US3653380A - Aerosol powder dosage dispensing device - Google Patents

Aerosol powder dosage dispensing device Download PDF

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Publication number
US3653380A
US3653380A US11555A US3653380DA US3653380A US 3653380 A US3653380 A US 3653380A US 11555 A US11555 A US 11555A US 3653380D A US3653380D A US 3653380DA US 3653380 A US3653380 A US 3653380A
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United States
Prior art keywords
chamber
housing
gas
medicament
mouthpiece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US11555A
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English (en)
Inventor
Lloyd Frank Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
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Filing date
Publication date
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas

Definitions

  • a number of medicaments are introduced either orally or nasally.
  • nasal inhalators and there are also some devices for introducing finely divided medicament into the oral cavity and thence on into the respiratory system.
  • the nasal inhalator had a medicament chamber, openings to the atmosphere, and of course a projecting hollow member which was introduced into the nostril. On inhaling, air was sucked into the chamber, picked up medicament, which in some cases was liquid and other cases was sublimed from crystals.
  • the type of dispenser for introducing finely divided medicament into the oral cavity not only had a different shaped mouthpiece but usually had a container feeding into a venturi tube through which air or a gas flowed, picking up the medicament.
  • the present invention departs from prior designs in several important respects.
  • a medicament chamber into which gas or air under pressure is introduced at an angle to create turbulence so that all of the dosage introduced into the chamber is carried on into the human body cavity, e.g., nose or mouth, and thence on into the respiratory system.
  • a loose element such as a steel ball or, in another modification, half of the shell of a capsule carrying a dosage of medicament.
  • These movable elements vibrate, collide with the medicament being atomized, and prevent formation of or break up any coarser materials such as coarser aggregates of a powdered medicament. Also, adhering of medicament to the walls of the dispensing chamber is greatly reduced and for the most part completely eliminated.
  • the present invention therefore, ly divided spray of liquids of solid particles from an accurately predetermined dosage either into the nose or mouth or similar body cavity. No problem of over dosage is presented, which was a problem with the dispensers used in the past; and so even with medicaments which in excessive amounts have undesirable effects, complete safety is assured.
  • a chamber is formed with a plug and sealer and a funnelshaped entrance to a mouthpiece.
  • a conical screen is also provided further to assure that larger aggregates are not dispensed.
  • Gas under pressure is then introduced into the chamber substantially at right angles. High turbulence results, and if there is present a steel ball or other element which can vibrate and move, thorough and complete breaking up of aggregates results and the exactly predetermined dose is introduced in the best form.
  • the gas under pressure is introduced through two openings which direct a large volume of lower velocity gas directly into the chamber and a smaller volume of higher velocity gas into another part of the chamber to increase the turbulence.
  • the second general type of dispenser of the present invention at first glance appears somewhat similar to a nasal inhalator.
  • the air passages are sealed up and a tube or conduit carries gas under pressure into a side of the mixing chamber.
  • a tube or conduit carries gas under pressure into a side of the mixing chamber.
  • the gas comes in at an angle, there is high turbupermits discharging a finelence and a very thorough distribution of the medicament results.
  • the medicament is ordinarily introduced in a half of a capsule, the capsule half vibrating violently, which results in complete emptying of medicament dose and also breaks up larger aggregates.
  • the conduit enters at an angle which is not quite a right angle
  • the gas is usually introduced at right angles to the flow through the mouthpiece.
  • the particular angle is not critical so long as it is a sufficient angle to produce a high degree of turbulence. While it is theoretically possible to introduce liquids or suspensions in either type of dispenser, a liquid is much more readily introduced in the second type, so that the first type is primarily effective for medicament in the form of finely divided solids, although the invention is not strictly limited thereto and even in this type it is possible to introduce liquids although less readily than in the second type.
  • the nature of the gas under pressure actually forms no part of the present invention.
  • a volatile liquid or gas such as Freon
  • the dispenser when the dispenser is pressed onto the discharge valve of an aerosol can it should be pressed for a short but still sufficient time to assure that the full dosage of medicament in the dispensing chamber is ejected into the desired body cavity. This presents no problem as an exact time measurement is not needed.
  • FIGS. 1 to 5 relate to a dispenser for oral use.
  • the dispenser has a housing 1 forming 'part of a medicament chamber, with a mouthpiece 2 and a funnel-shaped inlet 3 to the mouthpiece in the housing 1.
  • a chamber is formed by a plug 5 with a conical end and a sealing O-ring 7.
  • a conical screen 4 which can be seen in the exploded view in FIG. 4 and in the assembled view in FIG. 5.
  • the chamber is assembled by first introducing the conical screen 4, which is slightly larger at its base than the internal diameter of the housing 1. This conical screen is introduced with its apex into the throat of the mouthpiece 2, as can be seen best in FIG. 5. A steel ball 6 is then introduced and the plug 5 inserted to a depth to produce a chamber of the desired dimensions. Chambers of various dimensions can be produced with the same equipment by varying the distance that the plug 5 is inserted into the housing 1. It will be seen that the dispensing chamber is between the conical end of the plug 5 and the screen 4.
  • a dose of medicament for example finely powdered medicament
  • the housing 1 being held so that the mouthpiece points up.
  • the finely divided medicament passes through the screen 4 and, if necessary, some tapping of the instrument may be used in order to be sure that all of the medicament enters the chamber.
  • an extension 8 on the housing 1 with a central conduit 9 is pushed onto the valve mechanism 10 of a conventional aerosol container, as is shown in FIG. 5.
  • This container is of somewhat simplified design as it is not required that it contain material to be sprayed.
  • Opening 12 is the larger one and opening 13 is the smaller one.
  • the steel ball 6 vibrates and bounces around, which assures further fineness of subdivision and also breaks up any larger aggregates of the powder so that everything is blown out through the screen 4 and the mouthpiece 2 and the whole of the predetermined dosage is introduced.
  • a single steel ball 6 is shown, but, of course, more than one may be present and they may be made of other materials.
  • FIGS. 6 and 7 show nasal inhalators.
  • the inhalator 14 with a hollow extension 15 which goes into the nostril, communicates with a medicament chamber 16.
  • the element 15 is screwed onto a boss on the inhalator 14 or can be a friction fit in the conventional manner.
  • This type of inhalator is very satisfactory where an accurately predetermined dose is not needed and can be used many times where materials such as sublimable anticongestants are present. However, exact predetermined dosage cannot be provided.
  • FIG. 7 shows the present invention, in which the openings 17 are completely eliminated and a tube 19, which at its other end attaches to the valve of the aerosol can enters into the chamber 16 at a right angle.
  • the nasal portion 15 is removed by unscrewing at 18, or removing it when it is a friction tit, and a half capsule 20 is introduced into the medicament chamber.
  • the inhalator element 15 is then fastened on by screwing or by friction fit and the tube 19 is brought into contact with the valve 10 of an aerosol can, as is shown for the other form of dispenser in FIG. 5.
  • the blast of Freon enters at an angle, causes high turbulence in the chamber 15, which is further advanced by the vibration and spinning of the half capsule 20, resulting in complete emptying thereof and in further turbulence, so that the whole dose is introduced into the nostril.
  • a dispenser for dispensing single doses of finely divided powdered medicament for oral use comprising a mouthpiece and an integral housing, a converging funnelshaped entrance in the housing leading to the mouthpiece,
  • pressure means for introducing gas into the chamber at an angle to the chamber
  • extension and housing is provided with a plurality of conduits to the medicament chamber, one of larger cross-section than the others, the conduits being positioned so that gas flowing through them produces streams which contact each other in the chamber.
  • a dispensing device in which one of the conduits is of greater cross-section than the other so that a larger volume of gas through the larger is struck by a smaller volume of gas through the smaller opening, thereby agitating said ball and inducing high turbulence, and both conduits are about tangential to the housing.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
US11555A 1970-02-16 1970-02-16 Aerosol powder dosage dispensing device Expired - Lifetime US3653380A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1155570A 1970-02-16 1970-02-16

Publications (1)

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US3653380A true US3653380A (en) 1972-04-04

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US11555A Expired - Lifetime US3653380A (en) 1970-02-16 1970-02-16 Aerosol powder dosage dispensing device

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US (1) US3653380A (enrdf_load_stackoverflow)
JP (1) JPS561102B1 (enrdf_load_stackoverflow)
AT (1) AT330951B (enrdf_load_stackoverflow)
BE (1) BE762948A (enrdf_load_stackoverflow)
CA (1) CA982005A (enrdf_load_stackoverflow)
CH (1) CH536119A (enrdf_load_stackoverflow)
DE (1) DE2106794C3 (enrdf_load_stackoverflow)
DK (1) DK132012C (enrdf_load_stackoverflow)
ES (1) ES194458Y (enrdf_load_stackoverflow)
FR (1) FR2078678A5 (enrdf_load_stackoverflow)
GB (1) GB1305172A (enrdf_load_stackoverflow)
HK (1) HK13176A (enrdf_load_stackoverflow)
MY (1) MY7600077A (enrdf_load_stackoverflow)
NL (1) NL164205C (enrdf_load_stackoverflow)
SE (1) SE381180B (enrdf_load_stackoverflow)
ZA (1) ZA717B (enrdf_load_stackoverflow)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998226A (en) * 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
US4046146A (en) * 1974-08-22 1977-09-06 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
AT375018B (de) * 1975-06-02 1984-06-25 Schering Ag Vorrichtung zur inhalation von arzneimitteln
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
US4706663A (en) * 1986-04-25 1987-11-17 Makiej Paul A Particle catcher for inhalation devices
US5379763A (en) * 1992-07-28 1995-01-10 Bespak Plc Dispensing apparatus for powdered medicaments
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
US5975076A (en) * 1993-12-31 1999-11-02 King's College London Dry powder inhalers
WO2001043802A1 (en) * 1999-12-17 2001-06-21 Inhale Therapeutic Systems, Inc. Systems and methods for treating packaged powders
WO2002056948A1 (en) * 2001-01-17 2002-07-25 Vectura Limited An inhaler device
US20030015191A1 (en) * 2001-04-26 2003-01-23 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2004110536A1 (en) * 2003-06-12 2004-12-23 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
WO2006059340A1 (en) * 2004-12-03 2006-06-08 Aparna Thirumalai Anandampilla A resonating (alerting) metered dose inhaler
WO2006075184A1 (en) * 2005-01-14 2006-07-20 Britannia Pharmaceuticals Limited Apparatus and methods for providing dry powder medicament for inhalation
US20080127971A1 (en) * 2004-09-13 2008-06-05 Michael King Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods
US20090125057A1 (en) * 2007-11-13 2009-05-14 Cordova Diana M Fan-Shaped Cannula For Sealing Ophthalmic Incisions
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
US20140209096A1 (en) * 2013-01-25 2014-07-31 Shaahin Cheyene Portable Inhaler
EP2653181A4 (en) * 2010-12-17 2014-08-27 Qingtang Chen PULVERARY MEDICINAL LAND AND ITS APPLICATION
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
WO2016160370A1 (en) * 2015-03-21 2016-10-06 Liu James Zhou Hand-actuated dry powder inhaler and its use
EP3024523A4 (en) * 2013-07-22 2017-03-22 Inhalation Sciences Sweden AB Apparatus and method for generating an aerosol
EP2433665A3 (de) * 2008-03-13 2018-02-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator und Sieb für einen Inhalator
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2019104192A1 (en) * 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface
US20210205548A1 (en) * 2020-01-06 2021-07-08 Boston Scientific Scimed, Inc. Agent delivery systems and methods of using the same

Families Citing this family (8)

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DE2502251A1 (de) * 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
LU86368A1 (fr) * 1986-03-24 1987-11-11 Oreal Procede pour preparer et distribuer un produit comprenant au moins deux composants,et dispositif pour sa mise en oeuvre
US5042472A (en) * 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
DE19600123A1 (de) * 1996-01-04 1997-07-10 Pfeiffer Erich Gmbh & Co Kg Austragkopf für Medien, insbesondere zur medikamentösen Behandlung des Rachens
DE19831525A1 (de) * 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
GB2353222B (en) * 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
GB2459257B (en) * 2008-04-14 2012-12-19 Alchemy Healthcare Ltd Particulate dispenser
DE102019219277A1 (de) * 2019-12-10 2021-06-10 Christian-Albrechts-Universität Zu Kiel Pulverförmige Formulierungen zur Inhalation

Citations (7)

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US960523A (en) * 1909-04-12 1910-06-07 Henri Edde Inhaler.
US1981623A (en) * 1933-07-18 1934-11-20 Harry B Karter Spraying device
US2533065A (en) * 1947-03-08 1950-12-05 George V Taplin Micropulverized therapeutic agents
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
US2556517A (en) * 1945-12-03 1951-06-12 Gaston L Broussard Nozzle for producing an intermittent jet of gas or liquid
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US3232493A (en) * 1964-03-10 1966-02-01 Risdon Mfg Co Pressurized dispensing package

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DE348622C (de) * 1922-02-13 Albrecht Meyenberg Dr Pulvergeblaese

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US960523A (en) * 1909-04-12 1910-06-07 Henri Edde Inhaler.
US1981623A (en) * 1933-07-18 1934-11-20 Harry B Karter Spraying device
US2556517A (en) * 1945-12-03 1951-06-12 Gaston L Broussard Nozzle for producing an intermittent jet of gas or liquid
US2533065A (en) * 1947-03-08 1950-12-05 George V Taplin Micropulverized therapeutic agents
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
US3232493A (en) * 1964-03-10 1966-02-01 Risdon Mfg Co Pressurized dispensing package

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046146A (en) * 1974-08-22 1977-09-06 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
AT375018B (de) * 1975-06-02 1984-06-25 Schering Ag Vorrichtung zur inhalation von arzneimitteln
US3998226A (en) * 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
US4706663A (en) * 1986-04-25 1987-11-17 Makiej Paul A Particle catcher for inhalation devices
US5379763A (en) * 1992-07-28 1995-01-10 Bespak Plc Dispensing apparatus for powdered medicaments
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
US5975076A (en) * 1993-12-31 1999-11-02 King's College London Dry powder inhalers
WO2001043802A1 (en) * 1999-12-17 2001-06-21 Inhale Therapeutic Systems, Inc. Systems and methods for treating packaged powders
EP1743670A3 (en) * 1999-12-17 2007-05-16 Nektar Therapeutics systems and methods for treating packaged powders
WO2002056948A1 (en) * 2001-01-17 2002-07-25 Vectura Limited An inhaler device
US20030015191A1 (en) * 2001-04-26 2003-01-23 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US7025058B2 (en) 2001-04-26 2006-04-11 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2004110536A1 (en) * 2003-06-12 2004-12-23 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
JP2006527046A (ja) * 2003-06-12 2006-11-30 ブリタニア ファーマシューティカルズ リミテッド 粉末エアロゾル用送給装置
AU2004246854B2 (en) * 2003-06-12 2010-02-18 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
US20070151560A1 (en) * 2003-06-12 2007-07-05 Robert Price Delivery device for a powder aerosol
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20060174869A1 (en) * 2004-02-24 2006-08-10 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US20100229860A1 (en) * 2004-02-24 2010-09-16 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US7318434B2 (en) * 2004-02-24 2008-01-15 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US7334577B2 (en) 2004-02-24 2008-02-26 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20080115784A1 (en) * 2004-02-24 2008-05-22 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US8322338B2 (en) 2004-02-24 2012-12-04 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US9027551B2 (en) 2004-09-13 2015-05-12 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US20080127971A1 (en) * 2004-09-13 2008-06-05 Michael King Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods
US8365725B2 (en) * 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
WO2006059340A1 (en) * 2004-12-03 2006-06-08 Aparna Thirumalai Anandampilla A resonating (alerting) metered dose inhaler
GB2437464A (en) * 2004-12-03 2007-10-24 Thirumalai Anandampilla Aparna A resonating (alerting) metered dose inhaler
WO2006075184A1 (en) * 2005-01-14 2006-07-20 Britannia Pharmaceuticals Limited Apparatus and methods for providing dry powder medicament for inhalation
US8790366B2 (en) * 2007-11-13 2014-07-29 Alcon Research, Ltd. Fan-shaped cannula for sealing ophthalmic incisions
US20090125057A1 (en) * 2007-11-13 2009-05-14 Cordova Diana M Fan-Shaped Cannula For Sealing Ophthalmic Incisions
EP2433665A3 (de) * 2008-03-13 2018-02-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator und Sieb für einen Inhalator
US8763606B2 (en) 2009-05-21 2014-07-01 Microdose Therapeutx, Inc. Rotary cassette system for dry powder inhaler
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
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Also Published As

Publication number Publication date
CH536119A (de) 1973-04-30
CA982005A (en) 1976-01-20
ZA717B (en) 1971-10-27
DE2106794A1 (de) 1971-08-26
NL7101065A (enrdf_load_stackoverflow) 1971-08-18
DK132012B (da) 1975-10-13
MY7600077A (en) 1976-12-31
ES194458Y (es) 1975-04-01
BE762948A (fr) 1971-08-16
ES194458U (es) 1974-02-16
AT330951B (de) 1976-07-26
SE381180B (sv) 1975-12-01
DE2106794C3 (de) 1982-04-08
NL164205C (nl) 1980-12-15
GB1305172A (enrdf_load_stackoverflow) 1973-01-31
NL164205B (nl) 1980-07-15
ATA128471A (de) 1975-10-15
DK132012C (da) 1976-03-08
FR2078678A5 (enrdf_load_stackoverflow) 1971-11-05
JPS561102B1 (enrdf_load_stackoverflow) 1981-01-12
DE2106794B2 (de) 1981-06-25
HK13176A (en) 1976-03-19

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