US3721525A - Process and device for sterilizing by flaming containers for pharmaceutical preparations - Google Patents

Process and device for sterilizing by flaming containers for pharmaceutical preparations Download PDF

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Publication number
US3721525A
US3721525A US00162974A US3721525DA US3721525A US 3721525 A US3721525 A US 3721525A US 00162974 A US00162974 A US 00162974A US 3721525D A US3721525D A US 3721525DA US 3721525 A US3721525 A US 3721525A
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US
United States
Prior art keywords
containers
sterilizing
flaming
current
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US00162974A
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English (en)
Inventor
H Hortig
K Schutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
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Hoechst AG
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Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
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Publication of US3721525A publication Critical patent/US3721525A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/06—Sterilising wrappers or receptacles prior to, or during, packaging by heat

Definitions

  • ABSTRACT 1 Containers for pharmaceuticals can be sterilized by 58.31 ..21/2, 2 "79,322: flaming, if the flames bum in a laminapflow current of I u 1 e v t t t I I s Q u u h l't k f A f 581 Field of Search ..21/2,79-, 78, 85,92, 93, 111, mammamn dev'ce 21/112, 117, 122', 263/19 A; 43l/D1G. 100, DIG. 106
  • flame-sterilizing such containers is fitted out with means to produce a laminar-flow air current through the sterilizing part of the device.
  • INVENTORS HANS-PETER Home KARL-FRIEDRICH SCHUTZ BY I v ATTORNEYS PROCESS AND DEVICE FOR STERILIZING BY FLAMING CONTAINERS FOR PHARMACEUTICAL PREPARATIONS
  • the present invention provides a process for sterilizing by flaming containers for pharmaceutical preparations, especially ampoules; it also provides a device to carry out the said process.
  • flaming constitutes a very economic process which was used in industry for a long while to sterilize containers, especially ampoules.
  • the containers were passed at a definite distance over flames, heated by the hot exhaust gas and thus'sterilized.
  • the aforesaid process had the disadvantages that the flames always formed soot, although a small quantity only, and additional foreign particles were introduced into the sterile zone by the gradual scaling of the burner. Hence, flaming was abandoned because of the modern requirement with respect to purity of the sterile zone not being met. Measurements have proved that the hot exhaust gas contained up to 2 X particles having a size greater than 0.5 micron per 3 liters.
  • containers for pharmaceutical preparations can be sterilized by flaming without danger of contamination by foreign particles by passing them through the current of exhaust gas over the tip of one or several flames burning in a laminar-flow current of air, said current having a velocity of flow in the range of from 0.05 to 0.3 meter per second.
  • the device according to the invention suitable to sterilize containers by flaming essentially consists of a burner, transporting means to transport the containers continuously or discontinuously over the burner and means to produce a purified air current through the sterilizing zone, and is characterized by a distributing device arranged at the air inlet into the sterilizing zone to cause the air to flow through the said zone in a laminar flow.
  • the distributing device may simultaneously act as filter for the air current. Sometimes, it may be more advantageous, however, to install the filter at another place.
  • a plate with holes or slits may be used as distributing device.
  • Blower l aspirates an air current through a preliminary filter 2 and conveys the said current throu h main filter 3 and air duct 4 to the sterilization cham er.
  • a distributing device 5 which transforms the arriving turbulent air current into a current with laminar flow 6.
  • Fuel gas is supplied through burner pipe 7.
  • Numeral 9 designates the transporting means, in the present case a turnable plate, the rim of which is provided with recesses wherein the ampoules 8 are suspended in a manner such that they pass by the tips of the flames of burner 7.
  • the hot exhaust air escapes at 10. An access to the sterilization chamber-if need should arise-is ensured by a flap l I.
  • the separate distributing device 5 may be dispensed with and its function may be taken over by main filter 3. With a separate distributing device it is more simple, however, to mount and exchange the main filter.
  • a process for sterilizing by flaming containers for pharmaceutical preparations which comprises passing the containers through the exhaust gas over the tip of one or several flames burning in a laminar-flow current of air, said current having a velocity of flow in the range of from 0.05 to 0.3 meter per second.
  • a device for carrying out the process of claim 1, comprising a sterilization chamber with burner and transporting means to transport the containers over the burner and means to produce a purified air current in the said sterilization chamber, wherein at the inlet of the air current into the sterilization chamber a distributing device is mounted to cause the air current to pass the sterilization zone in a laminar flow.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
US00162974A 1970-07-18 1971-07-15 Process and device for sterilizing by flaming containers for pharmaceutical preparations Expired - Lifetime US3721525A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2035822A DE2035822C3 (de) 1970-07-18 1970-07-18 Verfahren und Vorrichtung zum Sterilisieren von Behältern für pharmazeutische Präparate durch Abflammen

Publications (1)

Publication Number Publication Date
US3721525A true US3721525A (en) 1973-03-20

Family

ID=5777241

Family Applications (1)

Application Number Title Priority Date Filing Date
US00162974A Expired - Lifetime US3721525A (en) 1970-07-18 1971-07-15 Process and device for sterilizing by flaming containers for pharmaceutical preparations

Country Status (7)

Country Link
US (1) US3721525A (enExample)
JP (1) JPS5039957B1 (enExample)
DE (1) DE2035822C3 (enExample)
FR (1) FR2099453B1 (enExample)
GB (1) GB1345814A (enExample)
IT (1) IT992027B (enExample)
SE (1) SE361820B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3893807A (en) * 1973-11-30 1975-07-08 Univ Karlova Device for heating of instruments particularly for sterilization
US4921679A (en) * 1989-02-21 1990-05-01 Martin Juan N Exhaust system for laser surgery
US4923681A (en) * 1986-10-03 1990-05-08 Archeraire Industries, Inc. High velocity hot air sterilization device with controller
US20160090204A1 (en) * 2013-04-05 2016-03-31 G.F. S.P.A. Sterilising system

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5267148U (enExample) * 1975-11-13 1977-05-18
DE2631352C3 (de) * 1976-07-13 1983-02-17 Bayer Ag, 5090 Leverkusen Verfahren zur partikelarmen Sterilisation
DE3412597C2 (de) * 1984-04-04 1986-12-04 Gerresheimer Glas AG, 4000 Düsseldorf Vorrichtung zum Sterilisieren von Glasbehältern
DE102020114221A1 (de) * 2020-05-27 2021-12-02 Syntegon Technology Gmbh Vorrichtung und Verfahren zum schlagartigen Sterilisieren

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3893807A (en) * 1973-11-30 1975-07-08 Univ Karlova Device for heating of instruments particularly for sterilization
US4923681A (en) * 1986-10-03 1990-05-08 Archeraire Industries, Inc. High velocity hot air sterilization device with controller
US4921679A (en) * 1989-02-21 1990-05-01 Martin Juan N Exhaust system for laser surgery
US20160090204A1 (en) * 2013-04-05 2016-03-31 G.F. S.P.A. Sterilising system

Also Published As

Publication number Publication date
DE2035822C3 (de) 1978-04-06
DE2035822B2 (de) 1977-08-04
JPS5039957B1 (enExample) 1975-12-20
IT992027B (it) 1975-09-10
SE361820B (enExample) 1973-11-19
DE2035822A1 (de) 1972-01-27
GB1345814A (en) 1974-02-06
FR2099453B1 (enExample) 1976-02-13
FR2099453A1 (enExample) 1972-03-17

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