US3805767A - Method and apparatus for non-surgical, reversible sterilization of females - Google Patents

Method and apparatus for non-surgical, reversible sterilization of females Download PDF

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Publication number
US3805767A
US3805767A US00335816A US33581673A US3805767A US 3805767 A US3805767 A US 3805767A US 00335816 A US00335816 A US 00335816A US 33581673 A US33581673 A US 33581673A US 3805767 A US3805767 A US 3805767A
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US
United States
Prior art keywords
oviduct
tip
tip member
terminal end
block
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00335816A
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English (en)
Inventor
R Erb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Franklin Institute
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US00335816A priority Critical patent/US3805767A/en
Priority to ZA740931A priority patent/ZA74931B/xx
Priority to IL44203A priority patent/IL44203A/en
Priority to DE19742407652 priority patent/DE2407652C3/de
Priority to SE7402428A priority patent/SE419698B/xx
Priority to GB825174A priority patent/GB1430045A/en
Priority to BR741387A priority patent/BR7401387D0/pt
Priority to CA193,336A priority patent/CA1046372A/fr
Priority to JP49022743A priority patent/JPS5239595B2/ja
Priority to BE141359A priority patent/BE811539A/fr
Priority to FR7406289A priority patent/FR2218907B1/fr
Priority to NL747402502A priority patent/NL154660B/xx
Priority to IT48696/74A priority patent/IT1015818B/it
Priority to CH270874A priority patent/CH578876A5/xx
Priority to AU66031/74A priority patent/AU465515B2/en
Application granted granted Critical
Publication of US3805767A publication Critical patent/US3805767A/en
Priority to US05/679,185 priority patent/USRE29345E/en
Priority to CA313,134A priority patent/CA1062110A/fr
Assigned to CALSPAN CORPORATION reassignment CALSPAN CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: FRANKLIN INSTITUTE
Assigned to FRANKLIN INSTITUTE reassignment FRANKLIN INSTITUTE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: CALSPAN CORPORATION, AN OH CORP.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/20—Vas deferens occluders; Fallopian occluders
    • A61F6/22—Vas deferens occluders; Fallopian occluders implantable in tubes
    • A61F6/225—Vas deferens occluders; Fallopian occluders implantable in tubes transcervical

Definitions

  • the tip is, aligned with the uterine end of the oviduct.
  • a curable elastomeric composition is injected, through an aperture in the tip, into the oviduct in an amount sufficient to fill the portion of the oviduct adjacent to the uterus.
  • the elastomeric composition is allowed to solidify and adhere to the above noted tip.
  • the apparatus is then removed with the tip being ejected from the apparatus so as to remain adhered to the resulting oviduct block.
  • the above procedure is repeated. for the opposite oviduct.
  • the resulting oviduct blocks prevent the passage of ovum from the ovaries to the uterus and sperm from entering'the oviduct thereby preventing conception.
  • the oviduct blocks if desired can be removed non-surgically by utilizing an apparatus whichgrips the tip portion of the oviduct block and extracts the entire oviduct block from the oviduct.
  • the ideal contraception method should be 100 percent effective in preventing conception; should not rely on willpower; should not interfere with the satisfaction of sexual relationships, and should be low in cost taking into consideration the effective life of the contraceptive method.
  • the contraceptive method must not have any harmful psychological side effects.
  • An extremely important feature of an ideal contraceptive method especially for family planning is that it be reversible so that it will be possible to have additional children if desired.
  • a method and apparatus is provided to form oviduct blocks which prevent conception when in place and can be nonsurgically removed if desires.
  • the apparatus is inserted through the cervical os into the uterus.
  • the tip on the apparatus is then aligned with the uterine end of the oviduct.
  • a mixture of a fluid elastomeric material and a catalyst for polymerizing the elastomeric mixture is injected through an aperture in the tip into the oviduct.
  • the elastomeric material is allowed to solidify and to adhere to the tip.
  • the tip is released so that it remains with the injected elastomeric material to form the oviduct block of this invention.
  • the apparatus is then removed.
  • the oviduct block can be removed nonsurgically by inserting an instrument into the uterus through the cervix which grips the tip of the oviduct block and then withdrawing the oviduct block which restores normal fertility.
  • FIG. 1 is an illustration in partial cross-section of an apparatus especially adopted for use in the method of this invention.
  • FIG. 2 is an illustration in partial cross-section of a uterus, the cervix and a portion of the vagina.
  • the uterus is illustrated with an oviduct block insert in one of the oviduct and the terminal end of the apparatus of FIG. 1 positioned for insertion of an oviduct block into the opposite oviduct.
  • FIG. 3 is an enlarged illustration taken in partial cross-section of the terminal end of the apparatus of FIG. 1.
  • FIG. 4 is an illustration in cross-section of the terminal end of the apparatus of FIG. 3 shown with fluid uncured elastomeric material shown in the internal feed tube.
  • FIG. 5 is an illustration shown in cross-section showing the separation of the tip from the apparatus of FIG. 1.
  • an oviduct block is formed in situ in the oviduct.
  • the oviduct block is most preferable formed from a medical inert plastic which has approximately the same modulus of elasticity as the oviduct.
  • the selection of material having the proper modulus of elasticity appears to both' prevent cxplusion of the oviduct block and substantially eliminates any physical discomfort.
  • the materials which have been found most useful in the method of this invention are the commercially available medical grade silicone elastomers.
  • the uncured silicone elastomer in the fluid state is blended with a catalyst for solidifying the elastomer and a dilution fluid to control the viscosity during injection and also to control the modulus of elasticity of the cured solidified material. It is preferable to also include a radiopaque material in the mixture to facilitate the placement of the oviduct block and to facilitate removal of the oviduct block if desires.
  • a tip is molded from an inert plastic material to which the injected elastomeric material will adhere on solidification.
  • silicone-rubber is ideally suited for this purpose when a silicone elastomer is used for formation of the oviduct block.
  • the portion of the tip 10 which will be in contact with uterine end of the oviduct 12 has a spherical configuration.
  • the tip 10 has an aperture 14 which extends throughout the entire length of the tip 14.
  • the tip as illustrated has a-series of annular piston rings 16 molded into the interior portion surface of the aperture 14.
  • the tip 10 further includes a loop 18 which is preferably a thread of a material which is inert in uterine fluids, such as nylon.
  • the apparatus 20 shown in FIG. 1 is specifically designed for use in the method of this invention.
  • the apparatus 20 includes a tubular extension 22, a dispensing apparatus 24, and a control handle 26 for both operating the dispensing means and positioning the tip 10 on the end of the tubular extension 22.
  • the tubular extension 22 has a rigid section which is adjacent to the control handle 26.
  • the opposite terminal end portion 28 on which the tip 10 is secured is flexible.
  • One end of each control wire 30, 32 is attached to the end portion of the flexible section 28.
  • the control wires 30, 32 are connected at their opposite ends to a pair of separately controlled drums 34 (only one drum is shown) mounted on the control hand 26. By adjustment of the drums 34 to either to collect or release the wires 30, 32 the position of the tip 10 can be adjusted and bent in a curved configuration shown in FIG. 2.
  • a metal connector 36 ' is provided which has annular piston ring 38 which mates with the piston rings 16 on the tip 10.
  • the metal connector '36 further has defined in it a constricted area having a sharp cut off portion 40.
  • a tube 42 extends from the dispensing means 24, through the tubular extension 22 to the aperture 14 in the tip 10.
  • the dispensing means 24 consists of a mixing syringe 44 in which the plunger 46 is adapted to provide mixing of a fluid elastermeric material, a catalyst and other additive as may be required.
  • the syringe 44 is mounted on top of the control handle 26 with the plunger 46 in contact with a rack 48 and a pivotal mounted pawl 50.
  • the pawl 50 is connected to a trigger 52. Squeezing the trigger 52 causes the plunger 46 to be advanced within the syringe 46 and material within thesyringe 44 to be dispensed through the tube 42 to the tip 10.
  • the tip 10 is inserted over the end of the flexible portion 28 of the tubular extension.
  • the tip 10 being premolded of asilicone rubher is somewhat elastic and deforms somewhat until the piston ring 16 of the tip of 10 engages and locks with the mating piston rings 38.
  • the tubular extension 20 with tip 10 installed is inserted into the vagina 54, through the cervical os 56 into the uterine cavity 58. Then, preferably using flouroscopic techniques, the tip 10 is aligned with the uterine end of one of the oviducts 12. It should be noted that because of the shape of the uterine cavity 58 thetip can be guided blindly in the proper position. The relative position of the flexible end 28 is controlled by adjustment of the drums 34.
  • the fluid mixture of the elastomer, catalyst and other additives are injected through the tube 42 to the tip 10 by operation of the trigger 52 as noted above.
  • the uncured fluid elastomeric mixture 60 flows through the aperture 14 in the tip 10 and then into the oviduct 12.
  • a sufficient amount of the mixture is injected to fill approximately one third or more of the length of the oviduct 12.
  • Some of the material will flow back around the tip 10 so that the surface of the tip 10 will conform to the shape of the uterine end of the oviduct 12 as shown in the tip 10 as modified 62 which is shown in FIG. 5.
  • the solidified oviduct blocks each has a configuration which conforms to the interior of the oviduct in which it is cast, thus effectively preventing conception.
  • the oviduct block can remain in place until it is desired to remove it.
  • the use of a material having approximately the same modulus of elasticity as the oviducts assists in maintaining the oviduct blocks 64 in position.
  • the natural convolution of the oviduct likewise results in stabilization of the oviduct blocks 64.
  • the tip 10 serves a most important function of preventing the oviduct block 64 from migrating into the intraperitoneal cavity, a problem that was a serious and relatively common problem with othersimilar prior art technique.
  • the oviduct block is inserted nonsurgically.
  • the method is relatively simple to learn by those skilled in the medical art.
  • the time required is likewise quite short with a skilled person being able to block both oviducts in about 15 to 30 minutes.
  • the oviduct block can be removed nonsurgically if desired.
  • An instrument of the type shown in FIG. 1 is used for this purpose.
  • the tip 10 is replaced with a hooked member which is adapted to engage the loop 18. Once the loop 18 is engaged the oviduct block 64 is withdrawn. It is also possible to use a pronged member to grip the tip and then pull out the oviduct block.
  • Both the insertion and removal of the oviduct block 64 are relatively painless. However a local anesthetic can be used if desired.
  • the effectiveness of the contraception method of this invention was found to be excellent. On rabbit tests it was found that the method is 100% effective if the oviduct blocks are properly placed. In further rabbit tests it was found that after the oviduct blocks were removed that fertility was restored. There was no indication of explusion of the oviduct blocks either in the uterine cavity or in the int'raperitoneal cavity. Histologic examv, ination and scanning election microscopic examination have not indicated that there is any adverse reaction to the tissue of the oviducts.
  • control handle 26 has been provided to sisting of the trigger 52, rack 48 and pawl 50, could likewise be removed and the syringe operated manually.
  • configuration of the tip 10 can be modified to a different shape such as a conical configuration of other suitable shapes and still be satisfactory for use in this invention.
  • I claim: 1. The method of forming non-surgically removable oviduct block in a female comprising the step of a. providing a shaped tip member having an aperture defined therein; said tip memlber having a configuration such as to fit in substantial sealing contact adjacent to the uterine end of the oviduct of said female, and having a size larger than the lumen of said oviduct; said tip member being formed from a given cured elastomeric material b. positioning said tip member within the uterine cavity of said female adjacent to the uterine end of said oviduct with the aperture of said tip member being in axial alignment with the lumen of said oviduct c.
  • said tip member further includes a loop member whereby said loop member can be gripped to non-surgically remove said oviduct block.
  • the apparatus for forming the oviduct block according to claim 1, said apparatus comprising: a tubular means of a length sufficient to extend from vagina area of said female to the uterine ends of said oviducts and having a diameter sufficiently small to pass through the cervix of said female; said tubular means having first and second terminal ends; said first terminal end having an apertured tip member detachably connected thereto and also means for releaseably holding and ejecting said tip member, said tubular member including means for positioning said first terminal end with said tip member thereon adjacent the uterine end of said oviduct, and said tubular member further including means for transmission of said self curing elastomeric material from a point adjacent to the second terminal end toand through said aperture in said 'tip member secured to the first terminal end.
  • dispensing means is a syringe having a barrel and a plunger and wherein the plunger is advanceable within the barrel by a rack and paw] drive operated from the second terminal end.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
US00335816A 1973-02-26 1973-02-26 Method and apparatus for non-surgical, reversible sterilization of females Expired - Lifetime US3805767A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US00335816A US3805767A (en) 1973-02-26 1973-02-26 Method and apparatus for non-surgical, reversible sterilization of females
ZA740931A ZA74931B (en) 1973-02-26 1974-02-12 Method and apparatus for non-surgical,reversible sterilization of females
IL44203A IL44203A (en) 1973-02-26 1974-02-14 Device for reversible non-surgical sterilization of females
DE19742407652 DE2407652C3 (de) 1973-02-26 1974-02-18 Nicht- chirurgisch entfernbarer Eileiter-Verschluß und Vorrichtung zu seiner Einführung
GB825174A GB1430045A (en) 1973-02-26 1974-02-22 Contraceptive apparatus and method
BR741387A BR7401387D0 (pt) 1973-02-26 1974-02-22 Processo para a aplicacao de um dispositivo anticonceptional feminino e respectivo dispositivo
SE7402428A SE419698B (sv) 1973-02-26 1974-02-22 Medelst en apparat manipulerbar anordning for astadkommande av ett eggledarblock samt apparat for manipulering av anordningen
FR7406289A FR2218907B1 (fr) 1973-02-26 1974-02-25
JP49022743A JPS5239595B2 (fr) 1973-02-26 1974-02-25
BE141359A BE811539A (fr) 1973-02-26 1974-02-25 Appareil et procede de contraception
CA193,336A CA1046372A (fr) 1973-02-26 1974-02-25 Methode et appareil pour la sterilisation reversible et non chirurgicale des femmes
NL747402502A NL154660B (nl) 1973-02-26 1974-02-25 Apparaat voor het inbrengen van een blokkeringsmiddel in een eileider.
IT48696/74A IT1015818B (it) 1973-02-26 1974-02-25 Apparecchio per la sterilizzazio ne reversibile non chirurgica di femmine
AU66031/74A AU465515B2 (en) 1973-02-26 1974-02-26 Method and apparatus for nonsurgical reversible sterilization of females
CH270874A CH578876A5 (fr) 1973-02-26 1974-02-26
US05/679,185 USRE29345E (en) 1973-02-26 1976-04-22 Method and apparatus for non-surgical, reversible sterilization of females
CA313,134A CA1062110A (fr) 1973-02-26 1978-10-11 Dispositif intra-uterin et methode d'installation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00335816A US3805767A (en) 1973-02-26 1973-02-26 Method and apparatus for non-surgical, reversible sterilization of females

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US05/679,185 Reissue USRE29345E (en) 1973-02-26 1976-04-22 Method and apparatus for non-surgical, reversible sterilization of females

Publications (1)

Publication Number Publication Date
US3805767A true US3805767A (en) 1974-04-23

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Application Number Title Priority Date Filing Date
US00335816A Expired - Lifetime US3805767A (en) 1973-02-26 1973-02-26 Method and apparatus for non-surgical, reversible sterilization of females

Country Status (14)

Country Link
US (1) US3805767A (fr)
JP (1) JPS5239595B2 (fr)
AU (1) AU465515B2 (fr)
BE (1) BE811539A (fr)
BR (1) BR7401387D0 (fr)
CA (1) CA1046372A (fr)
CH (1) CH578876A5 (fr)
FR (1) FR2218907B1 (fr)
GB (1) GB1430045A (fr)
IL (1) IL44203A (fr)
IT (1) IT1015818B (fr)
NL (1) NL154660B (fr)
SE (1) SE419698B (fr)
ZA (1) ZA74931B (fr)

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US3875939A (en) * 1974-01-31 1975-04-08 Population Res Inc Single stroke dispensing method
US3918431A (en) * 1974-01-11 1975-11-11 Manfred Sinnreich Fallopian tube obturating device
US3948259A (en) * 1973-03-09 1976-04-06 Population Research Incorporated Dispensing instrument
US3972331A (en) * 1973-03-09 1976-08-03 Population Research Incorporated Dispensing catheter
DE2411242C3 (de) 1973-03-09 1980-01-31 Population Research Inc., Minneapolis, Minn. (V.St.A.) Instrument zum Einbringen von Stoffen in die Eileiterkanäle
EP0010812A1 (fr) * 1978-10-26 1980-05-14 Karel Johan Hendrik Verschoof Dispositif contraceptif
US4245623A (en) * 1978-06-06 1981-01-20 Erb Robert A Method and apparatus for the hysteroscopic non-surgical sterilization of females
US4271845A (en) * 1978-07-01 1981-06-09 Kabushiki Kaisha Medos Kenkyusho Device for bending a medical instrument inserted into the body cavity
US4273131A (en) * 1979-06-18 1981-06-16 Auburn Enterprises, Inc. Surgical stylet
US4363318A (en) * 1979-12-31 1982-12-14 University Patents, Inc. Custom valved cervical cap
US4365632A (en) * 1978-05-05 1982-12-28 Kortum William M Method and apparatus for inducing immunological and resistant response in mammary glands
US4446578A (en) * 1982-03-08 1984-05-08 Perkins Ezra C Joint treatment
US4601698A (en) * 1984-09-17 1986-07-22 Moulding Jr Thomas S Method of and instrument for injecting a fluid into a uterine cavity and for dispersing the fluid into the fallopian tubes
US4637818A (en) * 1983-11-25 1987-01-20 Johnson Richard K Apparatus for producing sterility in female animals
US4700701A (en) * 1985-10-23 1987-10-20 Montaldi David H Sterilization method and apparatus
US4805618A (en) * 1985-08-08 1989-02-21 Olympus Optical Co., Ltd. Oviduct closing apparatus
US5217466A (en) * 1991-04-19 1993-06-08 Hasson Harrith M Guide for facilitating the performance of internal surgery
US5342394A (en) * 1990-05-16 1994-08-30 Olympus Optical Co., Ltd. Apparatus for blocking a vein branch and method of blocking a vein branch
US5368598A (en) * 1991-04-19 1994-11-29 Hasson; Harrith M. Method of manipulating an uterus using a bendable manipulator
US5555896A (en) * 1994-09-26 1996-09-17 Cimber; Hugo Intrauterine contraceptive device
WO1996040023A1 (fr) * 1995-06-07 1996-12-19 Conceptus, Inc. Dispositifs contraceptifs d'occlusion de la trompe de fallope par le col de l'uterus et leur mise en place
WO1996040024A1 (fr) * 1995-06-07 1996-12-19 Conceptus, Inc. Dispositifs contraceptifs d'occlusion de la trompe de fallope par le canal cervical, a fixation mecanique a la trompe
US5795353A (en) * 1994-05-06 1998-08-18 Advanced Bio Surfaces, Inc. Joint resurfacing system
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NL185264C (nl) * 1978-01-27 1990-03-01 Medline Ab Middel voor het ten minste tijdelijk blokkeren van kanalen of holle ruimten in mensen of dieren.
GB2150032B (en) * 1983-11-25 1988-01-06 Richard K Johnson Method of producing sterility in female animals
AU781739B2 (en) * 1999-08-23 2005-06-09 Bayer Essure Inc. Deployment actuation system for intrafallopian contraception
AT503419B1 (de) * 2006-06-08 2007-10-15 Hans-Peter Dr Steiner Dosiereinrichtung für den uterinen embryotransfer

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DE2407652B2 (de) 1976-01-15
AU6603174A (en) 1975-08-28
DE2407652A1 (de) 1974-09-12
BR7401387D0 (pt) 1974-11-05
SE419698B (sv) 1981-08-24
BE811539A (fr) 1974-06-17
JPS5239595B2 (fr) 1977-10-06
AU465515B2 (en) 1975-10-02
NL154660B (nl) 1977-10-17
GB1430045A (en) 1976-03-31
FR2218907B1 (fr) 1978-07-21
CA1046372A (fr) 1979-01-16
NL7402502A (fr) 1974-08-28
ZA74931B (en) 1974-12-24
IL44203A0 (en) 1974-05-16
IL44203A (en) 1977-03-31
FR2218907A1 (fr) 1974-09-20
IT1015818B (it) 1977-05-20
CH578876A5 (fr) 1976-08-31
JPS49135486A (fr) 1974-12-26

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Effective date: 19860604

Owner name: FRANKLIN INSTITUTE, PENNSYLVANIA

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Effective date: 19860604