US3653380A - Aerosol powder dosage dispensing device - Google Patents

Aerosol powder dosage dispensing device Download PDF

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US3653380A
US3653380A US3653380DA US3653380A US 3653380 A US3653380 A US 3653380A US 3653380D A US3653380D A US 3653380DA US 3653380 A US3653380 A US 3653380A
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chamber
housing
gas
medicament
mouthpiece
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Lloyd Frank Hansen
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0005Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8218Gas operated
    • A61M2205/8225Gas operated using incorporated gas cartridges for the driving gas

Abstract

A dispensing device is described with a mixing chamber in which a dose of powder or other medicament is introduced through an outlet for a human body cavity, such as a mouthpiece or a hollow projection suitable for inserting in a nostril. A source of gas under pressure, for example from an aerosol can, is introduced into the chamber at an angle, and there is present in the chamber a larger movable element, such as a steel ball, which vibrates and breaks up the particles or aggregates. In one modification a half capsule containing the dosage may be introduced into the chamber and the capsule after emptying itself constitutes the moving element.

Description

arisen [54] AEROSOL POWDER DOSAGE 1,981,623 11/1934 Karter ..239/142 x DISPENSING DEVICE 2,642,063 6/1953 Brown ..l28/206 3,232,493 2 1966 B d, J ..128 265 UX [72] Inventor: Lloyd Frank Hansen, Campbell Hall, N.Y. ear I [73] Assignee: American Cyanamid Company, Stamford, Primary Examiner-Rihard Gaudet Conn. Assistant Examiner.l. C. McGowan 2] Filed: Feb. 1970 Attorney-Norton S. Johnson [21] App]. No.: 11,555 [57] ABSTRACT A dispensing device is described with a mixing chamber in [52] US. Cl ..128/266, 128/203, 128/206 which a dose of powder or other medicament is introduced [51] int. Cl. ..A6lm 13/00, A6lm 11/00, A611 13/00 through an outlet for a human body cavity, such as a Field of Search mouthpiece or a hollow projection suitable for inserting in a 239/1421 307; 222/193 nostril. A source of gas under pressure, for example from an aerosol can, is introduced into the chamber at an angle, and [56] References cued there is present in the chamber a larger movable element, such UNITED STATES PATENTS I as a steel ball, which vibrates and breaks up the particles or aggregates. In one modificatlon a half capsule contalnmg the Brollssard 5 dosage may be introduced into the chamber and the capsule 2,533,065 12/1950 Taplm after emptying itself constitutes the moving element.

960,523 6/1910 Edde 2,534,636 12/1950 Stirn ..l28/266 X 2 Claims, 7 Drawing Figures Patented Aprfl 4, 1972 2 Sheets-$heot l MOU THP/ECE INVENI'OR.

LLOYD FRANK HANSEN AT TOR/V5 Y I AEROSOL POWDER DOSAGE DISPENSING DEVICE BACKGROUND OF THE INVENTION A number of medicaments are introduced either orally or nasally. For instance, there are a number of nasal inhalators and there are also some devices for introducing finely divided medicament into the oral cavity and thence on into the respiratory system. In the past there were two general types. The nasal inhalator had a medicament chamber, openings to the atmosphere, and of course a projecting hollow member which was introduced into the nostril. On inhaling, air was sucked into the chamber, picked up medicament, which in some cases was liquid and other cases was sublimed from crystals. The type of dispenser for introducing finely divided medicament into the oral cavity not only had a different shaped mouthpiece but usually had a container feeding into a venturi tube through which air or a gas flowed, picking up the medicament.

Where there was no reason to measure the dose accurately, these types of dispensers were quite satisfactory and are used on a large scale, particularly the nasal inhalators. However, for many purposes it is desireable to introduce a definitely measured dose, and this was difficult or impossible with the devices which were used in the past. It is with improved dispensing devices which can dispense accurately measured doses that the present invention deals.

SUMMARY OF THE INVENTION The present invention departs from prior designs in several important respects. First, there is a medicament chamber into which gas or air under pressure is introduced at an angle to create turbulence so that all of the dosage introduced into the chamber is carried on into the human body cavity, e.g., nose or mouth, and thence on into the respiratory system.

Another important feature of the present invention is that in the medicament chamber there is present a loose element, such as a steel ball or, in another modification, half of the shell of a capsule carrying a dosage of medicament. These movable elements vibrate, collide with the medicament being atomized, and prevent formation of or break up any coarser materials such as coarser aggregates of a powdered medicament. Also, adhering of medicament to the walls of the dispensing chamber is greatly reduced and for the most part completely eliminated.

The present invention, therefore, ly divided spray of liquids of solid particles from an accurately predetermined dosage either into the nose or mouth or similar body cavity. No problem of over dosage is presented, which was a problem with the dispensers used in the past; and so even with medicaments which in excessive amounts have undesirable effects, complete safety is assured.

In general, the principles of the present invention can be incorporated into two somewhat different shaped devices. In one device, which is particularly usable with finely divided solid medicaments for oral use, a chamber is formed with a plug and sealer and a funnelshaped entrance to a mouthpiece. Preferably a conical screen is also provided further to assure that larger aggregates are not dispensed. Gas under pressure is then introduced into the chamber substantially at right angles. High turbulence results, and if there is present a steel ball or other element which can vibrate and move, thorough and complete breaking up of aggregates results and the exactly predetermined dose is introduced in the best form. In a preferred modification of this type of dispenser, the gas under pressure is introduced through two openings which direct a large volume of lower velocity gas directly into the chamber and a smaller volume of higher velocity gas into another part of the chamber to increase the turbulence.

The second general type of dispenser of the present invention at first glance appears somewhat similar to a nasal inhalator. However, the air passages are sealed up and a tube or conduit carries gas under pressure into a side of the mixing chamber. As the gas comes in at an angle, there is high turbupermits discharging a finelence and a very thorough distribution of the medicament results. The medicament is ordinarily introduced in a half of a capsule, the capsule half vibrating violently, which results in complete emptying of medicament dose and also breaks up larger aggregates.

In the second type of dispenser referred to above, ordinarily the conduit enters at an angle which is not quite a right angle, whereas in the first type described above the gas is usually introduced at right angles to the flow through the mouthpiece. The particular angle is not critical so long as it is a sufficient angle to produce a high degree of turbulence. While it is theoretically possible to introduce liquids or suspensions in either type of dispenser, a liquid is much more readily introduced in the second type, so that the first type is primarily effective for medicament in the form of finely divided solids, although the invention is not strictly limited thereto and even in this type it is possible to introduce liquids although less readily than in the second type.

Reference has been made to introducing the medicament into the respiratory system. This is the most important field for the present invention, but it is possible to introduce small doses of medicament into the nasal passages in the second type of dispenser without their being driven into the lungs. Also, while the nose and mouth are the cavities in which the dispensers of the present invention are primarily used, other bodily cavities can also receive accurately predetermined dosages of finely divided medicament; and therefore, in its broader aspects the present invention is not strictly limited to dispensers to be used in oral or nasal use.

The nature of the gas under pressure actually forms no part of the present invention. However, it is desirable to form the gas introducing tube to the mixing chamber so that it can be pressed on the discharge valve of an ordinary aerosol container which contains a volatile liquid or gas, such as Freon, of suitable boiling point. This permits a very compact and readily portable package and may be considered as the preferred form of use of the invention. It should be understood that when the dispenser is pressed onto the discharge valve of an aerosol can it should be pressed for a short but still sufficient time to assure that the full dosage of medicament in the dispensing chamber is ejected into the desired body cavity. This presents no problem as an exact time measurement is not needed.

BRIEF DESCRIPTION OF THE DRAWINGS through a nasal inhalator of DESCRIPTION OF THE PREFERRED EMBODIMENTS FIGS. 1 to 5 relate to a dispenser for oral use. The dispenser has a housing 1 forming 'part of a medicament chamber, with a mouthpiece 2 and a funnel-shaped inlet 3 to the mouthpiece in the housing 1. A chamber is formed by a plug 5 with a conical end and a sealing O-ring 7. There is also provided a conical screen 4, which can be seen in the exploded view in FIG. 4 and in the assembled view in FIG. 5.

The chamber is assembled by first introducing the conical screen 4, which is slightly larger at its base than the internal diameter of the housing 1. This conical screen is introduced with its apex into the throat of the mouthpiece 2, as can be seen best in FIG. 5. A steel ball 6 is then introduced and the plug 5 inserted to a depth to produce a chamber of the desired dimensions. Chambers of various dimensions can be produced with the same equipment by varying the distance that the plug 5 is inserted into the housing 1. It will be seen that the dispensing chamber is between the conical end of the plug 5 and the screen 4.

In use a dose of medicament, for example finely powdered medicament, is introduced through the mouthpiece, the housing 1 being held so that the mouthpiece points up. The finely divided medicament passes through the screen 4 and, if necessary, some tapping of the instrument may be used in order to be sure that all of the medicament enters the chamber. Then an extension 8 on the housing 1 with a central conduit 9 is pushed onto the valve mechanism 10 of a conventional aerosol container, as is shown in FIG. 5. This container is of somewhat simplified design as it is not required that it contain material to be sprayed.

When pressed down on the valve, the Freon gas in the container flows into the chamber through two openings, which can be seen in the cross-section view of FIG. 1. Opening 12 is the larger one and opening 13 is the smaller one. Most of the Freon enters through the larger opening 12 and because of the size of the opening has relatively low velocity. A smaller portion at much higher velocity enters through the opening 13 and the two streams of gas strike each other and further enhance the turbulence. The steel ball 6 vibrates and bounces around, which assures further fineness of subdivision and also breaks up any larger aggregates of the powder so that everything is blown out through the screen 4 and the mouthpiece 2 and the whole of the predetermined dosage is introduced. A single steel ball 6 is shown, but, of course, more than one may be present and they may be made of other materials.

FIGS. 6 and 7 show nasal inhalators. In FIG. 6 the inhalator 14, with a hollow extension 15 which goes into the nostril, communicates with a medicament chamber 16. The element 15 is screwed onto a boss on the inhalator 14 or can be a friction fit in the conventional manner. When the inhalator is introduced into a nostril and the patient inhales, air flows in through the tubes 17 and a portion of the medicament in the chamber 16 is introduced into the nostril. This type of inhalator is very satisfactory where an accurately predetermined dose is not needed and can be used many times where materials such as sublimable anticongestants are present. However, exact predetermined dosage cannot be provided.

FIG. 7 shows the present invention, in which the openings 17 are completely eliminated and a tube 19, which at its other end attaches to the valve of the aerosol can enters into the chamber 16 at a right angle. In use the nasal portion 15 is removed by unscrewing at 18, or removing it when it is a friction tit, and a half capsule 20 is introduced into the medicament chamber. The inhalator element 15 is then fastened on by screwing or by friction fit and the tube 19 is brought into contact with the valve 10 of an aerosol can, as is shown for the other form of dispenser in FIG. 5. The blast of Freon enters at an angle, causes high turbulence in the chamber 15, which is further advanced by the vibration and spinning of the half capsule 20, resulting in complete emptying thereof and in further turbulence, so that the whole dose is introduced into the nostril.

While in the type shown in FIGS. 1 to 5 it is usually preferable to introduce the exact dosage through the mouthpiece, it is, of course, possible to remove the plug 5 and introduce a half capsule as in FIG. 7 into the chamber, replacing the plug and proceeding then as has been described above in connection with FIGS. 1 to 5.

I claim:

1. A dispenser for dispensing single doses of finely divided powdered medicament for oral use, comprising a mouthpiece and an integral housing, a converging funnelshaped entrance in the housing leading to the mouthpiece,

a conical screen element fitting into said entrance,

a plug with a conical end introducible into the housing from the end opposite the mouthpiece and provided with sealing means, whereby a medicament chamber of predetermined size 15 formed by introducing the plug a predetermined distance into said housing,

at least one movable ball in the medicament chamber,

which ball vibrates or spins when gas pressure is introduced, whereby turbulence results,

pressure means for introducing gas into the chamber at an angle to the chamber,

and an extension on the housing at right angles to the mouthpiece axis and shaped to receive gas from said pressure means, which extension and housing is provided with a plurality of conduits to the medicament chamber, one of larger cross-section than the others, the conduits being positioned so that gas flowing through them produces streams which contact each other in the chamber.

2. A dispensing device according to claim 1 in which one of the conduits is of greater cross-section than the other so that a larger volume of gas through the larger is struck by a smaller volume of gas through the smaller opening, thereby agitating said ball and inducing high turbulence, and both conduits are about tangential to the housing.

Claims (2)

1. A dispenser for dispensing single doses of finely divided powdered medicament for oral use, comprising a mouthpiece and an integral housing, a converging funnel-shaped entrance in the housing leading to the mouthpiece, a conical screen element fitting into said entrance, a plug with a conical end introducible into the housing from the end opposite the mouthpiece and provided with sealing means, whereby a medicament chamber of predetermined size is formed by introducing the plug a predetermined distance into said housing, at least one movable ball in the medicament chamber, which ball vibrates or spins when gas pressure is introduced, whereby turbulence results, pressure means for introducing gas into the chamber at an angle to the chamber, and an extension on the housing at right angles to the mouthpiece axis and shaped to receive gas from said pressure means, which extension and housing is provided with a plurality of conduits to the medicament chamber, one of larger crosssection than the others, the conduits being positioned so that gas flowing through them produces streams which contact each other in the chamber.
2. A dispensing device according to claim 1 in which one of the conduits is of greater cross-section than the other so that a larger volume of gas through the larger is struck by a smaller volume of gas through the smaller opening, thereby agitating said ball and inducing high turbulence, and both conduits are about tangential to the housing.
US3653380D 1970-02-16 1970-02-16 Aerosol powder dosage dispensing device Expired - Lifetime US3653380A (en)

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998226A (en) * 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
US4046146A (en) * 1974-08-22 1977-09-06 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
AT375018B (en) * 1975-06-02 1984-06-25 Schering Ag Device for inhalation of drugs
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
US4706663A (en) * 1986-04-25 1987-11-17 Makiej Paul A Particle catcher for inhalation devices
US5379763A (en) * 1992-07-28 1995-01-10 Bespak Plc Dispensing apparatus for powdered medicaments
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
US5975076A (en) * 1993-12-31 1999-11-02 King's College London Dry powder inhalers
WO2001043802A1 (en) * 1999-12-17 2001-06-21 Inhale Therapeutic Systems, Inc. Systems and methods for treating packaged powders
WO2002056948A1 (en) * 2001-01-17 2002-07-25 Vectura Limited An inhaler device
US20030015191A1 (en) * 2001-04-26 2003-01-23 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2004110536A1 (en) * 2003-06-12 2004-12-23 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
WO2006059340A1 (en) * 2004-12-03 2006-06-08 Aparna Thirumalai Anandampilla A resonating (alerting) metered dose inhaler
WO2006075184A1 (en) * 2005-01-14 2006-07-20 Britannia Pharmaceuticals Limited Apparatus and methods for providing dry powder medicament for inhalation
US20080127971A1 (en) * 2004-09-13 2008-06-05 Michael King Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods
US20090125057A1 (en) * 2007-11-13 2009-05-14 Cordova Diana M Fan-Shaped Cannula For Sealing Ophthalmic Incisions
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
EP2653181A1 (en) * 2010-12-17 2013-10-23 Qingtang Chen Powder medicament mouthpiece and application
US20140209096A1 (en) * 2013-01-25 2014-07-31 Shaahin Cheyene Portable Inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
WO2016160370A1 (en) * 2015-03-21 2016-10-06 Liu James Zhou Hand-actuated dry powder inhaler and its use
EP3024523A4 (en) * 2013-07-22 2017-03-22 Inhalation Sciences Sweden AB Apparatus and method for generating an aerosol
EP2433665A3 (en) * 2008-03-13 2018-02-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhaler and sieve for an inhaler
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2019104192A1 (en) * 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2502251A1 (en) * 1975-01-17 1976-07-22 Schering Ag Device for inhalation pulverfoermiger solids
LU86368A1 (en) * 1986-03-24 1987-11-11 Oreal A method for preparing and dispensing a product comprising at least two components, and device for its implementation
US5042472A (en) * 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
DE19600123A1 (en) * 1996-01-04 1997-07-10 Pfeiffer Erich Gmbh & Co Kg Discharge head for media, in particular for the medical treatment of the throat
DE19831525A1 (en) * 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Dispenser for media
GB2353222B (en) * 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
GB2459257B (en) * 2008-04-14 2012-12-19 Alchemy Healthcare Ltd Particulate dispenser

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US960523A (en) * 1909-04-12 1910-06-07 Henri Edde Inhaler.
US1981623A (en) * 1933-07-18 1934-11-20 Harry B Karter Spraying device
US2533065A (en) * 1947-03-08 1950-12-05 George V Taplin Micropulverized therapeutic agents
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
US2556517A (en) * 1945-12-03 1951-06-12 Gaston L Broussard Nozzle for producing an intermittent jet of gas or liquid
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US3232493A (en) * 1964-03-10 1966-02-01 Risdon Mfg Co Pressurized dispensing package

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE348622C (en) * 1922-02-13 Albrecht Meyenberg Dr Pulvergeblaese

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US960523A (en) * 1909-04-12 1910-06-07 Henri Edde Inhaler.
US1981623A (en) * 1933-07-18 1934-11-20 Harry B Karter Spraying device
US2556517A (en) * 1945-12-03 1951-06-12 Gaston L Broussard Nozzle for producing an intermittent jet of gas or liquid
US2533065A (en) * 1947-03-08 1950-12-05 George V Taplin Micropulverized therapeutic agents
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
US3232493A (en) * 1964-03-10 1966-02-01 Risdon Mfg Co Pressurized dispensing package

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046146A (en) * 1974-08-22 1977-09-06 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
AT375018B (en) * 1975-06-02 1984-06-25 Schering Ag Device for inhalation of drugs
US3998226A (en) * 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
US4534345A (en) * 1981-07-08 1985-08-13 Aktiebolaget Draco Dosage inhalator
US4706663A (en) * 1986-04-25 1987-11-17 Makiej Paul A Particle catcher for inhalation devices
US5379763A (en) * 1992-07-28 1995-01-10 Bespak Plc Dispensing apparatus for powdered medicaments
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
US5975076A (en) * 1993-12-31 1999-11-02 King's College London Dry powder inhalers
WO2001043802A1 (en) * 1999-12-17 2001-06-21 Inhale Therapeutic Systems, Inc. Systems and methods for treating packaged powders
EP1743670A3 (en) * 1999-12-17 2007-05-16 Nektar Therapeutics systems and methods for treating packaged powders
WO2002056948A1 (en) * 2001-01-17 2002-07-25 Vectura Limited An inhaler device
US20030015191A1 (en) * 2001-04-26 2003-01-23 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US7025058B2 (en) 2001-04-26 2006-04-11 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2004110536A1 (en) * 2003-06-12 2004-12-23 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
AU2004246854B2 (en) * 2003-06-12 2010-02-18 Britannia Pharmaceuticals Limited Delivery device for a powder aerosol
US20070151560A1 (en) * 2003-06-12 2007-07-05 Robert Price Delivery device for a powder aerosol
JP2006527046A (en) * 2003-06-12 2006-11-30 ブリタニア ファーマシューティカルズ リミテッド Feeder for powder aerosol
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20060174869A1 (en) * 2004-02-24 2006-08-10 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US20100229860A1 (en) * 2004-02-24 2010-09-16 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US8322338B2 (en) 2004-02-24 2012-12-04 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US7318434B2 (en) * 2004-02-24 2008-01-15 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US7334577B2 (en) 2004-02-24 2008-02-26 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20080115784A1 (en) * 2004-02-24 2008-05-22 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US8365725B2 (en) * 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US9027551B2 (en) 2004-09-13 2015-05-12 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US20080127971A1 (en) * 2004-09-13 2008-06-05 Michael King Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods
WO2006059340A1 (en) * 2004-12-03 2006-06-08 Aparna Thirumalai Anandampilla A resonating (alerting) metered dose inhaler
GB2437464A (en) * 2004-12-03 2007-10-24 Thirumalai Anandampilla Aparna A resonating (alerting) metered dose inhaler
WO2006075184A1 (en) * 2005-01-14 2006-07-20 Britannia Pharmaceuticals Limited Apparatus and methods for providing dry powder medicament for inhalation
US8790366B2 (en) * 2007-11-13 2014-07-29 Alcon Research, Ltd. Fan-shaped cannula for sealing ophthalmic incisions
US20090125057A1 (en) * 2007-11-13 2009-05-14 Cordova Diana M Fan-Shaped Cannula For Sealing Ophthalmic Incisions
EP2433665A3 (en) * 2008-03-13 2018-02-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhaler and sieve for an inhaler
US8763606B2 (en) 2009-05-21 2014-07-01 Microdose Therapeutx, Inc. Rotary cassette system for dry powder inhaler
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
EP2653181A1 (en) * 2010-12-17 2013-10-23 Qingtang Chen Powder medicament mouthpiece and application
EP2653181A4 (en) * 2010-12-17 2014-08-27 Qingtang Chen Powder medicament mouthpiece and application
US20140209096A1 (en) * 2013-01-25 2014-07-31 Shaahin Cheyene Portable Inhaler
EP3024523A4 (en) * 2013-07-22 2017-03-22 Inhalation Sciences Sweden AB Apparatus and method for generating an aerosol
WO2016160370A1 (en) * 2015-03-21 2016-10-06 Liu James Zhou Hand-actuated dry powder inhaler and its use
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2019104192A1 (en) * 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface

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DE2106794B2 (en) 1981-06-25
CA982005A1 (en)
SE381180B (en) 1975-12-01
BE762948A1 (en)
CH536119A (en) 1973-04-30
NL164205B (en) 1980-07-15
DK132012C (en) 1976-03-08
CA982005A (en) 1976-01-20
BE762948A (en) 1971-08-16
MY7600077A (en) 1976-12-31
JPS561102B1 (en) 1981-01-12
DE2106794C3 (en) 1982-04-08
HK13176A (en) 1976-03-19
GB1305172A (en) 1973-01-31
DE2106794A1 (en) 1971-08-26
FR2078678A5 (en) 1971-11-05
ATA128471A (en) 1975-10-15
ZA7100007B (en) 1971-10-27
NL164205C (en) 1980-12-15
ES194458Y (en) 1975-04-01
DK132012B (en) 1975-10-13
ES194458U (en) 1974-02-16
NL7101065A (en) 1971-08-18
AT330951B (en) 1976-07-26

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