US20220146403A1 - Microparticle measurement device, microparticle sorting device, microparticle measurement system, and microparticle sorting system - Google Patents

Microparticle measurement device, microparticle sorting device, microparticle measurement system, and microparticle sorting system Download PDF

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Publication number
US20220146403A1
US20220146403A1 US17/433,740 US202017433740A US2022146403A1 US 20220146403 A1 US20220146403 A1 US 20220146403A1 US 202017433740 A US202017433740 A US 202017433740A US 2022146403 A1 US2022146403 A1 US 2022146403A1
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United States
Prior art keywords
excitation light
microparticles
microparticle
light irradiation
objective lenses
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Pending
Application number
US17/433,740
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English (en)
Inventor
Yoshiki Okamoto
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Sony Group Corp
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Sony Group Corp
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Publication date
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Publication of US20220146403A1 publication Critical patent/US20220146403A1/en
Assigned to Sony Group Corporation reassignment Sony Group Corporation ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OKAMOTO, YOSHIKI
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B13/00Optical objectives specially designed for the purposes specified below
    • G02B13/14Optical objectives specially designed for the purposes specified below for use with infrared or ultraviolet radiation
    • G02B13/143Optical objectives specially designed for the purposes specified below for use with infrared or ultraviolet radiation for use with ultraviolet radiation
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00Simple or compound lenses
    • G02B3/0006Arrays
    • G01N15/149
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0065Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials biological, e.g. blood
    • G01N2015/0073Red blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0288Sorting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0294Particle shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/149Sorting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493Particle size
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497Particle shape

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
US17/433,740 2019-03-06 2020-01-16 Microparticle measurement device, microparticle sorting device, microparticle measurement system, and microparticle sorting system Pending US20220146403A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019040421A JP2020143991A (ja) 2019-03-06 2019-03-06 微小粒子測定装置、微小粒子分取装置、微小粒子測定システム及び微小粒子分取システム
JP2019-040421 2019-03-06
PCT/JP2020/001207 WO2020179237A1 (ja) 2019-03-06 2020-01-16 微小粒子測定装置、微小粒子分取装置、微小粒子測定システム及び微小粒子分取システム

Publications (1)

Publication Number Publication Date
US20220146403A1 true US20220146403A1 (en) 2022-05-12

Family

ID=72337515

Family Applications (1)

Application Number Title Priority Date Filing Date
US17/433,740 Pending US20220146403A1 (en) 2019-03-06 2020-01-16 Microparticle measurement device, microparticle sorting device, microparticle measurement system, and microparticle sorting system

Country Status (3)

Country Link
US (1) US20220146403A1 (ja)
JP (1) JP2020143991A (ja)
WO (1) WO2020179237A1 (ja)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8004661B2 (en) * 2008-06-30 2011-08-23 Microbix Biosystems Inc. Method and apparatus for sorting cells
US20120211679A1 (en) * 2010-08-20 2012-08-23 Bio-Rad Laboratories, Inc. Cytometry system with solid numerical-aperture-increasing lens
US20120238032A1 (en) * 2011-03-18 2012-09-20 International Business Machines Corporation Lab on a chip
US20130201322A1 (en) * 2010-08-18 2013-08-08 Nanoentek, Inc. Fluorescent microscope for observing multiple fluorescent images, fluorescent image surveying method using the same, and multiple fluorescent image observing system
US20130342838A1 (en) * 2012-06-22 2013-12-26 Azbil Corporation Optical particle detecting device and particle detecting method
US20140367315A1 (en) * 2011-12-29 2014-12-18 Danmarks Tekniske Universitet System for sorting microscopic objects using electromagnetic radiation
US20180188173A1 (en) * 2015-12-22 2018-07-05 University Of Maryland, College Park Cell classification based on mechanical signature of nucleus
US20190070608A1 (en) * 2017-09-06 2019-03-07 Hamamatsu Photonics K.K. Cell observation system and cell observation method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3218108B2 (ja) * 1993-02-10 2001-10-15 シスメックス株式会社 イメージングフローサイトメータ
JP4262380B2 (ja) * 1999-12-24 2009-05-13 オリンパス株式会社 光量測定装置
JP4756948B2 (ja) * 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
JP4251193B2 (ja) * 2006-05-23 2009-04-08 コニカミノルタセンシング株式会社 反射特性測定装置
JP2016012114A (ja) * 2014-06-02 2016-01-21 オリンパス株式会社 照明装置、これを有する顕微鏡装置及び顕微鏡観察方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8004661B2 (en) * 2008-06-30 2011-08-23 Microbix Biosystems Inc. Method and apparatus for sorting cells
US20130201322A1 (en) * 2010-08-18 2013-08-08 Nanoentek, Inc. Fluorescent microscope for observing multiple fluorescent images, fluorescent image surveying method using the same, and multiple fluorescent image observing system
US20120211679A1 (en) * 2010-08-20 2012-08-23 Bio-Rad Laboratories, Inc. Cytometry system with solid numerical-aperture-increasing lens
US20120238032A1 (en) * 2011-03-18 2012-09-20 International Business Machines Corporation Lab on a chip
US20140367315A1 (en) * 2011-12-29 2014-12-18 Danmarks Tekniske Universitet System for sorting microscopic objects using electromagnetic radiation
US20130342838A1 (en) * 2012-06-22 2013-12-26 Azbil Corporation Optical particle detecting device and particle detecting method
US20180188173A1 (en) * 2015-12-22 2018-07-05 University Of Maryland, College Park Cell classification based on mechanical signature of nucleus
US20190070608A1 (en) * 2017-09-06 2019-03-07 Hamamatsu Photonics K.K. Cell observation system and cell observation method

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Publication number Publication date
JP2020143991A (ja) 2020-09-10
WO2020179237A1 (ja) 2020-09-10

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