US3507278A - Apparatus for dispensing parenteral fluid - Google Patents

Apparatus for dispensing parenteral fluid Download PDF

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US3507278A
US3507278A US648000A US3507278DA US3507278A US 3507278 A US3507278 A US 3507278A US 648000 A US648000 A US 648000A US 3507278D A US3507278D A US 3507278DA US 3507278 A US3507278 A US 3507278A
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valve
reservoir
membrane
casing
cord
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US648000A
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Winfried Joseph Werding
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A61M5/1486—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure the bags being substantially completely surrounded by fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/12—Pressure infusion

Definitions

  • An apparatus for dispensing parenteral fluid is shown consisting of collapsible containers placed in a sealed vessel under pressure.
  • a membrane divides the containers from communication.
  • Rupturing means extending from the vessel are provided for tearing the membrane, thereby allowing communication between the containers.
  • the invention has for its object an apparatus for effecting transfusion characterized mainly by the fact that it comprises a hermetically closed casing in which is placed a flexible collapsible container connected to an external conduit through an outlet valve and a valve mounted on the casing for the introduction of gas under pressure into the casing.
  • the apparatus is of imple design and may be made portable so as to be usable everywhere, in particular at the site of an accident.
  • FIGURE 1 shows in cross-section an apparatus for transfusion according to a first modification.
  • FIGURE 2 shows a partial view of the lower part of the apparatus with the control of the valve for adjusting fiow.
  • FIGURE 3 shows a cross-section of an apparatus for transfusion according to a second modification.
  • FIGURE 4 shows the valve of the apparatus of FIG- URE 3.
  • the apparatus shown on FIGURE 1 comprise a casing 1 of tubular shape made of transparent rigid material, and forming a hermetic enclave inside of which it is possible to introduce a gas, for example compressed air, by a valve 3.
  • a gas for example compressed air
  • Inside casing 1 is positioned a container 4 made of transparent or semi-transparent flexible material secured by its upper extremity 4a to the upper wall 1a of easing 1. This fastening can take place by any suitable means, in particular, by gluing.
  • the lower extremity 4b of the reservoir communicates with the outside of the enclave by a flexible tube 5 connected to a catheter 6 at the extremity of which is secured a hollow needle 7 intended to be introduced in the view or artery of a patient.
  • cap 10 which is generally of a tapered shape extending axially to the casing 1 and serves as a storage space in which the needle and catheter are placed in sterile condition before use.
  • Bolt 9 of the valve has a head 11 (FIG. 2), a portion of which is shaped in the form of an index 11a, movable in front of a scale 12 graduated in hours indicating the time necessary to empty the container 4.
  • position 13 is indexed. This corresponds to a drop-by-drop flow.
  • the apparatus functions in the following manner:
  • the reservoir 4 is first filled with blood or plasma to be injected in the vessels of a patient by the catheter 6. Once the reservoir 4 is full, gate 8 is closed, then there is introduced compressed air through valve 3 in casing 1. By next placing the apparatus in the vertical position shown on the drawing, the catheter is raised to the height of the upper extremity of the casing and gate 8 is opened slightly to permit the escape of all air bubbles which may have formed during the filling of reservoir 4.
  • Next gate 8 is closed and the apparatus is ready to be used.
  • the sterilized needle and catheter are placed in cap 10 and the apparatus can be transported to the place of use, in particular on the site of an accident requiring rapid action.
  • the needle of the catheter is introduced in the vessel of the patient and gate 8 is opened by placing index 11a in front of the graduation corresponding to the flow desired.
  • Reservoir 4 empties then under the action of the pressure of the compressed air contained in casing 1. This pressure has the advantage of being uniformly distributed over the outer surface of reservoir 4.
  • the transparent wall of casing 1 permits constant checking of the quantity of liquid remaining in reservoir 4.
  • the apparatus shown on FIGURE 3 comprises a cylindrical reinforcing casing constituted by an outer metallic envelope 21, covering a cylinder 22 made of transparent or semi-transparent material closed by a disk 27 of similar material.
  • the top of metallic. envelope 21 has a reinforced and threaded portion on which is screwed a cover 28. The tightness of the enclave is ensured by a packing ring 29 compressed between the cover and the edges of cylinder 22.
  • the metallic envelope 21 has a window extending parallel to the axis of the cylinder permitting to check on the state of the reservoir contained in casing 20.
  • the reservoir comprises two chambers 23 and 30 of transparent or semi-transparent fiexible material separated by an impervious membrane 31. Chamber 30 communicates with an external conduit 32 through a valve 33.
  • Conduit 32 comprises a tube the extremity of which 32a can be connected with a catheter, not shown, at the end of which is secured a hollow needle intended to be introduced in the vein or the artery of the patient.
  • the chamber 23 is filled with a physiological solution while chamber 30 is filled with plasma in powder form.
  • Reservoir 23 is first filled with a physiological solution, then a membrane 31 is attached and chamber 30 is then filled with powdered plasma. Before introducing the pressurizing gas, the air contained in chamber 30 is first evacuated as well as that in conduit 32. Then the extremity 32a of the conduit is hermetically sealed. Valve 33 is then closed, and pressurizing gas is introduced in the casing. These operations are carried out with chamber 30 located above chamber 23, in such a way as not to cause the rupture of membrane 31. This membrane is resistant enough to support the pressure of liquid in the position represented in the drawing. As for the pressure due to compressed gas in area 26, the same balances on both sides of the membrane 31. In this manner, the'plasma can be stored for a relatively long time.
  • valve 33 When it is desired to effect a transfusion, valve 33 is first slightly opened which causes a decrease in the pressure in chamber 30 which is in communication with conduit 32. The unbalance of pressure acting on the membrane causes the rupture thereof and thus places into communication chambers 23 and 30. It then sufi'ices to shake the apparatus to bring about the mixing of the Valve 33 is shown in detail on FIGURE 4.
  • This valve comprises a valve body 43 soldered at 35 to metallic cover 29.
  • the lower extremity of body 34 has an inner thread 36 in which screws a socket 37 attached to an index 38. When socket 37 is turned, it closes the jaws of pincers 39 which pinch the supple tube 32 passing through the valve connected to chamber 30.
  • the valve is made air-tight by means of a rubber packing 40 glued to tube 32 and housed in a cylindrical cavity 41 in the body of gate 34.
  • the packing 40 is compressed by means of a nut 42 acting on a washer 43.
  • This apparatus functions satisfactorily when it is placed with its opening down, but when the opening is upwardly inclined, the walls or interior surfaces of the reservoir have the tendency to stick to one another in their upper part under the stress of the pressure of the gas, thus preventing extraction of the liquid from the remainder of the reservoir.
  • the diameter of the cord is selected in proportion to the elasticity of a wall of the reservoir and of the cross section desired for the channels around the cord.
  • cord 50 permits the rupture of the membrane 31 more assuredly than by creating an abrupt unbalance of pressure irrespective of the position of the apparatus. If cord 50 is sealed to the membrane a sudden pull on it will rip membrane 31. If the conduit 32 has a sutlicient elasticity, it is possible to actuate cord 50 by pulling on the conduit itself.
  • Cord 50 may be arranged to extend from conduit 32 so as to be pulled directly.
  • cord 50 permits use of the apparatus with the valve in upward position, which is more practical since it is not necessary to maintain the apparatus in an inverted position relative to the patient. It is thus possible to place the container 20 on the ground.
  • an apparatus for dispensing parenteral fluid, such as plasma, for intravenous feeding comprising a hermetically-sealed vessel under pressure, dual collapsible containers disposed within said vessel and arranged in communicating relation separated by a rupturable membrane, one of said containers being filled with the required ingredient in powder form and the other with a liquid solvent capable of dissolving said powder, an outlet tube in fluid communication with one of said dual collapsible containers, a normally closed valve connected to said vessel and operable to control the opening and closing of said outlet tube, and rupturing means attached to said membrane and extending from said vessel for rupturing said rupturable membrane to effect communication between said containers for dissolving said powder in said liquid.
  • said rupturing means comprises a flexible cord attached to said rupturable membrane wherein said flexible cord extends through said one of said dual collapsible containers and projects into said outlet tube, and wherein said flexible cord is positioned relative to the interior surface of said one of said dual collapsible containers to prevent adhesion thereof.

Description

April 21, 1970 w. J. WERDING I f 3,507,278
APPARATUS FOR DISPENSING PARENTERAL FLUID Filed June 22. 1967 5 Sheets-Sheet 1 April 21, 1970 w. J. WERDING APPARATUS FOR DISPENSINGPAREN'IERAL FLUID s sheets-sheet 5 Filed June 22. 1967 FIGA United States Patent U.S. 128-214 2 Claims ABSTRACT OF THE DISCLOSURE An apparatus for dispensing parenteral fluid is shown consisting of collapsible containers placed in a sealed vessel under pressure. A membrane divides the containers from communication. Rupturing means extending from the vessel are provided for tearing the membrane, thereby allowing communication between the containers.
The techniques of transfusing blood and other parenteral solutions have heretofore required the use of heavy and relatively complicated apparatus by means of which the transfusion took place slowly according to a drop by drop fiow.
It is often necessary to effect such transfusions more rapidly than drop by drop. There is then used an overpressure inside the container containing the liquid to be transfused. It is also possible to use a lift and force pump. This requires constant checking of the liquid level in the reservoir in order to avoid air injection into the blood vessels, an injection of air being liable to occasion death by embolism.
The invention has for its object an apparatus for effecting transfusion characterized mainly by the fact that it comprises a hermetically closed casing in which is placed a flexible collapsible container connected to an external conduit through an outlet valve and a valve mounted on the casing for the introduction of gas under pressure into the casing.
The apparatus is of imple design and may be made portable so as to be usable everywhere, in particular at the site of an accident.
The accompanying drawing represents by way of example two modifications of the device in accordance with the invention.
FIGURE 1 shows in cross-section an apparatus for transfusion according to a first modification.
FIGURE 2 shows a partial view of the lower part of the apparatus with the control of the valve for adjusting fiow.
FIGURE 3 shows a cross-section of an apparatus for transfusion according to a second modification.
FIGURE 4 shows the valve of the apparatus of FIG- URE 3.
The apparatus shown on FIGURE 1 comprise a casing 1 of tubular shape made of transparent rigid material, and forming a hermetic enclave inside of which it is possible to introduce a gas, for example compressed air, by a valve 3. Inside casing 1 is positioned a container 4 made of transparent or semi-transparent flexible material secured by its upper extremity 4a to the upper wall 1a of easing 1. This fastening can take place by any suitable means, in particular, by gluing. The lower extremity 4b of the reservoir communicates with the outside of the enclave by a flexible tube 5 connected to a catheter 6 at the extremity of which is secured a hollow needle 7 intended to be introduced in the view or artery of a patient.
The adjustment of the flow from the container is en- 3,507,278 Patented Apr. 21, 1970 sured by means of a valve 8 consisting of bolt 9 of which the threaded portion 9a is rotatably disposed in block 8. The latter is attached to the end of easing 1. Tube 5 passes through block 8 and the adjustment of flow is effected by screwing or unscrewing rod 8 the extremity of which crushes more or less tube 5.
The assembly is completed by cap 10 which is generally of a tapered shape extending axially to the casing 1 and serves as a storage space in which the needle and catheter are placed in sterile condition before use. Bolt 9 of the valve has a head 11 (FIG. 2), a portion of which is shaped in the form of an index 11a, movable in front of a scale 12 graduated in hours indicating the time necessary to empty the container 4. Near the extreme right-hand position, which is toward the closure of the tube, position 13 is indexed. This corresponds to a drop-by-drop flow.
The apparatus functions in the following manner:
The reservoir 4 is first filled with blood or plasma to be injected in the vessels of a patient by the catheter 6. Once the reservoir 4 is full, gate 8 is closed, then there is introduced compressed air through valve 3 in casing 1. By next placing the apparatus in the vertical position shown on the drawing, the catheter is raised to the height of the upper extremity of the casing and gate 8 is opened slightly to permit the escape of all air bubbles which may have formed during the filling of reservoir 4.
Next gate 8 is closed and the apparatus is ready to be used. The sterilized needle and catheter are placed in cap 10 and the apparatus can be transported to the place of use, in particular on the site of an accident requiring rapid action.
During use, the needle of the catheter is introduced in the vessel of the patient and gate 8 is opened by placing index 11a in front of the graduation corresponding to the flow desired. Reservoir 4 empties then under the action of the pressure of the compressed air contained in casing 1. This pressure has the advantage of being uniformly distributed over the outer surface of reservoir 4. The transparent wall of casing 1 permits constant checking of the quantity of liquid remaining in reservoir 4.
In connection with the transfusion of blood plasma, it has proven advisable, for reasons of preserving the plasma, to keep it separately in the form of a powder, and mixing it in the physiological liquid immediately before use.
The apparatus shown in FIGURES 3 and 4 will serve this purpose.
The apparatus shown on FIGURE 3 comprises a cylindrical reinforcing casing constituted by an outer metallic envelope 21, covering a cylinder 22 made of transparent or semi-transparent material closed by a disk 27 of similar material. The top of metallic. envelope 21 has a reinforced and threaded portion on which is screwed a cover 28. The tightness of the enclave is ensured by a packing ring 29 compressed between the cover and the edges of cylinder 22. The metallic envelope 21 has a window extending parallel to the axis of the cylinder permitting to check on the state of the reservoir contained in casing 20. The reservoir comprises two chambers 23 and 30 of transparent or semi-transparent fiexible material separated by an impervious membrane 31. Chamber 30 communicates with an external conduit 32 through a valve 33. Conduit 32 comprises a tube the extremity of which 32a can be connected with a catheter, not shown, at the end of which is secured a hollow needle intended to be introduced in the vein or the artery of the patient.
In the condition shown on FIGURE 3, the chamber 23 is filled with a physiological solution while chamber 30 is filled with plasma in powder form.
Reservoir 23 is first filled with a physiological solution, then a membrane 31 is attached and chamber 30 is then filled with powdered plasma. Before introducing the pressurizing gas, the air contained in chamber 30 is first evacuated as well as that in conduit 32. Then the extremity 32a of the conduit is hermetically sealed. Valve 33 is then closed, and pressurizing gas is introduced in the casing. These operations are carried out with chamber 30 located above chamber 23, in such a way as not to cause the rupture of membrane 31. This membrane is resistant enough to support the pressure of liquid in the position represented in the drawing. As for the pressure due to compressed gas in area 26, the same balances on both sides of the membrane 31. In this manner, the'plasma can be stored for a relatively long time.
When it is desired to effect a transfusion, valve 33 is first slightly opened which causes a decrease in the pressure in chamber 30 which is in communication with conduit 32. The unbalance of pressure acting on the membrane causes the rupture thereof and thus places into communication chambers 23 and 30. It then sufi'ices to shake the apparatus to bring about the mixing of the Valve 33 is shown in detail on FIGURE 4. This valve comprises a valve body 43 soldered at 35 to metallic cover 29. The lower extremity of body 34 has an inner thread 36 in which screws a socket 37 attached to an index 38. When socket 37 is turned, it closes the jaws of pincers 39 which pinch the supple tube 32 passing through the valve connected to chamber 30. The valve is made air-tight by means of a rubber packing 40 glued to tube 32 and housed in a cylindrical cavity 41 in the body of gate 34. The packing 40 is compressed by means of a nut 42 acting on a washer 43.
This apparatus functions satisfactorily when it is placed with its opening down, but when the opening is upwardly inclined, the walls or interior surfaces of the reservoir have the tendency to stick to one another in their upper part under the stress of the pressure of the gas, thus preventing extraction of the liquid from the remainder of the reservoir.
It is possible to avoid this by using a wire or cord 59 passing through the valve and maintained in place by it and which extends into the flexible reservoir in such a way as to prevent sticking together of the walls of the reservoir near the wire. This cord is preferably made of catgut or nylon.
The diameter of the cord is selected in proportion to the elasticity of a wall of the reservoir and of the cross section desired for the channels around the cord.
The presence of cord 50 permits the rupture of the membrane 31 more assuredly than by creating an abrupt unbalance of pressure irrespective of the position of the apparatus. If cord 50 is sealed to the membrane a sudden pull on it will rip membrane 31. If the conduit 32 has a sutlicient elasticity, it is possible to actuate cord 50 by pulling on the conduit itself.
Cord 50 may be arranged to extend from conduit 32 so as to be pulled directly.
The presence of the cord 50 permits use of the apparatus with the valve in upward position, which is more practical since it is not necessary to maintain the apparatus in an inverted position relative to the patient. It is thus possible to place the container 20 on the ground.
What is claimed is:
1. In an apparatus for dispensing parenteral fluid, such as plasma, for intravenous feeding: comprising a hermetically-sealed vessel under pressure, dual collapsible containers disposed within said vessel and arranged in communicating relation separated by a rupturable membrane, one of said containers being filled with the required ingredient in powder form and the other with a liquid solvent capable of dissolving said powder, an outlet tube in fluid communication with one of said dual collapsible containers, a normally closed valve connected to said vessel and operable to control the opening and closing of said outlet tube, and rupturing means attached to said membrane and extending from said vessel for rupturing said rupturable membrane to effect communication between said containers for dissolving said powder in said liquid.
2. Apparatus in accordance with claim 1 wherein said rupturing means comprises a flexible cord attached to said rupturable membrane wherein said flexible cord extends through said one of said dual collapsible containers and projects into said outlet tube, and wherein said flexible cord is positioned relative to the interior surface of said one of said dual collapsible containers to prevent adhesion thereof.
References Cited UNITED STATES PATENTS 2,663,298 12/1953 Rose 128-214 2,744,527 5/1956 Barrett et al 128-216 2,842,123 7/1958 Rundhaug 12s 214 2,876,768 3/1959 Schultz 128-214 3,048,171 8/1962 Grau 128-2142 3,294,227 12/1966 Schneider et al. 206-47 3,375,824 4/1968 Krakauer et al. 128-214 FOREIGN PATENTS 61,592 11/1954 France.
DALTON L. TRULUCK, Primary Examiner U.S. Cl. X.R.
US648000A 1966-06-27 1967-06-22 Apparatus for dispensing parenteral fluid Expired - Lifetime US3507278A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH927966A CH461034A (en) 1966-06-27 1966-06-27 Transfusion device
CH1224166A CH470185A (en) 1966-06-27 1966-08-24 Transfusion device
CH822367A CH484678A (en) 1966-06-27 1967-06-09 Transfusion device

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JP (1) JPS4825999B1 (en)
BE (1) BE700553A (en)
BR (1) BR6790846D0 (en)
CH (3) CH461034A (en)
DE (1) DE1566677A1 (en)
ES (1) ES342302A1 (en)
GB (1) GB1188168A (en)
NL (1) NL6708952A (en)
NO (1) NO117875B (en)
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Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790118A (en) * 1972-03-01 1974-02-05 C Warren Douche bag holder
US3939832A (en) * 1973-03-09 1976-02-24 Med-Pak Corporation Liquid flow regulator and monitor for infusion system
DE2536746A1 (en) * 1974-08-16 1976-03-04 Health Technology Lab DEVICE FOR SUCTION OF LIQUID
US4215476A (en) * 1977-03-25 1980-08-05 Armstrong Alexander S Health services combination irrigator and aspirator
US4237881A (en) * 1978-12-26 1980-12-09 Anatros Corporation Device for the intravenous or enteric infusion of liquids into the human body at a predetermined constant rate
DE2922957A1 (en) * 1979-06-06 1980-12-18 Mottaghy Khosrow METHOD AND DEVICE FOR CIRCULATING OR PUMPS OF ORGANIC-BIOLOGICAL LIQUIDS, ESPECIALLY BLOOD
WO1981002982A1 (en) * 1980-04-22 1981-10-29 Key Pharma Inhalation spirometric device for administering pulmonary medication
US4312493A (en) * 1979-05-05 1982-01-26 Stauffer Rita A Apparatus for controlled liquid administration
US4318400A (en) * 1980-01-18 1982-03-09 Alza Corporation Medical infusor
DE3120047A1 (en) * 1981-05-20 1982-12-16 Härle, Anton, Dr., 4400 Münster Suction device for taking up and emitting, e.g. for removing, medical secretions or fluids
US4386929A (en) * 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US5192272A (en) * 1989-10-26 1993-03-09 Faure Jean Marie Pack for administration of sterile liquids including pharmaceutical, nutrient and energy-source liquids
DE4201992A1 (en) * 1992-01-25 1993-07-29 Hp Medica Gmbh Fuer Medizintec HIGH PRESSURE LIQUID DISPENSOR FOR DISPENSING STERILE LIQUID
US5348539A (en) * 1993-06-29 1994-09-20 Glenn Herskowitz Infusion pump for use with prepackaged IV bags
US5578001A (en) * 1994-09-13 1996-11-26 Shah; Pranav N. Infusion apparatus for IV bags
US5954696A (en) * 1997-12-15 1999-09-21 B. Braun Medical, Inc. Pressure infusion pump
US5957895A (en) * 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6056724A (en) * 1997-01-06 2000-05-02 Medex Device for injection of medical liquid
US6096007A (en) * 1997-08-01 2000-08-01 Storz Endoskop Gmbh Pressure container for applying pressure to a flexible bag received in it and filled with a medical fluid
US20040024412A1 (en) * 2002-08-05 2004-02-05 Clements Don A. Apparatus for delivery of fluid to ophthalmic surgical handpiece
FR2844705A1 (en) * 2002-09-25 2004-03-26 Medex Sa Supple pouch for liquid medication has fastenings for attaching to injection system support
WO2004050534A2 (en) * 2002-12-02 2004-06-17 Curatio Aps Fluid dispenser
US20050171477A1 (en) * 2002-05-23 2005-08-04 Seedlings Life Science Ventures Apparatus and method for rapid auto-injection of medication
US20070131711A1 (en) * 2005-12-12 2007-06-14 Carrier Corporation Concentrate holder
US20070250008A1 (en) * 2006-04-20 2007-10-25 Gelblum Eugene A Fluid injection apparatus and adaptor pump therefor
CN102049074A (en) * 2011-01-28 2011-05-11 中国人民解放军第二军医大学 Controllable constant-pressure infusion device
US20110142885A1 (en) * 2009-09-16 2011-06-16 Velico Medical, Inc. Spray-dried human plasma
US8407912B2 (en) 2010-09-16 2013-04-02 Velico Medical, Inc. Spray dried human plasma
US8533971B2 (en) 2010-10-29 2013-09-17 Velico Medical, Inc. System and method for spray drying a liquid
US9498570B2 (en) 2010-10-25 2016-11-22 Bayer Healthcare Llc Bladder syringe fluid delivery system
US9814871B2 (en) 2013-03-15 2017-11-14 Bayer Healthcare Llc Connector assembly for syringe system
US9867782B2 (en) 2009-04-09 2018-01-16 Entegrion, Inc. Spray-dried blood products and methods of making same
US10046106B2 (en) 2010-10-25 2018-08-14 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10105491B2 (en) 2012-04-20 2018-10-23 Bayer Healthcare Llc Collapsible syringe for fluid delivery system
CN110141720A (en) * 2019-06-21 2019-08-20 青岛大学附属医院 A kind of operating room transfusion bags heat-insulating pressurizing device
US20200093999A1 (en) * 2018-09-26 2020-03-26 Erbe Elektromedizin Gmbh Medical Instrument and Generation Device
US10843100B2 (en) 2010-10-29 2020-11-24 Velico Medical, Inc. Spray drier assembly for automated spray drying
US11052045B2 (en) 2014-09-19 2021-07-06 Velico Medical, Inc. Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage
US11083882B2 (en) 2015-11-25 2021-08-10 Bayer Healthcare Llc Syringe and connector system
US11839751B2 (en) 2020-06-18 2023-12-12 Bayer Healthcare Llc In-line air bubble suspension apparatus for angiography injector fluid paths
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US11938093B2 (en) 2020-02-21 2024-03-26 Bayer Healthcare Llc Fluid path connectors for medical fluid delivery

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3218561C2 (en) * 1982-05-17 1988-08-18 Günter H. Dr.-Ing. 8035 Gauting Marx Device for taking up and reinfusing blood
EP0098893B1 (en) * 1982-07-15 1987-10-07 Ferring Biotechnik GmbH Device for administering liquid medicaments

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2663298A (en) * 1950-06-16 1953-12-22 Hilton W Rose Apparatus and method for administering parenteral solutions
FR61592E (en) * 1951-04-19 1955-05-12 Method of using elastic sheath tubes for fluid or pasty products
US2744527A (en) * 1952-04-21 1956-05-08 Barrett Altina Syringes and syringe mixers
US2842123A (en) * 1956-05-25 1958-07-08 Le Roy M Rundhaug Pressurized transfusion apparatus
US2876768A (en) * 1952-12-26 1959-03-10 Howard C Schultz Pressure-vacuum clysis unit
US3048171A (en) * 1958-11-03 1962-08-07 Bio Physical Res Inc Intravenous injection device
US3294227A (en) * 1965-03-05 1966-12-27 Wayne Rodgers V Multiple compartment package
US3375824A (en) * 1965-07-08 1968-04-02 Air Force Usa Self-contained plasma administration pack

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2663298A (en) * 1950-06-16 1953-12-22 Hilton W Rose Apparatus and method for administering parenteral solutions
FR61592E (en) * 1951-04-19 1955-05-12 Method of using elastic sheath tubes for fluid or pasty products
US2744527A (en) * 1952-04-21 1956-05-08 Barrett Altina Syringes and syringe mixers
US2876768A (en) * 1952-12-26 1959-03-10 Howard C Schultz Pressure-vacuum clysis unit
US2842123A (en) * 1956-05-25 1958-07-08 Le Roy M Rundhaug Pressurized transfusion apparatus
US3048171A (en) * 1958-11-03 1962-08-07 Bio Physical Res Inc Intravenous injection device
US3294227A (en) * 1965-03-05 1966-12-27 Wayne Rodgers V Multiple compartment package
US3375824A (en) * 1965-07-08 1968-04-02 Air Force Usa Self-contained plasma administration pack

Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790118A (en) * 1972-03-01 1974-02-05 C Warren Douche bag holder
US3939832A (en) * 1973-03-09 1976-02-24 Med-Pak Corporation Liquid flow regulator and monitor for infusion system
DE2536746A1 (en) * 1974-08-16 1976-03-04 Health Technology Lab DEVICE FOR SUCTION OF LIQUID
US4215476A (en) * 1977-03-25 1980-08-05 Armstrong Alexander S Health services combination irrigator and aspirator
US4237881A (en) * 1978-12-26 1980-12-09 Anatros Corporation Device for the intravenous or enteric infusion of liquids into the human body at a predetermined constant rate
US4312493A (en) * 1979-05-05 1982-01-26 Stauffer Rita A Apparatus for controlled liquid administration
DE2922957A1 (en) * 1979-06-06 1980-12-18 Mottaghy Khosrow METHOD AND DEVICE FOR CIRCULATING OR PUMPS OF ORGANIC-BIOLOGICAL LIQUIDS, ESPECIALLY BLOOD
US4318400A (en) * 1980-01-18 1982-03-09 Alza Corporation Medical infusor
US4386929A (en) * 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
WO1981002982A1 (en) * 1980-04-22 1981-10-29 Key Pharma Inhalation spirometric device for administering pulmonary medication
DE3120047A1 (en) * 1981-05-20 1982-12-16 Härle, Anton, Dr., 4400 Münster Suction device for taking up and emitting, e.g. for removing, medical secretions or fluids
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US5192272A (en) * 1989-10-26 1993-03-09 Faure Jean Marie Pack for administration of sterile liquids including pharmaceutical, nutrient and energy-source liquids
DE4201992A1 (en) * 1992-01-25 1993-07-29 Hp Medica Gmbh Fuer Medizintec HIGH PRESSURE LIQUID DISPENSOR FOR DISPENSING STERILE LIQUID
US5259842A (en) * 1992-01-25 1993-11-09 Hp-Media Gesellschaft Mgh Fur Medizintechnische Systeme High-pressure liquid dispenser for the dispensing of sterile liquid
US5348539A (en) * 1993-06-29 1994-09-20 Glenn Herskowitz Infusion pump for use with prepackaged IV bags
US5578001A (en) * 1994-09-13 1996-11-26 Shah; Pranav N. Infusion apparatus for IV bags
US6056724A (en) * 1997-01-06 2000-05-02 Medex Device for injection of medical liquid
US6096007A (en) * 1997-08-01 2000-08-01 Storz Endoskop Gmbh Pressure container for applying pressure to a flexible bag received in it and filled with a medical fluid
US5954696A (en) * 1997-12-15 1999-09-21 B. Braun Medical, Inc. Pressure infusion pump
US5957895A (en) * 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US20050171477A1 (en) * 2002-05-23 2005-08-04 Seedlings Life Science Ventures Apparatus and method for rapid auto-injection of medication
US7658724B2 (en) 2002-05-23 2010-02-09 Seedings Life Science Ventures LLC Apparatus and method for rapid auto-injection of medication
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US20040024412A1 (en) * 2002-08-05 2004-02-05 Clements Don A. Apparatus for delivery of fluid to ophthalmic surgical handpiece
US6921385B2 (en) * 2002-08-05 2005-07-26 Alcon, Inc. Apparatus for delivery of fluid to opthalmic surgical handpiece
WO2004028597A3 (en) * 2002-09-25 2004-05-06 Medex Sa Flexible bag and associated injection device
WO2004028597A2 (en) * 2002-09-25 2004-04-08 Medex Flexible bag and associated injection device
FR2844705A1 (en) * 2002-09-25 2004-03-26 Medex Sa Supple pouch for liquid medication has fastenings for attaching to injection system support
WO2004050534A2 (en) * 2002-12-02 2004-06-17 Curatio Aps Fluid dispenser
WO2004050534A3 (en) * 2002-12-02 2004-08-19 Curatio Aps Fluid dispenser
US20070131711A1 (en) * 2005-12-12 2007-06-14 Carrier Corporation Concentrate holder
US8905267B2 (en) * 2005-12-12 2014-12-09 Carrier Corporation Concentrate holder
US20070250008A1 (en) * 2006-04-20 2007-10-25 Gelblum Eugene A Fluid injection apparatus and adaptor pump therefor
US11213488B2 (en) 2009-04-09 2022-01-04 Entegrion, Inc. Spray-dried blood products and methods of making same
US9867782B2 (en) 2009-04-09 2018-01-16 Entegrion, Inc. Spray-dried blood products and methods of making same
US10251911B2 (en) 2009-09-16 2019-04-09 Entegrion, Inc. Spray dried human plasma
US20110142885A1 (en) * 2009-09-16 2011-06-16 Velico Medical, Inc. Spray-dried human plasma
US8407912B2 (en) 2010-09-16 2013-04-02 Velico Medical, Inc. Spray dried human plasma
US8434242B2 (en) 2010-09-16 2013-05-07 Velico Medical, Inc. Spray dried human plasma
US9498570B2 (en) 2010-10-25 2016-11-22 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10835680B2 (en) 2010-10-25 2020-11-17 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10046106B2 (en) 2010-10-25 2018-08-14 Bayer Healthcare Llc Bladder syringe fluid delivery system
US8601712B2 (en) 2010-10-29 2013-12-10 Velico Medical, Inc. System and method for spray drying a liquid
US8533971B2 (en) 2010-10-29 2013-09-17 Velico Medical, Inc. System and method for spray drying a liquid
US8595950B2 (en) * 2010-10-29 2013-12-03 Velico Medical, Inc. System and method for spray drying a liquid
US8533972B2 (en) 2010-10-29 2013-09-17 Velico Medical, Inc. System and method for spray drying a liquid
US10843100B2 (en) 2010-10-29 2020-11-24 Velico Medical, Inc. Spray drier assembly for automated spray drying
CN102049074A (en) * 2011-01-28 2011-05-11 中国人民解放军第二军医大学 Controllable constant-pressure infusion device
CN102049074B (en) * 2011-01-28 2012-07-11 中国人民解放军第二军医大学 Controllable constant-pressure infusion device
US10105491B2 (en) 2012-04-20 2018-10-23 Bayer Healthcare Llc Collapsible syringe for fluid delivery system
US9814871B2 (en) 2013-03-15 2017-11-14 Bayer Healthcare Llc Connector assembly for syringe system
US11052045B2 (en) 2014-09-19 2021-07-06 Velico Medical, Inc. Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage
US11806431B2 (en) 2014-09-19 2023-11-07 Velico Medical, Inc. Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage
US11083882B2 (en) 2015-11-25 2021-08-10 Bayer Healthcare Llc Syringe and connector system
CN110946641A (en) * 2018-09-26 2020-04-03 厄比电子医学有限责任公司 Medical instrument and generating device
US20200093999A1 (en) * 2018-09-26 2020-03-26 Erbe Elektromedizin Gmbh Medical Instrument and Generation Device
US11918733B2 (en) * 2018-09-26 2024-03-05 Erbe Elektromedizin Gmbh Medical instrument and aerosol generation device
CN110946641B (en) * 2018-09-26 2023-08-29 厄比电子医学有限责任公司 Medical instrument and generating device
CN110141720A (en) * 2019-06-21 2019-08-20 青岛大学附属医院 A kind of operating room transfusion bags heat-insulating pressurizing device
US11938093B2 (en) 2020-02-21 2024-03-26 Bayer Healthcare Llc Fluid path connectors for medical fluid delivery
US11839751B2 (en) 2020-06-18 2023-12-12 Bayer Healthcare Llc In-line air bubble suspension apparatus for angiography injector fluid paths
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US11913723B1 (en) 2022-09-15 2024-02-27 Velico Medical, Inc. Baffle plate used in a disposable for a spray drying system
US11913722B1 (en) 2022-09-15 2024-02-27 Velico Medical, Inc. Rapid spray drying system

Also Published As

Publication number Publication date
CH461034A (en) 1968-08-15
BE700553A (en) 1967-12-01
NO117875B (en) 1969-10-06
JPS4825999B1 (en) 1973-08-03
DE1566677A1 (en) 1970-02-12
NL6708952A (en) 1967-12-28
CH470185A (en) 1969-03-31
CH484678A (en) 1970-01-31
GB1188168A (en) 1970-04-15
ES342302A1 (en) 1968-10-01
OA02457A (en) 1970-05-05
SE338404B (en) 1971-09-06
BR6790846D0 (en) 1973-04-19

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