US3369121A - Radioactive package and container therefor - Google Patents

Radioactive package and container therefor Download PDF

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Publication number
US3369121A
US3369121A US540689A US54068966A US3369121A US 3369121 A US3369121 A US 3369121A US 540689 A US540689 A US 540689A US 54068966 A US54068966 A US 54068966A US 3369121 A US3369121 A US 3369121A
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US
United States
Prior art keywords
column
container
closure
radioactive
package
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US540689A
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English (en)
Inventor
Gerald A Bruno
Thomas A Haney
Numerof Paul
Reinhardt Karl
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ER Squibb and Sons LLC
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ER Squibb and Sons LLC
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Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to US540689A priority Critical patent/US3369121A/en
Priority to GB15334/67A priority patent/GB1136194A/en
Priority to DE1614486A priority patent/DE1614486C2/de
Priority to NL6704921.A priority patent/NL160419C/nl
Priority to FR101729A priority patent/FR1518130A/fr
Application granted granted Critical
Publication of US3369121A publication Critical patent/US3369121A/en
Priority to BE714824D priority patent/BE714824A/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F5/00—Transportable or portable shielded containers
    • G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0042—Technetium

Definitions

  • This invention relates to a new device for containing a column of elutable radioactive material.
  • the device comprises a hollow body, in which the column of radioactive material is contained, closed at its two ends by pierceable closures, preferably made from resilient material. In this manner a closed system is achieved which can be sterilized and remains sterile in use.
  • the device is preferably shipped in a shielding container having a removable closure. The removable closure and the bottom of the container are both apertured so that access can be had to the interior of the container without removing the closure.
  • a hypodermic needle therefor that is used to pass through the aperture in the closure and pierce the top of the device so that the solution can be introduced into the top of the column, a tube containing hypodermic needles at both ends, one needle of which is inserted through the aperture in the bottom of the column into the bottom of the device and the other needle through the closure of an empty sealed vial which is also pierced by another hypodermic needle open to the atmosphere through a sterile plug of cotton, a sterile system for eluting the column and recovering the eluate containing the desired radioactive material is achieved.
  • the preferred radioactive material contains the element Mo yielding radioactive technetium as the eluted radioactive material.
  • This invention relates to packages containing radioactive material and containers therefor and, more particularly, to a package of a sterile column containing a radioactive material and a shielding container therefor and to the sterile column itself.
  • radioactive isotopes for the diagnosis and treatment of various medical conditions.
  • certain radioactive isotopes have so short a half-life that they cannot be economically shipped from the manufacturer to the attending physician. This has made it necessary for the physician to prepare such isotopes as and where they are to be used.
  • One such isotope is the 99m isotope of technetium which is used for the localization of brain tumors, for example.
  • This isotope has a half-life of six hours and is obtained as the daughter product of molybdenum M0 It is separated in the form of the pertechnetate ion from M0 absorbed on an alumina column, by elution with dilute hydrochloric acid or saline. Since maximum growth of radioactivity of the Tc occurs in about 23 hours, a column containing Mo may be eluted daily to yield T0 Because of its high radioactivity, such column must be shielded at all times to prevent unnecessary exposure to its radioactivity.
  • such columns were in the form of open ended cylinders and were shipped in shielding containers, made of lead or a lead salt or other material used as a gamma ray shielding agent.
  • shielding containers made of lead or a lead salt or other material used as a gamma ray shielding agent.
  • col- 3,369,121 Patented Feb. 13, 1968 umns were either removed from the containers, or, if a container having removable closures on bot-h ends was employed, retained in the container during elution.
  • the eluate was collected in a collecting container, such as a beaker or vial, and had to be sterilized prior to use. This necessitated the sterilization of a radioactive substance thereby increasing both the hazard and difficulty in using such a generator system.
  • FIGURE 1 is a perspective view of the separated components that comprise one embodiment of the package of this invention.
  • FIGURE 2 is an axial section view of the package shown in FIGURE 1, with the components assembled and the package closed;
  • FIGURE 3 is an elevational view showing the equipment used to load and wash the column of the package of FIGURE 1 of this invention
  • FIGURE 4 is a perspective view of the separated components that comprise a second embodiment of the package of this invention.
  • FIGURE 5 is an axial section view of the package shown in FIGURE 4, showing the package in use.
  • the package of this invention comprises generally a container having a body 1, a removable top closure 2, and a radioactive column 3 positioned inside the body 1.
  • the container is fabricated of lead or other material used as a gamma ray shielding material, such as a lead-antimony alloy iron, or a lead salt, such as lead carbonate or lead sulfide, embedded in plastic.
  • the body 1 is of generally cylindrical shape having a hollow center 4 preferably of circular cross-section and of greater diameter than that of column 3.
  • a shock absorbant packing material 5 such as corrugated paper, foam plastic or a plastic sleeve.
  • both the bottom wall and the top closure have centrally positioned apertures 6 and 7, sealed by removable plugs 8 and 9, which are also fabricated of gamma shielding materials.
  • the container is closed at its top by means of removable closure 2.
  • the closure is retained on the body by means of a pair of lugs 10, 10, having enlarged heads 11, 11.
  • the closure 2 is equipped with a pair of arcuate keyhold shaped slots 12, 12, the enlarged openings of which are of greater diameter than are the heads 11. These slots are countersunk so that the outer portions thereof are of suflicient width to accomodate the heads, whereas the inner portions thereof are of width smaller than the heads 11, but of sufficient width to accomodate the shank portions of lugs 10.
  • the closure is also fabricated of lead or other material relatively impervious to radioactivity and,
  • the closure is equipped on its inner surface with a circular projection 13 having a circumference slightly less than the circumference of the hollow center.
  • closure 2 is retained on the body by means of lugs and keyhole shaped slots, other means may be used to removably connect the closure to the body.
  • the closure may be simply taped or stapled to the body, or threading may be used.
  • the column 3 is preferably made principally of glass or a transparent plastic material and is composed of a cylindrical tube 14 closed at its top and bottom by means of stoppers 15 and 16.
  • These stoppers are preferably fabricated of resilient material, such as rubber, that can be pierced by a hypodermic needle, and are held permanently in place by means of a pair of annular aluminum discs 17 and 18 that pass over the outer edges of the stoppers, the sides of the stoppers and are then crimped to the adjacent walls of tube 14, as shown in FIGURE 2.
  • the bottom stopper 16 is equipped with a breather tube 19 that passes through stopper 16 to about half the height of tube 14.
  • the bottom stopper 16 is equipped on its outer surface with a groove 20 extending at least from the outer end of breather tube 19 to aperture 6.
  • the breather tube 19 is equipped with a plug 21 of cotton or similar material.
  • the tube 14 is equipped with a partition 22 which divides the tube 14 into an upper and a lower portion.
  • This partition is preferably integral with the tube 14 along its outer end and tapers downward towards the bottom of tube 14 so as to provide a restricted opening 23 at its lower end.
  • the partition can be and preferably is fabricated of the same material as tube 14. Although the exact position of the partition in tube 14 is not critical, it is preferably positioned in the upper half of tube 14 in such a way that the restricted opening 23 is slightly below the upper end of breather tube 19.
  • a perforated disc 24 (preferably a glass fritted disc) on which preferably rests a filter pad 25.
  • the granulation 26 can be retained in place either by use of a perforated disc (prefereably a cloth disc 27 retained in place by a retaining ring 28), as shown in the drawing, or merely by means of stopper 15.
  • a perforated disc prefereably a cloth disc 27 retained in place by a retaining ring 28
  • the granulation 26 is packed into the top portion of the column, the stoppers 15 and 16 are inserted and crimped into place by means of aluminum discs 17 and 18. As shown in FIGURE 3, the top stopper 15 is then pierced by two hollow needles 29 and 30, one of which is connected to a reservoir 31 and the other to a tube 32 open at its other end to the atmosphere. A third hollow needle 33 is inserted through bottom stopper 16 to allow for drainage.
  • the reservoir 31 is filled with a source of radioactivity, such as an aqueous solution of radioactive (M ammonium molybdate, and the solution is permitted to drip through needle 29 onto and through granulation 26. Most of the radioactive molybdenum is adsorbed in the granulation. The excess molybdenum and water pass through the column and are removed through drainage needle 33. The column is then washed with acid and saline to remove any non-adsorbed molybdenum, the needles 29, 30 and 33 are removed, and the column is sterilized, as by autoclaving.
  • a source of radioactivity such as an aqueous solution of radioactive (M ammonium molybdate, and the solution is permitted to drip through needle 29 onto and through granulation 26. Most of the radioactive molybdenum is adsorbed in the granulation. The excess molybdenum and water pass through the column and are removed through drainage needle 33. The column is then washed with acid and saline to remove any non-
  • the column 3 is inserted into body 1.
  • the closure 2 is then so positioned over the top of body 1 that the lugs pass through the enlarged portions of slots 9, and rotated 4 to firmly connect the closure to said body.
  • the package is then ready for shipment.
  • the plugs 8 and 9 are removed and the column 3 is then eluted, by injecting a sterile, non-pyrogenic eluting solution, such as sterile, non-pyrogenic isotonic saline, through the top stopper 15 into the upper portion of tube 14.
  • a sterile, non-pyrogenic eluting solution such as sterile, non-pyrogenic isotonic saline
  • the injection is accomplished by passing the needle of a hypodermic syringe containing the eluting solution through aperture 7 and through stopper 15.
  • the eluate, containing the radioactive material is collected and maintained in the bottom of tube 14.
  • the eluate is to be used, it is removed from tube 14 by piercing the stopper 16 with a sterile hypodermic needle (connected to a syringe) by passing the needle through aperture 6 and stopper 16.
  • the package of this embodiment of the invention differs from the first embodiment primarily in the omission of the lower chamber in the column. It comprises generally a container having a body 101, a removable top closure 102, and a radioactive column 103 positioned inside the body 101.
  • the body 101 and closure 102 are fabricated from gamma ray shielding material as described hereinbefore.
  • the body 101 is of generally cylindrical shape having a hollow center 104 preferably of circular cross-section and of greater diameter than that of column 103.
  • a shock absorbant packing material 105 such as corrugated paper, foam plastic or a plastic sleeve.
  • both the bottom wall and the top closure have centrally positioned apertures 106 and 107, sealed by removable plugs 10 8 and 109, which are also fabricated of gamma shielding materials.
  • the container is closed at its top by means of removable closure 102. This may be done by positioning the closure 102 on the container 101 and affixing it by means of a strip of adhesive tape (not shown) or other means.
  • the closure 10-2 is equipped on its inner surface with a circular projection 113 having a circumference slightly less than the circumference of the hollow center.
  • the column 103 is preferably made principally of glass or a plastic material and is composed of a cylindrical tube 114 closed at its top and bottom by means of stoppers 115 and 116.
  • These stoppers are preferably fabricated of resilient material, such as rubber, that can be pierced by a hypodermic needle and are held permanently in place by means of a pair of annular aluminum discs 117 and 118 that pass over the outer edges of the stoppers, .the sides of the stoppers and are then crimped to the adjacent walls of tube 114, as shown in FIGURE 5.
  • a perforated disc 124 Positioned in the tube 114, preferably spaced from but near the bottom thereof, is a perforated disc 124 (preferably a glass fritted disc) on which preferably rests a filter pad 1 25. Resting on top of disc 124, or the filter pad 125 if one is used, is a granulation 126 of the same material used in the first embodiment. The granulation 126 can be retained in place either by use of a perforated disc 127, as shown in FIGURES 4 and 5 of the drawing, or merely by means of stopper 115.
  • the column is prepared for use by the same method used in the first embodiment of this invention, as shown by FIGURE 3.
  • the loaded column 103 is then inserted into body 101 and the closure 102 is positioned over the opening in body 101 and retained thereon by means of an adhesive strip or other means.
  • the package is then ready for shipment.
  • the plugs 108 and 109 are removed and the column 103 is eluted, by injecting a sterile, non-pyrogenic eluting solution, such as sterile, non-pyrogenic isotonic saline, through the top stopper 115 into the upper portion of tube 114.
  • a sterile, non-pyrogenic eluting solution such as sterile, non-pyrogenic isotonic saline
  • the injection is accomplished by passing the needle of a hypodermic syringe (not shown) containing the eluting solution through aperture 107 and through stopper 115.
  • the eluate, containing the radioactive material is withdrawn from the bottom of tube 114 by means of a hypodermic needle 34.
  • This needle 34 passes through aperture 106 and bottom stopper 116 into the space between perforated disc 124- and stopper 116.
  • stopper 116 is preferably fabricated to have a concave center portion 35.
  • needle 34 is connected through tubing 36 to a second hypodermic needle 37 that passes into a sterile empty vial or other container 38 through a rubber stopper 39 closing the vial and retained thereon by means of a crimped annular aluminum disc 40.
  • the stopper 39 is also pierced by a third hypodermic needle 41, exposed to the atmosphere.
  • needle 41 is equipped with a plug 42 of cotton or similar material.
  • vial 38 is retained in a shield 43 of gamma ray shielding material.
  • the eluate passes from column 103 through needle 34, tubing 36, and needle 37 into vial 38.
  • the eluate is removed from vial 38 by piercing the stopper 39 with .a'sterile hypodermic needle (connected to a syringe).
  • closures 2 and 102 are designated as top closures
  • the columns 3 and 103 respectively, can of course be introduced upside down into the body 1 and 1, in which case the top closure becomes a bottom closure.
  • the packages of this invention By use of the packages of this invention it is possible to carry out the entire elution operation under sterile conditions without ever removing the column 3 or 103 from the protective shield, thereby minimizing the possibility of exposure to the relatively high radioactivity of the column. Furthermore, since the whole eluting operation is carried out under sterile conditions, the need to sterilize the radioactive eluate prior to use is obviated.
  • a column containing a sterile, non-pyrogenic elutable radioactive material to be utilized for diagnosis and treatment of medical conditions which comprises a hollow portable body, closed at its top and bottom by pierceable autoclavable closures and having positioned therein and spaced from the bottom thereof a source of sterile, non-pyrogenic elutable short-lived medical radioactive material whereby a sterile non-pyrogenic eluate immediately ready for utilization is delivered from the column on elution.
  • a package comprising a shielding container and a column containing a sterile non-pyrogenic elutable radioactive material positioned therein; said container having side and bottom Walls, said bottom wall containing a restricted aperture therein; and said column comprising a hollow portable body closed at its top and bottom by pierceable autoclavable closures and having positioned therein and spaced from the bottom thereof a source of sterile, non-pyrogenic elutable short-lived medical radioactive material whereby a sterile non-pyrogenic eluate immediately ready for utilization is delivered from the column on elution.
  • the source of the radioactive material contains the element M0 References Cited UNITED STATES PATENTS 2,682,872 7/1954 Bower 206-6 3.2 X 2,968,721 1/1961 Shapiro et .al. 250-406 X 2,973,758 3/ 1961* :Murrish 206-632.
  • X References Cited UNITED STATES PATENTS 2,682,872 7/1954 Bower 206-6 3.2 X 2,968,721 1/1961 Shapiro et .al. 250-406 X 2,973,758 3/ 1961* :Murrish 206-632.

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US540689A 1966-04-06 1966-04-06 Radioactive package and container therefor Expired - Lifetime US3369121A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US540689A US3369121A (en) 1966-04-06 1966-04-06 Radioactive package and container therefor
GB15334/67A GB1136194A (en) 1966-04-06 1967-04-04 Radioactive package and container therefor
DE1614486A DE1614486C2 (de) 1966-04-06 1967-04-05 Säulenförmiger Hohlkörper zur Aufnahme von radioaktivem Material
NL6704921.A NL160419C (nl) 1966-04-06 1967-04-06 Kolom, die elueerbaar radioactief materiaal bevat.
FR101729A FR1518130A (fr) 1966-04-06 1967-04-06 Ensemble contenant une matière radioactive pouvant être extraite par élution et procédé pour conditionner une telle matière
BE714824D BE714824A (nl) 1966-04-06 1968-05-08

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US540689A US3369121A (en) 1966-04-06 1966-04-06 Radioactive package and container therefor

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US3369121A true US3369121A (en) 1968-02-13

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BE (1) BE714824A (nl)
DE (1) DE1614486C2 (nl)
GB (1) GB1136194A (nl)
NL (1) NL160419C (nl)

Cited By (44)

* Cited by examiner, † Cited by third party
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US3440423A (en) * 1967-04-10 1969-04-22 Squibb & Sons Inc Process for preparing sterile radioactive material of the parentdaughter type
US3446965A (en) * 1966-08-10 1969-05-27 Mallinckrodt Chemical Works Generation and containerization of radioisotopes
US3535085A (en) * 1967-08-07 1970-10-20 Mallinckrodt Chemical Works Closed system generation and containerization of radioisotopes
FR2046951A1 (nl) * 1969-06-20 1971-03-12 Union Carbide Corp
US3576998A (en) * 1966-11-16 1971-05-04 Nen Picker Radiopharmaceutical Self-contained, closed system and method for generating and collecting a short-lived daughter radionuclide from a long-lived parent radionuclide
US3626191A (en) * 1968-02-28 1971-12-07 Commissariat Energie Atomique Ion exchange vessel having hollow cylindrical ring construction for the transfer of a radioactive substance
US3754141A (en) * 1972-07-12 1973-08-21 Atomic Energy Commission Shipping and storage container for high power density radioactive materials
US3766388A (en) * 1971-06-04 1973-10-16 Gen Nuclear Inc Radioactive tracer method and apparatus for boreholes
US3774035A (en) * 1971-07-12 1973-11-20 New England Nuclear Corp Method and system for generating and collecting a radionuclide eluate
US3783291A (en) * 1968-11-25 1974-01-01 Squibb & Sons Inc Sterile generator housing and support
US3801818A (en) * 1972-10-24 1974-04-02 Squibb & Sons Inc Radioactive generator with permeable closure
US3814941A (en) * 1972-10-24 1974-06-04 Squibb & Sons Inc Loading syringe for use with radioactive solutions and other non-sterile solutions
JPS4984600U (nl) * 1973-10-09 1974-07-22
US3926176A (en) * 1973-08-15 1975-12-16 Gen Electric Radioactive gas-containing polymeric capsule
US3957033A (en) * 1973-08-15 1976-05-18 General Electric Company Ventilation study system
US4160910A (en) * 1977-06-20 1979-07-10 Union Carbide Corporation Rechargeable 99MO/99MTC generator system
US4330711A (en) * 1979-04-14 1982-05-18 Stefan Ahner Container combination for the transportation and storage of radioactive waste especially nuclear reactor fuel elements
US4387303A (en) * 1979-03-26 1983-06-07 Byk-Mallinckrodt Cil B.V. Radioisotope generator
EP0172106A1 (en) 1984-08-16 1986-02-19 E.R. Squibb & Sons, Inc. Strontium-82/rubidium-82 generator
DE3531355A1 (de) * 1985-09-03 1987-03-12 Hoechst Ag Technetium-99m-generator, seine herstellung und verwendung
EP0441491A1 (en) 1990-01-18 1991-08-14 Bracco International B.V. Boronic acid adducts of rhenium dioxime and technetium-99M dioxime complexes containing a biochemically active group
US5071965A (en) * 1988-07-19 1991-12-10 Mallinckrodt Medical, Inc. Novel tc-99m complexes
US5109160A (en) * 1990-10-12 1992-04-28 E. I. Du Pont De Nemours And Company Sterilizable radionuclide generator and method for sterilizing the same
US5627286A (en) * 1993-06-15 1997-05-06 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5651954A (en) * 1994-01-12 1997-07-29 Bracco International B.V. Method of using hydrazone containing ligands and metal complexes thereof
US5688487A (en) * 1991-10-29 1997-11-18 Bracco International B.V. Diagnostic imaging methods using rhenium and technetium complexes containing a hypoxia-localizing moiety
US6337052B1 (en) * 1999-11-15 2002-01-08 The Penn State Research Foundation Insulated specimen container
US20050116186A1 (en) * 2002-04-11 2005-06-02 Weisner Peter S. Radioisotope generator
US6989543B2 (en) 2003-08-15 2006-01-24 C.R. Bard, Inc. Radiation shielding container for radioactive sources
US20060076520A1 (en) * 2004-10-12 2006-04-13 Drobnik Christopher D Radiation shielding container that encloses a vial of one or more radioactive seeds
US7186994B1 (en) * 2003-09-17 2007-03-06 The S.M. Stoller Corporation Container for transport of hazardous materials
US20080197302A1 (en) * 2005-07-27 2008-08-21 Fago Frank M Radiation-Shielding Assemblies and Methods of Using the Same
US20100133269A1 (en) * 2005-06-24 2010-06-03 Salvatore Moricca Method and apparatus for isolating material from its processing environment
EP2279757A2 (en) 2000-06-02 2011-02-02 Bracco Suisse SA Compounds for targeting endothelial cells
US20120298880A1 (en) * 2006-10-06 2012-11-29 Mallinckrodt Llc Self-Aligning Radioisotope Elution System and Method
US20120305800A1 (en) * 2011-01-19 2012-12-06 Mallinckrodt Llc Holder and Tool For Radioisotope Elution System
US20140263319A1 (en) * 2013-03-13 2014-09-18 Medrad, Inc. Vial container with collar cap
US8866104B2 (en) 2011-01-19 2014-10-21 Mallinckrodt Llc Radioisotope elution system
WO2015066335A1 (en) * 2013-10-30 2015-05-07 NorthStar Medical Radioisotopes LLC Parent radionuclide container
US9153350B2 (en) 2011-01-19 2015-10-06 Mallinckrodt Llc Protective shroud for nuclear pharmacy generators
US9233776B2 (en) 2012-06-07 2016-01-12 Bayer Healthcare Llc Molecular imaging vial transport container and fluid injection system interface
US9757306B2 (en) 2013-03-13 2017-09-12 Bayer Healthcare Llc Vial container with collar cap
CN109915129A (zh) * 2019-04-30 2019-06-21 北京中百源国际科技创新研究有限公司 一种石油钻井中子勘探设备
US10517971B2 (en) 2016-05-04 2019-12-31 Curium Us Llc Systems and methods for sterilizing sealed radionuclide generator column assemblies

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DE3904149C2 (de) * 1989-02-11 1994-01-20 Kernforschungsz Karlsruhe Vorrichtung an Behältern mit radioaktiven Abfällen zur Verringerung des Innendrucks durch Wasserstoffbildung
ITRM20020071A1 (it) 2002-02-11 2003-08-11 Sigma Tau Ind Farmaceuti Contenitore per flacone di radiofarmaco, e corredo per la sua infusione in un paziente o per il suo trasferimento altrove.

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US2682872A (en) * 1950-06-29 1954-07-06 John O Bower Absorbable wound pad
US2968721A (en) * 1954-09-27 1961-01-17 Tracerlab Inc Methods of flow rate measurement
US2973758A (en) * 1956-12-27 1961-03-07 Invenex Pharmaceuticals Apparatus for manufacturing parenteral solutions

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US2682872A (en) * 1950-06-29 1954-07-06 John O Bower Absorbable wound pad
US2968721A (en) * 1954-09-27 1961-01-17 Tracerlab Inc Methods of flow rate measurement
US2973758A (en) * 1956-12-27 1961-03-07 Invenex Pharmaceuticals Apparatus for manufacturing parenteral solutions

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446965A (en) * 1966-08-10 1969-05-27 Mallinckrodt Chemical Works Generation and containerization of radioisotopes
US3576998A (en) * 1966-11-16 1971-05-04 Nen Picker Radiopharmaceutical Self-contained, closed system and method for generating and collecting a short-lived daughter radionuclide from a long-lived parent radionuclide
US3440423A (en) * 1967-04-10 1969-04-22 Squibb & Sons Inc Process for preparing sterile radioactive material of the parentdaughter type
US3535085A (en) * 1967-08-07 1970-10-20 Mallinckrodt Chemical Works Closed system generation and containerization of radioisotopes
US3626191A (en) * 1968-02-28 1971-12-07 Commissariat Energie Atomique Ion exchange vessel having hollow cylindrical ring construction for the transfer of a radioactive substance
US3783291A (en) * 1968-11-25 1974-01-01 Squibb & Sons Inc Sterile generator housing and support
FR2046951A1 (nl) * 1969-06-20 1971-03-12 Union Carbide Corp
US3766388A (en) * 1971-06-04 1973-10-16 Gen Nuclear Inc Radioactive tracer method and apparatus for boreholes
US3774035A (en) * 1971-07-12 1973-11-20 New England Nuclear Corp Method and system for generating and collecting a radionuclide eluate
US3754141A (en) * 1972-07-12 1973-08-21 Atomic Energy Commission Shipping and storage container for high power density radioactive materials
US3801818A (en) * 1972-10-24 1974-04-02 Squibb & Sons Inc Radioactive generator with permeable closure
US3814941A (en) * 1972-10-24 1974-06-04 Squibb & Sons Inc Loading syringe for use with radioactive solutions and other non-sterile solutions
US3926176A (en) * 1973-08-15 1975-12-16 Gen Electric Radioactive gas-containing polymeric capsule
US3957033A (en) * 1973-08-15 1976-05-18 General Electric Company Ventilation study system
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BE714824A (nl) 1968-09-30
DE1614486B1 (de) 1970-09-03
NL6704921A (nl) 1967-10-09
NL160419C (nl) 1979-10-15
GB1136194A (en) 1968-12-11
DE1614486C2 (de) 1975-07-10

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