US20230212117A2 - Crystalline form of capsid protein assembly inhibitor containing n hetero five-membered ring, and application thereof - Google Patents

Crystalline form of capsid protein assembly inhibitor containing n hetero five-membered ring, and application thereof Download PDF

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Publication number
US20230212117A2
US20230212117A2 US17/764,519 US202017764519A US2023212117A2 US 20230212117 A2 US20230212117 A2 US 20230212117A2 US 202017764519 A US202017764519 A US 202017764519A US 2023212117 A2 US2023212117 A2 US 2023212117A2
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crystalline form
compound
formula
present application
ray powder
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Pending
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US17/764,519
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English (en)
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US20220363634A1 (en
Inventor
Yin Lu
Meng Guo
Mingtong HU
Yuan Li
Wangwei AO
Yinsheng ZHANG
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Assigned to CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. reassignment CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GUO, MENG, HU, Mingtong, AO, Wangwei, LI, YUAN, ZHANG, Yinsheng, LU, Yin
Publication of US20220363634A1 publication Critical patent/US20220363634A1/en
Publication of US20230212117A2 publication Critical patent/US20230212117A2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Definitions

  • the samples were completely exposed to experimental conditions of influential factors (40° C., 60° C., 75% RH, 92.5% RH, high temperature and high humidity (40° C., 75% RH)). Samples were taken for analysis on day 10 and day 30.
  • the samples were completely exposed to illumination (visible light of 1,200,000 Lux ⁇ hr, UV of 216 W ⁇ hr/m 2 ) at room temperature.

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
US17/764,519 2019-09-29 2020-09-28 Crystalline form of capsid protein assembly inhibitor containing n hetero five-membered ring, and application thereof Pending US20230212117A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910934549.0 2019-09-29
CN201910934549 2019-09-29
PCT/CN2020/118427 WO2021058002A1 (zh) 2019-09-29 2020-09-28 含有n杂五元环的衣壳蛋白装配抑制剂的晶型及其应用

Publications (2)

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US20220363634A1 US20220363634A1 (en) 2022-11-17
US20230212117A2 true US20230212117A2 (en) 2023-07-06

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US (1) US20230212117A2 (de)
EP (1) EP4036078A4 (de)
JP (1) JP2022549923A (de)
CN (1) CN114430736A (de)
AU (1) AU2020355384A1 (de)
CA (1) CA3156070A1 (de)
WO (1) WO2021058002A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7434166B2 (ja) 2018-03-30 2024-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｎ－複素環式５員環含有カプシドタンパク質のアセンブリの阻害剤、その医薬組成物および使用
SG11202012346YA (en) 2018-06-11 2021-01-28 Venatorx Pharmaceuticals Inc Hepatitis b capsid assembly modulators
CN118159266A (zh) * 2021-10-08 2024-06-07 正大天晴药业集团股份有限公司 包含衣壳蛋白抑制剂和逆转录酶抑制剂的药物组合

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201600522UA (en) * 2013-07-25 2016-02-26 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
MX367689B (es) * 2014-02-06 2019-09-02 Janssen Sciences Ireland Uc Derivados de sulfamoilpirrolamida y su uso como medicamentos para el tratamiento de la hepatitis b.
SG11201807569WA (en) * 2016-03-09 2018-10-30 Univ Emory Elimination of hepatitis b virus with antiviral agents
WO2019165374A1 (en) * 2018-02-26 2019-08-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
JP7434166B2 (ja) * 2018-03-30 2024-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｎ－複素環式５員環含有カプシドタンパク質のアセンブリの阻害剤、その医薬組成物および使用
SG11202012346YA (en) * 2018-06-11 2021-01-28 Venatorx Pharmaceuticals Inc Hepatitis b capsid assembly modulators
EA202092159A1 (ru) * 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение

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Publication number Publication date
AU2020355384A1 (en) 2022-05-05
US20220363634A1 (en) 2022-11-17
CN114430736A (zh) 2022-05-03
EP4036078A4 (de) 2023-09-06
CA3156070A1 (en) 2021-04-01
EP4036078A1 (de) 2022-08-03
WO2021058002A1 (zh) 2021-04-01
JP2022549923A (ja) 2022-11-29

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