US20220125346A1 - Sensor inserter having introducer - Google Patents
Sensor inserter having introducer Download PDFInfo
- Publication number
- US20220125346A1 US20220125346A1 US17/514,193 US202117514193A US2022125346A1 US 20220125346 A1 US20220125346 A1 US 20220125346A1 US 202117514193 A US202117514193 A US 202117514193A US 2022125346 A1 US2022125346 A1 US 2022125346A1
- Authority
- US
- United States
- Prior art keywords
- sensor
- insertion assembly
- sensor insertion
- introducer
- actuator button
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003780 insertion Methods 0.000 claims abstract description 63
- 230000037431 insertion Effects 0.000 claims abstract description 63
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 21
- 239000008103 glucose Substances 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 20
- 230000006835 compression Effects 0.000 claims description 7
- 238000007906 compression Methods 0.000 claims description 7
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 230000000994 depressogenic effect Effects 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 26
- 230000000717 retained effect Effects 0.000 abstract description 8
- 230000007246 mechanism Effects 0.000 abstract description 5
- 239000012491 analyte Substances 0.000 description 58
- 238000012544 monitoring process Methods 0.000 description 21
- 238000004891 communication Methods 0.000 description 18
- 239000008280 blood Substances 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 17
- 239000000758 substrate Substances 0.000 description 13
- 238000005096 rolling process Methods 0.000 description 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
- 239000000853 adhesive Substances 0.000 description 9
- 230000001070 adhesive effect Effects 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000012545 processing Methods 0.000 description 7
- -1 CK-MB) Chemical compound 0.000 description 6
- 239000005020 polyethylene terephthalate Substances 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 5
- 108090001061 Insulin Proteins 0.000 description 5
- 229940125396 insulin Drugs 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000004804 winding Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 229920002635 polyurethane Polymers 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- 239000004642 Polyimide Substances 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229920001721 polyimide Polymers 0.000 description 3
- 229920006254 polymer film Polymers 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 238000000608 laser ablation Methods 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 239000012815 thermoplastic material Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 1
- 102100038358 Prostate-specific antigen Human genes 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 108090001027 Troponin Proteins 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940107161 cholesterol Drugs 0.000 description 1
- 229940015047 chorionic gonadotropin Drugs 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 229960000648 digitoxin Drugs 0.000 description 1
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- IXZISFNWUWKBOM-ARQDHWQXSA-N fructosamine Chemical compound NC[C@@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O IXZISFNWUWKBOM-ARQDHWQXSA-N 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 229910021397 glassy carbon Inorganic materials 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011540 sensing material Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000004447 silicone coating Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
Definitions
- the present disclosure relates to a sensor delivery unit. More particularly, the present disclosure relates to a sensor inserter having a safety member to impede actuation of the inserter.
- the present disclosure also relates to an introducer having a holding member configured to releasably retain a sensor, such as an analyte sensor.
- the introducer can further comprise a compressible member configured to tent the skin and puncture the skin to a reduced depth during insertion of a sensor.
- the present disclosure also relates to a method of arming the sensor delivery unit.
- Diabetes Mellitus is an incurable chronic disease in which the body does not produce or properly utilize insulin.
- Insulin is a hormone produced by the pancreas that regulates blood sugar (glucose).
- glucose blood sugar
- the pancreas does not produce sufficient insulin (a condition known as Type I Diabetes) or does not properly utilize insulin (a condition known as Type II Diabetes)
- the blood glucose remains in the blood resulting in hyperglycemia or abnormally high blood sugar levels.
- diabetes The vast and uncontrolled fluctuations in blood glucose levels in people suffering from diabetes cause long-term, serious complications. Some of these complications include blindness, kidney failure, and nerve damage. Additionally, it is known that diabetes is a factor in accelerating cardiovascular diseases such as atherosclerosis (hardening of the arteries), leading to stroke, coronary heart disease, and other diseases. Accordingly, one important and universal strategy in managing diabetes is to control blood glucose levels.
- the first step in managing blood glucose levels is testing and monitoring blood glucose levels by using conventional techniques, such as drawing blood samples, applying the blood to a test strip, and determining the blood glucose level using colorimetric, electrochemical, or photometric test meters.
- Another more recent technique for monitoring glucose levels is by using commercially available continuous glucose monitoring systems.
- a sensor is typically subcutaneously or transcutaneously positioned under the skin of a user.
- a sensor inserter assembly which can be preloaded with a sensor, is employed to insert the sensor through the skin of a user.
- a new sensor is generally implanted under the user's skin every three to seven days.
- a sensor insertion assembly includes an inserter housing, an introducer including a body portion having a proximal end and a distal end and a shaft portion comprising a channel and a distal end, the shaft portion extending downwardly from an edge of the body portion, the shaft portion including a holding member disposed along a length of the channel, the holding member configured to substantially releasably retain a sensor, an on-body electronics unit, wherein the introducer is configured for insertion of the sensor through an aperture in the on-body electronics unit prior to insertion through skin and a drive mechanism included in the inserter housing and operatively coupled to the introducer that drives the introducer and retained sensor through the skin.
- the introducer holding member may include one or more rolling members disposed along a length of the shaft portion, the rolling members configured to contact and releasably retain the sensor.
- the introducer rolling members may be configured to rotate.
- the sensor retained by the shaft portion of the introducer may be displaced from the shaft portion upon rotation of the rolling members.
- the introducer rolling members may be disposed within the channel.
- the introducer rolling members may be disposed within a sidewall of the channel.
- the introducer shaft portion may include an aperture formed in the channel, and the sensor may include a flange extending from an edge of the sensor, the flange disposed in the aperture formed in the channel.
- the aperture may include a section configured to be wider than the width of a sensor flange such that the sensor may be displaced from the shaft.
- the introducer holding member may comprise a sponge material disposed along the channel of the shaft portion, the sponge material configured to provide a soft interference fit with a sensor disposed in the shaft portion.
- the introducer shaft portion is substantially hollow.
- the introducer shaft portion may be configured to retain at least a portion of the sensor substantially subcutaneously when the shaft portion is removed from a skin layer.
- the introducer distal end may include a tapered end configured to pierce the skin layer and at least a portion of the sensor may be substantially retained within the shaft portion while the tapered end is piercing through the skin layer.
- the sensor may be substantially contemporaneously transcutaneously introduced through the skin layer when the tapered end of the shaft portion is transcutaneously introduced to the skin layer.
- the sensor includes an analyte sensor.
- the analyte sensor may be a glucose sensor.
- the introducer may be configured to position the analyte sensor in fluid contact with an analyte of a user.
- the introducer may include a compressible member having a distal end, the compressible member attached to a lateral side of the introducer shaft portion, wherein the distal end of the compressible member is distal to the distal end of the introducer shaft portion.
- the compressible member may be configured to retract to allow the sharp to penetrate skin of a user.
- FIG. 1 is a perspective view showing a sensor inserter and adhesive mount constructed in accordance with the disclosed subject matter
- FIG. 2 is a perspective view of the adhesive mount and sensor attached to the user's skin in accordance with the disclosed subject matter
- FIG. 3 is a perspective view of the transmitter attached to the adhesive mount in accordance with the disclosed subject matter
- FIG. 4 is an exploded perspective view of the embodiment of FIG. 1 ;
- FIG. 5 is a cross-sectional view of the inserter of FIG. 1 ;
- FIG. 6 is a schematic depiction of an introducer and sensor in accordance with the disclosed subject matter
- FIG. 7 is a is a schematic depiction of a shaft portion of the introducer in accordance with the disclosed subject matter
- FIG. 8 is a perspective view of a shaft portions having one or more holding member in accordance with the disclosed subject matter
- FIG. 9 is a sectional view of the shaft portion of FIG. 8 in accordance with the disclosed subject matter.
- FIG. 10 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter
- FIG. 11 is a perspective view of the shaft portion of FIG. 10 in accordance with the disclosed subject matter.
- FIG. 12 is a perspective view of a shaft portion having one or more holding members in accordance with the disclosed subject matter
- FIG. 13 is a sectional view of a shaft portion having one or more holding members in accordance with the disclosed subject matter in a first configuration
- FIG. 14 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration
- FIG. 15 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration
- FIG. 16 is a perspective view of the shaft portion of FIG. 15 in accordance with the disclosed subject matter.
- FIG. 17 is a perspective view of the shaft portion of FIG. 15 in accordance with the disclosed subject matter.
- FIGS. 18-20 are views of a shaft portion in accordance with the disclosed subject matter.
- FIG. 21 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration
- FIG. 22 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration
- FIG. 23 is a side view of a shaft portion comprising a compressible member in accordance with the disclosed subject matter in a second configuration
- FIG. 24 is an enlarged side view of a shaft portion of FIG. 23 in accordance with the disclosed subject matter in a second configuration
- FIG. 25 is a partial side view of a shaft portion of FIG. 23 in accordance with the disclosed subject matter in a second configuration
- FIG. 26 is a sectional view of a shaft portion of FIG. 23 in accordance with the disclosed subject matter in a second configuration
- FIG. 27 is a side view of a shaft portion of FIG. 23 in accordance with the disclosed subject matter in a second configuration
- FIG. 28-30 are schematic depictions of the introducer of FIGS. 23-27 depressing the skin and retracting to allow introducer sharp to pierce the skin in accordance with the disclosed subject matter;
- FIGS. 31-45 are perspective views of some embodiments of the safety member of the sensor inserter assembly in accordance with the disclosed subject matter
- FIG. 46 is a cross-sectional view of an inserter having a pin disposed against the shuttle of the inserter in accordance with the disclosed subject matter.
- FIGS. 47-49 illustrate a method of arming a sensor.
- analyte monitoring system Various exemplary embodiments of the analyte monitoring system and methods of the present disclosure are described in further detail below.
- the present disclosure is described primarily with respect to a glucose monitoring system, each aspect of the present disclosure is not intended to be limited to the particular embodiment so described. Accordingly, it is to be understood that such description should not be construed to limit the scope of the present disclosure, and it is to be understood that the analyte monitoring system can be configured to monitor a variety of analytes, as described below.
- section headers are merely for the convenience of the reader and are not to be taken as limiting the scope of the present disclosure in any way, as it will be understood that certain elements and features of the present disclosure have more than one function and that aspects of the present disclosure and particular elements are described throughout the specification.
- the present disclosure is generally directed to an analyte monitoring system including an apparatus, such as an inserter, configured to insert various devices into the body of a subject, such as for example, an analyte sensor, an infusion set, or a lancing device.
- an apparatus such as an inserter
- various devices such as for example, an analyte sensor, an infusion set, or a lancing device.
- Certain classes of analyte monitoring systems are provided in small, lightweight, battery-powered and electronically-controlled systems. Such systems may be configured to detect signals indicative of in vivo analyte levels using an electrochemical sensor, and collect such signals, with or without processing the signal. In some embodiments, the portion of the system that performs this initial processing may be configured to provide the raw or initially processed data to another unit for further collection and/or processing. Such provision of data may be effected, for example, via a wired connection, such as an electrical, or via a wireless connection, such as an IR or RF connection.
- Certain analyte monitoring systems for in vivo measurement employ a sensor that measures analyte levels in interstitial fluids under the surface of the subject's skin. These may be inserted partially through the skin or positioned entirely under the skin.
- a sensor in such a system may operate as an electrochemical cell.
- Such a sensor may use any of a variety of electrode configurations, such as a three-electrode configuration (e.g., with “working”, “reference” and “counter” electrodes), driven by a controlled potential (potentiostat) analog circuit, a two-electrode system configuration (e.g., with only working and counter electrodes), which may be self-biasing and/or self-powered, and/or other configurations.
- the sensor may be positioned within a blood vessel.
- the analyte sensor is in communication with a sensor control unit.
- an on-body unit sometimes refers to such a combination of an analyte sensor with such a sensor control unit.
- the analyte monitoring system may include an on-body unit including a sensor and a monitor unit. Exemplary embodiments of combination analyte sensor and sensor control unit configurations are further disclosed in, among others, U.S. patent application Ser. Nos. 12/873,301 and 11/530,473, now U.S. Pat. No. 9,398,882, the disclosures of each of which are incorporated herein by reference for all purposes.
- the on-body unit includes electronics configured to process the signal generated by the sensor and may further include a transmitter, transceiver, or other communications electronics to provide the processed data to the monitor unit via a communication link between the on-body unit and the monitor unit.
- Analyte monitoring systems include an adhesive mounting unit for adhering the on-body unit to a patient's skin.
- Exemplary mounting units can be found in, among others, U.S. patent application Ser. Nos. 12/873,302, 13/171,401, now U.S. Pat. No. 9,572,534, and 11/027,230, now U.S. Pat. No. 8,571,624, the disclosures of each of which are incorporated herein by reference for all purposes.
- mounting units include a base module in addition to an adhesive.
- the base module may be configured to physically couple with the on-body unit electronics for adhesive mounting of the on-body unit electronics to the patient. Examples of such coupling embodiments can be found in, among others, Ser. No.
- the mounting unit may also include a temperature sensing module to monitor the temperature of the skin of the patient, such as disclosed in Ser. No. 11/026,766, the disclosure of which is incorporated herein by reference.
- the on-body unit is placed on the skin of the patient prior to insertion of the sensor through the skin.
- the sensor may be inserted through an aperture in the on-body unit prior to penetration of skin.
- Exemplary disclosures of these embodiments can be found in, among others, U.S. Publication Nos. 2011/0213225, 2010/0198034, 2010/0324392, 2011/0319729, 2011/0288574, 2012/0010642 and 2013/0150691, the disclosures of which are incorporated herein by reference for all purposes.
- the monitor unit can include a display for displaying or communicating information to the user of the analyte monitoring system or the user's health care provider or another.
- the monitor unit is also referred to in this disclosure as a “receiver unit” or “receiver device”, or in some contexts, depending on the usage, as a “display unit,” “handheld unit,” or “meter”.
- receiver may also include buttons and/or scroll wheel which allow a user to interact with a user interface located on receiver.
- the monitor unit in some embodiments, may include, e.g., a mobile telephone device, a personal digital assistant, other consumer electronic device such as MP3 device, camera, radio, etc., or other communication-enabled data processing device.
- the monitor unit may perform data processing and/or analysis, etc. on the received analyte data to generate information pertaining to the monitored analyte levels.
- the monitor unit may incorporate a display screen, which can be used, for example, to display measured analyte levels, and/or audio component such as a speaker to audibly provide information to a user, and/or a vibration device to provide tactile feedback to a user. It is also useful for a user of an analyte monitor to be able to see trend indications (including the magnitude and direction of any ongoing trend), and such data may be displayed as well, either numerically, or by a visual indicator, such as an arrow that may vary in visual attributes, such as size, shape, color, animation, or direction.
- the receiver device may further incorporate an in vitro analyte test strip port and related electronics in order to be able to make discrete (e.g., blood glucose) measurements.
- on-body unit and monitor unit communicate via communications link (in this embodiment, a wireless RF connection). Communication may occur, e.g., via RF communication, infrared communication, Bluetooth® communication, Zigbee® communication, 802.1x communication, or WiFi communication, etc. In some embodiments, the communication may include an RF frequency of 433 MHz, 13.56 MHz, or the like. In some embodiments, a secondary monitor unit may be provided. A data processing terminal may be provided for providing further processing or review of analyte data.
- the analyte monitoring system may be a continuous analyte monitor (e.g., a continuous glucose monitoring system or CGM), and accordingly operate in a mode in which the communications via communications link has sufficient range to support a flow of data from the on-body unit to the monitor unit.
- the data flow in a CGM system is automatically provided by the on-body unit to the monitor unit. For example, in some embodiments no user intervention is required for the on-body unit to send the data to the monitor unit.
- the on-body unit provides the signal relating to analyte level to the receiving unit 300 on a periodic basis.
- the signal may be provided, e.g., automatically sent, on a fixed schedule, e.g., once every 250 ms, once a second, once a minute, etc.
- the signal is provided to the monitor unit upon the occurrence of an event, e.g., a hyperglycemic event or a hypoglycemic event, etc.
- on-body unit may further include local memory in which it may record “logged data” or buffered data collected over a period of time and provide the some or all of the accumulated data to monitor unit from time-to-time.
- a separate data logging unit may be provided to acquire periodically received data from on-body unit.
- Data transmission may be one-way communication, e.g., the on-body unit provides data to the monitor unit without receiving signals from the monitor unit. In some embodiments, two-way communication is provided between the on-body unit and the monitor unit.
- the analyte monitoring system includes a sensor which obtains an analyte signal which is provided to the monitor unit “on demand.”
- the monitor unit requests a signal from the on-body unit, or the on-body unit may be activated to send signal upon activation to do so.
- one or both of the on-body unit and monitor unit may include a switch activatable by a user or activated upon some other action or event, the activation of which causes analyte-related signal to be transferred from the on-body unit to the monitor unit.
- the monitor unit is placed in close proximity with a transmitter device and initiates a data transfer, either over a wired connection, or wirelessly by various means, including, for example various RF-carried encodings and protocols and IR links.
- the signal relating to analyte level is instantaneously generated by the analyte sensor upon receipt of the request, and provided to the monitor unit as requested, and/or the signal relating to analyte level is periodically obtained, e.g., once every 250 ms, once a second, once a minute, etc.
- an analyte signal is provided to the monitor unit.
- the signal provided to the monitor unit is or at least includes the most recent analyte signal(s).
- additional data is provided to the monitor unit “on demand.”
- analyte trend data may be provided.
- Such trend data may include two or more analyte data points to indicate that analyte levels are rising, falling, or stable.
- Analyte trend data may include data from longer periods of time, such as, e.g., several minutes, several hours, several days, or several weeks.
- analyte monitoring systems may further include medication infusion devices integrated therewith.
- medication infusion devices integrated therewith. Examples of such embodiments can be found in, among others, U.S. patent application Ser. No. 11/552,065, now U.S. Pat. No. 9,259,175, and Ser. No. 12/032,593, now U.S. Pat. No. 9,636,450, the disclosures of each of which are incorporated herein by reference for all purposes.
- the sensor in accordance with one embodiment of the present disclosure, can be configured to detect and monitor an analyte of interest present in a biological sample of a user.
- the biological sample can be a biological fluid containing the analyte of interest, such as (but not limited to) interstitial fluid, blood, and urine.
- the analyte of interest can be one or more analytes including acetyl choline, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase (e.g., CK-MB), creatine, DNA, fructosamine, glucose, glutamine, growth hormones, hormones, ketones, lactate, peroxide, prostate-specific antigen, prothrombin, RNA, thyroid stimulating hormone, and troponin.
- CK-MB creatine kinase
- the analyte monitoring system can be configured to monitor the concentration of drugs, such as, for example, antibiotics (e.g., gentamicin, vancomycin, and the like), digitoxin, digoxin, theophylline, warfarin, and the like.
- antibiotics e.g., gentamicin, vancomycin, and the like
- digitoxin digoxin
- theophylline e.g., gentamicin, vancomycin, and the like
- warfarin e.g., warfarin, and the like.
- the senor is physically positioned in or on the body of a user whose analyte level is being monitored by an insertion device.
- the sensor can be configured to continuously sample the analyte level of the user and convert the sampled analyte level into a corresponding data signal for transmission by the transmitter.
- the sensor is implantable into a subject's body for a period of time (e.g., three days, five days, seven days, etc.) to contact and monitor an analyte present in the biological fluid.
- a new sensor must be used typically every three to seven days.
- the senor comprises a substrate, one or more electrodes, a sensing layer and a barrier layer, as described below and disclosed in U.S. Pat. Nos. 6,284,478 and 6,990,366, the disclosures of which are incorporated by reference in their entirety herein for all purposes.
- the sensor includes a substrate.
- the substrate is formed from a relatively flexible material. Suitable materials for a flexible substrate include, for example, non-conducting plastic or polymeric materials and other non-conducting, flexible, deformable materials.
- Suitable plastic or polymeric materials include thermoplastics such as polycarbonates, polyesters (e.g., Mylar® and polyethylene terephthalate (PET)), polyvinyl chloride (PVC), polyurethanes, polyethers, polyamides, polyimides, or copolymers of these thermoplastics, such as PETG (glycol-modified polyethylene terephthalate).
- the sensor includes a relatively rigid substrate. Suitable examples of rigid materials that may be used to form the substrate include poorly conducting ceramics, such as aluminum oxide and silicon dioxide. Further, the substrate can be formed from an insulating material. Suitable insulating materials include polyurethane, Teflon (fluorinated polymers), polyethyleneterephthalate (PET, Dacron) or polyimide.
- the substrate can include a distal end and a proximal end.
- the distal and proximal ends have different widths.
- the distal and proximal ends have the same width.
- the proximal end of the sensor remains above the skin surface.
- the distal end of the substrate may have a relatively narrow width.
- sensors intended to be positioned at least partially into the tissue of a user's body at can be configured to have narrow distal end or distal point to facilitate the insertion of the sensor.
- a distal end of the sensor which is to be implanted into the user has a width of 2 mm or less, preferably 1 mm or less, and more preferably 0.5 mm or less.
- the sensor substrate distal end is constructed of material and shape to facilitate insertion of the distal end of the sensor through the skin of a patient without the use of an introducer sharp.
- a plurality of electrodes can be disposed near the distal end of sensor.
- the electrodes include working electrode, counter electrode and reference electrode. Other embodiments, however, can include a greater or fewer number of electrodes.
- Each of the electrodes is formed from conductive material, for example, a non-corroding metal or carbon wire.
- Suitable conductive materials include, for example, vitreous carbon, graphite, silver, silver-chloride, platinum, palladium, or gold.
- the conductive material can be applied to the substrate by various techniques including laser ablation, printing, etching, silk-screening, and photolithography.
- each of the electrodes is formed from gold by a laser ablation technique.
- the sensor can include conductive traces extending from electrodes to corresponding, respective contacts to define the sensor electronic circuitry.
- an insulating substrate e.g., dielectric material
- electrodes are arranged in a stacked orientation (i.e., insulating substrate disposed between electrodes).
- the electrodes can be arranged in a side by side orientation (not shown), as described in U.S. Pat. No. 6,175,752, the disclosure of which is incorporated by reference in its entirety herein for all purposes.
- the sensor can include a sensing material having one or more components designed to facilitate the electrolysis of the analyte of interest.
- the components may be immobilized on the working electrode.
- the components of the sensing layer may be immobilized within or between one or more membranes or films disposed over the working electrode or the components may be immobilized in a polymeric or sol-gel matrix. Further aspects of the sensor are described in U.S. Pat. Nos. 5,262,035, 5,264,104, 5,264,105, 5,320,725, 5,593,852, and 5,665,222, each of which is incorporated by reference in its entirety herein for all purposes.
- the senor is a self-powered analyte sensor, which is capable of spontaneously passing a currently directly proportional to analyte concentration in the absence of an external power source.
- Any exemplary sensor is described in U.S. patent application Ser. No. 12/393,921, filed Feb. 26, 2009, which is hereby incorporated by reference in its entirety herein for all purposes.
- an inserter is provided.
- the object to be inserted into the subject can be, for example, an analyte sensor as described above.
- other objects such as but not limited to an infusion set, or lancing device can be inserted.
- the sensor inserter assembly 100 includes a sensor (not shown) preloaded within inserter 110 .
- the user After preparing an insertion site on the skin of a user, the user removes an upper liner 116 and lower liner 118 from an adhesive mount 112 to expose the bottom surface and a portion of the top surface of an adhesive tape located on the bottom surface of the mount 112 .
- Mount 112 with inserter 110 attached, is then applied to the user's skin at the insertion site.
- the inserter includes an actuator button 124 to be pressed causing inserter 110 to fire, thereby inserting sensor 114 (not shown in FIG. 1 ) into the user's skin S.
- the inserter 110 includes a safety member to impede actuation of the inserter as described below.
- Mount 112 may be configured to receive inserter 110 in only a single configuration, thus ensuring proper alignment of the inserter 110 on the mount. Exemplary embodiments of mount and inserter configured for proper alignment can be found in, among others, U.S. patent application Ser. Nos. 11/380,883, and 11/535,983, now U.S. Pat. No. 7,697,967, the disclosures of each of which are incorporated herein by reference for all purposes.
- inserter 110 is removed from mount 112 by pressing release tabs 126 on opposite sides of inserter 110 and lifting inserter 110 away from mount 112 .
- FIG. 7 Further details of the inserter assembly 100 are provided in U.S. Pat. No. 7,381,184, which is incorporated by reference in its entirety herein for all purposes.
- the inserter maybe integrated with the mount, wherein after insertion of the sensor through the skin of the patient, the sensor electronics unit is slid into place on the mount, while the inserter remains part of the mount. Exemplary embodiments are disclosed in, among others, U.S. patent application Ser. No. 11/216,932, now U.S. Pat. No. 7,731,657, Ser. Nos.
- sensor electronics unit 130 can be slid into place, as illustrated in FIG. 3 .
- the circuitry of sensor electronics unit 130 makes electrical contact with the contacts on sensor 114 after sensor electronics unit 130 is fully seated on mount 112 .
- mount 112 , together with sensor 114 , and sensor electronics unit 130 comprises an on-body unit.
- sensor electronics unit 130 may include communications circuitry, such as a transmitter, transceiver, or the like, for communicating with additional equipment. For example, once initialization and synchronization procedures are completed, electrochemical measurements from sensor 114 can be sent, e.g., wirelessly from sensor electronics unit 130 to a monitor unit, such as portable receiver 132 , as shown in FIG. 3 .
- Sensor 114 , mount 112 and sensor electronics unit 130 remain in place on the user for a predetermined period, currently envisioned to be several hours, to several days, e.g., about three days, about five days, about seven days, etc. After expiration of the lifetime of the sensor, these components are then removed so that sensor 114 and mount 112 can be properly discarded. The entire procedure above can then be repeated with a new inserter 110 , sensor 114 and mount 112 .
- the sensor electronics unit 130 and receiver 132 are durable and are reused.
- the inserter assembly 100 can be assembled as shown from the following components: e.g., housing 134 , actuator button 124 , drive spring 136 , shuttle 138 , introducer sharp 140 , sensor 114 , retraction spring 142 , inserter base 144 , upper liner 116 , mounting unit 112 , adhesive tape 120 , and lower liner 118 .
- Sensor 114 has a main surface 146 slidably mounted between U-shaped rails 148 of introducer sharp 140 .
- Introducer sharp 140 can be mounted to face 154 of shuttle 138 , such as with adhesive, heat stake or ultrasonic weld.
- U.S. patent application Ser. No. 11/216,932, now U.S. Pat. No. 7,731,657, Ser. No. 11/617,698, now U.S. Pat. No. 8,545,403, and Ser. No. 11/535,983, now U.S. Pat. No. 7,697,967 disclose additional embodiments of sensor introducer sharps and insertion devices, the disclosures of which is incorporated herein by reference.
- shuttle 138 can be slidably and non-rotatably constrained on base 144 by arcuate guides 160 .
- the shuttle can be generally formed by an outer ring 162 and an inner cup-shaped post 164 connected by two bridges 166 .
- Bridges 166 can be configured to slide between the two slots 168 formed between guides 160 and allow shuttle 138 to travel along guides 160 without rotating.
- Retraction spring 142 can be captivated at its outer circumference by guides 160 , at its bottom by the floor 170 ( FIG. 5 ) of base 144 , at its top by bridges 166 , and at its inner circumference by the outer surface of shuttle post 164 .
- Drive spring 136 is captivated at its bottom and outer circumference by the inside surface of shuttle post 164 , at its top by the ceiling 172 ( FIG. 5 ) inside actuator button 124 , and at its inner circumference by stem 174 depending from ceiling 172 .
- drive spring 136 When drive spring 136 is compressed between actuator button 124 and shuttle 138 it can urge shuttle 138 towards base 144 .
- retraction spring 142 When retraction spring 142 is compressed between shuttle 138 and base 144 , it urges shuttle 138 towards actuator button 124 .
- the actuator button 124 is slidably received within housing 134 from below and resides in opening 176 at the top of housing 134 with limited longitudinal movement.
- Arms 178 on each side of actuator button 124 can be configured to travel in channels 180 along the inside walls of housing 134 , as best seen in FIG. 5 .
- Longitudinal movement of actuator button 124 can be limited in one direction by the base 182 of arms 178 contacting the edge of opening 176 at the top of housing 134 , and in the other direction by the distal ends 184 of arms 178 contacting stops 186 in channels 180 .
- Slots 188 are preferably provided in the top of housing 134 for ease of housing manufacture and so tools can be inserted to inwardly compress arms 178 beyond stops 186 to allow actuator button 124 to be removed from housing 134 if needed.
- housing 134 is snapped into place on base 144 .
- Base 144 is held onto housing 134 by upper base barbs 190 that engage upper openings 192 in housing 134 , and lower base barbs 194 that engage lower openings 192 in housing 134 .
- an introducer 440 which comprises a body portion 401 and a shaft portion 405 .
- Introducer 440 is substantially identical to introducer 140 , and useful with an inserter, such as inserter assembly 100 described hereinabove, with the differences illustrated in the accompanying figures, and described herein.
- the shaft portion 405 can include a substantially sharp distal edge segment 403 to contact and pierce the skin of a user for transcutaneous placement of the sensor through the user's skin S.
- the sensor 114 is retained within the shaft portion 405 of the introducer 440 and is configured to be held in position during insertion of the sensor through the user's skin by the substantially hollow cylindrical shape of the shaft portion 405 , as illustrated in FIG. 6 .
- the tip of the analyte sensor 114 can be retained at the distal edge segment 403 of the introducer 440 during the subcutaneously or transcutaneous positioning of the sensor 114 through the user's skin.
- the sensor 114 is positioned within the substantially hollow shaft portion 405 of the introducer 440 .
- the distal edge segment 403 of the introducer 440 is configured to first pierce through the user's skin, and guide sensor retained in the shaft portion 405 of the introducer 440 through the pierced skin of the user. After placement of the sensor 114 at the desired location under the skin, the introducer 440 can be retracted from the user, leaving the sensor 114 in place.
- a radial configuration 404 of the shaft portion 405 is configured to guide the removal of the introducer 440 from the pierced skin.
- the shaft portion includes one or more holding members configured to retain the sensor in the introducer.
- the shaft portion 405 of the introducer 440 may have a ribbed configuration to provide additional friction fit during the insertion of the introducer and sensor through the skin of the user.
- the holding member can include various configurations, as depicted in FIGS. 8 to 31 .
- the shaft portion 405 may include one or more rolling members 406 .
- the rolling members 406 can include for example rollers, balls, or wheels. In some embodiments, the rolling members 406 are disposed within the channel or wall of the shaft portion 405 .
- the rolling members 406 are configured to retain the sensor 114 in the introducer 140 by friction forces prior to insertion of the sensor 114 into the user's body. During the insertion process, the rolling members 406 can turn or rotate to displace the sensor 114 from the introducer shaft 405 during the insertion process. When the sensor 114 is placed at the desired depth and caught in the mount as part of the insertion (e.g., by hook, clamp or gripper), the rolling members 406 rotate from the friction from the sensor 114 as the introducer exits back into the inserter.
- the shaft portion 405 of the introducer 140 and the sensor 114 comprise a magnet 408 or magnetized area 409 , such that magnetic forces retain the sensor within the introducer.
- the magnetic material can be any material that will provide magnetic forces including, but not limited to, low grade stainless steel, carbon ink, and the like.
- the shaft or the sensor can be doped with magnetic metal.
- the magnet can be disposed along the channel of the shaft portion.
- magnetic material can be embedded on the surface of the sensor. Further, a magnet or a magnetized area is fit into the sharp to hold the sensor in place. Release of the magnetic force can occur when the shaft portion 405 is removed as part of the insertion process of the sensor delivery unit.
- the holding member comprises a sheath 407 disposed coaxially about the shaft portion 405 .
- the sheath 407 can comprise one or more perforations along a perforation line 410 disposed along a length of the sheath.
- the sheath can be a tear away member.
- the sheath comprises a polymer film.
- the polymer film can be attached to an outer surface of the shaft portion. Suitable materials for the sheath include polyimide, Pebax, polyethylene, Nylon, PTFE, polyester, and polyurethane.
- the shaft portion 405 can include one or more windings 411 configured to releasably retain the sensor 114 .
- the windings are generally a wound member 411 having the capability to unwind, as illustrated in FIG. 14 . While the winding 411 is in the wound configuration, it applies an interference against the sensor body to retain the sensor 114 .
- the sensor can be displaced from the shaft portion 405 upon unwinding the one or more windings.
- the windings comprise wound rolls of polymer film.
- the shaft portion 405 of the introducer 140 includes a substantially longitudinal opening 412 , as shown in FIGS. 15-17 .
- the sensor 114 can include a flange 413 disposed along an edge of the sensor body 114 to communicate through the longitudinal opening 412 .
- the engagement of the longitudinal opening 412 and the flange 413 provide an interference fit to retain the sensor 114 .
- the slot includes a distal section 412 B configured to be wider than the width of a proximal section 412 A, and sufficiently wide such that the sensor flange 413 may be displaced from the shaft when the flange becomes disposed in the wider section of the opening 412 , for example during the insertion process as the sensor travels towards an insertion position.
- the longitudinal opening 412 can be provided with a greater width at a distal section to allow the introducer 140 to be completely de-coupled from the sensor 114 retained within the shaft portion 405 during the placement thereof, so that the introducer 140 may be removed completely from the user, while leaving in place the sensor 114 .
- the sensor 114 can be configured to include a pin 415 extending from a lateral end of the sensor body. Similar to the flange member described above, the pin can engage a slot 412 ′ formed in the introducer so as to retain the sensor in the introducer. In some embodiments, the pin can be configured as a hinge member 416 .
- the holding member can include a sponge material 417 disposed along the channel of the shaft portion 405 , as shown in FIG. 21 .
- the sponge material 417 can be configured to provide a soft interference fit with a sensor 114 disposed in the shaft portion 405 and may comprise polyurethane, polyether, polystyrene, or isoprene foams.
- the foams can be attached via adhesive, or applied during the lubricious coating process (i.e., a silicone coating used to reduce friction and make insertion more smooth).
- the shaft 405 is provided with a diaphragm 418 , such as a thin, semi-rigid membrane housed along a portion of the channel.
- the diaphragm can include an opening 419 to receive and retain the sensor, as shown in FIG. 22 .
- the diaphragm 418 may be molded or cast polymer (silicone, urethane or TPE) plug or insert with a series of slits or webbing similar to an iris. Or it could be a type of a duckbill valve.
- the diaphragm 418 is fixed (molded or glued) to the inner diameter of the introducer.
- the diaphragm 418 may be rigid enough to hold the sensor but flexible to open when the senor is captured during insertion.
- the introducer 440 may be configured to reduce the insertion and extraction forces through the user's skin, thus reducing trauma to the skin.
- the introducer 440 can be configured to include a compressible member 518 attached to a lateral side of the introducer 440 , as illustrated in FIGS. 23-24 .
- the compressible member 518 can include a first section, or barrel 519 , and a second section, or plunger 520 , as shown in FIG. 23 .
- the first section 519 can include a compressible body.
- the compressible body can include a spring, such as a compression spring 522 (illustrated in dashed lines).
- the first section 519 includes a housing comprising the spring.
- the springs may be helical compression springs having variable pitch and compression rate.
- the shape of the spring can be straight, hourglass, conical or barrel.
- a controlled friction can be used to allow a plunger 520 to move inside the barrel 519 at a set force. When the predetermined “break force” is reached, the plunger 520 can move.
- the shaft 405 of the introducer 440 is attached in some embodiments to the housing of the compression member 518 .
- the second section 520 of the compressible member 518 is non-compressible, but retractable.
- the second section 520 can be formed from a solid thermoplastic member.
- the first section 519 can be configured to receive the second section 520 .
- the compressible member 518 can be compressed upon retraction of the second section 520 within the first portion housing 519 .
- the first and second sections can have a telescoping relationship, such that the sliding engagement of the second member upwardly into the first member causes compression of the compressible member, as illustrated in FIG. 25 .
- a first position of second section 520 is illustrated in dashed line and the second position of the second section 520 is illustrated in solid line.
- the compression of the compressible member 518 by the retraction of the second member 520 causes the distal edge 403 of the introducer shaft, i.e., the sharp, to contact and pierce through the skin of the user.
- the compressible member 518 contacts the skin S of a user.
- the second section 520 of the compressible member contacts the skin S prior to the introducer edge 403 because the distal end of the compressible member 518 is initially distal to the introducer distal end 403 . See FIGS. 28-29 .
- the second member 520 can depress the skin S from the pressure of the contact between the second section 520 and the skin S. As shown in FIG.
- the distal end 403 of the introducer 440 then makes contact with the skin S, as the compressible section 518 compressed upon retraction of the second section 520 upwardly to allow the distal end 403 of the introducer 440 to puncture the skin S and proceed to insert the sensor 114 (not shown in FIG. 30 ).
- the compressible member 518 allows control of the depth of the puncture. By maintaining a relatively small skin puncture, it is possible to reduce the amount of potential bleeding during the skin piercing process for subcutaneous or transcutaneous sensor placement, and likewise the result is less bruising and also faster healing.
- the edge segment 403 of the introducer 440 guides the sensor 114 into and through the skin puncture.
- the edge segment 403 may be sharpened and polished to facilitate a smooth puncture and a clean cut through the user's skin.
- the substantially hollow shaft portion can be configured to minimize the necessary force to deploy the introducer, and minimize pain and skin trauma during puncture and removal of the introducer from the skin.
- the edge segment 403 of the introducer 440 includes a substantially sharp and angled tip (as shown in FIG. 6 ) for piercing the user's skin.
- the edge segment 403 of the introducer 440 can be sharp and tapered to facilitate skin piercing while minimizing skin trauma. In this manner, it is possible to minimize the size of the skin wound at the piercing site where the introducer 440 is placed through the skin, and thus, the user will likely experience a faster healing time.
- actuator 124 described hereinabove can be provided with a safety member, such as safety member 625 , 625 ′, 625 ′′, 634 , 636 , 650 , configured to impede actuation of the actuator, by for example, preventing the actuator button 124 from being depressed. Accordingly, the safety member can avoid accidental firing of inserter assembly 100 .
- the safety member can take the form of various configurations.
- the safety member 625 can comprise a pin or a plug member, such as, but not limited to, a “grenade” pin, or molded plug, as disclosed in FIGS. 31-36 .
- the actuator 124 can include one or more apertures or slots (not shown) extending through the actuator 124 through which the safety pin 628 is disposed.
- the safety member can further include a pull tab 626 for ease of removal to deactivate the safety.
- the actuator 124 can include one or more apertures or slots (not shown) extending through the actuator 124 through which the safety pin 628 ′ is disposed.
- the safety member can further include a pull tab 626 ′ for ease of removal to deactivate the safety.
- the safety member 625 ′′ can include a body having a first end 630 and a second end 632 configured to form an L-shaped body, as shown in FIGS. 35-36 .
- the L-shaped safety member includes, as part of its unitary body a pull tab 630 that protrudes from the slot or aperture formed in actuator 124 .
- the first or second ends of the L-shaped body can define a pull tab for deactivation of the safety.
- the safety member comprises a D-ring 634 , as shown in FIGS. 37-38 .
- the D ring 634 can be formed from plastic or a metal.
- the actuator can include a slot having an opening in communication with the exterior of the actuator. The D-ring can be slid and disposed in the slot, as shown in FIG. 38 .
- the safety member can comprise a press clip 636 , as illustrated in FIGS. 40-42 .
- the press clip 636 in some embodiments, comprises first and second legs 638 , 640 connected to each other at a bridging member 642 .
- the press clip 636 includes first and second feet 644 , 646 configured to be disposed in one or more apertures formed in the actuator, as illustrated in FIGS. 41 and 42 .
- the configuration of clip 636 provides an outward force, as indicated by arrows 40 .
- the press clip 646 can be disposed in one or more apertures formed on an interior surface of the actuator 124 as illustrated in FIG. 42 .
- the safety member can comprise a press clip 650 , as illustrated in FIGS. 43-45 .
- the press clip 650 in some embodiments, comprises first and second legs 652 , 654 connected to each other at a bridging member 656 .
- the press clip 650 includes first and second feet 658 , 660 configured to be disposed in one or more apertures formed in the actuator 124 , as illustrated in FIGS. 44 and 45 .
- the configuration of clip 650 provides an inward force, as indicated by arrows 43 .
- the press clip 650 can be disposed in one or more apertures formed on an exterior surface of the actuator 124 as illustrated in FIG. 45 .
- the safety member can be formed from a variety of materials.
- the material can be a thermoplastic material, such as TPE materials or a metal.
- the thermoplastic material has a shore hardness of about 40 to 50.
- plastic, metal, wood, or paper can be formed in the shape of a pin as long as it could serve to prevent the downward movement of the button.
- tabs 122 Upon deactivation of the safety member such as by removal of the safety member, tabs 122 , as illustrated in FIGS. 1 and 5 , can be squeezed inward just enough to clear the rim 204 of opening 176 while pressing the actuator button 124 down to fire the inserter. Alternatively, tabs 122 can be squeezed further inward so that barbs on the inside edges can engage catches located on a center portion of actuator button 124 by simply pressing down on the actuator button 124 .
- shuttle 138 is provided with laterally extending barbed fingers 212 which travel in channels 180 along the inside walls of housing 134 .
- barbed fingers 212 momentarily deflect inward and then snap outward again to catch on stops 186 .
- drive spring 136 is compressed and urging shuttle 138 towards base 144 , but barbed fingers 212 catching on stops 186 prevent such travel.
- the sensor inserter assembly 110 in its unarmed position can include a pin 728 member, such as a plastic tubular member, disposed in the firing path of the inserter.
- the pin 728 is configured to butt against the bottom of the shuttle 138 and protrude from the bottom surface of the sensor inserter assembly, as shown in FIGS. 46 and 47 .
- the pin 728 can keep the shuttle from bouncing on the return spring.
- a method is provided to arm the sensor inserter assembly.
- the sensor can be armed by the user prior to insertion of a sensor.
- the method includes, as shown in FIGS. 47-49 , contacting the sensor inserter assembly against a surface, such as a table top.
- the contact of the pin 728 with a relatively hard surface causes the pin to be pushed upwardly the retraction position such that the barbed fingers 212 are moved to a cocked position, as described above.
- the sensor inserter assembly can be configured such that an audible click is sounded when the barbed fingers move to position.
- the actuator button 124 moves upwardly to the cocked position. After the barbed fingers and the actuator are armed, the pin 728 is removed from the sensor insertion assembly and the sensor inserter assembly is armed and ready to use.
- the user arms the drive mechanism, such as the first spring, to generate the sufficient inertial force needed to drive the introducer and the sensor through the user's skin.
- the introducer and the sensor are provided in a fully assembled sensor inserter assembly package within a transmitter mounting unit.
- the drive mechanism is armed, and the user places the transmitter mount on the surface of the user's skin where the user wishes to place the sensor.
- the sensor insertion assembly may be self-arming, allowing for ease of insertion of the sensor. Examples of such embodiments can be found in, among others, U.S. patent application Ser. No. 12/129,573, now U.S. Pat. No. 8,613,703, the disclosure of which is incorporated herein by reference for all purposes.
- Such embodiments include insertion devices utilizing variable speed insertion, by varying the speed of the shuttle through the insertion device; shape memory alloy insertion devices, wherein the introducer is constructed of a shape memory alloy that changes shape from a compressed state to a rigid insertion shape upon activation of the shape memory alloy; and coupleable insertion devices and on-skin mounting units, wherein the systems are configured such that the insertion device and on-skin mounting unit can only be coupled in a position such that the insertion device is aligned for proper sensor insertion.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
- The present application is a continuation of U.S. patent application Ser. No. 16/263,155 filed Jan. 31, 2019, which is a continuation of U.S. patent application Ser. No. 14/040,674 filed Sep. 28, 2013, now U.S. Pat. No. 10,226,207, which is a continuation-in-part of U.S. patent application Ser. No. 12/893,974 filed Sep. 29, 2010, now abandoned, which claims priority to U.S. Provisional Application No. 61/246,825 filed Sep. 29, 2009, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/795,634 filed Jun. 7, 2010, now U.S. Pat. No. 8,602,991, which is a continuation of U.S. patent application Ser. No. 11/216,932 filed Aug. 30, 2005, now U.S. Pat. No. 7,731,657, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/022,616 filed Feb. 7, 2011, now U.S. Pat. No. 10,194,863, which is a continuation of U.S. patent application Ser. No. 11/240,257 filed Sep. 30, 2005, now U.S. Pat. No. 7,883,464, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/552,065 filed Oct. 23, 2006, now U.S. Pat. No. 9,259,175, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/129,573 filed May 29, 2008, now U.S. Pat. No. 8,613,703, which claims priority to U.S. Provisional Application No. 60/941,060 filed May 31, 2007, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/870,818 filed Aug. 28, 2010, now abandoned, which claims priority to U.S. Provisional Application No. 61/238,159 filed Aug. 29, 2009, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/873,301 filed Aug. 31, 2010, now abandoned, which claims priority to U.S. Provisional Application No. 61/238,494 filed Aug. 31, 2009, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/873,302 filed Aug. 31, 2010, now abandoned, which claims priority to U.S. Provisional Application No. 61/238,537 filed Aug. 31, 2009 and 61/238,483 filed Aug. 31, 2009, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/171,401 filed Jun. 28, 2011, now U.S. Pat. No. 9,572,534, which claims priority to U.S. Provisional Application No. 61/359,816 filed Jun. 29, 2010, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/434,804 filed Mar. 29, 2012, now U.S. Pat. No. 9,743,862, which claims priority to U.S. Provisional Application No. 61/470,454 filed Mar. 31, 2011, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/026,766 filed Dec. 29, 2004, now abandoned, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/252,118 filed Oct. 3, 2011, now U.S. Pat. No. 9,364,149, which is a continuation of U.S. patent application Ser. No. 11/365,334 filed Feb. 28, 2006, now U.S. Pat. No. 8,029,441, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/970,397 filed Aug. 19, 2013, now U.S. Pat. No. 9,480,421, which is a continuation of U.S. patent application Ser. No. 11/240,259 filed Sep. 30, 2005, now U.S. Pat. No. 8,512,243, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/530,473 filed Sep. 10, 2006, now U.S. Pat. No. 9,398,882, which is a continuation-in-part of U.S. patent application Ser. No. 11/240,259 filed Sep. 30, 2005, now U.S. Pat. No. 8,512,243, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/380,883 filed Apr. 28, 2006, now abandoned, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 13/717,501 filed Dec. 17, 2012, now U.S. Pat. No. 8,862,198, which is a continuation of U.S. patent application Ser. No. 11/530,472 filed Sep. 10, 2006, now U.S. Pat. No. 8,333,714, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/192,773 filed Jul. 29, 2005, now abandoned, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/552,072 filed Oct. 23, 2006, now U.S. Pat. No. 9,788,771, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/027,230 filed Dec. 29, 2004, now U.S. Pat. No. 8,571,624, the disclosure of which is incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/895,015 filed Sep. 30, 2010, now U.S. Pat. No. 9,351,669, which claims priority to U.S. Provisional Application No. 61/247,516 filed Sep. 30, 2009, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 11/617,698 filed Dec. 28, 2006, now U.S. Pat. No. 8,545,403, which claims priority to U.S. Provisional Application No. 60/754,870 filed Dec. 28, 2005, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/571,349 filed Sep. 30, 2009, now U.S. Pat. No. 8,852,101, which is a continuation of U.S. patent application Ser. No. 11/535,983 filed Sep. 28, 2006, now U.S. Pat. No. 7,697,967, which claims priority to U.S. Provisional Application No. 60/754,870 filed Dec. 28, 2005, the disclosures of each of which are incorporated herein by reference for all purposes. The present application is also a continuation-in-part of U.S. patent application Ser. No. 12/032,593 filed Feb. 15, 2008, now U.S. Pat. No. 9,636,450, which claims priority to U.S. Provisional Application No. 60/890,497 filed Feb. 19, 2007, the disclosures of each of which are incorporated herein by reference for all purposes.
- The present disclosure relates to a sensor delivery unit. More particularly, the present disclosure relates to a sensor inserter having a safety member to impede actuation of the inserter. The present disclosure also relates to an introducer having a holding member configured to releasably retain a sensor, such as an analyte sensor. The introducer can further comprise a compressible member configured to tent the skin and puncture the skin to a reduced depth during insertion of a sensor. The present disclosure also relates to a method of arming the sensor delivery unit.
- Diabetes Mellitus is an incurable chronic disease in which the body does not produce or properly utilize insulin. Insulin is a hormone produced by the pancreas that regulates blood sugar (glucose). In particular, when blood sugar levels rise, e.g., after a meal, insulin lowers the blood sugar levels by facilitating blood glucose to move from the blood into the body cells. Thus, when the pancreas does not produce sufficient insulin (a condition known as Type I Diabetes) or does not properly utilize insulin (a condition known as Type II Diabetes), the blood glucose remains in the blood resulting in hyperglycemia or abnormally high blood sugar levels.
- The vast and uncontrolled fluctuations in blood glucose levels in people suffering from diabetes cause long-term, serious complications. Some of these complications include blindness, kidney failure, and nerve damage. Additionally, it is known that diabetes is a factor in accelerating cardiovascular diseases such as atherosclerosis (hardening of the arteries), leading to stroke, coronary heart disease, and other diseases. Accordingly, one important and universal strategy in managing diabetes is to control blood glucose levels.
- The first step in managing blood glucose levels is testing and monitoring blood glucose levels by using conventional techniques, such as drawing blood samples, applying the blood to a test strip, and determining the blood glucose level using colorimetric, electrochemical, or photometric test meters. Another more recent technique for monitoring glucose levels is by using commercially available continuous glucose monitoring systems.
- In accordance with the monitoring of glucose levels, a sensor is typically subcutaneously or transcutaneously positioned under the skin of a user. In this regard, a sensor inserter assembly, which can be preloaded with a sensor, is employed to insert the sensor through the skin of a user. A new sensor is generally implanted under the user's skin every three to seven days. Thus, easy to use sensor inserter assemblies causing reduced trauma to the skin during use are desired.
- In certain embodiments, a sensor insertion assembly is provided that includes an inserter housing, an introducer including a body portion having a proximal end and a distal end and a shaft portion comprising a channel and a distal end, the shaft portion extending downwardly from an edge of the body portion, the shaft portion including a holding member disposed along a length of the channel, the holding member configured to substantially releasably retain a sensor, an on-body electronics unit, wherein the introducer is configured for insertion of the sensor through an aperture in the on-body electronics unit prior to insertion through skin and a drive mechanism included in the inserter housing and operatively coupled to the introducer that drives the introducer and retained sensor through the skin.
- In certain embodiments, the introducer holding member may include one or more rolling members disposed along a length of the shaft portion, the rolling members configured to contact and releasably retain the sensor. The introducer rolling members may be configured to rotate. The sensor retained by the shaft portion of the introducer may be displaced from the shaft portion upon rotation of the rolling members. The introducer rolling members may be disposed within the channel. The introducer rolling members may be disposed within a sidewall of the channel. The introducer shaft portion may include an aperture formed in the channel, and the sensor may include a flange extending from an edge of the sensor, the flange disposed in the aperture formed in the channel. The aperture may include a section configured to be wider than the width of a sensor flange such that the sensor may be displaced from the shaft. The introducer holding member may comprise a sponge material disposed along the channel of the shaft portion, the sponge material configured to provide a soft interference fit with a sensor disposed in the shaft portion.
- In certain embodiments, the introducer shaft portion is substantially hollow. The introducer shaft portion may be configured to retain at least a portion of the sensor substantially subcutaneously when the shaft portion is removed from a skin layer. The introducer distal end may include a tapered end configured to pierce the skin layer and at least a portion of the sensor may be substantially retained within the shaft portion while the tapered end is piercing through the skin layer. The sensor may be substantially contemporaneously transcutaneously introduced through the skin layer when the tapered end of the shaft portion is transcutaneously introduced to the skin layer. In certain embodiments, the sensor includes an analyte sensor. The analyte sensor may be a glucose sensor. The introducer may be configured to position the analyte sensor in fluid contact with an analyte of a user.
- In certain embodiments, the introducer may include a compressible member having a distal end, the compressible member attached to a lateral side of the introducer shaft portion, wherein the distal end of the compressible member is distal to the distal end of the introducer shaft portion. The compressible member may be configured to retract to allow the sharp to penetrate skin of a user.
- A detailed description of various aspects, features, and embodiments of the subject matter described herein is provided with reference to the accompanying drawings, which are briefly described below. The drawings are illustrative and are not necessarily drawn to scale, with some components and features being exaggerated for clarity. The drawings illustrate various aspects and features of the present subject matter and may illustrate one or more embodiment(s) or example(s) of the present subject matter in whole or in part.
-
FIG. 1 is a perspective view showing a sensor inserter and adhesive mount constructed in accordance with the disclosed subject matter; -
FIG. 2 is a perspective view of the adhesive mount and sensor attached to the user's skin in accordance with the disclosed subject matter; -
FIG. 3 is a perspective view of the transmitter attached to the adhesive mount in accordance with the disclosed subject matter; -
FIG. 4 is an exploded perspective view of the embodiment ofFIG. 1 ; -
FIG. 5 is a cross-sectional view of the inserter ofFIG. 1 ; -
FIG. 6 is a schematic depiction of an introducer and sensor in accordance with the disclosed subject matter; -
FIG. 7 is a is a schematic depiction of a shaft portion of the introducer in accordance with the disclosed subject matter; -
FIG. 8 is a perspective view of a shaft portions having one or more holding member in accordance with the disclosed subject matter; -
FIG. 9 is a sectional view of the shaft portion ofFIG. 8 in accordance with the disclosed subject matter; -
FIG. 10 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter; -
FIG. 11 is a perspective view of the shaft portion ofFIG. 10 in accordance with the disclosed subject matter; -
FIG. 12 is a perspective view of a shaft portion having one or more holding members in accordance with the disclosed subject matter; -
FIG. 13 is a sectional view of a shaft portion having one or more holding members in accordance with the disclosed subject matter in a first configuration; -
FIG. 14 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration; -
FIG. 15 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration; -
FIG. 16 is a perspective view of the shaft portion ofFIG. 15 in accordance with the disclosed subject matter; -
FIG. 17 is a perspective view of the shaft portion ofFIG. 15 in accordance with the disclosed subject matter; -
FIGS. 18-20 are views of a shaft portion in accordance with the disclosed subject matter; -
FIG. 21 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration; -
FIG. 22 is a sectional view of a shaft portion having one or more holding member in accordance with the disclosed subject matter in a second configuration; -
FIG. 23 is a side view of a shaft portion comprising a compressible member in accordance with the disclosed subject matter in a second configuration; -
FIG. 24 is an enlarged side view of a shaft portion ofFIG. 23 in accordance with the disclosed subject matter in a second configuration; -
FIG. 25 is a partial side view of a shaft portion ofFIG. 23 in accordance with the disclosed subject matter in a second configuration; -
FIG. 26 is a sectional view of a shaft portion ofFIG. 23 in accordance with the disclosed subject matter in a second configuration; -
FIG. 27 is a side view of a shaft portion ofFIG. 23 in accordance with the disclosed subject matter in a second configuration; -
FIG. 28-30 are schematic depictions of the introducer ofFIGS. 23-27 depressing the skin and retracting to allow introducer sharp to pierce the skin in accordance with the disclosed subject matter; -
FIGS. 31-45 are perspective views of some embodiments of the safety member of the sensor inserter assembly in accordance with the disclosed subject matter; -
FIG. 46 is a cross-sectional view of an inserter having a pin disposed against the shuttle of the inserter in accordance with the disclosed subject matter; and -
FIGS. 47-49 illustrate a method of arming a sensor. - A detailed description of the disclosure is provided herein. It should be understood, in connection with the following description, that the subject matter is not limited to particular embodiments described, as the particular embodiments of the subject matter may of course vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the disclosed subject matter will be limited only by the appended claims.
- Where a range of values is provided, it is understood that each intervening value between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the disclosed subject matter. Every range stated is also intended to specifically disclose each and every “sub-rang” of the stated range. That is, each and every range smaller than the outside range specified by the outside upper and outside lower limits given for a range, whose upper and lower limits are within the range from said outside lower limit to said outside upper limit (unless the context clearly dictates otherwise), is also to be understood as encompassed within the disclosed subject matter, subject to any specifically excluded range or limit within the stated range. Where a range is stated by specifying one or both of an upper and lower limit, ranges excluding either or both of those stated limits, or including one or both of them, are also encompassed within the disclosed subject matter, regardless of whether or not words such as “from”, “to”, “through”, or “including” are or are not used in describing the range.
- Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosed subject matter belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present disclosed subject matter, this disclosure may specifically mention certain exemplary methods and materials.
- All publications mentioned in this disclosure are, unless otherwise specified, incorporated herein by reference in its entirety herein for all purposes, including without limitation to disclose and describe the methods and/or materials in connection with which the publications are cited.
- The publications discussed herein are provided solely for their disclosure prior to the filing date of the present application. Nothing herein is to be construed as an admission that the present disclosed subject matter is not entitled to antedate such publication by virtue of prior disclosure. Further, the dates of publication provided may be different from the actual publication dates, which may need to be independently confirmed.
- As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise.
- Nothing contained in the Abstract or the Summary should be understood as limiting the scope of the disclosure. The Abstract and the Summary are provided for bibliographic and convenience purposes and due to their formats and purposes should not be considered comprehensive.
- As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present disclosed subject matter. Any recited method can be carried out in the order of events recited, or in any other order which is logically possible. Reference to a singular item, includes the possibility that there are plural of the same item present. When two or more items (for example, elements or processes) are referenced by an alternative “or”, this indicates that either could be present separately or any combination of them could be present together except where the presence of one necessarily excludes the other or others.
- Various exemplary embodiments of the analyte monitoring system and methods of the present disclosure are described in further detail below. Although the present disclosure is described primarily with respect to a glucose monitoring system, each aspect of the present disclosure is not intended to be limited to the particular embodiment so described. Accordingly, it is to be understood that such description should not be construed to limit the scope of the present disclosure, and it is to be understood that the analyte monitoring system can be configured to monitor a variety of analytes, as described below. Further, section headers, where provided, are merely for the convenience of the reader and are not to be taken as limiting the scope of the present disclosure in any way, as it will be understood that certain elements and features of the present disclosure have more than one function and that aspects of the present disclosure and particular elements are described throughout the specification.
- The present disclosure is generally directed to an analyte monitoring system including an apparatus, such as an inserter, configured to insert various devices into the body of a subject, such as for example, an analyte sensor, an infusion set, or a lancing device.
- Certain classes of analyte monitoring systems are provided in small, lightweight, battery-powered and electronically-controlled systems. Such systems may be configured to detect signals indicative of in vivo analyte levels using an electrochemical sensor, and collect such signals, with or without processing the signal. In some embodiments, the portion of the system that performs this initial processing may be configured to provide the raw or initially processed data to another unit for further collection and/or processing. Such provision of data may be effected, for example, via a wired connection, such as an electrical, or via a wireless connection, such as an IR or RF connection.
- Certain analyte monitoring systems for in vivo measurement employ a sensor that measures analyte levels in interstitial fluids under the surface of the subject's skin. These may be inserted partially through the skin or positioned entirely under the skin. A sensor in such a system may operate as an electrochemical cell. Such a sensor may use any of a variety of electrode configurations, such as a three-electrode configuration (e.g., with “working”, “reference” and “counter” electrodes), driven by a controlled potential (potentiostat) analog circuit, a two-electrode system configuration (e.g., with only working and counter electrodes), which may be self-biasing and/or self-powered, and/or other configurations. In some embodiments, the sensor may be positioned within a blood vessel.
- In certain systems, the analyte sensor is in communication with a sensor control unit. As used in this disclosure, an on-body unit sometimes refers to such a combination of an analyte sensor with such a sensor control unit. The analyte monitoring system may include an on-body unit including a sensor and a monitor unit. Exemplary embodiments of combination analyte sensor and sensor control unit configurations are further disclosed in, among others, U.S. patent application Ser. Nos. 12/873,301 and 11/530,473, now U.S. Pat. No. 9,398,882, the disclosures of each of which are incorporated herein by reference for all purposes. In some embodiments, the on-body unit includes electronics configured to process the signal generated by the sensor and may further include a transmitter, transceiver, or other communications electronics to provide the processed data to the monitor unit via a communication link between the on-body unit and the monitor unit.
- Analyte monitoring systems, in some embodiments, include an adhesive mounting unit for adhering the on-body unit to a patient's skin. Exemplary mounting units can be found in, among others, U.S. patent application Ser. Nos. 12/873,302, 13/171,401, now U.S. Pat. No. 9,572,534, and 11/027,230, now U.S. Pat. No. 8,571,624, the disclosures of each of which are incorporated herein by reference for all purposes. In certain embodiments, mounting units include a base module in addition to an adhesive. The base module may be configured to physically couple with the on-body unit electronics for adhesive mounting of the on-body unit electronics to the patient. Examples of such coupling embodiments can be found in, among others, Ser. No. 12/895,015, now U.S. Pat. No. 9,351,669, and Ser. No. 11/365,334, now U.S. Pat. No. 8,029,441, the disclosures of each of which are incorporated herein by reference for all purposes. In some embodiments the mounting unit may also include a temperature sensing module to monitor the temperature of the skin of the patient, such as disclosed in Ser. No. 11/026,766, the disclosure of which is incorporated herein by reference.
- In certain embodiments, the on-body unit is placed on the skin of the patient prior to insertion of the sensor through the skin. In such embodiments, the sensor may be inserted through an aperture in the on-body unit prior to penetration of skin. Exemplary disclosures of these embodiments can be found in, among others, U.S. Publication Nos. 2011/0213225, 2010/0198034, 2010/0324392, 2011/0319729, 2011/0288574, 2012/0010642 and 2013/0150691, the disclosures of which are incorporated herein by reference for all purposes.
- The monitor unit can include a display for displaying or communicating information to the user of the analyte monitoring system or the user's health care provider or another. The monitor unit is also referred to in this disclosure as a “receiver unit” or “receiver device”, or in some contexts, depending on the usage, as a “display unit,” “handheld unit,” or “meter”. In some embodiments, receiver may also include buttons and/or scroll wheel which allow a user to interact with a user interface located on receiver. The monitor unit, in some embodiments, may include, e.g., a mobile telephone device, a personal digital assistant, other consumer electronic device such as MP3 device, camera, radio, etc., or other communication-enabled data processing device.
- The monitor unit may perform data processing and/or analysis, etc. on the received analyte data to generate information pertaining to the monitored analyte levels. The monitor unit may incorporate a display screen, which can be used, for example, to display measured analyte levels, and/or audio component such as a speaker to audibly provide information to a user, and/or a vibration device to provide tactile feedback to a user. It is also useful for a user of an analyte monitor to be able to see trend indications (including the magnitude and direction of any ongoing trend), and such data may be displayed as well, either numerically, or by a visual indicator, such as an arrow that may vary in visual attributes, such as size, shape, color, animation, or direction. The receiver device may further incorporate an in vitro analyte test strip port and related electronics in order to be able to make discrete (e.g., blood glucose) measurements.
- In certain embodiments described herein, on-body unit and monitor unit communicate via communications link (in this embodiment, a wireless RF connection). Communication may occur, e.g., via RF communication, infrared communication, Bluetooth® communication, Zigbee® communication, 802.1x communication, or WiFi communication, etc. In some embodiments, the communication may include an RF frequency of 433 MHz, 13.56 MHz, or the like. In some embodiments, a secondary monitor unit may be provided. A data processing terminal may be provided for providing further processing or review of analyte data.
- In certain embodiments, the analyte monitoring system may be a continuous analyte monitor (e.g., a continuous glucose monitoring system or CGM), and accordingly operate in a mode in which the communications via communications link has sufficient range to support a flow of data from the on-body unit to the monitor unit. In some embodiments, the data flow in a CGM system is automatically provided by the on-body unit to the monitor unit. For example, in some embodiments no user intervention is required for the on-body unit to send the data to the monitor unit. In some embodiments, the on-body unit provides the signal relating to analyte level to the receiving unit 300 on a periodic basis. For example, the signal may be provided, e.g., automatically sent, on a fixed schedule, e.g., once every 250 ms, once a second, once a minute, etc. In some embodiments, the signal is provided to the monitor unit upon the occurrence of an event, e.g., a hyperglycemic event or a hypoglycemic event, etc. In some embodiments, on-body unit may further include local memory in which it may record “logged data” or buffered data collected over a period of time and provide the some or all of the accumulated data to monitor unit from time-to-time. A separate data logging unit may be provided to acquire periodically received data from on-body unit. Data transmission may be one-way communication, e.g., the on-body unit provides data to the monitor unit without receiving signals from the monitor unit. In some embodiments, two-way communication is provided between the on-body unit and the monitor unit.
- In some embodiments, the analyte monitoring system includes a sensor which obtains an analyte signal which is provided to the monitor unit “on demand.” According to such embodiments, the monitor unit requests a signal from the on-body unit, or the on-body unit may be activated to send signal upon activation to do so. Accordingly, one or both of the on-body unit and monitor unit may include a switch activatable by a user or activated upon some other action or event, the activation of which causes analyte-related signal to be transferred from the on-body unit to the monitor unit. For example, the monitor unit is placed in close proximity with a transmitter device and initiates a data transfer, either over a wired connection, or wirelessly by various means, including, for example various RF-carried encodings and protocols and IR links.
- In some embodiments, the signal relating to analyte level is instantaneously generated by the analyte sensor upon receipt of the request, and provided to the monitor unit as requested, and/or the signal relating to analyte level is periodically obtained, e.g., once every 250 ms, once a second, once a minute, etc. Upon receipt of the “on demand” request at the on-body unit, an analyte signal is provided to the monitor unit. In some cases, the signal provided to the monitor unit is or at least includes the most recent analyte signal(s).
- In further embodiments, additional data is provided to the monitor unit “on demand.” For example, analyte trend data may be provided. Such trend data may include two or more analyte data points to indicate that analyte levels are rising, falling, or stable. Analyte trend data may include data from longer periods of time, such as, e.g., several minutes, several hours, several days, or several weeks.
- In some embodiments, analyte monitoring systems may further include medication infusion devices integrated therewith. Examples of such embodiments can be found in, among others, U.S. patent application Ser. No. 11/552,065, now U.S. Pat. No. 9,259,175, and Ser. No. 12/032,593, now U.S. Pat. No. 9,636,450, the disclosures of each of which are incorporated herein by reference for all purposes.
- Further embodiments of analyte monitoring systems and on demand analyte monitoring system are further disclosed in U.S. Pat. No. 6,175,752 and U.S. Publication Nos. 2011/0213225, 2010/0198034, 2010/0324392, 2011/0319729, 2011/0288574, 2012/0010642 and 2013/0150691, the disclosures of each of which are incorporated herein by reference for all purposes. Further details regarding on demand systems are also disclosed in U.S. Pat. No. 7,620,438, U.S. Patent Publication Nos. 2009/0054749, 2007/0149873, 2008/0064937, 2008/0071157, 2008/0071158, 2009/0281406, 2008/0058625, 2009/0294277, 2008/0319295, 2008/0319296, 2009/0257911, 2008/0179187, 2007/0149875, 2009/0018425, and U.S. patent application Ser. No. 12/625,524, now U.S. Pat. No. 8,390,455, Ser. No. 12/625,525, now U.S. Pat. No. 8,358,210, Ser. No. 12/625,528, now U.S. Pat. No. 8,115,635, Ser. Nos. 12/628,201, 12/628,177, 12/628,198, 12/628,203, 12/628,210, 12/393,921, 61/149,639, 12/495,709, 61/155,889, 61/155,891, 61/155,893, 61/165,499, 61/227,967, 61/163,006, 12/495,730, 12/495,712, now U.S. Pat. No. 8,437,827, 61/238,461, 61/256,925, 61/238,494, 61/238,159, 61/238,483, 61/238,581, 61/247,508, 61/247,516, 61/247,514, 61/247,519, 61/249,535, Ser. Nos. 12/544,061, 12/625,185, now U.S. Pat. No. 8,354,013, Ser. No. 12/625,208, now U.S. Pat. No. 9,042,954, Ser. Nos. 12/624,767, 12/242,780, now U.S. Pat. No. 8,983,568, Ser. Nos. 12/183,602, 12/211,014, now U.S. Pat. No. 8,636,884, and Ser. No. 12/114,359, now U.S. Pat. No. 8,080,385, the disclosures of each of which are incorporated by reference in their entirety herein for all purposes.
- The sensor, in accordance with one embodiment of the present disclosure, can be configured to detect and monitor an analyte of interest present in a biological sample of a user. The biological sample can be a biological fluid containing the analyte of interest, such as (but not limited to) interstitial fluid, blood, and urine. The analyte of interest can be one or more analytes including acetyl choline, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase (e.g., CK-MB), creatine, DNA, fructosamine, glucose, glutamine, growth hormones, hormones, ketones, lactate, peroxide, prostate-specific antigen, prothrombin, RNA, thyroid stimulating hormone, and troponin. However, other suitable analytes can also be monitored, as would be known in the art. Furthermore, the analyte monitoring system can be configured to monitor the concentration of drugs, such as, for example, antibiotics (e.g., gentamicin, vancomycin, and the like), digitoxin, digoxin, theophylline, warfarin, and the like.
- During use, the sensor is physically positioned in or on the body of a user whose analyte level is being monitored by an insertion device. The sensor can be configured to continuously sample the analyte level of the user and convert the sampled analyte level into a corresponding data signal for transmission by the transmitter. In some embodiments, the sensor is implantable into a subject's body for a period of time (e.g., three days, five days, seven days, etc.) to contact and monitor an analyte present in the biological fluid. Thus, a new sensor must be used typically every three to seven days.
- Generally, the sensor comprises a substrate, one or more electrodes, a sensing layer and a barrier layer, as described below and disclosed in U.S. Pat. Nos. 6,284,478 and 6,990,366, the disclosures of which are incorporated by reference in their entirety herein for all purposes. In one embodiment, the sensor includes a substrate. In some embodiments, the substrate is formed from a relatively flexible material. Suitable materials for a flexible substrate include, for example, non-conducting plastic or polymeric materials and other non-conducting, flexible, deformable materials. Suitable plastic or polymeric materials include thermoplastics such as polycarbonates, polyesters (e.g., Mylar® and polyethylene terephthalate (PET)), polyvinyl chloride (PVC), polyurethanes, polyethers, polyamides, polyimides, or copolymers of these thermoplastics, such as PETG (glycol-modified polyethylene terephthalate). In other embodiments, the sensor includes a relatively rigid substrate. Suitable examples of rigid materials that may be used to form the substrate include poorly conducting ceramics, such as aluminum oxide and silicon dioxide. Further, the substrate can be formed from an insulating material. Suitable insulating materials include polyurethane, Teflon (fluorinated polymers), polyethyleneterephthalate (PET, Dacron) or polyimide.
- The substrate can include a distal end and a proximal end. In some embodiments, the distal and proximal ends have different widths. In some embodiments, the distal and proximal ends have the same width. In some embodiments, the proximal end of the sensor remains above the skin surface. In such embodiments, the distal end of the substrate may have a relatively narrow width. Moreover, sensors intended to be positioned at least partially into the tissue of a user's body at can be configured to have narrow distal end or distal point to facilitate the insertion of the sensor. For example, for insertable sensors designed for continuous or periodic monitoring of the analyte during normal activities of the patient, a distal end of the sensor which is to be implanted into the user has a width of 2 mm or less, preferably 1 mm or less, and more preferably 0.5 mm or less. In certain embodiments, as disclosed in U.S. patent application Ser. No. 12/870,818, the disclosure of which is incorporated herein by reference, the sensor substrate distal end is constructed of material and shape to facilitate insertion of the distal end of the sensor through the skin of a patient without the use of an introducer sharp.
- A plurality of electrodes can be disposed near the distal end of sensor. The electrodes include working electrode, counter electrode and reference electrode. Other embodiments, however, can include a greater or fewer number of electrodes.
- Each of the electrodes is formed from conductive material, for example, a non-corroding metal or carbon wire. Suitable conductive materials include, for example, vitreous carbon, graphite, silver, silver-chloride, platinum, palladium, or gold. The conductive material can be applied to the substrate by various techniques including laser ablation, printing, etching, silk-screening, and photolithography. In one embodiment, each of the electrodes is formed from gold by a laser ablation technique. The sensor can include conductive traces extending from electrodes to corresponding, respective contacts to define the sensor electronic circuitry. In one embodiment, an insulating substrate (e.g., dielectric material) and electrodes are arranged in a stacked orientation (i.e., insulating substrate disposed between electrodes). Alternatively, the electrodes can be arranged in a side by side orientation (not shown), as described in U.S. Pat. No. 6,175,752, the disclosure of which is incorporated by reference in its entirety herein for all purposes.
- The sensor can include a sensing material having one or more components designed to facilitate the electrolysis of the analyte of interest. The components, for example, may be immobilized on the working electrode. Alternatively, the components of the sensing layer may be immobilized within or between one or more membranes or films disposed over the working electrode or the components may be immobilized in a polymeric or sol-gel matrix. Further aspects of the sensor are described in U.S. Pat. Nos. 5,262,035, 5,264,104, 5,264,105, 5,320,725, 5,593,852, and 5,665,222, each of which is incorporated by reference in its entirety herein for all purposes.
- In some embodiments, the sensor is a self-powered analyte sensor, which is capable of spontaneously passing a currently directly proportional to analyte concentration in the absence of an external power source. Any exemplary sensor is described in U.S. patent application Ser. No. 12/393,921, filed Feb. 26, 2009, which is hereby incorporated by reference in its entirety herein for all purposes.
- In one aspect of the present disclosure, an inserter is provided. The object to be inserted into the subject can be, for example, an analyte sensor as described above. Alternatively, other objects such as but not limited to an infusion set, or lancing device can be inserted.
- An exemplary embodiment of the
sensor inserter assembly 100 is illustrated inFIGS. 1-5 . Generally, thesensor inserter assembly 100 includes a sensor (not shown) preloaded withininserter 110. After preparing an insertion site on the skin of a user, the user removes anupper liner 116 andlower liner 118 from anadhesive mount 112 to expose the bottom surface and a portion of the top surface of an adhesive tape located on the bottom surface of themount 112.Mount 112, withinserter 110 attached, is then applied to the user's skin at the insertion site. The inserter includes anactuator button 124 to be pressed causinginserter 110 to fire, thereby inserting sensor 114 (not shown inFIG. 1 ) into the user's skin S. In some embodiments of the present disclosure, theinserter 110 includes a safety member to impede actuation of the inserter as described below.Mount 112, in certain embodiments, may be configured to receiveinserter 110 in only a single configuration, thus ensuring proper alignment of theinserter 110 on the mount. Exemplary embodiments of mount and inserter configured for proper alignment can be found in, among others, U.S. patent application Ser. Nos. 11/380,883, and 11/535,983, now U.S. Pat. No. 7,697,967, the disclosures of each of which are incorporated herein by reference for all purposes. - Once
sensor 114 has been inserted into the skin S, the user removesinserter 110 frommount 112 by pressingrelease tabs 126 on opposite sides ofinserter 110 and liftinginserter 110 away frommount 112. Further details of theinserter assembly 100 are provided in U.S. Pat. No. 7,381,184, which is incorporated by reference in its entirety herein for all purposes. In other embodiments, the inserter maybe integrated with the mount, wherein after insertion of the sensor through the skin of the patient, the sensor electronics unit is slid into place on the mount, while the inserter remains part of the mount. Exemplary embodiments are disclosed in, among others, U.S. patent application Ser. No. 11/216,932, now U.S. Pat. No. 7,731,657, Ser. Nos. 11/192,773, 11/240,257, now U.S. Pat. No. 7,883,464, Ser. No. 11/240,259, now U.S. Pat. No. 8,512,243, and Ser. No. 11/530,472, now U.S. Pat. No. 8,333,714, the disclosures of each of which are incorporated herein by reference for all purposes. - Once
inserter 110 is removed frommount 112,sensor electronics unit 130 can be slid into place, as illustrated inFIG. 3 . The circuitry ofsensor electronics unit 130 makes electrical contact with the contacts onsensor 114 aftersensor electronics unit 130 is fully seated onmount 112. As discussed hereinabove,mount 112, together withsensor 114, andsensor electronics unit 130 comprises an on-body unit. In some embodiments,sensor electronics unit 130 may include communications circuitry, such as a transmitter, transceiver, or the like, for communicating with additional equipment. For example, once initialization and synchronization procedures are completed, electrochemical measurements fromsensor 114 can be sent, e.g., wirelessly fromsensor electronics unit 130 to a monitor unit, such asportable receiver 132, as shown inFIG. 3 .Sensor 114,mount 112 andsensor electronics unit 130 remain in place on the user for a predetermined period, currently envisioned to be several hours, to several days, e.g., about three days, about five days, about seven days, etc. After expiration of the lifetime of the sensor, these components are then removed so thatsensor 114 and mount 112 can be properly discarded. The entire procedure above can then be repeated with anew inserter 110,sensor 114 andmount 112. In some embodiments, thesensor electronics unit 130 andreceiver 132 are durable and are reused. - Referring to
FIG. 4 , theinserter assembly 100 according to one embodiment can be assembled as shown from the following components: e.g.,housing 134,actuator button 124,drive spring 136,shuttle 138, introducer sharp 140,sensor 114,retraction spring 142,inserter base 144,upper liner 116, mountingunit 112,adhesive tape 120, andlower liner 118. -
Sensor 114 has amain surface 146 slidably mounted betweenU-shaped rails 148 of introducer sharp 140. Introducer sharp 140 can be mounted to face 154 ofshuttle 138, such as with adhesive, heat stake or ultrasonic weld. U.S. patent application Ser. No. 11/216,932, now U.S. Pat. No. 7,731,657, Ser. No. 11/617,698, now U.S. Pat. No. 8,545,403, and Ser. No. 11/535,983, now U.S. Pat. No. 7,697,967, disclose additional embodiments of sensor introducer sharps and insertion devices, the disclosures of which is incorporated herein by reference. - In some embodiments,
shuttle 138 can be slidably and non-rotatably constrained onbase 144 byarcuate guides 160. The shuttle can be generally formed by anouter ring 162 and an inner cup-shapedpost 164 connected by twobridges 166.Bridges 166 can be configured to slide between the twoslots 168 formed betweenguides 160 and allowshuttle 138 to travel alongguides 160 without rotating.Retraction spring 142 can be captivated at its outer circumference byguides 160, at its bottom by the floor 170 (FIG. 5 ) ofbase 144, at its top bybridges 166, and at its inner circumference by the outer surface ofshuttle post 164.Drive spring 136 is captivated at its bottom and outer circumference by the inside surface ofshuttle post 164, at its top by the ceiling 172 (FIG. 5 ) insideactuator button 124, and at its inner circumference bystem 174 depending fromceiling 172. - When
drive spring 136 is compressed betweenactuator button 124 andshuttle 138 it can urgeshuttle 138 towardsbase 144. Whenretraction spring 142 is compressed betweenshuttle 138 andbase 144, it urgesshuttle 138 towardsactuator button 124. - In some embodiments, the
actuator button 124 is slidably received withinhousing 134 from below and resides in opening 176 at the top ofhousing 134 with limited longitudinal movement.Arms 178 on each side ofactuator button 124 can be configured to travel inchannels 180 along the inside walls ofhousing 134, as best seen inFIG. 5 . Longitudinal movement ofactuator button 124 can be limited in one direction by thebase 182 ofarms 178 contacting the edge of opening 176 at the top ofhousing 134, and in the other direction by the distal ends 184 ofarms 178 contactingstops 186 inchannels 180.Slots 188 are preferably provided in the top ofhousing 134 for ease of housing manufacture and so tools can be inserted to inwardly compressarms 178 beyondstops 186 to allowactuator button 124 to be removed fromhousing 134 if needed. - When
sensor 114,introducer 140,shuttle 138,retraction spring 142,drive spring 136 andactuator button 124 are assembled betweenbase 144 andhousing 134 as shown inFIG. 5 and described above,housing 134 is snapped into place onbase 144.Base 144 is held ontohousing 134 byupper base barbs 190 that engageupper openings 192 inhousing 134, andlower base barbs 194 that engagelower openings 192 inhousing 134. - Generally, in accordance with one embodiment of the present disclosure, as illustrated in
FIG. 6 , anintroducer 440 is provided which comprises abody portion 401 and ashaft portion 405.Introducer 440 is substantially identical tointroducer 140, and useful with an inserter, such asinserter assembly 100 described hereinabove, with the differences illustrated in the accompanying figures, and described herein. Theshaft portion 405 can include a substantially sharpdistal edge segment 403 to contact and pierce the skin of a user for transcutaneous placement of the sensor through the user's skin S. As shown, thesensor 114 is retained within theshaft portion 405 of theintroducer 440 and is configured to be held in position during insertion of the sensor through the user's skin by the substantially hollow cylindrical shape of theshaft portion 405, as illustrated inFIG. 6 . - In some embodiments, referring to
FIGS. 6 and 7 , the tip of theanalyte sensor 114 can be retained at thedistal edge segment 403 of theintroducer 440 during the subcutaneously or transcutaneous positioning of thesensor 114 through the user's skin. Thus, thesensor 114 is positioned within the substantiallyhollow shaft portion 405 of theintroducer 440. Thedistal edge segment 403 of theintroducer 440 is configured to first pierce through the user's skin, and guide sensor retained in theshaft portion 405 of theintroducer 440 through the pierced skin of the user. After placement of thesensor 114 at the desired location under the skin, theintroducer 440 can be retracted from the user, leaving thesensor 114 in place. In some embodiments, during the introducer removal process, aradial configuration 404 of theshaft portion 405 is configured to guide the removal of theintroducer 440 from the pierced skin. - In some embodiments, the shaft portion includes one or more holding members configured to retain the sensor in the introducer. For example, but not limitation, the
shaft portion 405 of theintroducer 440 may have a ribbed configuration to provide additional friction fit during the insertion of the introducer and sensor through the skin of the user. - The holding member can include various configurations, as depicted in
FIGS. 8 to 31 . In one embodiment, as shown inFIGS. 8-9 , theshaft portion 405 may include one or morerolling members 406. The rollingmembers 406 can include for example rollers, balls, or wheels. In some embodiments, the rollingmembers 406 are disposed within the channel or wall of theshaft portion 405. The rollingmembers 406 are configured to retain thesensor 114 in theintroducer 140 by friction forces prior to insertion of thesensor 114 into the user's body. During the insertion process, the rollingmembers 406 can turn or rotate to displace thesensor 114 from theintroducer shaft 405 during the insertion process. When thesensor 114 is placed at the desired depth and caught in the mount as part of the insertion (e.g., by hook, clamp or gripper), the rollingmembers 406 rotate from the friction from thesensor 114 as the introducer exits back into the inserter. - In some embodiments, as shown in
FIGS. 10-11 , theshaft portion 405 of theintroducer 140 and thesensor 114 comprise amagnet 408 or magnetizedarea 409, such that magnetic forces retain the sensor within the introducer. The magnetic material can be any material that will provide magnetic forces including, but not limited to, low grade stainless steel, carbon ink, and the like. In some embodiments, the shaft or the sensor can be doped with magnetic metal. The magnet can be disposed along the channel of the shaft portion. In this regard, in accordance with one embodiment, magnetic material can be embedded on the surface of the sensor. Further, a magnet or a magnetized area is fit into the sharp to hold the sensor in place. Release of the magnetic force can occur when theshaft portion 405 is removed as part of the insertion process of the sensor delivery unit. - In other embodiments, as illustrated in
FIG. 12 , the holding member comprises asheath 407 disposed coaxially about theshaft portion 405. Thesheath 407 can comprise one or more perforations along aperforation line 410 disposed along a length of the sheath. In this manner, the sheath can be a tear away member. In some embodiments, the sheath comprises a polymer film. The polymer film can be attached to an outer surface of the shaft portion. Suitable materials for the sheath include polyimide, Pebax, polyethylene, Nylon, PTFE, polyester, and polyurethane. - In another embodiment, as depicted in
FIGS. 13-14 , theshaft portion 405 can include one ormore windings 411 configured to releasably retain thesensor 114. The windings are generally awound member 411 having the capability to unwind, as illustrated inFIG. 14 . While the winding 411 is in the wound configuration, it applies an interference against the sensor body to retain thesensor 114. The sensor can be displaced from theshaft portion 405 upon unwinding the one or more windings. In some embodiments, the windings comprise wound rolls of polymer film. - In other embodiments, the
shaft portion 405 of theintroducer 140 includes a substantiallylongitudinal opening 412, as shown inFIGS. 15-17 . Thesensor 114 can include aflange 413 disposed along an edge of thesensor body 114 to communicate through thelongitudinal opening 412. The engagement of thelongitudinal opening 412 and theflange 413 provide an interference fit to retain thesensor 114. In some embodiments, the slot includes adistal section 412B configured to be wider than the width of aproximal section 412A, and sufficiently wide such that thesensor flange 413 may be displaced from the shaft when the flange becomes disposed in the wider section of theopening 412, for example during the insertion process as the sensor travels towards an insertion position. In this manner, thelongitudinal opening 412 can be provided with a greater width at a distal section to allow theintroducer 140 to be completely de-coupled from thesensor 114 retained within theshaft portion 405 during the placement thereof, so that theintroducer 140 may be removed completely from the user, while leaving in place thesensor 114. - As an alternative, illustrated in
FIGS. 18-20 thesensor 114 can be configured to include apin 415 extending from a lateral end of the sensor body. Similar to the flange member described above, the pin can engage aslot 412′ formed in the introducer so as to retain the sensor in the introducer. In some embodiments, the pin can be configured as ahinge member 416. - In yet another embodiment, the holding member can include a
sponge material 417 disposed along the channel of theshaft portion 405, as shown inFIG. 21 . Thesponge material 417 can be configured to provide a soft interference fit with asensor 114 disposed in theshaft portion 405 and may comprise polyurethane, polyether, polystyrene, or isoprene foams. The foams can be attached via adhesive, or applied during the lubricious coating process (i.e., a silicone coating used to reduce friction and make insertion more smooth). - In other embodiments, the
shaft 405 is provided with adiaphragm 418, such as a thin, semi-rigid membrane housed along a portion of the channel. The diaphragm can include anopening 419 to receive and retain the sensor, as shown inFIG. 22 . Thediaphragm 418 may be molded or cast polymer (silicone, urethane or TPE) plug or insert with a series of slits or webbing similar to an iris. Or it could be a type of a duckbill valve. In one embodiment, thediaphragm 418 is fixed (molded or glued) to the inner diameter of the introducer. Thediaphragm 418 may be rigid enough to hold the sensor but flexible to open when the senor is captured during insertion. - In another aspect of the present disclosure, the
introducer 440 may be configured to reduce the insertion and extraction forces through the user's skin, thus reducing trauma to the skin. In this regard, theintroducer 440 can be configured to include acompressible member 518 attached to a lateral side of theintroducer 440, as illustrated inFIGS. 23-24 . In some embodiments, thecompressible member 518 can include a first section, orbarrel 519, and a second section, orplunger 520, as shown inFIG. 23 . Thefirst section 519 can include a compressible body. For example, the compressible body can include a spring, such as a compression spring 522 (illustrated in dashed lines). In some embodiments, thefirst section 519 includes a housing comprising the spring. The springs may be helical compression springs having variable pitch and compression rate. The shape of the spring can be straight, hourglass, conical or barrel. Alternatively, a controlled friction can be used to allow aplunger 520 to move inside thebarrel 519 at a set force. When the predetermined “break force” is reached, theplunger 520 can move. As illustrated inFIGS. 26-27 , theshaft 405 of theintroducer 440 is attached in some embodiments to the housing of thecompression member 518. - In some embodiments, the
second section 520 of thecompressible member 518 is non-compressible, but retractable. For example, thesecond section 520 can be formed from a solid thermoplastic member. Thefirst section 519 can be configured to receive thesecond section 520. In this manner, thecompressible member 518 can be compressed upon retraction of thesecond section 520 within thefirst portion housing 519. In this regard, the first and second sections can have a telescoping relationship, such that the sliding engagement of the second member upwardly into the first member causes compression of the compressible member, as illustrated inFIG. 25 . A first position ofsecond section 520 is illustrated in dashed line and the second position of thesecond section 520 is illustrated in solid line. The compression of thecompressible member 518 by the retraction of thesecond member 520 causes thedistal edge 403 of the introducer shaft, i.e., the sharp, to contact and pierce through the skin of the user. - During operation, as shown in
FIGS. 28-30 , thecompressible member 518 contacts the skin S of a user. During this process, thesecond section 520 of the compressible member contacts the skin S prior to theintroducer edge 403 because the distal end of thecompressible member 518 is initially distal to the introducerdistal end 403. SeeFIGS. 28-29 . In this manner, thesecond member 520 can depress the skin S from the pressure of the contact between thesecond section 520 and the skin S. As shown inFIG. 30 , thedistal end 403 of theintroducer 440 then makes contact with the skin S, as thecompressible section 518 compressed upon retraction of thesecond section 520 upwardly to allow thedistal end 403 of theintroducer 440 to puncture the skin S and proceed to insert the sensor 114 (not shown inFIG. 30 ). Thecompressible member 518 allows control of the depth of the puncture. By maintaining a relatively small skin puncture, it is possible to reduce the amount of potential bleeding during the skin piercing process for subcutaneous or transcutaneous sensor placement, and likewise the result is less bruising and also faster healing. - In some embodiments, the
edge segment 403 of theintroducer 440 guides thesensor 114 into and through the skin puncture. Theedge segment 403 may be sharpened and polished to facilitate a smooth puncture and a clean cut through the user's skin. In this regard, the substantially hollow shaft portion can be configured to minimize the necessary force to deploy the introducer, and minimize pain and skin trauma during puncture and removal of the introducer from the skin. In this regard, theedge segment 403 of theintroducer 440 includes a substantially sharp and angled tip (as shown inFIG. 6 ) for piercing the user's skin. Theedge segment 403 of theintroducer 440 can be sharp and tapered to facilitate skin piercing while minimizing skin trauma. In this manner, it is possible to minimize the size of the skin wound at the piercing site where theintroducer 440 is placed through the skin, and thus, the user will likely experience a faster healing time. - Referring to
FIGS. 31-45 ,actuator 124 described hereinabove can be provided with a safety member, such assafety member actuator button 124 from being depressed. Accordingly, the safety member can avoid accidental firing ofinserter assembly 100. The safety member can take the form of various configurations. - For example, the
safety member 625 can comprise a pin or a plug member, such as, but not limited to, a “grenade” pin, or molded plug, as disclosed inFIGS. 31-36 . In this regard, as depicted inFIGS. 31-32 , theactuator 124 can include one or more apertures or slots (not shown) extending through theactuator 124 through which thesafety pin 628 is disposed. The safety member can further include apull tab 626 for ease of removal to deactivate the safety. As depicted inFIGS. 33-34 , theactuator 124 can include one or more apertures or slots (not shown) extending through theactuator 124 through which thesafety pin 628′ is disposed. The safety member can further include apull tab 626′ for ease of removal to deactivate the safety. - In yet another embodiment, the
safety member 625″ can include a body having afirst end 630 and asecond end 632 configured to form an L-shaped body, as shown inFIGS. 35-36 . In this regard, the L-shaped safety member includes, as part of its unitary body apull tab 630 that protrudes from the slot or aperture formed inactuator 124. In this manner, the first or second ends of the L-shaped body can define a pull tab for deactivation of the safety. - In other embodiments, the safety member comprises a D-
ring 634, as shown inFIGS. 37-38 . TheD ring 634 can be formed from plastic or a metal. As illustrated inFIG. 39 , the actuator can include a slot having an opening in communication with the exterior of the actuator. The D-ring can be slid and disposed in the slot, as shown inFIG. 38 . - In yet another embodiment, the safety member can comprise a
press clip 636, as illustrated inFIGS. 40-42 . Thepress clip 636, in some embodiments, comprises first andsecond legs member 642. Thepress clip 636 includes first andsecond feet FIGS. 41 and 42 . The configuration ofclip 636 provides an outward force, as indicated byarrows 40. Thepress clip 646 can be disposed in one or more apertures formed on an interior surface of theactuator 124 as illustrated inFIG. 42 . - In yet another embodiment, the safety member can comprise a
press clip 650, as illustrated inFIGS. 43-45 . Thepress clip 650, in some embodiments, comprises first andsecond legs member 656. Thepress clip 650 includes first andsecond feet actuator 124, as illustrated inFIGS. 44 and 45 . The configuration ofclip 650 provides an inward force, as indicated byarrows 43. Thepress clip 650 can be disposed in one or more apertures formed on an exterior surface of theactuator 124 as illustrated inFIG. 45 . - During disposition of the
safety member 625 in the actuator, depression of the actuator is impeded. The safety member can be formed from a variety of materials. For example, the material can be a thermoplastic material, such as TPE materials or a metal. In some embodiments, the thermoplastic material has a shore hardness of about 40 to 50. In another embodiment, plastic, metal, wood, or paper can be formed in the shape of a pin as long as it could serve to prevent the downward movement of the button. - Upon deactivation of the safety member such as by removal of the safety member,
tabs 122, as illustrated inFIGS. 1 and 5 , can be squeezed inward just enough to clear therim 204 of opening 176 while pressing theactuator button 124 down to fire the inserter. Alternatively,tabs 122 can be squeezed further inward so that barbs on the inside edges can engage catches located on a center portion ofactuator button 124 by simply pressing down on theactuator button 124. - Referring back to
FIG. 5 ,shuttle 138 is provided with laterally extendingbarbed fingers 212 which travel inchannels 180 along the inside walls ofhousing 134. Whenshuttle 138 is inserted up intohousing 134 far enough,barbed fingers 212 momentarily deflect inward and then snap outward again to catch on stops 186. In this armed or cocked position as shown,drive spring 136 is compressed and urgingshuttle 138 towardsbase 144, butbarbed fingers 212 catching onstops 186 prevent such travel. - After manufacture of the sensor inserter assembly, the sensor inserter assembly can be shipped in an unarmed position. In this manner, no safety member as described above is necessary for safe shipping or handling as the sensor inserter assembly in its unarmed position cannot fire. In this regard, as shown in
FIG. 46 thesensor inserter assembly 110 in its unarmed position can include apin 728 member, such as a plastic tubular member, disposed in the firing path of the inserter. Thepin 728 is configured to butt against the bottom of theshuttle 138 and protrude from the bottom surface of the sensor inserter assembly, as shown inFIGS. 46 and 47 . Thepin 728 can keep the shuttle from bouncing on the return spring. - In another aspect of the present disclosure, a method is provided to arm the sensor inserter assembly. The sensor can be armed by the user prior to insertion of a sensor. The method includes, as shown in
FIGS. 47-49 , contacting the sensor inserter assembly against a surface, such as a table top. The contact of thepin 728 with a relatively hard surface causes the pin to be pushed upwardly the retraction position such that thebarbed fingers 212 are moved to a cocked position, as described above. In this manner, the sensor inserter assembly can be configured such that an audible click is sounded when the barbed fingers move to position. During movement to the armed position, theactuator button 124 moves upwardly to the cocked position. After the barbed fingers and the actuator are armed, thepin 728 is removed from the sensor insertion assembly and the sensor inserter assembly is armed and ready to use. - In operation, the user arms the drive mechanism, such as the first spring, to generate the sufficient inertial force needed to drive the introducer and the sensor through the user's skin. In one embodiment, the introducer and the sensor are provided in a fully assembled sensor inserter assembly package within a transmitter mounting unit. Thus, when the user wishes to place the sensor subcutaneously or transcutaneously, the drive mechanism is armed, and the user places the transmitter mount on the surface of the user's skin where the user wishes to place the sensor. In other embodiments, the sensor insertion assembly may be self-arming, allowing for ease of insertion of the sensor. Examples of such embodiments can be found in, among others, U.S. patent application Ser. No. 12/129,573, now U.S. Pat. No. 8,613,703, the disclosure of which is incorporated herein by reference for all purposes.
- Additional embodiments of analyte sensor insertion devices can be found in, among others, U.S. patent application Ser. No. 11/552,072, now U.S. Pat. No. 9,788,771, Ser. No. 13/434,804, now U.S. Pat. No. 9,743,862, Ser. No. 11/216,932, now U.S. Pat. No. 7,731,657, Ser. No. 11/617,698, now U.S. Pat. No. 8,545,403, Ser. Nos. 11/380,883, and 11/535,983, now U.S. Pat. No. 7,697,967, the disclosures of which are incorporated herein by reference for all purposes. Such embodiments include insertion devices utilizing variable speed insertion, by varying the speed of the shuttle through the insertion device; shape memory alloy insertion devices, wherein the introducer is constructed of a shape memory alloy that changes shape from a compressed state to a rigid insertion shape upon activation of the shape memory alloy; and coupleable insertion devices and on-skin mounting units, wherein the systems are configured such that the insertion device and on-skin mounting unit can only be coupled in a position such that the insertion device is aligned for proper sensor insertion.
- Various other modifications and alterations in the structure and method of operation of this present disclosure will be apparent to those skilled in the art without departing from the scope and spirit of the present disclosure. Although the present disclosure has been described in connection with specific embodiments, it should be understood that the present disclosure as claimed should not be unduly limited to such specific embodiments. It is intended that the following claims define the scope of the present disclosure and that structures and methods within the scope of these claims. Additional detailed description of embodiments of the disclosed subject matter are provided in but not limited to: U.S. Pat. Nos. 7,299,082; 7,167,818; 7,041,468; 6,942,518; 6,893,545; 6,881,551; 6,773,671; 6,764,581; 6,749,740; 6,746,582; 6,736,957; 6,730,200; 6,676,816; 6,618,934; 6,616,819; 6,600,997; 6,592,745; 6,591,125; 6,560,471; 6,540,891; 6,514,718; 6,514,460; 6,503,381; 6,461,496; 6,377,894; 6,338,790; 6,299,757; 6,284,478; 6,270,455; 6,175,752; 6,161,095; 6,144,837; 6,143,164; 6,121,009; 6,120,676; 6,071,391; 5,918,603; 5,899,855; 5,822,715; 5,820,551; 5,628,890; 5,601,435; 5,593,852; 5,509,410; 5,320,715; 5,264,014; 5,262,305; 5,262,035; 4,711,245; 4,545,382; 5,356,786; 5,543,326; 6,103,033; 6,134,461; 6,143,164; 6,144,837; 6,161,095; 6,579,690; 6,605,200; 6,605,201; 6,618,934; 6,654,625; 6,676,816; 6,730,200; 6,736,957; and 6,932,892; and U.S. Publication Nos. 2004/0186365; 2005/0182306; 2006/0025662; 2006/0091006; 2007/0056858; 2007/0068807; 2007/0095661; 2007/0108048; 2007/0199818; 2007/0227911; 2007/0233013; 2008/0066305; 2008/0081977; 2008/0102441; 2008/0148873; 2008/0161666; 2008/0267823; and 2009/0054748; and U.S. patent application Ser. No. 10/745,878, filed Dec. 26, 2003, now U.S. Pat. No. 7,811,231; U.S. patent application Ser. No. 12/143,731, filed Jun. 20, 2008, now U.S. Pat. No. 8,597,188; U.S. patent application Ser. No. 12/143,734, filed Jun. 20, 2008, now U.S. Pat. No. 8,617,069; U.S. Provisional Application No. 61/149,639, filed Feb. 3, 2009; U.S. Provisional Application No. 61/291,326 filed Dec. 30, 2009, and U.S. Provisional Application No. 61/299,924 filed Jan. 29, 2010; U.S. patent application Ser. No. 11/461,725, now U.S. Pat. No. 7,866,026; U.S. patent application Ser. No. 12/131,012; U.S. patent application Ser. No. 12/242,823, now U.S. Pat. No. 8,219,173; U.S. patent application Ser. No. 12/363,712, now U.S. Pat. No. 8,346,335; U.S. patent application Ser. No. 12/698,124; U.S. patent application Ser. No. 12/698,129, now U.S. Pat. No. 9,402,544; U.S. patent application Ser. No. 12/714,439; U.S. patent application Ser. No. 12/794,721, now U.S. Pat. No. 8,595,607; U.S. patent application Ser. No. 12/842,013, now U.S. Pat. No. 9,795,326; U.S. Provisional Application No. 61/238,646; U.S. Provisional Application No. 61/345,562; U.S. Provisional Application No. 61/361,374; and elsewhere, the disclosures of each are incorporated by reference in their entirety herein for all purposes.
- The foregoing only illustrates the principles of the disclosed subject matter. Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein. It will be appreciated that those skilled in the art will be able to devise numerous modifications which, although not explicitly described herein, embody the principles of the disclosed subject matter and are thus within the spirit and scope of the disclosed subject matter.
Claims (21)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/514,193 US20220125346A1 (en) | 2004-12-29 | 2021-10-29 | Sensor inserter having introducer |
Applications Claiming Priority (43)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/027,230 US8571624B2 (en) | 2004-12-29 | 2004-12-29 | Method and apparatus for mounting a data transmission device in a communication system |
US11/026,766 US20090082693A1 (en) | 2004-12-29 | 2004-12-29 | Method and apparatus for providing temperature sensor module in a data communication system |
US11/192,773 US20070027381A1 (en) | 2005-07-29 | 2005-07-29 | Inserter and methods of use |
US11/216,932 US7731657B2 (en) | 2005-08-30 | 2005-08-30 | Analyte sensor introducer and methods of use |
US11/240,259 US8512243B2 (en) | 2005-09-30 | 2005-09-30 | Integrated introducer and transmitter assembly and methods of use |
US11/240,257 US7883464B2 (en) | 2005-09-30 | 2005-09-30 | Integrated transmitter unit and sensor introducer mechanism and methods of use |
US75487005P | 2005-12-28 | 2005-12-28 | |
US11/365,334 US8029441B2 (en) | 2006-02-28 | 2006-02-28 | Analyte sensor transmitter unit configuration for a data monitoring and management system |
US11/380,883 US20090105569A1 (en) | 2006-04-28 | 2006-04-28 | Introducer Assembly and Methods of Use |
US11/530,472 US8333714B2 (en) | 2006-09-10 | 2006-09-10 | Method and system for providing an integrated analyte sensor insertion device and data processing unit |
US11/530,473 US9398882B2 (en) | 2005-09-30 | 2006-09-10 | Method and apparatus for providing analyte sensor and data processing device |
US11/535,983 US7697967B2 (en) | 2005-12-28 | 2006-09-28 | Method and apparatus for providing analyte sensor insertion |
US11/552,072 US9788771B2 (en) | 2006-10-23 | 2006-10-23 | Variable speed sensor insertion devices and methods of use |
US11/552,065 US9259175B2 (en) | 2006-10-23 | 2006-10-23 | Flexible patch for fluid delivery and monitoring body analytes |
US11/617,698 US8545403B2 (en) | 2005-12-28 | 2006-12-28 | Medical device insertion |
US89049707P | 2007-02-19 | 2007-02-19 | |
US94106007P | 2007-05-31 | 2007-05-31 | |
US12/032,593 US9636450B2 (en) | 2007-02-19 | 2008-02-15 | Pump system modular components for delivering medication and analyte sensing at seperate insertion sites |
US12/129,573 US8613703B2 (en) | 2007-05-31 | 2008-05-29 | Insertion devices and methods |
US23815909P | 2009-08-29 | 2009-08-29 | |
US23849409P | 2009-08-31 | 2009-08-31 | |
US23848309P | 2009-08-31 | 2009-08-31 | |
US23853709P | 2009-08-31 | 2009-08-31 | |
US24682509P | 2009-09-29 | 2009-09-29 | |
US24751609P | 2009-09-30 | 2009-09-30 | |
US12/571,349 US8852101B2 (en) | 2005-12-28 | 2009-09-30 | Method and apparatus for providing analyte sensor insertion |
US12/795,634 US8602991B2 (en) | 2005-08-30 | 2010-06-07 | Analyte sensor introducer and methods of use |
US35981610P | 2010-06-29 | 2010-06-29 | |
US12/870,818 US20110073475A1 (en) | 2009-08-29 | 2010-08-28 | Analyte Sensor |
US12/873,301 US20110054275A1 (en) | 2009-08-31 | 2010-08-31 | Mounting Unit Having a Sensor and Associated Circuitry |
US12/873,302 US20110060196A1 (en) | 2009-08-31 | 2010-08-31 | Flexible Mounting Unit and Cover for a Medical Device |
US12/893,974 US20110190603A1 (en) | 2009-09-29 | 2010-09-29 | Sensor Inserter Having Introducer |
US12/895,015 US9351669B2 (en) | 2009-09-30 | 2010-09-30 | Interconnect for on-body analyte monitoring device |
US13/022,616 US10194863B2 (en) | 2005-09-30 | 2011-02-07 | Integrated transmitter unit and sensor introducer mechanism and methods of use |
US201161470454P | 2011-03-31 | 2011-03-31 | |
US13/171,401 US9572534B2 (en) | 2010-06-29 | 2011-06-28 | Devices, systems and methods for on-skin or on-body mounting of medical devices |
US13/252,118 US9364149B2 (en) | 2006-02-28 | 2011-10-03 | Analyte sensor transmitter unit configuration for a data monitoring and management system |
US13/434,804 US9743862B2 (en) | 2011-03-31 | 2012-03-29 | Systems and methods for transcutaneously implanting medical devices |
US13/717,501 US8862198B2 (en) | 2006-09-10 | 2012-12-17 | Method and system for providing an integrated analyte sensor insertion device and data processing unit |
US13/970,397 US9480421B2 (en) | 2005-09-30 | 2013-08-19 | Integrated introducer and transmitter assembly and methods of use |
US14/040,674 US10226207B2 (en) | 2004-12-29 | 2013-09-28 | Sensor inserter having introducer |
US16/263,155 US11160475B2 (en) | 2004-12-29 | 2019-01-31 | Sensor inserter having introducer |
US17/514,193 US20220125346A1 (en) | 2004-12-29 | 2021-10-29 | Sensor inserter having introducer |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/263,155 Continuation US11160475B2 (en) | 2004-12-29 | 2019-01-31 | Sensor inserter having introducer |
Publications (1)
Publication Number | Publication Date |
---|---|
US20220125346A1 true US20220125346A1 (en) | 2022-04-28 |
Family
ID=49998896
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/040,674 Active 2028-06-19 US10226207B2 (en) | 2004-12-29 | 2013-09-28 | Sensor inserter having introducer |
US15/473,560 Abandoned US20170202488A1 (en) | 2004-12-29 | 2017-03-29 | Sensor Inserter Having Introducer |
US16/263,155 Active 2025-07-09 US11160475B2 (en) | 2004-12-29 | 2019-01-31 | Sensor inserter having introducer |
US17/514,193 Pending US20220125346A1 (en) | 2004-12-29 | 2021-10-29 | Sensor inserter having introducer |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/040,674 Active 2028-06-19 US10226207B2 (en) | 2004-12-29 | 2013-09-28 | Sensor inserter having introducer |
US15/473,560 Abandoned US20170202488A1 (en) | 2004-12-29 | 2017-03-29 | Sensor Inserter Having Introducer |
US16/263,155 Active 2025-07-09 US11160475B2 (en) | 2004-12-29 | 2019-01-31 | Sensor inserter having introducer |
Country Status (1)
Country | Link |
---|---|
US (4) | US10226207B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2623785A (en) * | 2022-10-26 | 2024-05-01 | Glucorx Tech Limited | Epidermal support patch |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8726266B2 (en) | 2010-05-24 | 2014-05-13 | Abbott Diabetes Care Inc. | Method and system for updating a medical device |
US20130267812A1 (en) | 2012-04-04 | 2013-10-10 | Dexcom, Inc. | Transcutaneous analyte sensors, applicators therefor, and associated methods |
EP2991552A4 (en) | 2013-04-30 | 2017-01-11 | Abbott Diabetes Care Inc. | Systems, devices, and methods for energy efficient electrical device activation |
US9610013B2 (en) * | 2013-11-14 | 2017-04-04 | Dexcom, Inc. | Indicator and analytics for sensor insertion in a continuous analyte monitoring system and related methods |
CN104739443B (en) * | 2013-12-30 | 2018-06-26 | 深圳迈瑞生物医疗电子股份有限公司 | A kind of medical external supersonic probe and diasonograph |
ES2911676T3 (en) | 2015-10-21 | 2022-05-20 | Dexcom Inc | Transcutaneous analyte sensors, applicators therefor, and associated methods |
ES2886024T3 (en) | 2016-02-05 | 2021-12-16 | Hoffmann La Roche | Medical device for detecting at least one analyte in a body fluid |
EP4241681B1 (en) | 2016-02-05 | 2024-10-02 | Roche Diabetes Care GmbH | Medical device for detecting at least one analyte in a body fluid |
JP7164548B2 (en) | 2017-05-09 | 2022-11-01 | アセンシア・ディアベティス・ケア・ホールディングス・アーゲー | Sensor assembly apparatus and method for continuous blood glucose monitoring |
WO2019122095A1 (en) * | 2017-12-21 | 2019-06-27 | Roche Diabetes Care Gmbh | Medical system and method of manufacturing thereof |
US11678846B2 (en) | 2019-08-02 | 2023-06-20 | Bionime Corporation | Insertion device for a biosensor |
US20210030319A1 (en) | 2019-08-02 | 2021-02-04 | Bionime Corporation | Physiological signal monitoring system for fast assembly |
US11896804B2 (en) | 2019-08-02 | 2024-02-13 | Bionime Corporation | Insertion device for a biosensor and insertion method thereof |
US11602373B2 (en) | 2019-08-20 | 2023-03-14 | Ascensia Diabetes Care Holdings Ag | Biosensor inserter apparatus and methods |
US11707297B2 (en) | 2019-08-20 | 2023-07-25 | Ascensia Diabetes Care Holdings Ag | Continuous analyte monitor inserter apparatus and methods |
CN110720930B (en) * | 2019-11-05 | 2023-06-27 | 微泰医疗器械(杭州)有限公司 | Needle aid and medical system comprising a needle aid |
JP2024504677A (en) | 2021-01-21 | 2024-02-01 | アセンシア・ダイアベティス・ケア・ホールディングス・アーゲー | Wearable continuous analyte measurement device, biosensor inserter, and method of use |
WO2022157290A1 (en) | 2021-01-21 | 2022-07-28 | Ascensia Diabetes Care Holdings Ag | Biosensor inserters and methods with reduced medical waste |
US20230397858A1 (en) * | 2022-06-10 | 2023-12-14 | Dexcom, Inc. | Apparatuses, systems, and methods of controlling sensor deployment |
Family Cites Families (868)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123790A (en) | 1964-03-03 | tyler | ||
US3211001A (en) | 1961-08-01 | 1965-10-12 | Barber Colman Co | Temperature sensing device |
US3260656A (en) | 1962-09-27 | 1966-07-12 | Corning Glass Works | Method and apparatus for electrolytically determining a species in a fluid |
GB1191363A (en) | 1968-02-19 | 1970-05-13 | Pavelle Ltd | Improvements in or relating to Electronic Thermostats. |
US3653841A (en) | 1969-12-19 | 1972-04-04 | Hoffmann La Roche | Methods and compositions for determining glucose in blood |
US3776832A (en) | 1970-11-10 | 1973-12-04 | Energetics Science | Electrochemical detection cell |
US3719564A (en) | 1971-05-10 | 1973-03-06 | Philip Morris Inc | Method of determining a reducible gas concentration and sensor therefor |
US3837339A (en) | 1972-02-03 | 1974-09-24 | Whittaker Corp | Blood glucose level monitoring-alarm system and method therefor |
US3949388A (en) | 1972-11-13 | 1976-04-06 | Monitron Industries, Inc. | Physiological sensor and transmitter |
US3908657A (en) | 1973-01-15 | 1975-09-30 | Univ Johns Hopkins | System for continuous withdrawal of blood |
US4100048A (en) | 1973-09-20 | 1978-07-11 | U.S. Philips Corporation | Polarographic cell |
US3926760A (en) | 1973-09-28 | 1975-12-16 | Du Pont | Process for electrophoretic deposition of polymer |
US3972320A (en) | 1974-08-12 | 1976-08-03 | Gabor Ujhelyi Kalman | Patient monitoring system |
US4245634A (en) | 1975-01-22 | 1981-01-20 | Hospital For Sick Children | Artificial beta cell |
US4036749A (en) | 1975-04-30 | 1977-07-19 | Anderson Donald R | Purification of saline water |
US3979274A (en) | 1975-09-24 | 1976-09-07 | The Yellow Springs Instrument Company, Inc. | Membrane for enzyme electrodes |
DE2645048A1 (en) | 1975-10-08 | 1977-04-21 | Gen Electric | PLANTABLE ELECTROCHEMICAL SENSOR |
US4016866A (en) | 1975-12-18 | 1977-04-12 | General Electric Company | Implantable electrochemical sensor |
US4055175A (en) | 1976-05-07 | 1977-10-25 | Miles Laboratories, Inc. | Blood glucose control apparatus |
DE2625834B2 (en) | 1976-06-09 | 1978-10-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Method for the determination of substrates or enzyme activities |
US4059406A (en) | 1976-07-12 | 1977-11-22 | E D T Supplies Limited | Electrochemical detector system |
US4076596A (en) | 1976-10-07 | 1978-02-28 | Leeds & Northrup Company | Apparatus for electrolytically determining a species in a fluid and method of use |
US4129128A (en) | 1977-02-23 | 1978-12-12 | Mcfarlane Richard H | Securing device for catheter placement assembly |
FR2387659A1 (en) | 1977-04-21 | 1978-11-17 | Armines | GLYCEMIA CONTROL AND REGULATION DEVICE |
US4098574A (en) | 1977-08-01 | 1978-07-04 | Eastman Kodak Company | Glucose detection system free from fluoride-ion interference |
US4178916A (en) | 1977-09-26 | 1979-12-18 | Mcnamara Elger W | Diabetic insulin alarm system |
JPS5912135B2 (en) | 1977-09-28 | 1984-03-21 | 松下電器産業株式会社 | enzyme electrode |
US4151845A (en) | 1977-11-25 | 1979-05-01 | Miles Laboratories, Inc. | Blood glucose control apparatus |
DK151000C (en) | 1978-02-17 | 1988-06-13 | Radiometer As | PROCEDURE AND APPARATUS FOR DETERMINING A PATIENT'S IN VIVO PLASMA-PH VALUE |
FR2420331A1 (en) | 1978-03-23 | 1979-10-19 | Claude Bernard | COMBINED MEASURING HEAD, INTENDED TO BE PLACED ON OR IN BODY PARTS, ALLOWING THE SIMULTANEOUS OBTAINING OF MEASUREMENT SIGNALS RELATING TO AN ELECTRICAL ACTIVITY ON THE ONE HAND AND AN IONIC ACTIVITY ON THE OTHER HAND |
US4172770A (en) | 1978-03-27 | 1979-10-30 | Technicon Instruments Corporation | Flow-through electrochemical system analytical method |
DE2817363C2 (en) | 1978-04-20 | 1984-01-26 | Siemens AG, 1000 Berlin und 8000 München | Method for determining the concentration of sugar and a suitable electrocatalytic sugar sensor |
US4344438A (en) | 1978-08-02 | 1982-08-17 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Optical sensor of plasma constituents |
HU177369B (en) | 1978-09-08 | 1981-09-28 | Radelkis Electrokemiai | Industrial molecule-selective sensing device and method for producing same |
US4240438A (en) | 1978-10-02 | 1980-12-23 | Wisconsin Alumni Research Foundation | Method for monitoring blood glucose levels and elements |
AU530979B2 (en) | 1978-12-07 | 1983-08-04 | Aus. Training Aids Pty. Ltd., | Detecting position of bullet fired at target |
US4247297A (en) | 1979-02-23 | 1981-01-27 | Miles Laboratories, Inc. | Test means and method for interference resistant determination of oxidizing substances |
US4573994A (en) | 1979-04-27 | 1986-03-04 | The Johns Hopkins University | Refillable medication infusion apparatus |
US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
US4365637A (en) | 1979-07-05 | 1982-12-28 | Dia-Med, Inc. | Perspiration indicating alarm for diabetics |
CS210174B1 (en) | 1979-07-12 | 1982-01-29 | Ivan Emmer | Method of making the electric hygrometric sensor |
US4458686A (en) | 1979-08-02 | 1984-07-10 | Children's Hospital Medical Center | Cutaneous methods of measuring body substances |
US4401122A (en) | 1979-08-02 | 1983-08-30 | Children's Hospital Medical Center | Cutaneous methods of measuring body substances |
US4450842A (en) | 1980-04-25 | 1984-05-29 | Cordis Corporation | Solid state reference electrode |
US4340458A (en) | 1980-06-02 | 1982-07-20 | Joslin Diabetes Center, Inc. | Glucose sensor |
US4356074A (en) | 1980-08-25 | 1982-10-26 | The Yellow Springs Instrument Company, Inc. | Substrate specific galactose oxidase enzyme electrodes |
US4404066A (en) | 1980-08-25 | 1983-09-13 | The Yellow Springs Instrument Company | Method for quantitatively determining a particular substrate catalyzed by a multisubstrate enzyme |
US4352960A (en) | 1980-09-30 | 1982-10-05 | Baptist Medical Center Of Oklahoma, Inc. | Magnetic transcutaneous mount for external device of an associated implant |
USRE32947E (en) | 1980-09-30 | 1989-06-13 | Baptist Medical Center Of Oklahoma, Inc. | Magnetic transcutaneous mount for external device of an associated implant |
US4425920A (en) | 1980-10-24 | 1984-01-17 | Purdue Research Foundation | Apparatus and method for measurement and control of blood pressure |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4390621A (en) | 1980-12-15 | 1983-06-28 | Miles Laboratories, Inc. | Method and device for detecting glucose concentration |
US4436094A (en) | 1981-03-09 | 1984-03-13 | Evreka, Inc. | Monitor for continuous in vivo measurement of glucose concentration |
AT369254B (en) | 1981-05-07 | 1982-12-27 | Otto Dipl Ing Dr Tech Prohaska | MEDICAL PROBE |
FR2508305B1 (en) | 1981-06-25 | 1986-04-11 | Slama Gerard | DEVICE FOR CAUSING A LITTLE BITE TO COLLECT A BLOOD DROP |
US4622966A (en) | 1981-06-30 | 1986-11-18 | Abbott Laboratories | Surgical cutting device |
US4440175A (en) | 1981-08-10 | 1984-04-03 | University Patents, Inc. | Membrane electrode for non-ionic species |
DE3138194A1 (en) | 1981-09-25 | 1983-04-14 | Basf Ag, 6700 Ludwigshafen | WATER-INSOLUBLE POROESES PROTEIN MATERIAL, THEIR PRODUCTION AND USE |
EP0078636B2 (en) | 1981-10-23 | 1997-04-02 | MediSense, Inc. | Sensor for components of a liquid mixture |
US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
US4418148A (en) | 1981-11-05 | 1983-11-29 | Miles Laboratories, Inc. | Multilayer enzyme electrode membrane |
US4494950A (en) | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
JPS58153154A (en) | 1982-03-09 | 1983-09-12 | Ajinomoto Co Inc | Qualified electrode |
US4581336A (en) | 1982-04-26 | 1986-04-08 | Uop Inc. | Surface-modified electrodes |
FI831399L (en) | 1982-04-29 | 1983-10-30 | Agripat Sa | KONTAKTLINS AV HAERDAD POLYVINYL ALCOHOL |
DE3221339A1 (en) | 1982-06-05 | 1983-12-08 | Basf Ag, 6700 Ludwigshafen | METHOD FOR THE ELECTROCHEMICAL HYDRATION OF NICOTINAMIDADENINE-DINUCLEOTIDE |
US4427770A (en) | 1982-06-14 | 1984-01-24 | Miles Laboratories, Inc. | High glucose-determining analytical element |
EP0098592A3 (en) | 1982-07-06 | 1985-08-21 | Fujisawa Pharmaceutical Co., Ltd. | Portable artificial pancreas |
US4509531A (en) | 1982-07-28 | 1985-04-09 | Teledyne Industries, Inc. | Personal physiological monitor |
DE3228551A1 (en) | 1982-07-30 | 1984-02-02 | Siemens AG, 1000 Berlin und 8000 München | METHOD FOR DETERMINING SUGAR CONCENTRATION |
US4534356A (en) | 1982-07-30 | 1985-08-13 | Diamond Shamrock Chemicals Company | Solid state transcutaneous blood gas sensors |
US4571292A (en) | 1982-08-12 | 1986-02-18 | Case Western Reserve University | Apparatus for electrochemical measurements |
US4552840A (en) | 1982-12-02 | 1985-11-12 | California And Hawaiian Sugar Company | Enzyme electrode and method for dextran analysis |
US4527240A (en) | 1982-12-29 | 1985-07-02 | Kvitash Vadim I | Balascopy method for detecting and rapidly evaluating multiple imbalances within multi-parametric systems |
US4461691A (en) | 1983-02-10 | 1984-07-24 | The United States Of America As Represented By The United States Department Of Energy | Organic conductive films for semiconductor electrodes |
US4679562A (en) | 1983-02-16 | 1987-07-14 | Cardiac Pacemakers, Inc. | Glucose sensor |
IT1170375B (en) | 1983-04-19 | 1987-06-03 | Giuseppe Bombardieri | Implantable device for measuring body fluid parameters |
US5509410A (en) | 1983-06-06 | 1996-04-23 | Medisense, Inc. | Strip electrode including screen printing of a single layer |
CA1226036A (en) | 1983-05-05 | 1987-08-25 | Irving J. Higgins | Analytical equipment and sensor electrodes therefor |
CA1219040A (en) | 1983-05-05 | 1987-03-10 | Elliot V. Plotkin | Measurement of enzyme-catalysed reactions |
CA1218704A (en) | 1983-05-05 | 1987-03-03 | Graham Davis | Assay systems using more than one enzyme |
US5682884A (en) | 1983-05-05 | 1997-11-04 | Medisense, Inc. | Strip electrode with screen printing |
US4484987A (en) | 1983-05-19 | 1984-11-27 | The Regents Of The University Of California | Method and membrane applicable to implantable sensor |
US4650547A (en) | 1983-05-19 | 1987-03-17 | The Regents Of The University Of California | Method and membrane applicable to implantable sensor |
US4524114A (en) | 1983-07-05 | 1985-06-18 | Allied Corporation | Bifunctional air electrode |
US4538616A (en) | 1983-07-25 | 1985-09-03 | Robert Rogoff | Blood sugar level sensing and monitoring transducer |
US4543955A (en) | 1983-08-01 | 1985-10-01 | Cordis Corporation | System for controlling body implantable action device |
US4655880A (en) | 1983-08-01 | 1987-04-07 | Case Western Reserve University | Apparatus and method for sensing species, substances and substrates using oxidase |
SE8305704D0 (en) | 1983-10-18 | 1983-10-18 | Leo Ab | Cuvette |
US4560534A (en) | 1983-11-02 | 1985-12-24 | Miles Laboratories, Inc. | Polymer catalyst transducers |
US4522690A (en) | 1983-12-01 | 1985-06-11 | Honeywell Inc. | Electrochemical sensing of carbon monoxide |
US6017335A (en) | 1983-12-12 | 2000-01-25 | Burnham; Warren R. | Method for making a tubular product, especially a catheter, and article made thereby |
EP0149339B1 (en) | 1983-12-16 | 1989-08-23 | MediSense, Inc. | Assay for nucleic acids |
EP0179823B1 (en) | 1984-04-30 | 1989-07-12 | Stiftung, R. E. | Process for the sensitization of an oxidoreduction photocalatyst, and photocatalyst thus obtained |
US5141868A (en) | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
DK8601218A (en) | 1984-07-18 | 1986-03-17 | ||
DE3429596A1 (en) | 1984-08-10 | 1986-02-20 | Siemens AG, 1000 Berlin und 8000 München | DEVICE FOR THE PHYSIOLOGICAL FREQUENCY CONTROL OF A PACEMAKER PROVIDED WITH A PICTURE ELECTRODE |
US4820399A (en) | 1984-08-31 | 1989-04-11 | Shimadzu Corporation | Enzyme electrodes |
CA1254091A (en) | 1984-09-28 | 1989-05-16 | Vladimir Feingold | Implantable medication infusion system |
JPS61111428A (en) | 1984-11-06 | 1986-05-29 | Terumo Corp | Electronic clinical thermometer |
US4627842A (en) | 1984-11-19 | 1986-12-09 | William Katz | Intravenous needle assembly |
US4717673A (en) | 1984-11-23 | 1988-01-05 | Massachusetts Institute Of Technology | Microelectrochemical devices |
US4721601A (en) | 1984-11-23 | 1988-01-26 | Massachusetts Institute Of Technology | Molecule-based microelectronic devices |
JPH0617889B2 (en) | 1984-11-27 | 1994-03-09 | 株式会社日立製作所 | Biochemical sensor |
EP0186210B1 (en) | 1984-12-28 | 1992-04-22 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Ion sensor |
GB8500729D0 (en) | 1985-01-11 | 1985-02-13 | Hill H A O | Surface-modified electrode |
DE3502913C1 (en) | 1985-01-29 | 1986-07-03 | Günter Prof. Dr.rer.nat. 5100 Aachen Rau | Sensor for non-invasive detection of electrophysiological values |
EP0200321A3 (en) | 1985-03-20 | 1987-03-11 | Ingeborg J. Hochmair | Transcutaneous signal transmission system |
US4627445A (en) | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US5279294A (en) | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
US4781798A (en) | 1985-04-19 | 1988-11-01 | The Regents Of The University Of California | Transparent multi-oxygen sensor array and method of using same |
US4671288A (en) | 1985-06-13 | 1987-06-09 | The Regents Of The University Of California | Electrochemical cell sensor for continuous short-term use in tissues and blood |
WO1986007632A1 (en) | 1985-06-21 | 1986-12-31 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method of manufacturing same |
US4938860A (en) | 1985-06-28 | 1990-07-03 | Miles Inc. | Electrode for electrochemical sensors |
US4796634A (en) | 1985-08-09 | 1989-01-10 | Lawrence Medical Systems, Inc. | Methods and apparatus for monitoring cardiac output |
US4805624A (en) | 1985-09-09 | 1989-02-21 | The Montefiore Hospital Association Of Western Pa | Low-potential electrochemical redox sensors |
US4680268A (en) | 1985-09-18 | 1987-07-14 | Children's Hospital Medical Center | Implantable gas-containing biosensor and method for measuring an analyte such as glucose |
US4890620A (en) | 1985-09-20 | 1990-01-02 | The Regents Of The University Of California | Two-dimensional diffusion glucose substrate sensing electrode |
US4627908A (en) | 1985-10-24 | 1986-12-09 | Chevron Research Company | Process for stabilizing lube base stocks derived from bright stock |
US4830959A (en) | 1985-11-11 | 1989-05-16 | Medisense, Inc. | Electrochemical enzymic assay procedures |
GB8529300D0 (en) | 1985-11-28 | 1986-01-02 | Ici Plc | Membrane |
US4755173A (en) | 1986-02-25 | 1988-07-05 | Pacesetter Infusion, Ltd. | Soft cannula subcutaneous injection set |
US4776944A (en) | 1986-03-20 | 1988-10-11 | Jiri Janata | Chemical selective sensors utilizing admittance modulated membranes |
US4685463A (en) | 1986-04-03 | 1987-08-11 | Williams R Bruce | Device for continuous in vivo measurement of blood glucose concentrations |
US4726378A (en) | 1986-04-11 | 1988-02-23 | Minnesota Mining And Manufacturing Company | Adjustable magnetic supercutaneous device and transcutaneous coupling apparatus |
US4757022A (en) | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4994167A (en) | 1986-04-15 | 1991-02-19 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4711247A (en) | 1986-04-18 | 1987-12-08 | Henry Fishman | Allergy testing method and apparatus |
US4909908A (en) | 1986-04-24 | 1990-03-20 | Pepi Ross | Electrochemical cncentration detector method |
DE3614821A1 (en) | 1986-05-02 | 1987-11-05 | Siemens Ag | IMPLANTABLE, CALIBRABLE MEASURING DEVICE FOR A BODY SUBSTANCE AND CALIBRATION METHOD |
US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
US4731726A (en) | 1986-05-19 | 1988-03-15 | Healthware Corporation | Patient-operated glucose monitor and diabetes management system |
GB8612861D0 (en) | 1986-05-27 | 1986-07-02 | Cambridge Life Sciences | Immobilised enzyme biosensors |
US4698057A (en) | 1986-06-09 | 1987-10-06 | Joishy Suresh K | Built in assembly for stabilizing and securing intravascular needle or catheter like device |
US4969468A (en) | 1986-06-17 | 1990-11-13 | Alfred E. Mann Foundation For Scientific Research | Electrode array for use in connection with a living body and method of manufacture |
CA1283447C (en) | 1986-06-20 | 1991-04-23 | John W. Parce | Zero volume electrochemical cell |
JPS636451A (en) | 1986-06-27 | 1988-01-12 | Terumo Corp | Enzyme sensor |
DE3721799C2 (en) | 1986-07-01 | 1993-12-23 | Mitsubishi Electric Corp | Integrated redox component circuit and method of manufacture |
US4917800A (en) | 1986-07-07 | 1990-04-17 | Bend Research, Inc. | Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers |
US4784736A (en) | 1986-07-07 | 1988-11-15 | Bend Research, Inc. | Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers |
US4726716A (en) | 1986-07-21 | 1988-02-23 | Mcguire Thomas V | Fastener for catheter |
US4894137A (en) | 1986-09-12 | 1990-01-16 | Omron Tateisi Electronics Co. | Enzyme electrode |
US5055171A (en) | 1986-10-06 | 1991-10-08 | T And G Corporation | Ionic semiconductor materials and applications thereof |
US4865038A (en) | 1986-10-09 | 1989-09-12 | Novametrix Medical Systems, Inc. | Sensor appliance for non-invasive monitoring |
US4897162A (en) | 1986-11-14 | 1990-01-30 | The Cleveland Clinic Foundation | Pulse voltammetry |
DE3700119A1 (en) | 1987-01-03 | 1988-07-14 | Inst Diabetestechnologie Gemei | IMPLANTABLE ELECTROCHEMICAL SENSOR |
US4934369A (en) | 1987-01-30 | 1990-06-19 | Minnesota Mining And Manufacturing Company | Intravascular blood parameter measurement system |
GB2201248B (en) | 1987-02-24 | 1991-04-17 | Ici Plc | Enzyme electrode sensors |
US4854322A (en) | 1987-02-25 | 1989-08-08 | Ash Medical Systems, Inc. | Capillary filtration and collection device for long-term monitoring of blood constituents |
US5002054A (en) | 1987-02-25 | 1991-03-26 | Ash Medical Systems, Inc. | Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body |
US4777953A (en) | 1987-02-25 | 1988-10-18 | Ash Medical Systems, Inc. | Capillary filtration and collection method for long-term monitoring of blood constituents |
US4848351A (en) | 1987-03-04 | 1989-07-18 | Sentry Medical Products, Inc. | Medical electrode assembly |
US4923586A (en) | 1987-03-31 | 1990-05-08 | Daikin Industries, Ltd. | Enzyme electrode unit |
US4935345A (en) | 1987-04-07 | 1990-06-19 | Arizona Board Of Regents | Implantable microelectronic biochemical sensor incorporating thin film thermopile |
US5352348A (en) | 1987-04-09 | 1994-10-04 | Nova Biomedical Corporation | Method of using enzyme electrode |
US4759828A (en) | 1987-04-09 | 1988-07-26 | Nova Biomedical Corporation | Glucose electrode and method of determining glucose |
US4749985A (en) | 1987-04-13 | 1988-06-07 | United States Of America As Represented By The United States Department Of Energy | Functional relationship-based alarm processing |
US4781683A (en) | 1987-04-22 | 1988-11-01 | The Johns Hopkins University | Single-use, self-annulling injection syringe |
EP0290683A3 (en) | 1987-05-01 | 1988-12-14 | Diva Medical Systems B.V. | Diabetes management system and apparatus |
US5286364A (en) | 1987-06-08 | 1994-02-15 | Rutgers University | Surface-modified electochemical biosensor |
US4822337A (en) | 1987-06-22 | 1989-04-18 | Stanley Newhouse | Insulin delivery method and apparatus |
JPH07122624B2 (en) | 1987-07-06 | 1995-12-25 | ダイキン工業株式会社 | Biosensor |
US4874500A (en) | 1987-07-15 | 1989-10-17 | Sri International | Microelectrochemical sensor and sensor array |
GB8718430D0 (en) | 1987-08-04 | 1987-09-09 | Ici Plc | Sensor |
JPS6423155A (en) | 1987-07-17 | 1989-01-25 | Daikin Ind Ltd | Electrode refreshing device for biosensor |
EP0378683B1 (en) | 1987-08-11 | 1995-11-02 | Terumo Kabushiki Kaisha | Automatic sphygmomanometer |
US4974929A (en) | 1987-09-22 | 1990-12-04 | Baxter International, Inc. | Fiber optical probe connector for physiologic measurement devices |
NL8702370A (en) | 1987-10-05 | 1989-05-01 | Groningen Science Park | METHOD AND SYSTEM FOR GLUCOSE DETERMINATION AND USEABLE MEASURING CELL ASSEMBLY. |
US4815469A (en) | 1987-10-08 | 1989-03-28 | Siemens-Pacesetter, Inc. | Implantable blood oxygen sensor and method of use |
GB8725936D0 (en) | 1987-11-05 | 1987-12-09 | Genetics Int Inc | Sensing system |
JPH01140054A (en) | 1987-11-26 | 1989-06-01 | Nec Corp | Glucose sensor |
US4813424A (en) | 1987-12-23 | 1989-03-21 | University Of New Mexico | Long-life membrane electrode for non-ionic species |
US5108564A (en) | 1988-03-15 | 1992-04-28 | Tall Oak Ventures | Method and apparatus for amperometric diagnostic analysis |
DE68924026T3 (en) | 1988-03-31 | 2008-01-10 | Matsushita Electric Industrial Co., Ltd., Kadoma | BIOSENSOR AND ITS MANUFACTURE. |
US4921199A (en) | 1988-04-25 | 1990-05-01 | Villaveces James W | Device for aiding in preparation of intravenous therapy |
GB8817421D0 (en) | 1988-07-21 | 1988-08-24 | Medisense Inc | Bioelectrochemical electrodes |
US4954129A (en) | 1988-07-25 | 1990-09-04 | Abbott Laboratories | Hydrodynamic clot flushing |
US4925268A (en) | 1988-07-25 | 1990-05-15 | Abbott Laboratories | Fiber-optic physiological probes |
EP0353328A1 (en) | 1988-08-03 | 1990-02-07 | Dräger Nederland B.V. | A polarographic-amperometric three-electrode sensor |
US5340722A (en) | 1988-08-24 | 1994-08-23 | Avl Medical Instruments Ag | Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method |
US5264106A (en) | 1988-10-07 | 1993-11-23 | Medisense, Inc. | Enhanced amperometric sensor |
US4995402A (en) | 1988-10-12 | 1991-02-26 | Thorne, Smith, Astill Technologies, Inc. | Medical droplet whole blood and like monitoring |
US4895147A (en) | 1988-10-28 | 1990-01-23 | Sherwood Medical Company | Lancet injector |
US5360404A (en) | 1988-12-14 | 1994-11-01 | Inviro Medical Devices Ltd. | Needle guard and needle assembly for syringe |
AT393213B (en) | 1989-02-08 | 1991-09-10 | Avl Verbrennungskraft Messtech | DEVICE FOR DETERMINING AT LEAST ONE MEDICAL MEASURING SIZE |
EP0384504A1 (en) | 1989-02-24 | 1990-08-29 | Duphar International Research B.V | Detection strip for detecting and identifying chemical air contaminants, and portable detection kit comprising said strips |
DE69027233T2 (en) | 1989-03-03 | 1996-10-10 | Edward W Stark | Signal processing method and apparatus |
US5205920A (en) | 1989-03-03 | 1993-04-27 | Noboru Oyama | Enzyme sensor and method of manufacturing the same |
US5089112A (en) | 1989-03-20 | 1992-02-18 | Associated Universities, Inc. | Electrochemical biosensor based on immobilized enzymes and redox polymers |
JPH02298855A (en) | 1989-03-20 | 1990-12-11 | Assoc Univ Inc | Electrochemical biosensor using immobilized enzyme and redox polymer |
US4953552A (en) | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
EP0396788A1 (en) | 1989-05-08 | 1990-11-14 | Dräger Nederland B.V. | Process and sensor for measuring the glucose content of glucosecontaining fluids |
US4988341A (en) | 1989-06-05 | 1991-01-29 | Eastman Kodak Company | Sterilizing dressing device and method for skin puncture |
US5198367A (en) | 1989-06-09 | 1993-03-30 | Masuo Aizawa | Homogeneous amperometric immunoassay |
FR2648353B1 (en) | 1989-06-16 | 1992-03-27 | Europhor Sa | MICRODIALYSIS PROBE |
CH677149A5 (en) | 1989-07-07 | 1991-04-15 | Disetronic Ag | |
US4986271A (en) | 1989-07-19 | 1991-01-22 | The University Of New Mexico | Vivo refillable glucose sensor |
US5431160A (en) | 1989-07-19 | 1995-07-11 | University Of New Mexico | Miniature implantable refillable glucose sensor and material therefor |
US5013161A (en) | 1989-07-28 | 1991-05-07 | Becton, Dickinson And Company | Electronic clinical thermometer |
US5264105A (en) | 1989-08-02 | 1993-11-23 | Gregg Brian A | Enzyme electrodes |
US5262035A (en) | 1989-08-02 | 1993-11-16 | E. Heller And Company | Enzyme electrodes |
US5264104A (en) | 1989-08-02 | 1993-11-23 | Gregg Brian A | Enzyme electrodes |
US5320725A (en) | 1989-08-02 | 1994-06-14 | E. Heller & Company | Electrode and method for the detection of hydrogen peroxide |
US4944299A (en) | 1989-08-08 | 1990-07-31 | Siemens-Pacesetter, Inc. | High speed digital telemetry system for implantable device |
US5101814A (en) | 1989-08-11 | 1992-04-07 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5190041A (en) | 1989-08-11 | 1993-03-02 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5095904A (en) | 1989-09-08 | 1992-03-17 | Cochlear Pty. Ltd. | Multi-peak speech procession |
US5050612A (en) | 1989-09-12 | 1991-09-24 | Matsumura Kenneth N | Device for computer-assisted monitoring of the body |
FR2652736A1 (en) | 1989-10-06 | 1991-04-12 | Neftel Frederic | IMPLANTABLE DEVICE FOR EVALUATING THE RATE OF GLUCOSE. |
EP0429076B1 (en) | 1989-11-24 | 1996-01-31 | Matsushita Electric Industrial Co., Ltd. | Preparation of biosensor |
US5036860A (en) | 1989-11-24 | 1991-08-06 | Medical Device Technologies, Inc. | Disposable soft tissue biopsy apparatus |
US5140985A (en) | 1989-12-11 | 1992-08-25 | Schroeder Jon M | Noninvasive blood glucose measuring device |
US5082550A (en) | 1989-12-11 | 1992-01-21 | The United States Of America As Represented By The Department Of Energy | Enzyme electrochemical sensor electrode and method of making it |
US5342789A (en) | 1989-12-14 | 1994-08-30 | Sensor Technologies, Inc. | Method and device for detecting and quantifying glucose in body fluids |
US5288636A (en) | 1989-12-15 | 1994-02-22 | Boehringer Mannheim Corporation | Enzyme electrode system |
US4985142A (en) * | 1989-12-15 | 1991-01-15 | Sundstrand Corporation | Quick release filter by-pass valve |
US5286362A (en) | 1990-02-03 | 1994-02-15 | Boehringer Mannheim Gmbh | Method and sensor electrode system for the electrochemical determination of an analyte or an oxidoreductase as well as the use of suitable compounds therefor |
US5109850A (en) | 1990-02-09 | 1992-05-05 | Massachusetts Institute Of Technology | Automatic blood monitoring for medication delivery method and apparatus |
US5161532A (en) | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
US5165407A (en) | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
US5202261A (en) | 1990-07-19 | 1993-04-13 | Miles Inc. | Conductive sensors and their use in diagnostic assays |
US5250439A (en) | 1990-07-19 | 1993-10-05 | Miles Inc. | Use of conductive sensors in diagnostic assays |
EP0550641B1 (en) | 1990-09-28 | 1994-05-25 | Pfizer Inc. | Dispensing device containing a hydrophobic medium |
US5058592A (en) | 1990-11-02 | 1991-10-22 | Whisler G Douglas | Adjustable mountable doppler ultrasound transducer device |
CA2098313C (en) | 1990-12-12 | 2001-06-19 | Gary J. O'hara | Infrared thermometer utilizing calibration mapping |
FR2673289B1 (en) | 1991-02-21 | 1994-06-17 | Asulab Sa | SENSOR FOR MEASURING THE QUANTITY OF A COMPONENT IN SOLUTION. |
CA2050057A1 (en) | 1991-03-04 | 1992-09-05 | Adam Heller | Interferant eliminating biosensors |
US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
US5262305A (en) | 1991-03-04 | 1993-11-16 | E. Heller & Company | Interferant eliminating biosensors |
US5469855A (en) | 1991-03-08 | 1995-11-28 | Exergen Corporation | Continuous temperature monitor |
US5238729A (en) | 1991-04-05 | 1993-08-24 | Minnesota Mining And Manufacturing Company | Sensors based on nanosstructured composite films |
US5208154A (en) | 1991-04-08 | 1993-05-04 | The United States Of America As Represented By The Department Of Energy | Reversibly immobilized biological materials in monolayer films on electrodes |
US5192416A (en) | 1991-04-09 | 1993-03-09 | New Mexico State University Technology Transfer Corporation | Method and apparatus for batch injection analysis |
US5293546A (en) | 1991-04-17 | 1994-03-08 | Martin Marietta Corporation | Oxide coated metal grid electrode structure in display devices |
US5122925A (en) | 1991-04-22 | 1992-06-16 | Control Products, Inc. | Package for electronic components |
JP3118015B2 (en) | 1991-05-17 | 2000-12-18 | アークレイ株式会社 | Biosensor and separation and quantification method using the same |
US5209229A (en) | 1991-05-20 | 1993-05-11 | Telectronics Pacing Systems, Inc. | Apparatus and method employing plural electrode configurations for cardioversion of atrial fibrillation in an arrhythmia control system |
FI88223C (en) | 1991-05-22 | 1993-04-13 | Polar Electro Oy | Telemetric transmitter unit |
JP2816262B2 (en) | 1991-07-09 | 1998-10-27 | 工業技術院長 | Carbon microsensor electrode and method of manufacturing the same |
US5284156A (en) | 1991-08-30 | 1994-02-08 | M3 Systems, Inc. | Automatic tissue sampling apparatus |
GB9120144D0 (en) | 1991-09-20 | 1991-11-06 | Imperial College | A dialysis electrode device |
US5234835A (en) | 1991-09-26 | 1993-08-10 | C.R. Bard, Inc. | Precalibrated fiber optic sensing method |
US5322063A (en) | 1991-10-04 | 1994-06-21 | Eli Lilly And Company | Hydrophilic polyurethane membranes for electrochemical glucose sensors |
US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
US5217595A (en) | 1991-10-25 | 1993-06-08 | The Yellow Springs Instrument Company, Inc. | Electrochemical gas sensor |
US5415164A (en) | 1991-11-04 | 1995-05-16 | Biofield Corp. | Apparatus and method for screening and diagnosing trauma or disease in body tissues |
DE4139122C1 (en) | 1991-11-28 | 1993-04-08 | Fenzlein, Paul-Gerhard, 8500 Nuernberg, De | |
US5372427A (en) | 1991-12-19 | 1994-12-13 | Texas Instruments Incorporated | Temperature sensor |
US5271815A (en) | 1991-12-26 | 1993-12-21 | Via Medical Corporation | Method for measuring glucose |
US5285792A (en) | 1992-01-10 | 1994-02-15 | Physio-Control Corporation | System for producing prioritized alarm messages in a medical instrument |
US5246867A (en) | 1992-01-17 | 1993-09-21 | University Of Maryland At Baltimore | Determination and quantification of saccharides by luminescence lifetimes and energy transfer |
NL9200207A (en) | 1992-02-05 | 1993-09-01 | Nedap Nv | IMPLANTABLE BIOMEDICAL SENSOR DEVICE, IN PARTICULAR FOR MEASUREMENT OF THE GLUCOSE CONCENTRATION. |
US5328927A (en) | 1992-03-03 | 1994-07-12 | Merck Sharpe & Dohme, Ltd. | Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
US5263244A (en) | 1992-04-17 | 1993-11-23 | Gould Inc. | Method of making a flexible printed circuit sensor assembly for detecting optical pulses |
US5711001A (en) | 1992-05-08 | 1998-01-20 | Motorola, Inc. | Method and circuit for acquisition by a radio receiver |
US6785568B2 (en) | 1992-05-18 | 2004-08-31 | Non-Invasive Technology Inc. | Transcranial examination of the brain |
GB9211402D0 (en) | 1992-05-29 | 1992-07-15 | Univ Manchester | Sensor devices |
US6283761B1 (en) | 1992-09-08 | 2001-09-04 | Raymond Anthony Joao | Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information |
US5400782A (en) | 1992-10-07 | 1995-03-28 | Graphic Controls Corporation | Integral medical electrode including a fusible conductive substrate |
CA2107852C (en) | 1992-10-09 | 2004-09-07 | Gerald Leigh Metcalf | Trocar |
US5421816A (en) | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
US5387327A (en) | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
US5320098A (en) | 1992-10-20 | 1994-06-14 | Sun Microsystems, Inc. | Optical transdermal link |
WO1994010553A1 (en) | 1992-10-23 | 1994-05-11 | Optex Biomedical, Inc. | Fibre-optic probe for the measurement of fluid parameters |
US5918603A (en) | 1994-05-23 | 1999-07-06 | Health Hero Network, Inc. | Method for treating medical conditions using a microprocessor-based video game |
US5601435A (en) | 1994-11-04 | 1997-02-11 | Intercare | Method and apparatus for interactively monitoring a physiological condition and for interactively providing health related information |
US5956501A (en) | 1997-01-10 | 1999-09-21 | Health Hero Network, Inc. | Disease simulation system and method |
US5899855A (en) | 1992-11-17 | 1999-05-04 | Health Hero Network, Inc. | Modular microprocessor-based health monitoring system |
ZA938555B (en) | 1992-11-23 | 1994-08-02 | Lilly Co Eli | Technique to improve the performance of electrochemical sensors |
DK148592D0 (en) | 1992-12-10 | 1992-12-10 | Novo Nordisk As | APPARATUS |
US5299571A (en) | 1993-01-22 | 1994-04-05 | Eli Lilly And Company | Apparatus and method for implantation of sensors |
FR2701117B1 (en) | 1993-02-04 | 1995-03-10 | Asulab Sa | Electrochemical measurement system with multizone sensor, and its application to glucose measurement. |
DE59410388D1 (en) | 1993-04-23 | 2004-10-21 | Roche Diagnostics Gmbh | Floppy disk with test elements arranged in a circle |
US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
DE4318519C2 (en) | 1993-06-03 | 1996-11-28 | Fraunhofer Ges Forschung | Electrochemical sensor |
US5575563A (en) | 1993-07-15 | 1996-11-19 | Chiu; Job | Multiusage thermometer |
DE4329898A1 (en) | 1993-09-04 | 1995-04-06 | Marcus Dr Besson | Wireless medical diagnostic and monitoring device |
US5582184A (en) * | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
US5497772A (en) | 1993-11-19 | 1996-03-12 | Alfred E. Mann Foundation For Scientific Research | Glucose monitoring system |
US5791344A (en) | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
US5724968A (en) | 1993-12-29 | 1998-03-10 | First Opinion Corporation | Computerized medical diagnostic system including meta function |
US5589326A (en) | 1993-12-30 | 1996-12-31 | Boehringer Mannheim Corporation | Osmium-containing redox mediator |
US5320715A (en) | 1994-01-14 | 1994-06-14 | Lloyd Berg | Separation of 1-pentanol from cyclopentanol by extractive distillation |
DE4401400A1 (en) | 1994-01-19 | 1995-07-20 | Ernst Prof Dr Pfeiffer | Method and arrangement for continuously monitoring the concentration of a metabolite |
US5437999A (en) | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
US5543326A (en) | 1994-03-04 | 1996-08-06 | Heller; Adam | Biosensor including chemically modified enzymes |
US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
US5391250A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
US5390671A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Transcutaneous sensor insertion set |
US5484403A (en) * | 1994-04-05 | 1996-01-16 | Avid Marketing, Inc. | Hypodermic syringe for implanting solid objects |
US5609575A (en) | 1994-04-11 | 1997-03-11 | Graseby Medical Limited | Infusion pump and method with dose-rate calculation |
JP3061351B2 (en) | 1994-04-25 | 2000-07-10 | 松下電器産業株式会社 | Method and apparatus for quantifying specific compounds |
US5569186A (en) | 1994-04-25 | 1996-10-29 | Minimed Inc. | Closed loop infusion pump system with removable glucose sensor |
DE4415896A1 (en) | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysis system for monitoring the concentration of an analyte in the blood of a patient |
US5545191A (en) | 1994-05-06 | 1996-08-13 | Alfred E. Mann Foundation For Scientific Research | Method for optimally positioning and securing the external unit of a transcutaneous transducer of the skin of a living body |
US5472317A (en) | 1994-06-03 | 1995-12-05 | Minimed Inc. | Mounting clip for a medication infusion pump |
US5494562A (en) | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
CA2159052C (en) | 1994-10-28 | 2007-03-06 | Rainer Alex | Injection device |
IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5632557A (en) | 1994-12-16 | 1997-05-27 | Weed Instrument Company, Inc. | Modular temperature sensing apparatus |
US5562713A (en) | 1995-01-18 | 1996-10-08 | Pacesetter, Inc. | Bidirectional telemetry apparatus and method for implantable device |
US5551427A (en) | 1995-02-13 | 1996-09-03 | Altman; Peter A. | Implantable device for the effective elimination of cardiac arrhythmogenic sites |
US5568806A (en) | 1995-02-16 | 1996-10-29 | Minimed Inc. | Transcutaneous sensor insertion set |
US5586553A (en) | 1995-02-16 | 1996-12-24 | Minimed Inc. | Transcutaneous sensor insertion set |
US5651869A (en) | 1995-02-28 | 1997-07-29 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
US5596150A (en) | 1995-03-08 | 1997-01-21 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Capacitance probe for fluid flow and volume measurements |
JPH08247987A (en) | 1995-03-15 | 1996-09-27 | Omron Corp | Portable measuring instrument |
US5582697A (en) | 1995-03-17 | 1996-12-10 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
US5788833A (en) | 1995-03-27 | 1998-08-04 | California Institute Of Technology | Sensors for detecting analytes in fluids |
US5752512A (en) | 1995-05-10 | 1998-05-19 | Massachusetts Institute Of Technology | Apparatus and method for non-invasive blood analyte measurement |
US5628310A (en) | 1995-05-19 | 1997-05-13 | Joseph R. Lakowicz | Method and apparatus to perform trans-cutaneous analyte monitoring |
US5567302A (en) | 1995-06-07 | 1996-10-22 | Molecular Devices Corporation | Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change |
US5743262A (en) | 1995-06-07 | 1998-04-28 | Masimo Corporation | Blood glucose monitoring system |
US5584813A (en) | 1995-06-07 | 1996-12-17 | Minimed Inc. | Subcutaneous injection set |
US5638832A (en) | 1995-06-07 | 1997-06-17 | Interval Research Corporation | Programmable subcutaneous visible implant |
US5995860A (en) | 1995-07-06 | 1999-11-30 | Thomas Jefferson University | Implantable sensor and system for measurement and control of blood constituent levels |
US6001065A (en) | 1995-08-02 | 1999-12-14 | Ibva Technologies, Inc. | Method and apparatus for measuring and analyzing physiological signals for active or passive control of physical and virtual spaces and the contents therein |
US5766131A (en) | 1995-08-04 | 1998-06-16 | Seiko Epson Corporation | Pulse-wave measuring apparatus |
US5749656A (en) | 1995-08-11 | 1998-05-12 | General Motors Corporation | Thermal probe assembly with mold-over crimp sensor packaging |
DE19530376C2 (en) | 1995-08-18 | 1999-09-02 | Fresenius Ag | Biosensor |
US5682233A (en) | 1995-09-08 | 1997-10-28 | Integ, Inc. | Interstitial fluid sampler |
IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
DE19534887B4 (en) | 1995-09-20 | 2004-04-15 | Robert Bosch Gmbh | temperature sensor |
US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
US5972199A (en) | 1995-10-11 | 1999-10-26 | E. Heller & Company | Electrochemical analyte sensors using thermostable peroxidase |
US5665222A (en) | 1995-10-11 | 1997-09-09 | E. Heller & Company | Soybean peroxidase electrochemical sensor |
US5741211A (en) | 1995-10-26 | 1998-04-21 | Medtronic, Inc. | System and method for continuous monitoring of diabetes-related blood constituents |
US5711861A (en) | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
ZA9610374B (en) | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
US5827184A (en) | 1995-12-29 | 1998-10-27 | Minnesota Mining And Manufacturing Company | Self-packaging bioelectrodes |
US5746697A (en) | 1996-02-09 | 1998-05-05 | Nellcor Puritan Bennett Incorporated | Medical diagnostic apparatus with sleep mode |
FI960636A (en) | 1996-02-12 | 1997-08-13 | Nokia Mobile Phones Ltd | A procedure for monitoring the health of a patient |
FI118509B (en) | 1996-02-12 | 2007-12-14 | Nokia Oyj | A method and apparatus for predicting blood glucose levels in a patient |
US5708247A (en) | 1996-02-14 | 1998-01-13 | Selfcare, Inc. | Disposable glucose test strips, and methods and compositions for making same |
AU2052997A (en) | 1996-02-23 | 1997-09-10 | Diasense, Inc. | Method and apparatus for non-invasive blood glucose sensing |
EP0898468B1 (en) | 1996-04-08 | 2003-10-15 | Medtronic, Inc. | Method of fixing a physiologic mitral valve bioprosthesis |
DE19618597B4 (en) | 1996-05-09 | 2005-07-21 | Institut für Diabetestechnologie Gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm | Method for determining the concentration of tissue glucose |
ES2121564B1 (en) * | 1996-05-17 | 2001-02-01 | Mercury Diagnostics Inc | METHODS AND APPLIANCES TO EXTRACT BODY FLUID FROM AN INCISION. |
EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US5951492A (en) | 1996-05-17 | 1999-09-14 | Mercury Diagnostics, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US5954685A (en) | 1996-05-24 | 1999-09-21 | Cygnus, Inc. | Electrochemical sensor with dual purpose electrode |
US5735285A (en) | 1996-06-04 | 1998-04-07 | Data Critical Corp. | Method and hand-held apparatus for demodulating and viewing frequency modulated biomedical signals |
US5613978A (en) | 1996-06-04 | 1997-03-25 | Palco Laboratories | Adjustable tip for lancet device |
ZA975326B (en) | 1996-06-18 | 1998-01-14 | Alza Corp | Device and method for enhancing transdermal flux of agents being delivered or sampled. |
IL127213A (en) | 1996-07-08 | 2003-09-17 | Animas Corp | Implantable sensor and system for in vivo measurement and control of fluid constituent levels |
US5738220A (en) | 1996-09-30 | 1998-04-14 | Pacesetter, Inc. | Distal tip protector cap |
US5771001A (en) | 1996-11-18 | 1998-06-23 | Cobb; Marlon J. | Personal alarm system |
US6004278A (en) | 1996-12-05 | 1999-12-21 | Mdc Investment Holdings, Inc. | Fluid collection device with retractable needle |
US6071251A (en) | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US5964993A (en) | 1996-12-19 | 1999-10-12 | Implanted Biosystems Inc. | Glucose sensor |
US6122351A (en) | 1997-01-21 | 2000-09-19 | Med Graph, Inc. | Method and system aiding medical diagnosis and treatment |
US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US5851197A (en) | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
US6093172A (en) | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
US7329239B2 (en) | 1997-02-05 | 2008-02-12 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US20070142776A9 (en) | 1997-02-05 | 2007-06-21 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
AU6157898A (en) | 1997-02-06 | 1998-08-26 | E. Heller & Company | Small volume (in vitro) analyte sensor |
WO1998037805A1 (en) | 1997-02-26 | 1998-09-03 | Diasense, Inc. | Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose |
US6159147A (en) | 1997-02-28 | 2000-12-12 | Qrs Diagnostics, Llc | Personal computer card for collection of real-time biological data |
US6558321B1 (en) | 1997-03-04 | 2003-05-06 | Dexcom, Inc. | Systems and methods for remote monitoring and modulation of medical devices |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US6741877B1 (en) | 1997-03-04 | 2004-05-25 | Dexcom, Inc. | Device and method for determining analyte levels |
US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
US7885697B2 (en) | 2004-07-13 | 2011-02-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US7657297B2 (en) | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US6554795B2 (en) | 1997-03-06 | 2003-04-29 | Medtronic Ave, Inc. | Balloon catheter and method of manufacture |
US6270455B1 (en) | 1997-03-28 | 2001-08-07 | Health Hero Network, Inc. | Networked system for interactive communications and remote monitoring of drug delivery |
US6026321A (en) | 1997-04-02 | 2000-02-15 | Suzuki Motor Corporation | Apparatus and system for measuring electrical potential variations in human body |
US5961451A (en) | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US5987353A (en) | 1997-04-10 | 1999-11-16 | Khatchatrian; Robert G. | Diagnostic complex for measurement of the condition of biological tissues and liquids |
US6059946A (en) | 1997-04-14 | 2000-05-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
US6186982B1 (en) | 1998-05-05 | 2001-02-13 | Elan Corporation, Plc | Subcutaneous drug delivery device with improved filling system |
US5779665A (en) | 1997-05-08 | 1998-07-14 | Minimed Inc. | Transdermal introducer assembly |
US5954643A (en) | 1997-06-09 | 1999-09-21 | Minimid Inc. | Insertion set for a transcutaneous sensor |
US7267665B2 (en) | 1999-06-03 | 2007-09-11 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
US5865804A (en) | 1997-07-16 | 1999-02-02 | Bachynsky; Nicholas | Rotary cam syringe |
US6232950B1 (en) | 1997-08-28 | 2001-05-15 | E Ink Corporation | Rear electrode structures for displays |
US6764581B1 (en) | 1997-09-05 | 2004-07-20 | Abbott Laboratories | Electrode with thin working layer |
US6071391A (en) | 1997-09-12 | 2000-06-06 | Nok Corporation | Enzyme electrode structure |
US6117290A (en) | 1997-09-26 | 2000-09-12 | Pepex Biomedical, Llc | System and method for measuring a bioanalyte such as lactate |
US20020013538A1 (en) | 1997-09-30 | 2002-01-31 | David Teller | Method and apparatus for health signs monitoring |
US5904671A (en) | 1997-10-03 | 1999-05-18 | Navot; Nir | Tampon wetness detection system |
US5938679A (en) | 1997-10-14 | 1999-08-17 | Hewlett-Packard Company | Apparatus and method for minimally invasive blood sampling |
US6736957B1 (en) | 1997-10-16 | 2004-05-18 | Abbott Laboratories | Biosensor electrode mediators for regeneration of cofactors and process for using |
US6088608A (en) | 1997-10-20 | 2000-07-11 | Alfred E. Mann Foundation | Electrochemical sensor and integrity tests therefor |
US6119028A (en) | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
FI107080B (en) | 1997-10-27 | 2001-05-31 | Nokia Mobile Phones Ltd | measuring device |
AU1401599A (en) | 1997-11-12 | 1999-05-31 | Lightouch Medical, Inc. | Method for non-invasive measurement of an analyte |
US6068399A (en) | 1997-11-12 | 2000-05-30 | K-Jump Health Co., Ltd. | Cost-effective electronic thermometer |
US6482176B1 (en) | 1997-11-27 | 2002-11-19 | Disetronic Licensing Ag | Method and device for controlling the introduction depth of an injection needle |
US6071294A (en) | 1997-12-04 | 2000-06-06 | Agilent Technologies, Inc. | Lancet cartridge for sampling blood |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US5971941A (en) | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
US5871494A (en) | 1997-12-04 | 1999-02-16 | Hewlett-Packard Company | Reproducible lancing for sampling blood |
US6579690B1 (en) | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
CA2575064C (en) | 1997-12-31 | 2010-02-02 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
DE69842210D1 (en) | 1997-12-31 | 2011-05-12 | Medtronic Minimed Inc | Introducer And Introducer Set |
US6804543B2 (en) | 1998-02-05 | 2004-10-12 | Hema Metrics, Inc. | Sensor for transcutaneous measurement of vascular access blood flow |
US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
US6134461A (en) | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
US6056718A (en) | 1998-03-04 | 2000-05-02 | Minimed Inc. | Medication infusion set |
US6024699A (en) | 1998-03-13 | 2000-02-15 | Healthware Corporation | Systems, methods and computer program products for monitoring, diagnosing and treating medical conditions of remotely located patients |
US6197181B1 (en) | 1998-03-20 | 2001-03-06 | Semitool, Inc. | Apparatus and method for electrolytically depositing a metal on a microelectronic workpiece |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6728560B2 (en) | 1998-04-06 | 2004-04-27 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
JPH11296598A (en) | 1998-04-07 | 1999-10-29 | Seizaburo Arita | System and method for predicting blood-sugar level and record medium where same method is recorded |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
GB2337122B (en) | 1998-05-08 | 2002-11-13 | Medisense Inc | Test strip |
PT1077636E (en) | 1998-05-13 | 2004-06-30 | Cygnus Therapeutic Systems | SIGNAL PROCESSING FOR PHYSIOLOGICAL ANALYZES MEDICATION |
DE19821723C2 (en) | 1998-05-14 | 2000-07-06 | Disetronic Licensing Ag | Catheter head for subcutaneous administration of an active ingredient |
US6121611A (en) | 1998-05-20 | 2000-09-19 | Molecular Imaging Corporation | Force sensing probe for scanning probe microscopy |
US5951582A (en) | 1998-05-22 | 1999-09-14 | Specialized Health Products, Inc. | Lancet apparatus and methods |
US6837885B2 (en) | 1998-05-22 | 2005-01-04 | Scimed Life Systems, Inc. | Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors |
GB9812472D0 (en) | 1998-06-11 | 1998-08-05 | Owen Mumford Ltd | A dose setting device for medical injectors |
US6458109B1 (en) | 1998-08-07 | 2002-10-01 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6554798B1 (en) | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
US5993423A (en) | 1998-08-18 | 1999-11-30 | Choi; Soo Bong | Portable automatic syringe device and injection needle unit thereof |
US6248067B1 (en) | 1999-02-05 | 2001-06-19 | Minimed Inc. | Analyte sensor and holter-type monitor system and method of using the same |
US5951521A (en) | 1998-09-25 | 1999-09-14 | Minimed Inc. | Subcutaneous implantable sensor set having the capability to remove deliver fluids to an insertion site |
US6254586B1 (en) | 1998-09-25 | 2001-07-03 | Minimed Inc. | Method and kit for supplying a fluid to a subcutaneous placement site |
WO2000018289A1 (en) | 1998-09-30 | 2000-04-06 | Cygnus, Inc. | Method and device for predicting physiological values |
EP1119285A1 (en) | 1998-10-08 | 2001-08-01 | Minimed Inc. | Telemetered characteristic monitor system |
US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6591125B1 (en) | 2000-06-27 | 2003-07-08 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US5948006A (en) | 1998-10-14 | 1999-09-07 | Advanced Bionics Corporation | Transcutaneous transmission patch |
EP1131114B1 (en) | 1998-11-20 | 2004-06-16 | The University of Connecticut | Apparatus and method for control of tissue/implant interactions |
US6773671B1 (en) | 1998-11-30 | 2004-08-10 | Abbott Laboratories | Multichemistry measuring device and test strips |
BR9915778A (en) | 1998-11-30 | 2001-08-14 | Abbott Lab | Processes to calibrate and operate an analyte test instrument, to determine the actual date and time of events on an analyte test instrument, and to control the operation of an analyte test instrument |
US6022368A (en) | 1998-11-30 | 2000-02-08 | Gavronsky; Stas | Acupuncture method and device |
US6161095A (en) | 1998-12-16 | 2000-12-12 | Health Hero Network, Inc. | Treatment regimen compliance and efficacy with feedback |
US6433728B1 (en) | 1999-01-22 | 2002-08-13 | Lear Automotive Dearborn, Inc. | Integrally molded remote entry transmitter |
EP1135052A1 (en) | 1999-02-12 | 2001-09-26 | Cygnus, Inc. | Devices and methods for frequent measurement of an analyte present in a biological system |
US6360888B1 (en) | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
JP4801839B2 (en) | 1999-02-25 | 2011-10-26 | メドトロニック ミニメド インコーポレイテッド | Test plug and cable for glucose monitor |
US6424847B1 (en) | 1999-02-25 | 2002-07-23 | Medtronic Minimed, Inc. | Glucose monitor calibration methods |
US6132449A (en) * | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
US6959211B2 (en) | 1999-03-10 | 2005-10-25 | Optiscan Biomedical Corp. | Device for capturing thermal spectra from tissue |
GB9907815D0 (en) | 1999-04-06 | 1999-06-02 | Univ Cambridge Tech | Implantable sensor |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6200265B1 (en) | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
US6669663B1 (en) | 1999-04-30 | 2003-12-30 | Medtronic, Inc. | Closed loop medicament pump |
FR2793021B1 (en) | 1999-04-30 | 2001-08-03 | Siemens Automotive Sa | TEMPERATURE SENSOR AND METHOD FOR MANUFACTURING SUCH A SENSOR |
US6359444B1 (en) | 1999-05-28 | 2002-03-19 | University Of Kentucky Research Foundation | Remote resonant-circuit analyte sensing apparatus with sensing structure and associated method of sensing |
US6546268B1 (en) | 1999-06-02 | 2003-04-08 | Ball Semiconductor, Inc. | Glucose sensor |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6423035B1 (en) | 1999-06-18 | 2002-07-23 | Animas Corporation | Infusion pump with a sealed drive mechanism and improved method of occlusion detection |
GB2351153B (en) | 1999-06-18 | 2003-03-26 | Abbott Lab | Electrochemical sensor for analysis of liquid samples |
EP1192269A2 (en) | 1999-06-18 | 2002-04-03 | Therasense, Inc. | MASS TRANSPORT LIMITED i IN VIVO /i ANALYTE SENSOR |
US6368274B1 (en) | 1999-07-01 | 2002-04-09 | Medtronic Minimed, Inc. | Reusable analyte sensor site and method of using the same |
US6168606B1 (en) | 1999-11-10 | 2001-01-02 | Palco Labs, Inc. | Single-use lancet device |
US6413393B1 (en) | 1999-07-07 | 2002-07-02 | Minimed, Inc. | Sensor including UV-absorbing polymer and method of manufacture |
US6514460B1 (en) | 1999-07-28 | 2003-02-04 | Abbott Laboratories | Luminous glucose monitoring device |
US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
AT408182B (en) | 1999-09-17 | 2001-09-25 | Schaupp Lukas Dipl Ing Dr Tech | DEVICE FOR VIVO MEASURING SIZES IN LIVING ORGANISMS |
EP1217942A1 (en) | 1999-09-24 | 2002-07-03 | Healthetech, Inc. | Physiological monitor and associated computation, display and communication unit |
JP2004513669A (en) | 1999-10-08 | 2004-05-13 | ヘルセテック インコーポレイテッド | Integrated calorie management system |
DE19948759A1 (en) | 1999-10-09 | 2001-04-12 | Roche Diagnostics Gmbh | Blood lancet device for drawing blood for diagnostic purposes |
US6283982B1 (en) | 1999-10-19 | 2001-09-04 | Facet Technologies, Inc. | Lancing device and method of sample collection |
US6616819B1 (en) | 1999-11-04 | 2003-09-09 | Therasense, Inc. | Small volume in vitro analyte sensor and methods |
US20060091006A1 (en) | 1999-11-04 | 2006-05-04 | Yi Wang | Analyte sensor with insertion monitor, and methods |
JP3985022B2 (en) | 1999-11-08 | 2007-10-03 | アークレイ株式会社 | Body fluid measuring device and insertion body used by being inserted into the body fluid measuring device |
DE60011286T2 (en) | 1999-11-15 | 2005-07-14 | Therasense, Inc., Alameda | TRANSITION METAL COMPLEX COMPOUNDS WITH A BIDENTATE LIGANDE WITH AN IMIDAZOLE RING |
MXPA02005068A (en) * | 1999-11-19 | 2002-11-07 | Spectrx Inc | Tissue interface device. |
GB9927842D0 (en) | 1999-11-26 | 2000-01-26 | Koninkl Philips Electronics Nv | Improved fabric antenna |
US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
WO2001041643A1 (en) | 1999-12-13 | 2001-06-14 | Arkray, Inc. | Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus |
US7369635B2 (en) | 2000-01-21 | 2008-05-06 | Medtronic Minimed, Inc. | Rapid discrimination preambles and methods for using the same |
WO2001054753A2 (en) | 2000-01-21 | 2001-08-02 | Medical Research Group, Inc. | Microprocessor controlled ambulatory medical apparatus with hand held communication device |
DK1248661T3 (en) | 2000-01-21 | 2012-11-26 | Medtronic Minimed Inc | Medical device for outpatient use and method of control software that can be modified by telemetry |
US6694191B2 (en) | 2000-01-21 | 2004-02-17 | Medtronic Minimed, Inc. | Ambulatory medical apparatus and method having telemetry modifiable control software |
US6484045B1 (en) | 2000-02-10 | 2002-11-19 | Medtronic Minimed, Inc. | Analyte sensor and method of making the same |
US7003336B2 (en) | 2000-02-10 | 2006-02-21 | Medtronic Minimed, Inc. | Analyte sensor method of making the same |
US6895263B2 (en) | 2000-02-23 | 2005-05-17 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
US6706159B2 (en) | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
US6551496B1 (en) | 2000-03-03 | 2003-04-22 | Ysi Incorporated | Microstructured bilateral sensor |
DE10010587A1 (en) | 2000-03-03 | 2001-09-06 | Roche Diagnostics Gmbh | System for the determination of analyte concentrations in body fluids |
US6435017B1 (en) | 2000-03-16 | 2002-08-20 | Motorola, Inc. | Snap-fit sensing apparatus |
US6610012B2 (en) | 2000-04-10 | 2003-08-26 | Healthetech, Inc. | System and method for remote pregnancy monitoring |
US20010034479A1 (en) | 2000-04-19 | 2001-10-25 | Ring Lawrence S. | Optically based transcutaneous blood gas sensor |
US6440068B1 (en) | 2000-04-28 | 2002-08-27 | International Business Machines Corporation | Measuring user health as measured by multiple diverse health measurement devices utilizing a personal storage device |
US7404815B2 (en) | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
WO2001088524A1 (en) | 2000-05-12 | 2001-11-22 | Therasense, Inc. | Electrodes with multilayer membranes and methods of using and making the electrodes |
US6442413B1 (en) | 2000-05-15 | 2002-08-27 | James H. Silver | Implantable sensor |
US7181261B2 (en) | 2000-05-15 | 2007-02-20 | Silver James H | Implantable, retrievable, thrombus minimizing sensors |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
US7530964B2 (en) | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
DE60133653T2 (en) | 2000-08-18 | 2009-06-04 | Animas Technologies Llc | APPARATUS FOR PREDICTING HYPOGLYECURE DROPS |
WO2002017210A2 (en) | 2000-08-18 | 2002-02-28 | Cygnus, Inc. | Formulation and manipulation of databases of analyte and associated values |
EP1311189A4 (en) | 2000-08-21 | 2005-03-09 | Euro Celtique Sa | Near infrared blood glucose monitoring system |
US6827899B2 (en) | 2000-08-30 | 2004-12-07 | Hypoguard Limited | Test device |
CA2421133C (en) | 2000-09-08 | 2012-06-26 | Insulet Corporation | Devices, systems and methods for patient infusion |
US6712025B2 (en) | 2000-10-13 | 2004-03-30 | Dogwatch, Inc. | Receiver/stimulus unit for an animal control system |
CA2426330A1 (en) | 2000-11-01 | 2002-05-10 | 3M Innovative Properties Company | Electrical sensing and/or signal application device |
US6695860B1 (en) | 2000-11-13 | 2004-02-24 | Isense Corp. | Transcutaneous sensor insertion device |
ES2574917T3 (en) | 2000-11-30 | 2016-06-23 | Valeritas, Inc. | Fluid supply and measurement systems and procedures |
US6439446B1 (en) | 2000-12-01 | 2002-08-27 | Stephen J. Perry | Safety lockout for actuator shaft |
US20020072720A1 (en) | 2000-12-11 | 2002-06-13 | Hague Clifford W. | Rigid soluble materials for use with needle-less infusion sets, sensor sets and injection devices and methods of making the same |
US7052483B2 (en) | 2000-12-19 | 2006-05-30 | Animas Corporation | Transcutaneous inserter for low-profile infusion sets |
GB0030929D0 (en) | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
US6416332B1 (en) | 2000-12-20 | 2002-07-09 | Nortel Networks Limited | Direct BGA socket for high speed use |
EP1353594B1 (en) | 2000-12-29 | 2008-10-29 | Ares Medical, Inc. | Sleep apnea risk evaluation |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
WO2002056769A1 (en) | 2001-01-19 | 2002-07-25 | Matsushita Electric Industrial Co., Ltd. | Lancet-integrated sensor, measurer for lancet-integrated sensor, and cartridge |
JP2004522500A (en) | 2001-01-22 | 2004-07-29 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | Lancet device with capillary action |
US6749587B2 (en) | 2001-02-22 | 2004-06-15 | Insulet Corporation | Modular infusion device and method |
US20030023461A1 (en) | 2001-03-14 | 2003-01-30 | Dan Quintanilla | Internet based therapy management system |
US6968294B2 (en) | 2001-03-15 | 2005-11-22 | Koninklijke Philips Electronics N.V. | Automatic system for monitoring person requiring care and his/her caretaker |
US7041468B2 (en) | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
JP4450556B2 (en) | 2001-04-06 | 2010-04-14 | ディセトロニック・ライセンシング・アクチェンゲゼルシャフト | Injection device |
US6535764B2 (en) | 2001-05-01 | 2003-03-18 | Intrapace, Inc. | Gastric treatment and diagnosis device and method |
JP2004532526A (en) | 2001-05-03 | 2004-10-21 | マシモ・コーポレイション | Flex circuit shield optical sensor and method of manufacturing the flex circuit shield optical sensor |
US6613379B2 (en) | 2001-05-08 | 2003-09-02 | Isense Corp. | Implantable analyte sensor |
US6932894B2 (en) | 2001-05-15 | 2005-08-23 | Therasense, Inc. | Biosensor membranes composed of polymers containing heterocyclic nitrogens |
US6837988B2 (en) | 2001-06-12 | 2005-01-04 | Lifescan, Inc. | Biological fluid sampling and analyte measurement devices and methods |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US7179226B2 (en) | 2001-06-21 | 2007-02-20 | Animas Corporation | System and method for managing diabetes |
WO2003000141A1 (en) | 2001-06-25 | 2003-01-03 | Abbott Laboratories | Apparatus and methods for performing an anastomosis |
WO2003005907A1 (en) | 2001-07-11 | 2003-01-23 | Arkray, Inc. | Lancet and piercing device |
US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
US6544212B2 (en) | 2001-07-31 | 2003-04-08 | Roche Diagnostics Corporation | Diabetes management system |
US6827718B2 (en) | 2001-08-14 | 2004-12-07 | Scimed Life Systems, Inc. | Method of and apparatus for positioning and maintaining the position of endoscopic instruments |
JP2004538078A (en) | 2001-08-20 | 2004-12-24 | インバネス・メディカル・リミテッド | Wireless diabetes management device and method of using wireless diabetes management device |
US6740072B2 (en) | 2001-09-07 | 2004-05-25 | Medtronic Minimed, Inc. | System and method for providing closed loop infusion formulation delivery |
US7025760B2 (en) | 2001-09-07 | 2006-04-11 | Medtronic Minimed, Inc. | Method and system for non-vascular sensor implantation |
JP2003084101A (en) | 2001-09-17 | 2003-03-19 | Dainippon Printing Co Ltd | Resin composition for optical device, optical device and projection screen |
US20030055380A1 (en) | 2001-09-19 | 2003-03-20 | Flaherty J. Christopher | Plunger for patient infusion device |
US7052591B2 (en) | 2001-09-21 | 2006-05-30 | Therasense, Inc. | Electrodeposition of redox polymers and co-electrodeposition of enzymes by coordinative crosslinking |
US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US6613015B2 (en) | 2001-10-04 | 2003-09-02 | Deltec, Inc. | Right angle safety needle |
US20030069510A1 (en) | 2001-10-04 | 2003-04-10 | Semler Herbert J. | Disposable vital signs monitor |
US6748254B2 (en) | 2001-10-12 | 2004-06-08 | Nellcor Puritan Bennett Incorporated | Stacked adhesive optical sensor |
US7010356B2 (en) | 2001-10-31 | 2006-03-07 | London Health Sciences Centre Research Inc. | Multichannel electrode and methods of using same |
US6971999B2 (en) | 2001-11-14 | 2005-12-06 | Medical Instill Technologies, Inc. | Intradermal delivery device and method |
US20030145062A1 (en) | 2002-01-14 | 2003-07-31 | Dipanshu Sharma | Data conversion server for voice browsing system |
US20030155656A1 (en) | 2002-01-18 | 2003-08-21 | Chiu Cindy Chia-Wen | Anisotropically conductive film |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
DE10208575C1 (en) | 2002-02-21 | 2003-08-14 | Hartmann Paul Ag | Blood analyzer device comprises needles, test media, analyzer and display, and has carrier turned with respect to main body, to position needle and test media |
AU2003213638A1 (en) | 2002-02-26 | 2003-09-09 | Sterling Medivations, Inc. | Insertion device for an insertion set and method of using the same |
US20030212379A1 (en) | 2002-02-26 | 2003-11-13 | Bylund Adam David | Systems and methods for remotely controlling medication infusion and analyte monitoring |
DE10392369B4 (en) | 2002-03-06 | 2011-12-15 | HTL-STREFA Spólka z o. o. | Device for puncturing the skin of a patient |
US6998247B2 (en) | 2002-03-08 | 2006-02-14 | Sensys Medical, Inc. | Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers |
US6936006B2 (en) | 2002-03-22 | 2005-08-30 | Novo Nordisk, A/S | Atraumatic insertion of a subcutaneous device |
GB2388898B (en) | 2002-04-02 | 2005-10-05 | Inverness Medical Ltd | Integrated sample testing meter |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7141058B2 (en) | 2002-04-19 | 2006-11-28 | Pelikan Technologies, Inc. | Method and apparatus for a body fluid sampling device using illumination |
US7485128B2 (en) | 2002-04-19 | 2009-02-03 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7410468B2 (en) | 2002-04-19 | 2008-08-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US6758835B2 (en) | 2002-05-01 | 2004-07-06 | Medtg, Llc | Disposable needle assembly having sensors formed therein permitting the simultaneous drawing and administering of fluids and method of forming the same |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US8641715B2 (en) | 2002-05-31 | 2014-02-04 | Vidacare Corporation | Manual intraosseous device |
US20030236489A1 (en) | 2002-06-21 | 2003-12-25 | Baxter International, Inc. | Method and apparatus for closed-loop flow control system |
AU2003246222A1 (en) | 2002-07-02 | 2004-01-23 | Arkray, Inc. | Unit for piercing, and piercing device |
US6865454B2 (en) | 2002-07-02 | 2005-03-08 | Quantum Engineering Inc. | Train control system and method of controlling a train or trains |
US20040010207A1 (en) | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
US7018360B2 (en) | 2002-07-16 | 2006-03-28 | Insulet Corporation | Flow restriction system and method for patient infusion device |
CA2492959A1 (en) | 2002-07-19 | 2004-07-15 | Smiths Detection-Pasadena, Inc. | Non-specific sensor array detectors |
US7058719B2 (en) | 2002-07-22 | 2006-06-06 | Ricoh Company, Ltd. | System, computer program product and method for managing and controlling a local network of electronic devices and reliably and securely adding an electronic device to the network |
US7278983B2 (en) | 2002-07-24 | 2007-10-09 | Medtronic Minimed, Inc. | Physiological monitoring device for controlling a medication infusion device |
JP2005538773A (en) | 2002-09-12 | 2005-12-22 | チルドレンズ ホスピタル メディカル センター | Method and apparatus for injecting drugs without pain |
US7736309B2 (en) | 2002-09-27 | 2010-06-15 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US7192405B2 (en) | 2002-09-30 | 2007-03-20 | Becton, Dickinson And Company | Integrated lancet and bodily fluid sensor |
AU2003269844A1 (en) | 2002-10-07 | 2004-04-23 | Novo Nordisk A/S | Needle device comprising a plurality of needles |
TW557352B (en) | 2002-10-07 | 2003-10-11 | Actherm Inc | Electronic clinical thermometer with rapid response |
US7014625B2 (en) | 2002-10-07 | 2006-03-21 | Novo Nordick A/S | Needle insertion device |
CA2501512A1 (en) | 2002-10-09 | 2004-04-22 | Csp Technologies, Inc. | Lancet system including test strips and cassettes |
US7060059B2 (en) | 2002-10-11 | 2006-06-13 | Becton, Dickinson And Company | System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device |
US7381184B2 (en) | 2002-11-05 | 2008-06-03 | Abbott Diabetes Care Inc. | Sensor inserter assembly |
US7572237B2 (en) | 2002-11-06 | 2009-08-11 | Abbott Diabetes Care Inc. | Automatic biological analyte testing meter with integrated lancing device and methods of use |
US6676290B1 (en) | 2002-11-15 | 2004-01-13 | Hsueh-Yu Lu | Electronic clinical thermometer |
AU2003289047A1 (en) | 2002-12-13 | 2004-07-09 | Arkray, Inc. | Needle-insertion device |
WO2004058321A2 (en) | 2002-12-16 | 2004-07-15 | Meagan Medical, Inc. | Controlling the depth of percutaneous applications |
US20040116866A1 (en) | 2002-12-17 | 2004-06-17 | William Gorman | Skin attachment apparatus and method for patient infusion device |
US20040122353A1 (en) | 2002-12-19 | 2004-06-24 | Medtronic Minimed, Inc. | Relay device for transferring information between a sensor system and a fluid delivery system |
US7395117B2 (en) | 2002-12-23 | 2008-07-01 | Cardiac Pacemakers, Inc. | Implantable medical device having long-term wireless capabilities |
US20040127818A1 (en) | 2002-12-27 | 2004-07-01 | Roe Steven N. | Precision depth control lancing tip |
US8771183B2 (en) | 2004-02-17 | 2014-07-08 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
AU2003303597A1 (en) | 2002-12-31 | 2004-07-29 | Therasense, Inc. | Continuous glucose monitoring system and methods of use |
US20040138544A1 (en) | 2003-01-13 | 2004-07-15 | Ward W. Kenneth | Body fluid trap anlyte sensor |
US7120483B2 (en) * | 2003-01-13 | 2006-10-10 | Isense Corporation | Methods for analyte sensing and measurement |
CN100398062C (en) | 2003-01-17 | 2008-07-02 | 松下电器产业株式会社 | Biological component measuring device |
US20040140211A1 (en) | 2003-01-21 | 2004-07-22 | Broy Stephen H. | Modular interface and coupling system and method |
US20040171910A1 (en) | 2003-02-27 | 2004-09-02 | Moore-Steele Robin B. | Sexually stimulating panty insert |
US20040186373A1 (en) | 2003-03-21 | 2004-09-23 | Dunfield John Stephen | Method and device for targeted epithelial delivery of medicinal and related agents |
US20050070819A1 (en) | 2003-03-31 | 2005-03-31 | Rosedale Medical, Inc. | Body fluid sampling constructions and techniques |
US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
JP4621853B2 (en) | 2003-04-11 | 2011-01-26 | アークレイ株式会社 | Puncture device |
US6797877B1 (en) | 2003-04-28 | 2004-09-28 | Jonn Maneely Company | Electrical metallic tube, coupling, and connector apparatus and method |
EP1475113A1 (en) | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | External needle inserter |
EP1624913B1 (en) | 2003-05-08 | 2010-07-21 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation portion |
US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
JP2006527059A (en) | 2003-06-09 | 2006-11-30 | グルコン インク | Wearable glucometer |
US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
US20040254433A1 (en) | 2003-06-12 | 2004-12-16 | Bandis Steven D. | Sensor introducer system, apparatus and method |
ES2293273T3 (en) | 2003-06-12 | 2008-03-16 | Disetronic Licensing Ag | INSERTION DEVICE FOR INFUSION EQUIPMENT. |
WO2004112602A1 (en) | 2003-06-13 | 2004-12-29 | Pelikan Technologies, Inc. | Method and apparatus for a point of care device |
US7146202B2 (en) * | 2003-06-16 | 2006-12-05 | Isense Corporation | Compound material analyte sensor |
JP4041018B2 (en) | 2003-06-25 | 2008-01-30 | Tdk株式会社 | Temperature sensor |
US7510564B2 (en) | 2003-06-27 | 2009-03-31 | Abbott Diabetes Care Inc. | Lancing device |
US7424318B2 (en) | 2003-12-05 | 2008-09-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8423113B2 (en) | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
US7761130B2 (en) | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US7460898B2 (en) | 2003-12-05 | 2008-12-02 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US20050176136A1 (en) | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
US8282549B2 (en) | 2003-12-09 | 2012-10-09 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
WO2005012873A2 (en) | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Electrode systems for electrochemical sensors |
US7366556B2 (en) | 2003-12-05 | 2008-04-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
EP1648298A4 (en) | 2003-07-25 | 2010-01-13 | Dexcom Inc | Oxygen enhancing membrane systems for implantable devices |
US7467003B2 (en) | 2003-12-05 | 2008-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
WO2005019795A2 (en) | 2003-07-25 | 2005-03-03 | Dexcom, Inc. | Electrochemical sensors including electrode systems with increased oxygen generation |
US8060173B2 (en) | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8788006B2 (en) | 2003-08-01 | 2014-07-22 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7959569B2 (en) | 2003-08-01 | 2011-06-14 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US8369919B2 (en) | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
DE10336933B4 (en) | 2003-08-07 | 2007-04-26 | Roche Diagnostics Gmbh | Blood Collection system |
US7905898B2 (en) * | 2003-08-15 | 2011-03-15 | Stat Medical Devices, Inc. | Adjustable lancet device and method |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US7097637B2 (en) | 2003-08-27 | 2006-08-29 | C. R. Bard, Inc. | Safety needle with positive flush |
US7497940B2 (en) | 2003-09-02 | 2009-03-03 | Koji Sode | Glucose sensor and glucose level measuring apparatus |
JP2007503958A (en) | 2003-09-03 | 2007-03-01 | ライフパッチ インターナショナル,インコーポレイテッド | Personal diagnostic equipment and related methods |
JP4356088B2 (en) | 2003-09-26 | 2009-11-04 | 日本光電工業株式会社 | Telemeter system for multi-channel biological signals |
WO2005037184A2 (en) | 2003-10-21 | 2005-04-28 | Novo Nordisk A/S | Reservoir device with integrated mounting means |
US20050090607A1 (en) | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
US6928380B2 (en) | 2003-10-30 | 2005-08-09 | International Business Machines Corporation | Thermal measurements of electronic devices during operation |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
JP2005137416A (en) | 2003-11-04 | 2005-06-02 | Sysmex Corp | Percutaneous analyte extraction system and percutaneous analyte analysis system |
US7699807B2 (en) | 2003-11-10 | 2010-04-20 | Smiths Medical Asd, Inc. | Device and method for insertion of a cannula of an infusion device |
JP2007510524A (en) | 2003-11-12 | 2007-04-26 | ファセット・テクノロジーズ・エルエルシー | Puncture device and multi-lancet cartridge |
DK1691679T3 (en) | 2003-11-13 | 2010-11-22 | Medtronic Minimed Inc | Long-term analyzer sensor device |
WO2005051170A2 (en) | 2003-11-19 | 2005-06-09 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US20100185071A1 (en) | 2003-12-05 | 2010-07-22 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8364230B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US20080200788A1 (en) | 2006-10-04 | 2008-08-21 | Dexcorn, Inc. | Analyte sensor |
EP1711790B1 (en) | 2003-12-05 | 2010-09-08 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
US8425417B2 (en) | 2003-12-05 | 2013-04-23 | Dexcom, Inc. | Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device |
US20080197024A1 (en) | 2003-12-05 | 2008-08-21 | Dexcom, Inc. | Analyte sensor |
US8425416B2 (en) | 2006-10-04 | 2013-04-23 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
DE602004028164D1 (en) | 2003-12-08 | 2010-08-26 | Dexcom Inc | SYSTEMS AND METHOD FOR IMPROVING ELECTROCHEMICAL ANALYTIC SENSORS |
US7763042B2 (en) | 2003-12-16 | 2010-07-27 | Panasonic Corporation | Lancet for blood collection and puncture needle unit |
CA2554232C (en) * | 2003-12-22 | 2013-07-09 | Paul Hadvary | Dermallly affixed sensor device |
US7449024B2 (en) | 2003-12-23 | 2008-11-11 | Abbott Laboratories | Suturing device with split arm and method of suturing tissue |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US7637868B2 (en) | 2004-01-12 | 2009-12-29 | Dexcom, Inc. | Composite material for implantable device |
US8465696B2 (en) | 2004-02-03 | 2013-06-18 | Polymer Technology Systems, Inc. | Dry test strip with controlled flow and method of manufacturing same |
US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
WO2005079257A2 (en) | 2004-02-12 | 2005-09-01 | Dexcom, Inc. | Biointerface with macro- and micro- architecture |
JP2007526807A (en) | 2004-02-23 | 2007-09-20 | エシコン・インコーポレイテッド | Diagnostic test equipment |
JP4593129B2 (en) | 2004-02-26 | 2010-12-08 | オリンパス株式会社 | Endoscope |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
WO2005084257A2 (en) | 2004-02-26 | 2005-09-15 | Vpn Solutions, Llc | Composite thin-film glucose sensor |
EP1722692B1 (en) | 2004-03-02 | 2017-08-23 | Facet Technologies, LLC | Compact multi-use lancing device |
EP1734858B1 (en) | 2004-03-22 | 2014-07-09 | BodyMedia, Inc. | Non-invasive temperature monitoring device |
US6971274B2 (en) | 2004-04-02 | 2005-12-06 | Sierra Instruments, Inc. | Immersible thermal mass flow meter |
US20050222518A1 (en) | 2004-04-06 | 2005-10-06 | Genocell, Llc | Biopsy and injection catheters |
US20060009727A1 (en) | 2004-04-08 | 2006-01-12 | Chf Solutions Inc. | Method and apparatus for an extracorporeal control of blood glucose |
US9101302B2 (en) | 2004-05-03 | 2015-08-11 | Abbott Diabetes Care Inc. | Analyte test device |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
US20050245799A1 (en) | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
US9380975B2 (en) | 2004-05-07 | 2016-07-05 | Becton, Dickinson And Company | Contact activated lancet device |
US7727147B1 (en) | 2004-05-14 | 2010-06-01 | Flint Hills Scientific Llc | Method and system for implantable glucose monitoring and control of a glycemic state of a subject |
CA3090413C (en) | 2004-06-04 | 2023-10-10 | Abbott Diabetes Care Inc. | Glucose monitoring and graphical representations in a data management system |
US7289855B2 (en) | 2004-06-09 | 2007-10-30 | Medtronic, Inc. | Implantable medical device package antenna |
US7299081B2 (en) | 2004-06-15 | 2007-11-20 | Abbott Laboratories | Analyte test device |
US7585287B2 (en) | 2004-06-16 | 2009-09-08 | Smiths Medical Md, Inc. | Device and method for insertion of a cannula of an infusion device |
DK1765288T3 (en) | 2004-06-18 | 2013-02-11 | Novartis Ag | Tobramycin preparations for the treatment of endobronchial infections |
IL162761A (en) | 2004-06-28 | 2013-04-30 | Avraham Shekalim | Device for continuous measurement of glucose in body fluids |
US20060001538A1 (en) | 2004-06-30 | 2006-01-05 | Ulrich Kraft | Methods of monitoring the concentration of an analyte |
US8343074B2 (en) | 2004-06-30 | 2013-01-01 | Lifescan Scotland Limited | Fluid handling devices |
US20060015020A1 (en) | 2004-07-06 | 2006-01-19 | Dexcom, Inc. | Systems and methods for manufacture of an analyte-measuring device including a membrane system |
US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
US7905833B2 (en) | 2004-07-13 | 2011-03-15 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP3718479B1 (en) | 2004-07-13 | 2021-12-15 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
US7640048B2 (en) | 2004-07-13 | 2009-12-29 | Dexcom, Inc. | Analyte sensor |
US20080242961A1 (en) | 2004-07-13 | 2008-10-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
JP2006028398A (en) | 2004-07-20 | 2006-02-02 | Nichias Corp | Sheet gasket and method for producing the same |
EP1781164A1 (en) | 2004-08-10 | 2007-05-09 | Novo Nordisk A/S | A method of forming a sterilised sensor package and a sterilised sensor package |
US20090048499A1 (en) | 2004-10-18 | 2009-02-19 | Novo Nordisk A/S | Sensor film for transcutaneous insertion and a method for making the sensor film |
CA2791286C (en) | 2004-11-22 | 2015-09-01 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
EP1824536B1 (en) | 2004-12-06 | 2009-08-26 | Novo Nordisk A/S | Ventilated skin mountable device |
DE102004059491B4 (en) | 2004-12-10 | 2008-11-06 | Roche Diagnostics Gmbh | Lancet device for creating a puncture wound and lancet drive assembly |
US9636450B2 (en) | 2007-02-19 | 2017-05-02 | Udo Hoss | Pump system modular components for delivering medication and analyte sensing at seperate insertion sites |
US8512243B2 (en) * | 2005-09-30 | 2013-08-20 | Abbott Diabetes Care Inc. | Integrated introducer and transmitter assembly and methods of use |
US9351669B2 (en) | 2009-09-30 | 2016-05-31 | Abbott Diabetes Care Inc. | Interconnect for on-body analyte monitoring device |
US9788771B2 (en) | 2006-10-23 | 2017-10-17 | Abbott Diabetes Care Inc. | Variable speed sensor insertion devices and methods of use |
US8333714B2 (en) | 2006-09-10 | 2012-12-18 | Abbott Diabetes Care Inc. | Method and system for providing an integrated analyte sensor insertion device and data processing unit |
US20090082693A1 (en) | 2004-12-29 | 2009-03-26 | Therasense, Inc. | Method and apparatus for providing temperature sensor module in a data communication system |
US20090105569A1 (en) | 2006-04-28 | 2009-04-23 | Abbott Diabetes Care, Inc. | Introducer Assembly and Methods of Use |
US7731657B2 (en) | 2005-08-30 | 2010-06-08 | Abbott Diabetes Care Inc. | Analyte sensor introducer and methods of use |
US9572534B2 (en) | 2010-06-29 | 2017-02-21 | Abbott Diabetes Care Inc. | Devices, systems and methods for on-skin or on-body mounting of medical devices |
US7697967B2 (en) | 2005-12-28 | 2010-04-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
US20110190603A1 (en) | 2009-09-29 | 2011-08-04 | Stafford Gary A | Sensor Inserter Having Introducer |
US8029441B2 (en) | 2006-02-28 | 2011-10-04 | Abbott Diabetes Care Inc. | Analyte sensor transmitter unit configuration for a data monitoring and management system |
US8613703B2 (en) | 2007-05-31 | 2013-12-24 | Abbott Diabetes Care Inc. | Insertion devices and methods |
US9398882B2 (en) | 2005-09-30 | 2016-07-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor and data processing device |
US20070027381A1 (en) | 2005-07-29 | 2007-02-01 | Therasense, Inc. | Inserter and methods of use |
US8571624B2 (en) | 2004-12-29 | 2013-10-29 | Abbott Diabetes Care Inc. | Method and apparatus for mounting a data transmission device in a communication system |
US9259175B2 (en) | 2006-10-23 | 2016-02-16 | Abbott Diabetes Care, Inc. | Flexible patch for fluid delivery and monitoring body analytes |
US7883464B2 (en) | 2005-09-30 | 2011-02-08 | Abbott Diabetes Care Inc. | Integrated transmitter unit and sensor introducer mechanism and methods of use |
US7470237B2 (en) | 2005-01-10 | 2008-12-30 | Ethicon Endo-Surgery, Inc. | Biopsy instrument with improved needle penetration |
US20060166629A1 (en) | 2005-01-24 | 2006-07-27 | Therasense, Inc. | Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems |
WO2006077262A1 (en) | 2005-01-24 | 2006-07-27 | Novo Nordisk A/S | Medical device with protected transcutaneous device |
US7499002B2 (en) | 2005-02-08 | 2009-03-03 | International Business Machines Corporation | Retractable string interface for stationary and portable devices |
US7545272B2 (en) | 2005-02-08 | 2009-06-09 | Therasense, Inc. | RF tag on test strips, test strip vials and boxes |
US20060181695A1 (en) | 2005-02-11 | 2006-08-17 | Sage Burton H Jr | Compensating liquid delivery system and method |
KR100638727B1 (en) | 2005-02-28 | 2006-10-30 | 삼성전기주식회사 | Concurrent transceiver for zigbee and bluetooth |
US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
US20090076360A1 (en) | 2007-09-13 | 2009-03-19 | Dexcom, Inc. | Transcutaneous analyte sensor |
PL2425776T3 (en) | 2005-04-07 | 2013-12-31 | Becton Dickinson Co | Lancet device |
WO2006110193A2 (en) | 2005-04-08 | 2006-10-19 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
US8298172B2 (en) | 2005-04-13 | 2012-10-30 | Novo Nordisk A/S | Medical skin mountable device and system |
US8060174B2 (en) | 2005-04-15 | 2011-11-15 | Dexcom, Inc. | Analyte sensing biointerface |
US8112240B2 (en) | 2005-04-29 | 2012-02-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing leak detection in data monitoring and management systems |
US7569050B2 (en) | 2005-05-06 | 2009-08-04 | Medtronic Minimed, Inc. | Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion |
US7905868B2 (en) | 2006-08-23 | 2011-03-15 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
WO2006133305A2 (en) | 2005-06-08 | 2006-12-14 | Sensors For Medicine And Science, Inc. | Insertion device and method |
EP2260759B1 (en) | 2005-06-17 | 2015-05-06 | F. Hoffmann-La Roche AG | Sensor system, arrangement and method for monitoring a compound, in particular glucose in body tissue. |
EP1896839A2 (en) | 2005-06-30 | 2008-03-12 | MC3, Inc. | Analyte sensors and compositions for use therein |
DE602005023458D1 (en) | 2005-09-12 | 2010-10-21 | Unomedical As | A delivery system for an infusion set having first and second spring units |
US8298389B2 (en) | 2005-09-12 | 2012-10-30 | Abbott Diabetes Care Inc. | In vitro analyte sensor, and methods |
DE502005009907D1 (en) | 2005-09-15 | 2010-08-26 | Roche Diagnostics Gmbh | Insertion head with handle |
US9072476B2 (en) | 2005-09-23 | 2015-07-07 | Medtronic Minimed, Inc. | Flexible sensor apparatus |
US7846311B2 (en) | 2005-09-27 | 2010-12-07 | Abbott Diabetes Care Inc. | In vitro analyte sensor and methods of use |
US7761165B1 (en) | 2005-09-29 | 2010-07-20 | Boston Scientific Neuromodulation Corporation | Implantable stimulator with integrated plastic housing/metal contacts and manufacture and use |
US9521968B2 (en) | 2005-09-30 | 2016-12-20 | Abbott Diabetes Care Inc. | Analyte sensor retention mechanism and methods of use |
US7550053B2 (en) | 2006-01-26 | 2009-06-23 | Ilh, Llc | Catheters with lubricious linings and methods for making and using them |
US20070095661A1 (en) | 2005-10-31 | 2007-05-03 | Yi Wang | Method of making, and, analyte sensor |
US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
US8182444B2 (en) | 2005-11-04 | 2012-05-22 | Medrad, Inc. | Delivery of agents such as cells to tissue |
ATE439155T1 (en) | 2005-11-08 | 2009-08-15 | M2 Medical As | INFUSION PUMP SYSTEM |
US20070173706A1 (en) | 2005-11-11 | 2007-07-26 | Isense Corporation | Method and apparatus for insertion of a sensor |
US7918975B2 (en) | 2005-11-17 | 2011-04-05 | Abbott Diabetes Care Inc. | Analytical sensors for biological fluid |
US7922971B2 (en) | 2005-11-30 | 2011-04-12 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
US8815175B2 (en) | 2005-11-30 | 2014-08-26 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
EP1961381A4 (en) | 2005-12-01 | 2011-04-13 | Arkray Inc | Sensor/lancet integrated device and method of collecting body fluid using the same |
EP1968432A4 (en) | 2005-12-28 | 2009-10-21 | Abbott Diabetes Care Inc | Medical device insertion |
US8515518B2 (en) | 2005-12-28 | 2013-08-20 | Abbott Diabetes Care Inc. | Analyte monitoring |
US8195267B2 (en) | 2006-01-26 | 2012-06-05 | Seymour John P | Microelectrode with laterally extending platform for reduction of tissue encapsulation |
US7736310B2 (en) | 2006-01-30 | 2010-06-15 | Abbott Diabetes Care Inc. | On-body medical device securement |
CA2926975C (en) | 2006-02-09 | 2019-10-29 | Deka Products Limited Partnership | Peripheral systems |
EP3756537B1 (en) | 2006-02-22 | 2023-08-02 | DexCom, Inc. | Analyte sensor |
US7826879B2 (en) | 2006-02-28 | 2010-11-02 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US7811430B2 (en) | 2006-02-28 | 2010-10-12 | Abbott Diabetes Care Inc. | Biosensors and methods of making |
EP1991110B1 (en) | 2006-03-09 | 2018-11-07 | DexCom, Inc. | Systems and methods for processing analyte sensor data |
US7887682B2 (en) | 2006-03-29 | 2011-02-15 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US20070233013A1 (en) | 2006-03-31 | 2007-10-04 | Schoenberg Stephen J | Covers for tissue engaging members |
US7653425B2 (en) | 2006-08-09 | 2010-01-26 | Abbott Diabetes Care Inc. | Method and system for providing calibration of an analyte sensor in an analyte monitoring system |
US7801582B2 (en) | 2006-03-31 | 2010-09-21 | Abbott Diabetes Care Inc. | Analyte monitoring and management system and methods therefor |
US7559899B2 (en) | 2006-04-12 | 2009-07-14 | Salutron, Inc. | Power saving techniques for continuous heart rate monitoring |
DK1857129T3 (en) | 2006-05-19 | 2009-06-29 | Hoffmann La Roche | Adapter device for attaching a medical instrument to the skin surface |
WO2007140783A2 (en) | 2006-06-07 | 2007-12-13 | Unomedical A/S | Inserter for transcutaneous sensor |
US20080071157A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
US7955348B2 (en) | 2006-06-15 | 2011-06-07 | Abbott Diabetes Care Inc. | Lancing devices and methods |
US7866026B1 (en) | 2006-08-01 | 2011-01-11 | Abbott Diabetes Care Inc. | Method for making calibration-adjusted sensors |
CA2659077A1 (en) | 2006-08-02 | 2008-02-07 | Unomedical A/S | Insertion device |
US7455663B2 (en) | 2006-08-23 | 2008-11-25 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
US8234706B2 (en) | 2006-09-08 | 2012-07-31 | Microsoft Corporation | Enabling access to aggregated software security information |
US8447376B2 (en) | 2006-10-04 | 2013-05-21 | Dexcom, Inc. | Analyte sensor |
US8478377B2 (en) | 2006-10-04 | 2013-07-02 | Dexcom, Inc. | Analyte sensor |
US8449464B2 (en) | 2006-10-04 | 2013-05-28 | Dexcom, Inc. | Analyte sensor |
US8562528B2 (en) | 2006-10-04 | 2013-10-22 | Dexcom, Inc. | Analyte sensor |
US8275438B2 (en) | 2006-10-04 | 2012-09-25 | Dexcom, Inc. | Analyte sensor |
US7831287B2 (en) | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8298142B2 (en) | 2006-10-04 | 2012-10-30 | Dexcom, Inc. | Analyte sensor |
US7822557B2 (en) | 2006-10-31 | 2010-10-26 | Abbott Diabetes Care Inc. | Analyte sensors and methods |
US8158081B2 (en) | 2006-10-31 | 2012-04-17 | Abbott Diabetes Care Inc. | Analyte monitoring devices |
DK2099384T3 (en) | 2006-11-28 | 2018-10-08 | Hoffmann La Roche | IMPLEMENTATION DEVICE AND PROCEDURE FOR INTRODUCING A SUBCUTANT IMPORTANT ELEMENT IN A BODY |
US7802467B2 (en) | 2006-12-22 | 2010-09-28 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
WO2008115409A1 (en) | 2007-03-19 | 2008-09-25 | Bayer Healthcare Llc | Continuous analyte monitoring assembly and method of forming the same |
BRPI0810520A2 (en) | 2007-04-27 | 2014-10-21 | Abbott Diabetes Care Inc | TESTING IDENTIFICATION USING CONDUCTIVE MODELS |
US20080269673A1 (en) | 2007-04-27 | 2008-10-30 | Animas Corporation | Cellular-Enabled Medical Monitoring and Infusion System |
JP5277242B2 (en) | 2007-04-30 | 2013-08-28 | メドトロニック ミニメド インコーポレイテッド | Needle insertion and fluid flow connections for infusion medium delivery systems |
WO2008136845A2 (en) | 2007-04-30 | 2008-11-13 | Medtronic Minimed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
DE102007026083A1 (en) | 2007-05-25 | 2008-11-27 | Haselmeier S.A.R.L. | injection device |
EP2152350A4 (en) | 2007-06-08 | 2013-03-27 | Dexcom Inc | Integrated medicament delivery device for use with continuous analyte sensor |
US20080319327A1 (en) | 2007-06-25 | 2008-12-25 | Triage Wireless, Inc. | Body-worn sensor featuring a low-power processor and multi-sensor array for measuring blood pressure |
US8002752B2 (en) | 2007-06-25 | 2011-08-23 | Medingo, Ltd. | Protector apparatus |
US8641618B2 (en) | 2007-06-27 | 2014-02-04 | Abbott Diabetes Care Inc. | Method and structure for securing a monitoring device element |
CA2694952A1 (en) | 2007-07-18 | 2009-01-22 | Unomedical A/S | Insertion device with pivoting action |
US8303545B2 (en) | 2007-09-07 | 2012-11-06 | Stat Medical Devices, Inc. | Infusion device and method of using and making the same |
WO2009039013A1 (en) | 2007-09-17 | 2009-03-26 | Icu Medical, Inc. | Insertion devices for infusion devices |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
EP2060284A1 (en) | 2007-11-13 | 2009-05-20 | F.Hoffmann-La Roche Ag | Medical injection device having data input means and a pivotable display |
US9839395B2 (en) | 2007-12-17 | 2017-12-12 | Dexcom, Inc. | Systems and methods for processing sensor data |
WO2009097450A1 (en) | 2008-01-30 | 2009-08-06 | Dexcom. Inc. | Continuous cardiac marker sensor system |
CA2711772A1 (en) | 2008-02-08 | 2009-08-13 | Unomedical A/S | Inserter assembly |
US20110046456A1 (en) | 2008-02-08 | 2011-02-24 | Hoerdum Elo Lau | Assembly Comprising Inserter, Cannula Part and Base Part |
EP2244761A2 (en) | 2008-02-20 | 2010-11-03 | Dexcom, Inc. | Continous medicament sensor system for in vivo use |
WO2009105709A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
US8122783B2 (en) | 2008-02-22 | 2012-02-28 | Sauer-Danfoss Inc. | Joystick and method of manufacturing the same |
US20090242399A1 (en) | 2008-03-25 | 2009-10-01 | Dexcom, Inc. | Analyte sensor |
US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US20090247855A1 (en) | 2008-03-28 | 2009-10-01 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
WO2009124095A1 (en) | 2008-03-31 | 2009-10-08 | Abbott Diabetes Care Inc. | Shallow implantable analyte sensor with rapid physiological response |
US9924898B2 (en) | 2008-04-15 | 2018-03-27 | Becton, Dickinson And Company | Flash activated passive shielding needle assembly |
US20090294277A1 (en) | 2008-05-30 | 2009-12-03 | Abbott Diabetes Care, Inc. | Method and system for producing thin film biosensors |
WO2010003886A1 (en) | 2008-07-07 | 2010-01-14 | Unomedical A/S | Inserter for transcutaneous device |
WO2010033724A2 (en) | 2008-09-19 | 2010-03-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
US20100331644A1 (en) | 2008-11-07 | 2010-12-30 | Dexcom, Inc. | Housing for an intravascular sensor |
US20100198034A1 (en) | 2009-02-03 | 2010-08-05 | Abbott Diabetes Care Inc. | Compact On-Body Physiological Monitoring Devices and Methods Thereof |
CN102308278A (en) | 2009-02-04 | 2012-01-04 | 雅培糖尿病护理公司 | Multi-function analyte test device and methods therefor |
US20100198033A1 (en) | 2009-02-05 | 2010-08-05 | Peter Krulevitch | Flexible indwelling biosensor, flexible indwelling biosensor insertion device, and related methods |
US20100213057A1 (en) | 2009-02-26 | 2010-08-26 | Benjamin Feldman | Self-Powered Analyte Sensor |
EP2410910A4 (en) | 2009-03-27 | 2014-10-15 | Dexcom Inc | Methods and systems for promoting glucose management |
EP2272553A1 (en) | 2009-06-29 | 2011-01-12 | Unomedical A/S | Inserter Assembly |
EP2424435B1 (en) | 2009-04-30 | 2021-06-02 | Dexcom, Inc. | Performance reports associated with continuous sensor data from multiple analysis time periods |
US9579456B2 (en) | 2009-05-22 | 2017-02-28 | Abbott Diabetes Care Inc. | Methods for reducing false hypoglycemia alarm occurrence |
WO2010141922A1 (en) | 2009-06-04 | 2010-12-09 | Abbott Diabetes Care Inc. | Method and system for updating a medical device |
US20100331643A1 (en) | 2009-06-30 | 2010-12-30 | Abbott Diabetes Care Inc. | Extruded Analyte Sensors and Methods of Using Same |
US8613892B2 (en) | 2009-06-30 | 2013-12-24 | Abbott Diabetes Care Inc. | Analyte meter with a moveable head and methods of using the same |
US10376213B2 (en) | 2009-06-30 | 2019-08-13 | Waveform Technologies, Inc. | System, method and apparatus for sensor insertion |
US20110027458A1 (en) | 2009-07-02 | 2011-02-03 | Dexcom, Inc. | Continuous analyte sensors and methods of making same |
CN104799866A (en) | 2009-07-23 | 2015-07-29 | 雅培糖尿病护理公司 | Analyte monitoring device |
CN102548598B (en) | 2009-08-07 | 2014-09-17 | 犹诺医药有限公司 | Delivery device with sensor and one or more cannulas |
WO2011025999A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Diabetes Care Inc. | Analyte sensor |
CN105686807B (en) | 2009-08-31 | 2019-11-15 | 雅培糖尿病护理公司 | Medical Devices |
WO2011026149A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Diabetes Care Inc. | Mounting unit having a sensor and associated circuitry |
WO2011026150A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Diabetes Care Inc. | Flexible mounting unit and cover for a medical device |
WO2011026130A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Diabetes Care Inc. | Inserter device including rotor subassembly |
US8882710B2 (en) | 2009-09-02 | 2014-11-11 | Medtronic Minimed, Inc. | Insertion device systems and methods |
WO2011038080A2 (en) * | 2009-09-25 | 2011-03-31 | Pharmaseq, Inc. | Apparatus and method to deliver a microchip |
CN102724913A (en) | 2009-09-30 | 2012-10-10 | 德克斯康公司 | Transcutaneous analyte sensor |
US20110082484A1 (en) | 2009-10-07 | 2011-04-07 | Heber Saravia | Sensor inserter assembly having rotatable trigger |
US20110184258A1 (en) | 2010-01-28 | 2011-07-28 | Abbott Diabetes Care Inc. | Balloon Catheter Analyte Measurement Sensors and Methods for Using the Same |
US9041730B2 (en) | 2010-02-12 | 2015-05-26 | Dexcom, Inc. | Receivers for analyzing and displaying sensor data |
GB201003581D0 (en) | 2010-03-04 | 2010-04-21 | Bacon Raymond J | Medicament dispenser |
EP4066731A1 (en) | 2010-03-24 | 2022-10-05 | Abbott Diabetes Care, Inc. | Medical device inserters |
EP2555670B1 (en) | 2010-04-05 | 2021-11-10 | KAZ Europe SA | Medical probe with insertion detector and corresponding method |
EP2557987B1 (en) | 2010-04-16 | 2018-09-19 | Abbott Diabetes Care, Inc. | Analyte monitoring device and methods |
US9336353B2 (en) | 2010-06-25 | 2016-05-10 | Dexcom, Inc. | Systems and methods for communicating sensor data between communication devices of a glucose monitoring system |
US20110319738A1 (en) | 2010-06-29 | 2011-12-29 | Abbott Diabetes Care Inc. | Medical Devices and Insertion Systems and Methods |
WO2012050926A2 (en) | 2010-09-29 | 2012-04-19 | Dexcom, Inc. | Advanced continuous analyte monitoring system |
EP2436311A1 (en) * | 2010-10-04 | 2012-04-04 | PharmaSens AG | Diagnostic device |
WO2012058337A2 (en) | 2010-10-27 | 2012-05-03 | Dexcom, Inc. | Continuous analyte monitor data recording device operable in a blinded mode |
-
2013
- 2013-09-28 US US14/040,674 patent/US10226207B2/en active Active
-
2017
- 2017-03-29 US US15/473,560 patent/US20170202488A1/en not_active Abandoned
-
2019
- 2019-01-31 US US16/263,155 patent/US11160475B2/en active Active
-
2021
- 2021-10-29 US US17/514,193 patent/US20220125346A1/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2623785A (en) * | 2022-10-26 | 2024-05-01 | Glucorx Tech Limited | Epidermal support patch |
Also Published As
Publication number | Publication date |
---|---|
US20190365297A1 (en) | 2019-12-05 |
US11160475B2 (en) | 2021-11-02 |
US20140031655A1 (en) | 2014-01-30 |
US20170202488A1 (en) | 2017-07-20 |
US10226207B2 (en) | 2019-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220125346A1 (en) | Sensor inserter having introducer | |
US20110190603A1 (en) | Sensor Inserter Having Introducer | |
US11013440B2 (en) | Medical device inserters and processes of inserting and using medical devices | |
US11213229B2 (en) | Analyte sensor and apparatus for insertion of the sensor | |
US20220183594A1 (en) | Sensor insertion devices and methods of use | |
US20120303043A1 (en) | Medical Device Inserters and Processes of Inserting and Using Medical Devices | |
AU2011230596A1 (en) | Medical device inserters and processes of inserting and using medical devices |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
AS | Assignment |
Owner name: ABBOTT DIABETES CARE INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:STAFFORD, GARY ASHLEY;REEL/FRAME:058895/0341 Effective date: 20220121 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NOTICE OF ALLOWANCE MAILED -- APPLICATION RECEIVED IN OFFICE OF PUBLICATIONS |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |