US3578291A - Test tube having integral mixing means - Google Patents

Test tube having integral mixing means Download PDF

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Publication number
US3578291A
US3578291A US861251A US3578291DA US3578291A US 3578291 A US3578291 A US 3578291A US 861251 A US861251 A US 861251A US 3578291D A US3578291D A US 3578291DA US 3578291 A US3578291 A US 3578291A
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US
United States
Prior art keywords
test tube
longitudinal axis
sidewall
stirring
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US861251A
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English (en)
Inventor
Rudolf Oberli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Greiner Electronic AG
Original Assignee
Greiner Electronic AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greiner Electronic AG filed Critical Greiner Electronic AG
Application granted granted Critical
Publication of US3578291A publication Critical patent/US3578291A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions

Definitions

  • Laubscher ABSTRACT A test tube for mixing liquids, characterized by the provision of integral stirring means extending longitudifially from the bottom wall in spaced relation to the sidewall of the tube.
  • the stirring means preferably is of knifelike configuration including a longitudinal edge adjacent and spaced from the internal surface of the sidewall whereby upon oscillation of the test tube about its longitudinal axis, a vortex is formed adjacent the edge to effect rapid thorough mixing.
  • the test tube has a capacity of between about 0.5 and 5 milliliters and is designed for disposal after a single use.
  • test tubes which usually have a capacity of between approximately 0.5 and milliliters.
  • the test tubes themselves are intended generally to be used only once, and must therefore be relatively inexpensive.
  • the present invention relates to a test tube having a capacity within the milliliter range which is designed preferably for being used only once and consists of an essentially cylindrical tube having an integral bottom wall.
  • at least one integral knifelike stirring means is disposed coaxially within the test tube of the present invention, which stirring means extend radially outwardly from the longitudinal axis of the tube to define a gap between its outer pointed extremity and the inner surface of the test tube wall.
  • the stirring means are integral with the bottom of the test tube and extend upwardly in spaced relation to the test tube sidewall.
  • the stirring means has a double-knife configuration including a pair of pointed portions that extend diametrically radially outwardly from the longitudinal axis of the test tube.
  • the inner wall surface of the tube is smooth throughout, whereas the outer extremities of the pointed projections are provided with sharp edges that extend longitudinally adjacent and spaced from the wall surface.
  • the sidewall surfaces of the stirring means are also smooth.
  • FIG. 1 is a longitudinal cross section view of the improved mixing test tubule of the present invention.
  • FIG. 2 is a sectional view taken along line 2-2 of FIG. 1, illustrating diagrammatically the means for supporting and oscillating the test tube.
  • the test tube according to FlGS. 1 and 2 is made preferably of an inexpensive impervious material, such as polypropylene for example, and includes a tubular sidewall portion 3 and an integral bottom wall portion 4.
  • the upper surface of the bottom wall is planar and is arranged at a right angle with respect to the longitudinal axis 5.
  • double knife edge stirring means including symmetrical pointed portions 6, 6 that extend diametrically radially outwardly from the longitudinal axis 5 and terminate in longitudinal edges 7, 7' that are adjacent and spaced form the inner wall.
  • the stirring means is integral with and extends upwardly from the bottom wall 4 in concentrically spaced relation to the tubular wall 3.
  • the inner wall surface of the tube 3, the upper surface of the bottom 4 and the lateral surfaces of the stirring means 6, 6 all have completely smooth surfaces.
  • the tube 3 is provided with guide pins 9 and 9' and 10, 10 that project laterally outwardly from the tube for reception in the tube holder means that are driven by conventional oscillatory drive means as shown in FIG. 2.
  • the test tube illustrated in the drawing is intended for a capacity within the milliliter range, the height of the tube 3 being on the order of 5.0 centimeters, for a tube having an inside diameter of approximately l.3 centimeters.
  • test tube is axially inserted or slid downwardly into the supporting means within which it is held securely against torsion by means of the guide pins 9, 9 and 10, 10.
  • the holder is oscillated about its longitudinal axis 5 by the oscillatory drive means. ln the case of a test tube having the dimensions set forth above, it has been found advantageous to employ an amplitude of the rotary oscillations of approximately :40 radians if the frequency of the rotary oscillations is between 5 and 10 cycles per second.
  • test tube When a liquid to be mixed is inserted into the test tube and sinusoidal rotational oscillations are imparted to the tube, considerable relative velocities of the liquid with respect to the tubular wall are temporarily produced in the gaps 8 and 8'. A vigorous vortex formation is produced adjacent the sharp edges 7 and 7 which, in turn, brings about a rapid and thorough stim'ng or intermixture of the liquid. It is a particular advantage of the present invention that there will be no formation of bubbles and no spilling of the liquid.
  • the test tube may therefore be filled to a point near the upper rounded-off portion of the tongues'6 and 6' (FIG. 1).
  • the desired stirring or intimate mixing effect will be produced also if the test tubule is filled only for a very small fraction of the tubular height thereof.
  • test tube adapted for mixing a liquid and including integral bottom 4 and tubular sidewall 3'portions defining a cavity within the milliliter range
  • said test tube includes at least one stirring portion 6, 6' arranged in coaxially spaced relation within said tubular portion and integrally connected at one end with said bottom portion, said stirring portion having a knifelike configuration including in transverse cross section at least one radially outwardly extending pointed portion defining a longitudinal edge 7, 7 adjacent and spaced form the inner wall surface of said tubular portion, whereby when said test tube is oscillated about its longitudinal axis, a vortex is formed in the gap 8, 8' adjacent the edge to effect rapid mixing of the liquid in the test tube.
  • test tube as defined in claim 1, wherein the inner surface of said cylindrical sidewall portion is smooth.
  • test tube as defined in claim 1, wherein the surface carried by said bottom wall defining the bottom of said cavity is planar and arranged at right angles to the longitudinal axis of said test tube.
  • Apparatus defined in clairn 6 wherein the length and the internal diameter of the tubular sidewall portion are about 5.0 centimeters and 1.3 centimeters, respectively.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US861251A 1969-01-22 1969-09-26 Test tube having integral mixing means Expired - Lifetime US3578291A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH87669A CH475793A (de) 1969-01-22 1969-01-22 Proberöhrchen

Publications (1)

Publication Number Publication Date
US3578291A true US3578291A (en) 1971-05-11

Family

ID=4197225

Family Applications (1)

Application Number Title Priority Date Filing Date
US861251A Expired - Lifetime US3578291A (en) 1969-01-22 1969-09-26 Test tube having integral mixing means

Country Status (7)

Country Link
US (1) US3578291A (enrdf_load_stackoverflow)
JP (1) JPS4941588B1 (enrdf_load_stackoverflow)
CH (1) CH475793A (enrdf_load_stackoverflow)
DE (2) DE1932368C3 (enrdf_load_stackoverflow)
FR (1) FR2028835A1 (enrdf_load_stackoverflow)
GB (1) GB1272828A (enrdf_load_stackoverflow)
SE (1) SE345207B (enrdf_load_stackoverflow)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549574A (en) * 1994-08-30 1996-08-27 Eli Lilly And Company Cartridge assembly for use in a pen-type medicament injector
US5609822A (en) * 1995-07-07 1997-03-11 Ciba Corning Diagnostics Corp. Reagent handling system and reagent pack for use therein
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) * 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
EP0770207A4 (en) * 1994-07-12 1999-10-13 Brian S Bull QUICK DETERMINATION OF BLOOD REDUCTION SPEED
US6063340A (en) * 1991-03-04 2000-05-16 Chiron Diagnostics Corporation Reagent container for automated analyzer
US6066300A (en) * 1995-07-07 2000-05-23 Bayer Corporation Reagent handling system and configurable vial carrier for use therein
US6436349B1 (en) * 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
US6498037B1 (en) * 1991-03-04 2002-12-24 Bayer Corporation Method of handling reagents in a random access protocol
US20060013729A1 (en) * 1991-02-14 2006-01-19 Glen Carey Fluid handling apparatus for an automated analyzer
US20080192567A1 (en) * 2007-02-08 2008-08-14 Kathleen Vincent Reagent cartridge mixing tube
US20090311775A1 (en) * 2005-12-22 2009-12-17 Sartorius Stedim Biotech Gmbh Disposable Bioreactor for Culturing Cells in a Nutrient Medium
CN113049758A (zh) * 2021-04-07 2021-06-29 浙江衡谱医药有限公司 一种具有对比功能的药物中间体研发用检测装置

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0330085Y2 (enrdf_load_stackoverflow) * 1985-09-06 1991-06-26
DE4419971A1 (de) * 1994-06-08 1995-12-14 Eppendorf Geraetebau Netheler Gefäß zum Temperieren kleiner Flüssigkeitsmengen in einem Thermostaten

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1298832A (en) * 1914-03-12 1919-04-01 James J Tracy Apparatus for dyeing and the like.
GB757061A (en) * 1953-09-26 1956-09-12 Bosch Gmbh Robert Improvements in or relating to washing machines
US2965274A (en) * 1958-08-13 1960-12-20 Michael N Brillis Paper coffee cup
US3432149A (en) * 1966-04-27 1969-03-11 Nils Gustav Stalberg Apparatus for stirring a liquid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1298832A (en) * 1914-03-12 1919-04-01 James J Tracy Apparatus for dyeing and the like.
GB757061A (en) * 1953-09-26 1956-09-12 Bosch Gmbh Robert Improvements in or relating to washing machines
US2965274A (en) * 1958-08-13 1960-12-20 Michael N Brillis Paper coffee cup
US3432149A (en) * 1966-04-27 1969-03-11 Nils Gustav Stalberg Apparatus for stirring a liquid

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060013729A1 (en) * 1991-02-14 2006-01-19 Glen Carey Fluid handling apparatus for an automated analyzer
US6063340A (en) * 1991-03-04 2000-05-16 Chiron Diagnostics Corporation Reagent container for automated analyzer
US7182912B2 (en) 1991-03-04 2007-02-27 Bayer Corporation Fluid handling apparatus for an automated analyzer
US20050266570A1 (en) * 1991-03-04 2005-12-01 Bayer Corporation Cuvette for an automated analyzer
US6074615A (en) * 1991-03-04 2000-06-13 Bayer Corporation Reagent container for an automated analyzer
US6436349B1 (en) * 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
US6498037B1 (en) * 1991-03-04 2002-12-24 Bayer Corporation Method of handling reagents in a random access protocol
US6555062B1 (en) 1991-03-04 2003-04-29 Bayer Corporation Reagent container for an automated analyzer
EP0770207A4 (en) * 1994-07-12 1999-10-13 Brian S Bull QUICK DETERMINATION OF BLOOD REDUCTION SPEED
US5549574A (en) * 1994-08-30 1996-08-27 Eli Lilly And Company Cartridge assembly for use in a pen-type medicament injector
US5788928A (en) * 1995-07-07 1998-08-04 Chiron Diagnostics Corporation Reagent handling system and reagent pack for use therein
US5609822A (en) * 1995-07-07 1997-03-11 Ciba Corning Diagnostics Corp. Reagent handling system and reagent pack for use therein
US6066300A (en) * 1995-07-07 2000-05-23 Bayer Corporation Reagent handling system and configurable vial carrier for use therein
US6562298B1 (en) 1996-09-19 2003-05-13 Abbott Laboratories Structure for determination of item of interest in a sample
US5856194A (en) * 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US20090311775A1 (en) * 2005-12-22 2009-12-17 Sartorius Stedim Biotech Gmbh Disposable Bioreactor for Culturing Cells in a Nutrient Medium
US9174181B2 (en) 2005-12-22 2015-11-03 Sartorius Stedim Biotech Gmbh Disposable bioreactor for culturing cells in a nutrient medium
US20080192567A1 (en) * 2007-02-08 2008-08-14 Kathleen Vincent Reagent cartridge mixing tube
US7731414B2 (en) * 2007-02-08 2010-06-08 Instrumentation Laboratory Company Reagent cartridge mixing tube
US20100187253A1 (en) * 2007-02-08 2010-07-29 Kathleen Vincent Reagent cartridge mixing tube
US8550697B2 (en) 2007-02-08 2013-10-08 Biokit, S.A. Reagent cartridge mixing tube
US9636647B2 (en) 2007-02-08 2017-05-02 Biokit, S.A. Reagent cartridge mixing tube method
CN113049758A (zh) * 2021-04-07 2021-06-29 浙江衡谱医药有限公司 一种具有对比功能的药物中间体研发用检测装置

Also Published As

Publication number Publication date
GB1272828A (en) 1972-05-03
DE1932368B2 (de) 1978-06-29
CH475793A (de) 1969-07-31
DE7000617U (de) 1970-09-17
SE345207B (enrdf_load_stackoverflow) 1972-05-23
DE1932368C3 (de) 1979-02-22
JPS4941588B1 (enrdf_load_stackoverflow) 1974-11-09
DE1932368A1 (de) 1970-07-30
FR2028835A1 (enrdf_load_stackoverflow) 1970-10-16

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