US3552591A - Pierceable closure for medicine bottles - Google Patents

Pierceable closure for medicine bottles Download PDF

Info

Publication number
US3552591A
US3552591A US880483A US3552591DA US3552591A US 3552591 A US3552591 A US 3552591A US 880483 A US880483 A US 880483A US 3552591D A US3552591D A US 3552591DA US 3552591 A US3552591 A US 3552591A
Authority
US
United States
Prior art keywords
disc
teflon
covering
closure
stuck
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US880483A
Other languages
English (en)
Inventor
Hans Wimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
West Pharmaceutical Services Inc
Original Assignee
West Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Co Inc filed Critical West Co Inc
Application granted granted Critical
Publication of US3552591A publication Critical patent/US3552591A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Definitions

  • a medicine bottle closure that can be stuck through, with a flanged cap and with a sealing disc, which is made of at least two different materials and which is anchored on the front face of the bottle mouth, characterized in that a sealing disc 3 which seals the flat front face 5 of the' bottle mouth la, which is made with a bevel-off 6 of its outer rim, consists of a layer, preferably of a Teflon disc 8 or of a similar foil, which covers the bottle opening and approximately half the bottleneck front-face 5 annular area delimited by its outer and inner diameters, and consists of an elastomeric gastight covering disc 7 which covers the bottle opening and the entire front face, upon the middle zone of which disc is applied the Teflon disc 8, and characterized in that this covering disc 7 carries at its outer rim, as an anchorage, a ridge 712 that fits the bevel 6 at the outer rim of the bottle mouth.
  • closure for medicine bottles, which can be stuck through and which has a sealing disc anchored relatively to the bottle mouth.
  • anchoring is formed of an annular protruding head of the bottle mouth which cooperates with a corresponding annular groove provided in the sealing disc.
  • the sealing disc In the case of medicine bottles it is however, often desired that the sealing disc shall have a number of materials, of which the material of the side turned toward the inside of the bottle should in particular be chemically inert, while the outer part of the sealing disc should eliminate certain disadvantages of the first-named part and/or should be less expensive material, for forming the cheaper part of the sealing disc.
  • Such a process has the drawback that the adhesive, under the relatively high temperature of the following vulcanization operation, readily becomes resinified or hardened, through which it is no'longer possible to use a bottle closure consisting of such sealing discs to meet the purpose of the invention, as a closure, for medicine bottles, that can be stuck through to remove the content of the bottle by means of a cannula, because for the removal of the medicament the rubber disc together with the Teflon disc have to be stuck through, and
  • the fundamental problem of the invention is to create for medicine bottles a closure that can be stuck through, consisting of a sealing disc that has a material that is chemically inert whereby there is obtained above all a reliable sealing and also sufficient anchorage of the sealing disc, and furthermore the cost of making such a medicine bottle and its closure comes out as cheap as possible, and the problem includes creating a process for the production of a sealing disc consisting ofat least two different materials, by which process, preferably,- a
  • Teflon disc is vulcanized on a rubber disc without it being necessary to use an adhesive as a bonding means.
  • the invention proposes that, in the case of a medicine bottle closure that can be stuck through,
  • this closure be made in such a way that a sealing disc which rim, asan anchorage, a ridge that fits the bevel at the outer rim of the bottle mouth.
  • this relatively expensive Teflon disc can be thin, and at the outer zone of the bottle front face there is a covering disc that is gastight and sufficiently elastic to complete the seal, and it can also,,in association with the ridge at its outer rim and the flanged cap form an anchorage.
  • a particularly favorable and reliable anchorage is obtaine when the ridge of the covering disc is made substantially wedge-shaped is so dimensioned that it becomes clamped tightly after the flanging-in of the cap.
  • the middle zone of the covering disc which carries the Teflon disc or the like, can be sur-. rounded by an annular groove.
  • the angle of bevel of the ridge of the covering disc can be flatter than the bevel on the bottle mouth, so that the apex of the ridge, in its unformed state, projects somewhat over the rest of the diameter of the covering disc.
  • the Teflon disc can be bent a little inwardly into the annular groove.
  • the adhesive effect can be retained for a short time in the cold state while 'the just produced rubber mixture is still unpowdered. In all cases the important thing is that the rubber mixture, when after its production it is still unpowdered, has its adhesive effect utilized.
  • the process of the invention affords the advantage that the application of a roughened covering disc or foil, preferably made of Teflon, enables this foil to stick tightly when it is applied directly after the production of the raw-rubber plate, made from a rubber mixture, while it is in a fresh state before being powdered, through which it is unnecessary to use a sticky medium as an adhesive, with all the aforesaid drawbacks.
  • a further advantage of the process of the invention is that it becomes possible for the foil to project somewhat over the stamped-out round parts, so that these projecting edges can be bent over, for better anchorage in the rubber part, by the pressure from the press.
  • FIG. 1 shows a vertical lengthwise section through the upper part of a medicine bottle having a closure that can be stuck through
  • FIG. 2 shows to an enlarged scale a partial section through the sealing
  • FIG. 3 shows a cross section through the cutting tool in which is situated the Teflon foil and the preshaped hardened raw-rubber plate, with the Teflon disc applied to it, and this namely directly prior to the cutting operation;
  • FIG. 4 shows the cutout disc blank, provided with the Teflon foil, while it is being brought into the vulcanization mold, shown in section;
  • FIG. 5 shows in section the finished sealing disc, in the closed vulcanization mold shown in section.
  • a medicine bottle 1 has a closure designated as a whole by 2.
  • This closure has a two-part sealing disc 3, which is fastened by means of a flanged cap 4 to the bottle mouth designated as a whole by la.
  • the flanged cap 4 hereby is in known wise set in the middle zone of a so-called tear-off tab 4a, and through tearing upward this tab the middle region of the sealing disc 3 is exposed, so that it is possible to stick through it, for example a hollow needle, a cannula or the like, and then to draw off part or all of the bottles contents.
  • Medicine bottles 1 having such closures 2 are often used as infusion flasks, whereby a hollow needle of fairly large diameter is frequently stuck through the sealing disc 3.
  • the front face 5 of the bottle mount 1a is in known wise made flat, and it is part of the invention that it has at its outer rim'an annular bevel 6.
  • the sealing disc 3 consists of two parts: namely a covering disc 7 and a thin Teflon disc 8.
  • the covering disc 7 is made of an elastomeric gastight material, of butyl rubber for example.
  • the middle zone of the covering disc, surrounded by an annular groove 9, is covered by a Teflon disc 8, which is fastened on by the process of the invention.
  • the diameter of the Teflon disc 8 and the inner diameter of the annular groove 9 are respectively so that about half the bottleneck front-face annular area 5 delimited by its outer and inner diameters is covered by the Teflon disc 8.
  • Teflon disc 3 is near the annular groove 9 in the covering disc 7 bent upward at its rim
  • Teflon disc 8 has a better hold in the radial direction also.
  • the aforesaid annular groove 9, whose shape is. ad vantageous for centering the raw-rubber plate 7a inv the vulcanizing mold (FIGS. 41 and 5), has advantages evenafter the bottle is closed: it then acts so to say asalabyrinth lf a perfect seal is practically never obtained between the Teflon disc 8 and the front face 5 of the bottle mouth becauseTeflQnor a similarly hard material is unable to adapt, itself sufficiently to unevennesses of the glass, there still remains a labyrinthlike annular space between the Teflon disc and the zone-.the covering disc 7 bears against.
  • This groove exerts a barrier effect particularly when there prevails in it a pressure greater than prevails in the interior of the bottle, for example in the case of evacuated bottles.
  • an above-normal pressure may be produced in the annularigroove 9 and be maintained there, for a certain time at'least.
  • This pressure difference then prevents any slowly emerging contents of the bottle from creeping between the bottle front face 5 and the Teflon disc 8, so as to then react chemically withthe-covering disc 7 and exert a marked reaction on the contents of the bottle. Slight quantities of the contents of the bottle that go radially outside the Teflon disc 8 to enter into reaction with the covering disc 7 would for the greater part remain in theannular groove 9.
  • a substantial part of the invention is represented by the bevel 6 of the bottle mouth in cooperation with the ridge 7b at the outer rim of the covering disc 7.
  • the dimensions of the ridge are adapted to the bevel 6 at the outer rim of the bottle mouth, and it is made somewhat wedge-shaped with its apex turned downward, and it is preferably dimensioned so that during the flanging-in of the flanged cap 4 it becomes clamped tightly on the bottle mouth.
  • the aforesaid clamping attachment of the sealing disc 7 is needed in particular for processing the medicine bottles in completely automatic flanging machines, because these flanging machineson account of the tolerances of the glass medicine bottle l"--do not always operate with the same flanging pressure, so that the flanged cap 4 does not always receive the same flanging pressure, and thus the pressure on the glass rim, over which the flanging takes place, is not always uniform. It is true that the flanging pressure can be adjusted so that a sufficientsealing of liquids is obtained; however a sufficient sealing against gases can not be obtained.
  • the bevel angle a FIG.
  • a covering disc 7 is made from a specially composed rubber mixture, which meets most of the requirement relatively to the contents to be sealed in the bottle, and which has raw-rubber surface adhesiveness, which vanishes after vulcanization at the places exposed to the air and generally powdered, and which has the property of adhering to a roughened Teflon foil.
  • a Teflon foil 8 For this purpose there is applied on such a raw-rubber plate 7a while it is still hot, directly after it has been produced, a Teflon foil 8, with its roughened surface pressed against the plate 7a.
  • the side of the raw-rubber plate 7a upon which the Teflon foil 8a is applied is laid on a not too sharp cutting tool (FIG. 3), upon which tool the round shape is stamped out under high pressure.
  • the Teflon foil 8a'in the first instant takes the pressure without the cutting tool cutting'into it.
  • the rubber plate becomes compressed until the pressure has become so great that the not too sharp circular knife 20 cuts into the Teflon foil 8a (FIG. 3).
  • the circular knife 29 has at this same instant the counteraction of a pressed flat and somewhat radially expanded raw-rubber plate, which after the pressure is relieved ascends again and becomes smaller in diameter, while the stamped-out Teflon disc 8 projects somewhat over the inner diameter of the annular groove 9.
  • the covering disc 7, provided with the Teflon disc 8 is put into a mold 21, 22, whereby the projecting edges of the Teflon disc 8 become bent up by the forming part f that makes the annular groove H65. 4 and 5).
  • the great surface adhesiveness of the former vanishes at the places coming into contact with air, and they may if desired be powdered in knownwise.
  • the anchorage of the covering disc and on occasion an improvement of its sealing action, is obtained by the ridge 7b of the invention, which during the flanging-in becomes clamped laterally against the bottle mouth.
  • This squeezing-in of the pointed runout of the ridge 7b is promoted in that the diameter of the medicine bottle, like all glass objects, has relatively large manufacturing tolerances, so that the flanged cap 4 leaves a certain clearance between it and the outer contour of the bottle mouth 1a, into which clearance parts of the ridge 7b become drawn during the flanging operation, and at the end of the flanging operation they are clamped there with a sealing effect.
  • the clamping attachment is important particularly when a hollow needle is stuck with great force through the sealing disc 3, or when such an operation is done repeatedly by a cannula. It is advantageous in the latter case that'the covering disc 7 consists of an elastomeric material that closes up again after the cannula is removed from the stuck through hole.
  • the covering disc 3 can have a thinning 12 of its wall, to facilitate the sticking-in.
  • the sealing disc blank 7, 8 put into the open mold 21, 22 is dimensioned as respects its part 7, which is for example made of butyl rubber, in such a way that this material, when the mold parts 21, 22 are closed, fills the remaining hollow space, as is shown by a comparison ofFlGS.4and 5.
  • a medicine bottle closure that can be stuck through, with a flanged cap and with a sealing disc which is made of at least two different materials and which is anchored on the front face of the bottle mouth, characterized in that a sealing disc 3 which seals the flat front face 5 of the bottle mouth la, which is made with a bevel-off 6 of its outer rim, consists of a layer, preferably of a Teflon disc 8 or of a similar foil, which covers the bottle opening and approximately half the bottleneck front-face 5 annular area delimited by its outer and inner diameters, and consists of an elastomeric gastight covering disc 7 which covers the bottle opening and the entire front face, upon the middle zone of which disc is applied the Teflon disc 8, and characterized in that this covering disc 7 carries at its outer rim, as an anchorage, a ridge 7b that fits the bevel 6 at the outer rim of the bottle mouth.
  • a closure which can be stuck through, for medicine bottles, in accordance with claim 1, characterized in that the ridge 7b of the covering disc 7 is dimensioned, and preferably made somewhat wedge-shaped, so that after the flanging-in operation it is clamped tightly in position.
  • a closure which can be stuck through, for medicine bottles, in accordance with claim 1, characterized in that the middle zone of the covering disc 7, which carries the Teflon disc 8 or the like, is surrounded by an annular groove 9.
  • a closure which can be stuck through, for medicine bottles, in accordance with claim 4 characterized in that the Teflon disc 8 is drawn somewhat into the interior of the annular groove 9.
  • a process for the production of a sealing disc which consists of at least two different materials and is in accordance with one of the foregoing claims,'and which forms a sealing disc which can be stuck through, for the closure of medicine bottles, characterized in that an elastic raw-rubber plate 7a, consisting of a rubber mixture having in its freshly prepared state an adhesive effect, is covered with a disc 8 of Teflon or similar foil having a roughened surface, and while still in a fresh state it pressed upon or applied upon it the said foil; and characterized in that in a second operation the side of the rawrubber plate to which the Teflon foil is applied is laid in a press upon a circular cutting tool 20 havinga greater diameter than the inner diameter of an annular groove 9 in the covering disc in its finished state, and is pressed under relatively high pressure until the elastic raw-rubber plate 7a is compressed to such an extent that the counterpressure becomes so great that the cutting tool cuts through the Teflon foil and the rawrubber plate, after which, after relief of the pressure, the reas
  • a closure which can be stuck through, for medicine bottles, in accordance with claim 2, characterized in that the middle zone of the covering disc 7, which carries the Teflon disc 8 or the like, is surrounded by an annular groove 9.
  • a closure which can be stuck through, for medicine bottles, in accordance with claim 3, characterized in that the middle zone of the covering disc 7, which carries the Teflon disc 8 or the like, is surrounded by an annular groove 9.
  • a closure adapted to be held in place over the opening in a container by a flanged cap comprising an elastomeric gastight covering disc 7, a layer 8 of Teflon secured to the inner face of said covering disc 7 confronting the container opening, said layer 8 being of a smaller diameter than the inner face of said covering disc 7 so that it completely covers the opening in the container and a portion of the container adjacent the opening therein and means defining an annular groove in the inner face of said elastomeric disc 7 adjacent the outer peripheral edge of said Teflon layer 8, said groove overlying the portion of the container adjacent the opening therein.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
US880483A 1967-11-29 1969-12-10 Pierceable closure for medicine bottles Expired - Lifetime US3552591A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19671566542 DE1566542A1 (de) 1967-11-29 1967-11-29 Durchstechbarer Verschluss fuer Medizinflaschen

Publications (1)

Publication Number Publication Date
US3552591A true US3552591A (en) 1971-01-05

Family

ID=5677999

Family Applications (1)

Application Number Title Priority Date Filing Date
US880483A Expired - Lifetime US3552591A (en) 1967-11-29 1969-12-10 Pierceable closure for medicine bottles

Country Status (10)

Country Link
US (1) US3552591A (enrdf_load_stackoverflow)
AT (1) AT289300B (enrdf_load_stackoverflow)
BE (1) BE724540A (enrdf_load_stackoverflow)
CH (1) CH487775A (enrdf_load_stackoverflow)
DE (1) DE1566542A1 (enrdf_load_stackoverflow)
ES (2) ES143331Y (enrdf_load_stackoverflow)
FR (1) FR1598220A (enrdf_load_stackoverflow)
GB (1) GB1187350A (enrdf_load_stackoverflow)
NL (1) NL6816992A (enrdf_load_stackoverflow)
SE (1) SE353018B (enrdf_load_stackoverflow)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710794A (en) * 1971-06-16 1973-01-16 W Shields Recessed diaphragm with annular grooves for hypodermic syringes
US3760969A (en) * 1970-09-16 1973-09-25 Takeda Chemical Industries Ltd Container closure
JPS49116893U (enrdf_load_stackoverflow) * 1973-01-26 1974-10-05
US4066183A (en) * 1977-02-24 1978-01-03 L. C. Company, Inc. Chromatographic septum having polyimide coating
FR2439143A1 (fr) * 1978-10-20 1980-05-16 Toppan Printing Co Ltd Organe d'obturation pour recipient
US4248355A (en) * 1978-08-04 1981-02-03 Bodenseewerk, Perkin-Elmer & Co., Gmbh Closure for sample vials
DE3231179A1 (de) * 1981-08-24 1983-03-24 Daikyo Gomu Seiko, Ltd., Tokyo Durchstechbares verschlusselement fuer einen behaelter, insbesondere eine medizinflasche
US4397903A (en) * 1979-01-18 1983-08-09 The West Company Molded articles
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers
US4773552A (en) * 1986-11-03 1988-09-27 Bodenseewerk Perkin-Elmer & Co., Gmbh Closure for sample bottles
JPH021275A (ja) * 1988-03-03 1990-01-05 Daikyo Rubber Seiko:Kk 医薬品用プラスチック容器の栓体及びその製造方法
US5061263A (en) * 1989-02-13 1991-10-29 Terumo Kabushiki Kaisha Liquid collection tube
US5130255A (en) * 1990-12-13 1992-07-14 Genentech, Inc. Process for preparing storage stable pharmaceuticals
WO1993004951A1 (en) * 1991-08-28 1993-03-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US5230427A (en) * 1991-06-12 1993-07-27 Ppg Industries, Inc. Sterilizable hermetically-sealed substantially glass container
US6135431A (en) * 1997-12-05 2000-10-24 Drager Sicherheitstechnik Gmbh Scent cartridge
US20010039058A1 (en) * 1999-05-14 2001-11-08 Iheme Mordi I. Fluid transfer device
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US20020187077A1 (en) * 2000-02-02 2002-12-12 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US6558628B1 (en) * 1999-03-05 2003-05-06 Specialty Silicone Products, Inc. Compartment cover, kit and method for forming the same
US20070028704A1 (en) * 2003-09-18 2007-02-08 Ecocap's S.R.L. Glued or heat-sealed cap for resealing test tubes for clinical analyses
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US8460620B2 (en) 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
US8460268B2 (en) 2010-08-22 2013-06-11 Mercy Medical Research Institute Needle safety guard adapted to attach to a liquid container
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211333A (en) * 1978-06-05 1980-07-08 Merck & Co., Inc. Tamperproof container
JPS56119254A (en) * 1980-02-25 1981-09-18 Takeda Chemical Industries Ltd Rubber stopper for vial

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3198368A (en) * 1963-07-24 1965-08-03 Abbott Lab Container closure
US3424329A (en) * 1967-06-21 1969-01-28 Schering Corp Sealed injection vial

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3198368A (en) * 1963-07-24 1965-08-03 Abbott Lab Container closure
US3424329A (en) * 1967-06-21 1969-01-28 Schering Corp Sealed injection vial

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760969A (en) * 1970-09-16 1973-09-25 Takeda Chemical Industries Ltd Container closure
US3710794A (en) * 1971-06-16 1973-01-16 W Shields Recessed diaphragm with annular grooves for hypodermic syringes
JPS49116893U (enrdf_load_stackoverflow) * 1973-01-26 1974-10-05
US4066183A (en) * 1977-02-24 1978-01-03 L. C. Company, Inc. Chromatographic septum having polyimide coating
US4248355A (en) * 1978-08-04 1981-02-03 Bodenseewerk, Perkin-Elmer & Co., Gmbh Closure for sample vials
FR2439143A1 (fr) * 1978-10-20 1980-05-16 Toppan Printing Co Ltd Organe d'obturation pour recipient
US4397903A (en) * 1979-01-18 1983-08-09 The West Company Molded articles
DE3231179A1 (de) * 1981-08-24 1983-03-24 Daikyo Gomu Seiko, Ltd., Tokyo Durchstechbares verschlusselement fuer einen behaelter, insbesondere eine medizinflasche
US4441621A (en) * 1981-08-24 1984-04-10 Takeda Chemical Industries, Ltd. Pierceable closure member for vial
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4773552A (en) * 1986-11-03 1988-09-27 Bodenseewerk Perkin-Elmer & Co., Gmbh Closure for sample bottles
JPH021275A (ja) * 1988-03-03 1990-01-05 Daikyo Rubber Seiko:Kk 医薬品用プラスチック容器の栓体及びその製造方法
JP2582134B2 (ja) 1988-03-03 1997-02-19 株式会社 大協精工 医薬品用プラスチック容器の栓体及びその製造方法
US5061263A (en) * 1989-02-13 1991-10-29 Terumo Kabushiki Kaisha Liquid collection tube
US5130255A (en) * 1990-12-13 1992-07-14 Genentech, Inc. Process for preparing storage stable pharmaceuticals
US5230427A (en) * 1991-06-12 1993-07-27 Ppg Industries, Inc. Sterilizable hermetically-sealed substantially glass container
WO1993004951A1 (en) * 1991-08-28 1993-03-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US5279606A (en) * 1991-08-28 1994-01-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US6135431A (en) * 1997-12-05 2000-10-24 Drager Sicherheitstechnik Gmbh Scent cartridge
US6558628B1 (en) * 1999-03-05 2003-05-06 Specialty Silicone Products, Inc. Compartment cover, kit and method for forming the same
US7927549B2 (en) 1999-05-14 2011-04-19 Gen-Probe Incorporated Method for accessing the contents of a closed collection device with a modified pipette tip
US8334145B2 (en) 1999-05-14 2012-12-18 Gen-Probe Incorporated Pierceable cap having spaced-apart grooves
US8573072B2 (en) 1999-05-14 2013-11-05 Gen-Probe Incorporated Method for removing a fluid substance from a sealed collection device
US20030207463A1 (en) * 1999-05-14 2003-11-06 Iheme Mordi I. Method for obtaining the contents of a fluid-holding vessel
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
US6723289B2 (en) 1999-05-14 2004-04-20 Gen-Probe Incorporated Fluid transfer device
US20040105786A1 (en) * 1999-05-14 2004-06-03 Anderson Bruce W. Collection device
US20040152205A1 (en) * 1999-05-14 2004-08-05 Anderson Bruce W. Method for removing a fluid substance from a collection device
US6806094B2 (en) 1999-05-14 2004-10-19 Gen-Probe Incorporated Method for removing a fluid substance from a collection device
US20050059161A1 (en) * 1999-05-14 2005-03-17 Gen-Probe Incorporated Method for obtaining a fluid sample
US8535621B2 (en) 1999-05-14 2013-09-17 Gen-Probe Incorporated Penetrable cap having rib structures
US8211710B2 (en) 1999-05-14 2012-07-03 Dickey Kathleen A Method for accessing the contents of a closed collection device
US8206662B2 (en) 1999-05-14 2012-06-26 Gen-Probe Incorporated Collection device including a penetrable cap having an absorbent pile fabric
US8038967B2 (en) 1999-05-14 2011-10-18 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US7276383B2 (en) 1999-05-14 2007-10-02 Gen-Probe Incorporated Method for obtaining the contents of a fluid-holding vessel
US20010039058A1 (en) * 1999-05-14 2001-11-08 Iheme Mordi I. Fluid transfer device
US7309469B2 (en) 1999-05-14 2007-12-18 Gen-Probe Incorporated Collection device
US20080047371A1 (en) * 1999-05-14 2008-02-28 Gen-Probe Incorporated Penetrable cap having an absorbent material and method of using the same
US20080118988A1 (en) * 1999-05-14 2008-05-22 Gen-Probe Incorporated Method for accessing the contents of a closed collection device
US20080134808A1 (en) * 1999-05-14 2008-06-12 Gen-Probe Incorporated Method for accessing the contents of a closed collection device with a modified pipette
US20080152545A1 (en) * 1999-05-14 2008-06-26 Gen-Probe Incorporated Assembly containing a specimen retrieval device
US20080245163A1 (en) * 1999-05-14 2008-10-09 Gen-Probe Incorporated Penetrable cap having rib structures
US7435389B2 (en) 1999-05-14 2008-10-14 Gen-Probe Incorporated Sealed collection device having striated cap
US7795036B2 (en) 1999-05-14 2010-09-14 Gen-Probe Incorporated Method for accessing the contents of a closed collection device
US7648680B2 (en) 1999-05-14 2010-01-19 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US6939513B2 (en) * 2000-02-02 2005-09-06 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US20020187077A1 (en) * 2000-02-02 2002-12-12 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US7294308B2 (en) 2001-03-09 2007-11-13 Gen-Probe Incorporated Penetrable cap
US8057762B2 (en) 2001-03-09 2011-11-15 Gen-Probe Incorporated Penetrable cap
US20090208966A1 (en) * 2001-03-09 2009-08-20 Gen-Probe Incorporated Method for removing a fluid substance from a closed system
US7824922B2 (en) 2001-03-09 2010-11-02 Gen-Probe Incorporated Method for removing a fluid substance from a closed system
USRE45194E1 (en) 2001-03-09 2014-10-14 Gen-Probe Incorporated Penetrable cap
US20050079633A1 (en) * 2001-03-09 2005-04-14 Gen-Probe Incorporated Method for transferring a substance to or from a closed system
US8052944B2 (en) 2001-03-09 2011-11-08 Gen-Probe Incorporated Penetrable cap
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US7691332B2 (en) 2001-03-09 2010-04-06 Gen-Probe Incorporated Penetrable cap
US6893612B2 (en) 2001-03-09 2005-05-17 Gen-Probe Incorporated Penetrable cap
US20100190215A1 (en) * 2001-03-09 2010-07-29 Gen-Probe Incorporated Penetrable cap
US8685347B2 (en) 2001-03-09 2014-04-01 Gen-Probe Incorporated Penetrable cap
US7677403B2 (en) * 2003-09-18 2010-03-16 Ecocap's S.R.L. Glued or heat-sealed cap for resealing test tubes for clinical analyses
US20070028704A1 (en) * 2003-09-18 2007-02-08 Ecocap's S.R.L. Glued or heat-sealed cap for resealing test tubes for clinical analyses
US8806920B2 (en) 2008-03-05 2014-08-19 Becton, Dickinson And Company Co-molded pierceable stopper and method for making the same
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly
US8460268B2 (en) 2010-08-22 2013-06-11 Mercy Medical Research Institute Needle safety guard adapted to attach to a liquid container
US9101533B2 (en) 2010-08-22 2015-08-11 Mercy Medical Research Institute Needle safety guard adapted to attach to a liquid container
US8460620B2 (en) 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
US9399218B2 (en) 2010-12-03 2016-07-26 Becton, Dickinson And Company Specimen collection container assembly
US9962704B2 (en) 2010-12-03 2018-05-08 Becton, Dickinson And Company Specimen collection container assembly

Also Published As

Publication number Publication date
SE353018B (enrdf_load_stackoverflow) 1973-01-22
DE1566542A1 (de) 1971-02-18
ES360576A1 (es) 1970-10-16
CH487775A (de) 1970-03-31
ES143331U (es) 1969-03-16
GB1187350A (en) 1970-04-08
AT289300B (de) 1971-02-15
BE724540A (enrdf_load_stackoverflow) 1969-05-02
ES143331Y (es) 1969-11-01
FR1598220A (enrdf_load_stackoverflow) 1970-07-06
NL6816992A (enrdf_load_stackoverflow) 1969-06-02

Similar Documents

Publication Publication Date Title
US3552591A (en) Pierceable closure for medicine bottles
US4981229A (en) Innerseal liner for containers
US3547305A (en) Easy opening container
US4754889A (en) Container and cap
EP0003400A1 (en) Containers
US2783908A (en) Closures for bottles, vials and the like
GB1376775A (en) Package and method of manufacture thereof
WO1979000774A1 (en) Plastic vacuum sealing cap
GB1404995A (en) Pressure release valve for aerosol dispensing cans
US3828963A (en) Recessed crown cap
US2841863A (en) Rubber lined bottle caps
US3122261A (en) Capseals for container closures
US2880900A (en) Expandable diaphragm as a cushion in loose packed bottles
US3734044A (en) Sealed container assembly and method of making same
US2437515A (en) Container closure
JP2607812Y2 (ja) 容器用クロージャ
US3207350A (en) Sealing closure for a crown-type bottle
US3918378A (en) Container closure with vent opening means and method of forming the same
US2665024A (en) Pharmaceutical closure
US3122253A (en) Seal
EP0001690A1 (en) Containers
US1985788A (en) Vacuum-sealing of canister, bottle, jar, and like container
US2979218A (en) Closure cap and sealed package
US2817454A (en) Sealed package
US3799381A (en) Composite closure