US3894530A - Method for repairing, augmenting, or replacing a body conduit or organ - Google Patents

Method for repairing, augmenting, or replacing a body conduit or organ Download PDF

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Publication number
US3894530A
US3894530A US37694873A US3894530A US 3894530 A US3894530 A US 3894530A US 37694873 A US37694873 A US 37694873A US 3894530 A US3894530 A US 3894530A
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Prior art keywords
method
body
cord
vein
augmenting
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Expired - Lifetime
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Irving I Dardik
Herbert Dardik
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Irving I Dardik
Herbert Dardik
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Application filed by Irving I Dardik, Herbert Dardik filed Critical Irving I Dardik
Priority to US05376948 priority Critical patent/US3894530A/en
Priority claimed from US05/543,462 external-priority patent/US3974526A/en
Priority claimed from US05/563,998 external-priority patent/US3988782A/en
Application granted granted Critical
Publication of US3894530A publication Critical patent/US3894530A/en
Assigned to DARDIK, SHEILA, PLAINTIFF reassignment DARDIK, SHEILA, PLAINTIFF CERTIFIED COPY OR ORDER, FILED IN THE SUPERIOR COURT, BERGEN COUNTY, N.J. DISTRIBUTING A 25% INTEREST IN SAID PATENT TO ASSIGNEE FILEDAPRIL 12, 1991. Assignors: DARDIK, IRVING, DEFENDANT D.D.
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Application status is Expired - Lifetime legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625Vascular tissue, e.g. heart valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels

Abstract

The umbilical cord is used for grafts in the vascular system or other body conduits, such as the ureter.

Description

United States Patent [1 1 Dardik et al.

[451 July 15,1975

Dardik, 806 Washburn St., Teaneck, NJ. 07666 [22] Filed: July 6, 1973 [21] Appl. No.: 376,948

[52] U.S. Cl 128/1 R; 3/1; 3/l.4; 128/334 R [51] Int. Cl. A61B 19/00; A6lF l/24 [58] Field of Search 3/l, DIG.1, 1.4; 128/334 R, 334 C, 335.5, 335, l R

[56] References Cited UNITED STATES PATENTS 3,408,659 ll/l968 Thiele et al 3/l 3,562,820 2/l97l Braun 3/DIG. 1

OTHER PUBLICATIONS The Use of Umbilical Cord for Reconstruction of Abdominal Wall Defects by Frederick C. Heaton et al., Surgical Forum, Vol. 21, 1970, pp. 56-57.

Preparation and Use of Freeze-Dried Arterial Homografts by O. Creech et al., Annals of Surgery, Vol. 140, No. 1, July, 1954, pp. 35-43.

Primary ExaminerRonald L. Frinks Attorney, Agent, or Firm-Blum Moscovitz Friedman & Kaplan ABSTRACT The umbilical cord is used for grafts in the vascular system or other body conduits, such as the ureter.

5 Claims, No Drawings 1 METHOD FOR REPAIRING, AUGMENTING, OR REPLACING A BODY CONDUIT OR ORGAN A major problem in vascular reconstructive surgery is how effectively to.supply blood to organs and tissues whose blood vessels are inadequate either through congenital defects or acquired disorders such as trauma, arteriosclerosis and other diseases. Various techniques and materials have been devised to excise and replace blood vessels, to bypass blood vessels, and to patch, i.e., widen the channel of vessels. Initially arterial homografts (human arteries) were used to restore continuity but limited supply, inadequate sizes, development of aneurysms and atherosclerosis necessitated the search for a better substitute. A great advance was the development of the partially porous and pliable plastic cloth graft.

The following is a list of the various problems which one runs into with artificially made grafts:

1. Infection in a foreign body graft is catastrophic,

often leading to hemorrhage, sepsis and death.

2. The inner lining is thrombogenic, predisposed to clotting of the graft and distal embolism of the clot.

3. The rigidity of cloth grafts may result in twisting and kinking, especially in areas of crossing a joint.

4. Because of clotting difficulties, smaller caliber artificial grafts are frequently unsuccessful.

The many problems posed by artificially manufactured prostheses have led investigators again to seek newer and better methods. These include new techniques of cleaning out an artery such as carbodissection, widening arteries by dilatation, development of bovine heterografts, creating collagen tubes within the recipient patient for later use as a graft (Silicone Mandrel).

Saphenous veins, both autografts (patient is donor) and allografts or homografts (from another human), are now being used to advantage. However, there are problems of unavailability, small size, non uniform caliber, time required for harvesting, intraluminal valves and easy twisting leading to occlusion. The number of new methods being continually devised attests to the need for a better material.

According to the present invention, the structures of the human umbilical cord are used for grafts in the vascular system or other body conduits such as the ureter, in mammals, particularly primates, including man. At birth, after division from the baby, the cord itself is traditionally discarded. The umbilical cord is composed of a vein and two arteries surrounded by a substance called Whartons jelly. It varies in length from inches to almost 2 feet. It is highly flexible and strong. Both arteries and the vein are suitable for use in surgery. Composite grafts and patches can be made in various sizes and shapes. A list of uses follows, either as a conduit or as a patch of any kind in the body:

1. Arterial substitute 2. Vein substitute 3. Ureter substitute 4. Common bile duct substitute 5. As an arteriovenous fistula for hemodialysis 6. As a patch to close any visceral or vascular defect, or to wrap around and protect a suture line of any kind.

The umbilical cord may be used fresh or as a stored homograft (frozen or in a preservative). It may require treatment with antibiotics or other chemicals or drugs and x-ray treatment for sterilization. It may be antigenic and require treatment, for example with enzymes, to remove any antigenic substances. The cord may be freeze dried or stored in a cold environment or preserved in other known ways as to be used as an autograft if necessary for the baby whenever needed at a future date. The cord may be somewhat coiled and may require mechanical or chemical techniques to straighten it out if necessary. Cords from premature babies or from early pregnancy can be used (i.e., in

smaller vessels).

The advantages of using umbilical vessels as a conduit or a patch are as follows:

1. easy availability 2. marked flexibility 3. marked strength 4. highly smooth, natural inner lining may inhibit clotting 5. less likely to become infected 6. relative lack of antigenicity 7. uniform diameter 8. variable size available for both large and small vessels 9. good length 10. contains 3 vessels each of which can be used EXAMPLE The following example illustrates the technique of vascular surgical interposition of the umbilical cord vessel derived from the human, into the abdominal aorta of an animal, for example a dog and a baboon.

The animal, in this case a baboon, was prepared under general anesthesia and sterile conditions for making an abdominal incision. The baboon was prepared and shaved and a longitudinal incision was made in the midline of the abdomen. The incision extended from the xythoid to the pubic area and was carried down through the midline and into the peritoneal cavity. Bleeding vessels were clamped and ligated with 3-0 plyglycollic acid sutures. The peritoneal cavity was entered and the viscera and bowel were explored for any other diseases. The animal was found to be normal. The bowel and viscera were walled off with cloth pads and retractors. The peritoneum overlying the aorta was incised and the aorta immobilized by sharp and blunt dissection. Lumbar arteries were individually clamped and ligated with 3-0 silk suture so that the segment of abdominal aorta extending from the infra-renal arteries to the bifurcation of the aorta was immobilized. The entire segment of abdominal aorta was thus made available for transplant of the umbilical cord. During preparation of the abdominal aorta of the baboon, another investigator had taken the umbilical cord of an infant (human) that had been born two hours prior to the surgical intervention of the baboon. The cord had been delivered and taken in its entirety and transported in sterile saline solution, packed in ice. The purpose of freezing the umbilical cord in ice was to prevent any further decomposition of the cord structure. The cord, prior to insertion, was washed and irrigated numerous times with sterile Collins solution with antibiotics, in this particular instance, 1 percent cephalosporin solution and 25,000 units of bacitracin per liter of solution. The blood was thoroughly washed out from within the vessels of the cord and the cord was also irrigated with a 1 percent heparin anticoagulant solution. Following this thorough cleansing of the cord, one end of the umbilical vein within the cord which was to be used as the transplant was clamped with a clamp and through the other end a red rubber catheter, No. 14 French, was introduced and the vein was distended. At this point a suitable segment of umbilical graft, approximately 5 centimeters in length, was selected for excision. This segment of cord was then sterilely handled and placed into the operating field. At this point the animal was heparinized with 2,500 units of aqueous heparin given intravenously. The abdominal aorta was then clamped proximally and distally to the segment to be resected. A segment of approximately 3 centimeters in length was resected from the abdominal aorta and an end-toend anastomosis was performed between host aorta and donor umbilical vein, first using continuous 6-0 prolene suture which is a nylon monofilament suture. The distal anastomosis was then performed following flushing of the aorta to rid it of any clot material and debris. Following completion of anastomosis the distal and then the proximal clamps were removed. It was noted that there was no bleeding between the interstices of the sutures, which is unusual, and is felt to be due to the strength and self-sealing gelatinous qualities of the cord structure. Excellent pulses were noted to be present in the graft as well as the distal iliac vessels. The area was lavaged with with saline and suctioned. The retroperitoneum was closed with interrupted 3-0 polyglycollic acid sutures and the viscera was replaced. The animal, throughout the procedure thus far, was stable; the respiration and vital signs were normal. The abdominal wall was then closed in layers using continuous 0 silk for the posterior fascia and peritoneum and interrupted 2-0 silk sutures for the anterior fascia. The skin was approximated with continuous 3-0 nylon suture. The anesthesia used in this procedure was nembutal. The blood loss estimated during the procedure was approximately 50 to cc. The animal tolerated the procedure well and awoke within 30 minutes. Postoperatively on the following day the animal was sitting and walking in its cage, and on the third postoperative day was eating its regular diet and was allowed out of its cage to roam around and climb up and down the walls, and appearedto be in excellent health. The legs were warm and pulses were intact in the extremities.

A number of procedures will become apparent to those skilled in the art. If desired or necessary, the vein or artery of the umbilical cord may be split longitudinally and formed into composites of larger diameter. The umbilical cord or a portion thereof may be used to reinforce, support or seal a weakened area or defect of any body structure, such as the heart, the heart valves or urinary bladder. Such procedures are included within the scope of the claims.

I claim:

1. A method for repairing, augmenting or replacing a vein or artery of the body of a primate which comprises suturing or otherwise securing a portion of a vein or artery of an umbilical cord of a primate into or onto the wall of such body vein or artery.

2. A method as described in claim 1 wherein the umbilical cord is from a human infant.

3. A method as described in claim 1 wherein an artery of the body is repaired, augmented or replaced.

4. A method as described in claim 1 wherein the cord is from a human and said body is that of a primate other than the donor.

5. A method as described in claim 1 wherein a vein of the body is repaired, augmented or replaced.

Claims (5)

1. A method for repairing, augmenting or replacing a vein or artery of the body of a primate which comprises suturing or otherwise securing a portion of a vein or artery of an umbilical cord of a primate into or onto the wall of such body vein or artery.
2. A method as described in claim 1 wherein the umbilical cord is from a human infant.
3. A method as described in claim 1 wherein an artery of the body is repaired, augmented or replaced.
4. A method as described in claim 1 wherein the cord is from a human and said body is that of a primate other than the donor.
5. A method as described in claim 1 wherein a vein of the body is repaired, augmented or replaced.
US05376948 1973-07-06 1973-07-06 Method for repairing, augmenting, or replacing a body conduit or organ Expired - Lifetime US3894530A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US05376948 US3894530A (en) 1973-07-06 1973-07-06 Method for repairing, augmenting, or replacing a body conduit or organ

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05376948 US3894530A (en) 1973-07-06 1973-07-06 Method for repairing, augmenting, or replacing a body conduit or organ
US05/543,462 US3974526A (en) 1973-07-06 1975-01-23 Vascular prostheses and process for producing the same
US05/563,998 US3988782A (en) 1973-07-06 1975-04-01 Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same
BE158256A BE831318A (en) 1973-07-06 1975-07-11 Improvements to elements used in surgical grafts

Related Child Applications (1)

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US05/543,462 Continuation-In-Part US3974526A (en) 1973-07-06 1975-01-23 Vascular prostheses and process for producing the same

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974526A (en) * 1973-07-06 1976-08-17 Dardik Irving I Vascular prostheses and process for producing the same
WO1982000091A1 (en) * 1980-07-01 1982-01-21 V Ketharanathan Vascular prostheses
WO1982004390A1 (en) * 1981-06-10 1982-12-23 Kenneth Z Kurland Means and method of implanting bioprosthetics
EP0070328A1 (en) * 1981-07-21 1983-01-26 Theurer, Karl Eugen, Prof.Dr.med. Use of egg membranes and umbilical cord in unmodified or modified form
US4487567A (en) * 1983-03-24 1984-12-11 Possis Medical, Inc. Apparatus for making a vascular graft
US4546499A (en) * 1982-12-13 1985-10-15 Possis Medical, Inc. Method of supplying blood to blood receiving vessels
US4915893A (en) * 1982-07-16 1990-04-10 Medtronic, Inc. Method of preparing polyester filament material
US4990131A (en) * 1987-09-01 1991-02-05 Herbert Dardik Tubular prostheses for vascular reconstructive surgery and process for preparing same
US5110852A (en) * 1982-07-16 1992-05-05 Rijksuniversiteit Te Groningen Filament material polylactide mixtures
US5114672A (en) * 1990-08-27 1992-05-19 Cryo-Cell International, Inc. Method for preserving blood fluid
WO1997003624A1 (en) * 1995-07-19 1997-02-06 Renan Uflacker Adjustable and retrievable graft and graft delivery system for stent-graft system and methods of implantation
WO1998025546A1 (en) 1996-12-10 1998-06-18 Cook Biotech, Inc. Tubular grafts from purified submucosa
US5865723A (en) * 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US6077217A (en) * 1997-06-25 2000-06-20 Ramus Medical Technologies, Inc. System and method for assembling graft structures
US20020040246A1 (en) * 1991-08-12 2002-04-04 Bonutti Peter M. Tissue press and system
US20020055755A1 (en) * 1990-06-28 2002-05-09 Bonutti Peter M. Apparatus and method for tissue removal
US6494904B1 (en) 1996-12-27 2002-12-17 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US20030050708A1 (en) * 1991-08-12 2003-03-13 Bonutti Peter M. Tissue grafting material
US20040126404A1 (en) * 1998-08-21 2004-07-01 University Of Queensland Of St. Lucia Implant material
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US7294144B1 (en) * 1998-08-10 2007-11-13 Schneider James R Preserved implantable vessel derived from a human umbilical cord or placenta
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
US20080268017A1 (en) * 1998-08-21 2008-10-30 The University Of Queensland Of St. Lucia Method of producing tissue by placing a molding support within a body cavity
US8747439B2 (en) 2000-03-13 2014-06-10 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
US8814902B2 (en) 2000-05-03 2014-08-26 Bonutti Skeletal Innovations Llc Method of securing body tissue
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US8845687B2 (en) 1996-08-19 2014-09-30 Bonutti Skeletal Innovations Llc Anchor for securing a suture
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
US9814563B1 (en) * 2014-04-25 2017-11-14 David M. Hoganson Hemodynamically optimized shunt

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3408659A (en) * 1964-07-25 1968-11-05 Thiele Heinrich Artificial blood vessels and process of making same
US3562820A (en) * 1966-08-22 1971-02-16 Bernhard Braun Tubular sheet and strip form prostheses on a basis of biological tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3408659A (en) * 1964-07-25 1968-11-05 Thiele Heinrich Artificial blood vessels and process of making same
US3562820A (en) * 1966-08-22 1971-02-16 Bernhard Braun Tubular sheet and strip form prostheses on a basis of biological tissue

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974526A (en) * 1973-07-06 1976-08-17 Dardik Irving I Vascular prostheses and process for producing the same
WO1982000091A1 (en) * 1980-07-01 1982-01-21 V Ketharanathan Vascular prostheses
US4466139A (en) * 1980-07-01 1984-08-21 Vettivetpillai Ketharanathan Vascular prostheses
WO1982004390A1 (en) * 1981-06-10 1982-12-23 Kenneth Z Kurland Means and method of implanting bioprosthetics
US4400833A (en) * 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
EP0070328A1 (en) * 1981-07-21 1983-01-26 Theurer, Karl Eugen, Prof.Dr.med. Use of egg membranes and umbilical cord in unmodified or modified form
US4915893A (en) * 1982-07-16 1990-04-10 Medtronic, Inc. Method of preparing polyester filament material
US5110852A (en) * 1982-07-16 1992-05-05 Rijksuniversiteit Te Groningen Filament material polylactide mixtures
US4546499A (en) * 1982-12-13 1985-10-15 Possis Medical, Inc. Method of supplying blood to blood receiving vessels
US4601718A (en) * 1982-12-13 1986-07-22 Possis Medical, Inc. Vascular graft and blood supply method
US4562597A (en) * 1982-12-13 1986-01-07 Possis Medical, Inc. Method of supplying blood to blood receiving vessels
DE3390385C2 (en) * 1982-12-13 1994-07-07 Possis Medical Inc vascular implants
US4487567A (en) * 1983-03-24 1984-12-11 Possis Medical, Inc. Apparatus for making a vascular graft
US4990131A (en) * 1987-09-01 1991-02-05 Herbert Dardik Tubular prostheses for vascular reconstructive surgery and process for preparing same
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US7896880B2 (en) 1990-06-28 2011-03-01 P Tech, Llc Apparatus and method for tissue removal
US20020099401A1 (en) * 1990-06-28 2002-07-25 Bonutti Petel M. Apparatus and method for tissue removal
US20020055755A1 (en) * 1990-06-28 2002-05-09 Bonutti Peter M. Apparatus and method for tissue removal
US7134437B2 (en) 1990-06-28 2006-11-14 Bonutti Ip, Llc Method for utilizing human tissue
US5114672A (en) * 1990-08-27 1992-05-19 Cryo-Cell International, Inc. Method for preserving blood fluid
US6905517B2 (en) 1991-08-12 2005-06-14 Bonutti Ip, Llp Tissue grafting material
US7070557B2 (en) 1991-08-12 2006-07-04 Marctec, Llc Tissue graft material and method of making
US20020040246A1 (en) * 1991-08-12 2002-04-04 Bonutti Peter M. Tissue press and system
US7462200B2 (en) 1991-08-12 2008-12-09 Marctec, Llc Method for tissue grafting
US7727283B2 (en) 1991-08-12 2010-06-01 P Tech, Llc. Tissue stabilizing implant method
US6989029B2 (en) 1991-08-12 2006-01-24 Bonutti Ip, Llc Tissue cage
US20030050708A1 (en) * 1991-08-12 2003-03-13 Bonutti Peter M. Tissue grafting material
US20030130744A1 (en) * 1991-08-12 2003-07-10 Bonutti Peter M. Tissue cage
US6630000B1 (en) * 1991-08-12 2003-10-07 Bonutti 2003 Trust-A Method of using body tissue
US20040172140A1 (en) * 1991-08-12 2004-09-02 Bonutti Peter M. Tissue stabilizing implant
WO1997003624A1 (en) * 1995-07-19 1997-02-06 Renan Uflacker Adjustable and retrievable graft and graft delivery system for stent-graft system and methods of implantation
US5713948A (en) * 1995-07-19 1998-02-03 Uflacker; Renan Adjustable and retrievable graft and graft delivery system for stent-graft system
US5776186A (en) * 1995-07-19 1998-07-07 Endotex Interventional Systems, Inc. Adjustable and retrievable graft and graft delivery system for stent-graft system and methods of implantation
US5865723A (en) * 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US8845687B2 (en) 1996-08-19 2014-09-30 Bonutti Skeletal Innovations Llc Anchor for securing a suture
WO1998025546A1 (en) 1996-12-10 1998-06-18 Cook Biotech, Inc. Tubular grafts from purified submucosa
WO1998025543A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Tubular submucosal graft constructs
US6494904B1 (en) 1996-12-27 2002-12-17 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US6077217A (en) * 1997-06-25 2000-06-20 Ramus Medical Technologies, Inc. System and method for assembling graft structures
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
US7294144B1 (en) * 1998-08-10 2007-11-13 Schneider James R Preserved implantable vessel derived from a human umbilical cord or placenta
US20080268017A1 (en) * 1998-08-21 2008-10-30 The University Of Queensland Of St. Lucia Method of producing tissue by placing a molding support within a body cavity
US20040126404A1 (en) * 1998-08-21 2004-07-01 University Of Queensland Of St. Lucia Implant material
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US8747439B2 (en) 2000-03-13 2014-06-10 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US8814902B2 (en) 2000-05-03 2014-08-26 Bonutti Skeletal Innovations Llc Method of securing body tissue
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
US9814563B1 (en) * 2014-04-25 2017-11-14 David M. Hoganson Hemodynamically optimized shunt

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AS Assignment

Owner name: DARDIK, SHEILA, PLAINTIFF

Free format text: CERTIFIED COPY OR ORDER, FILED IN THE SUPERIOR COURT, BERGEN COUNTY, N.J. DISTRIBUTING A 25% INTEREST IN SAID PATENT TO ASSIGNEE FILEDAPRIL 12, 1991.;ASSIGNOR:DARDIK, IRVING, DEFENDANT D.D.;REEL/FRAME:005674/0653

Effective date: 19841224