. 7).
  • the base layer 35 carries the occlusive member and gauze and holds the patch 30 on the skin.
  • the multiple patch 35 may be removed (FIG. 8) to reveal the blue skin marking material on the edges of each pad, which is transferred to the skin and forms a series of blue frame-like marks indicating the spots where the anesthetic agent has been applied to the intact skin. It is therefore within these marks where the doctor performs his allergen testing without causing pain to the patient.
  • a perforated base sheet 40 of skin adherent" material such as tape forms a plurality of generally square or rectangular sections, and each section includes a skin patch 10.
  • An overlying sheet of correspondingly perforated plastic material 41 is then placed over the base sheet 40 in position such that individual patches 10 may be separated one at a time by tearing along the perforations.
  • thin patches 10 on individualized rectangular pieces of tape 45 are mounted on a continuous strip or roll 46 of plastic material. In this form, individual patches 10 may be separated by severing them from the roll 46.
  • the multiple type of anesthetic patch is used primarily for allergen intradermal skin testing.
  • the gauze squares are by inch in area.
  • a strip of elastic adhesive base material 3 inches wide by 7 inches long contains two vertical rows of five of these squares 1 inch apart.
  • Each of the 10 small gauze areas is saturated with the anesthetic cream before application to the skin.
  • the multiple patch is then applied to the upper arms or upper back depending upon the age of the patient (in small children up to the age of approximately 6 years the back is used.)
  • the application of two multiple anesthetic patches thus produces four rows of five anesthetized demarcated skin testing areas each or 20 sites for allergen intradermal skin testing.
  • Solitary patches consist of larger gauze squares demarcated with blue skin marking crayon placed on the adhesive base material of appropriate size depending upon the procedure to be performed. These solitary patches are made 1 inch square to 2 inches square or larger. For a needle puncture, such as an injection, or venipuncture, one can use a small anesthetic patch for lumbar punctures, a larger one is used as a 2 inch square, for minor surgery an anesthetic patch 2 inches square or possible 3 inches or larger can be used.
  • the multiple anesthetic patch has been utilized experimentally for a period of over 9 years for the performance of painless intradermal allergy skin testing at the allergy clinic and in private practice. Objectively and subjectivelyit has been observed that the anesthetic patch produces local anesthesia and permits painless skin testing. Women especially are pleased at the absense of pain during skin testing. Some remarked that they had been very anxious about the testing but were happy to find that they were painless. In children the most gratifying results have been observed. Generally speaking the elimination of the pain aspect of skin testing has had a uniformly noticeable effect on the ease of execution of the tests. The most obvious beneficial effect has been the lessened apprehension and anxiety in all concerned.
  • the application of the anesthetic patch produces neatly visible demarcated areas, anesthetized skin for each test allergen. This permits a slow accurate execution of the allergy tests in contrast to the hurried painful application; this latter situation usually producing an atmosphere of tense emotion and confusion in a struggling, crying. frightened child.
  • the psychological suggestive aspect of the pre-injection care of the skin area to be injected by a soothing painless procedure like the anesthetic patch lessens the apprehension of the child. Together these factors thus promote accuracy in skin testing and in many ways alieviate the difficulties in the allergen testing of children.
  • the anesthetic patch adds a scientific aura and dignity to the procedure of allergy skin testing. Incidentally, allergy testing is made easier for inexperienced individuals such as paramedical personnel or others who are not too adept at the procedure. The allergy tests can be done without the necessity of performing them rapidly on a struggling uncomfortable patient.
  • the anesthetic patch has been used experimentally to provide complete anesthesia for various procedures such as phlebotomies, spinal taps, and injections. Many of these cases require repeated intravenous injections and spinal taps.
  • Lidocaine is an amino-acyl amide, completely unrelated to the other (caine) drugs such as Nupercaine, Procaine, etc. It is virtually nonallergenic.
  • the anesthetic patch would seem to have properties of an ideal anesthetic agent. which are considered to be: (1) effectiveness on topical application to the skin; (2) potency for abolition of pain sensation; (3) adequate duration of anesthesia; (4) inability to cause allergenic sensitization; (5) inability to diminish the den'nal response of allergenic skin testing.
  • the anesthetic patch does not alter the skin reactions to allergen testing. Controlled studies showed no appreciable difference in skin test reactions such as 4+, 3+, or otherwise, between anesthetic patch areas and adjacent control areas; (6) freedom from skin irritation; and (7) freedom from side effects.
  • the duration of the anesthetic effect produced by an anesthetic patch varies with the time of application. If the time of application is 4 hours, the anesthetic effect exists for approximately 3 hours; for 3 hours application time the effect lasts for over an hour and a half; and for 2 hours application time over one-half hour. The anesthesia is profound and very complete.
  • the anesthetic patch of appropriate type can be applied by the patient at home before going to the clinic, hospital, or office, so that by the time the patient is to be subjected to a painful procedure an anesthetized area has been prepared. This fact may well permit many procedures, especially in children, to be performed in the physicians office rather than requiring hospitalization and other anesthesia.
  • the patient is supplied with a package which contains an alcohol wipe, a small disposal syringe with adequate anesthetic cream, an anesthetic patch and a printed form of instructions for self-application of the patient. In effect, the patient is his own anesthetist.
  • the anesthetic patch clearly has many advantages over other methods of anesthesia for local painful procedures: (I) no initial pain from needles for local anesthetic or other methods such as freezing sprays: (2) the anesthesia is localized to the exact area require for the procedure; (3) there is no swelling or distortion of the area by infiltration from the localanesthetic solution or other anesthetic agent sprayed on; (4) no adverse side effects can occur from systemic adsorption of a local anesthetic agent.
  • a very prominent advantage is the lessening of the anxiety and fear of the patient during the performance of the painful procedure.
  • a number of cases of marked needle phobia where a stick of the needle would cause syncope on the first effort were found to be ameliorated by the anesthetic patch usage, so that after several visits with the usage of the anesthetic patch the needle phobia remarkably improved.
  • the anesthetic patch may be used for immunization and other injections (diabetics), skin biopsies, minor surgical procedures such as removal of cysts, moles, skin lesions, lumbar punctures, venipunctures, etc.
  • An anesthetic patch for topical application to a predetermined area of intact skin of a patient to produce local anesthesia within such area comprising:
  • absorbent pad means of surface dimensions larger than said area but smaller than said backing member positioned on said backing member with an exposed portion of said backing member surrounding said pad means
  • occlusive means for securing said pad means in occlusively sealed pressure contact with said area of the patients skin to increase percutaneous penetration of said anesthetic agent into the opposed intact and intradermal skin and adjacent tissue for producing anesthesia thereof, and
  • said occlusive means being constituted in part by the fact that the portion of said backing member overlying and surrounding said pad means is substantially impermeable, in part by the fact that said pad means is of substantial thicknesses, and in part by the provision of an adhesive coating on said surrounding portion of said backing member establishing a continuous ring of scaled engagement between said backing member and the patients skin.
  • anesthetic patch as defined in claim 1 wherein said occlusive means is also constituted in part by a pressure member secured on said surrounding portion of said backing member outwardly of said pad means and of comparable thickness to but more dense material than said pad means to maintain pressure on skin of the patient adjacent said predetermined area while said pad means with said anesthetic agent therein is maintained in firm contact with said skin area.
  • anesthetic patch as defined in claim 1 wherein said anesthetic agent is a mixture of anesthetic material in a carrier, and wherein said anesthetic material is a nonallergenic anesthetic of the amino-acyl amide type.
  • anesthetic patch as defined in claim 1 wherein said anesthetic agent is a mixture comprising a nonallergenic anesthetic of the amino-acyl amide type and a carrier comprising dimethylsulfoxide.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US00237712A 1972-03-24 1972-03-24 Occlusively applied anesthetic patch Expired - Lifetime US3814095A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US00237712A US3814095A (en) 1972-03-24 1972-03-24 Occlusively applied anesthetic patch
CA166,704A CA1015660A (en) 1972-03-24 1973-03-21 Occlusively applied anesthetic patch
DE19732314509 DE2314509A1 (de) 1972-03-24 1973-03-23 Verschliessend aufgebrachtes anaesthesiepflaster
GB1415073A GB1408079A (en) 1972-03-24 1973-03-23 Anesthetic patch device
JP48034020A JPS498091A (US06299757-20011009-C00006.png) 1972-03-24 1973-03-24

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Application Number Priority Date Filing Date Title
US00237712A US3814095A (en) 1972-03-24 1972-03-24 Occlusively applied anesthetic patch

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US3814095A true US3814095A (en) 1974-06-04

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US00237712A Expired - Lifetime US3814095A (en) 1972-03-24 1972-03-24 Occlusively applied anesthetic patch

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US (1) US3814095A (US06299757-20011009-C00006.png)
JP (1) JPS498091A (US06299757-20011009-C00006.png)
CA (1) CA1015660A (US06299757-20011009-C00006.png)
DE (1) DE2314509A1 (US06299757-20011009-C00006.png)
GB (1) GB1408079A (US06299757-20011009-C00006.png)

Cited By (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896789A (en) * 1974-06-10 1975-07-29 Riker Laboratories Inc Retinoic acid dipensing pressure sensitive dermotological tape
US4377159A (en) * 1981-06-29 1983-03-22 Minnesota Mining And Manufacturing Company Pressure bandages and methods for making the same
WO1986002262A1 (en) * 1984-10-15 1986-04-24 Edward Teeple Surgical eye mask
US4588400A (en) * 1982-12-16 1986-05-13 Johnson & Johnson Products, Inc. Liquid loaded pad for medical applications
US4687476A (en) * 1983-07-14 1987-08-18 Eric Pailin Topical dressings
US4710191A (en) * 1985-12-16 1987-12-01 Jonergin, Inc. Therapeutic device for the administration of medicaments
US4822617A (en) * 1983-01-18 1989-04-18 Elan Corporation P.L.C. Drug delivery device
US4858604A (en) * 1981-12-09 1989-08-22 Nippon Zoki Pharmaceutical Co., Ltd. Adhesive bandage
EP0331392A2 (en) * 1988-03-01 1989-09-06 Alza Corporation Anesthesia and antisepsis of the skin
US4878775A (en) * 1987-10-28 1989-11-07 Minnesota Mining And Manufacturing Company Liquid transfer device
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US5060662A (en) * 1990-07-06 1991-10-29 Farnswoth Iii Kenneth F Open air bandage
US5116357A (en) * 1990-10-11 1992-05-26 Eberbach Mark A Hernia plug and introducer apparatus
US5180360A (en) * 1991-04-15 1993-01-19 Rhame Jr Robert W Atraumatic eye patch
US5181914A (en) * 1988-08-22 1993-01-26 Zook Gerald P Medicating device for nails and adjacent tissue
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5366460A (en) * 1990-10-11 1994-11-22 Cook Incorporated Apparatus and method for laparoscope hernia repair
US5389066A (en) * 1991-04-15 1995-02-14 Rhame, Jr.; Robert W. Atraumatic eye patch
US5415866A (en) * 1993-07-12 1995-05-16 Zook; Gerald P. Topical drug delivery system
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5505958A (en) * 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5540669A (en) * 1993-09-30 1996-07-30 Becton, Dickinson And Company Iontophoretic drug delivery system and method for using same
US5622993A (en) * 1994-11-14 1997-04-22 Medical Polymers Stick formulations for topical drug delivery of therapeutic agents and uses thereof
US5682726A (en) * 1994-09-30 1997-11-04 Becton Dickinson And Company Method for forming and packaging iontophoretic drug delivery patches and the like to increase stability and shelf-life
WO1998013099A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company User activated iontophoretic device and method for activating same
WO1998013100A1 (en) 1996-09-27 1998-04-02 Becton, Dickinson And Company Iontophoretic drug delivery system, including unit for dispensing patches
WO1998013098A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for activating same
WO1998013096A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system including method for activating same for attachment to patient
WO1998013097A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for determining hydration of patch
US5762494A (en) * 1997-03-24 1998-06-09 Archambault; Gregory A. Applicator device and method
US5817044A (en) * 1992-11-05 1998-10-06 Becton Dickenson And Company User activated iontophoertic device
US5817145A (en) * 1994-11-21 1998-10-06 Augustine Medical, Inc. Wound treatment device
EP0893139A2 (en) 1997-07-25 1999-01-27 Becton, Dickinson and Company An iontophoretic drug delivery system
US5947914A (en) * 1995-02-21 1999-09-07 Augustine Medical, Inc. Wound covering
US5954684A (en) * 1993-09-30 1999-09-21 Becton Dickinson And Company Iontophoretic drug delivery system and method for using same
US5954680A (en) * 1992-06-19 1999-09-21 Augustine Medical, Inc. Near hyperthermic heater wound covering
US5964723A (en) * 1992-06-19 1999-10-12 Augustine Medical, Inc. Normothermic tissue heating wound covering
US5986163A (en) * 1992-06-19 1999-11-16 Augustine Medical, Inc. Normothermic heater wound covering
US6093160A (en) * 1994-11-21 2000-07-25 Augustine Medical, Inc. Flexible non-contact wound treatment device
US6110197A (en) * 1994-11-21 2000-08-29 Augustine Medical, Inc. Flexible non-contact wound treatment device with a single joint
WO2000074772A1 (en) 1999-06-09 2000-12-14 Becton, Dickinson And Company Iontophoretic drug delivery device and reservoir and method of making same
WO2001030287A1 (en) * 1999-10-25 2001-05-03 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6269820B1 (en) 1998-02-26 2001-08-07 Xomed Surgical Products, Inc. Method of controlling post-operative leakage associated with tumescent liposuction
US20020065494A1 (en) * 2000-11-29 2002-05-30 Lockwood Jeffrey S. Vacuum therapy and cleansing dressing for wounds
US6406448B1 (en) 1992-06-19 2002-06-18 Augustine Medical, Inc. Normothermic heater covering for tissue treatment
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US6465708B1 (en) 1992-06-19 2002-10-15 Augustine Medical, Inc. Covering
US6469227B1 (en) 1999-12-10 2002-10-22 Lectec Corporation Antipruritic patch
US20020161346A1 (en) * 2000-11-29 2002-10-31 Lockwood Jeffrey S. Vacuum therapy and cleansing dressing for wounds
US20020183702A1 (en) * 1999-11-29 2002-12-05 Henley Alan Wayne Wound treatment apparatus
US20030014022A1 (en) * 2001-07-12 2003-01-16 Lockwood Jeffrey S. Control of vacuum level rate of change
US20030107149A1 (en) * 2001-10-12 2003-06-12 International Fluidics. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20040039391A1 (en) * 2002-08-23 2004-02-26 Argenta Louis C. Bone treatment employing reduced pressure
US20040122434A1 (en) * 2002-08-23 2004-06-24 Argenta Louis C. Bone treatment employing reduced pressure
US20040249353A1 (en) * 1999-11-29 2004-12-09 Risks James R. Wound treatment apparatus
US20050037055A1 (en) * 2002-04-11 2005-02-17 Monosolrx Llc. Polyethylene oxide-based films and drug delivery systems made therefrom
US20050085795A1 (en) * 2002-02-28 2005-04-21 Lockwood Jeffrey S. External catheter access to vacuum bandage
US20050131338A1 (en) * 1993-09-30 2005-06-16 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
EP1586347A1 (en) 2004-04-07 2005-10-19 Vyteris, Inc. Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
WO2005099811A2 (en) 2004-04-07 2005-10-27 Vyteris, Inc. Physical structural mechanical electrical and electromechanical features for use in association with electrically assisted delivery devices and systems
US20060039958A1 (en) * 2003-05-28 2006-02-23 Monosolrx, Llc. Multi-layer films having uniform content
US7063859B1 (en) 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
US20060147493A1 (en) * 2002-07-22 2006-07-06 Yang Robert K Packaging and dispensing of rapid dissolve dosage form
US20060213527A1 (en) * 1991-11-14 2006-09-28 Argenta Louis C Wound treatment employing reduced pressure
US20070026028A1 (en) * 2005-07-26 2007-02-01 Close Kenneth B Appliance for delivering a composition
US7183454B1 (en) * 1997-05-26 2007-02-27 L.R. R&D, Ltd. Multipurpose dynamic occlusive dressing
US7195624B2 (en) 2001-12-26 2007-03-27 Hill-Rom Services, Inc. Vented vacuum bandage with irrigation for wound healing and method
US20070071801A1 (en) * 2005-09-26 2007-03-29 Kelly Jack P Patch for treating symptoms of a skin abscess
US20070078373A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch
US20070078372A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia
US20070078434A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices
WO2007041158A1 (en) 2005-09-30 2007-04-12 Vyteris, Inc. Iontophoresis drug delivery device providing acceptable depth and duration of dermal anesthesia
US20070122455A1 (en) * 2001-10-12 2007-05-31 Monosolrx, Llc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20070149731A1 (en) * 2001-10-12 2007-06-28 Monosolrx, Llc. PH modulated films for delivery of actives
US20070154527A1 (en) * 2001-10-12 2007-07-05 Monosoirx, Llc Topical film compositions for delivery of actives
US20070172515A1 (en) * 2006-01-20 2007-07-26 Monosolrx, Llc Film bandage for mucosal administration of actives
US20070190157A1 (en) * 2006-01-20 2007-08-16 Monosoirx, Llc. Film lined packaging and method of making same
US7276051B1 (en) 1998-08-07 2007-10-02 Hill-Rom Services, Inc. Wound treatment apparatus
USRE39896E1 (en) 2000-09-15 2007-10-23 Gpt Glendale, Inc. Disposable eye patch and method of manufacturing a disposable eye patch
US20070281003A1 (en) * 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20080044454A1 (en) * 2002-04-11 2008-02-21 Monosolrx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20080075825A1 (en) * 2006-09-20 2008-03-27 Fuisz Richard C Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent
US20080081071A1 (en) * 2006-09-29 2008-04-03 Pradeep Sanghvi Film Embedded Packaging and Method of Making Same
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20080102093A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080103461A1 (en) * 2006-10-31 2008-05-01 Johnson Kroy D Appliance for delivering a composition, the appliance having an outer fibrous layer and inner liquid-impermeable layer
US20080103460A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Method for making an appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080116096A1 (en) * 2006-11-17 2008-05-22 Johnson Kroy D Liquid-permeable appliance for delivering a composition
US20080154254A1 (en) * 2006-12-21 2008-06-26 Myoscience, Inc. Dermal and Transdermal Cryogenic Microprobe Systems and Methods
US20080208147A1 (en) * 2007-01-10 2008-08-28 Argenta Louis C Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US20080208171A1 (en) * 2007-02-23 2008-08-28 Argenta Louis C Device and method for removing edema
US20080260809A1 (en) * 2002-04-11 2008-10-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20080281324A1 (en) * 2006-11-17 2008-11-13 Webb Lawrence X External fixation assembly and method of use
US7534927B2 (en) 2001-12-26 2009-05-19 Hill-Rom Services, Inc. Vacuum bandage packing
US7584754B1 (en) 2001-11-19 2009-09-08 Sperian Eye & Face Protection, Inc. Disposable eye patch and method of manufacturing a disposable eye patch
US20100021526A1 (en) * 2001-10-12 2010-01-28 Monosol Rx, Llc Ph modulated films for delivery of actives
US7678090B2 (en) 1999-11-29 2010-03-16 Risk Jr James R Wound treatment apparatus
US7723560B2 (en) 2001-12-26 2010-05-25 Lockwood Jeffrey S Wound vacuum therapy dressing kit
US20110033541A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20110033542A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7896856B2 (en) 2002-08-21 2011-03-01 Robert Petrosenko Wound packing for preventing wound closure
US7910791B2 (en) 2000-05-22 2011-03-22 Coffey Arthur C Combination SIS and vacuum bandage and method
CN101366675B (zh) * 2008-09-12 2011-03-23 广州伟韬电子科技有限公司 一种创可贴
US7927318B2 (en) 2001-10-11 2011-04-19 Risk Jr James Robert Waste container for negative pressure therapy
US20110144631A1 (en) * 2005-05-20 2011-06-16 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US8168848B2 (en) 2002-04-10 2012-05-01 KCI Medical Resources, Inc. Access openings in vacuum bandage
WO2012082798A3 (en) * 2010-12-13 2012-08-02 Palmer Iii Francis R Method for reducing hyperdynamic facial wrinkles
US8267960B2 (en) 2008-01-09 2012-09-18 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20140170593A1 (en) * 2012-12-18 2014-06-19 Oltuse, Llc Patch for non-invasive pain relief
US8834520B2 (en) 2007-10-10 2014-09-16 Wake Forest University Devices and methods for treating spinal cord tissue
WO2014145484A2 (en) * 2013-03-15 2014-09-18 Prometheon Pharma, Llc Devices, systems, and methods for transdermal delivery of compounds
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20150040921A1 (en) * 2013-08-11 2015-02-12 Lori R. Craig Port Cover
US8974826B2 (en) 2010-06-10 2015-03-10 Monosol Rx, Llc Nanoparticle film delivery systems
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US9101346B2 (en) 2007-11-14 2015-08-11 Myoscience, Inc. Pain management using cryogenic remodeling
US9113855B2 (en) 2007-02-16 2015-08-25 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9289193B2 (en) 2008-07-18 2016-03-22 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9345526B2 (en) 2005-05-20 2016-05-24 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US20170312406A1 (en) * 2014-11-20 2017-11-02 Mölnlycke Health Care Ab Wound Dressings
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US10368810B2 (en) 2015-07-14 2019-08-06 Welch Allyn, Inc. Method and apparatus for monitoring a functional capacity of an individual
CN110124175A (zh) * 2019-06-04 2019-08-16 武汉圣润生物科技有限公司 一种局部手术用麻醉贴
US10583228B2 (en) 2015-07-28 2020-03-10 J&M Shuler Medical, Inc. Sub-atmospheric wound therapy systems and methods
US10617350B2 (en) 2015-09-14 2020-04-14 Welch Allyn, Inc. Method and apparatus for managing a biological condition
US20200129257A1 (en) * 2019-12-31 2020-04-30 Henny Avitan Glove with Medicinal Pads and Differing Thickness Regions
US10791994B2 (en) 2016-08-04 2020-10-06 Welch Allyn, Inc. Method and apparatus for mitigating behavior adverse to a biological condition
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US10918340B2 (en) 2015-10-22 2021-02-16 Welch Allyn, Inc. Method and apparatus for detecting a biological condition
US10964421B2 (en) 2015-10-22 2021-03-30 Welch Allyn, Inc. Method and apparatus for delivering a substance to an individual
US10973416B2 (en) 2016-08-02 2021-04-13 Welch Allyn, Inc. Method and apparatus for monitoring biological conditions
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US11116397B2 (en) 2015-07-14 2021-09-14 Welch Allyn, Inc. Method and apparatus for managing sensors
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11160917B2 (en) 2020-01-22 2021-11-02 J&M Shuler Medical Inc. Negative pressure wound therapy barrier
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
CN117462836A (zh) * 2023-12-26 2024-01-30 山东百多安医疗器械股份有限公司 一种功能化超声控释穿刺敷料贴及其制备方法
US12023309B2 (en) 2022-06-08 2024-07-02 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5337624Y2 (US06299757-20011009-C00006.png) * 1974-12-03 1978-09-12
US5468501A (en) * 1982-09-01 1995-11-21 Hercon Laboratories Corporation Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant
US5310559A (en) * 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
DE3586707T2 (de) * 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
JPH0140503Y2 (US06299757-20011009-C00006.png) * 1986-08-13 1989-12-04
KR970008118B1 (ko) * 1987-07-09 1997-05-21 엘테에스 로오만 테라피-지스테메 게엠베하 운트 콤파니 카게 피부 침투성 치료 시스템
DE3810658A1 (de) * 1988-03-29 1989-10-12 Lohmann Gmbh & Co Kg Pflaster, insbesondere epikutantestpflaster und verfahren zur herstellung desselben
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator
CA2090598A1 (en) * 1992-03-04 1993-09-05 Kirti Himatlal Valia Titratable transdermal patch system and method for administration of therapeutic substances
GB2325521B (en) * 1997-05-22 1999-08-04 Geoffrey Rowe Hair care kit
US20060067994A1 (en) * 2004-09-30 2006-03-30 Kimberly-Clark Worldwide, Inc. System for providing therapy to a body

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1643926A (en) * 1927-01-05 1927-09-27 Johnson & Johnson Emergency dressing
US1861530A (en) * 1930-12-31 1932-06-07 Johnson & Johnson Mounting plasters and other adhesive faced articles
US1920808A (en) * 1929-05-10 1933-08-01 Sander Eugen Surgical bandaging
US2029260A (en) * 1933-10-28 1936-01-28 Kendall & Co Method of making adhesive tape and gauze dressings
US2344021A (en) * 1942-09-05 1944-03-14 Bouziane George Surgical bandage
US2579403A (en) * 1950-06-01 1951-12-18 Slomowitz Julius Medical bandage
US3062210A (en) * 1958-08-21 1962-11-06 William M Scholl Medicated pad or bandage and method of making the same
US3212495A (en) * 1962-06-22 1965-10-19 Hazleton Lab Inc Sensitivity test patches
US3624224A (en) * 1969-12-22 1971-11-30 Schering Corp Novel first aid products

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE519353C (de) * 1931-09-16 Eugen Sander Wundverband
GB837226A (en) * 1957-03-16 1960-06-09 Taylor Furst & Company Ltd Improvements in or relating to adhesive plaster for medical or for surgical use
JPS4424240Y1 (US06299757-20011009-C00006.png) * 1964-12-10 1969-10-13
GB1254109A (en) * 1968-05-08 1971-11-17 Trico Folberth Ltd Windscreen wiper blade assemblies
DE1767657A1 (de) * 1968-05-31 1971-11-25 Gerhard Weinz Blaettchen zum Auflegen
JPS505892Y2 (US06299757-20011009-C00006.png) * 1971-02-19 1975-02-19

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1643926A (en) * 1927-01-05 1927-09-27 Johnson & Johnson Emergency dressing
US1920808A (en) * 1929-05-10 1933-08-01 Sander Eugen Surgical bandaging
US1861530A (en) * 1930-12-31 1932-06-07 Johnson & Johnson Mounting plasters and other adhesive faced articles
US2029260A (en) * 1933-10-28 1936-01-28 Kendall & Co Method of making adhesive tape and gauze dressings
US2344021A (en) * 1942-09-05 1944-03-14 Bouziane George Surgical bandage
US2579403A (en) * 1950-06-01 1951-12-18 Slomowitz Julius Medical bandage
US3062210A (en) * 1958-08-21 1962-11-06 William M Scholl Medicated pad or bandage and method of making the same
US3212495A (en) * 1962-06-22 1965-10-19 Hazleton Lab Inc Sensitivity test patches
US3624224A (en) * 1969-12-22 1971-11-30 Schering Corp Novel first aid products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Annals Of Allergy, Vol. 22, Pages 37 41 *

Cited By (288)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896789A (en) * 1974-06-10 1975-07-29 Riker Laboratories Inc Retinoic acid dipensing pressure sensitive dermotological tape
US4377159A (en) * 1981-06-29 1983-03-22 Minnesota Mining And Manufacturing Company Pressure bandages and methods for making the same
US4858604A (en) * 1981-12-09 1989-08-22 Nippon Zoki Pharmaceutical Co., Ltd. Adhesive bandage
US4588400A (en) * 1982-12-16 1986-05-13 Johnson & Johnson Products, Inc. Liquid loaded pad for medical applications
US4822617A (en) * 1983-01-18 1989-04-18 Elan Corporation P.L.C. Drug delivery device
US4687476A (en) * 1983-07-14 1987-08-18 Eric Pailin Topical dressings
WO1986002262A1 (en) * 1984-10-15 1986-04-24 Edward Teeple Surgical eye mask
US4635625A (en) * 1984-10-15 1987-01-13 Edward Teeple Surgical eye mask
US4710191A (en) * 1985-12-16 1987-12-01 Jonergin, Inc. Therapeutic device for the administration of medicaments
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US4878775A (en) * 1987-10-28 1989-11-07 Minnesota Mining And Manufacturing Company Liquid transfer device
EP0331392A3 (en) * 1988-03-01 1990-02-14 Alza Corporation Anesthesia and antisepsis of the skin
EP0331392A2 (en) * 1988-03-01 1989-09-06 Alza Corporation Anesthesia and antisepsis of the skin
US5181914A (en) * 1988-08-22 1993-01-26 Zook Gerald P Medicating device for nails and adjacent tissue
US5060662A (en) * 1990-07-06 1991-10-29 Farnswoth Iii Kenneth F Open air bandage
US5116357A (en) * 1990-10-11 1992-05-26 Eberbach Mark A Hernia plug and introducer apparatus
US5366460A (en) * 1990-10-11 1994-11-22 Cook Incorporated Apparatus and method for laparoscope hernia repair
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5180360A (en) * 1991-04-15 1993-01-19 Rhame Jr Robert W Atraumatic eye patch
US5389066A (en) * 1991-04-15 1995-02-14 Rhame, Jr.; Robert W. Atraumatic eye patch
US20060213527A1 (en) * 1991-11-14 2006-09-28 Argenta Louis C Wound treatment employing reduced pressure
US6419651B1 (en) 1992-06-19 2002-07-16 Augustine Medical, Inc. Normothermic heater covering
US20030167029A1 (en) * 1992-06-19 2003-09-04 Augustine Scott D. Tissue treatment by normothermic heating
US6406448B1 (en) 1992-06-19 2002-06-18 Augustine Medical, Inc. Normothermic heater covering for tissue treatment
US6213966B1 (en) 1992-06-19 2001-04-10 Augustine Medical, Inc. Normothermic tissue heating wound covering
US6217535B1 (en) 1992-06-19 2001-04-17 Augustine Medical, Inc. Normothermic heater wound covering
US6921374B2 (en) 1992-06-19 2005-07-26 Arizant Healthcare Inc. Tissue treatment by normothermic heating
US6241698B1 (en) 1992-06-19 2001-06-05 Augustine Medical, Inc. Near hyperthermic heater wound covering
US6241697B1 (en) 1992-06-19 2001-06-05 Augustine Medical, Inc. Wound covering
US6071254A (en) * 1992-06-19 2000-06-06 Augustine Medical, Inc. Near hyperthermic heater wound covering
US6045518A (en) * 1992-06-19 2000-04-04 Augustine Medical, Inc. Normothermic heater wound covering
US6840915B2 (en) 1992-06-19 2005-01-11 Arizant Healthcare Inc. Normothermic tissue treatment
US5986163A (en) * 1992-06-19 1999-11-16 Augustine Medical, Inc. Normothermic heater wound covering
US6605051B2 (en) 1992-06-19 2003-08-12 Augustine Medical, Inc. Near hyperthermic tissue treatment
US5964723A (en) * 1992-06-19 1999-10-12 Augustine Medical, Inc. Normothermic tissue heating wound covering
US6465708B1 (en) 1992-06-19 2002-10-15 Augustine Medical, Inc. Covering
US6423018B1 (en) 1992-06-19 2002-07-23 Augustine Medical, Inc. Normothermic tissue heating wound covering
US6113561A (en) * 1992-06-19 2000-09-05 Augustine Medical, Inc. Normothermic tissue heating wound covering
US6264622B1 (en) 1992-06-19 2001-07-24 Augustine Medical, Inc. Normothermic heater wound covering
US5954680A (en) * 1992-06-19 1999-09-21 Augustine Medical, Inc. Near hyperthermic heater wound covering
US5817044A (en) * 1992-11-05 1998-10-06 Becton Dickenson And Company User activated iontophoertic device
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US6407307B1 (en) 1993-06-18 2002-06-18 Augustine Medical, Inc. Near hyperthermic heater covering
US5415866A (en) * 1993-07-12 1995-05-16 Zook; Gerald P. Topical drug delivery system
US5954684A (en) * 1993-09-30 1999-09-21 Becton Dickinson And Company Iontophoretic drug delivery system and method for using same
US20050131338A1 (en) * 1993-09-30 2005-06-16 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US20050159698A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US20050159700A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US20050159699A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US7043297B2 (en) 1993-09-30 2006-05-09 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5540669A (en) * 1993-09-30 1996-07-30 Becton, Dickinson And Company Iontophoretic drug delivery system and method for using same
US6096333A (en) * 1994-03-30 2000-08-01 Lectec Corporation Method of forming adhesive patch for applying medication to the skin
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US6096334A (en) * 1994-03-30 2000-08-01 Lectec Corporation Adhesive patch for applying medication to the skin and method
US5741510A (en) * 1994-03-30 1998-04-21 Lectec Corporation Adhesive patch for applying analgesic medication to the skin
US5682726A (en) * 1994-09-30 1997-11-04 Becton Dickinson And Company Method for forming and packaging iontophoretic drug delivery patches and the like to increase stability and shelf-life
US5505958A (en) * 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture
US5622993A (en) * 1994-11-14 1997-04-22 Medical Polymers Stick formulations for topical drug delivery of therapeutic agents and uses thereof
US6293917B1 (en) 1994-11-21 2001-09-25 Augustine Medical, Inc. Wound treatment device for attachment to skin
US6010527A (en) * 1994-11-21 2000-01-04 Augustine Medical, Inc. Wound treatment device
US6267740B1 (en) 1994-11-21 2001-07-31 Augustine Medical, Inc. Flexible non-contact wound treatment device with a single joint
US7122046B2 (en) 1994-11-21 2006-10-17 Arizant Technologies Llc Treatment device
US20030023286A1 (en) * 1994-11-21 2003-01-30 Augustine Scott D. Treatment device
US6248084B1 (en) 1994-11-21 2001-06-19 Augustine Medical, Inc. Wound treatment device
US6093160A (en) * 1994-11-21 2000-07-25 Augustine Medical, Inc. Flexible non-contact wound treatment device
US6013097A (en) * 1994-11-21 2000-01-11 Augautine Medical, Inc. Wound treatment device for attachment to skin
US6580012B1 (en) 1994-11-21 2003-06-17 Augustine Medical, Inc. Flexible non-contact wound treatment device
US20030069529A1 (en) * 1994-11-21 2003-04-10 Augustine Scott D. Flexible non-contact wound treatment device
US6987209B2 (en) 1994-11-21 2006-01-17 Arizant Healthcare Inc. Flexible non-contact wound treatment device
US6110197A (en) * 1994-11-21 2000-08-29 Augustine Medical, Inc. Flexible non-contact wound treatment device with a single joint
US5817145A (en) * 1994-11-21 1998-10-06 Augustine Medical, Inc. Wound treatment device
US6468295B2 (en) 1994-11-21 2002-10-22 Augustine Medical, Inc. Treatment device
US5964721A (en) * 1995-02-21 1999-10-12 Augustine Medical, Inc. Wound covering
US5947914A (en) * 1995-02-21 1999-09-07 Augustine Medical, Inc. Wound covering
WO1998013100A1 (en) 1996-09-27 1998-04-02 Becton, Dickinson And Company Iontophoretic drug delivery system, including unit for dispensing patches
WO1998013098A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for activating same
WO1998013096A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system including method for activating same for attachment to patient
WO1998013099A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company User activated iontophoretic device and method for activating same
WO1998013097A1 (en) 1996-09-27 1998-04-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for determining hydration of patch
US5762494A (en) * 1997-03-24 1998-06-09 Archambault; Gregory A. Applicator device and method
US7183454B1 (en) * 1997-05-26 2007-02-27 L.R. R&D, Ltd. Multipurpose dynamic occlusive dressing
EP0893139A2 (en) 1997-07-25 1999-01-27 Becton, Dickinson and Company An iontophoretic drug delivery system
US6269820B1 (en) 1998-02-26 2001-08-07 Xomed Surgical Products, Inc. Method of controlling post-operative leakage associated with tumescent liposuction
US7276051B1 (en) 1998-08-07 2007-10-02 Hill-Rom Services, Inc. Wound treatment apparatus
US7794438B2 (en) 1998-08-07 2010-09-14 Alan Wayne Henley Wound treatment apparatus
US8540687B2 (en) 1998-08-07 2013-09-24 Kci Licensing, Inc. Wound treatment apparatus
US7063859B1 (en) 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
WO2000074772A1 (en) 1999-06-09 2000-12-14 Becton, Dickinson And Company Iontophoretic drug delivery device and reservoir and method of making same
WO2001030287A1 (en) * 1999-10-25 2001-05-03 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US20040058994A1 (en) * 1999-10-25 2004-03-25 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6645521B2 (en) * 1999-10-25 2003-11-11 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
AU779570B2 (en) * 1999-10-25 2005-01-27 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US7678090B2 (en) 1999-11-29 2010-03-16 Risk Jr James R Wound treatment apparatus
US7763000B2 (en) 1999-11-29 2010-07-27 Risk Jr James R Wound treatment apparatus having a display
US20040249353A1 (en) * 1999-11-29 2004-12-09 Risks James R. Wound treatment apparatus
US20020183702A1 (en) * 1999-11-29 2002-12-05 Henley Alan Wayne Wound treatment apparatus
US6800074B2 (en) 1999-11-29 2004-10-05 Hill-Rom Services, Inc. Wound treatment apparatus
US8021348B2 (en) 1999-11-29 2011-09-20 Kci Medical Resources Wound treatment apparatus
US6469227B1 (en) 1999-12-10 2002-10-22 Lectec Corporation Antipruritic patch
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US6746689B2 (en) 2000-03-10 2004-06-08 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US8747887B2 (en) 2000-05-22 2014-06-10 Kci Medical Resources Combination SIS and vacuum bandage and method
US7910791B2 (en) 2000-05-22 2011-03-22 Coffey Arthur C Combination SIS and vacuum bandage and method
USRE39896E1 (en) 2000-09-15 2007-10-23 Gpt Glendale, Inc. Disposable eye patch and method of manufacturing a disposable eye patch
US20020161346A1 (en) * 2000-11-29 2002-10-31 Lockwood Jeffrey S. Vacuum therapy and cleansing dressing for wounds
US20020065494A1 (en) * 2000-11-29 2002-05-30 Lockwood Jeffrey S. Vacuum therapy and cleansing dressing for wounds
US7867206B2 (en) 2000-11-29 2011-01-11 Kci Licensing, Inc. Vacuum therapy and cleansing dressing for wounds
US10357404B2 (en) 2000-11-29 2019-07-23 Kci Medical Resources Unlimited Company Vacuum therapy and cleansing dressing for wounds
US7988680B2 (en) 2000-11-29 2011-08-02 Kci Medical Resources Vacuum therapy and cleansing dressing for wounds
US6855135B2 (en) 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6752794B2 (en) 2000-11-29 2004-06-22 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US8246592B2 (en) 2000-11-29 2012-08-21 Kci Medical Resources Vacuum therapy and cleansing dressing for wounds
US6685681B2 (en) 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US7022113B2 (en) 2001-07-12 2006-04-04 Hill-Rom Services, Inc. Control of vacuum level rate of change
US20030014022A1 (en) * 2001-07-12 2003-01-16 Lockwood Jeffrey S. Control of vacuum level rate of change
US7927318B2 (en) 2001-10-11 2011-04-19 Risk Jr James Robert Waste container for negative pressure therapy
US7824588B2 (en) 2001-10-12 2010-11-02 Monosol Rx, Llc Method of making self-supporting therapeutic active-containing film
US9931305B2 (en) 2001-10-12 2018-04-03 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8685437B2 (en) 2001-10-12 2014-04-01 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070122455A1 (en) * 2001-10-12 2007-05-31 Monosolrx, Llc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20070149731A1 (en) * 2001-10-12 2007-06-28 Monosolrx, Llc. PH modulated films for delivery of actives
US20070154527A1 (en) * 2001-10-12 2007-07-05 Monosoirx, Llc Topical film compositions for delivery of actives
US8652378B1 (en) 2001-10-12 2014-02-18 Monosol Rx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20030107149A1 (en) * 2001-10-12 2003-06-12 International Fluidics. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20070069416A1 (en) * 2001-10-12 2007-03-29 Monosolrx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070281003A1 (en) * 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20100021526A1 (en) * 2001-10-12 2010-01-28 Monosol Rx, Llc Ph modulated films for delivery of actives
US9855221B2 (en) 2001-10-12 2018-01-02 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20090181069A1 (en) * 2001-10-12 2009-07-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20080260805A1 (en) * 2001-10-12 2008-10-23 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20050184427A1 (en) * 2001-10-12 2005-08-25 Monosolrx, Llc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US10888499B2 (en) 2001-10-12 2021-01-12 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7584754B1 (en) 2001-11-19 2009-09-08 Sperian Eye & Face Protection, Inc. Disposable eye patch and method of manufacturing a disposable eye patch
US7896864B2 (en) 2001-12-26 2011-03-01 Lockwood Jeffrey S Vented vacuum bandage with irrigation for wound healing and method
US7723560B2 (en) 2001-12-26 2010-05-25 Lockwood Jeffrey S Wound vacuum therapy dressing kit
US7195624B2 (en) 2001-12-26 2007-03-27 Hill-Rom Services, Inc. Vented vacuum bandage with irrigation for wound healing and method
US7534927B2 (en) 2001-12-26 2009-05-19 Hill-Rom Services, Inc. Vacuum bandage packing
US8350116B2 (en) 2001-12-26 2013-01-08 Kci Medical Resources Vacuum bandage packing
US20050085795A1 (en) * 2002-02-28 2005-04-21 Lockwood Jeffrey S. External catheter access to vacuum bandage
US7338482B2 (en) 2002-02-28 2008-03-04 Hill-Rom Services, Inc. External catheter access to vacuum bandage
US8168848B2 (en) 2002-04-10 2012-05-01 KCI Medical Resources, Inc. Access openings in vacuum bandage
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20080260809A1 (en) * 2002-04-11 2008-10-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20080044454A1 (en) * 2002-04-11 2008-02-21 Monosolrx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10111810B2 (en) 2002-04-11 2018-10-30 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20050037055A1 (en) * 2002-04-11 2005-02-17 Monosolrx Llc. Polyethylene oxide-based films and drug delivery systems made therefrom
US20060147493A1 (en) * 2002-07-22 2006-07-06 Yang Robert K Packaging and dispensing of rapid dissolve dosage form
US7896856B2 (en) 2002-08-21 2011-03-01 Robert Petrosenko Wound packing for preventing wound closure
US20040122434A1 (en) * 2002-08-23 2004-06-24 Argenta Louis C. Bone treatment employing reduced pressure
US20040039391A1 (en) * 2002-08-23 2004-02-26 Argenta Louis C. Bone treatment employing reduced pressure
US20060039958A1 (en) * 2003-05-28 2006-02-23 Monosolrx, Llc. Multi-layer films having uniform content
WO2005099811A2 (en) 2004-04-07 2005-10-27 Vyteris, Inc. Physical structural mechanical electrical and electromechanical features for use in association with electrically assisted delivery devices and systems
EP1586347A1 (en) 2004-04-07 2005-10-19 Vyteris, Inc. Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
US9072498B2 (en) 2005-05-20 2015-07-07 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20110144631A1 (en) * 2005-05-20 2011-06-16 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11963706B2 (en) 2005-05-20 2024-04-23 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11350979B2 (en) 2005-05-20 2022-06-07 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9345526B2 (en) 2005-05-20 2016-05-24 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US10363080B2 (en) 2005-05-20 2019-07-30 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070026028A1 (en) * 2005-07-26 2007-02-01 Close Kenneth B Appliance for delivering a composition
WO2007038329A2 (en) * 2005-09-26 2007-04-05 Jack Kelly A patch for treating symptoms of a skin abscess
US20070071801A1 (en) * 2005-09-26 2007-03-29 Kelly Jack P Patch for treating symptoms of a skin abscess
US7320801B2 (en) * 2005-09-26 2008-01-22 Jack Perez Kelly Patch for treating symptoms of a skin abscess
WO2007038329A3 (en) * 2005-09-26 2007-06-28 Jack Kelly A patch for treating symptoms of a skin abscess
WO2007041386A2 (en) 2005-09-30 2007-04-12 Vyteris, Inc. Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch
US20070093743A1 (en) * 2005-09-30 2007-04-26 Vyteris, Inc. Iontophoresis Drug Delivery Device Providing Acceptable Depth and Duration of Dermal Anesthesia
EP2269689A1 (en) 2005-09-30 2011-01-05 Vyteris Inc. Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch
WO2007041158A1 (en) 2005-09-30 2007-04-12 Vyteris, Inc. Iontophoresis drug delivery device providing acceptable depth and duration of dermal anesthesia
US20070078372A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia
US20070078373A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch
US20070078434A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices
US20070172515A1 (en) * 2006-01-20 2007-07-26 Monosolrx, Llc Film bandage for mucosal administration of actives
US20070190157A1 (en) * 2006-01-20 2007-08-16 Monosoirx, Llc. Film lined packaging and method of making same
US7972618B2 (en) 2006-09-20 2011-07-05 Monosol Rx, Llc Edible water-soluble film containing a foam reducing flavoring agent
US20080075825A1 (en) * 2006-09-20 2008-03-27 Fuisz Richard C Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent
US20080081071A1 (en) * 2006-09-29 2008-04-03 Pradeep Sanghvi Film Embedded Packaging and Method of Making Same
US20080102093A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080103461A1 (en) * 2006-10-31 2008-05-01 Johnson Kroy D Appliance for delivering a composition, the appliance having an outer fibrous layer and inner liquid-impermeable layer
US20080103460A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Method for making an appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US8956644B2 (en) 2006-11-03 2015-02-17 Durect Corporation Transdermal delivery systems
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
US20080116096A1 (en) * 2006-11-17 2008-05-22 Johnson Kroy D Liquid-permeable appliance for delivering a composition
US8454603B2 (en) 2006-11-17 2013-06-04 Wake Forest University Health Sciences External fixation assembly and method of use
US20080281324A1 (en) * 2006-11-17 2008-11-13 Webb Lawrence X External fixation assembly and method of use
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US9050136B2 (en) 2006-11-17 2015-06-09 Wake Forest University Health Sciences External fixation assembly and method of use
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US10939947B2 (en) 2006-12-21 2021-03-09 Pacira Cryotech, Inc. Dermal and transdermal cryogenic microprobe systems
US20080154254A1 (en) * 2006-12-21 2008-06-26 Myoscience, Inc. Dermal and Transdermal Cryogenic Microprobe Systems and Methods
US20080208147A1 (en) * 2007-01-10 2008-08-28 Argenta Louis C Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US9737455B2 (en) 2007-01-10 2017-08-22 Wake Forest Univeristy Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US9113855B2 (en) 2007-02-16 2015-08-25 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US20080208171A1 (en) * 2007-02-23 2008-08-28 Argenta Louis C Device and method for removing edema
US8834520B2 (en) 2007-10-10 2014-09-16 Wake Forest University Devices and methods for treating spinal cord tissue
US10864112B2 (en) 2007-11-14 2020-12-15 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US10869779B2 (en) 2007-11-14 2020-12-22 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US9101346B2 (en) 2007-11-14 2015-08-11 Myoscience, Inc. Pain management using cryogenic remodeling
US9907693B2 (en) 2007-11-14 2018-03-06 Myoscience, Inc. Pain management using cryogenic remodeling
US11672694B2 (en) 2007-11-14 2023-06-13 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US8764794B2 (en) 2008-01-09 2014-07-01 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US8267960B2 (en) 2008-01-09 2012-09-18 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US10076318B2 (en) 2008-07-18 2018-09-18 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US9289193B2 (en) 2008-07-18 2016-03-22 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
CN101366675B (zh) * 2008-09-12 2011-03-23 广州伟韬电子科技有限公司 一种创可贴
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US10034833B2 (en) 2009-08-07 2018-07-31 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US20110033542A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20110033541A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US11135216B2 (en) 2009-08-07 2021-10-05 Indivior Uk Limited Sublingual and buccal film compositions
US9687454B2 (en) 2009-08-07 2017-06-27 Indivior Uk Limited Sublingual and buccal film compositions
US10821074B2 (en) 2009-08-07 2020-11-03 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8974826B2 (en) 2010-06-10 2015-03-10 Monosol Rx, Llc Nanoparticle film delivery systems
US10940626B2 (en) 2010-10-22 2021-03-09 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US9039688B2 (en) * 2010-12-13 2015-05-26 Myoscience, Inc. Method for reducing hyperdynamic facial wrinkles
CN103561673A (zh) * 2010-12-13 2014-02-05 肌肉科技股份有限公司 减少肌力过度性面部皱纹的方法
US20120265187A1 (en) * 2010-12-13 2012-10-18 Myoscience, Inc. Method for Reducing Hyperdynamic Facial Wrinkles
WO2012082798A3 (en) * 2010-12-13 2012-08-02 Palmer Iii Francis R Method for reducing hyperdynamic facial wrinkles
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US10188444B2 (en) 2012-01-13 2019-01-29 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US10213244B2 (en) 2012-01-13 2019-02-26 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US11857239B2 (en) 2012-01-13 2024-01-02 Pacira Cryotech, Inc. Cryogenic needle with freeze zone regulation
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US20140170593A1 (en) * 2012-12-18 2014-06-19 Oltuse, Llc Patch for non-invasive pain relief
WO2014145484A2 (en) * 2013-03-15 2014-09-18 Prometheon Pharma, Llc Devices, systems, and methods for transdermal delivery of compounds
US11642241B2 (en) 2013-03-15 2023-05-09 Pacira Cryotech, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US11253393B2 (en) 2013-03-15 2022-02-22 Pacira Cryotech, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US11865038B2 (en) 2013-03-15 2024-01-09 Pacira Cryotech, Inc. Methods, systems, and devices for treating nerve spasticity
US10085881B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US10314739B2 (en) 2013-03-15 2019-06-11 Myoscience, Inc. Methods and devices for pain management
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US10596030B2 (en) 2013-03-15 2020-03-24 Pacira Cryotech, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
WO2014145484A3 (en) * 2013-03-15 2014-12-24 Prometheon Pharma, Llc Devices, systems, and methods for transdermal delivery of compounds
US11134999B2 (en) 2013-03-15 2021-10-05 Pacira Cryotech, Inc. Methods and systems for treatment of occipital neuralgia
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US10085789B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US20150040921A1 (en) * 2013-08-11 2015-02-12 Lori R. Craig Port Cover
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US11690661B2 (en) 2013-11-05 2023-07-04 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US10864033B2 (en) 2013-11-05 2020-12-15 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US20170312406A1 (en) * 2014-11-20 2017-11-02 Mölnlycke Health Care Ab Wound Dressings
US10772999B2 (en) * 2014-11-20 2020-09-15 Mölnlycke Health Care Ab Wound dressings
US10368810B2 (en) 2015-07-14 2019-08-06 Welch Allyn, Inc. Method and apparatus for monitoring a functional capacity of an individual
US11116397B2 (en) 2015-07-14 2021-09-14 Welch Allyn, Inc. Method and apparatus for managing sensors
US10583228B2 (en) 2015-07-28 2020-03-10 J&M Shuler Medical, Inc. Sub-atmospheric wound therapy systems and methods
US10617350B2 (en) 2015-09-14 2020-04-14 Welch Allyn, Inc. Method and apparatus for managing a biological condition
US10964421B2 (en) 2015-10-22 2021-03-30 Welch Allyn, Inc. Method and apparatus for delivering a substance to an individual
US10918340B2 (en) 2015-10-22 2021-02-16 Welch Allyn, Inc. Method and apparatus for detecting a biological condition
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US10973416B2 (en) 2016-08-02 2021-04-13 Welch Allyn, Inc. Method and apparatus for monitoring biological conditions
US10791994B2 (en) 2016-08-04 2020-10-06 Welch Allyn, Inc. Method and apparatus for mitigating behavior adverse to a biological condition
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
CN110124175B (zh) * 2019-06-04 2021-04-30 武汉圣润生物科技有限公司 一种局部手术用麻醉贴
CN110124175A (zh) * 2019-06-04 2019-08-16 武汉圣润生物科技有限公司 一种局部手术用麻醉贴
US10772695B2 (en) * 2019-12-31 2020-09-15 Henny Avitan Glove with medicinal pads and differing thickness regions
US20200129257A1 (en) * 2019-12-31 2020-04-30 Henny Avitan Glove with Medicinal Pads and Differing Thickness Regions
US11160917B2 (en) 2020-01-22 2021-11-02 J&M Shuler Medical Inc. Negative pressure wound therapy barrier
US11766514B2 (en) 2020-01-22 2023-09-26 J&M Shuler Medical Inc. Negative pressure wound therapy barrier
US12027248B2 (en) 2021-02-18 2024-07-02 Welch Allyn, Inc. Method and apparatus for delivering a substance to an individual
US12023309B2 (en) 2022-06-08 2024-07-02 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
CN117462836A (zh) * 2023-12-26 2024-01-30 山东百多安医疗器械股份有限公司 一种功能化超声控释穿刺敷料贴及其制备方法
CN117462836B (zh) * 2023-12-26 2024-04-26 山东百多安医疗器械股份有限公司 一种功能化超声控释穿刺敷料贴及其制备方法

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