US20140052100A1 - Injection needle assembly and medicine injection device - Google Patents

Injection needle assembly and medicine injection device Download PDF

Info

Publication number
US20140052100A1
US20140052100A1 US14/065,203 US201314065203A US2014052100A1 US 20140052100 A1 US20140052100 A1 US 20140052100A1 US 201314065203 A US201314065203 A US 201314065203A US 2014052100 A1 US2014052100 A1 US 2014052100A1
Authority
US
United States
Prior art keywords
needle
skin
needle tube
medicine
disposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/065,203
Other languages
English (en)
Inventor
Yoichiro Iwase
Junichi Ogawa
Kouichi Tachikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of US20140052100A1 publication Critical patent/US20140052100A1/en
Assigned to TERUMO KABUSHIKI KAISHA reassignment TERUMO KABUSHIKI KAISHA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TACHIKAWA, KOUICHI, IWASE, YOICHIRO, OGAWA, JUNICHI
Priority to US15/730,503 priority Critical patent/US10398851B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A61M5/345—Adaptors positioned between needle hub and syringe nozzle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0222—Materials for reducing friction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/349—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using adhesive bond or glues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Definitions

  • the present invention relates to an injection needle assembly and a medicine injection device, which have a skin contact portion that is disposed to cover the area surrounding a needle tube and which makes contact with and/or faces the skin.
  • an injection needle assembly is provided with a skin contact portion that allows adjustment of the depth of a needle puncturing in order to stably puncture the skin.
  • a skin contact portion that allows adjustment of the depth of a needle puncturing in order to stably puncture the skin.
  • Such a configuration makes it possible to reliably penetrate the injection needle to a target depth. Further, such capability of stable puncturing enables stable administration of a medicine into the skin, as described in Japanese Patent Application National Publication No. 2005-527249.
  • An injection needle assembly is connected to a syringe that is to be filled with a medicine, and thus a medicine injection device is assembled.
  • Air must be exhausted from the syringe, however, before introducing a medicine into it.
  • a user of the medicine injection device must first perform a procedure to exhaust the air from the syringe, and then introduce the medicine into the device. This procedure or step is referred to as removal of air (“air removal” hereinafter) in which the air contained in the syringe is exhausted.
  • a cylindrical skin contact portion is connected to a needle hub.
  • the skin contact portion is disposed to cover a needle tube, but allows a space between the needle tube and the skin contact portion.
  • the disclosure herein provides an injection needle assembly and a medicine injection device which prevent the medicine that has been spilled during air removal and which is held in a skin contact portion from attaching to the skin of a user.
  • an exemplary embodiment of an injection needle assembly includes: a needle tube having a needle tip for puncturing the skin; a needle hub; and an absorption part for absorbing a medicine.
  • the needle hub includes: a retention part for retaining the needle tube; an insertion part into which an output portion of a syringe is inserted; and a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and which makes contact with and/or faces the skin when a living body is punctured with the needle tube.
  • the absorption part is disposed in the skin contact portion of the needle hub.
  • a medicine injection device includes: a syringe having an output portion; a needle tube having a needle tip for puncturing the skin; a needle hub; and an absorption part for absorbing a medicine.
  • the needle hub includes: a retention part for retaining the needle tube; an insertion part into which the output portion of the syringe is inserted; and a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and which makes contact with and/or faces the skin when a living body is punctured with the needle tube.
  • the absorption part is disposed in the skin contact portion of the needle hub.
  • the absorption part disposed in the skin contact portion of the needle hub is capable of absorbing the medicine that has been spilled during the air removal procedure and is held in the skin contact portion. As a result, it is possible to prevent the medicine that has been spilled during the air removal step from contacting or attaching to a user.
  • FIG. 1 is a side elevational view showing a first exemplary embodiment of a medicine injection device according to the disclosure herein.
  • FIG. 2 is an exploded view showing the first exemplary embodiment of the medicine injection device according to the disclosure herein.
  • FIG. 3 is a cross-sectional view showing the first exemplary embodiment of the medicine injection device according to the disclosure herein.
  • FIG. 4 is a cross-sectional view showing a second embodiment of the medicine injection device according to the disclosure herein.
  • FIGS. 5A and 5B are cross-sectional views showing a process of a medicine being absorbed in the second embodiment of the medicine injection device according to the disclosure herein, with FIG. 5A being a cross-sectional view showing a state where the medicine spills and stays in a skin contact portion, and FIG. 5B being a cross-sectional view showing a state where the medicine that had spilled into the skin contact portion has been absorbed into an absorption channel.
  • FIGS. 1 through 5 Exemplary embodiments of an injection needle assembly and a medicine injection device according to the disclosure herein are described below with reference to FIGS. 1 through 5 . It is noted that the same reference numerals are attached to common components in the accompanying figures. It is further noted that the disclosure is in no way restrained by the following exemplary embodiments.
  • FIG. 1 and FIG. 2 An injection needle assembly and a medicine injection device according to a first exemplary embodiment of the disclosure are described with reference to FIG. 1 and FIG. 2 .
  • a medicine injection device 1 is used for injecting a medicine into an upper skin layer by puncturing a skin surface with a needle tip.
  • the medicine injection device 1 includes an injection needle assembly 2 , and a syringe 3 to which the injection needle assembly 2 is detachably attached.
  • the skin includes three regions, that is, epidermis, dermis and subcutis.
  • the epidermis is a layer of 50 to 200 ⁇ m from the outermost skin surface, while the dermis is a layer of 1.5 to 3.5 mm continuing from and beneath the epidermis.
  • Influenza vaccines are generally administered with a subcutaneous or intramuscular injection, and therefore are injected to a lower layer of the skin or a deeper region thereof.
  • the upper skin layer here means the epidermis and dermis of the skin.
  • the injection needle assembly 2 includes: a hollow needle tube 5 having a needle hole; a needle hub 6 to which the needle tube 5 is fixed; and an elastic member 7 disposed inside of the needle hub 6 .
  • the needle hub 6 includes: a first member 11 that is a retention part for retaining the needle tube 5 ; and a second member 12 that is a connector part to which the syringe 3 is connected.
  • the needle tube 5 of the injection needle assembly 2 preferably includes a needle tube of the size of 22 to 33-gauge (i.e., an outer diameter of 0.2 to 0.7 mm), compliant to the ISO standard for a needle tube for medicine (Ref: ISO 9626: 1991/Amd. 1: 2001 (E)).
  • a 26 to 33-gauge, or preferably a 30 to 33-gauge, can of course also be used for injecting into an upper skin layer.
  • a length of the needle tube 5 on the blade surface 5 a in the axial direction (noted as “bevel length B” hereinafter) may be 1.4 mm or less, which is equivalent to the smallest thickness of an upper skin layer (for adults), and may be 0.5 mm or more, which is a bevel length in a case where a short bevel is formed on a 33-gauge needle tube. That is, the bevel length B is preferably set in a range of 0.5-1.4 mm.
  • the bevel length B is more preferably set in a range of 0.5-0.9 mm, considering that the minimum thickness of the upper skin layer may be 0.9 mm or less (for infants).
  • the short bevel represents a blade surface inclined by an angle of 18 to 25 degrees relative to the longitudinal direction of a needle that is commonly used for an injecting needle.
  • the surface of the needle tip 5 A of the needle tube 5 is preferably coated with a coating agent made of, for example, a silicon resin, a fluorine series resin or the like. This configuration makes it possible to reduce friction between the skin and needle tube 5 when a living body is punctured with the needle tube, thus enabling reduction in the pain associated with the puncture.
  • a preferred material for the needle tube 5 may be, for example, stainless steel. Aluminum, aluminum alloy, titanium, titanium alloy or other material may also be used.
  • the needle tube 5 may be a straight needle, or a taper needle that has a taper structure for at least a part of the needle may also be used. With respect to a taper needle, there is a possible configuration that has a larger diameter at a base portion compared to that at the needle tip portion, with the middle part having a taper configuration.
  • the needle tube 5 may have a cross-sectional form of not only a circle, but also a polygon such as, for example, a triangle.
  • the needle tube 5 is fixed to the needle hub 6 .
  • the first member 11 and second member 12 of the needle hub 6 are preferably formed as separate members. However, they may be formed as an integrated member.
  • the first member 11 and second member 12 may be made of a synthetic resin such as, for example, polycarbonate, polypropylene, or polyethylene.
  • the first member 11 is provided with a skin contact portion 25 that makes contact with and/or faces the skin.
  • the skin contact portion 25 is disposed in a manner so as to cover the area surrounding the needle tube 5 when the needle tube 5 is attached to the first member 11 .
  • the skin contact portion 25 includes a substantially columnar base part 15 , an adjustment portion 16 , a stabilizer 17 , and a guide portion 18 .
  • the base part 15 has end faces 15 a and 15 b that are orthogonal to the axial direction.
  • the adjustment portion 16 is disposed at a center portion of the end face 15 a on one end of the base part 15 in the axial direction and includes a columnar convex portion protruding in the axial direction of the base part 15 .
  • the center shaft of the adjustment portion 16 coincides with that of the base part 15 .
  • the center shaft of the base part 15 and adjustment portion 16 is provided with a through hole 21 through which the needle tube 5 extends.
  • the base part 15 is provided with an introduction hole 22 (see FIG. 2 ) for introducing an adhesive 20 (see FIG. 3 ) into the through hole 21 .
  • the introduction hole 22 is open into an outer peripheral surface of the base part 15 and communicates with the through hole 21 in a manner substantially orthogonal thereto. That is, the needle tube 5 is adhesively fixed to the base part 15 by the adhesive 20 introduced into the through hole 21 from the introduction hole 22 .
  • the base end 5 B side of the needle tube 5 protrudes from the end face 15 b that is the other end of the base part 15 in the axial direction.
  • the base part 15 is inserted into the second member 12 from the end face 15 b side, while the base end 5 B side of the needle tube 5 is inserted into a through hole 45 (described later) of the elastic member 7 .
  • the end face 15 b of the base part 15 thus abuts an end face 41 a of the elastic member 7 .
  • a connecting flange 24 is provided on the outer circumferential surface of the base part 15 .
  • the connecting flange 24 is formed as a ring-like flange protruding outwardly in the radial direction from the base part 15 and has flat surfaces 24 a and 24 b that are opposite to each other in the axial direction of the base part 15 .
  • the second member 12 is connected to the flat surface 24 b of the connecting flange 24 .
  • An edge portion of the connecting flange 24 also constitutes a guide portion 18 , as described in detail below.
  • the end face of the adjustment portion 16 defines a needle protrusion surface 16 a from which the needle tip 5 A side of the needle tube 5 protrudes.
  • the needle protrusion surface 16 a is formed as a flat surface orthogonal to the axial direction of the needle tube 5 .
  • the needle protrusion surface 16 a contacts a skin surface and regulates the depth of puncture of the needle tube 5 when an upper skin layer is punctured with the needle tube 5 .
  • the depth of the puncture of the needle tube 5 into the upper skin layer is determined by the length of the needle tube 5 (noted as “protruding length L” hereinafter) protruding from the needle protrusion surface 16 a.
  • the thickness of an upper skin layer is equivalent to the depth from a skin surface to the dermis layer and falls approximately in a range of 0.5-3.0 mm. Therefore, the protruding length L of the needle tube 5 preferably can be set in a range of 0.5-3.0 mm.
  • a vaccine is generally administered in an upper arm region.
  • it is appropriate to administer in a shoulder region, particularly at the triangular muscle region, where the skin is generally thick.
  • the thickness of the upper skin layer of the triangular muscle has been individually measured on 19 infants and 31 adults.
  • the measurements have been made by using an ultrasonic measurement apparatus (NP60R-UBM; high definition imaging echo for small animals; Nepa Gene Co., Ltd) and imaging the upper skin layer where ultrasonic reflectivity is high.
  • Logarithmic normal distribution is constituted by the measurement values, and therefore a range of MEAN ⁇ 2SD has been calculated by a geometric mean method.
  • the thickness range of the upper skin layer of the triangular muscle for infants is determined to be between 0.9 and 1.6 mm.
  • the thickness ranges of the upper skin layer of the triangular muscle for adults determined to be: between 1.4 and 2.6 mm at the distal portion; between 1.4 and 2.5 mm at the central portion; and between 1.5 and 2.5 mm at the proximal portion.
  • the protruding length L makes it possible to securely position the blade surface 5 a of the needle tip 5 A in the upper skin layer.
  • This makes it possible to position the needle opening (i.e., medicine fluid output port) that opens into the blade surface 5 a at the upper skin layer, no matter where the needle opening is located within the blade surface 5 a.
  • the needle opening i.e., medicine fluid output port
  • the needle protrusion surface 16 a is formed so that the distance S from the circumferential edge thereof to the circumferential surface of the needle tube 5 will be 1.4 mm or less (more preferably in a range of 0.3-1.4 mm).
  • the distance S from the circumferential edge of the needle protrusion surface 16 a to the circumferential surface of the needle tube 5 is determined in consideration of the pressure exerted on a fluid bubble that is formed when administering a medicine to the upper skin layer. That is, the needle protrusion surface 16 a is set at a size that is sufficiently smaller than a bubble formed in the upper skin layer, and thus allows the forming of a bubble. As a result, it is possible to prevent the needle protrusion surface 16 a from pressing the skin surrounding the needle tube 5 and thereby prevent leaking of the administered medicine.
  • the stabilizer 17 is cylindrically formed to protrude from the flat surface 24 a of the connecting flange 24 disposed on the base part 15 .
  • the cylindrical opening of the stabilizer 17 is provided with the needle tube 5 and the adjustment portion 16 . That is, the stabilizer 17 forms a cylinder covering the area surrounding the adjustment portion 16 in which the needle tube 5 is inserted, and is disposed at a distance spaced from the needle tip 5 A of the needle tube 5 in the radial direction.
  • the end face 17 a of the stabilizer 17 is disposed at a position shifted toward the base end 5 B of the needle tube 5 relative to the needle protrusion surface 16 a of the adjustment portion 16 .
  • the needle protrusion surface 16 a makes contact with the skin surface first, and then, with the end face 17 a of the stabilizer 17 .
  • the end face 17 a of the stabilizer 17 contacting the skin stabilizes the orientation of the medicine injection device 1 , and thereby makes it possible to maintain the orientation of the needle tube 5 substantially orthogonal to the skin.
  • the end face 17 a of the stabilizer 17 would also make it possible to maintain the needle tube 5 at an orientation substantially orthogonal to the skin even if the end face 17 a was positioned at the same plane as the needle protrusion surface 16 a or if the end face 17 a was positioned at a position shifted toward the needle tip 5 A side of the needle tube 5 from the needle protrusion surface 16 a.
  • the distance between the end face 17 a of the stabilizer 17 and the needle protrusion surface 16 a in the axial direction thereof is preferably 1.3 mm or less in consideration of a bump on the skin caused by pressing the stabilizer 17 onto the skin.
  • the internal diameter d of the stabilizer 17 is set at a value equivalent to, or larger than, the diameter of a fluid bubble formed on the skin. Specifically, the diameter d is so set that the distance T from the inner wall surface of the stabilizer 17 to the circumferential edge of the needle protrusion surface 16 a falls in a range of 4 to 15 mm. This configuration makes it possible to assure formation of a bubble by preventing application of pressure from the inner wall surface of the stabilizer 17 to the bubbles.
  • the smallest distance T from the inner wall surface of the stabilizer 17 to the outer circumferential surface of the adjustment portion 16 may be discretionarily increased, provided that it is 4 mm or greater.
  • the distance T is preferably set at a maximum of 15 mm in consideration of the thinness of infants' arms.
  • the adjustment portion 16 will never invade the skin. Therefore, taking into consideration the distance T (4 mm or larger) from the inner wall surface of the stabilizer 17 to the circumferential edge of the needle protrusion surface 16 a and the diameter (about 0.3 mm) of the needle protrusion surface 16 a, the internal diameter d of the stabilizer 17 can preferably be 9 mm or larger.
  • the form of the stabilizer 17 is not limited to a circular cylindrical shape as illustrated; it may be formed to have a square cylindrical shape, such as a rectangular column or hexagonal column, with a cylindrical hole bored at the center.
  • the guide portion 18 is positioned on an outer side of the first member 11 , extending further in the radial direction than the stabilizer 17 of the connecting flange 24 .
  • the guide portion 18 has a contact surface 18 a that contacts the skin.
  • the contact surface 18 a is a part of the flat surface 24 a of the connecting flange 24 and is a flat surface substantially parallel to the end face 17 a of the stabilizer 17 . Pressing on the stabilizer 17 until the contact surface 18 a of the guide portion 18 contacts the skin makes it possible to apply a force at a predetermined value, the force with which the stabilizer 17 and the needle tube 5 press the skin. With this configuration, a part of the needle tube 5 protruding from the needle protrusion surface 16 a (equivalent to the protruding length L) is securely penetrated into the skin.
  • the distance Y (noted as “guide portion height” hereinafter) from the contact surface 18 a of the guide portion 18 to the end face 17 a of the stabilizer 17 is set at a length to allow the needle tube 5 and the stabilizer 17 to press the skin with the correct pressing force so as to puncture the skin.
  • the correct pressing force of the needle tube 5 and the stabilizer 17 is, for example, 3 to 20 N. This configuration enables a user to cause the guide portion 18 to control the pressing force exerted to the skin by the needle tube 5 and the stabilizer 17 , making it possible to securely position the needle tip 5 A (i.e., the blade surface 5 a ) of the needle tube 5 in the upper skin layer and provide the user with a feeling of ease.
  • the guide portion height Y is appropriately determined on the basis of the internal diameter d of the stabilizer 17 and the length X (noted as “guide portion length” hereinafter) from the edge surface of the guide portion 18 to the outer peripheral surface of the stabilizer 17 .
  • the guide portion height Y is set in a range of 2.3-6.6 mm.
  • the adjustment portion 16 and stabilizer 17 of the skin contact portion 25 form a concave portion 19 .
  • the concave portion 19 is provided with an absorption part 26 .
  • the absorption part 26 is formed by a moisture absorption material.
  • the medicine that has been spilled from the needle tube 5 during air removal spills onto the absorption part 26 of the skin contact portion 25 .
  • the medicine having thus dropped onto the absorption part 26 is absorbed by the absorption part 26 and retained therein. This configuration inhibits discharging of the medicine that has been spilled from the needle tube 5 and makes it possible to prevent attachment of the medicine to the user.
  • Non-woven fabric, absorbent polymer and the like may be used as a material for the moisture absorption material of the absorption part 26 .
  • the second member 12 is formed substantially cylindrical.
  • One end of the second member 12 in the axial direction constitutes an insertion portion 31 into which the base part 15 of the first member 11 is inserted, while the other end constitutes a coupling portion 32 configured to be coupled with an output portion 52 (described later) of the syringe 3 .
  • a cylindrical hole 31 a of the insertion portion 31 is set at a size corresponding to the base part 15 of the first member 11 .
  • the insertion portion 31 is provided with a fixing flange 34 that is configured for connecting to the connecting flange 24 of the first member 11 .
  • the fixing flange 34 is formed as a ring-like flange projecting in the radial direction continuously from the end of the insertion portion 31 .
  • the fixing flange 34 is abutted, and fixed, to the flat surface 24 b of the connecting flange 24 of the first member 11 .
  • a method of fixing the fixing flange 34 to the connecting flange 24 can include, for example, an adhesive, ultrasonic welding, laser welding, and fastening screws.
  • the cylindrical hole 32 a of the coupling portion 32 is set at a size corresponding to the output portion 52 of the syringe 3 , with the diameter of the cylindrical hole 32 a decreasing toward the insertion portion 31 side.
  • the coupling portion 32 is provided on its internal surface with a groove 35 formed for threadedly engaging the output portion 52 of the syringe 3 .
  • An engagement portion 37 is disposed between the insertion portion 31 and the coupling portion 32 .
  • the engagement portion 37 is configured to be engaged with the elastic member 7 .
  • the engagement portion 37 is formed as a step portion protruding inwardly in the radial direction from the inner surface of the second member 12 and has engagement surfaces 37 a and 37 b that are substantially orthogonal to the axial direction of the second member 12 .
  • the engagement surface 37 a of the engagement portion 37 engages a flange portion 42 (described later) of the elastic member 7
  • the engagement surface 37 b engages a stopper protrusion portion 43 of the elastic member 7 .
  • the elastic member 7 is disposed inside of the second member 12 of the needle hub 6 and is positioned between the first member 11 and the syringe 3 .
  • the elastic member 7 includes: a body part 41 ; a flange portion 42 provided on one end of the body part 41 in the axial direction; and a stopper protrusion portion 43 provided on the other end of the body part 41 .
  • the body part 41 is substantially columnar and has end faces 41 a and 41 b that are orthogonal to the axial direction.
  • the end face 41 a of the body part 41 abuts with the end face 15 b of the base part 15 of the first member 11 , while the end face 41 b abuts in a fluid-tight manner with a tip end of the output portion 52 provided on the syringe 3 . That is, the end face 41 b constitutes an abutting surface where the tip end of the output portion 52 is fluid-tightly abutted.
  • the body part 41 is provided with a through hole 45 for allowing insertion of the base end 5 B side of the needle tube 5 protruding from the end face 15 b of the base part 15 .
  • the through hole 45 extends in the axial direction of the body part 41 and opens into the end faces 41 a and 41 b.
  • the inner surface of the body part 41 includes an end face-side separation portion 46 , an abutment surface-side separation portion 47 , and a close contact portion 48 .
  • the end face-side separation portion 46 forms an opening of the through hole 45 on the end face 41 a.
  • the end face-side separation portion 46 is spaced from the outer circumferential surface of the needle tube 5 and has a tapered form in which the diameters of the through hole 45 continuously increase toward the end face 41 a. This configuration makes it possible to easily insert, into the through hole 45 , the base end 5 B side of the needle tube 5 protruding from the end face 15 b of the base part 15 . It is appreciated by one skilled in the art that the end face-side separation portion 46 of the through hole 45 may have an alternative form, provided that it allows easy insertion of the needle tube 5 into the through hole 45 .
  • the abutment surface-side separation portion 47 forms an opening of the through hole 45 on the end face 41 b.
  • the abutment surface-side separation portion 47 is separated or spaced from the outer circumferential surface of the needle tube 5 and has a tapered form in which the diameter of the through hole 45 continuously increase toward the end face 41 b.
  • the provision of the abutment surface-side separation portion 47 to the elastic member 7 makes it possible to prevent the end face 41 b side of the body part 41 from deforming and thereby covering the base end 5 B of the needle tube 5 and blocking the needle hole.
  • the abutment surface-side separation portion 47 of the through hole 45 is not limited to a tapered form.
  • it may be a concave portion that has a diameter larger than the diameter of the close contact portion 48 and is separated from the outer circumferential surface of the needle tube 5 .
  • the abutment surface-side separation portion 47 of the through hole 45 may have any form, provided that it is capable of preventing the body part 41 from deforming on the end face 41 b side, covering the base end 5 B of the needle tube 5 , and blocking the needle hole.
  • the close contact portion 48 is formed between the end face-side separation portion 46 and the abutment surface-side separation portion 47 .
  • the close contact portion 48 contacts the outer circumferential surface of the needle tube 5 in a fluid-tight manner. This configuration makes it possible to prevent invasion of the medicine inside of the syringe 3 into the first member 11 side of the needle hub 6 from a gap between the needle tube 5 and the elastic member 7 .
  • the flange portion 42 has a ring-like shape protruding in the radial direction from the outer circumferential surface of the body part 41 .
  • the outer diameter of the flange portion 42 is substantially the same as the outer diameter of the base part 15 of the first member 11 . Therefore, one flat surface of the flange portion 42 abuts the engagement surface 37 a of the engagement portion 37 disposed in the second member 12 , while the other flat surface abuts the end face 15 b of the base part 15 of the first member 11 .
  • the elastic member 7 is attached to the needle hub 6 by the engagement portion 37 of the second member 12 and the base part 15 of the first member 11 sandwiching the flange portion 42 .
  • the stopper protrusion portion 43 is formed in a ring-like shape protruding outwardly in the radial direction from the outer circumferential surface of the body part 41 , similar to the form of the flange portion 42 .
  • the stopper protrusion portion 43 is engaged with the engagement surface 37 b of the engagement portion 37 disposed on the second member 12 .
  • the elastic member 7 is thus locked from moving in an axial direction by the flange portion 42 and the stopper protrusion portion 43 engaging with the engagement portion 37 of the second member 12 .
  • various elastomeric materials such as natural rubber and silicone elastomer, various elastomeric materials such as urethane series and styrene series, or elastic materials made from a mixture of them may be used.
  • the syringe 3 includes a syringe body 51 , and an output portion 52 that continues to the syringe body 51 .
  • the syringe body 51 has a circular cylindrical body.
  • the output portion 52 protrudes from one end of the syringe body 51 in the axial direction and has a circular cylindrical body with a smaller diameter than that of the syringe body 51 .
  • the output portion 52 has a tapered form whose diameter continuously decreases toward the tip end.
  • An end face 52 a constituting the tip end of the output portion 52 is a flat surface orthogonal to the axial direction and fluid-tightly abuts to the end face 41 b of the elastic member 7 .
  • the outer circumferential surface of the output portion 52 is provided with a screw threaded portion 53 for threadably connecting with the second member 12 of the needle hub 6 .
  • the syringe body 51 internally houses a gasket (not shown in a drawing).
  • a space inside of the syringe body 51 is sectioned by the gasket so that one space communicating with the output portion 52 , together with the space inside of the output portion 52 , forms a fluid chamber 56 .
  • a plunger (not shown in a drawing) is disposed in the other space inside of the syringe body 51 .
  • the plunger is connected to the gasket and protrudes from an opening at the other end of the syringe body 51 .
  • An operation of the plunger moves the gasket in the axial direction inside of the syringe body 51 , performing suction of a medicine into the fluid chamber 56 and outputting of the medicine filled in the fluid chamber 56 .
  • a synthetic resin such as polycarbonate, polypropylene, and polyethylene, or a metallic material such as stainless steel and aluminum may be used for the material of the syringe body 51 and the output portion 52 .
  • a user exhausts the air contained inside of the syringe 3 of an assembled medicine injection device 1 , that is, the user performs what is referred to as “air removal”, the air removal procedure.
  • This operation causes a small amount of a medicine to be spilled from the needle tube 5 .
  • the spilled medicine drops into the concave portion 19 formed by the adjustment portion 16 and the stabilizer 17 of the skin contact portion 25 . Having dropped into the concave portion 19 , the medicine is then absorbed by the absorption part 26 formed in the concave portion 19 .
  • the end face 17 a of the stabilizer 17 is then placed adjacent to a skin in order to puncture a living body with the needle tip 5 A of the needle tube 5 .
  • This operation causes the needle tip 5 A of the needle tube 5 to face the skin to be punctured.
  • the medicine injection device 1 is moved substantially orthogonally to the skin, the skin is punctured with the needle tip 5 A, and simultaneously the end face 17 a of the stabilizer 17 is pressed against the skin. In this event, the needle protrusion surface 16 a contacts the skin to deform it flatly, making it possible to puncture the skin with the needle tip 5 A of the needle tube 5 for a depth equivalent to the protrusion length L.
  • the end face 17 a of the stabilizer 17 is pressed until the contact surface 18 a of the guide portion 18 makes contact with the skin.
  • the guide height Y is set so that the skin can be punctured with the needle tube 5 and the stabilizer 17 with an appropriate magnitude of pressing force. Therefore, the force pressing the skin is maintained at a predetermined value by the stabilizer 17 .
  • the configuration enables the user to recognize the appropriate pressing force for the stabilizer 17 and to securely position the needle tip 5 A and blade surface 5 a of the needle tube 5 in the upper skin layer.
  • the guide portion 18 functions as an indicator for the user to recognize the appropriate magnitude of pressing force of the stabilizer 17 , allowing him to comfortably use the medicine injection device 1 .
  • the stabilizer 17 abutting the skin also stabilizes the orientation of the medicine injection device 1 , enabling straight puncture of the skin with the needle tube 5 . It is also possible to prevent a wobbling of the needle tube 5 after the puncturing, thus enabling stable administration of the medicine.
  • a needle tube has, for example, an extremely short protrusion length such as about 0.5 mm.
  • the skin when pressed by the stabilizer 17 , is pushed down in the orthogonal direction, expanding the skin inside of the stabilizer 17 , and thereby generating tension in the skin. This state makes it difficult for the skin to escape from the needle tip 5 A of the needle tube 5 . Therefore, the provision of the stabilizer 17 also renders a benefit for easy puncturing of the skin with the needle tip 5 A.
  • the plunger (not shown in a drawing) is pressed to move the gasket (not shown in a drawing) to a side where the output portion 52 exists. Accordingly, the medicine filled in the fluid chamber 56 of the syringe 3 is pushed out from the output portion 52 , pushed through the needle hole of the needle tube 5 and injected into the upper skin layer from the needle tip 5 A. In this event, no space is formed between the tip end of the output portion 52 and the base end 5 B of the needle tube 5 , and therefore a residual amount of the medicine can be reduced.
  • an absorption part 26 disposed in the skin contact portion 25 is formed by the moisture absorption material according to the exemplary embodiment, the disclosure is not limited by the illustrated embodiment.
  • an absorption part may also be configured by fixing a member having a net-like structure to the concave portion 19 formed by the adjustment portion 16 and the stabilizer 17 .
  • the member having a net-like structure is set at a size corresponding to the size of the concave portion 19 formed by the adjustment portion 16 and the stabilizer 17 .
  • a synthetic resin such as polycarbonate, polypropylene, or polyethylene may be used as a material for the member having a net-like structure.
  • the absorption part 26 defined by the member having a net-like structure absorbs, by virtue of capillarity of the net-like structure, the medicine thereinto and retains therein, the medicine that has been spilled during air removal. This configuration thus makes it possible to prevent the medicine that has been spilled during air removal from attaching to the user.
  • the net-like structure may alternatively be configured by a large number of planar members arranged in parallel with a predetermined gap between one member and another. This configuration also makes it possible to absorb and retain the medicine that has been spilled during air removal in the channels that are formed between individual planar members.
  • the disclosure here is not limited by such embodiment.
  • a large number of channels may be integrally molded when molding the first member 11 .
  • a second exemplary embodiment of the medicine injection device according to the disclosure is described with reference also to FIG. 4 and FIGS. 5A and 5B .
  • An injection needle assembly 72 according to the second exemplary embodiment has a configuration similar to that of the injection needle assembly 2 of the first exemplary embodiment. Where the injection needle assembly 72 according the second exemplary embodiment differs from the injection needle assembly 2 of the first exemplary embodiment is only an absorption part 76 . Accordingly, the absorption part 76 is described here. Other components common to the injection needle assembly 2 are indicated with the same reference numerals, and no duplicate description is provided.
  • the injection needle assembly 72 includes: a needle tube 5 having a needle tip 5 A for puncturing the skin; a needle hub 6 ; and an absorption part 76 .
  • the needle hub 6 includes a first member 11 and a second member 12 .
  • the first member 11 is provided with a skin contact portion 25 for facing and/or making contact with the skin.
  • the skin contact portion 25 is disposed in a manner so as to cover an area surrounding the needle tube 5 when it is attached to the first member 11 .
  • the skin contact portion 25 includes a substantially circular columnar base part 15 , an adjustment portion 16 , a stabilizer 17 and a guide portion 18 .
  • An absorption part 76 is disposed in the skin contact portion 25 and the second member 12 .
  • the absorption part 76 includes a first absorption channel 76 a and a second absorption channel 76 b.
  • the first absorption channel 76 a is formed in a direction toward the elastic member 7 side, along the axial direction of the base part 15 that is the skin contact portion 25 .
  • a plurality of first absorption channels 76 a is disclosed, a single channel may suffice.
  • One end of the first absorption channel 76 a is open into the adjustment portion 16 side on the end face 15 a of the base part 15 .
  • the second absorption channel 76 b is formed substantially orthogonal to the axial direction of the base part 15 .
  • One end of the second absorption channel 76 b is open into a side surface portion side of the second member 12 .
  • the other end of the first absorption channel 76 a and that of the second absorption channel 76 b are arranged to communicate with each other so that the absorption part 76 is thus formed.
  • the medicine M that has been spilled during air removal is held in the concave portion 19 formed by the adjustment portion 16 and the stabilizer 17 .
  • the medicine M staying in the concave portion 19 is absorbed into the first absorption channel 76 a by virtue of capillarity (capillary action) and is retained in the first absorption channel 76 a and second absorption channel 76 b.
  • This configuration inhibits discharge of the medicine M that has been spilled during air removal and makes it possible to prevent the medicine from making contact with or attaching to the user.
  • the medicine injection device according to the disclosure is applied to an intracutaneous injection.
  • the disclosure is not limited to such application.
  • the medicine injection device may be applied to a subcutaneous injection and an intramuscular injection, with adjustment of the protrusion length of the medicine injection device.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US14/065,203 2011-04-28 2013-10-28 Injection needle assembly and medicine injection device Abandoned US20140052100A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/730,503 US10398851B2 (en) 2011-04-28 2017-10-11 Injection needle assembly and medicine injection device

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-101226 2011-04-28
JP2011101226 2011-04-28
PCT/JP2012/055094 WO2012147409A1 (ja) 2011-04-28 2012-02-29 注射針組立体及び薬剤注射装置

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/055094 Continuation WO2012147409A1 (ja) 2011-04-28 2012-02-29 注射針組立体及び薬剤注射装置

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/730,503 Division US10398851B2 (en) 2011-04-28 2017-10-11 Injection needle assembly and medicine injection device

Publications (1)

Publication Number Publication Date
US20140052100A1 true US20140052100A1 (en) 2014-02-20

Family

ID=47071937

Family Applications (2)

Application Number Title Priority Date Filing Date
US14/065,203 Abandoned US20140052100A1 (en) 2011-04-28 2013-10-28 Injection needle assembly and medicine injection device
US15/730,503 Active 2032-03-06 US10398851B2 (en) 2011-04-28 2017-10-11 Injection needle assembly and medicine injection device

Family Applications After (1)

Application Number Title Priority Date Filing Date
US15/730,503 Active 2032-03-06 US10398851B2 (en) 2011-04-28 2017-10-11 Injection needle assembly and medicine injection device

Country Status (5)

Country Link
US (2) US20140052100A1 (ja)
EP (1) EP2703028B1 (ja)
JP (1) JP5894582B2 (ja)
CN (1) CN103501846B (ja)
WO (1) WO2012147409A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160000646A1 (en) * 2014-07-07 2016-01-07 Mt.Derm Gmbh Application module for a handheld device for the repeated application of an application element to a human skin or to an animal skin, and handheld device
US20180043109A1 (en) * 2011-04-28 2018-02-15 Terumo Kabushiki Kaisha Injection needle assembly and medicine injection device
US10821238B2 (en) 2015-07-15 2020-11-03 Terumo Kabushiki Kaisha Intradermal injection needle for immunotherapy

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201307385D0 (en) * 2013-04-24 2013-06-05 Star Syringe Ltd Syringes
EP3202439B1 (en) * 2014-09-29 2022-01-12 Terumo Kabushiki Kaisha Medicine injection device
EP3721926A1 (en) 2015-06-01 2020-10-14 Becton, Dickinson and Company Reusable pen interface for disposable pen needle
JP7233219B2 (ja) 2016-04-08 2023-03-06 ベクトン・ディキンソン・アンド・カンパニー 患者接触表面を備えるシリンジ
GB2580133B (en) * 2018-12-21 2023-04-12 Janssen Pharmaceuticals Inc Accessory including a slot for a flange of an injection device
WO2022126652A1 (zh) * 2020-12-18 2022-06-23 苏州市立普医疗科技有限公司 一种活检针及活检装置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896805A (en) * 1972-05-19 1975-07-29 Kendall & Co Multi-chamber syringe
US4845923A (en) * 1987-08-06 1989-07-11 Donovan Dennis M Contaminated sharp object disposal method
JP3025843B2 (ja) * 1989-08-14 2000-03-27 武田薬品工業株式会社 注射針キャップ
US5339829A (en) * 1989-09-21 1994-08-23 Epitope, Inc. Oral collection device
US5728071A (en) * 1996-09-09 1998-03-17 Watson; Robert L. Injection patch
IT1298087B1 (it) * 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
JP2000217914A (ja) * 1999-02-01 2000-08-08 Arute:Kk 注射針プロテクター、注射針ユニット及びこれらを用いる注射器
US6502699B1 (en) * 2000-06-21 2003-01-07 Robert L. Watson Method and kit for making injections and withdrawing blood without the use of protective gloves
US8100857B2 (en) * 2001-07-25 2012-01-24 B. Braun Melsungen Ag Method and apparatus for indicating or covering a percutaneous puncture site
MXPA04002283A (es) * 2001-09-12 2004-06-29 Becton Dickinson Co Dispositivo de pluma a base de microaguja para el suministro de farmaco y metodo para utilizar el mismo.
JP4746545B2 (ja) * 2003-08-28 2011-08-10 ベクトン・ディキンソン・アンド・カンパニー 皮内注射装置
US20070060904A1 (en) 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
US20070093760A1 (en) * 2005-10-11 2007-04-26 Wexler Michael R Syringe with wound dressing material
US7842008B2 (en) * 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
JPWO2007063828A1 (ja) 2005-11-29 2009-05-07 株式会社ティー・ティー・エム 体液採取装置およびその方法
CA2770829C (en) * 2009-09-30 2017-05-16 Terumo Kabushiki Kaisha Injection needle assembly and drug injection device
EP2484397B1 (en) 2009-09-30 2015-01-21 Terumo Kabushiki Kaisha Syringe needle assembly and medication syringe device
JP5894582B2 (ja) * 2011-04-28 2016-03-30 テルモ株式会社 注射針組立体及び薬剤注射装置

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180043109A1 (en) * 2011-04-28 2018-02-15 Terumo Kabushiki Kaisha Injection needle assembly and medicine injection device
US10398851B2 (en) * 2011-04-28 2019-09-03 Terumo Kabushiki Kaisha Injection needle assembly and medicine injection device
US20160000646A1 (en) * 2014-07-07 2016-01-07 Mt.Derm Gmbh Application module for a handheld device for the repeated application of an application element to a human skin or to an animal skin, and handheld device
US10821238B2 (en) 2015-07-15 2020-11-03 Terumo Kabushiki Kaisha Intradermal injection needle for immunotherapy

Also Published As

Publication number Publication date
JP5894582B2 (ja) 2016-03-30
JPWO2012147409A1 (ja) 2014-07-28
CN103501846B (zh) 2016-02-10
US20180043109A1 (en) 2018-02-15
WO2012147409A1 (ja) 2012-11-01
US10398851B2 (en) 2019-09-03
EP2703028A1 (en) 2014-03-05
EP2703028B1 (en) 2021-03-24
CN103501846A (zh) 2014-01-08
EP2703028A4 (en) 2014-10-08

Similar Documents

Publication Publication Date Title
US10398851B2 (en) Injection needle assembly and medicine injection device
US10967134B2 (en) Injection needle assembly and medicine injection device
AU2010301899B2 (en) Syringe needle assembly and medication injection device
US8636705B2 (en) Injection needle assembly and medicine injection apparatus
EP2484397B1 (en) Syringe needle assembly and medication syringe device
TWI619523B (zh) 藥劑投入器具以及藥劑注射裝置
US9283330B2 (en) Injection needle assembly and drug injection apparatus
WO2012153563A1 (ja) 注射針組立体及び薬剤注射装置
WO2011040222A1 (ja) 注射針組立体及び薬剤注射装置
WO2012157318A1 (ja) 注射針組立体及び薬剤注射装置
WO2012157312A1 (ja) 注射針ユニット
WO2012132761A1 (ja) 注射針ユニット、収納ケース、注射針組立体及び薬剤注射装置

Legal Events

Date Code Title Description
AS Assignment

Owner name: TERUMO KABUSHIKI KAISHA, JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:IWASE, YOICHIRO;OGAWA, JUNICHI;TACHIKAWA, KOUICHI;SIGNING DATES FROM 20131111 TO 20131114;REEL/FRAME:033453/0576

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION