US3157179A - Aerosol device - Google Patents

Aerosol device Download PDF

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Publication number
US3157179A
US3157179A US220599A US22059962A US3157179A US 3157179 A US3157179 A US 3157179A US 220599 A US220599 A US 220599A US 22059962 A US22059962 A US 22059962A US 3157179 A US3157179 A US 3157179A
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United States
Prior art keywords
metering
container
plunger
chamber
metering plunger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US220599A
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English (en)
Inventor
Clarence L Paullus
William M Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL297349D priority Critical patent/NL297349A/xx
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to US220599A priority patent/US3157179A/en
Priority to GB32756/63A priority patent/GB1025245A/en
Priority to DEM57990A priority patent/DE1287260B/de
Priority to FR946236A priority patent/FR1374533A/fr
Priority to SE9508/63A priority patent/SE317467B/xx
Application granted granted Critical
Publication of US3157179A publication Critical patent/US3157179A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44—Valves specially adapted therefor; Regulating devices
    • B65D83/52—Valves specially adapted therefor; Regulating devices for metering
    • B65D83/54—Metering valves ; Metering valve assemblies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered

Definitions

  • Vessels containing aerosols and the like are presently used for many purposes. In many instances it is desirable to have a standardized amount of the pressurized material released from the container.
  • This invention provides apparatus for isolating and discharging a predetermined amount of the material in a pressurized container.
  • dispensers of the aerosol type has also become increasing popular in the administration of medicaments.
  • One problem associated with the administration of medicaments in the form or" a spray or aerosol is controlling the amount or dosage of medicine received by the patient. Attempts to solve this problem have resulted in the appearance of numerous varieties of dosage valves and metering devices throughout the art. The majority of such devices are unreliable in controlling quantity, while others are generally expensive in conthere is no guarantee that the patient will be inhaling when the spray is released. More important, there is'no guarantee that the patient will be just beginning to inhale when the spray is released. In order for all of the medicament to be delivered deep into the respiratory system, the patient should be at the beginning of inhalation at exactly the moment the measured dosage is released.
  • a construction for a pneumatic metering valve includes means for measuring a predetermined amount of medicament and means for triggering the valve to release the predetermined amount of medicament to the patients respiratory system by the patients inhalation and at the beginning of the inhalation.
  • One advantage of the construction is that a measured amount of medicament is released when the patient first begins to inhale so that the medicament is drawn deeply into the respiratory tract and will consequently be of greater benefit to the patient. The patient need not consciously try to coordinate breathing and valve triggering since it is automatic.
  • Another advantage of this invention is that the duration or intensity of the inhalation does not influence the dosage or the amount of medicament that is released since the dosage is standardized regardless of individual differences in operation or breathing. Still other advantages are inherent in the construction of the dosage chamber providing for: the elimination of gases or fluids from the dosage chamber before it is filled with medicament, positioning of the chamber outside the container during storage so that the medicament 7 3,..l57,l i Patented Nov.
  • the chamber can be made small and accurate, there are no extraneous articles (such as springs, plunger stems, etc.) in the chamber for the medicament to collect upon, and the volume of the chamber is not influenced by miscellaneous parts within the chamber.
  • FIG. 1 is a perspective view of the external portions of the pneumatically released aerosol device
  • FIG. 2 illustrates the use of the pneumatically released aerosol device by a patient
  • FIG. 3 is an exploded view showing the various parts of the pneumatically released aerosol device according to this invention.
  • FIGS. 4l0 are sectional views of the pneumatically released aerosol device showing different relative positions of various parts in order to illustrate the operation, the individual figures being described as follows:
  • PEG. 4 shows the aerosol device in the initial position, which is the position after the metered quantity of the contents of the aerosol container have been discharged;
  • FIG. 5 shows the position of the parts in the first step of the cocking operation, when the push button has been partially depressed
  • FIG. 6 shows the position of the parts in the second step of the cocking operation when the push button has been further depressed
  • FIG. 7 shows the position of the parts in the third step of the cocking operation, when the push button has been fully depressed
  • FIG. 8 shows the position of the parts in the final step of the cocking operation, when the push button has been released and the device is in cocked position
  • FIG. 9 shows the position of the parts in the first step of the pneumatic releasing operation
  • FIG. 10 shows the position of the parts in the final step of the pneumatic releasing operation, and shows the contents of the metering chamber being discharged into the mouthpiece;
  • FIG. ll is a sectional view of a second embodiment of the invention.
  • FIG. 12 is a perspective view of the retainer and valve stem used in the embodiment of FIG. 11.
  • FIG. 13 is a sectional view of a manually released aerosol device.
  • FIG. 14 is an enlarged fragmentary sectional view of a portion of FIG. 13.
  • the dosage apparatus 11 is shown in the normal operating position with the push button 13 below the container portion 15.
  • the apparatus Ill could, of course, operate in any positionrwith most aerosol ma I terials, but many medicaments will be of such a'n'ature that the most advantageous positional attitude for optimum operation will be the position shown in the drawings. From the external view (FIG. 1), a push button 13, container 15, mouthpiece 17 and vent openings l9-19 can be seen.
  • FIG. 2 shows how the patient uses the apparatus by placing the mouthpiece 17 in his mouth.
  • the apparatus 11 has been cocked since the patient has pressed the button 13.
  • the preferred construction provides a mouthpiece 17 shaped so that the container position tilts away from the face.
  • the dosage which was metered out by the patients pressing button 13, will be released into the patients oral cavity. Continued inhalation will pass the dose of medicament deeper into the respiratory system.
  • the valve portion 21 is mounted on the container 15.
  • the container has a flange 23 around an opening 25 and an extension 27 projecting below the flange 23 that aids in enclosing and retaining valve portion 21.
  • the method and construction for attaching and mounting the valve portion 21 to the container 15 may be modified so that a variety of sizes and shapes of containers can be attached to the valve portion 21.
  • the container 15 has been constructed to fit the valve conveniently allowing many of the parts to be press-fitted together thereby saving time and expense in assembling the apparatus.
  • a valve body or actuator retainer 29 is press-fitted into the container extension 27 over the opening 25 and fits against a seal such as a gasket 31.
  • the retainer 29 is cylindrical with a flange 33 at one end.
  • a central bore 35 passes through the flanged end of the retainer 29 and the length of the bore 35 is substantially equal to the height of the flange 33.
  • the bore 35 communicates with a larger bore 37 that continues from bore 35 to the opposite end of the retainer 29.
  • Two slots 39-39 in the cylindrical wall of the retainer 29 and substantially opposite one another, and extend from the unflanged end of the retainer 29 to a point about midway between the ends of retainer 29.
  • a groove 41 on the outside surface of the cylinder walls, extends from the end of each slot 39 to the flange 33.
  • a hole 43 passes through the wall of the retainer 29 at each slot 39 and the center of the hole 43 is aligned with the centerline of the slot 39.
  • a detent ball 45 fits snugly into each hole 43.
  • a passage 47 aligned with a line passing through both of the slots 39-39 and positioned in about the middle of flange 33, communicates between the exterior cylindrical surface of flange 33 and an orifice chamber 49 that is positioned in the interior cylindrical surface of flange 33.
  • the orifice chamber 49 is open to the bore 35.
  • a metering plunger 50 includes a valve stem 51 that is fitted snugly into bore 35 and extends through bore 37.
  • Two guides 53-53 extend in a winglike manner from the outer surface 55 of valve stem 51 and are positioned in the slots 2929.
  • Each guide 53 has an edge 57 substantially parallel to the outer surface 55 of the valve stem 51, an end 59 that is inclined or at an approximate fortyfive degree angle with respect to the outer surface 55, and an opposite end 61 substantially perpendicular to the outer surface 55.
  • the valve stem 51 has two centrally located bores. One is a piston bore as that communicates with one end of the valve stem 51 and the other is a smaller piston rod bore 65 that extends from piston bore 63 to the opposite end of valve stem 51.
  • An expurgatory piston 67 fits into the bore 63.
  • the metering plunger 5! also includes a valve stem plug 71 that is press fitted to valve stem 51 over the end opening of bore 63, and an expurgatory piston seal 73 is disposed between the end of stem 51 and plug 71 covering the end of piston 67.
  • the cylindrical side wall 74 of plug 71 engages the inner edge of gasket 31 in a sliding sealing fit.
  • the plug 71 has an enlarged end 75 that bears on seal 31 preventing the stem 51 rom moving out of bore 35.
  • a metering chamber '77 is centrally located in plug 71 and has an orifice 79 communicating with the outside surface of plug 71 that, in the position of the apparatus as shown in FIG. 4, communicates with the orifice chamber 49.
  • Resilient means such as a spring 81 bears against a seal 83 at the end of bore 37 and the ends 6161 of guides 5353 urging the valve stem 51 downward so that the enlarged end '75 of valve stem plug 71 bears on seal 31.
  • the spring 81 is not absolutely necessary to operation of the valve since most propellants that are used in aerosol-type containers generate enough pressure to supply the energy for urging the valve stem to its downward position (FIG. 4).
  • a cylindrical actuator 85 slips over the outside of the retainer 23.
  • the outer edge of a flanged end portion 87 fits against the inside surface 8% of the container extention 27.
  • Two ridges or guides 91 extend inwardly from opposite sides of the inside surface 93 of actuator 85 and are fitted into retainer slots 3933 and retainer grooves d141.
  • each guide 91 is wider forming an ear or projection 95.
  • Each projection 95 has an edge 97 that is parallel to the inner surface 93 of actuator 85 and an edge 99 that is inclined or at an approximate fortyfive degree angle with respect to inner surface 93.
  • a valve cocking button 13 is affixed to the end of the piston rod 69.
  • the button 13 is cup-shaped, with the outside surface of the sidewall 101 slidably engaged with the inner surface 39 of container extension 27.
  • An opening 103 is formed in the side wall 1611 providing communication from the exterior to the interior of button 13.
  • a ridge 1115 is positioned on the outside of sidewall 191 opposite the opening 163. The ridge 105 fits into a groove 107 in the inside surface 39 of container extension 27 and prevents the button 13 from being rotated around its attachment to the end of piston rod 69.
  • a nozzle 199 having a stem 111 fits through the wall of container extension 27 and communicates with the retainer passage 47. Surrounding the nozzle m9 is the mouthpiece 17 attached to the container 15. An opening 113 in the wall of container extension 27 communicates with the interior of the mouthpiece 17 and the space 115 below the actuator flange 87. On the opposite side of the container extension 27 is at least one vent opening 19 that communicates with a space 117 above the actuator flange 87.
  • FIG. 4 shows the valve in the uncooked position.
  • Each detent ball 45 is confined in hole 43 between an edge 57 of stem guide 53 and edge 99 of actuator guide 91.
  • the metering chamber 77 has been discharged and, in the position of FIG. 4, is filled with residual medicament or air, depending upon the time that has elapsed since the apparatus 11 was last operated.
  • the valve is cocked by pressing on button 13.
  • the first change in position (shown in FIG. 5) moves the piston 67 into the metering chamber 77 stretching the piston seal 73 and eliminating any aerosol or air that is present in the metering chamber '77 by forcing it out through the orifice 79 and eventually through the nozzle 1&9 by means of the orificecharnber and passage 47.
  • This feature onsures that later when the metering chamber 77 is filled, it is completely filled with a completely fresh charge of medicament obtained from the container supply so that the dosage is a standard amount.
  • valve stem 51 moves upward against the force of spring 81 and the force of the propellant pressure in the container 15.
  • the orifice 79 moves past seal 31 and into the container 15.
  • the valve stem 51 moves upward until the inclined edges 5959 pass the detent balls 4545 (shown in *TG. 6). The detent balls 4545 are thus free to move toward the valve stem 51.
  • the button 13 is pushed still farther upward to the position shown in FIG. 7. At about the position of FIG. 6
  • the rim 119 of button 13 contacts a washer 12.1 positioned against actuator flange 87.
  • the washer 121 has tabs 123l23 bent to provide a spring force between button 13 and actuator 85 while the button rim 11d and actuator flange 37 are in close proximity.
  • the actuator 35 is forced upward until the actuator flange 87 contacts the retainer flange 33.
  • theinclined edge 99 of projection 95 moves the detent balls d-d5 inwardly toward valve stem 51.
  • each detent ball 45 is loosely confined by the sides of the hole 43, valve stem guide edge 59 and actuator projection edge 97.
  • FIG. 8 shows the apparatus after the button 13 is released.
  • the pressure in the aerosol container 15 forces piston 67 from the metering chamber 77 filling the chamber 77 with medicament.
  • the valve stem 51 also tends to be forced downward by the pressure in the container 15, aided by the force of spring 81, until the inclined edges 5) 59 of guides 553-53 contact the detent balls 45-45.
  • the detent balls d5--4i5 are held against the edges 59-59 by the edges 9797 of the actuator projections 95-% preventing the valve stem from moving further downward.
  • the actuator 35 tends to follow the button 13 when it is released but is prevented by the spring force produced by the tabs 123-l23 on washer 121.
  • the actuator 85 is therefore held against the retainer flange 33 until the guide edges 5959 exert pressure on detent balls 45-45.
  • the detent balls 4545 are forced outward by the guide edges 59-59 pressure is exerted on the parallel edges 977 of actuator projections 95-95 and prevents the actuator 85 from moving after the button 13 is released completely.
  • the metering chamber 77 is filled and positioned in the container 15. If the actuator 85 is moved downward the detent balls td-45 are released and the valve stem 51 can also move downward until the enlarged plug end 75 comes to rest against gasket 31. Note that in the position of FIG. 8, the button opening 103 coincides with the container extension opening 113.
  • the patient places the mouthpiece 17 in his mouth (as shown in FIG. 2) and inhales or sucks on the mouthpiece. This causes a partial vacuum in the space 115 below actuator rim 87.
  • the atmospheric pressure in the space 117 above the actuator flange 37 forces the actuator 85 downward as shown in 1 16.9. Movement of the actuator 35 downward causes the edges 97-97 of the actuator projections 95-95 to pass the detent balls 45-d5.
  • the detent balls 45-45 are 'thus free to move outwardlyand release the valve stem 51.
  • valve stem 51 After the valve stem 51 is released, it moves rapidly to the position of FIG. 10. In the meantime, the patient is still inhaling.
  • the orifice 79 moves opposite the orifice chamber 49 and releases the medicament from the metering chambers 77 to the nozzle M9. The patient at this time draws the medicament deep into his respiratory tract.
  • button 13 moves downward with the valve stem l5 during inhalation, the opening 1% passes by the end of container extension 27. Thisallows the patient to obtain air for continued inhalation by opening space 115 to the atmosphere so the patient has a source of air for continued inhalation carrying the medicament into his lungs. Otherwise, the patients inhalation would be curtailed as soon as the pressure in space 115 was reduced to a value that caused the patient to struggle to get air.
  • the air that is admitted through opening 103 into space 115 also supplies air for vaporization of the medicament.
  • FIGS. 11 and 12 show a construction for another embodiment of a dosage apparatus 11'. Additional features of the constructions shown in FIGS. 11 and 12 are also usable for the dosage apparatus 11 shown in FIGS. 1-10.
  • the dosage apparatus 11 has essentially the same external appearance as that shown in FIG. 1.
  • the valve stem 51 is constructed with an enlarged portion 125 that completely encircles the stern St.
  • the enlarged portion 125 has an inclined surface 127 at the lower end and 3.23 at the upper end.
  • the enlarged portion 125 replaces the guides 53 shown in FIGS. 1-10.
  • the retainer 2% is provided with a plurality of fingers l29-l29 each having an enlarged end 131.
  • the enlarged end 131 of each finger T29 is provided with an inclined surface 133 positioned to engage the inclined surface 127 of the valve stem 51.
  • the fingers 12d 129 replace the holes 43-4-3, and detent balls l5d5 shown in FIGS. 1-10.
  • the actuator has an inwardly projecting annular ridge 135 with an inclined surface 137.
  • the annular ridge 135 replaces the projections shown in FIGS. 1-10.
  • the apparatus 11 is shown in the cocked position.
  • the spring fil is omitted in this embodiment since the force of the propellant is sufficient to move the valve stem 51' downward.
  • the fingers 129 are bendable, and when the patient inhales, thereby moving the actuator 85' downward, the fingers 129 which were held against enlarged portion are released so that they are free to move outward away from stem 51' disengaging the enlarged portion 125 so that the stem can move downward.
  • the button 13' is pushed upward forcing the enlarged portion 125 past the enlarged finger ends ISL-131.
  • the inclined surface 128 forces the ends 129- 329 apart.
  • the inclined surface 137 of annular ridge forces the fingers 12.9 inwardly and holds them in engagement with enlarged portion 125. This holds the valve stem 51' in the upward position until the actuator 85. moves downward and trees the finger ends 1311 allowing them to pop outward and release the valve stem.
  • the embodiment shown in FIG. 11 is constructed so that the supply of medicament may be replaced.
  • the container 15 is constructed with a first chamber 13*? and a second chamber 141.
  • the charnbers are divided by a partition E i-3 having an opening M5 with the opening surrounded by a gasket 147.
  • a puncturing device 149 has a point 151 projecting into the opening 145.
  • the top of the container is provided with threads 153.
  • a bottle 155 having a thin seal 157 over the bottle opening 158 is also provided with threads 159 at its other end.
  • the bottle neck 161 is inserted into the partition opening 145 and then threaded into position in the container 15.
  • Suitable lugs 163 are provided so that the bottle 155 can be twisted to engage the threads 1153 and 159. As the bottle 155 is threaded into container the puncturing device 149 breaks the seal 157 so that the contents of the bottle 155 are released to the first charn or 139. The gasket 147' keeps the first chamber 13) sealed oil" from the second chamber by being squeezed against the bottle neck 161.
  • FIG. 13 shows a construction for a manually released aerosol device 211.
  • the device uses the features that are responsible for releasing a standard quantity of aerosol, but omits the features that are responsible for pneuaatically releasing the device after it has been cocked.
  • the valve portion 221 is mounted on a container 215.
  • the container 215 has a flange 223 around an opening 225 and an extension 227 projecting below the flange 7 223 that aids in enclosing and retaining the valve portion fice chamber 249 in the surface of bore 235.
  • a passage 247 communicates between the exterior of flange 233 and orifice chamber 247.
  • a metering plunger 25G having a valve stem 251i is fitted snugly into bore 235 and extends from both ends of bore 235.
  • the valve stem 251 has two centrally located bores. One is a piston bore 263 that communicates with one end of the valve stem 251 and the other is a smaller piston rod bore 265 .that extends from piston bore 263 to the opposite end of valve stem 251.
  • An expurgatory piston 267 fits into bore
  • a piston rod 269 attached to piston 267 fits into bore 265 and extends from one end of the valve stem 251.
  • the metering plunger 25% also includes a plug 71 that is pressfitted to valve stem 251 over the end opening of bore 263.
  • An expurgatory piston seal 273 is disposed between the end of stem 251 and plug 271 covering the end of piston 267.
  • the cylindrical sidewall 274 of plug 271 engages the inner edge of gasket 231 in a sliding sealing fit.
  • a gasket 276 is provided in bore 235 below orifice chamber 24-9 to create a seal between valve stem 251 and bore 235.
  • the plug 271 has an enlarged end 275 that bears on seal 23-1 preventing the stem 25]. from moving out of bore 235.
  • A. metering chamber 277 is centrally located in plug 271 and has an orifice 279 communicating with the outside surface of plug 271 that, in the position of the apparatus as shown in FIG. 13, communicates with orifice chamber 249.
  • a button 284? is afiixed to the end of piston rod 269 providing a surface to press on when the apparatus 211 is to be cooked.
  • a plate 282 is attached to valve body 229 and provides a mounting foundation for the manually operated detent apparatus 28
  • the detent apparatus is preferably a pivotally mounted arm 286 having a hook 288 at one end and is attached to a spring 290 at the opposite end.
  • An extension 292 is provided on the spring attached end of arm 2%.
  • cap 298, Mounted at the bottom of valve portion 221 is cap 298, which may be press-fited or screw-fitted to the valve portion 221;.
  • This cap includes the detent release mechanism 326 having a release button 295 at the bottom of push rod 294 extending downwardly outside the cap 298.
  • the push rod 2% is normally biased downwardly by spring 321 acting between collar 322 secured to push rod 294 and sleeve 323, which is a part of cap 2%.
  • Buttons 28% and 296 are threaded or press-fitted onto the rods 269 and 294, respectively, to facilitate assembly.
  • Pressing button 280 purges chamber 277 and moves the metering chamber 277 into the container 215 by moving the plunger 250 upward.
  • the spring 2% forces the hook 288 over the end 3% of valve stem 251 and holds the plunger upward.
  • push rod 294 bears on extension 292 forcing the hook 283 out of engagement with the end 3% of valve stem 251 allowing the pressure in container 215 to force the plunger 25f downward releasing the contents of metering chamber 277 to the nozzle 3%.
  • the above-described apparatus except for the spring 73 and seals, is preferably constructed from a plastic material which makes it light and inexpensive. Various parts can be glued into position. Other materials are, of course, also acceptable, but the construction of the apparatus, unlike conventional valves, is especially suited for plastic materials.
  • this invention as embodied in the construction of FIGS. l-10, includes a pocket-size container 11 containing a mixture of finely divided solid material (such as a medicament) and a propellant that is gaseous at room temperature, but most of which is liquid under atmospheric pressure at room temperature to which it is subjected in the container.
  • the finely divided solid material is substantially insoluble in the liquid propellant.
  • a gasket 31 closes off the container 15 near the container opening 25.
  • the dispensing means 21 and container opening 25 are at the lowermost end of the dispensing apparatus 11 when the dispensing apparatus 11 is in the operating position.
  • the gasket 31 has an opening therein that fits around the exterior surface 74 of the valve stem plug 71 On the metering plunger 59 and provides a seal thereat while the metering plunger 50 is moved axially toward and away from the interior of the container 15 between a depressed position and an extended position of the metering plunger 59 relative to the container 15.
  • the valve stem plug 71 on the metering plunger 50 has a small hollow metering chamber 77 therein and also a passageway between the metering chamber 77 and an opening 79 in the exterior sidewall 74 of the valve stem plug 71 of the metering plunger 5%
  • the opening 79 is positioned axially on the valve stem plug 71 on the metering plunger 50 so that it is on the container 15 side of the gasket 31 when the metering plunger 50 is in the depressed position and so that the opening 79 is on the exterior side of the gasket 31 when the metering plunger 55 is in the extended position.
  • the opening 79 connects with the portion of the metering chamber 77 which is lowermost when the apparatus 11 is in the discharging position so that most of the contents of the metering chamber 77 drain downwardly out through the opening 79 when the metering plunger 50 is in the extended position. This results in a rapid and complete discharge of the metering chamber 77.
  • the metering plunger 50 includes a movable member, such as piston 67 for moving a wall of metering chamber 77, such as piston seal 73. The movement of the wall or seal 73 is from a chamber-forming position, m which the metering chamber 77 has its normal volume, to a chamber-collapsed position, in which the metering chamber has substantially no volume.
  • Operating means are available, such as button 13, for moving the metering plunger 55 against the action of a spring 81 into the depressed position so that the metering chamber 77 is filled through the opening 79 with an accurately determined small amount of the contents of the aerosol container 15.
  • the button 13 also moves the movable member 67 from chamber-forming position to chamber-collapsed position before the button 13 moves the metering plunger 50 to the depressed position, thereby expelling the air from the metering chamber 77 before the metering chamber opening 79 passes from the exterior side to the container side of the gasket 31.
  • a latch including the detent balls 4545, valve stem guide 5353 and actuator projections 95, secures the metering plunger 5!
  • the latch for securing the metering plunger 50 in depressed position could, if desired, be arranged to be released manually, as shown in FIG. 13.
  • the latch is released automatically in response to inhalation by the user.
  • This pneumatic release is achieved by providing a movable member 87 (i.e., the flanged end 87 of actuator 85) with an air chamber 117 on the upper side thereof and another air chamber 115 on the bottom side thereof, and by providing an opening 1% from the upper air-chamber 117 to the atmosphere, and an opening from the lower air chamber 115 to the mouthpiece 1'7.
  • a device constructed as described in FIGS. 1-10 discharges an unusually small metered dose of material-about 35 milligrams by weight (or about 25 microliters by volume as measured in the containers), where the active medicament in the aerosol container is a finely divided solid that is substantially insoluble in the propellant, with the amount of active medicament, in each dose discharged by the device, uniform .to .a remarkable degree over many successive doses until the container is substantially empty, regardless of the length of time transp-iring between doses, and without introducing air into the container as the device is used, and so without introducing into the container something that might cause chemical instability in the medicament.
  • the metering chamber 7'7 could, if desired, be made still smaller than 25 microliters withadmitting air relatively freely to said conduit means, for
  • While the invention is panticlularly useful with finely divided solid medicaments that are substantially insoluble in the Freon types of propellants that are commonly used at the present time in aerosol devices, and particularly where it is desired to have such a rnedieament delivered deep into the respiratory system of a person, various aspects of the invention are also useful where the medicaments (whether solid or liquid) are soluble in the propellants, and where the material propolled by the propellants is not a medicament.
  • an aerosol container and spray device for use in administering small measured amounts of the contents of the aerosol container to a human being through one of his breathing openings, said device including:
  • conduit means efiective when said isolated amount of pressurized fluid is released from said metering chamber into said conduit means, for directing said isolated amount of pressurized fluid, and the spray resulting therefrom, into a breathing opening of the human being, 7
  • said manually actuated means includes means for maintaining said small amount of pressurized fluid isolated in said metering chamber, and unreleased into said conduit means, when said manually actuated means is released;
  • said device includes breath actuated means, responsive to the reduced pressure incident to an attempt to inhale air through said conduit inhalation by the individual, as soon as the contents of said metering chamber are released into the conduit means.
  • an aerosol container and spray device for use in administering small measured amounts of the contents of the aerosol container to a human being through one of his breathing openings, said device including:
  • a generally cylindrical metering plunger said metering plunger being movable axially toward and away from the interior of said container between a depressed position and an extended position relative to said container;
  • the improved operating means for controlling and operating said metering plunger comprising:
  • a manually operated device connected to said metering plunger for manually moving said metering plunger, against the action of the propellent pressure, from extended position to depressed position, in which position said metering chamber is filled through said orifice with an accurately determined amount of the contents of said container;
  • a breathing tube for connecting said aerosol device to said breathing opening of the human being by which the human being can inhale through said i reathing tube, said metering chamber orifice being positioned, when the metering plunger is in extended position, to discharge the contents of the metering chamber into the breathing tube and toward the end thereof lodged in the breathing opening of the human being;
  • said metering plunger includes a movable member serving as a wall for said hollow metering chamber, the movement of said member being from a chamber-forming position in which the metering chamber has its normal volume, to a chamber-collapsed position in which the metering chamber has substantially no volume
  • said opening means also including mechanism for moving said movable member from chamber-forming position to chamber-collapsed position before the operating means moves the metering plunger to depressed position, thereby expelling the air from the metering chamber before the metering chamber opening passes from the exterior side to the container side of the gasket, the operating means being effective, after the metering plunger is moved to depressed position, to cause the movable member to move from chamber-collapsed position to chamber-forming position before the operating means moves the metering plunger sufficiently toward the extended position to move the metering chamber opening from the chamber side of the gasket, thereby enabling said metering chamber to be completely filled with the desired measured amount of
  • Apparatus for dispensing predetermined amounts of pressurized fluid and the like from a container containing said fluid and having an opening therein comprising:
  • valve body having a central bore and a communication passage from said central bore to said mouthpiece;
  • (g) means, activated by the reduction in pressure in said mouthpiece resulting from the users breath intake at said mouthpiece, for moving said plunger from said second position to said first position.
  • (1') piston actuating means effective to move the piston to its small volume position just prior to the time said plunger is moved from its first position to its second position, thereby removing most of the air from said chamber before said chamber is in communication with the interior of the container.
  • Apparatus for dispensing predetermined amounts of pressurized fluid and the like from a container containing said fluid and having an opening therein comprising:
  • valve body having a central bore and a communication passage from said central bore to said mouthpiece;
  • detent means engaging said plunger in said second position and restraining said plunger in said second position
  • Apparatus for dispensing predetermined amounts of pressurized fluid and the like from a container containing said fluid and having an opening therein comprising:
  • valve body having a central bore and communication passage from said central bore to said mouthpiece;
  • detent means engaging said plunger in said second position and restraining said plunger in said second position
  • valve body having a central bore and a communication passage from said central bore to said mouthpiece
  • detent means movable to engage said metering plunger in said second position restraining said metering plunger in said second position
  • actuator means movable with said metering plunger from said first position to said second position, said actuator means positioned to engage and move said detent means into engagement with said metering plunger;
  • an aerosol container and spray device for use in dispensing small measured amounts of the contents of the aerosol container, said device including:
  • a generally cylindrical metering plunger said metering plunger being movable axially toward and away from the interior of said container between a depressed position and an extended position relative to said container, the movement of said metering plunger from extended position to depressed position being against a restoring force provided by the propellant pressure of the contents of the container and any spring which may be provided tending to urge said metering plunger toward extended position;
  • operating means serving to move said metering plunger from extended position to depressed position at the start of a dispensing cycle to eitect the filling of the metering chamber with the measured amount of the contents of the container, said operating means thereafter enabling said metering plunger to move, in response to said restoring force, from depressed position to extended position to effect the discharge of thecontents of the metering chamber through said orifice;
  • said operating means also includes mechanism, effective upon the initial operation of said operating means, to remove substantially all the air from said metering chamber before the metering plunger moves suificiently to move said orifice from the exterior side of said gasket, and thereupon toprevent the inflow of air into said metering chamber while the metering plunger is moved to the depressed position, said mechanism, after said metering plunger is moved to the depressed position, operating to admit to the metering chamber sufiicient of the contents of the aerosol container to fill the metering chamber, before the operating means renders the restoring force efiective to move the metering plunger into the extended position.
  • said metering plunger includes a movable member serving as a wall for said hollow metering chamber, the movement of said member being from a chamber-forming position in'which the metering chamber has its normal volume, to a chamber-collapsed position in which the metering chamber has substantially no volume, and in which said mechanism of said operating means moves said movable member from chamberforrning position to chamber-collapsed position before the operating means at the start of a dispensing cycle, moves the metering plunger from extended position to depressed position, thereby expelling the air from the metering chamber before the metering chamber orifice passes from the exterior side to the container side of the gasket.
  • an aerosol container and spray device as described in claim 14 in which the operating means includes latch means for securing said metering plunger in the depressed position, and also includes release means, independently operable after the operating means has moved said metering plunger to the depressed position, for releasing said latch means and thereby enabling said metering plunger to move, in response to said restoring force, from the depressed position to the extended position to effect the discharge of the contents of the metering chamber through said orifice.
  • said operating means includes two manually operable controls, one for actuation of the portion of said operating means which moves said metering plunger from extended position to depressed position, and the other for actuation of said release means.
  • said device including:
  • a generally cylindrical metering plunger said metering plunger being movable axially toward and away from the interior of said container between a depressed position and an extended position relative to said container, the movement of said metering plunger from extended position to depressed position being against a restoring force provided by the propellant pressure of the contents of the container and any spring which may be provided tending to urge said metering plunger toward extended position;
  • an orifice communicating between said metering chamber and the sidewall of said metering plunger, said orifice being positioned axially on said metering plunger so that it is on the container side of said gasket when said metering plunger is in said depressed position and so that said orifice is on the 15 exterior side of said gasket when said metering plunger is in said extended position; and (f) operating means serving to move said metering plunger from extended position to depressed position at the start of a dispensing cycle to effect the filling of the metering chamber With the measured amount of the contents of the container, said op erating means thereafter enabling said metering plunger to move, in response to said restoring force, from depressed position to extended position to effect the discharge of the contents of the metering chamber through said orifice; the improvement wherein said operating means includes latch means for securing said metering plunger in the depressed position, and also includes release means, independently operable after the operating means has moved said metering plunger to the
  • said operating means includes two manually operable controls, one for actuation of the portion of said operating means which moves said metering plunger from extended position to depressed position, and the other for actuation of said release means.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
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US220599A 1962-08-31 1962-08-31 Aerosol device Expired - Lifetime US3157179A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
NL297349D NL297349A (fi) 1962-08-31
US220599A US3157179A (en) 1962-08-31 1962-08-31 Aerosol device
GB32756/63A GB1025245A (en) 1962-08-31 1963-08-19 Aerosol device
DEM57990A DE1287260B (de) 1962-08-31 1963-08-28 Spraygeraet
FR946236A FR1374533A (fr) 1962-08-31 1963-08-30 Appareil pour distribuer des quantités prédéterminées d'un fluide sous pression à partir d'un récipient
SE9508/63A SE317467B (fi) 1962-08-31 1963-08-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US220599A US3157179A (en) 1962-08-31 1962-08-31 Aerosol device

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US3157179A true US3157179A (en) 1964-11-17

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US220599A Expired - Lifetime US3157179A (en) 1962-08-31 1962-08-31 Aerosol device

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US (1) US3157179A (fi)
DE (1) DE1287260B (fi)
GB (1) GB1025245A (fi)
NL (1) NL297349A (fi)
SE (1) SE317467B (fi)

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US3636949A (en) * 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
US3721240A (en) * 1970-11-10 1973-03-20 M Tamburri Mechanical smoking device
US3838686A (en) * 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US4130116A (en) * 1976-08-13 1978-12-19 Sigma Tau S.P.A. Industrie Farmaceutiche Riunite Pocket inhalator
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US5184761A (en) * 1990-09-20 1993-02-09 Bespak Plc Dispensing apparatus
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5297542A (en) * 1989-06-22 1994-03-29 Raymond J. Bacon Aerosol dispensing device
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5822980A (en) * 1997-07-01 1998-10-20 Chen; Jack Device for reducing molecular pollutants in the gases from a combustion engine
DE29817001U1 (de) 1997-09-22 1998-12-24 Bespak plc, King's Lynn, Norfolk Druckausgabevorrichtung
FR2775668A1 (fr) * 1998-03-04 1999-09-10 Tebro Dispositif de distribution de produit fluide declenche par l'inhalation
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6516796B1 (en) * 1998-10-14 2003-02-11 Chrysalis Technologies Incorporated Aerosol generator and methods of making and using an aerosol generator
US20030079743A1 (en) * 2001-10-30 2003-05-01 Genova Perry A. Breath actuated dry powder inhaler
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US20030108342A1 (en) * 2001-12-06 2003-06-12 Sherwood Timothy S. Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
US20060011197A1 (en) * 2002-09-16 2006-01-19 Hodson Peter D Aerosol dispensers and adaptors therefor
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US7128067B2 (en) 2000-04-27 2006-10-31 Philip Morris Usa Inc. Method and apparatus for generating an aerosol
US20060261094A1 (en) * 2003-04-22 2006-11-23 Thornhill Tristian R Dispensing apparatus
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers
US20080067199A1 (en) * 2004-09-16 2008-03-20 Hodson Peter D Valve Stems for Metered Dose Dispensing Valves
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20080185402A1 (en) * 2005-07-21 2008-08-07 Valois Sas Fluid Product Dispensing Valve
US20090114215A1 (en) * 2006-05-10 2009-05-07 Georg Boeck Atomizer and method of atomizing fluid
US7814900B2 (en) 2002-03-22 2010-10-19 Clinical Designs Limited Can fixture
WO2010145894A1 (en) 2009-06-17 2010-12-23 British American Tobacco (Investments) Limited Aerosol generator
JP2011504387A (ja) * 2007-11-22 2011-02-10 ジークフリート・ジェネリクス・インターナショナル・アクチェンゲゼルシャフト 粉末物質の吸入のための計量装置
US20110253138A1 (en) * 2008-10-08 2011-10-20 Astrazeneca Ab Inhaler with audible indicator means
WO2016079410A1 (fr) 2014-11-21 2016-05-26 Aptar France Sas Dispositif de distribution de produit fluide déclenché par l'inhalation.
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
WO2017044897A1 (en) * 2015-09-10 2017-03-16 Impel Neuropharma Inc. In-line nasal delivery device
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
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Cited By (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1566630B1 (de) * 1966-03-31 1971-10-28 Merck & Co Inc Geraet zur Abgabe dosierter Mengen eines medizinischen Wirkstoffs
US3636949A (en) * 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
US3598294A (en) * 1969-11-13 1971-08-10 Dart Ind Inc Inhalation-responsive aerosol dispenser
US3721240A (en) * 1970-11-10 1973-03-20 M Tamburri Mechanical smoking device
US3838686A (en) * 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US4130116A (en) * 1976-08-13 1978-12-19 Sigma Tau S.P.A. Industrie Farmaceutiche Riunite Pocket inhalator
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US5297542A (en) * 1989-06-22 1994-03-29 Raymond J. Bacon Aerosol dispensing device
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5184761A (en) * 1990-09-20 1993-02-09 Bespak Plc Dispensing apparatus
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5542410A (en) * 1991-03-05 1996-08-06 Aradigm Corporation Delivery of aeerosol medications for inspiration
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5520166A (en) * 1991-03-05 1996-05-28 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery system
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5608647A (en) * 1991-03-05 1997-03-04 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US5622162A (en) * 1991-03-05 1997-04-22 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5743252A (en) * 1991-03-05 1998-04-28 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US5755218A (en) * 1991-03-05 1998-05-26 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5822980A (en) * 1997-07-01 1998-10-20 Chen; Jack Device for reducing molecular pollutants in the gases from a combustion engine
DE29817001U1 (de) 1997-09-22 1998-12-24 Bespak plc, King's Lynn, Norfolk Druckausgabevorrichtung
FR2775668A1 (fr) * 1998-03-04 1999-09-10 Tebro Dispositif de distribution de produit fluide declenche par l'inhalation
US6397839B1 (en) 1998-03-04 2002-06-04 Tebro Dispensing device for fluid product activated by inhaling
WO1999044662A1 (fr) * 1998-03-04 1999-09-10 Tebro Dispositif de distribution de produit fluide declenche par l'inhalation
US7117867B2 (en) 1998-10-14 2006-10-10 Philip Morris Usa Aerosol generator and methods of making and using an aerosol generator
US6516796B1 (en) * 1998-10-14 2003-02-11 Chrysalis Technologies Incorporated Aerosol generator and methods of making and using an aerosol generator
US6557552B1 (en) 1998-10-14 2003-05-06 Chrysalis Technologies Incorporated Aerosol generator and methods of making and using an aerosol generator
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
US7128067B2 (en) 2000-04-27 2006-10-31 Philip Morris Usa Inc. Method and apparatus for generating an aerosol
US7373938B2 (en) 2000-12-22 2008-05-20 Philip Morris Usa Inc. Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US7173222B2 (en) 2000-12-22 2007-02-06 Philip Morris Usa Inc. Aerosol generator having temperature controlled heating zone and method of use thereof
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US7163014B2 (en) 2000-12-22 2007-01-16 Philip Morris Usa Inc. Disposable inhaler system
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6715487B2 (en) 2001-09-21 2004-04-06 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US20030079743A1 (en) * 2001-10-30 2003-05-01 Genova Perry A. Breath actuated dry powder inhaler
US6779520B2 (en) * 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US20030108342A1 (en) * 2001-12-06 2003-06-12 Sherwood Timothy S. Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US7814900B2 (en) 2002-03-22 2010-10-19 Clinical Designs Limited Can fixture
US20060011197A1 (en) * 2002-09-16 2006-01-19 Hodson Peter D Aerosol dispensers and adaptors therefor
US7497214B2 (en) 2002-09-16 2009-03-03 3M Innovative Properties Company Aerosol dispensers and adaptors therefor
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers
US20060261094A1 (en) * 2003-04-22 2006-11-23 Thornhill Tristian R Dispensing apparatus
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
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Publication number Publication date
DE1287260B (de) 1969-01-16
NL297349A (fi)
SE317467B (fi) 1969-11-17
GB1025245A (en) 1966-04-06

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