US3779706A - Process for bulk sterilization, minimizing chemical and physical damage - Google Patents
Process for bulk sterilization, minimizing chemical and physical damage Download PDFInfo
- Publication number
- US3779706A US3779706A US00186427A US3779706DA US3779706A US 3779706 A US3779706 A US 3779706A US 00186427 A US00186427 A US 00186427A US 3779706D A US3779706D A US 3779706DA US 3779706 A US3779706 A US 3779706A
- Authority
- US
- United States
- Prior art keywords
- sterilization
- rads
- damage
- physical damage
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000008569 process Effects 0.000 title claims description 19
- 239000000126 substance Substances 0.000 title abstract description 24
- 230000006378 damage Effects 0.000 title abstract description 20
- 230000001954 sterilising effect Effects 0.000 title description 21
- 238000004659 sterilization and disinfection Methods 0.000 title description 20
- 238000010894 electron beam technology Methods 0.000 claims abstract description 17
- 210000004369 blood Anatomy 0.000 claims description 4
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- 229940088598 enzyme Drugs 0.000 description 5
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- 244000005706 microflora Species 0.000 description 3
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- 235000008939 whole milk Nutrition 0.000 description 3
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
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- 229910052708 sodium Inorganic materials 0.000 description 2
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- PDXOPTFTOFXXSU-UHFFFAOYSA-N 1-sulfanylpentan-1-ol Chemical compound CCCCC(O)S PDXOPTFTOFXXSU-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000194103 Bacillus pumilus Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 241000192091 Deinococcus radiodurans Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical group NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
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- 230000001066 destructive effect Effects 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 229940106780 human fibrinogen Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229940119528 pork insulin Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
Definitions
- the invention teaches new methods of sterilizing and preserving substances whereby the destruction or inactivation of harmful or undesirable micro-organisms can be conducted without causing significant damage or other del eterious effects in the host or carrier medium, including bacteria, virus, yeasts, molds, enzymes and a number of other radiation-sensitive chemicals and protein-rich materials, including blood serum.
- An object of the invention accordingly, is to provide a new and improved process of electron-beam sterilization or irradiation, not subject to the disadvantages, before discussed, but effective without damage to the irradiated substance structure.
- a further object is to provide a novel electron-beam technique of more general applicability, as well.
- the invention contemplates a process for bulk sterilization involving selectively destroying viable micro-organisms and the like in a medium, such as cellulose-containing products, blood, pharmaceuticals, cosmetics, foodstuffs and other substances, but without effecting substantial chemical and physical damage to the media, that comprises, disposing a medium to-be-sterilized at a predetermined region, generating pulsed substantially monochromatic electron beam energy and directing the same to said region substantially uniformly to irradiate the medium, and adjusting the pulses of energy to produce an irradiation dose of value within the range of from substantially a few tenths to several megarads and with a dose rate greater than substantially l0 rads per second.
- a medium such as cellulose-containing products, blood, pharmaceuticals, cosmetics, foodstuffs and other substances
- substantial chemical and physical damage to the media that comprises, disposing a medium to-be-sterilized at a predetermined region, generating pulsed substantially monochromatic electron beam energy and directing the same
- typical dose rates here-employed are of the order of 4 X 10" rads/second.
- Ultraviolet spectroscopic evaluation of the material was used to determine the degree of damage to the active benzyl ammonium group; and the structures in the 2,000-2,200 A and in the 2,500-2,800 A regions characteristic of the benzylammonium radical demonstrated severe damage under low rate (C0 irradiation and negligible change under the high rate (electron) treatment of the invention.
- the decreased chemical damage associated with the high rate electron beam treatment of the invention bears out the results of other experiments, moreover, particularly with proteins. It appears that the rapid quenching of the free radicals formed during the radiation pulse or bursts, ameliorates (in fact may eliminate) secondary damage effects in the system; while those primary damage mechanisms which dominate the bactericidal action are unaltered.
- the extensive lethality studies described with vegetative bacteria, aerobic spore formers, enzymes and virus have confirmed this latter effect; i.e., that the dose required to reduce the micro-organism population by a factor of ten varies little with rate in some cases it has been found to decrease.
- the radiation sensitivities of bacteria and microflora are known to be very dependent upon environment, notably oxygen availability. It is for this reason that parallel comparative studies were performed.
- Plasma proteins and their fractions have been used for diagnostic and therapeutic purposes for many years. Since they are usually used parenterally, a sterile preparation is required. Conventional methods for protein sterilization are not completely satisfactory due to loss of proteins and their relative ineffectiveness in preventing virus contamination. The application of the present electron sterilization for cold treatment of proteins can eliminate losses currently involved in the filtration techniques commonly used. Results from comparative experiments on human fibrinogen and human plasma showed that significant reduction in the destruction of clottable protein in these blood fractions is attainable by the invention (l0 rads/second), as compared with the rads/second treatment level for Co.
- the invention has provided a process whereby materials sensitive to heat or hydrolysis can readily be sterilized without physio-chemical damage to the treated compound.
- a process for bulk sterilization involving selectively destroying viable micro-organisms and the like in a medium but without effecting substantial chemical and physical damage to the medium that comprises, disposing a medium-to-be-sterilized at a predetermined region, said medium being selected of sample thickness of the order of approximately one gram per square centimeter and under, generating pulsed substantially monochromatic electron beams and directing the same to said region substantially uniformly to irradiate the medium, and adjusting the pulses of electron beam energy to produce an irradiation dose of value within the range of from substantially a few tenths to several megarads and with a dose rate greater than substantially l0 rads per second.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Catching Or Destruction (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18642771A | 1971-10-04 | 1971-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3779706A true US3779706A (en) | 1973-12-18 |
Family
ID=22684914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US00186427A Expired - Lifetime US3779706A (en) | 1971-10-04 | 1971-10-04 | Process for bulk sterilization, minimizing chemical and physical damage |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3779706A (cs) |
| JP (1) | JPS5235236B2 (cs) |
| CA (1) | CA963984A (cs) |
| DE (1) | DE2249190C3 (cs) |
| FR (1) | FR2155980B1 (cs) |
| GB (1) | GB1361300A (cs) |
| IT (1) | IT986850B (cs) |
| SE (1) | SE385539B (cs) |
| SU (1) | SU603321A3 (cs) |
Cited By (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901807A (en) * | 1973-06-27 | 1975-08-26 | High Voltage Engineering Corp | High energy electron treatment of water |
| US4246295A (en) * | 1978-09-15 | 1981-01-20 | Crihan Ioan G | Sterilization and structural reinforcement of art objects made of organic material |
| US4367412A (en) * | 1978-11-03 | 1983-01-04 | Tetra Pak Developpement Sa | Process of and apparatus for cold-cathode electron-beam generation for sterilization of surfaces and similar applications |
| US4439686A (en) * | 1980-09-16 | 1984-03-27 | Tetra Pak Developpement Ltd. | Electron beam-irradiating apparatus with conical bushing seal-support |
| US4620908A (en) * | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
| US5096553A (en) * | 1986-09-11 | 1992-03-17 | Ionizing Energy Company Of Canada Limited | Treatment of raw animal hides and skins |
| US5250257A (en) * | 1990-06-20 | 1993-10-05 | Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh | Process for the sterilization of implants |
| US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5489783A (en) * | 1993-04-28 | 1996-02-06 | Tetra Laval Holdings & Finance S.A. | Electron accelerator for sterilizing packaging material in an aspetic packaging machine |
| US5989498A (en) * | 1994-03-04 | 1999-11-23 | St. Jude Medical, Inc. | Electron-beam sterilization of biological materials |
| US5998155A (en) * | 1995-11-09 | 1999-12-07 | E.R. Squibb & Sons, Inc. | Stable composition of immobilized protein having affinity for biotin |
| US6187572B1 (en) | 1990-04-16 | 2001-02-13 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
| US20030031584A1 (en) * | 2001-08-10 | 2003-02-13 | Wilson Burgess | Methods for sterilizing biological materials using dipeptide stabilizers |
| US6524528B1 (en) * | 1999-03-02 | 2003-02-25 | Suzanne C. Gottuso | Method of sterilizing a tattooing solution through irradiation |
| US6551794B1 (en) * | 1995-11-09 | 2003-04-22 | E. R. Squibb & Sons, Inc. | Stable biotinylated biomolecule composition |
| US20030095890A1 (en) * | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
| US20030099743A1 (en) * | 2001-10-05 | 2003-05-29 | Brey Richard R. | Method of inhibiting sprouting in plant products |
| US20030162163A1 (en) * | 2001-12-21 | 2003-08-28 | Clearant, Inc. | Method of sterilizing heart valves |
| US20030161753A1 (en) * | 2001-03-23 | 2003-08-28 | Macphee Martin | Methods for sterilizing biological materials by multiple rates |
| US20030164285A1 (en) * | 2002-03-04 | 2003-09-04 | Steris Inc. | Mobile radiant energy sterilizer |
| US20030174810A1 (en) * | 2002-03-12 | 2003-09-18 | Steris Inc. | Method and apparatus for destroying microbial contamination of mail |
| US6623706B2 (en) | 2000-06-20 | 2003-09-23 | Advanced Electron Beams, Inc. | Air sterilizing system |
| US20030185702A1 (en) * | 2002-02-01 | 2003-10-02 | Wilson Burgess | Methods for sterilizing tissue |
| US6635222B2 (en) | 1993-07-22 | 2003-10-21 | Clearant, Inc. | Method of sterilizing products |
| US20040013562A1 (en) * | 2002-07-18 | 2004-01-22 | Wilson Burgess | Methods for sterilizing milk. |
| US20040033160A1 (en) * | 2002-07-18 | 2004-02-19 | Macphee Martin | Methods for sterilizing biological materials by irradiation over a temperature gradient |
| US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
| US20040067157A1 (en) * | 1993-07-22 | 2004-04-08 | Clearant, Inc. | Methods for sterilizing biological materials |
| US20040086420A1 (en) * | 2000-03-23 | 2004-05-06 | Macphee Martin J. | Methods for sterilizing serum or plasma |
| US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
| US6783968B2 (en) | 2001-09-24 | 2004-08-31 | Clearant, Inc. | Methods for sterilizing preparations of glycosidases |
| US6946098B2 (en) | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
| US20060076507A1 (en) * | 2000-06-20 | 2006-04-13 | Advanced Electron Beams, Inc. | Air Sterilizing system |
| US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| US20100112242A1 (en) * | 2006-10-26 | 2010-05-06 | Xyleco, Inc. | Processing biomass |
| US20110067830A1 (en) * | 2008-04-30 | 2011-03-24 | Xyleco, Inc | Functionalizing cellulosic and lignocellulosic materials |
| US20110124846A1 (en) * | 2008-04-30 | 2011-05-26 | Xyleco, Inc | Cellulosic and lignocellulosic structural materials and methods and systems for manufacturing such materials |
| US8198344B2 (en) | 2008-06-20 | 2012-06-12 | Adhezion Biomedical, Llc | Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator |
| US8293838B2 (en) | 2008-06-20 | 2012-10-23 | Adhezion Biomedical, Llc | Stable and sterile tissue adhesive composition with a controlled high viscosity |
| US8609128B2 (en) | 2008-10-31 | 2013-12-17 | Adhezion Biomedical, Llc | Cyanoacrylate-based liquid microbial sealant drape |
| US8613952B2 (en) | 2007-11-14 | 2013-12-24 | Adhezion Biomedical, Llc | Cyanoacrylate tissue adhesives |
| US8652510B2 (en) | 2008-10-31 | 2014-02-18 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
| US8729121B2 (en) | 2007-06-25 | 2014-05-20 | Adhezion Biomedical, Llc | Curing accelerator and method of making |
| US9018254B2 (en) | 2007-06-25 | 2015-04-28 | Adhezion Biomedical, Llc | Cyanoacrylate tissue adhesives with desirable permeability and tensile strength |
| US9254133B2 (en) | 2008-10-31 | 2016-02-09 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
| US9309019B2 (en) | 2010-05-21 | 2016-04-12 | Adhezion Biomedical, Llc | Low dose gamma sterilization of liquid adhesives |
| US9421297B2 (en) | 2014-04-02 | 2016-08-23 | Adhezion Biomedical, Llc | Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides |
| US9439809B2 (en) | 2010-03-26 | 2016-09-13 | 3M Innovative Properties Company | Method of sterilization of wound dressings |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2313599B2 (de) * | 1972-07-17 | 1977-07-14 | Imc Chemical Group Inc., Terre Haute, Ind. (V.St.A.) | Sterilisierung von bacitracin |
| DE3500487A1 (de) * | 1985-01-09 | 1986-07-10 | Hölter, Heinz, Dipl.-Ing., 4390 Gladbeck | Uv-ultraschallbesen zur entkeimung von flaechen und koerpern |
| DE3529310A1 (de) * | 1985-08-16 | 1987-03-05 | Hoelter Heinz | Verfahren zur reinigung von be- und entlueftungsschaechten in wohn- und krankenhaeusern, schulen, altenheimen usw. |
| EP1625859A1 (en) * | 2004-08-13 | 2006-02-15 | Access Group ApS | A process for the preparation of a package comprising a sterilised bulk of a substance, and a package comprising a sterilised bulk of a penicilin |
| FR3031903B1 (fr) * | 2015-01-28 | 2017-01-13 | Sidel Participations | Dispositif et procede de sterilisation de recipients en matiere thermoplastique au moyen d'un faisceau d'electrons pulse |
| RU2713275C1 (ru) * | 2019-08-20 | 2020-02-04 | Общество с ограниченной ответственностью "Победа-1" (ООО "Победа-1") | Способ производства сывороточного изолята для изготовления адаптированных молочных смесей и заменителей грудного молока |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2602751A (en) * | 1950-08-17 | 1952-07-08 | High Voltage Engineering Corp | Method for sterilizing substances or materials such as food and drugs |
| GB945801A (en) * | 1959-05-25 | 1964-01-08 | Merck & Co Inc | Sterilization of spores |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR973340A (fr) * | 1942-05-07 | 1951-02-09 | Procédé de stérilisation de substances et objets non alimentaires | |
| FR973339A (fr) * | 1942-05-07 | 1951-02-09 | Procédés de stérilisation et de stabilisation du sang entier humain et animal et de ses dérivés tels que le plasma sanguin, le sérum, les corpuscules lymphatiques et sanguins |
-
1971
- 1971-10-04 US US00186427A patent/US3779706A/en not_active Expired - Lifetime
-
1972
- 1972-07-25 SE SE7209695A patent/SE385539B/xx unknown
- 1972-07-25 GB GB3473072A patent/GB1361300A/en not_active Expired
- 1972-07-26 CA CA147,998A patent/CA963984A/en not_active Expired
- 1972-09-04 IT IT28793/72A patent/IT986850B/it active
- 1972-10-03 SU SU721834408A patent/SU603321A3/ru active
- 1972-10-03 FR FR7234967A patent/FR2155980B1/fr not_active Expired
- 1972-10-04 DE DE2249190A patent/DE2249190C3/de not_active Expired
- 1972-10-04 JP JP47099733A patent/JPS5235236B2/ja not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2602751A (en) * | 1950-08-17 | 1952-07-08 | High Voltage Engineering Corp | Method for sterilizing substances or materials such as food and drugs |
| GB945801A (en) * | 1959-05-25 | 1964-01-08 | Merck & Co Inc | Sterilization of spores |
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| US4439686A (en) * | 1980-09-16 | 1984-03-27 | Tetra Pak Developpement Ltd. | Electron beam-irradiating apparatus with conical bushing seal-support |
| US4620908A (en) * | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
| US5096553A (en) * | 1986-09-11 | 1992-03-17 | Ionizing Energy Company Of Canada Limited | Treatment of raw animal hides and skins |
| US6187572B1 (en) | 1990-04-16 | 2001-02-13 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
| US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5250257A (en) * | 1990-06-20 | 1993-10-05 | Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh | Process for the sterilization of implants |
| US5489783A (en) * | 1993-04-28 | 1996-02-06 | Tetra Laval Holdings & Finance S.A. | Electron accelerator for sterilizing packaging material in an aspetic packaging machine |
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| US6203755B1 (en) * | 1994-03-04 | 2001-03-20 | St. Jude Medical, Inc. | Electron beam sterilization of biological tissues |
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| US20030099743A1 (en) * | 2001-10-05 | 2003-05-29 | Brey Richard R. | Method of inhibiting sprouting in plant products |
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Also Published As
| Publication number | Publication date |
|---|---|
| FR2155980B1 (cs) | 1976-08-20 |
| JPS5235236B2 (cs) | 1977-09-08 |
| SU603321A3 (ru) | 1978-04-15 |
| SE385539B (sv) | 1976-07-12 |
| DE2249190B2 (de) | 1978-01-05 |
| IT986850B (it) | 1975-01-30 |
| GB1361300A (en) | 1974-07-24 |
| CA963984A (en) | 1975-03-04 |
| FR2155980A1 (cs) | 1973-05-25 |
| DE2249190C3 (de) | 1978-08-31 |
| DE2249190A1 (de) | 1973-04-12 |
| JPS4848263A (cs) | 1973-07-09 |
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