US2787268A - Blood plasma bottle - Google Patents

Blood plasma bottle Download PDF

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Publication number
US2787268A
US2787268A US57203556A US2787268A US 2787268 A US2787268 A US 2787268A US 57203556 A US57203556 A US 57203556A US 2787268 A US2787268 A US 2787268A
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United States
Prior art keywords
plug
bottle
cap
plasma
container
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Expired - Lifetime
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Greenspan Irving
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Greenspan Irving
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2031Separating means having openings brought into alignment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/08Mixing

Description

April 2, 1957 1. GREENSPAN BLOOD PLASMA BOTTLE Filed March 16, 1956 garner/575 M @merza affawvze gxa United States Patent BLOOD PLASMA BOTTLE Irving Greenspan, Skokie, Ill.

Application March 16, 1956, Serial No. 572,035

9 Claims. (Cl. 128-272) This invention relates generally to a container for perishable materials and more particularly is concerned with the construction of a container for blood plasma which is adapted to be used for direct application quickly and without difficulty.

Blood plasma is usually dried, and mixed with water just prior to administration, and considerable difliculty has accompanied the use of the containers which are known, especially for field application. The plasma is perishable, and hence it and a container of water are furnished as two separate parts of a kit. The plasma is in powdered form and packed in vacuum and the water is sterile. The attendant is furnished with a double ended hollow needle. One end must first be inserted into the water bottle cap, and the water bottle is then picked up and the opposite end of the needle inserted into the plasma bottle so that the vacuum in the plasma bottle draws the water through the hollow needle and into contact with the dried plasma to become hydrated. Thereafter, the water bottle is removed and a tube with administering end is attached to the needle now protruding from the plasma bottle. The liquid then flows either by gravity, or through the use of a pump fitted to the administering tube, to the blood vessel of the patient.

The difficulties attendant upon the use of the kit described are manifold:

1. In haste, often the needle will first be inserted into the plasma bottle, whereupon the vacuum is lost and there is no sterile way of admixing the dried plasma and water, and even if there were some way of introducing the water into the plasma bottle, the air sucked in when the vacuum is broken may well have contaminated the plasma. Thus there has been in the past tremendous waste due to errors of personnel and this had been particularly serious in combat, where the attendant may not have much skill along these lines.

2. Bottle breakage is a cause of considerable loss.

3. The kit contains two bottles, and hence is heavy and takes up considerable space.

4. In forced administration, the pump must be fitted to the administering tube and operated continuously by the attendant because small size of the conduit in the needle limits the rate of flow.

This invention alleviates and eliminates the disadvantages of previous methods of administering blood plasma and the principal object of the invention is directed to provision of a structure for a plasma bottle which will eliminate and positively prevent the error of puncturing the wrong bottle with its attendant waste; the provision of a structure which is unbreakable; the provision of a structure for a plasma bottle which is a single unit, light in weight and of small volume; the provision of a plasma bottle with which plasma may be forcibly administered without the need for pumps or other fittings.

Many other objects of the invention will appear as the description proceeds in connection with which I have illustrated a preferred embodiment from an examination ice of which, in connection with the explanation, the invention should be fully understood and appreciated.

In the drawing:

Fig. 1 is a side elevational view of a plasma bottle constructed in accordance with the invention.

Fig. 2 is a sectional view taken through the same along its axis.

3 is a sectional view through the plug of the bottle on an enlarged scale.

Fig. 4 is a fragmentary sectional view through the bottle showing same during use.

Generally, the invention consists of a bottle of some flexible material, such as polyethylene, having two compartments, separated by a wall which is normally plugged during transportation of the bottle. The dried plasma is in one compartment, and sterile water in the other, if desired. The plasma compartment is unplugged when it is desired to use the same, and the plug becomes the cap for the bottle, such that when inverted the needle of the administering tube may be inserted through the plug into the bottle. After unplugging the plasma compartment and closing off the end of the bottle, the bottle is shaken to dissolve the plasma. When forced feeding is desired, the bottle is squeezed and its collapse increases the pressure of the flow of plasma.

Referring now to the drawing, the bottle is designated by the reference character 10, and it will be seen that same is formed in any conventional shape, such as for example, having a cylindrical configuration providing cylindrical side wall 12 with a bottom wall 14 closing off the bottle, and an upper neck 16 having an internally threaded mouth 18 adapted to be closed off by a cap 2t) with a male threaded portion 22. The bottle has a central diaphragm or wall 24 provided with a central reenforced threaded opening 26 coaxial with the mouth 18 and preferably of smaller diameter.

The wall 24 thus forms the interior of the bottle 10 into two compartments, the upper or water compartment 28 and the lower or plasma compartment 30. Obviously when used, as in Fig. 4, the compartments are inverted.

The cap 22 has a depending rod 32 of some inert material such as plastic, which telescopically engages with another rod 34 at the bottom of which is fastened a plug 36. If desired, a slot and pin connection may be provided to prevent separation of rods 32 and 34, but relatively tight frictional engagement is suflicient. The configuration of the telescoping members 32 and 34 is such that rotation of the cap 20 imparts rotation to the plug 36, irrespective of the positions of the cap and plug one relative the other. The plug 36 has an upper threaded part 38 which is of a size to engage with the threads of the mouth 18, and a lower threaded part 40 which is of a size to threadedly engage with the threads of the opening 26. The rod 34 is frictionally engaged in a suitable recess 42 in the plug 36 and the upper end of the rod 32 is fixed to the cap 20. There is a diaphragm 44 in the plug 36 to enable a needle 46 on the end of an administering tube 48 to be inserted therein as shown in Fig. 4 when the bottle 10 is used.

The bottle 10 is preferably formed of polyethylene or similar flexible resilient material, and while shown as an integral structure may be composite, that is-made up of two parts welded or cemented together to eliminate the need for complicated moulding procedures or coring. Any suitable means for supporting the bottle 10 inverted may be used, such as for example, a tape 50 secured to the side of the bottle by cement or the like provided with a grommet 52 or the like.

In filling the bottle, first the dried plasma. is disposed in the compartment 30. The assembled plug 36, cap 20 and the connecting rods 32 and 34, is then manipulated so that the plug 36 is screwed through the mouth 18,

Patented Apr. 2, 1957 greases after which the plug is lowered and part as is tightly screwed into the threaded opening as, thereby closing off the plasma in the lower compartment. Thereafter water may be introduced into the compartment 28 by any suitable means, and the cap 2% tightly screwed home. This process may readily be done under sterile conditions in the manufacturing laboratory, and if required, the completed package may be subjected to heat for sterilizing purposes. The upper compartment may be left empty if facilities to provide sterile water available at the place of use.

,In use, the bottle is prepared by first unscrewing the cap 20. While this is being done, the plug 36 is being removed from the opening 26. The plug is thereafter lifted and screwed into the mouth 18 from the bottom thereof, as shown in Fig. 4. The cap 12 and rods 32; and 34 are then pulled away from the plug 36. The bottle it) may then be shaken to dissolve all of the plasma. Thereafter it is inverted into position, the needle 45 inserted into the diaphragm 44 and the plasma immediately flows through the tube 48 to the patient. If pressure is desired, the attendant merely grasps the bottle 1d and squeezes the same and forces the liquid plasma through the tube 48. Any suitable valve arrangement may be used to admit air into the bottle as the liquid 54 is emptied.

Obviously where the bottle MD is made of an inflexible material, all of the advantages of the invention accrue with the exception of the advantage of being able to apply force by merely squeezing the bottle.

It is believed that the invention has sui'liciently been described to enable an understanding thereof, but it is desired to point out that considerable variation is possible without departing from the spirit and scope thereof as defined in the appended claims.

I claim:

1. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, the plug having a needle receiving diaphragm whereby to enable piercing of the diaphragm and communication with the interior of the container through the needle.

2. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, at least the second compartment being formed of flexible material whereby to enable the manual compression to decrease the volume of the container.

3. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be ms ulatcd "to cause engagement of the plug with the ope-.nng, the and cap both being screw threaded, and the passageway and opening also being screw threaded, and the connecting means being a member having the plug and cap non-rotatively secured thereto.

4. A container for storing and administering plasma, which comprises a composite member having two compartmenis, an opening in one compartment for gaining access to the interior thereof from the exterior or" the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, the plug and cap both being screw threaded, and the passageway and opening also being screw threaded, and the connecting means being a member having the plug and cap non-rotatively secured thereto, but axially movable relative one another.

5. A container as claimed in claim 3 in which the plug has two axially arranged parts, one part being screw threaded and having a smaller diameter than the screw thread of the opening but of a size to engage the screw thread of the passageway, and the second part being screw threaded and having a diameter to engage the screw thread of the opening.

6. A container for storing and administering blood plasma through a hollow administering needle, comprising a composite member having an inner and an outer compartment, the outer compartment adapted to contain water and having a cap thereon, a passageway between the compartments and a plug engaged in the passageway and closing same off, the first compartment adapted to have dried plasma therein, a means connected between the plug and cap and arranged to cause simultaneous rotation of plug and cap, and the plug being constructed to fit into the opening, so that the cap may be removed and will simultaneously remove the plug from the passageway, and said cap can further be moved to drive the plug into the opening to seal off the container but provide access between the compartments thereof.

7. A container as claimed in claim 6 in which the plug has a needle receiving diaphragm adapted to be pierced for draining liquid from the container through the needle.

8. A container as claimed in claim 6 in which there is screw-threaded engagement between the cap and opening, and between the plug and passageway, and when the cap is moved to drive the plug into the opening there is screw-threaded engagement between the plug and opening.

9. A container as claimed in claim 6 in which the means between the cap and plug is formed of at least two telescopically engaged members non-rotative one relative the other, but axially movable one relative the other.

References Cited in the file of this patent UNITED STATES PATENTS 1,275,315 Smith Aug. 13, 1918 1,413,703 Biehn Apr. 25, 1922 2,419,453 Kocevar Apr. 22, 1947 2,447,166 Daffer Aug. 17, 1948 2,693,189 Ryan NOV. 2, 1954

US57203556 1956-03-16 1956-03-16 Blood plasma bottle Expired - Lifetime US2787268A (en)

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3070093A (en) * 1959-02-25 1962-12-25 Stanley J Sarnoff Medicament and diluent storing, mixing, and dispensing device
US3161310A (en) * 1960-10-14 1964-12-15 Baxter Don Inc Parenteral solution container
US4024952A (en) * 1974-10-03 1977-05-24 Koninklijke Emballage Industrie Van Leer B.V. Screw cap for a container
WO1984001355A1 (en) * 1982-09-28 1984-04-12 Scholten Bent Henrik Niels Von An aerosol container or similar dispensing device for discharging pressurized liquids
US4453636A (en) * 1983-05-03 1984-06-12 Meadows Bernard A Safe container
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
US4836370A (en) * 1986-02-03 1989-06-06 Steigmuhle Toss Ag Dual chamber container and method for forming an opening between the chambers of the container
US5088627A (en) * 1990-07-25 1992-02-18 Wheaton Industries Multi-chamber package for mixing and dispensing
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5447226A (en) * 1992-06-09 1995-09-05 Societe De Conseils Et D'eutdes Des Emballages (S.C.E.E.) Dual compartment container with means for mixing and dispensing a product
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US5893452A (en) * 1996-02-15 1999-04-13 L'oreal Monopiece body for the separate packaging and mixing of at least two products
US6001643A (en) * 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
US6022134A (en) * 1996-10-25 2000-02-08 Rxi Plastics, Inc. Mixing and dispensing container
US20030026164A1 (en) * 2001-08-02 2003-02-06 Klein Arnold Gregory Convenience nectar mixing and storage devices
US20050111300A1 (en) * 2003-10-01 2005-05-26 Berthold Nies Device for the mixing and discharge of liquid and pulverulent materials for medical use
US20060153000A1 (en) * 2001-08-02 2006-07-13 Klein Arnold G Convenience nectar mixing and storage devices
US20130068771A1 (en) * 2011-09-21 2013-03-21 David Tong Multi-Dye Container
US20130299442A1 (en) * 2010-11-10 2013-11-14 Bahadir Aralp Two-parted bottle which provides mixture of any two liquids in the same volume
US20150018805A1 (en) * 2010-03-16 2015-01-15 Adapta Medical, Inc. Catheter Reservoir Seals
US20150283038A1 (en) * 2014-04-02 2015-10-08 Camellia Abou-Odah Multipurpose Bottle Cap And Methods Of Making And Using Same
US9650175B2 (en) * 2011-08-12 2017-05-16 Kuo-Cheng Wu Container

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1275315A (en) * 1918-03-14 1918-08-13 Thomas O L Smith Bottle.
US1413703A (en) * 1918-12-07 1922-04-25 Abbott Lab Closure for hypodermic-solution containers
US2419453A (en) * 1945-06-08 1947-04-22 Kocevar Anthony Reducing coupling
US2447166A (en) * 1946-12-09 1948-08-17 Daffer Irven William Reversible stopper
US2693189A (en) * 1950-12-15 1954-11-02 Abbott Lab Venoclysis equipment

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1275315A (en) * 1918-03-14 1918-08-13 Thomas O L Smith Bottle.
US1413703A (en) * 1918-12-07 1922-04-25 Abbott Lab Closure for hypodermic-solution containers
US2419453A (en) * 1945-06-08 1947-04-22 Kocevar Anthony Reducing coupling
US2447166A (en) * 1946-12-09 1948-08-17 Daffer Irven William Reversible stopper
US2693189A (en) * 1950-12-15 1954-11-02 Abbott Lab Venoclysis equipment

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3070093A (en) * 1959-02-25 1962-12-25 Stanley J Sarnoff Medicament and diluent storing, mixing, and dispensing device
US3161310A (en) * 1960-10-14 1964-12-15 Baxter Don Inc Parenteral solution container
US4024952A (en) * 1974-10-03 1977-05-24 Koninklijke Emballage Industrie Van Leer B.V. Screw cap for a container
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
WO1984001355A1 (en) * 1982-09-28 1984-04-12 Scholten Bent Henrik Niels Von An aerosol container or similar dispensing device for discharging pressurized liquids
US4453636A (en) * 1983-05-03 1984-06-12 Meadows Bernard A Safe container
US4836370A (en) * 1986-02-03 1989-06-06 Steigmuhle Toss Ag Dual chamber container and method for forming an opening between the chambers of the container
US5088627A (en) * 1990-07-25 1992-02-18 Wheaton Industries Multi-chamber package for mixing and dispensing
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5447226A (en) * 1992-06-09 1995-09-05 Societe De Conseils Et D'eutdes Des Emballages (S.C.E.E.) Dual compartment container with means for mixing and dispensing a product
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US5893452A (en) * 1996-02-15 1999-04-13 L'oreal Monopiece body for the separate packaging and mixing of at least two products
US6022134A (en) * 1996-10-25 2000-02-08 Rxi Plastics, Inc. Mixing and dispensing container
US6001643A (en) * 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
US20030026164A1 (en) * 2001-08-02 2003-02-06 Klein Arnold Gregory Convenience nectar mixing and storage devices
US20060153000A1 (en) * 2001-08-02 2006-07-13 Klein Arnold G Convenience nectar mixing and storage devices
US8147119B2 (en) * 2001-08-02 2012-04-03 Arnold Gregory Klein Convenience nectar mixing and storage devices
US8197116B2 (en) * 2001-08-02 2012-06-12 Klein Arnold G Convenience nectar mixing and storage devices
US20050111300A1 (en) * 2003-10-01 2005-05-26 Berthold Nies Device for the mixing and discharge of liquid and pulverulent materials for medical use
US20150018805A1 (en) * 2010-03-16 2015-01-15 Adapta Medical, Inc. Catheter Reservoir Seals
US20130299442A1 (en) * 2010-11-10 2013-11-14 Bahadir Aralp Two-parted bottle which provides mixture of any two liquids in the same volume
US9650175B2 (en) * 2011-08-12 2017-05-16 Kuo-Cheng Wu Container
US20130068771A1 (en) * 2011-09-21 2013-03-21 David Tong Multi-Dye Container
US9517181B2 (en) * 2014-04-02 2016-12-13 Camellia Abou-Odah Multipurpose bottle cap and methods of making and using same
US20150283038A1 (en) * 2014-04-02 2015-10-08 Camellia Abou-Odah Multipurpose Bottle Cap And Methods Of Making And Using Same
US9902537B2 (en) 2014-04-02 2018-02-27 Camellia Abou-Odah Multipurpose bottle cap and methods of making and using same

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