US3562820A - Tubular sheet and strip form prostheses on a basis of biological tissue - Google Patents
Tubular sheet and strip form prostheses on a basis of biological tissue Download PDFInfo
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- US3562820A US3562820A US661900A US3562820DA US3562820A US 3562820 A US3562820 A US 3562820A US 661900 A US661900 A US 661900A US 3562820D A US3562820D A US 3562820DA US 3562820 A US3562820 A US 3562820A
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- tissue
- prostheses
- prosthesis
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- biological tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1348—Cellular material derived from plant or animal source [e.g., wood, cotton, wool, leather, etc.]
Definitions
- the prosthesis itself comprises a unitary structure of alternating layers of natural tissue and collagen fibres.
- the same is manufactured by applying a strip, sheet or tube of biological material onto a substantially rigid support, coating the exposed surface with a binder paste, as for example, a collagen fibre paste, or bringing about the swelling of the exposed surface, thereafter applying a second layer of natural material and repeating the procedure until the desired Wall thickness is obtained.
- the multi-layer prosthesis is then dried and removed from the underlying support.
- the invention described herein relates to tubular, strip and sheet form prostheses on a basis of biological tissue and to methods for manufacturing and using the same. More particularly this invention relates to a multi-layer prosthesis on a basis of biological tissue.
- the prostheses of the invention are suitable for use as vascular, esophagus, bronchus, intestinal, ureter and cardiac valve prostheses and as other corrective parts of various organs such as liver.
- the present invention overcomes the difficulties above mentioned and provides a prosthetic device for use in the replacement, repair and strengthening of living organs superior in effectiveness to anything previously known.
- One of the objects of the invention is the provision of a prosthesis that is created from biological tissue which does not undergo deterioration after installation even after prolonged periods.
- Another object is the provision of a prosthesis that is created from biological tissue that will allow for and facilitate tissue growth and organ regeneration at the site of installation.
- a further object is the provision of a prosthesis that is created from biological tissue which can be simply and effectively installed using the conventional techniques.
- Still a further object of the invention is the provision of a method by which such a prosthesis on a basis of biological tissue can be formed.
- FIG. 1 is a longitudinal central section through an embodiment of a prosthesis in accordance with the invention
- FIG. 2 is a diagrammatic view illustrating the method of forming the prosthesis of FIG. 1;
- FIGS. 3 and 4 are diagrammatic perspective views illustrating two somewhat different forms of the prostheses embodying the invention.
- a prosthesis in tubular, sheet or strip form which comprises at least two layers of biological tissue intimately joined and dried. More specific-ally the prosthesis comprises alternating layers of biological tissue and collagen fibers intimately joined and dried.
- the biological prostheses are manufactured by placing over, i.e., applying onto the surface of a firm support a piece of tubular, sheet or strip form biological tissue, causing the exposed surface thereof to swell so as to produce thereon an adhesive or glue like effect and/ or the exposed surface is coated with a binder or bonding agent as for example a collagen fiber paste, a second piece of biological tissue is then applied to the first and the procedure repeated until a multi-layered structure of the desired wall thickness is obtained. The prosthesis is then dried and removed from the support.
- a binder or bonding agent as for example a collagen fiber paste
- the submucosa As natural tissue for use in the manufacture of the prostheses of the invention there are suitable in particular the submucosa, which can be obtained in pure form from the small intestine of sheep, goats and other animals, and the so-called goldbeaters skin, which is made up of the serosa taken from the intestines of cattle.
- the submucosa which is obtained in the form of a fine, but high strength tube, is composed of diagonally disposed collagen fibres.
- the mucosa and muscular tissue still adhering to the submucosa can easily be removed by the process as conventionally used in the manufacture of catgut.
- the collagen fibre paste may be prepared, for example, by the process described in German patent specification No. 659,490. Furthermore, this layer of collagen fibres ensures that any holes, tears, and the like made in the tissue during the manufacture thereof, during the operation for installing the same, or a later time, will close easily. This can prevent hemorrhage, which hitherto has been highly dangerous.
- the collagen fibre paste has a further advantage in that therapeutic substances may be incorporated therein. Thus, for example, heparin may be added to inhibit the clotting of blood, cartilage powder or chondroitin sulfate included to stimulate the formation of new collagen fibres for the vascular intima, as Well as other therapeutic substances.
- a tubular core or a plate made of glass or a synthetic material as the firm, more or less rigid support.
- synthetic materials include polyolefins as for example polyethylene or polypropylene etc.
- any inert fairly firm material may be employed.
- a lubricant as for example, glycerol or a silicone oil.
- the tissue is then coated with a binder paste, preferably a collagen fibre paste, and, if necessary, the paste is allowed to dry slightly. Another piece of tissue is then applied, and the process is repeated until the desired thickness is obtained.
- the finished prosthesis may contain, for example, about eight layers of tissue. The number of layers is generally determined by the thickness of the composite layers and by the ultimate use.
- the prosthesis made by the process of the invention may be subjected to a hardening process to prevent premature absorption by the body tissues.
- hardening agents there may be used physiologically acceptable vegetable or synthetic substances or, as for example, aldehydes. Instances of aldehydes that are suitable for this purpose are formaldehyde, glutardialdehyde and aldehydes of higher polyhydroxy compounds. The concentration of the hardening agent may be varied to produce the rate of absorption required.
- fascia prostheses are obtained which are generally known as patches and which may be used to close defects in the tympanic membrane and the heart wall, for hollow-walled organs or as heart valves.
- collagen patches in sheet form are also used to repair damage to parenchymatous soft tissue, for example, in the liver, kidney, spleen and pancreas. This can be effected in the following manner:
- a so-called mattress suture is made, i.e., a large atrau matic needle threaded with a soft suture is passed through the parenchymatous tissue on one side of the wound and out of the other side.
- the needle is then passed through a stiffened and perforated collagen patch from underneath.
- the needle is then passed back through an adjacent perforation in the collagen patch at an appropriate distance from the point at which it emerged, through the organ and out the other side.
- the length of the suture should be such that a second perforated collagen patch may be threaded onto the two ends. When the needle has been removed, the two ends of the suture are knotted together over the collagen patch.
- Strips for surgical purposes may also be cut from sheets, i.e., membranes of the same material.
- Tubular, flat or fluted prostheses may also be made by the process of the invention in addition to membranes and strips.
- the tubular prostheses may be of uniform diameter throughout their length or their diameter may be widened or narrowed conically.
- a tube made of synthetic material as, for example, a tube made of polyethylene or polypropylene and which has been provided with a plurality of threads 2 is thoroughly cleaned and, if necessary, treated with a silicone oil.
- the submucosa 3 is thus provided with a thread 2' and is of a standardized size.
- tissue is then coated with a binder paste, preferably a collagen fibre paste, the paste is allowed to dry slightly, and then another tube of tissue is drawn over the first one.
- a synthetic filament is wound round it as before and the tissue is dried. This procedure may be repeated until the desired thickness of wall is obtained.
- the multiple layers of tissue are firmly cemented together by the binder.
- the threaded tube of tissue so obtained has the necessary strength, density and elasticity required of vascular prostheses, and it can be sutured and is puncture-proof.
- the thread with which it is provided prevents it from kinking when it is moved after implantation in the host, thereby permitting an unhindered flow of blood. It is also extensible.
- a smooth tubular prosthesis that is to say, without any thread or fluting, for example, as used for prosthetic repair of the cystic duct, the ureter, the esophagus or, in special cases, blood vessels
- the same procedure as with the screw-threaded plastic tube may be followed, but without winding a filament round the tissue or allowing it to conform to the shape of the thread.
- the elastic tube of tissue is drawn over the plastic tube and held taut over it by tying the tissue tube at both ends and allowing it to conform to the outer circumference of the plastic tube without complementing the shape of the thread.
- a smooth plastic tube may be used as a support, for the layers of tissue.
- Prostheses for example, for the esophagus, trachea and intestine, can be made by the process described above, with due regard to anatomical requirements, diameter and thickness of wall.
- the strength of such prostheses can be considerably increased by placing layers of synthetic or natural tissue or even metallic clasps or spirals between the layers making up the actual prosthesis.
- the synthetic tissue used may be made, for example, from polyamide or polyester fibres.
- the natural tissue may be, for example, biological tissue, for exam ple, serosa tissue, or material made from natural fibres.
- the serosa tissue may be wound round the prosthesis diagonally, first from left to right and then from right to left. If necessary, these layers of tissue may be pretreated, as for example, by stretching.
- the process has a negative effect on the physical properties of the collagen fibre and neutralization is generally necessary afterwards, followed by washing out of the salts formed during neutralization.
- Sterilization of the prostheses so obtained may be elfected by gamma-radiation, which process also reduces the antigenic properties of the collagen.
- FIGS. 3 and 4 there are shown two somewhat ditferent forms of the prostheses in accordance with the invention.
- FIG. 3 the embodiment comprising alternating layers of biological tissue 7 bonded together with a bond ing agent 8 is shown and in FIG. 4 the embodiment wherein the bonding is effected by swelling the layers 7 is set out.
- the prostheses in accordance with the invention has been subjected to trial and has been observed and evaluated as a suitability, production of toxic symptoms, decomposition, detachment, secondary reactions such as abnormal tissue growth, etc.
- the trials consisted in surgical implantation of the prostheses in otherwise normal animals, i.e., the requirement for the prostheses was surgically induced, observation of the thusly treated animals during the recovery period and for varying periods thereafter. During this time, numerous test procedures were carried out, the same including chemical, X-ray, electrocardiographic, etc., procedures. At the end of various predetermined time intervals certain of the animals were sacrificed and any of the animals possibly involved organs examined both microscopically and macroscopically. In every instance, the results of procedures and tests in both the living and sacrificed animals established the safety and suitability of the prosthetic devices for replacement and repair of damaged organs. It is to be noted that as experimental animals, there were employed cats, dogs and monkeys.
- the device has been surgically implanted in human subjects, in each case where the subjects condition was indicative of such treatment. Almost all of the subjects are still under observation and to date there have not been observed any untoward results or happenings directly associated with the use of the herein disclosed prosthetic devices.
- a tubular prosthetic device on a basis of biological tissue comprising at least two superimposed layers consisting of tubes of natural tissue applied in their natural tubular form prepared from the submucous layers of intestines of mammals, and said layers being bonded together by means of collagen fibers.
- a prosthetic device according to claim 1 wherein said collagen fibres consist of a collagen fiber paste.
- a prosthetic device according to claim 1 wherein at least one of said layers is a prehardened layer which has been prehardened by contacting the same with a hardening agent.
- a prosthetic device according to claim 3 wherein said hardening agent is an aldehyde.
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Abstract
There are disclosed tubular, sheet and strip form prostheses on a basis of biological tissue for use in the replacement, repair and strengthening of various living organs such as the vasculature, esophagus, bronchus, intesting, ureter, liver, kidney, etc. and a process for making and using the same. The prosthesis itself comprises a unitary structure of alternating layers of natural tissue and collagen fibers. The same is manufactured by applying a strip, sheet or tube of biological material onto a substantially rigid support, coatings the exposed surface with a binder paste, as for example, a collagen fibre paste, or bringing about the swelling of the exposed surface, thereafter applying a second layer of natural material and repeating the procedure until the desired wall thickness is obtained. The multi-layer prosthesis is then dried and removed from underlying support.
Description
Feb. 16, 1971 BRUN TUBULAR SHEET AND STRIP FORM PROSTHESES ON A BASIS OF BIOLOGICAL TISSUE Filed Aug. 21, 1967 WIIIIIIIIIIIIIIII FIG. 2
INVENTOR BERNHARD BRAUN Maf pl? ATTORNEYS.
United States Patent 3,562,820 TUBULAR SHEET AND STRIP FORM PROSTHESES ON A BASIS OF BIOLOGICAL TISSUE Bernhard Braun, Trankeiucke 1, Melsungen, Germany Filed Aug. 21, 1967, Ser. No. 661,900 Claims priority, application Austria, Aug. 22, 1966, A 7,958/66 Int. Cl. A61f 1/24 US. Cl. 3-1 5 Claims ABSTRACT OF THE DISCLOSURE There are disclosed tubular, sheet and strip form prostheses on a basis of biological tissue for use in the replacement, repair and strengthening of various living organs such as the vasculature, esophagus, bronchus, intestine, ureter, liver, kidney, etc. and a process for making and using the same. The prosthesis itself comprises a unitary structure of alternating layers of natural tissue and collagen fibres. The same is manufactured by applying a strip, sheet or tube of biological material onto a substantially rigid support, coating the exposed surface with a binder paste, as for example, a collagen fibre paste, or bringing about the swelling of the exposed surface, thereafter applying a second layer of natural material and repeating the procedure until the desired Wall thickness is obtained. The multi-layer prosthesis is then dried and removed from the underlying support.
The invention described herein relates to tubular, strip and sheet form prostheses on a basis of biological tissue and to methods for manufacturing and using the same. More particularly this invention relates to a multi-layer prosthesis on a basis of biological tissue.
The prostheses of the invention are suitable for use as vascular, esophagus, bronchus, intestinal, ureter and cardiac valve prostheses and as other corrective parts of various organs such as liver.
It is already known to prepare tubes and fabrics from polytetrafluoroethylene or polyester fibers, either by weaving or knitting or by a combined weaving and knitting process and to use the same to replace diseased blood vessels or parts of the heart. At first, clinical results with these prostheses were satisfactory and highly promising, but deterioration set in after some considerable time (Materia Medica Nordmark 16, [1964], page 245 and Der Internist 6 [1965] H. 5, page 216). Among the other disadvantages which were observed, for example, was that natural tissue did not grow into the synthetic fibre fabric. To overcome this disadvantage it has been proposed to make the synthetic fibre fabrics in a more open mesh, but this impaired other properties of the prostheses, for example, the strength thereof. A further disadvantage associated with the known synthetic fibre prostheses is the difliculty encountered in suturing the same into position because the synthetic fiber prostheses tear easily and the holes thus formed do not close.
The present invention overcomes the difficulties above mentioned and provides a prosthetic device for use in the replacement, repair and strengthening of living organs superior in effectiveness to anything previously known.
One of the objects of the invention is the provision of a prosthesis that is created from biological tissue which does not undergo deterioration after installation even after prolonged periods.
Another object is the provision of a prosthesis that is created from biological tissue that will allow for and facilitate tissue growth and organ regeneration at the site of installation.
Patented Feb. 16, 1971 A further object is the provision of a prosthesis that is created from biological tissue which can be simply and effectively installed using the conventional techniques.
Still a further object of the invention is the provision of a method by which such a prosthesis on a basis of biological tissue can be formed.
The manner in which these and other objects of this invention are obtained will become apparent from the detailed description and the following drawings in which:
FIG. 1 is a longitudinal central section through an embodiment of a prosthesis in accordance with the invention;
FIG. 2 is a diagrammatic view illustrating the method of forming the prosthesis of FIG. 1; and
FIGS. 3 and 4 are diagrammatic perspective views illustrating two somewhat different forms of the prostheses embodying the invention.
According to the invention there is provided a prosthesis in tubular, sheet or strip form which comprises at least two layers of biological tissue intimately joined and dried. More specific-ally the prosthesis comprises alternating layers of biological tissue and collagen fibers intimately joined and dried.
According to the present invention, the biological prostheses are manufactured by placing over, i.e., applying onto the surface of a firm support a piece of tubular, sheet or strip form biological tissue, causing the exposed surface thereof to swell so as to produce thereon an adhesive or glue like effect and/ or the exposed surface is coated with a binder or bonding agent as for example a collagen fiber paste, a second piece of biological tissue is then applied to the first and the procedure repeated until a multi-layered structure of the desired wall thickness is obtained. The prosthesis is then dried and removed from the support.
As natural tissue for use in the manufacture of the prostheses of the invention there are suitable in particular the submucosa, which can be obtained in pure form from the small intestine of sheep, goats and other animals, and the so-called goldbeaters skin, which is made up of the serosa taken from the intestines of cattle. The submucosa, which is obtained in the form of a fine, but high strength tube, is composed of diagonally disposed collagen fibres. The mucosa and muscular tissue still adhering to the submucosa can easily be removed by the process as conventionally used in the manufacture of catgut.
As the strength of a single layer of submucoca is far too inadequate, the same having a thickness of only about 15 1,, it is advantageous to use a number of layers cemented together with a binder, as for example, a collagen fibre paste. The collagen fibre paste may be prepared, for example, by the process described in German patent specification No. 659,490. Furthermore, this layer of collagen fibres ensures that any holes, tears, and the like made in the tissue during the manufacture thereof, during the operation for installing the same, or a later time, will close easily. This can prevent hemorrhage, which hitherto has been highly dangerous. The collagen fibre paste has a further advantage in that therapeutic substances may be incorporated therein. Thus, for example, heparin may be added to inhibit the clotting of blood, cartilage powder or chondroitin sulfate included to stimulate the formation of new collagen fibres for the vascular intima, as Well as other therapeutic substances.
It is also possible to cause the individual layers of tissue to swell and to bond them together in the swollen state. Organic acids, especially dilute lactic acid, have been found to be particularly suitable for swelling the single layers. The use of highly dilute solutions of lactic acid is preferred in this connection as the same has the advantage that no acidic end products are formed.
In carrying out the process of the invention it is possible to use, for example, a tubular core or a plate made of glass or a synthetic material as the firm, more or less rigid support. Instances of synthetic materials include polyolefins as for example polyethylene or polypropylene etc. However, any inert fairly firm material may be employed. Prior to use, it is advantageous to treat the surface or surfaces of the support with a lubricant, as for example, glycerol or a silicone oil. A thoroughly cleansed tubular or flat piece of biological tissue, for example, submucosa or serosa tissue, which may have been subjected to bleaching with hydrogen peroxide, is then placed onto the support. The tissue is then coated with a binder paste, preferably a collagen fibre paste, and, if necessary, the paste is allowed to dry slightly. Another piece of tissue is then applied, and the process is repeated until the desired thickness is obtained. The finished prosthesis may contain, for example, about eight layers of tissue. The number of layers is generally determined by the thickness of the composite layers and by the ultimate use.
The prosthesis made by the process of the invention may be subjected to a hardening process to prevent premature absorption by the body tissues. As hardening agents there may be used physiologically acceptable vegetable or synthetic substances or, as for example, aldehydes. Instances of aldehydes that are suitable for this purpose are formaldehyde, glutardialdehyde and aldehydes of higher polyhydroxy compounds. The concentration of the hardening agent may be varied to produce the rate of absorption required.
The hardening process is preferably carried out after the final layer of tissue has been applied. However, it is possible to harden the single layers of tissue before they are applied. By adopting this latter procedure, the single layers of tissue may be hardened to varying degrees, thereby producing a prosthesis in which the single layers have different rates of absorption. For example, when using a tubular core as a support, the innermost layers may be hardened to a considerable degree to produce a tough, resistant core, and the outside layers may be only slightly hardened to ensure a specific rate of absorption.
After removal of the support and, if necessary, after the tube has been cut open, fascia prostheses are obtained which are generally known as patches and which may be used to close defects in the tympanic membrane and the heart wall, for hollow-walled organs or as heart valves.
Furthermore, collagen patches in sheet form are also used to repair damage to parenchymatous soft tissue, for example, in the liver, kidney, spleen and pancreas. This can be effected in the following manner:
A so-called mattress suture is made, i.e., a large atrau matic needle threaded with a soft suture is passed through the parenchymatous tissue on one side of the wound and out of the other side. The needle is then passed through a stiffened and perforated collagen patch from underneath. The needle is then passed back through an adjacent perforation in the collagen patch at an appropriate distance from the point at which it emerged, through the organ and out the other side. The length of the suture should be such that a second perforated collagen patch may be threaded onto the two ends. When the needle has been removed, the two ends of the suture are knotted together over the collagen patch.
Strips for surgical purposes, as for example, for securing a movable kidney or for use in surgery of the incontinentia vesicae, may also be cut from sheets, i.e., membranes of the same material.
Tubular, flat or fluted prostheses may also be made by the process of the invention in addition to membranes and strips. The tubular prostheses may be of uniform diameter throughout their length or their diameter may be widened or narrowed conically.
Referring to the drawing a tube made of synthetic material as, for example, a tube made of polyethylene or polypropylene and which has been provided with a plurality of threads 2 is thoroughly cleaned and, if necessary, treated with a silicone oil. A tube of tissue 3, preferably submucosa, which has been thoroughly cleansed and, if necessary, bleached With hydrogen peroxide, is drawn over the polyethylene tube 1, allowed to dry slightly, if necessary, and then a synthetic filament 4 is wound round the tubular tissue corresponding to the depressions of the thread and the tissue is dried. The filament may then be removed. The submucosa 3 is thus provided with a thread 2' and is of a standardized size. The tissue is then coated with a binder paste, preferably a collagen fibre paste, the paste is allowed to dry slightly, and then another tube of tissue is drawn over the first one. A synthetic filament is wound round it as before and the tissue is dried. This procedure may be repeated until the desired thickness of wall is obtained. The multiple layers of tissue are firmly cemented together by the binder. When the single layers of tissue are to be united by swelling it is possible either first to swell the single layers of tissue and to draw them onto the tube or core in the swollen state or to swell them on the core. To free the tube formed by these layers of tissue from the supporting tube or core, warm air is passed through the tube or core in this case a plastic tube, to soften it slightly, whereupon both ends of the tube are pulled until it stretches and detaches from the tissue at the beginning of the thread section. It can then be pulled out of the submucosa tube in the form of a plastic filament without the submucosa tube adhering to it or being damaged. Prostheses suitable for various purposes may be produced by varying the pitch of the thread, the depth of the thread and the number of turns.
The threaded tube of tissue so obtained has the necessary strength, density and elasticity required of vascular prostheses, and it can be sutured and is puncture-proof. The thread with which it is provided prevents it from kinking when it is moved after implantation in the host, thereby permitting an unhindered flow of blood. It is also extensible.
On the other hand, if a smooth tubular prosthesis is required, that is to say, without any thread or fluting, for example, as used for prosthetic repair of the cystic duct, the ureter, the esophagus or, in special cases, blood vessels, the same procedure as with the screw-threaded plastic tube may be followed, but without winding a filament round the tissue or allowing it to conform to the shape of the thread. The elastic tube of tissue is drawn over the plastic tube and held taut over it by tying the tissue tube at both ends and allowing it to conform to the outer circumference of the plastic tube without complementing the shape of the thread. Alternatively, a smooth plastic tube may be used as a support, for the layers of tissue.
Prostheses, for example, for the esophagus, trachea and intestine, can be made by the process described above, with due regard to anatomical requirements, diameter and thickness of wall. The strength of such prostheses can be considerably increased by placing layers of synthetic or natural tissue or even metallic clasps or spirals between the layers making up the actual prosthesis. The synthetic tissue used may be made, for example, from polyamide or polyester fibres. The natural tissue may be, for example, biological tissue, for exam ple, serosa tissue, or material made from natural fibres. The serosa tissue may be wound round the prosthesis diagonally, first from left to right and then from right to left. If necessary, these layers of tissue may be pretreated, as for example, by stretching.
It is also possible to bond the layers of tissue by swelling the tubular or flat pieces in an acidic or alkaline medium. In this process the upper layers of collagen fibers are slightly hydrolyzed and converted into tropocollagen which, on drying, has a glue-like adhesive effect.
The process has a negative effect on the physical properties of the collagen fibre and neutralization is generally necessary afterwards, followed by washing out of the salts formed during neutralization.
Sterilization of the prostheses so obtained may be elfected by gamma-radiation, which process also reduces the antigenic properties of the collagen.
In FIGS. 3 and 4 there are shown two somewhat ditferent forms of the prostheses in accordance with the invention. In FIG. 3 the embodiment comprising alternating layers of biological tissue 7 bonded together with a bond ing agent 8 is shown and in FIG. 4 the embodiment wherein the bonding is effected by swelling the layers 7 is set out.
The prostheses in accordance with the invention has been subjected to trial and has been observed and evaluated as a suitability, production of toxic symptoms, decomposition, detachment, secondary reactions such as abnormal tissue growth, etc. The trials consisted in surgical implantation of the prostheses in otherwise normal animals, i.e., the requirement for the prostheses was surgically induced, observation of the thusly treated animals during the recovery period and for varying periods thereafter. During this time, numerous test procedures were carried out, the same including chemical, X-ray, electrocardiographic, etc., procedures. At the end of various predetermined time intervals certain of the animals were sacrificed and any of the animals possibly involved organs examined both microscopically and macroscopically. In every instance, the results of procedures and tests in both the living and sacrificed animals established the safety and suitability of the prosthetic devices for replacement and repair of damaged organs. It is to be noted that as experimental animals, there were employed cats, dogs and monkeys.
The device has been surgically implanted in human subjects, in each case where the subjects condition was indicative of such treatment. Almost all of the subjects are still under observation and to date there have not been observed any untoward results or happenings directly associated with the use of the herein disclosed prosthetic devices.
What is claimed is:
1. A tubular prosthetic device on a basis of biological tissue comprising at least two superimposed layers consisting of tubes of natural tissue applied in their natural tubular form prepared from the submucous layers of intestines of mammals, and said layers being bonded together by means of collagen fibers.
2. A prosthetic device according to claim 1 wherein said collagen fibres consist of a collagen fiber paste.
3. A prosthetic device according to claim 1 wherein at least one of said layers is a prehardened layer which has been prehardened by contacting the same with a hardening agent.
4. A prosthetic device according to claim 3 wherein said hardening agent is an aldehyde.
5. A hardened prosthetic device according to claim 1 wherein said prosthetic device has been hardened by treatment thereof with a hardening agent.
References Cited UNITED STATES PATENTS 1,254,031 l/1918 Davis 128-3355 2,127,903 8/1938 Bowen 128334 3,272,204 9/1966 Artandi et a1. 128-334 3,366,440 1/1968 Nuwayser 128-334X 3,425,418 2/ 1969 Chvapil et al 128334 OTHER REFERENCES Experimental and Clinical Utilization of a Prosthesis for Replacement of the Trachea, by R. E. Taber et al., A.M.A. Archives of Surgery, vol. 77, October 1958, pp. 576-583. I
DALTON L. TRULUCK, Primary Examiner R. L. FRINKS, Assistant Examiner US. Cl. X.R.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT795866A AT261800B (en) | 1966-08-22 | 1966-08-22 | Process for the manufacture of tubular, smooth or threaded tissue-blood vessel prostheses |
Publications (1)
Publication Number | Publication Date |
---|---|
US3562820A true US3562820A (en) | 1971-02-16 |
Family
ID=3601064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US661900A Expired - Lifetime US3562820A (en) | 1966-08-22 | 1967-08-21 | Tubular sheet and strip form prostheses on a basis of biological tissue |
Country Status (4)
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US (1) | US3562820A (en) |
AT (1) | AT261800B (en) |
DE (1) | DE1617330B1 (en) |
GB (1) | GB1195992A (en) |
Cited By (198)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2422383A1 (en) * | 1973-05-11 | 1974-11-21 | Rodney C Perkins | SYNTHETIC ANATOMICAL LINKS AND METHOD OF MANUFACTURING THEM |
US3866609A (en) * | 1972-04-05 | 1975-02-18 | Charles Howard Sparks | Apparatus for growing graft tubes in place |
US3894530A (en) * | 1973-07-06 | 1975-07-15 | Irving I Dardik | Method for repairing, augmenting, or replacing a body conduit or organ |
US3974526A (en) * | 1973-07-06 | 1976-08-17 | Dardik Irving I | Vascular prostheses and process for producing the same |
US3988782A (en) * | 1973-07-06 | 1976-11-02 | Dardik Irving I | Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same |
US3993078A (en) * | 1974-11-04 | 1976-11-23 | Gambro Ag | Insert for use preferably in vascular surgery |
US4061134A (en) * | 1975-10-28 | 1977-12-06 | Samuels Peter B | Arterial graft device |
US4130904A (en) * | 1977-06-06 | 1978-12-26 | Thermo Electron Corporation | Prosthetic blood conduit |
WO1984003036A1 (en) * | 1983-02-03 | 1984-08-16 | Wallsten Hans Ivar | Blood vessel prosthesis |
US4483339A (en) * | 1982-01-29 | 1984-11-20 | Rolando Gillis | Vascular surgery roll |
JPS60106460A (en) * | 1983-08-03 | 1985-06-11 | シレイ・インコ−ポレ−テツド | Artificial blood vessel |
US4553974A (en) * | 1984-08-14 | 1985-11-19 | Mayo Foundation | Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor |
US4629458A (en) * | 1985-02-26 | 1986-12-16 | Cordis Corporation | Reinforcing structure for cardiovascular graft |
WO1987001930A1 (en) * | 1985-09-25 | 1987-04-09 | Kern Seymour P | Method of manufacture and implantation of corneal inlays |
US4759758A (en) * | 1984-12-07 | 1988-07-26 | Shlomo Gabbay | Prosthetic heart valve |
US4772283A (en) * | 1986-05-16 | 1988-09-20 | White Thomas C | Corneal implant |
US4787899A (en) * | 1983-12-09 | 1988-11-29 | Lazarus Harrison M | Intraluminal graft device, system and method |
US4798606A (en) * | 1985-02-26 | 1989-01-17 | Corvita Corporation | Reinforcing structure for cardiovascular graft |
US4842599A (en) * | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
US4850999A (en) * | 1980-05-24 | 1989-07-25 | Institute Fur Textil-Und Faserforschung Of Stuttgart | Flexible hollow organ |
WO1990000395A1 (en) * | 1988-07-11 | 1990-01-25 | Purdue Research Foundation | Tissue graft composition and method |
US4956178A (en) * | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5514176A (en) * | 1995-01-20 | 1996-05-07 | Vance Products Inc. | Pull apart coil stent |
WO1996031226A1 (en) * | 1995-04-07 | 1996-10-10 | Purdue Research Foundation | Large area submucosal graft constructs and method for making the same |
US5573784A (en) * | 1991-09-24 | 1996-11-12 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5628788A (en) * | 1995-11-07 | 1997-05-13 | Corvita Corporation | Self-expanding endoluminal stent-graft |
US5645860A (en) * | 1995-04-07 | 1997-07-08 | Purdue Research Foundation | Tissue graft and method for urinary urothelium reconstruction replacement |
US5662700A (en) * | 1983-12-09 | 1997-09-02 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
WO1997037613A1 (en) * | 1996-04-05 | 1997-10-16 | Depuy Orthopaedics, Inc. | Tissue graft construct for replacement of cartilaginous structures |
US5700269A (en) * | 1995-06-06 | 1997-12-23 | Corvita Corporation | Endoluminal prosthesis deployment device for use with prostheses of variable length and having retraction ability |
US5714582A (en) * | 1995-03-17 | 1998-02-03 | Bioscience Consultants | Invertebrate type V telopeptide collagen, methods of making, and use thereof |
US5733337A (en) * | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US5741333A (en) * | 1995-04-12 | 1998-04-21 | Corvita Corporation | Self-expanding stent for a medical device to be introduced into a cavity of a body |
US5755791A (en) * | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US5785679A (en) * | 1995-07-19 | 1998-07-28 | Endotex Interventional Systems, Inc. | Methods and apparatus for treating aneurysms and arterio-venous fistulas |
US5849037A (en) * | 1995-04-12 | 1998-12-15 | Corvita Corporation | Self-expanding stent for a medical device to be introduced into a cavity of a body, and method for its preparation |
US5858556A (en) * | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
US5865723A (en) * | 1995-12-29 | 1999-02-02 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US5873906A (en) * | 1994-09-08 | 1999-02-23 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US5876432A (en) * | 1994-04-01 | 1999-03-02 | Gore Enterprise Holdings, Inc. | Self-expandable helical intravascular stent and stent-graft |
US5879383A (en) * | 1994-04-29 | 1999-03-09 | W. L. Gore & Associates, Inc. | Blood contact surfaces using endothelium on a subendothelial matrix |
US5911757A (en) * | 1991-05-16 | 1999-06-15 | Seare, Jr.; William J. | Methods and apparatus for transcutaneous access |
US5925061A (en) * | 1997-01-13 | 1999-07-20 | Gore Enterprise Holdings, Inc. | Low profile vascular stent |
US5968091A (en) * | 1996-03-26 | 1999-10-19 | Corvita Corp. | Stents and stent grafts having enhanced hoop strength and methods of making the same |
US6001123A (en) * | 1994-04-01 | 1999-12-14 | Gore Enterprise Holdings Inc. | Folding self-expandable intravascular stent-graft |
EP0965310A1 (en) * | 1996-12-06 | 1999-12-22 | Tapic International Co., Ltd. | Artificial blood vessel |
US6042605A (en) * | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
US6077217A (en) * | 1997-06-25 | 2000-06-20 | Ramus Medical Technologies, Inc. | System and method for assembling graft structures |
US6126686A (en) * | 1996-12-10 | 2000-10-03 | Purdue Research Foundation | Artificial vascular valves |
US6187039B1 (en) | 1996-12-10 | 2001-02-13 | Purdue Research Foundation | Tubular submucosal graft constructs |
US6221102B1 (en) | 1983-12-09 | 2001-04-24 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US6331188B1 (en) | 1994-08-31 | 2001-12-18 | Gore Enterprise Holdings, Inc. | Exterior supported self-expanding stent-graft |
US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US6337389B1 (en) | 1995-03-17 | 2002-01-08 | Bioscience Consultants, L.L.C. | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof |
US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
EP1177800A1 (en) * | 2000-08-04 | 2002-02-06 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US6348065B1 (en) | 1995-03-01 | 2002-02-19 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US6352561B1 (en) | 1996-12-23 | 2002-03-05 | W. L. Gore & Associates | Implant deployment apparatus |
US6352553B1 (en) | 1995-12-14 | 2002-03-05 | Gore Enterprise Holdings, Inc. | Stent-graft deployment apparatus and method |
US20020099436A1 (en) * | 1996-12-23 | 2002-07-25 | Troy Thornton | Kink-resistant bifurcated prosthesis |
US20020103542A1 (en) * | 2000-09-18 | 2002-08-01 | Bilbo Patrick R. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
US20020116049A1 (en) * | 2000-09-22 | 2002-08-22 | Scimed Life Systems, Inc. | Stent |
US20020161429A1 (en) * | 1996-04-26 | 2002-10-31 | Jang G. David | Intravascular stent |
US20020169500A1 (en) * | 1996-04-26 | 2002-11-14 | Jang G. David | Intravascular stent |
US6494904B1 (en) | 1996-12-27 | 2002-12-17 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US20020193870A1 (en) * | 1996-04-26 | 2002-12-19 | Jang G. David | Intravascular stent |
US20020193886A1 (en) * | 1998-03-23 | 2002-12-19 | Anne Claeson | Implants and method of making |
US20030021827A1 (en) * | 2001-07-16 | 2003-01-30 | Prasanna Malaviya | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US20030026787A1 (en) * | 1999-08-06 | 2003-02-06 | Fearnot Neal E. | Tubular graft construct |
US20030032961A1 (en) * | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
US20030033022A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration device and method |
US20030036797A1 (en) * | 2001-07-16 | 2003-02-20 | Prasanna Malaviya | Meniscus regeneration device and method |
US20030044444A1 (en) * | 2001-07-16 | 2003-03-06 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20030049299A1 (en) * | 2001-07-16 | 2003-03-13 | Prasanna Malaviya | Porous delivery scaffold and method |
US20030054022A1 (en) * | 1999-12-22 | 2003-03-20 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030065379A1 (en) * | 1994-04-29 | 2003-04-03 | Babbs Charles F. | Reduction of stent thrombogenicity |
US20030078617A1 (en) * | 2001-07-16 | 2003-04-24 | Schwartz Herbert E. | Unitary surgical device and method |
US20030083736A1 (en) * | 1995-03-01 | 2003-05-01 | Brian J. Brown | Longitudinally flexible expandable stent |
US20030088309A1 (en) * | 2001-10-09 | 2003-05-08 | Olympus Optical Co., Ltd. | Stent |
US20030093144A1 (en) * | 1998-02-02 | 2003-05-15 | Scimed Life Systems, Inc. | Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal-connectors |
US6572650B1 (en) | 1998-06-05 | 2003-06-03 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
US20030130747A1 (en) * | 1998-06-05 | 2003-07-10 | Organogenesis, Inc. | Bioengineered flat sheet graft prostheses |
US20030149472A1 (en) * | 1995-11-07 | 2003-08-07 | Leonard Pinchuk | Modular endluminal stent-grafts and methods for their use |
US20030158607A1 (en) * | 1995-04-07 | 2003-08-21 | Carr Robert M. | Tissue repair fabric |
US20030167088A1 (en) * | 1998-06-05 | 2003-09-04 | Organogenesis, Inc. | Bioengineered vascular graft prostheses |
US20030171824A1 (en) * | 1998-06-05 | 2003-09-11 | Organogenesis, Inc. | Bioengineered tubular graft prostheses |
US20030187498A1 (en) * | 2002-03-28 | 2003-10-02 | Medtronic Ave, Inc. | Chamfered stent strut and method of making same |
US20030206860A1 (en) * | 1998-12-01 | 2003-11-06 | Bleyer Mark W. | Radiopaque implantable collagenous biomaterial device |
US6645342B2 (en) | 2002-03-08 | 2003-11-11 | William M. Scott | Pull strip for forming holes |
US6656219B1 (en) | 1987-10-19 | 2003-12-02 | Dominik M. Wiktor | Intravascular stent |
US20040002723A1 (en) * | 2002-06-27 | 2004-01-01 | Robert Ball | Method and apparatus for implantation of soft tissue implant |
US20040039246A1 (en) * | 2001-07-27 | 2004-02-26 | Barry Gellman | Medical slings |
US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
US20040078076A1 (en) * | 1996-08-23 | 2004-04-22 | Badylak Stephen F. | Purified submucosa graft material |
US20040079043A1 (en) * | 2002-03-08 | 2004-04-29 | Scott William M. | Pull strip for forming holes |
US20040098042A1 (en) * | 2002-06-03 | 2004-05-20 | Devellian Carol A. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US20040106985A1 (en) * | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
US20040127969A1 (en) * | 1987-04-06 | 2004-07-01 | Lazarus Harrison M. | Artificial graft and implantation method |
US20040133271A1 (en) * | 2000-09-22 | 2004-07-08 | Jang G. David | Intravascular stent and assembly |
US20040137042A1 (en) * | 1996-08-23 | 2004-07-15 | Hiles Michael C | Multi-formed collagenous biomaterial medical device |
US20040143344A1 (en) * | 2001-07-16 | 2004-07-22 | Prasanna Malaviya | Implantable tissue repair device and method |
US20040158185A1 (en) * | 1998-12-01 | 2004-08-12 | Moran Christopher J. | Embolization device |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
US20040176834A1 (en) * | 1995-03-01 | 2004-09-09 | Brown Brian J. | Longitudinally flexible expandable stent |
US20040176855A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Decellularized liver for repair of tissue and treatment of organ deficiency |
US6790220B2 (en) * | 2001-06-08 | 2004-09-14 | Morris Innovative Research, Inc. | Method and apparatus for sealing access |
US6814748B1 (en) | 1995-06-07 | 2004-11-09 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US6846323B2 (en) | 2003-05-15 | 2005-01-25 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US20050025838A1 (en) * | 2003-06-25 | 2005-02-03 | Badylak Stephen F. | Conditioned compositions for tissue restoration |
US20050038520A1 (en) * | 2003-08-11 | 2005-02-17 | Francois Binette | Method and apparatus for resurfacing an articular surface |
US6860901B1 (en) | 1988-03-09 | 2005-03-01 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US20050071012A1 (en) * | 2003-09-30 | 2005-03-31 | Hassan Serhan | Methods and devices to replace spinal disc nucleus pulposus |
US20050113910A1 (en) * | 2002-01-04 | 2005-05-26 | David Paniagua | Percutaneously implantable replacement heart valve device and method of making same |
US20050136764A1 (en) * | 2003-12-18 | 2005-06-23 | Sherman Michael C. | Designed composite degradation for spinal implants |
US6939377B2 (en) | 2000-08-23 | 2005-09-06 | Thoratec Corporation | Coated vascular grafts and methods of use |
US20050249771A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050273155A1 (en) * | 2002-08-20 | 2005-12-08 | Bahler Clinton D | Endoluminal device with extracellular matrix material and methods |
US6981986B1 (en) | 1995-03-01 | 2006-01-03 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20060058835A1 (en) * | 1999-09-27 | 2006-03-16 | Yuichi Murayama | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
US20060128296A1 (en) * | 2004-10-29 | 2006-06-15 | Schwan Wade E | Intestine processing device and associated method |
US20060136047A1 (en) * | 2002-09-06 | 2006-06-22 | Obermiller F J | Tissue graft prosthesis devices containing juvenile or small diameter submucosa |
US20060135638A1 (en) * | 2004-12-22 | 2006-06-22 | Pedrozo Hugo A | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
WO2006135297A1 (en) * | 2005-06-16 | 2006-12-21 | Sinova Safetech Innovation Ab | Bowel implant |
US20070038245A1 (en) * | 2001-06-08 | 2007-02-15 | Morris Edward J | Dilator |
US20070038244A1 (en) * | 2001-06-08 | 2007-02-15 | Morris Edward J | Method and apparatus for sealing access |
US20070073384A1 (en) * | 1995-03-01 | 2007-03-29 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20070112411A1 (en) * | 2004-02-09 | 2007-05-17 | Obermiller F J | Stent graft devices having collagen coating |
US20070112360A1 (en) * | 2005-11-15 | 2007-05-17 | Patrick De Deyne | Bioprosthetic device |
US20070150064A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Methods and devices for intervertebral augmentation |
US20070150063A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Devices for intervertebral augmentation and methods of controlling their delivery |
US20070150059A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Methods and devices for intervertebral augmentation using injectable formulations and enclosures |
US20070219618A1 (en) * | 2006-03-17 | 2007-09-20 | Cully Edward H | Endoprosthesis having multiple helically wound flexible framework elements |
US20070224237A1 (en) * | 2006-03-24 | 2007-09-27 | Julia Hwang | Barbed sutures having a therapeutic agent thereon |
US20070239195A1 (en) * | 2004-05-18 | 2007-10-11 | Nocca David J | Adjustable Prosthetic Band |
WO2007147739A2 (en) * | 2006-06-22 | 2007-12-27 | Orthomed | Collagen tubes |
US7361195B2 (en) | 2001-07-16 | 2008-04-22 | Depuy Products, Inc. | Cartilage repair apparatus and method |
US20080107665A1 (en) * | 2005-10-27 | 2008-05-08 | University Of Notre Dame Du Lac | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US20080140094A1 (en) * | 2006-12-11 | 2008-06-12 | Schwartz Herbert E | Unitary surgical device and method |
US20080145397A1 (en) * | 1998-12-01 | 2008-06-19 | Hiles Michael C | Multi-formed collagenous biomaterial medical device |
US20080167724A1 (en) * | 2006-12-18 | 2008-07-10 | Med Institute, Inc. | Stent graft with releasable therapeutic agent and soluable coating |
US20080213335A1 (en) * | 1996-08-23 | 2008-09-04 | Cook William A | Graft prosthesis, materials and methods |
US20080260800A1 (en) * | 2005-10-27 | 2008-10-23 | Suckow Mark A | Extracellular matrix cancer vaccine adjuvant |
WO2008134541A2 (en) * | 2007-04-25 | 2008-11-06 | Musculoskeletal Transplant Foundation | Reinforced biological mesh for surgical reinforcement |
US20080319531A1 (en) * | 1995-03-01 | 2008-12-25 | Boston Scientific Scimed, Inc. | Flexible and expandable stent |
US20080319460A1 (en) * | 2005-10-03 | 2008-12-25 | Pietro Cortellini | Patch For Replacement of a Portion of Bladder Wall Following Partial Cystectomy |
US20090024106A1 (en) * | 2007-07-17 | 2009-01-22 | Morris Edward J | Method and apparatus for maintaining access |
US20090048669A1 (en) * | 2004-10-28 | 2009-02-19 | Flagle Jacob A | Methods and systems for modifying vascular valves |
WO2009040768A2 (en) * | 2007-09-27 | 2009-04-02 | Carlos Alvarado | Tissue grafting method |
US20090220461A1 (en) * | 2008-02-28 | 2009-09-03 | University Of Notre Dame | Metastasis inhibition preparations and methods |
US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
US20090306688A1 (en) * | 2008-06-10 | 2009-12-10 | Patel Umesh H | Quilted implantable graft |
US20100076555A1 (en) * | 2008-09-19 | 2010-03-25 | Marten Lewis H | Coated devices comprising a fiber mesh imbedded in the device walls |
US20100228337A1 (en) * | 2009-03-04 | 2010-09-09 | Abbott Laboratories Vascular Enterprises Limited | Mirror image stent and method of use |
US20100233214A1 (en) * | 2005-10-27 | 2010-09-16 | University Of Notre Dame Du Lac | Extracellular matrix cancer vaccine adjuvant |
US20100303886A1 (en) * | 2008-03-14 | 2010-12-02 | Janis Abram D | Graft materials and methods for staged delivery of bioactive components |
US20110020418A1 (en) * | 2009-07-22 | 2011-01-27 | Bosley Jr Rodney W | Particulate Tissue Graft with Components of Differing Density and Methods of Making and Using the Same |
US20110020420A1 (en) * | 2009-07-22 | 2011-01-27 | Bosley Jr Rodney W | Variable Density Tissue Graft Composition and Methods of Making and Using the Same |
US20110150934A1 (en) * | 2009-12-18 | 2011-06-23 | University Of Notre Dame | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer |
US20110166673A1 (en) * | 2008-06-10 | 2011-07-07 | Patel Umesh H | Quilted implantable graft |
US7988720B2 (en) | 2006-09-12 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US7993365B2 (en) | 2001-06-08 | 2011-08-09 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US8070792B2 (en) | 2000-09-22 | 2011-12-06 | Boston Scientific Scimed, Inc. | Stent |
US8118832B1 (en) | 2008-06-16 | 2012-02-21 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US8257715B1 (en) | 2004-08-26 | 2012-09-04 | University Of Notre Dame | Tissue vaccines and uses thereof |
US8361144B2 (en) | 2010-03-01 | 2013-01-29 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve and methods associated therewith |
US8449607B2 (en) | 2007-12-18 | 2013-05-28 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
US8663313B2 (en) | 2011-03-03 | 2014-03-04 | Boston Scientific Scimed, Inc. | Low strain high strength stent |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US8691259B2 (en) | 2000-12-21 | 2014-04-08 | Depuy Mitek, Llc | Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US8696744B2 (en) | 2011-05-27 | 2014-04-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix material valve conduit and methods of making thereof |
US8778362B2 (en) | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof |
US8790388B2 (en) | 2011-03-03 | 2014-07-29 | Boston Scientific Scimed, Inc. | Stent with reduced profile |
US8846059B2 (en) | 2009-12-08 | 2014-09-30 | University Of Notre Dame | Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer |
US8895045B2 (en) | 2003-03-07 | 2014-11-25 | Depuy Mitek, Llc | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US9023342B2 (en) | 2007-09-27 | 2015-05-05 | Carlos A. Alvarado | Tissue grafting method |
US9119738B2 (en) | 2010-06-28 | 2015-09-01 | Colibri Heart Valve Llc | Method and apparatus for the endoluminal delivery of intravascular devices |
US9211362B2 (en) | 2003-06-30 | 2015-12-15 | Depuy Mitek, Llc | Scaffold for connective tissue repair |
US9511171B2 (en) | 2002-10-18 | 2016-12-06 | Depuy Mitek, Llc | Biocompatible scaffolds with tissue fragments |
WO2017034600A1 (en) | 2015-08-21 | 2017-03-02 | Cormatrix Cardiovascular, Inc. | Extracellular matrix prostheses for treating damaged biological tissue |
US20170233945A1 (en) * | 2016-02-15 | 2017-08-17 | Modern Meadow, Inc. | Method for biofabricating composite material |
US9737400B2 (en) | 2010-12-14 | 2017-08-22 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets |
US20180308394A1 (en) * | 2010-06-30 | 2018-10-25 | Stuart Charles Segall | Wearable Partial Task Surgical Simulator |
US10575973B2 (en) | 2018-04-11 | 2020-03-03 | Abbott Cardiovascular Systems Inc. | Intravascular stent having high fatigue performance |
US10687934B2 (en) | 2016-07-05 | 2020-06-23 | Carlos A. Alvarado | Serous membrane for ocular surface disorders |
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US11214844B2 (en) | 2017-11-13 | 2022-01-04 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
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US11495143B2 (en) | 2010-06-30 | 2022-11-08 | Strategic Operations, Inc. | Emergency casualty care trainer |
US11688303B2 (en) | 2010-06-30 | 2023-06-27 | Strategic Operations, Inc. | Simulated torso for an open surgery simulator |
US11854427B2 (en) | 2010-06-30 | 2023-12-26 | Strategic Operations, Inc. | Wearable medical trainer |
US11913166B2 (en) | 2015-09-21 | 2024-02-27 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH632921A5 (en) * | 1978-04-06 | 1982-11-15 | Intermedicat Gmbh | Method of producing bend-free, elastic, puncture-tight vascular protheses |
CA2045222A1 (en) * | 1990-07-12 | 1992-01-13 | Norman R. Weldon | Composite biosynthetic graft |
GB2298577B (en) * | 1995-03-09 | 1999-02-17 | Univ Bristol | Arteriovenous bypass grafting |
-
1966
- 1966-08-22 AT AT795866A patent/AT261800B/en active
- 1966-09-20 DE DE1966B0089013 patent/DE1617330B1/en active Pending
-
1967
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- 1967-08-21 US US661900A patent/US3562820A/en not_active Expired - Lifetime
Cited By (427)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3866609A (en) * | 1972-04-05 | 1975-02-18 | Charles Howard Sparks | Apparatus for growing graft tubes in place |
US4014971A (en) * | 1973-05-11 | 1977-03-29 | Perkins Rodney C | Method for making a tympanic membrane prosthesis |
US4077069A (en) * | 1973-05-11 | 1978-03-07 | Perkins Rodney C | Synthetic tympanic membrane |
DE2422383A1 (en) * | 1973-05-11 | 1974-11-21 | Rodney C Perkins | SYNTHETIC ANATOMICAL LINKS AND METHOD OF MANUFACTURING THEM |
US3974526A (en) * | 1973-07-06 | 1976-08-17 | Dardik Irving I | Vascular prostheses and process for producing the same |
US3988782A (en) * | 1973-07-06 | 1976-11-02 | Dardik Irving I | Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same |
US3894530A (en) * | 1973-07-06 | 1975-07-15 | Irving I Dardik | Method for repairing, augmenting, or replacing a body conduit or organ |
US3993078A (en) * | 1974-11-04 | 1976-11-23 | Gambro Ag | Insert for use preferably in vascular surgery |
US4061134A (en) * | 1975-10-28 | 1977-12-06 | Samuels Peter B | Arterial graft device |
US4130904A (en) * | 1977-06-06 | 1978-12-26 | Thermo Electron Corporation | Prosthetic blood conduit |
US4850999A (en) * | 1980-05-24 | 1989-07-25 | Institute Fur Textil-Und Faserforschung Of Stuttgart | Flexible hollow organ |
US4483339A (en) * | 1982-01-29 | 1984-11-20 | Rolando Gillis | Vascular surgery roll |
WO1984003036A1 (en) * | 1983-02-03 | 1984-08-16 | Wallsten Hans Ivar | Blood vessel prosthesis |
JPS60106460A (en) * | 1983-08-03 | 1985-06-11 | シレイ・インコ−ポレ−テツド | Artificial blood vessel |
JPS6344382B2 (en) * | 1983-08-03 | 1988-09-05 | Shiley Inc | |
US5662700A (en) * | 1983-12-09 | 1997-09-02 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
US6610085B1 (en) | 1983-12-09 | 2003-08-26 | Endovascular Technologies, Inc. | Intraluminal repair device and method |
US4787899A (en) * | 1983-12-09 | 1988-11-29 | Lazarus Harrison M | Intraluminal graft device, system and method |
US6221102B1 (en) | 1983-12-09 | 2001-04-24 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US6017364A (en) * | 1983-12-09 | 2000-01-25 | Endovascular Technologies, Inc. | Intraluminal repair device and catheter |
US4553974A (en) * | 1984-08-14 | 1985-11-19 | Mayo Foundation | Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor |
US4759758A (en) * | 1984-12-07 | 1988-07-26 | Shlomo Gabbay | Prosthetic heart valve |
US4629458A (en) * | 1985-02-26 | 1986-12-16 | Cordis Corporation | Reinforcing structure for cardiovascular graft |
US4798606A (en) * | 1985-02-26 | 1989-01-17 | Corvita Corporation | Reinforcing structure for cardiovascular graft |
US4676790A (en) * | 1985-09-25 | 1987-06-30 | Kern Seymour P | Method of manufacture and implantation of corneal inlays |
WO1987001930A1 (en) * | 1985-09-25 | 1987-04-09 | Kern Seymour P | Method of manufacture and implantation of corneal inlays |
US4772283A (en) * | 1986-05-16 | 1988-09-20 | White Thomas C | Corneal implant |
US4842599A (en) * | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
US20040127969A1 (en) * | 1987-04-06 | 2004-07-01 | Lazarus Harrison M. | Artificial graft and implantation method |
US6416535B1 (en) | 1987-04-06 | 2002-07-09 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
US6923828B1 (en) | 1987-10-19 | 2005-08-02 | Medtronic, Inc. | Intravascular stent |
US6656219B1 (en) | 1987-10-19 | 2003-12-02 | Dominik M. Wiktor | Intravascular stent |
US6702844B1 (en) | 1988-03-09 | 2004-03-09 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
US7166125B1 (en) | 1988-03-09 | 2007-01-23 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US6860901B1 (en) | 1988-03-09 | 2005-03-01 | Endovascular Technologies, Inc. | Intraluminal grafting system |
WO1990000395A1 (en) * | 1988-07-11 | 1990-01-25 | Purdue Research Foundation | Tissue graft composition and method |
US4902508A (en) * | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
US4956178A (en) * | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
AU613499B2 (en) * | 1988-07-11 | 1991-08-01 | Purdue Research Foundation | Tissue graft composition and method |
US20040064180A1 (en) * | 1989-08-24 | 2004-04-01 | Boneau Michael D. | Endovascular support device and method |
US6827733B2 (en) | 1989-08-24 | 2004-12-07 | Medtronic Ave, Inc. | Endovascular support device and method |
US20050119726A1 (en) * | 1989-08-24 | 2005-06-02 | Medtronic Vascular, Inc. | Endovascular support device and method |
US6663661B2 (en) | 1989-08-24 | 2003-12-16 | Medtronic Ave, Inc. | Endovascular support device and method |
US5911757A (en) * | 1991-05-16 | 1999-06-15 | Seare, Jr.; William J. | Methods and apparatus for transcutaneous access |
US5573784A (en) * | 1991-09-24 | 1996-11-12 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5651174A (en) * | 1992-03-19 | 1997-07-29 | Medtronic, Inc. | Intravascular radially expandable stent |
US5443496A (en) * | 1992-03-19 | 1995-08-22 | Medtronic, Inc. | Intravascular radially expandable stent |
US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
US6890351B2 (en) * | 1994-02-18 | 2005-05-10 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US6165210A (en) * | 1994-04-01 | 2000-12-26 | Gore Enterprise Holdings, Inc. | Self-expandable helical intravascular stent and stent-graft |
US5876432A (en) * | 1994-04-01 | 1999-03-02 | Gore Enterprise Holdings, Inc. | Self-expandable helical intravascular stent and stent-graft |
US6017362A (en) * | 1994-04-01 | 2000-01-25 | Gore Enterprise Holdings, Inc. | Folding self-expandable intravascular stent |
US6001123A (en) * | 1994-04-01 | 1999-12-14 | Gore Enterprise Holdings Inc. | Folding self-expandable intravascular stent-graft |
US20030065379A1 (en) * | 1994-04-29 | 2003-04-03 | Babbs Charles F. | Reduction of stent thrombogenicity |
US5879383A (en) * | 1994-04-29 | 1999-03-09 | W. L. Gore & Associates, Inc. | Blood contact surfaces using endothelium on a subendothelial matrix |
US6331188B1 (en) | 1994-08-31 | 2001-12-18 | Gore Enterprise Holdings, Inc. | Exterior supported self-expanding stent-graft |
US6517570B1 (en) | 1994-08-31 | 2003-02-11 | Gore Enterprise Holdings, Inc. | Exterior supported self-expanding stent-graft |
US8623065B2 (en) | 1994-08-31 | 2014-01-07 | W. L. Gore & Associates, Inc. | Exterior supported self-expanding stent-graft |
US5919225A (en) * | 1994-09-08 | 1999-07-06 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US20030208260A1 (en) * | 1994-09-08 | 2003-11-06 | Lilip Lau | Procedures for introducing stents and stent-grafts |
US6613072B2 (en) | 1994-09-08 | 2003-09-02 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US6015429A (en) * | 1994-09-08 | 2000-01-18 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US5873906A (en) * | 1994-09-08 | 1999-02-23 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US5514176A (en) * | 1995-01-20 | 1996-05-07 | Vance Products Inc. | Pull apart coil stent |
US8348992B2 (en) | 1995-03-01 | 2013-01-08 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20070073384A1 (en) * | 1995-03-01 | 2007-03-29 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6962603B1 (en) | 1995-03-01 | 2005-11-08 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US7204848B1 (en) | 1995-03-01 | 2007-04-17 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US8728147B2 (en) | 1995-03-01 | 2014-05-20 | Boston Scientific Limited | Longitudinally flexible expandable stent |
US8449597B2 (en) | 1995-03-01 | 2013-05-28 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US8801773B2 (en) | 1995-03-01 | 2014-08-12 | Boston Scientific Scimed, Inc. | Flexible and expandable stent |
US20080319531A1 (en) * | 1995-03-01 | 2008-12-25 | Boston Scientific Scimed, Inc. | Flexible and expandable stent |
US20040176834A1 (en) * | 1995-03-01 | 2004-09-09 | Brown Brian J. | Longitudinally flexible expandable stent |
US6981986B1 (en) | 1995-03-01 | 2006-01-03 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US8142489B2 (en) | 1995-03-01 | 2012-03-27 | Boston Scientific Scimed, Inc. | Flexible and expandable stent |
US20030083736A1 (en) * | 1995-03-01 | 2003-05-01 | Brian J. Brown | Longitudinally flexible expandable stent |
US7988717B2 (en) | 1995-03-01 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6913619B2 (en) | 1995-03-01 | 2005-07-05 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US8114146B2 (en) | 1995-03-01 | 2012-02-14 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6348065B1 (en) | 1995-03-01 | 2002-02-19 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US6818014B2 (en) | 1995-03-01 | 2004-11-16 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US20040181276A1 (en) * | 1995-03-01 | 2004-09-16 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US6916910B2 (en) | 1995-03-17 | 2005-07-12 | Bioscience Consultants | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof |
US20020147154A1 (en) * | 1995-03-17 | 2002-10-10 | Lloyd Wolfinbarger | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof |
US5714582A (en) * | 1995-03-17 | 1998-02-03 | Bioscience Consultants | Invertebrate type V telopeptide collagen, methods of making, and use thereof |
US6337389B1 (en) | 1995-03-17 | 2002-01-08 | Bioscience Consultants, L.L.C. | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof |
WO1996031226A1 (en) * | 1995-04-07 | 1996-10-10 | Purdue Research Foundation | Large area submucosal graft constructs and method for making the same |
US20030158607A1 (en) * | 1995-04-07 | 2003-08-21 | Carr Robert M. | Tissue repair fabric |
US7060103B2 (en) | 1995-04-07 | 2006-06-13 | Organogenesis Inc. | Tissue repair fabric |
US5711969A (en) * | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
US7909886B2 (en) | 1995-04-07 | 2011-03-22 | Organogenesis, Inc. | Tissue repair fabric |
US5645860A (en) * | 1995-04-07 | 1997-07-08 | Purdue Research Foundation | Tissue graft and method for urinary urothelium reconstruction replacement |
US5955110A (en) * | 1995-04-07 | 1999-09-21 | Purdue Research Foundation, Inc. | Multilayered submucosal graft constructs and method for making the same |
US5885619A (en) * | 1995-04-07 | 1999-03-23 | Purdue Research Foundation | Large area submucosal tissue graft constructs and method for making the same |
US5733337A (en) * | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
JP2012101100A (en) * | 1995-04-07 | 2012-05-31 | Organogenesis Inc | Peracetic acid crosslinked non-antigenic icl grafts |
US5762966A (en) * | 1995-04-07 | 1998-06-09 | Purdue Research Foundation | Tissue graft and method for urinary tract urothelium reconstruction and replacement |
US5741333A (en) * | 1995-04-12 | 1998-04-21 | Corvita Corporation | Self-expanding stent for a medical device to be introduced into a cavity of a body |
US5849037A (en) * | 1995-04-12 | 1998-12-15 | Corvita Corporation | Self-expanding stent for a medical device to be introduced into a cavity of a body, and method for its preparation |
US6237460B1 (en) | 1995-04-12 | 2001-05-29 | Corvita Corporation | Method for preparation of a self-expanding stent for a medical device to be introduced into a cavity of a body |
US5700269A (en) * | 1995-06-06 | 1997-12-23 | Corvita Corporation | Endoluminal prosthesis deployment device for use with prostheses of variable length and having retraction ability |
US6814748B1 (en) | 1995-06-07 | 2004-11-09 | Endovascular Technologies, Inc. | Intraluminal grafting system |
US5785679A (en) * | 1995-07-19 | 1998-07-28 | Endotex Interventional Systems, Inc. | Methods and apparatus for treating aneurysms and arterio-venous fistulas |
US5628788A (en) * | 1995-11-07 | 1997-05-13 | Corvita Corporation | Self-expanding endoluminal stent-graft |
US20030149472A1 (en) * | 1995-11-07 | 2003-08-07 | Leonard Pinchuk | Modular endluminal stent-grafts and methods for their use |
US8323328B2 (en) | 1995-12-14 | 2012-12-04 | W. L. Gore & Associates, Inc. | Kink resistant stent-graft |
US6042605A (en) * | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
US6520986B2 (en) | 1995-12-14 | 2003-02-18 | Gore Enterprise Holdings, Inc. | Kink resistant stent-graft |
US6352553B1 (en) | 1995-12-14 | 2002-03-05 | Gore Enterprise Holdings, Inc. | Stent-graft deployment apparatus and method |
US6361637B2 (en) | 1995-12-14 | 2002-03-26 | Gore Enterprise Holdings, Inc. | Method of making a kink resistant stent-graft |
US20030130721A1 (en) * | 1995-12-14 | 2003-07-10 | Martin Gerald Ray | Kink resistant stent-graft |
US5865723A (en) * | 1995-12-29 | 1999-02-02 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
AU720362B2 (en) * | 1995-12-29 | 2000-06-01 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US5968091A (en) * | 1996-03-26 | 1999-10-19 | Corvita Corp. | Stents and stent grafts having enhanced hoop strength and methods of making the same |
US5968096A (en) * | 1996-04-05 | 1999-10-19 | Purdue Research Foundation | Method of repairing perforated submucosal tissue graft constructs |
US5755791A (en) * | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US5997575A (en) * | 1996-04-05 | 1999-12-07 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US5922028A (en) * | 1996-04-05 | 1999-07-13 | Depuy Orthopaedics, Inc. | Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ |
US5788625A (en) * | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US6176880B1 (en) | 1996-04-05 | 2001-01-23 | Depuy Orthopaedics, Inc. | Tissue graft construct for replacement of cartilaginous structures |
WO1997037613A1 (en) * | 1996-04-05 | 1997-10-16 | Depuy Orthopaedics, Inc. | Tissue graft construct for replacement of cartilaginous structures |
US6793676B2 (en) | 1996-04-05 | 2004-09-21 | Depuy Orthopaedics, Inc. | Method of reconstructing a joint |
US7326241B2 (en) | 1996-04-26 | 2008-02-05 | Boston Scientific Scimed, Inc. | Intravascular stent |
US7081130B2 (en) | 1996-04-26 | 2006-07-25 | Boston Scientific Scimed, Inc. | Intravascular Stent |
US20020161429A1 (en) * | 1996-04-26 | 2002-10-31 | Jang G. David | Intravascular stent |
US20020193870A1 (en) * | 1996-04-26 | 2002-12-19 | Jang G. David | Intravascular stent |
US20020161430A1 (en) * | 1996-04-26 | 2002-10-31 | Jang G. David | Intravascular stent |
US20020169500A1 (en) * | 1996-04-26 | 2002-11-14 | Jang G. David | Intravascular stent |
US9078778B2 (en) | 1996-04-26 | 2015-07-14 | Boston Scientific Scimed, Inc. | Intravascular stent |
US6770088B1 (en) | 1996-04-26 | 2004-08-03 | Scimed Life Systems, Inc. | Intravascular stent |
US9445926B2 (en) | 1996-04-26 | 2016-09-20 | Boston Scientific Scimed, Inc. | Intravascular stent |
US8021414B2 (en) | 1996-04-26 | 2011-09-20 | Boston Scientific Scimed, Inc. | Intravascular stent |
US20040106985A1 (en) * | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
US7699895B2 (en) | 1996-08-23 | 2010-04-20 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US20080171092A1 (en) * | 1996-08-23 | 2008-07-17 | Cook William A | Graft prosthesis, materials and methods |
US8920515B2 (en) | 1996-08-23 | 2014-12-30 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20080167727A1 (en) * | 1996-08-23 | 2008-07-10 | Cook William A | Graft prosthesis, materials and methods |
US20080167728A1 (en) * | 1996-08-23 | 2008-07-10 | Cook William A | Graft prosthesis, materials and methods |
US20100104658A2 (en) * | 1996-08-23 | 2010-04-29 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US7652077B2 (en) * | 1996-08-23 | 2010-01-26 | Cook Incorporated | Graft prosthesis, materials and methods |
US8808392B2 (en) | 1996-08-23 | 2014-08-19 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20080063680A1 (en) * | 1996-08-23 | 2008-03-13 | Hiles Michael C | Dried collagenous biomaterial medical device prepared from a urinary tissue source |
US9138444B2 (en) | 1996-08-23 | 2015-09-22 | Cook Biotech Incorporated | Dried collagenous biomaterial medical device |
US20110076329A1 (en) * | 1996-08-23 | 2011-03-31 | Cook William A | Graft prosthesis, material and methods |
US20100106257A2 (en) * | 1996-08-23 | 2010-04-29 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20100106256A2 (en) * | 1996-08-23 | 2010-04-29 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20040078076A1 (en) * | 1996-08-23 | 2004-04-22 | Badylak Stephen F. | Purified submucosa graft material |
US8716227B2 (en) | 1996-08-23 | 2014-05-06 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20080213335A1 (en) * | 1996-08-23 | 2008-09-04 | Cook William A | Graft prosthesis, materials and methods |
US8920516B2 (en) | 1996-08-23 | 2014-12-30 | Cook Biotech Incorporated | Graft prosthesis, material and methods |
US8007542B2 (en) | 1996-08-23 | 2011-08-30 | Cook Biotech Incorporated | Freeze-dried collagenous biomaterial medical sponge device |
US20040180042A1 (en) * | 1996-08-23 | 2004-09-16 | Cook William A. | Graft prosthesis, materials and methods |
US20040137042A1 (en) * | 1996-08-23 | 2004-07-15 | Hiles Michael C | Multi-formed collagenous biomaterial medical device |
US20100104617A2 (en) * | 1996-08-23 | 2010-04-29 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US20080145395A1 (en) * | 1996-08-23 | 2008-06-19 | Hiles Michael C | Multi-formed collagenous biomaterial medical device |
US8128708B2 (en) | 1996-08-23 | 2012-03-06 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device for use in wound care |
EP0965310A1 (en) * | 1996-12-06 | 1999-12-22 | Tapic International Co., Ltd. | Artificial blood vessel |
EP0965310A4 (en) * | 1996-12-06 | 2003-03-19 | Tapic Int Co Ltd | Artificial blood vessel |
US6358284B1 (en) * | 1996-12-10 | 2002-03-19 | Med Institute, Inc. | Tubular grafts from purified submucosa |
US6187039B1 (en) | 1996-12-10 | 2001-02-13 | Purdue Research Foundation | Tubular submucosal graft constructs |
US6126686A (en) * | 1996-12-10 | 2000-10-03 | Purdue Research Foundation | Artificial vascular valves |
US6551350B1 (en) | 1996-12-23 | 2003-04-22 | Gore Enterprise Holdings, Inc. | Kink resistant bifurcated prosthesis |
US20090138066A1 (en) * | 1996-12-23 | 2009-05-28 | Leopold Eric W | Implant Deployment Apparatus |
US7682380B2 (en) | 1996-12-23 | 2010-03-23 | Gore Enterprise Holdings, Inc. | Kink-resistant bifurcated prosthesis |
US20100145434A1 (en) * | 1996-12-23 | 2010-06-10 | Troy Thornton | Kink resistant bifurcated prosthesis |
US20020099436A1 (en) * | 1996-12-23 | 2002-07-25 | Troy Thornton | Kink-resistant bifurcated prosthesis |
US6352561B1 (en) | 1996-12-23 | 2002-03-05 | W. L. Gore & Associates | Implant deployment apparatus |
US6494904B1 (en) | 1996-12-27 | 2002-12-17 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US5925061A (en) * | 1997-01-13 | 1999-07-20 | Gore Enterprise Holdings, Inc. | Low profile vascular stent |
US5858556A (en) * | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
US6077217A (en) * | 1997-06-25 | 2000-06-20 | Ramus Medical Technologies, Inc. | System and method for assembling graft structures |
US20030093144A1 (en) * | 1998-02-02 | 2003-05-15 | Scimed Life Systems, Inc. | Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal-connectors |
US8562665B2 (en) | 1998-02-02 | 2013-10-22 | Boston Scientific Scimed, Inc. | Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal-connectors |
US20020193886A1 (en) * | 1998-03-23 | 2002-12-19 | Anne Claeson | Implants and method of making |
US7041131B2 (en) | 1998-06-05 | 2006-05-09 | Organogenesis, Inc. | Bioengineered vascular graft support prostheses |
US6986735B2 (en) | 1998-06-05 | 2006-01-17 | Organogenesis Inc. | Method of making a bioremodelable vascular graft prosthesis |
US20030195618A1 (en) * | 1998-06-05 | 2003-10-16 | Organogenesis, Inc. | Bioengineered vascular graft support prostheses |
US20030171824A1 (en) * | 1998-06-05 | 2003-09-11 | Organogenesis, Inc. | Bioengineered tubular graft prostheses |
US20060100717A1 (en) * | 1998-06-05 | 2006-05-11 | Organogenesis, Inc. | Bioengineered vascular graft prostheses |
US20030167088A1 (en) * | 1998-06-05 | 2003-09-04 | Organogenesis, Inc. | Bioengineered vascular graft prostheses |
US20030130747A1 (en) * | 1998-06-05 | 2003-07-10 | Organogenesis, Inc. | Bioengineered flat sheet graft prostheses |
US7121999B2 (en) | 1998-06-05 | 2006-10-17 | Organogenesis Inc. | Method of preparing layered graft prostheses |
US6572650B1 (en) | 1998-06-05 | 2003-06-03 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
US7214242B2 (en) | 1998-06-05 | 2007-05-08 | Organogenesis, Inc. | Bioengineered tubular graft prostheses |
US8882850B2 (en) | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US20030206860A1 (en) * | 1998-12-01 | 2003-11-06 | Bleyer Mark W. | Radiopaque implantable collagenous biomaterial device |
US7857825B2 (en) | 1998-12-01 | 2010-12-28 | Cook Biotech Incorporated | Embolization device |
US20040158185A1 (en) * | 1998-12-01 | 2004-08-12 | Moran Christopher J. | Embolization device |
US20100204782A1 (en) * | 1998-12-01 | 2010-08-12 | Bleyer Mark W | Radiopaque implantable collagenous biomaterial device |
US7713552B2 (en) | 1998-12-01 | 2010-05-11 | Cook Biotech Incorporated | Radiopaque implantable collagenous biomaterial device |
US9089626B2 (en) | 1998-12-01 | 2015-07-28 | Cook Biotech Incorporated | Radiopaque implantable collagenous biomaterial device |
US20080145397A1 (en) * | 1998-12-01 | 2008-06-19 | Hiles Michael C | Multi-formed collagenous biomaterial medical device |
EP1985320A1 (en) | 1998-12-01 | 2008-10-29 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
US8439942B2 (en) | 1998-12-01 | 2013-05-14 | Cook Bioteck Incorporated | Embolization device |
US8652191B2 (en) | 1999-08-06 | 2014-02-18 | Cook Biotech Incorporated | Tubular graft construct |
US7485138B2 (en) | 1999-08-06 | 2009-02-03 | Cook Biotech Incorporated | Tubular graft construct |
US20030026787A1 (en) * | 1999-08-06 | 2003-02-06 | Fearnot Neal E. | Tubular graft construct |
US20090187257A1 (en) * | 1999-08-06 | 2009-07-23 | Fearnot Neal E | Tubular graft construct |
US8388643B2 (en) | 1999-09-27 | 2013-03-05 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
US20060058835A1 (en) * | 1999-09-27 | 2006-03-16 | Yuichi Murayama | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
US20030059407A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030059405A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6852339B2 (en) | 1999-12-22 | 2005-02-08 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6849273B2 (en) | 1999-12-22 | 2005-02-01 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6861074B2 (en) | 1999-12-22 | 2005-03-01 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US10092678B2 (en) | 1999-12-22 | 2018-10-09 | Acell, Inc. | Extracellular matrix for the treatment of intestinal disease and methods thereof |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
US6869619B2 (en) | 1999-12-22 | 2005-03-22 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6887495B2 (en) | 1999-12-22 | 2005-05-03 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US9433701B2 (en) | 1999-12-22 | 2016-09-06 | Acell, Inc. | Extracellular matrix for the treatment of intestinal disease and methods thereof |
US6783776B2 (en) | 1999-12-22 | 2004-08-31 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6890563B2 (en) | 1999-12-22 | 2005-05-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030064111A1 (en) * | 1999-12-22 | 2003-04-03 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US9265860B2 (en) | 1999-12-22 | 2016-02-23 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6890562B2 (en) | 1999-12-22 | 2005-05-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030064112A1 (en) * | 1999-12-22 | 2003-04-03 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6893666B2 (en) | 1999-12-22 | 2005-05-17 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030059411A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6890564B2 (en) | 1999-12-22 | 2005-05-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030054022A1 (en) * | 1999-12-22 | 2003-03-20 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030059409A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US20030059404A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making , and method of use thereof |
US20030059410A1 (en) * | 1999-12-22 | 2003-03-27 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US7160333B2 (en) | 2000-08-04 | 2007-01-09 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
EP1177800A1 (en) * | 2000-08-04 | 2002-02-06 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US20070129811A1 (en) * | 2000-08-04 | 2007-06-07 | Plouhar Pamela L | Reinforced small intestinal submucosa |
US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US20040059431A1 (en) * | 2000-08-04 | 2004-03-25 | Plouhar Pamela L. | Reinforced small intestinal submucosa |
US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US7799089B2 (en) | 2000-08-04 | 2010-09-21 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US6939377B2 (en) | 2000-08-23 | 2005-09-06 | Thoratec Corporation | Coated vascular grafts and methods of use |
US20020103542A1 (en) * | 2000-09-18 | 2002-08-01 | Bilbo Patrick R. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
US20040133271A1 (en) * | 2000-09-22 | 2004-07-08 | Jang G. David | Intravascular stent and assembly |
US7766956B2 (en) | 2000-09-22 | 2010-08-03 | Boston Scientific Scimed, Inc. | Intravascular stent and assembly |
US20020116049A1 (en) * | 2000-09-22 | 2002-08-22 | Scimed Life Systems, Inc. | Stent |
US8070792B2 (en) | 2000-09-22 | 2011-12-06 | Boston Scientific Scimed, Inc. | Stent |
US8691259B2 (en) | 2000-12-21 | 2014-04-08 | Depuy Mitek, Llc | Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US20070038245A1 (en) * | 2001-06-08 | 2007-02-15 | Morris Edward J | Dilator |
US20070038244A1 (en) * | 2001-06-08 | 2007-02-15 | Morris Edward J | Method and apparatus for sealing access |
US7993365B2 (en) | 2001-06-08 | 2011-08-09 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US6790220B2 (en) * | 2001-06-08 | 2004-09-14 | Morris Innovative Research, Inc. | Method and apparatus for sealing access |
US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
US20030033022A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration device and method |
US20050027307A1 (en) * | 2001-07-16 | 2005-02-03 | Schwartz Herbert Eugene | Unitary surgical device and method |
US8337537B2 (en) * | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US8012205B2 (en) | 2001-07-16 | 2011-09-06 | Depuy Products, Inc. | Cartilage repair and regeneration device |
US20040220574A1 (en) * | 2001-07-16 | 2004-11-04 | Pelo Mark Joseph | Device from naturally occuring biologically derived materials |
US7361195B2 (en) | 2001-07-16 | 2008-04-22 | Depuy Products, Inc. | Cartilage repair apparatus and method |
US20030021827A1 (en) * | 2001-07-16 | 2003-01-30 | Prasanna Malaviya | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US20040143344A1 (en) * | 2001-07-16 | 2004-07-22 | Prasanna Malaviya | Implantable tissue repair device and method |
US7819918B2 (en) | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US7163563B2 (en) | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
US20030078617A1 (en) * | 2001-07-16 | 2003-04-24 | Schwartz Herbert E. | Unitary surgical device and method |
US20030049299A1 (en) * | 2001-07-16 | 2003-03-13 | Prasanna Malaviya | Porous delivery scaffold and method |
US20030044444A1 (en) * | 2001-07-16 | 2003-03-06 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20030036797A1 (en) * | 2001-07-16 | 2003-02-20 | Prasanna Malaviya | Meniscus regeneration device and method |
US20030032961A1 (en) * | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
US20080167716A1 (en) * | 2001-07-16 | 2008-07-10 | Schwartz Hebert E | Cartilage repair apparatus and method |
US7070558B2 (en) * | 2001-07-27 | 2006-07-04 | Boston Scientific Scimed, Inc. | Medical slings |
US20040039246A1 (en) * | 2001-07-27 | 2004-02-26 | Barry Gellman | Medical slings |
US7131992B2 (en) * | 2001-10-09 | 2006-11-07 | Olympus Corporation | Stent |
US20030088309A1 (en) * | 2001-10-09 | 2003-05-08 | Olympus Optical Co., Ltd. | Stent |
US9186248B2 (en) | 2002-01-04 | 2015-11-17 | Colibri Heart Valve Llc | Percutaneously implantable replacement heart valve device and method of making same |
US8109995B2 (en) | 2002-01-04 | 2012-02-07 | Colibri Heart Valve Llc | Percutaneously implantable replacement heart valve device and method of making same |
US9610158B2 (en) | 2002-01-04 | 2017-04-04 | Colibri Heart Valve Llc | Percutaneously implantable replacement heart valve device and method of making same |
US20090030511A1 (en) * | 2002-01-04 | 2009-01-29 | David Paniagua | Percutaneously implantable replacement heart valve device and method of making same |
US8790398B2 (en) | 2002-01-04 | 2014-07-29 | Colibri Heart Valve Llc | Percutaneously implantable replacement heart valve device and method of making same |
US9125739B2 (en) | 2002-01-04 | 2015-09-08 | Colibri Heart Valve Llc | Percutaneous replacement heart valve and a delivery and implantation system |
US20050113910A1 (en) * | 2002-01-04 | 2005-05-26 | David Paniagua | Percutaneously implantable replacement heart valve device and method of making same |
US9554898B2 (en) | 2002-01-04 | 2017-01-31 | Colibri Heart Valve Llc | Percutaneous prosthetic heart valve |
US8308797B2 (en) | 2002-01-04 | 2012-11-13 | Colibri Heart Valve, LLC | Percutaneously implantable replacement heart valve device and method of making same |
US8900294B2 (en) | 2002-01-04 | 2014-12-02 | Colibri Heart Valve Llc | Method of controlled release of a percutaneous replacement heart valve |
US20040079043A1 (en) * | 2002-03-08 | 2004-04-29 | Scott William M. | Pull strip for forming holes |
US6645342B2 (en) | 2002-03-08 | 2003-11-11 | William M. Scott | Pull strip for forming holes |
US20030187498A1 (en) * | 2002-03-28 | 2003-10-02 | Medtronic Ave, Inc. | Chamfered stent strut and method of making same |
US20040098042A1 (en) * | 2002-06-03 | 2004-05-20 | Devellian Carol A. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US9216014B2 (en) | 2002-06-03 | 2015-12-22 | W.L. Gore & Associates, Inc. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US20070198060A1 (en) * | 2002-06-03 | 2007-08-23 | Nmt Medical, Inc. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US20040002723A1 (en) * | 2002-06-27 | 2004-01-01 | Robert Ball | Method and apparatus for implantation of soft tissue implant |
US7160326B2 (en) | 2002-06-27 | 2007-01-09 | Depuy Products, Inc. | Method and apparatus for implantation of soft tissue implant |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20090248144A1 (en) * | 2002-08-20 | 2009-10-01 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
US20050273155A1 (en) * | 2002-08-20 | 2005-12-08 | Bahler Clinton D | Endoluminal device with extracellular matrix material and methods |
US7550004B2 (en) | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
US7887576B2 (en) | 2002-08-20 | 2011-02-15 | Cook Incorporated | Endoluminal device with extracellular matrix material and methods |
US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
US20060136047A1 (en) * | 2002-09-06 | 2006-06-22 | Obermiller F J | Tissue graft prosthesis devices containing juvenile or small diameter submucosa |
US9511171B2 (en) | 2002-10-18 | 2016-12-06 | Depuy Mitek, Llc | Biocompatible scaffolds with tissue fragments |
US10603408B2 (en) | 2002-10-18 | 2020-03-31 | DePuy Synthes Products, Inc. | Biocompatible scaffolds with tissue fragments |
US20100297212A1 (en) * | 2003-03-07 | 2010-11-25 | Badylak Stephen F | Scaffold for cell growth and differentiation |
US20040176855A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Decellularized liver for repair of tissue and treatment of organ deficiency |
US8895045B2 (en) | 2003-03-07 | 2014-11-25 | Depuy Mitek, Llc | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US20080058956A1 (en) * | 2003-03-07 | 2008-03-06 | Badylak Stephen F | Decellularized liver for repair of tissue and treatment of organ deficiency |
US20100119579A1 (en) * | 2003-03-07 | 2010-05-13 | Badylak Stephen F | Decellularized liver for repair of tissue and treatment of organ deficiency |
US20110097378A1 (en) * | 2003-03-07 | 2011-04-28 | Badylak Stephen F | Decellularized liver for repair of tissue and treatment of organ deficiency |
US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
US6846323B2 (en) | 2003-05-15 | 2005-01-25 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US8409625B2 (en) | 2003-06-25 | 2013-04-02 | Acell, Inc. | Conditioned decellularized native tissues for tissue restoration |
US20050025838A1 (en) * | 2003-06-25 | 2005-02-03 | Badylak Stephen F. | Conditioned compositions for tissue restoration |
US9211362B2 (en) | 2003-06-30 | 2015-12-15 | Depuy Mitek, Llc | Scaffold for connective tissue repair |
US10583220B2 (en) | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
US20050038520A1 (en) * | 2003-08-11 | 2005-02-17 | Francois Binette | Method and apparatus for resurfacing an articular surface |
US20050071012A1 (en) * | 2003-09-30 | 2005-03-31 | Hassan Serhan | Methods and devices to replace spinal disc nucleus pulposus |
US20050136764A1 (en) * | 2003-12-18 | 2005-06-23 | Sherman Michael C. | Designed composite degradation for spinal implants |
US20070112411A1 (en) * | 2004-02-09 | 2007-05-17 | Obermiller F J | Stent graft devices having collagen coating |
US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
US10420636B2 (en) | 2004-02-09 | 2019-09-24 | Cook Medical Technologies Llc | Stent graft devices having collagen coating |
US20050249771A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20070239195A1 (en) * | 2004-05-18 | 2007-10-11 | Nocca David J | Adjustable Prosthetic Band |
US8257715B1 (en) | 2004-08-26 | 2012-09-04 | University Of Notre Dame | Tissue vaccines and uses thereof |
US7833267B2 (en) * | 2004-10-28 | 2010-11-16 | Cook Incorporated | Methods and systems for modifying vascular valves |
US20090048669A1 (en) * | 2004-10-28 | 2009-02-19 | Flagle Jacob A | Methods and systems for modifying vascular valves |
US7513866B2 (en) | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
US20060128296A1 (en) * | 2004-10-29 | 2006-06-15 | Schwan Wade E | Intestine processing device and associated method |
US20060135638A1 (en) * | 2004-12-22 | 2006-06-22 | Pedrozo Hugo A | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
WO2006135297A1 (en) * | 2005-06-16 | 2006-12-21 | Sinova Safetech Innovation Ab | Bowel implant |
US20080195228A1 (en) * | 2005-06-16 | 2008-08-14 | Sinova Safetech Innovation Ab | Bowel Implant |
US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
US7972385B2 (en) * | 2005-10-03 | 2011-07-05 | Antonio Sambusseti | Patch for replacement of a portion of bladder wall following partial cystectomy |
US20080319460A1 (en) * | 2005-10-03 | 2008-12-25 | Pietro Cortellini | Patch For Replacement of a Portion of Bladder Wall Following Partial Cystectomy |
US9308252B2 (en) | 2005-10-27 | 2016-04-12 | Cook Biotech, Inc. | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US9220770B2 (en) | 2005-10-27 | 2015-12-29 | The University Of Notre Dame | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US20080107665A1 (en) * | 2005-10-27 | 2008-05-08 | University Of Notre Dame Du Lac | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US20080260800A1 (en) * | 2005-10-27 | 2008-10-23 | Suckow Mark A | Extracellular matrix cancer vaccine adjuvant |
US8778362B2 (en) | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof |
US20100233214A1 (en) * | 2005-10-27 | 2010-09-16 | University Of Notre Dame Du Lac | Extracellular matrix cancer vaccine adjuvant |
US8802113B2 (en) | 2005-10-27 | 2014-08-12 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US8778360B2 (en) | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US20100136050A1 (en) * | 2005-10-27 | 2010-06-03 | University Of Notre Dame Du Lac | Extracellular Matrix Materials as Vaccine Adjuvants for Diseases Associated with Infectious Pathogens or Toxins |
US20110076305A1 (en) * | 2005-10-27 | 2011-03-31 | University Of Notre Dame Du Lac | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US20070112360A1 (en) * | 2005-11-15 | 2007-05-17 | Patrick De Deyne | Bioprosthetic device |
US20070150064A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Methods and devices for intervertebral augmentation |
US20070150059A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Methods and devices for intervertebral augmentation using injectable formulations and enclosures |
US20070150063A1 (en) * | 2005-12-22 | 2007-06-28 | Depuy Spine, Inc. | Devices for intervertebral augmentation and methods of controlling their delivery |
US20070219618A1 (en) * | 2006-03-17 | 2007-09-20 | Cully Edward H | Endoprosthesis having multiple helically wound flexible framework elements |
US20070224237A1 (en) * | 2006-03-24 | 2007-09-27 | Julia Hwang | Barbed sutures having a therapeutic agent thereon |
WO2007147739A2 (en) * | 2006-06-22 | 2007-12-27 | Orthomed | Collagen tubes |
US20100221291A1 (en) * | 2006-06-22 | 2010-09-02 | Orthomed | Collagen tubes |
FR2902661A1 (en) * | 2006-06-22 | 2007-12-28 | Orthomed Sa | Collagen tube for e.g. regeneration of severed nerve, has wall constituted by succession of co-axial, cylindrical, continuous and non-porous collagen films, where each film has specific thickness, and tube has specific length |
WO2007147739A3 (en) * | 2006-06-22 | 2008-02-21 | Orthomed | Collagen tubes |
US7988720B2 (en) | 2006-09-12 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20080140094A1 (en) * | 2006-12-11 | 2008-06-12 | Schwartz Herbert E | Unitary surgical device and method |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US20080167724A1 (en) * | 2006-12-18 | 2008-07-10 | Med Institute, Inc. | Stent graft with releasable therapeutic agent and soluable coating |
US9474833B2 (en) | 2006-12-18 | 2016-10-25 | Cook Medical Technologies Llc | Stent graft with releasable therapeutic agent and soluble coating |
WO2008134541A2 (en) * | 2007-04-25 | 2008-11-06 | Musculoskeletal Transplant Foundation | Reinforced biological mesh for surgical reinforcement |
US20100185219A1 (en) * | 2007-04-25 | 2010-07-22 | Musculosketetal Transplant Foundation | Reinforced biological mesh for surgical reinforcement |
WO2008134541A3 (en) * | 2007-04-25 | 2010-03-18 | Musculoskeletal Transplant Foundation | Reinforced biological mesh for surgical reinforcement |
US20090024106A1 (en) * | 2007-07-17 | 2009-01-22 | Morris Edward J | Method and apparatus for maintaining access |
US9023342B2 (en) | 2007-09-27 | 2015-05-05 | Carlos A. Alvarado | Tissue grafting method |
WO2009040768A2 (en) * | 2007-09-27 | 2009-04-02 | Carlos Alvarado | Tissue grafting method |
WO2009040768A3 (en) * | 2007-09-27 | 2009-05-14 | Carlos Alvarado | Tissue grafting method |
US20100135964A1 (en) * | 2007-09-27 | 2010-06-03 | Alvarado Carlos A | Tissue grafting method |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US8449607B2 (en) | 2007-12-18 | 2013-05-28 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
US9283266B2 (en) | 2008-02-28 | 2016-03-15 | University Of Notre Dame | Metastasis inhibition preparations and methods |
US20090220461A1 (en) * | 2008-02-28 | 2009-09-03 | University Of Notre Dame | Metastasis inhibition preparations and methods |
US8658196B2 (en) | 2008-03-14 | 2014-02-25 | Cook Biotech Incorporated | Graft materials and methods for staged delivery of bioactive components |
US20100303886A1 (en) * | 2008-03-14 | 2010-12-02 | Janis Abram D | Graft materials and methods for staged delivery of bioactive components |
US10688219B2 (en) | 2008-06-10 | 2020-06-23 | Cook Biotech Incorporated | Quilted implantable graft |
US11351021B2 (en) | 2008-06-10 | 2022-06-07 | Cook Biotech Incorporated | Quilted implantable graft |
US20110166673A1 (en) * | 2008-06-10 | 2011-07-07 | Patel Umesh H | Quilted implantable graft |
US9295757B2 (en) | 2008-06-10 | 2016-03-29 | Cook Biotech Incorporated | Quilted implantable graft |
US20090306688A1 (en) * | 2008-06-10 | 2009-12-10 | Patel Umesh H | Quilted implantable graft |
US8118832B1 (en) | 2008-06-16 | 2012-02-21 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US8974493B2 (en) | 2008-06-16 | 2015-03-10 | Morris Innovative, Inc. | Method and apparatus for sealing access |
US8709080B2 (en) * | 2008-09-19 | 2014-04-29 | E. Benson Hood Laboratories | Coated devices comprising a fiber mesh imbedded in the device walls |
US20100076555A1 (en) * | 2008-09-19 | 2010-03-25 | Marten Lewis H | Coated devices comprising a fiber mesh imbedded in the device walls |
US20100228337A1 (en) * | 2009-03-04 | 2010-09-09 | Abbott Laboratories Vascular Enterprises Limited | Mirror image stent and method of use |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US9579183B2 (en) | 2009-07-22 | 2017-02-28 | Acell, Inc. | Variable density tissue graft composition and methods of making and using the same |
US10517994B2 (en) | 2009-07-22 | 2019-12-31 | Acell, Inc. | Variable density tissue graft composition and methods of making and using the same |
US20110020418A1 (en) * | 2009-07-22 | 2011-01-27 | Bosley Jr Rodney W | Particulate Tissue Graft with Components of Differing Density and Methods of Making and Using the Same |
US20110020420A1 (en) * | 2009-07-22 | 2011-01-27 | Bosley Jr Rodney W | Variable Density Tissue Graft Composition and Methods of Making and Using the Same |
US8962035B2 (en) | 2009-07-22 | 2015-02-24 | Acell, Inc. | Variable density tissue graft composition and methods of making and using the same |
US8298586B2 (en) | 2009-07-22 | 2012-10-30 | Acell Inc | Variable density tissue graft composition |
US11000628B2 (en) | 2009-07-22 | 2021-05-11 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US9561307B2 (en) | 2009-07-22 | 2017-02-07 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US8541032B2 (en) | 2009-07-22 | 2013-09-24 | Acell, Inc. | Tissue graft composition |
US10898610B2 (en) | 2009-07-22 | 2021-01-26 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US11013829B2 (en) | 2009-07-22 | 2021-05-25 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US9056078B2 (en) | 2009-07-22 | 2015-06-16 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US8968761B2 (en) | 2009-07-22 | 2015-03-03 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US8846059B2 (en) | 2009-12-08 | 2014-09-30 | University Of Notre Dame | Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer |
US20110150934A1 (en) * | 2009-12-18 | 2011-06-23 | University Of Notre Dame | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer |
US8361144B2 (en) | 2010-03-01 | 2013-01-29 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve and methods associated therewith |
US9119738B2 (en) | 2010-06-28 | 2015-09-01 | Colibri Heart Valve Llc | Method and apparatus for the endoluminal delivery of intravascular devices |
US20190371206A1 (en) * | 2010-06-30 | 2019-12-05 | Strategic Operations, Inc. | Wearable partial task surgical simulator |
US11854427B2 (en) | 2010-06-30 | 2023-12-26 | Strategic Operations, Inc. | Wearable medical trainer |
US11688303B2 (en) | 2010-06-30 | 2023-06-27 | Strategic Operations, Inc. | Simulated torso for an open surgery simulator |
US11495143B2 (en) | 2010-06-30 | 2022-11-08 | Strategic Operations, Inc. | Emergency casualty care trainer |
US20180308394A1 (en) * | 2010-06-30 | 2018-10-25 | Stuart Charles Segall | Wearable Partial Task Surgical Simulator |
US10360817B2 (en) * | 2010-06-30 | 2019-07-23 | Stuart Charles Segall | Wearable partial task surgical simulator |
US11151902B2 (en) * | 2010-06-30 | 2021-10-19 | Strategic Operations, Inc. | Wearable partial task surgical simulator |
US10973632B2 (en) | 2010-12-14 | 2021-04-13 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets |
US9737400B2 (en) | 2010-12-14 | 2017-08-22 | Colibri Heart Valve Llc | Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets |
US8663313B2 (en) | 2011-03-03 | 2014-03-04 | Boston Scientific Scimed, Inc. | Low strain high strength stent |
US8790388B2 (en) | 2011-03-03 | 2014-07-29 | Boston Scientific Scimed, Inc. | Stent with reduced profile |
US8845719B2 (en) | 2011-05-27 | 2014-09-30 | Cormatrix Cardiovascular, Inc | Extracellular matrix material conduits and methods of making and using same |
US8696744B2 (en) | 2011-05-27 | 2014-04-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix material valve conduit and methods of making thereof |
WO2017034600A1 (en) | 2015-08-21 | 2017-03-02 | Cormatrix Cardiovascular, Inc. | Extracellular matrix prostheses for treating damaged biological tissue |
US11913166B2 (en) | 2015-09-21 | 2024-02-27 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
US11525042B2 (en) | 2016-02-15 | 2022-12-13 | Modern Meadow, Inc. | Composite biofabricated material |
US11530304B2 (en) | 2016-02-15 | 2022-12-20 | Modern Meadow, Inc. | Biofabricated material containing collagen fibrils |
US11001679B2 (en) | 2016-02-15 | 2021-05-11 | Modern Meadow, Inc. | Biofabricated material containing collagen fibrils |
US11286354B2 (en) | 2016-02-15 | 2022-03-29 | Modern Meadow, Inc. | Method for making a biofabricated material containing collagen fibrils |
US10301440B2 (en) | 2016-02-15 | 2019-05-28 | Modern Meadow, Inc. | Biofabricated material containing collagen fibrils |
US10519285B2 (en) * | 2016-02-15 | 2019-12-31 | Modern Meadow, Inc. | Method for biofabricating composite material |
US20170233945A1 (en) * | 2016-02-15 | 2017-08-17 | Modern Meadow, Inc. | Method for biofabricating composite material |
US11542374B2 (en) | 2016-02-15 | 2023-01-03 | Modern Meadow, Inc. | Composite biofabricated material |
US10687934B2 (en) | 2016-07-05 | 2020-06-23 | Carlos A. Alvarado | Serous membrane for ocular surface disorders |
US11395726B2 (en) | 2017-09-11 | 2022-07-26 | Incubar Llc | Conduit vascular implant sealing device for reducing endoleaks |
US11214844B2 (en) | 2017-11-13 | 2022-01-04 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
US10575973B2 (en) | 2018-04-11 | 2020-03-03 | Abbott Cardiovascular Systems Inc. | Intravascular stent having high fatigue performance |
US11352497B2 (en) | 2019-01-17 | 2022-06-07 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
CN111467574B (en) * | 2020-04-21 | 2021-01-26 | 四川大学 | Biological valve material based on EDC/NHS activation and recombinant human collagen modification and preparation method thereof |
CN111467574A (en) * | 2020-04-21 | 2020-07-31 | 四川大学 | Biological valve material based on EDC/NHS activation and recombinant human collagen modification and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
DE1617330B1 (en) | 1971-01-28 |
GB1195992A (en) | 1970-06-24 |
AT261800B (en) | 1968-05-10 |
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