US2973758A - Apparatus for manufacturing parenteral solutions - Google Patents

Apparatus for manufacturing parenteral solutions Download PDF

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US2973758A
US2973758A US63086756A US2973758A US 2973758 A US2973758 A US 2973758A US 63086756 A US63086756 A US 63086756A US 2973758 A US2973758 A US 2973758A
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bottle
small
device
apparatus
manufacturing
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Clarence L Murrish
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Invenex Pharmaceuticals
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2017Piercing means having three or more piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068Venting means
    • A61J1/2075Venting means for external venting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00General characteristics or adaptations
    • A61J2200/70Device provided with specific sensor or indicating means
    • A61J2200/76Device provided with specific sensor or indicating means for fluid level

Description

C. L. MURRISH March 7, 1961 APPARATUS FOR MANUFACTURING PARENTERAL SOLUTIONS Filed Dec. 27, 1956 f/GLZ INVENTOR. CLARENCE L. MURR/SH A T TO 4. A MEMBER OF THE wa -t.

United States Patent 2,973,758 APPARATUS FOR MANUFACTURING PARENTERAL'SOLUTIONS j Clarence L. Murrish, San Francisco, Calif., assignor to Iuvenex Pharmaceuticals, a corporation of California .Filed Dec. 27,1956, Ser. No. 630,867

4 Claims. (Cl."128-- -272)' invention relates to a method and apparatus for the preparation of solutions and, more particularly relates to the preparation of solutions for parenteral administration.

In the past, it has been the practice to prepare solutions forinjection in a laboratory under sterile conditions, and to supply hospitals and the like with the completely prepared solution for injection. However, more recently, it has become the practice to employ an ever-increasing number of different substances for administration such as various salts, amino acids, antibiotics, and the like, and these are frequently prescribed in various concentrations. Thus, it has become almost impossible for a hospital to carry in stock pre-mixed solutions of all the substances which may be desired for injection. It has become the present practice to provide pre-packaged sterile liquids comprising a relatively few stock items, such as distilled water, normal saline solution, and glucose solution, and to provide in addition thereto small bottles of the various substances which are desired for administration in'concentrated form and to prepare the final solution for administration by mixing varying amounts of one or more of the concentrated solutions from the small bottles with the standard stock solutions which would normally be carried in administration bottles. In this manner, the inventory necessary for a hospital to carry is greatly reduced since it is only necessary to carry afew types of standard solutions for injection and a number of small bottles of concentrated solutions with a minimum of manipulation and under asceptic conditions.

In general, the object of the present invention is accomplished by providing a cap or cap-like article having two needles therethrough, whereby liquid in' a small bottle may be drawn into an administration bottle without coming into contact with the air.

In the drawings forming a part of this application:

Figure 1 is a side view of a large bottle, such as is commonly employed forparenteral administration, together with a small bottle of a concentrated solution and the device of the present invention, which is adapted to transfer the contents of the small bottle into the large bottle.

Figure 2 is an enlarged sectional view showing the device of the present invention in place,;transferring the contents of a small bottle into a large bottle.

Figure 3 is a perspective view of a modification wherein a series of guides are provided for guiding the small bottle into the proper position for transfer.

Figure 4 illustrates another modification of the invention wherein a sleeve is used as a guide and also wherein a we a cover is provided to keep the device of the present invention sterile.

Referring now to the drawing by reference characters, there is shown an administration bottle 5 having a band 7, and a bail 9. The bottle is normally provided' with'one or: more scales 11, for determining the contents of the bottle, and the bottle is filled to a level 13, which is substantially below the top of the bottle, and the space above the contents is evacuated. The bottle may also have an air inlet tube 15, which is normally sealed. The top of the bottle is closed by means of a rubber stopper 17, which is held in place by an annular band 19. The rubber stopper 17 ordinarily contains one or more openings which do not. go completely through the stopper, as all, and which 'are, in efiect, closed by a diaphragm 'so that'one or more needles can be easily inserted into thhe stopper. The exact method of closure varies with various manufacturers of the bot tles and is not here described in more detail since it forms no part of the present invention. Also illustrated is a small bottle 23, which is closed by means of a rubber stopper 25, which is held in place by the band 27. The bottle 23 is ordinarily provided with a scale 29, and is filled with a concentrated solution of a salt or other substance to be injected.

The device of the present invention is generally designated 31, and has a cap-like member 33 through which needles 35 and 37 are rigidly held in place. The needle 35 has two sharpened ends 39 and 41, which extend on each side of the cap-like member 33, so that the point 41 will penetrate the stopper 17 of the large bottle, while the point 39 is adapted to penetrate the stopper 25 of' the small bottle. Needle 37 has a single sharpened end 43, and the opposite end terminates flush with the cap, as at 45. In the embodiment shown, the needle points 39 and 43 lie on a common plant, although they may be of various lengths and the point 43 may be extended until it reaches substantially to the'bottom of the small bottle.

To use the device of the present invention, the needles 35 and 37 are first plunged through the stopper 25 of the small bottle, the small bottle is inverted and then the needle point 41 is inserted through the stopper 17 of the large bottle, the small bottle being inverted. Since the space above the liquid in the large bottle 5 is under vacuum, liquid will be drawn through the needle 35 from the small bottle into the large bottle and air will flow into the small bottle through the needle 37 to displace the liquid. The amount of liquid which is added from the small bottle may be measured by means of the scale 29, and when the desired amount has been transferred, the member 31 is lifted from the large bottle, whereupon the stopper 17 reseals itself so that an absolutely sterile transfer of liquid from one bottle to the other has been made.

Various variations of the present invention may be made. For instance, in Figure 3 an embodiment is shown wherein the cap member 33 is enlarged so that its inside surface is about equal in diameter to the diameter of the small bottle, and a plurality of upstanding guides 47 are provided which guide the small bottle into the needles accurately and thus facilitate the insertion of the device on a small bottle. In Figure 3 there is also shown a needle retainer 49, which is preferably made of a sterilizable plastic such as nylon, and such retainers may be slipped over the needles after the device has been sterilized to maintain the needles in a sterile condition.

Still another embodiment of the invention is shown in Figure 4' wherein the walls of the cap-like member have been extended as at 51, to provide a skirt which serves as a guide for inserting the device into the small bottle. Preferably, the skirt is at least partially split, as at 53,

so that the small bottle may be inserted in such a manner that the graduations can be read through the slot. Also in Figure 4 is shown a two-part container 55 and 57', in whichithe device of the present invention may be inserted after it has been sterilized and thus its sterility may be maintained for an indefinite length of time after it is taken out of an autoclave. Preferably,'the sections 55 and 57 threadably engage each otheras at 59, to hold the two parts together in an air-tight manner. Preferably, the containeris made of a sterilizable plastic material.

I claim:

1. A device for transferring a solution from one stoppered bottle to another comprising a central member adapted to hold a. pair of hollow needles in spaced par- 15 allel relationship, one of said needles extending on both sides of the central member and having both ends thereof sharpened for the penetration of stoppers and the second needle extending only from one side of said central member, said extending end being sharpened and a guide member attached to the central member, extending in the same direction as the twolsharpened needles.

2. The device of claim 1 wherein the guide comprises a plurality of spaced fingers.

3. The device of claim 1 wherein the guide comprises an annular skirt.

4. The device of claim 1 wherein asterilizable case surrounds the device for preserving sterility.

References Cited'in the file of this patent UNITED STATES PATENTS 1,526,595 Gillman Feb. 17, 1925 2,568,108 Barton Sept. 18, 1951 2,584,397 Pitman Feb. 5, 1952 FOREIGN PATENTS 458,274 .Germany Apr. 2, 1928 971,839 France Aug. 16, 1950

US63086756 1956-12-27 1956-12-27 Apparatus for manufacturing parenteral solutions Expired - Lifetime US2973758A (en)

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Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161034A (en) * 1963-05-09 1964-12-15 Meyers Frederick Charles Butane lighter construction
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
US3369708A (en) * 1965-09-07 1968-02-20 Lincoln Lab Inc Means for reconstituting a dry biological and for controlled dispensing thereof
US3484849A (en) * 1966-07-02 1969-12-16 Gruenenthal Chemie Auxiliary transfer device
US3608550A (en) * 1969-05-07 1971-09-28 Becton Dickinson Co Transfer needle assembly
US3848581A (en) * 1971-10-08 1974-11-19 L Cinqualbre Apparatus for taking multiple samples of biological liquid
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
US3938520A (en) * 1974-06-10 1976-02-17 Abbott Laboratories Transfer unit having a dual channel transfer member
US4537593A (en) * 1983-06-06 1985-08-27 Becton, Dickinson And Co. Self-venting, non-coring needle assembly
US4684365A (en) * 1985-01-24 1987-08-04 Eaton Corporation Disposable refill unit for implanted medication infusion device
US4896454A (en) * 1988-05-27 1990-01-30 Duane Cronenwett Apparatus and method for treating trees
US5555920A (en) * 1991-04-30 1996-09-17 Automed Corporation Method and apparatus for aliquotting blood serum or blood plasma
US5653686A (en) * 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US5853034A (en) * 1995-08-04 1998-12-29 Ecolab Inc. Dispensing system and method for dispensing a concentrated product and container for use therewith
FR2785178A1 (en) * 1998-11-04 2000-05-05 Aguettant Lab Reconstitution system for powdered or liquid medication in bottle and liquid solvent from pouch has graduated scale on bottle and spaces above and below it
US20030078589A1 (en) * 1998-04-01 2003-04-24 Preissman Howard E. High pressure applicator
US20040116892A1 (en) * 2001-03-27 2004-06-17 Burroughs Andrew Christopher Kit including side firing syringe needle for preparing a drug in an injection pen cartridge
US20040215202A1 (en) * 1998-04-01 2004-10-28 Preissman Howard E. High pressure applicator
US20050113843A1 (en) * 2003-11-25 2005-05-26 Arramon Yves P. Remotely actuated system for bone cement delivery
US20060133193A1 (en) * 2004-12-17 2006-06-22 Arthrocare Corporation High pressure injection system for delivering therapeutic agents having fluid tight connector
US20060164913A1 (en) * 2005-01-21 2006-07-27 Arthrocare Corporation Multi-chamber integrated mixing and delivery system
US20060266372A1 (en) * 1999-09-30 2006-11-30 Arthrocare Corporation High pressure delivery system
US20080264261A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269713A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Automated filling systems and methods
US20080269681A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269687A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Adhesive Patch Systems and Methods
US20090270762A1 (en) * 2008-04-24 2009-10-29 Yokogawa Electric Corporation Medical adapter and chemical reaction cartridge
US20110004184A1 (en) * 2007-10-01 2011-01-06 Karl-Heinz Proksch Device for introducing medicine into an infusion container
US20130079744A1 (en) * 2010-07-12 2013-03-28 Jms Co., Ltd. Drug solution delivery device for medical use
US8540692B2 (en) 2007-03-09 2013-09-24 Icu Medical, Inc. Adaptors for removing medicinal fluids from vials
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US8827977B2 (en) 2006-04-12 2014-09-09 Icu Medical, Inc. Vial adaptors and methods for regulating pressure
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US9351905B2 (en) 2008-08-20 2016-05-31 Icu Medical, Inc. Anti-reflux vial adaptors
US10117807B2 (en) 2013-01-23 2018-11-06 Icu Medical, Inc. Pressure-regulating devices for transferring medicinal fluid
US10201476B2 (en) 2014-06-20 2019-02-12 Icu Medical, Inc. Pressure-regulating vial adaptors
US10299989B2 (en) 2012-03-22 2019-05-28 Icu Medical, Inc. Pressure-regulating vial adaptors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1526595A (en) * 1922-08-21 1925-02-17 Gillman George Blood-extracting device
DE458274C (en) * 1925-06-06 1928-04-02 Jules Alfred Ferdinand Container closure, consisting of a two channels having plugs for taking a certain Fluessigkeitsmenge
FR971839A (en) * 1948-09-20 1951-01-22 A device for manipulating a liquid protected from the outside air
US2568108A (en) * 1949-09-28 1951-09-18 Mead Johnson & Co Dispensing closure for sterile liquid containers
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1526595A (en) * 1922-08-21 1925-02-17 Gillman George Blood-extracting device
DE458274C (en) * 1925-06-06 1928-04-02 Jules Alfred Ferdinand Container closure, consisting of a two channels having plugs for taking a certain Fluessigkeitsmenge
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
FR971839A (en) * 1948-09-20 1951-01-22 A device for manipulating a liquid protected from the outside air
US2568108A (en) * 1949-09-28 1951-09-18 Mead Johnson & Co Dispensing closure for sterile liquid containers

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161034A (en) * 1963-05-09 1964-12-15 Meyers Frederick Charles Butane lighter construction
US3369708A (en) * 1965-09-07 1968-02-20 Lincoln Lab Inc Means for reconstituting a dry biological and for controlled dispensing thereof
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
US3484849A (en) * 1966-07-02 1969-12-16 Gruenenthal Chemie Auxiliary transfer device
US3608550A (en) * 1969-05-07 1971-09-28 Becton Dickinson Co Transfer needle assembly
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3848581A (en) * 1971-10-08 1974-11-19 L Cinqualbre Apparatus for taking multiple samples of biological liquid
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
US3938520A (en) * 1974-06-10 1976-02-17 Abbott Laboratories Transfer unit having a dual channel transfer member
US4537593A (en) * 1983-06-06 1985-08-27 Becton, Dickinson And Co. Self-venting, non-coring needle assembly
US4684365A (en) * 1985-01-24 1987-08-04 Eaton Corporation Disposable refill unit for implanted medication infusion device
US4896454A (en) * 1988-05-27 1990-01-30 Duane Cronenwett Apparatus and method for treating trees
US5555920A (en) * 1991-04-30 1996-09-17 Automed Corporation Method and apparatus for aliquotting blood serum or blood plasma
US5653686A (en) * 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US5853034A (en) * 1995-08-04 1998-12-29 Ecolab Inc. Dispensing system and method for dispensing a concentrated product and container for use therewith
US6105638A (en) * 1995-08-04 2000-08-22 Ecolab Inc. Dispensing system and method for dispensing a concentrated product and container for use therewith
US7572263B2 (en) 1998-04-01 2009-08-11 Arthrocare Corporation High pressure applicator
US20040215202A1 (en) * 1998-04-01 2004-10-28 Preissman Howard E. High pressure applicator
US20030078589A1 (en) * 1998-04-01 2003-04-24 Preissman Howard E. High pressure applicator
FR2785178A1 (en) * 1998-11-04 2000-05-05 Aguettant Lab Reconstitution system for powdered or liquid medication in bottle and liquid solvent from pouch has graduated scale on bottle and spaces above and below it
US20060266372A1 (en) * 1999-09-30 2006-11-30 Arthrocare Corporation High pressure delivery system
US8123756B2 (en) * 1999-09-30 2012-02-28 Neurotherm, Inc. High pressure delivery system
US7195623B2 (en) 2001-03-27 2007-03-27 Eli Lilly And Company Kit including side firing syringe needle for preparing a drug in an injection pen cartridge
US20040116892A1 (en) * 2001-03-27 2004-06-17 Burroughs Andrew Christopher Kit including side firing syringe needle for preparing a drug in an injection pen cartridge
US20050113843A1 (en) * 2003-11-25 2005-05-26 Arramon Yves P. Remotely actuated system for bone cement delivery
US20060133193A1 (en) * 2004-12-17 2006-06-22 Arthrocare Corporation High pressure injection system for delivering therapeutic agents having fluid tight connector
US20060164913A1 (en) * 2005-01-21 2006-07-27 Arthrocare Corporation Multi-chamber integrated mixing and delivery system
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US9072657B2 (en) 2006-04-12 2015-07-07 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US9005180B2 (en) 2006-04-12 2015-04-14 Icu Medical, Inc. Vial adaptors and methods for regulating pressure
US9005179B2 (en) 2006-04-12 2015-04-14 Icu Medical, Inc. Pressure-regulating apparatus for withdrawing medicinal fluid from a vial
US8992501B2 (en) 2006-04-12 2015-03-31 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US8882738B2 (en) 2006-04-12 2014-11-11 Icu Medical, Inc. Locking vial adaptors and methods
US8827977B2 (en) 2006-04-12 2014-09-09 Icu Medical, Inc. Vial adaptors and methods for regulating pressure
US9060921B2 (en) 2006-04-12 2015-06-23 Icu Medical, Inc. Air-filtering vial adaptors and methods
US8945084B2 (en) 2006-04-12 2015-02-03 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US8540692B2 (en) 2007-03-09 2013-09-24 Icu Medical, Inc. Adaptors for removing medicinal fluids from vials
US9107808B2 (en) 2007-03-09 2015-08-18 Icu Medical, Inc. Adaptors for removing medicinal fluids from a container
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8025658B2 (en) 2007-04-30 2011-09-27 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8083716B2 (en) 2007-04-30 2011-12-27 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US9980879B2 (en) 2007-04-30 2018-05-29 Medtronic Minimed, Inc. Automated filling systems and methods
US8172929B2 (en) 2007-04-30 2012-05-08 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US9901514B2 (en) 2007-04-30 2018-02-27 Medtronic Minimed, Inc. Automated filling systems and methods
US9522225B2 (en) 2007-04-30 2016-12-20 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20110230834A1 (en) * 2007-04-30 2011-09-22 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8597270B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Automated filling systems and methods
US7963954B2 (en) * 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US9205191B2 (en) 2007-04-30 2015-12-08 Medtronic Minimed, Inc. Automated filling systems and methods
US20090198191A1 (en) * 2007-04-30 2009-08-06 Medtronic Minimed, Inc. Adhesive patch systems and methods
US20090198215A1 (en) * 2007-04-30 2009-08-06 Medtronic Minimed, Inc. Adhesive patch systems and methods
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269687A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Adhesive Patch Systems and Methods
US20080269681A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269713A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Automated filling systems and methods
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US9089641B2 (en) 2007-04-30 2015-07-28 Medtronic Minimed, Inc. Automated filling systems and methods
US20080264261A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
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