US3192106A - Gas mixtures containing nitrous oxide - Google Patents
Gas mixtures containing nitrous oxide Download PDFInfo
- Publication number
- US3192106A US3192106A US216301A US21630162A US3192106A US 3192106 A US3192106 A US 3192106A US 216301 A US216301 A US 216301A US 21630162 A US21630162 A US 21630162A US 3192106 A US3192106 A US 3192106A
- Authority
- US
- United States
- Prior art keywords
- nitrous oxide
- pressure
- mixture
- oxygen
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/104—Preparation of respiratory gases or vapours specially adapted for anaesthetics
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/22—Nitrous oxide (N2O)
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
- C01B21/26—Preparation by catalytic or non-catalytic oxidation of ammonia
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C13/00—Details of vessels or of the filling or discharging of vessels
Definitions
- Oxygen is one of the so-called permanent gases, that is to say, it remains in the gas phase at ambient temperatures whatever the pressure.
- the pressure in an oxygen cylinder progressively falls ,as the contents are used and does not vary much with the ambient temperature.
- a pressure gauge can therefore, serve as a simple contents indicator.
- nitrous oxide can be and usually the present invention.
- the cylinders are designed for such duty and it is uneconomic to use them for the storage and transport of gases at considerably lower pressures;
- a method of forming ahomogeneous mixture of a permanenfgas, and ,up to 75% of nitrous oxide comprises charging the gases in the predetermined required proportions into a pressure container until a pressure is'reached at which the partial is stored under pressure in the liquid phase. Under static 7 effect on pressure. No simple means for determining the contents of a nitrous oxide cylinder under normal conditions of use is available and there is therefore a danger that the supply of nitrous oxide will-run out unexpectedly.
- the mixture iscompressed to at. least 132 atmospheres.
- a homogeneous gaseous medium comprising up to 75% nitrous oxide in admixture with a permanent 'gas confined in a container at a pressure such that the oxide is greater than.50.atmospartial pressure of nitrous oxide is greater than 50 atmospheres.
- the permanent gas most commonly used with nitrous oxide is oxygen.
- a nitrous oxide/ oxygen mixture containing nitrous oxide in the range of 50 to 60% is frequently administered.
- a more potent drug such as halothane or cyclopropane may be added as a constituent of the nitrous oxide/oxygen mixture.
- halothane halothane
- cyclopropane may be included in the nitrous oxide/ oxygen mixture as the potent adjuvant, while maintaining the contents of the pressure container entirely in-the gaseous phase.
- the mixture may be inflammable and the usual precautions should be taken to guard against risk of static discharge.
- the required proportion of nitrous oxide is preferably charged into a valved pressure container first, the quantity being determined either by weight or by volume.
- the required'proportionof permanent gas then added, either continuously or intermittently so as to allow equilibrium to take place.
- the attainment of equilibrium namely the complete disappearance of the liquid phase, may be accelerated by agitating the contents.
- the container may be shaken during charging with oxygen,
- the container may be rolled about after charging.
- the container may be inverted so that the. oxygen bubbles through the liquid nitrous oxide.
- the nitrous oxide and oxygen are charged simultaneously into the container.
- the two gases are preferably premixed, either in a gas holder from which they are pumped into the container, or continuously by the method known as streaming in in which the flow rates of the separate gas streams are adjusted to produce the correct mixture.
- the invention may be illustrated by the following example.
- a standard'compressed gas cylinder was used having a nominal compressed gas capacity of 220 cu. ft. at 132 atmospheres pressure.
- a weighed amount of nitrous oxide was charged into the cylinder, following which oxygen was introduced until the pressure reached 135 atmospheres.
- the composition of the mixture was found on analysis to be 74.9 of nitrous oxide and 25.1% of oxygen.
- the cylinder was allowed to discharge, and at intervals samples of the issuing gas were taken from the cylinder in its normal upright position and in the inverted position.
- the nitrous oxide content of the samples was determined by measurement of the difference between the refractive index of the gas mixture and that of oxygen. The results obtained which are subject to an error of i0.2% were as follows: 1
- nitrous oxide with-permanent gases other than oxygen can be prepared in a manner. similar to that described above to yield a mixture of constant composition, evenif the partial, pressure of nitrous oxide isin excess of 50 ats.
- a specific example of such amixture is a nitrous oxide/nitrogen mixture containing up to 75% nitrous oxide in a pressure container to 132 ats.
- Such mixtures are of use in leak detection, using infra red apparatus where it is necessary for the test procedure to be conducted at relatively high pressure. Such high pressure testing is sometimes necessary for detecting leaks in water mains and other hydraulic equipment such as tubular condensers.
- the method of forming a homogeneous mixture of a permanent gas .and nitrous oxide which comprises charging the nitrous oxide into a valved pressure container, subsequently charging into the same container a permanent gas so that the subsequent mixture includes from 15 up to 75% by volume of nitrous oxide,and until a final pressure is reached at which the partial'pressure of nitrous oxide is greater than 50 ats.
- the method of forming a homogeneousmixture of a permanent gas and of nitrous oxide which comprises charging the gases in proportions of from 15% up to 75% by volume of the nitrous oxide into a pressure container until a final pressure is reached at which the partial pressure of nitrous oxide is greater than 50 ats.
- the method of forming a homogeneous mixture of oxygen and nitrous oxide which comprises charging the gases in proportions of from 15% up to 75% volume of the nitrous oxide into a pressure container until a final pressure is reached at which the partial pressure of nitrous oxide is-greater than 50 ats.
- a pressurized dispensing container Within which is a homogeneous gaseous medium comprising from 15% up to 75% by volume of nitrous oxide in admixture with a permanent gas, the partial pressure of nitrous oxide being greater than 50 ats.
- a pressurized dispensing container within which is a homogeneous gaseous medium comprising up to 75% by volume of nitrous oxide in admixture with oxygen, the partial pressure of nitrous oxide being greater than SO ats.
- a pressurized dispensing container within which is a homogeneous gaseous medium comprising from 15% up to 75 by volume of nitrous oxide in admixture with oxygen and from a trace up 1% by volume of halothane, the partial pressure of nitrous oxide being greater than 50 ats.
- a pressurized dispensing container within which is a homogeneous gaseous medium comprising from 15 up to 75% by volume of nitrous oxide in admixture with oxygen and from a trace up to 5% by volume of cyclopropane, the partial pressure of nitrous oxide being greater than 50 ats.
- a pressurized dispensing container within which is a homogeneous gaseous medium comprising from 15% up to 75% by volume of nitrous oxide in admixture with nitrogen, the partial pressure of nitrous oxide being greater than ats.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB29417/61A GB967930A (en) | 1961-08-15 | 1961-08-15 | Gas mixtures containing nitrous oxide |
Publications (1)
Publication Number | Publication Date |
---|---|
US3192106A true US3192106A (en) | 1965-06-29 |
Family
ID=10291248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US216301A Expired - Lifetime US3192106A (en) | 1961-08-15 | 1962-08-13 | Gas mixtures containing nitrous oxide |
Country Status (5)
Country | Link |
---|---|
US (1) | US3192106A (es) |
BE (1) | BE660318A (es) |
DE (1) | DE1183051B (es) |
FR (1) | FR1511552A (es) |
GB (1) | GB967930A (es) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876773A (en) * | 1973-05-15 | 1975-04-08 | British Oxygen Co Ltd | Gas mixtures containing nitrous oxide |
FR2473885A1 (fr) * | 1980-01-18 | 1981-07-24 | Fix R | Procede d'obtention d'un moyen therapeutique sous forme gazeuse, dispositif pour la mise en oeuvre de ce procede, et moyen therapeutique ainsi obtenu |
US5846556A (en) * | 1996-06-14 | 1998-12-08 | Brooks; Bradley S. | Inhalant for reducing stress and method of use |
US20040129270A1 (en) * | 2002-08-20 | 2004-07-08 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US6793644B2 (en) * | 2000-12-26 | 2004-09-21 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20050028816A1 (en) * | 2002-08-20 | 2005-02-10 | Aga Linde Healthcare | Methods for easing pain and anxiety from atrial or ventricular defibrillation |
US20060147553A1 (en) * | 1998-11-23 | 2006-07-06 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US20060207594A1 (en) * | 1999-11-24 | 2006-09-21 | Alex Stenzler | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
US20070014688A1 (en) * | 2002-09-10 | 2007-01-18 | Douglas Hole | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
US20070088316A1 (en) * | 2000-12-26 | 2007-04-19 | Alex Stenzler | Device and method for treatment of wounds with nitric oxide |
US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US20070104653A1 (en) * | 2004-05-11 | 2007-05-10 | Miller Christopher C | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
US20080097282A1 (en) * | 2006-10-20 | 2008-04-24 | Hole Douglas R | Methods and devices for the delivery of therapeutic gases including nitric oxide |
US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
US7955294B2 (en) | 2004-05-11 | 2011-06-07 | Sensormedics Corporation | Intermittent dosing of nitric oxide gas |
WO2013175087A1 (fr) * | 2012-05-24 | 2013-11-28 | Air Liquide Sante (International) | Conditionnement d'un mélange gazeux no/azote à haute concentration en no |
WO2013175089A1 (fr) * | 2012-05-24 | 2013-11-28 | Air Liquide Sante (International) | Conditionnement à haute pression d'un mélange gazeux no/azote |
CN104337830A (zh) * | 2013-11-12 | 2015-02-11 | 余建强 | 一种无成瘾性吸入脱毒剂 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2996427A (en) * | 1958-11-20 | 1961-08-15 | James G Robson | Anaesthetic consisting of nitrous oxide and halothane |
-
0
- BE BE660318D patent/BE660318A/xx unknown
-
1961
- 1961-08-15 GB GB29417/61A patent/GB967930A/en not_active Expired
-
1962
- 1962-08-13 US US216301A patent/US3192106A/en not_active Expired - Lifetime
- 1962-08-13 FR FR906854A patent/FR1511552A/fr not_active Expired
- 1962-08-13 DE DEB68400A patent/DE1183051B/de active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2996427A (en) * | 1958-11-20 | 1961-08-15 | James G Robson | Anaesthetic consisting of nitrous oxide and halothane |
Cited By (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876773A (en) * | 1973-05-15 | 1975-04-08 | British Oxygen Co Ltd | Gas mixtures containing nitrous oxide |
FR2473885A1 (fr) * | 1980-01-18 | 1981-07-24 | Fix R | Procede d'obtention d'un moyen therapeutique sous forme gazeuse, dispositif pour la mise en oeuvre de ce procede, et moyen therapeutique ainsi obtenu |
EP0032872A2 (fr) * | 1980-01-18 | 1981-07-29 | Roger Fix | Procédé d'obtention d'un moyen thérapeutique, sous forme gazeuse, et moyen thérapeutique ainsi obtenu |
EP0032872B1 (fr) * | 1980-01-18 | 1984-10-17 | Roger Fix | Procédé d'obtention d'un moyen thérapeutique, sous forme gazeuse, et moyen thérapeutique ainsi obtenu |
US5846556A (en) * | 1996-06-14 | 1998-12-08 | Brooks; Bradley S. | Inhalant for reducing stress and method of use |
US20060147553A1 (en) * | 1998-11-23 | 2006-07-06 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US20060207594A1 (en) * | 1999-11-24 | 2006-09-21 | Alex Stenzler | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
US7516742B2 (en) | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
US8795222B2 (en) | 2000-12-26 | 2014-08-05 | Pulmonox Technologies Corp. | Device and method for treatment of surface infections with nitric oxide |
US6793644B2 (en) * | 2000-12-26 | 2004-09-21 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20110112468A1 (en) * | 2000-12-26 | 2011-05-12 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20050137521A1 (en) * | 2000-12-26 | 2005-06-23 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US7892198B2 (en) | 2000-12-26 | 2011-02-22 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20080287861A1 (en) * | 2000-12-26 | 2008-11-20 | Alex Stenzler | Device and method for treatment of wounds with nitric oxide |
US20070088316A1 (en) * | 2000-12-26 | 2007-04-19 | Alex Stenzler | Device and method for treatment of wounds with nitric oxide |
US7520866B2 (en) | 2000-12-26 | 2009-04-21 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
US7681572B2 (en) | 2002-08-20 | 2010-03-23 | Aga Ab | Method and devices for administration of therapeutic gases |
US20070068523A1 (en) * | 2002-08-20 | 2007-03-29 | Aga Ab | Method for administration of therapeutic gases |
US20040129270A1 (en) * | 2002-08-20 | 2004-07-08 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US20050028816A1 (en) * | 2002-08-20 | 2005-02-10 | Aga Linde Healthcare | Methods for easing pain and anxiety from atrial or ventricular defibrillation |
US7337776B2 (en) | 2002-08-20 | 2008-03-04 | Aga Ab | Methods for easing pain and anxiety from atrial or ventricular defibrillation |
US20090044804A1 (en) * | 2002-08-20 | 2009-02-19 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US20090065001A1 (en) * | 2002-08-20 | 2009-03-12 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US20090071481A1 (en) * | 2002-08-20 | 2009-03-19 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US20090071474A1 (en) * | 2002-08-20 | 2009-03-19 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US20090071475A1 (en) * | 2002-08-20 | 2009-03-19 | Aga Linde Healthcare | Method and devices for administration of therapeutic gases |
US7531133B2 (en) | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
US20070014688A1 (en) * | 2002-09-10 | 2007-01-18 | Douglas Hole | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
US20070104653A1 (en) * | 2004-05-11 | 2007-05-10 | Miller Christopher C | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
US8518457B2 (en) | 2004-05-11 | 2013-08-27 | Pulmonox Technologies Corporation | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
US7955294B2 (en) | 2004-05-11 | 2011-06-07 | Sensormedics Corporation | Intermittent dosing of nitric oxide gas |
US20110226241A1 (en) * | 2004-05-11 | 2011-09-22 | Sensormedics Corporation | Intermittent dosing of nitric oxide gas |
US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
US8079998B2 (en) | 2006-10-20 | 2011-12-20 | Pulmonox Technologies Corporation | Methods and devices for the delivery of therapeutic gases including nitric oxide |
US20080097282A1 (en) * | 2006-10-20 | 2008-04-24 | Hole Douglas R | Methods and devices for the delivery of therapeutic gases including nitric oxide |
US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
WO2013175087A1 (fr) * | 2012-05-24 | 2013-11-28 | Air Liquide Sante (International) | Conditionnement d'un mélange gazeux no/azote à haute concentration en no |
WO2013175089A1 (fr) * | 2012-05-24 | 2013-11-28 | Air Liquide Sante (International) | Conditionnement à haute pression d'un mélange gazeux no/azote |
FR2991026A1 (fr) * | 2012-05-24 | 2013-11-29 | Air Liquide Sante Int | Conditionnement a haute pression d'un melange gazeux no/azote |
FR2991025A1 (fr) * | 2012-05-24 | 2013-11-29 | Air Liquide Sante Int | Conditionnement d'un melange gazeux no/azote a haute concentration en no |
CN104337830A (zh) * | 2013-11-12 | 2015-02-11 | 余建强 | 一种无成瘾性吸入脱毒剂 |
Also Published As
Publication number | Publication date |
---|---|
GB967930A (en) | 1964-08-26 |
FR1511552A (fr) | 1968-02-02 |
BE660318A (es) | |
DE1183051B (de) | 1964-12-10 |
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