US3807386A - Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation - Google Patents
Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation Download PDFInfo
- Publication number
- US3807386A US3807386A US00245945A US24594572A US3807386A US 3807386 A US3807386 A US 3807386A US 00245945 A US00245945 A US 00245945A US 24594572 A US24594572 A US 24594572A US 3807386 A US3807386 A US 3807386A
- Authority
- US
- United States
- Prior art keywords
- vaginal
- probe
- plugs
- applicator
- radioactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002285 radioactive effect Effects 0.000 title claims description 20
- 238000000034 method Methods 0.000 title claims description 10
- 239000000523 sample Substances 0.000 claims abstract description 59
- 230000008878 coupling Effects 0.000 claims abstract description 19
- 238000010168 coupling process Methods 0.000 claims abstract description 19
- 238000005859 coupling reaction Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims description 12
- 229910001385 heavy metal Inorganic materials 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 5
- 238000003780 insertion Methods 0.000 abstract description 5
- 230000037431 insertion Effects 0.000 abstract description 5
- 230000000284 resting effect Effects 0.000 abstract description 2
- 210000001215 vagina Anatomy 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000004794 expanded polystyrene Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000003562 lightweight material Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1016—Gynaecological radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Definitions
- the applicator comprises a uterine probe and two vag- 1 inal probes, a coupling member consisting of a polyhedral block having low density and transparent to X- rays, the block being provided with a central passage- 1 way' for the insertion of the uterine probe and two symmetrical oblique passageways for the insertion of the two vaginal probes, two cylindrical plugs resting on the coupling member and each having a passageway for inserting the extremity of one vaginal probe.
- the coupling member is provided with cylindrical cups corresponding in the shape to the plugs and each located at one end of a vaginal-probe passageway.
- the generator-lines of the cups are inclined to the axes of the passageways of the plugs at an angle which is slightly different from 90.
- the outer tube is attached to a flexible sheath which is joined to an apparatus known as a source projector, for example of the type descirbed in US. Pat. application Ser. No. l-l,226, filed Feb. 13, 1970, now abandoned, and pseudo-sources, that is to say nonradioactive sources, are transferred by means of this projector into said outer tube, then into the applicator and the vagina;
- a source projector for example of the type descirbed in US. Pat. application Ser. No. l-l,226, filed Feb. 13, 1970, now abandoned, and pseudo-sources, that is to say nonradioactive sources, are transferred by means of this projector into said outer tube, then into the applicator and the vagina;
- the projector unit is loaded with radioactive sources, the outer tube is again attached to the sheath, whereupon said radioactive sources are transferred into the outer tube, then into the applicator and the vagina.
- the material of which the applicator is formed does not readily withstand sterilization, especially sterilization by radiation. This makes the applicator unsuited for pre-sterilization prior to use and for spray-jet treatment after use. As a further consequence, the applicator has to be carefully cleaned and sterilized each time before use.
- the constituent material of applicators is often delicate, is subject to ageing and therefore to a further major drawback in regard to storage stability;
- the projector-unit tubes which serve to place the radioactive sources in the irradiation position are often so designed as to permit introduction only in a rectilineal position by reason of the fact that, if the outer tube containing the applicator is bent, its section becomes ovalized and thus prevents easy introduction or withdrawal of radioactive source's.
- That portion of the applicator which is intended to receive the vaginal sources (namely the portion known as a colpostat) is not provided with any shield for reducing the dose applied to sound radiationsensitive tissues such as the vesical or rectal walls.
- the assembly consisting of uterine probe and colpostat is coupled by means of a metallic spring or else may not be coupled, which gives rise to two disadvantages.
- the first disadvantage is to make it very difficult to introduce the applicator through the opening of the speculum;
- the second disadvantage arises from the fact that the assembly of vaginal and uterine sources cannot be maintained in a fixed position. As a result, even accurate positioning of the applicator does not give any guarantee of satisfactory position-maintenance throughout the period of treatment.
- the number of possible respective positions of the vaginalsources with respect to the uterine source is either too small (three, for example, with three sizes of vaginal plugs) or else may be infinite if no component is provided for adjusting and maintaining a fixed respective position.
- the dosimetry is either very difficult to calculate or else does not have any parameters of variation to permit adaptation both to the patients anatomy and to the stage of development of the cancerous lesion.
- the present invention relates to an applicator which is free from the disadvantages noted in the foregoing.
- the precise object of the invention is to provide a radioactive sourceapplicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation, said applicator being characterized in that it comprises a uterine probe and two colpostats or vaginal probes, a coupling member constituted by a polyhedral block formed of material which has low density and is transparent to X-rays, said block being provided with a central passageway which serves to insert the uterine probe and with two oblique passageways which are symmetrical with respect to said central passageway and serve to insert the two vaginal probes, and two cylindrical plugs each traversed by a passageway which serves to insert the extremity of a vaginal probe and rests on said coupling member, said member being provided with hollowed-out portions in the form of cylindrical cups corresponding in shape to said plugs and each located at one extremity of a vaginal-probe passageway, the direction of the generator-lines of said cylindrical cups being inclined to
- FIG. 1 is a sectional view showing the applicator in accordance with the invention and as positioned in the patient;
- FIG. 2 is a perspective view showing the same applicator alone.
- the applicator according to the invention is essentially composed of a uterine probe 1 and of two vagina probes (or colpostats) 2 and 3 which are maintained in rigidly fixed relation during the application by means of a coupling member 4 and are disposed at the end of socalled outer tubes 10.
- the uterine probe 1 and the vaginal probes 2 and 3 are constituted by a plastic tube (for example of polyethylene) which is sterilizable under radiation.
- the internal diameter of the probes is chosen so as to permit ready introduction of flexible sourceholders even with substantial curvatures or precurvatures of the probes.
- the external diameter of the probes 1 to 3 is chosen so as to leave a thickness of plastic material which is sufficient to endow the probes with compressive strength but is not too great in order to maintain flexibility of the material (thickness comprised between 15' and 20 percent of the external diameter).
- Each vaginal probe is sealed by an added end-cap 5 which is bondedin the hot state, thus making the interior of the probe impervious to infiltrations and secretions and also sufficiently strong to prevent any sourceholder from piercing the extremity and causing injury to the patient.
- Each vaginal probe 2 or 3 supplies a plug 6, the axis of which makes an angle of approximately 100 with the axis of the corresponding vaginal probe in order to ensure better holding in place or retention within the vaginal fornices.
- Each plug 6 comprises two removable end-caps 7 so as to permit the insertion of discs of heavy metal (such as depleted uranium, lead, tungsten and the like) which serve to shield the highly radiationsensitive vesical or rectal walls.
- the applicator can be constructed in a number of different sizes which differ in the dimensions of the plugs 6 and of the coupling member 4.
- the coupling member 4 slides along the probes and can be introduced after positioning of the uterine probe 1 and the vaginal plugs 6.
- Member 4 is provided with two sets of recesses or hollowed-out portions 8 having the shape of cylindrical cups which are intended to accommodate the vaginal plugs 6.
- the arrangement of said recesses 8 makes it possible to obtain in the case of each size of plug two respective arrangements of the vaginal probes 2 and 3, namely a convergent arrangement in one case (as shown in FIG. 2) and a divergent arrangement in the other case (as shown in FIG. 1).
- the constituent material chosen for the coupling member is intended to have low density and to be transparent to X-rays (expanded polystyrene, for example).
- a collar 9 serves to support the applicator assembly in a more effective manner.
- the applicator in accordance with the invention as constructed of plastic material, has the following advantages over applicators of the prior art:
- the diameter of the uterine probe 1 is chosen so as to prevent excessive proximity of the tissues in the irradiation position (this being the case with diameters which are too small) and excessive prior expansion of the uterine duct under anaesthesia (5 to 6 mm).
- Each of the two vaginal plugs 6 of the colpostats is hollow in such manner as to permit X-ray detection and is additionally provided with two end-caps 7 for the .introduction of discs of heavy metal (tungsten, lead, for
- the coupling member 4 of lightweight material which is transparent to X-rays makes it possible during the application to maintain the uterine probe 1 and the vaginal probes 2 and 3 in a strictly geometrical position.
- a radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of nonradioactive preparation, wherein said applicator comprises a tubular uterine probe and two tubular vaginal probes, a coupling member constituted by a polyhedral block formed of a low density material transparent to X-rays, said block being provided with a central passageway for receiving the uterine probe and with two oblique passageways which are symmetrical with respect to said central passageway for receiving the two vagina] probes, and two cylindrical plugs each traversed by a passageway through which the vaginal probes extend, said plugs being in contact with said coupling member, said coupling member being provided with hollowed-out portions in the form of cylindrical cups corresponding in shape to said plugs and each located at one extremity of a vaginal-probe passageway, said plugs adapted to rest in said hollowed-out portions, the direction of the longitudinal axes of said cylindrical cups being inclined to the direction
- each vaginal probe is sealed by means of an added end-cap.
- each plug includes two removable end-caps permitting the introduction of discs of heavy metal.
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Radiation-Therapy Devices (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR717114933A FR2147769B1 (ja) | 1971-04-27 | 1971-04-27 | |
CH562272A CH546581A (fr) | 1971-04-27 | 1972-04-17 | Applicateur de sources radioactives pour plesiocurietherapie utero-vaginale en preparation non radioactive. |
GB1809972A GB1382098A (en) | 1971-04-27 | 1972-04-19 | Radioactive source applicator for utero-vaginal piesiocurietherapy |
US00245945A US3807386A (en) | 1971-04-27 | 1972-04-20 | Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation |
DE19722220527 DE2220527A1 (de) | 1971-04-27 | 1972-04-26 | Strahlenquellen-Applikator mit nichtradioaktiver Präparation für Utero-Vaginal-Plesiocurie-Therapie |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR717114933A FR2147769B1 (ja) | 1971-04-27 | 1971-04-27 | |
US00245945A US3807386A (en) | 1971-04-27 | 1972-04-20 | Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
US3807386A true US3807386A (en) | 1974-04-30 |
Family
ID=37398919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00245945A Expired - Lifetime US3807386A (en) | 1971-04-27 | 1972-04-20 | Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US3807386A (ja) |
CH (1) | CH546581A (ja) |
DE (1) | DE2220527A1 (ja) |
FR (1) | FR2147769B1 (ja) |
GB (1) | GB1382098A (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970073A (en) * | 1975-01-30 | 1976-07-20 | Howlin Enterprises, Inc. | Positioning device for radiation treatment of cervical carcinoma |
US4331131A (en) * | 1979-12-17 | 1982-05-25 | The Board Of Regents Of The University Of Nebraska | Method for treating carcinoma of the uterine cervix |
US4554909A (en) * | 1983-05-27 | 1985-11-26 | Pino Y Torres Jose L | Vaginal applicator |
US5012357A (en) * | 1989-03-20 | 1991-04-30 | University Of Michigan | CT compatible intracavity radiation applicator with afterloading shielding |
US5562594A (en) * | 1994-06-10 | 1996-10-08 | Duke University | Shielded mini-applicator system for radioactive source treatment of cancer of the uterine cervix |
WO2001080951A1 (en) * | 2000-04-24 | 2001-11-01 | The University Of Miami | Multicomponent vaginal cylinder system for low dose rate brachytherapy of gynecological cancers |
US6312375B1 (en) | 1998-08-07 | 2001-11-06 | Joseph F. Montebello | Inflatable covering for tandem colpostat intracavitary implant |
NL1031785C2 (nl) * | 2006-05-10 | 2007-11-13 | Isodose Control Intellectual P | Gynaecologisch instrument. |
US20090326314A1 (en) * | 2005-12-16 | 2009-12-31 | Cutrer L Michael | Brachytherapy apparatus for asymmetrical body cavities |
US8137256B2 (en) | 2005-12-16 | 2012-03-20 | Portola Medical, Inc. | Brachytherapy apparatus |
US20130006097A1 (en) * | 2011-07-01 | 2013-01-03 | Mick Felix W | Bladder and/or Rectum Extender with Exchangeable and/or Slideable Tungsten Shield |
WO2013016701A1 (en) * | 2011-07-27 | 2013-01-31 | Mick Radio-Nuclear Instruments, Inc. | Bladder and/or rectum extender with exchangeable and/or slideable tungsten shield |
US20130053682A1 (en) * | 2011-08-31 | 2013-02-28 | Jacqueline Esthappan | Gynecological brachytherapy applicator for use in mr-guided intracavitary brachytherapy |
CN110975175A (zh) * | 2020-01-06 | 2020-04-10 | 温州市中心医院 | 一种妇科肿瘤腔内放射治疗防护装置 |
US11491346B2 (en) * | 2009-07-24 | 2022-11-08 | Voxel Rad, Ltd. | Systems and methods for treating cancer using brachytherapy |
US11617503B2 (en) | 2018-12-12 | 2023-04-04 | Voxel Rad, Ltd. | Systems and methods for treating cancer using brachytherapy |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2763508B1 (fr) * | 1997-05-21 | 1999-07-23 | Perouse Implant Lab | Dispositif intravaginal d'irradiation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2106433A (en) * | 1936-11-16 | 1938-01-25 | William E Morse | Distension douche |
US2516261A (en) * | 1948-05-21 | 1950-07-25 | Bernhard F Schutt | Cervical-uterine applicator |
DE875997C (de) * | 1951-06-26 | 1953-05-07 | Hans Joachim V Dr Med Held | Radiologisches Bestrahlungsgeraet zur Behandlung von Krebs-erkrankungen im Beckenbindegewebe von Frauen |
US3060924A (en) * | 1960-06-01 | 1962-10-30 | Joseph C Rush | Apparatus for application of radioactive substance to pelvic cancer |
-
1971
- 1971-04-27 FR FR717114933A patent/FR2147769B1/fr not_active Expired
-
1972
- 1972-04-17 CH CH562272A patent/CH546581A/fr not_active IP Right Cessation
- 1972-04-19 GB GB1809972A patent/GB1382098A/en not_active Expired
- 1972-04-20 US US00245945A patent/US3807386A/en not_active Expired - Lifetime
- 1972-04-26 DE DE19722220527 patent/DE2220527A1/de active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2106433A (en) * | 1936-11-16 | 1938-01-25 | William E Morse | Distension douche |
US2516261A (en) * | 1948-05-21 | 1950-07-25 | Bernhard F Schutt | Cervical-uterine applicator |
DE875997C (de) * | 1951-06-26 | 1953-05-07 | Hans Joachim V Dr Med Held | Radiologisches Bestrahlungsgeraet zur Behandlung von Krebs-erkrankungen im Beckenbindegewebe von Frauen |
US3060924A (en) * | 1960-06-01 | 1962-10-30 | Joseph C Rush | Apparatus for application of radioactive substance to pelvic cancer |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970073A (en) * | 1975-01-30 | 1976-07-20 | Howlin Enterprises, Inc. | Positioning device for radiation treatment of cervical carcinoma |
US4331131A (en) * | 1979-12-17 | 1982-05-25 | The Board Of Regents Of The University Of Nebraska | Method for treating carcinoma of the uterine cervix |
US4554909A (en) * | 1983-05-27 | 1985-11-26 | Pino Y Torres Jose L | Vaginal applicator |
US5012357A (en) * | 1989-03-20 | 1991-04-30 | University Of Michigan | CT compatible intracavity radiation applicator with afterloading shielding |
US5562594A (en) * | 1994-06-10 | 1996-10-08 | Duke University | Shielded mini-applicator system for radioactive source treatment of cancer of the uterine cervix |
US6312375B1 (en) | 1998-08-07 | 2001-11-06 | Joseph F. Montebello | Inflatable covering for tandem colpostat intracavitary implant |
WO2001080951A1 (en) * | 2000-04-24 | 2001-11-01 | The University Of Miami | Multicomponent vaginal cylinder system for low dose rate brachytherapy of gynecological cancers |
US6641518B2 (en) | 2000-04-24 | 2003-11-04 | The University Of Miami | Multicomponent vaginal cylinder system for low dose rate brachytherapy or gynecological cancers |
US20090326314A1 (en) * | 2005-12-16 | 2009-12-31 | Cutrer L Michael | Brachytherapy apparatus for asymmetrical body cavities |
US8226539B2 (en) | 2005-12-16 | 2012-07-24 | Portola Medical, Inc. | Brachytherapy apparatus for asymmetrical body cavities |
US8137256B2 (en) | 2005-12-16 | 2012-03-20 | Portola Medical, Inc. | Brachytherapy apparatus |
US20070276177A1 (en) * | 2006-05-10 | 2007-11-29 | Isodose Control Intellectual Property B.V. | Gynecological Instrument |
US7871365B2 (en) | 2006-05-10 | 2011-01-18 | Isodose Control Intellectual Property, B.V. | Gynecological instrument |
EP1854507A1 (en) * | 2006-05-10 | 2007-11-14 | Isodose Control Intellectual Property B.V. | Gynecological instrument for brachytherapy |
NL1031785C2 (nl) * | 2006-05-10 | 2007-11-13 | Isodose Control Intellectual P | Gynaecologisch instrument. |
US11491346B2 (en) * | 2009-07-24 | 2022-11-08 | Voxel Rad, Ltd. | Systems and methods for treating cancer using brachytherapy |
US20130006097A1 (en) * | 2011-07-01 | 2013-01-03 | Mick Felix W | Bladder and/or Rectum Extender with Exchangeable and/or Slideable Tungsten Shield |
US9345907B2 (en) * | 2011-07-01 | 2016-05-24 | Mick Radio-Nuclear Instruments, Inc. | Bladder and/or rectum extender with exchangeable and/or slideable tungsten shield |
WO2013016701A1 (en) * | 2011-07-27 | 2013-01-31 | Mick Radio-Nuclear Instruments, Inc. | Bladder and/or rectum extender with exchangeable and/or slideable tungsten shield |
US20130053682A1 (en) * | 2011-08-31 | 2013-02-28 | Jacqueline Esthappan | Gynecological brachytherapy applicator for use in mr-guided intracavitary brachytherapy |
US9248310B2 (en) * | 2011-08-31 | 2016-02-02 | Washington University | Gynecological brachytherapy applicator for use in MR-guided intracavitary brachytherapy |
US11617503B2 (en) | 2018-12-12 | 2023-04-04 | Voxel Rad, Ltd. | Systems and methods for treating cancer using brachytherapy |
CN110975175A (zh) * | 2020-01-06 | 2020-04-10 | 温州市中心医院 | 一种妇科肿瘤腔内放射治疗防护装置 |
Also Published As
Publication number | Publication date |
---|---|
DE2220527A1 (de) | 1972-11-09 |
FR2147769B1 (ja) | 1974-06-21 |
CH546581A (fr) | 1974-03-15 |
GB1382098A (en) | 1975-01-29 |
FR2147769A1 (ja) | 1973-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: COMPAGNIE ORIS INDUSTRIE, S.A., 31-33 RUE DE LA FE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:COMMISSARIAT A L ENERGIE ATOMIQUE;REEL/FRAME:004611/0265 Effective date: 19860905 Owner name: COMPAGNIE ORIS INDUSTRIE, S.A., 31-33 RUE DE LA FE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COMMISSARIAT A L ENERGIE ATOMIQUE;REEL/FRAME:004611/0265 Effective date: 19860905 |