US20120082631A1 - Compositions - Google Patents
Compositions Download PDFInfo
- Publication number
- US20120082631A1 US20120082631A1 US13/266,995 US201013266995A US2012082631A1 US 20120082631 A1 US20120082631 A1 US 20120082631A1 US 201013266995 A US201013266995 A US 201013266995A US 2012082631 A1 US2012082631 A1 US 2012082631A1
- Authority
- US
- United States
- Prior art keywords
- maltol
- oral care
- care composition
- cyclotene
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 70
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims abstract description 72
- CFAKWWQIUFSQFU-UHFFFAOYSA-N 2-hydroxy-3-methylcyclopent-2-en-1-one Chemical compound CC1=C(O)C(=O)CC1 CFAKWWQIUFSQFU-UHFFFAOYSA-N 0.000 claims abstract description 68
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 claims abstract description 37
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229940043353 maltol Drugs 0.000 claims abstract description 34
- 229940093503 ethyl maltol Drugs 0.000 claims abstract description 33
- 239000001837 2-hydroxy-3-methylcyclopent-2-en-1-one Substances 0.000 claims abstract description 32
- 229910021645 metal ion Inorganic materials 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical group [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 14
- 239000011746 zinc citrate Substances 0.000 claims description 14
- 235000006076 zinc citrate Nutrition 0.000 claims description 14
- 229940068475 zinc citrate Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 150000003751 zinc Chemical class 0.000 claims description 4
- 235000019606 astringent taste Nutrition 0.000 abstract description 25
- 239000000796 flavoring agent Substances 0.000 description 14
- -1 ion salts Chemical class 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 13
- 239000000606 toothpaste Substances 0.000 description 13
- 229940034610 toothpaste Drugs 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 12
- 239000000551 dentifrice Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000001683 mentha spicata herb oil Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 235000019721 spearmint oil Nutrition 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- BLILOGGUTRWFNI-UHFFFAOYSA-N Monomenthyl succinate Chemical class CC(C)C1CCC(C)CC1OC(=O)CCC(O)=O BLILOGGUTRWFNI-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 150000004001 inositols Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Definitions
- This invention relates to a method of reducing the astringency of an oral care composition, to reduced astringency oral care compositions, and to the use of certain compounds to reduce astringency in oral care compositions.
- PVM polyvalent metal
- Astringency in respect to oral compositions, is defined as a complex group of sensations experienced when a substance causes the oral surfaces to feel rough, the mouth to feel dry, and the mucosal surfaces to tighten, draw or pucker.
- US Patent Application Publication No. 2008/0138298 discloses oral care compositions comprising 0.01-10% of polyphosphorylated inositol derivatives such as phytic acid. These compositions are said to be effective in preventing/controlling disease states whilst having improved aesthetics such as astringency.
- PVM ion salt astringency has been addressed using monomenthyl succinate salts (WO 98/11867) and poloxamer polymers (WO 00/32160).
- a method of reducing the astringency of an oral care composition containing PVM ion salts comprising the addition to an oral care composition of at least one of maltol (3-hydroxy-2-methyl-4H-pyran-4-one), ethyl maltol (2-ethyl-3-hydroxy-4H-pyran-4-one), and cyclotene (2-hydroxy-3-methyl-2-cyclopenten-1-one); such that the concentrations of maltol, ethyl maltol, and cyclotene in said oral care composition meet the criterion (M/50+E/50+C/250) ⁇ 1, particularly 1.0-1.5, more particularly 1.2-1.5; wherein M, E and C represent the concentration (in ppm by weight of the total oral care composition) of maltol, ethyl maltol, and cyclotene respectively.
- oral care composition refers to non-food compositions that are designed to be taken into the mouth to deliver a variety of benefits. Such compositions include dentifrices, mouthwashes, mouth sprays and gargle compositions, breath strips (edible films placed in the oral cavity to administer thereto an active agent such as a flavourant or breath-freshening agent), and chewing gums.
- dentifrice means toothpaste, oral care gels or liquids, unless otherwise specified.
- the dentifrice composition may be a single-phase composition or it may be a combination of two or more separate dentifrice compositions.
- the dentifrice composition may be in any desired form, such as deep striped, surface striped, multilayered, having the gel surrounding the paste, or any combination thereof.
- an oral care composition comprising at least one PVM ion salt, in particular a zinc salt, and an astringency-counteracting amount of at least one of maltol, ethyl maltol, and cyclotene, such that the concentrations in the said oral care composition of maltol, ethyl maltol, and cyclotene meet the criterion (M/50+E/50+C/250) ⁇ 1, particularly 1.0-1.5, more particularly 1.2-1.5; wherein M, E and C represent the concentration (in ppm by weight of the total oral care composition) of maltol, ethyl maltol, and cyclotene respectively.
- compositions comprising at least one of maltol, ethyl maltol, and cyclotene, for use in the reduction of the astringency of an oral care composition comprising a PVM ion salt, the concentrations of maltol, ethyl maltol, and cyclotene in the oral care composition being such that they meet the criterion (M/50+E/50+C/250) ⁇ 1, wherein M, E and C represent the concentration (in ppm by weight of the total oral care composition) of maltol, ethyl maltol, and cyclotene respectively.
- Maltol, ethyl maltol, and cyclotene may be used alone or in combination as the sole components in a composition. Alternatively they may be employed in conjunction with one or more other ingredients commonly used in the art.
- a method of forming an oral care composition comprising the addition to an oral care composition of at least one of maltol (3-hydroxy-2-methyl-4H-pyran-4-one), ethyl maltol (2-ethyl-3-hydroxy-4H-pyran-4-one), and cyclotene (2-hydroxy-3-methyl-2-cyclopenten-1-one); such that the concentrations in the oral care composition of maltol, ethyl maltol, and cyclotene meet the criterion (M/50+E/50+C/250) ⁇ 1, particularly 1.0-1.5, more particularly 1.2-1.5; wherein M, E and C represent the concentration (in ppm by weight of the total oral care composition) of maltol, ethyl 15 maltol, and cyclotene respectively.
- Maltol, ethyl maltol, and cyclotene , or compositions containing one or more said compounds can be added to oral care compositions by using conventional techniques to directly admix the said compounds, or composition into the oral care composition.
- the concentrations of maltol, ethyl maltol, and cyclotene that may be employed in the abovementioned oral care compositions will depend on the concentration of PVM ion salts in the oral care composition. It will also depend on the particular sensorial effect that the formulator is trying to achieve, as these materials are flavoured and, depending on the nature of other flavour ingredients present, may influence the overall hedonic or sensorial effect of the oral care composition.
- maltol may be employed at levels of at least 50 ppm, more particularly 100 ppm, still more particularly 250 ppm.
- ethyl maltol may be employed at levels of at least 50 ppm, more particularly 100 ppm, still more particularly 250 ppm.
- cyclotene may be employed at levels of at least 250 ppm, more particularly 500 ppm, still more particularly 750 ppm.
- cyclotene is combined with one or both of maltol and ethyl maltol at levels mentioned hereinabove.
- cyclotene is combined with one or both of maltol and ethyl maltol in a ratio of 1:10 to 10:1, more particularly 1:5 to 5:1.
- PVM ion salts employed in oral care products can cause astringency.
- Typical PVM ion salts used in oral care compositions of the present invention are zinc salts, particularly zinc chloride, zinc citrate, zinc acetate, and zinc sulphate, more particularly zinc citrate.
- the proportion of PVM ion salts usually employed is 0.1 to 2% by weight of the total oral care composition.
- the reduced astringency oral care compositions of the present invention may also comprise one or more additional ingredients or excipients conventionally used in conjunction with oral 20 care compositions for example, additional flavour compounds and other auxilliary agents commonly used in the art.
- Differing flavour ingredients were added, at a concentration of 1000 ppm, to a non-flavoured toothpaste base containing 0.75% zinc citrate (ZCT).
- ZCT zinc citrate
- Table 1 lists the flavour ingredients added to the non-flavoured toothpaste base containing 0.75% zinc citrate, along with the mean astringency rating of each sample. Also included in table 1 is the mean astringency rating of the non-flavoured toothpaste base containing 0.75% ZCT and the current market product.
- the toothpaste compositions comprising the flavour materials of the invention, maltol ethyl maltol and cycoltene, all showed significantly lower astringency ratings compared to those of the standard toothpaste base and the current market product.
- Example compositions containing 2% Zinc Citrate with varying amounts of maltol, ethyl maltol and cyclotene are shown in Table 2.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0907925.2 | 2009-05-08 | ||
| GBGB0907925.2A GB0907925D0 (en) | 2009-05-08 | 2009-05-08 | Composition |
| PCT/EP2010/056329 WO2010128164A2 (en) | 2009-05-08 | 2010-05-10 | Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20120082631A1 true US20120082631A1 (en) | 2012-04-05 |
Family
ID=40833678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/266,995 Abandoned US20120082631A1 (en) | 2009-05-08 | 2010-05-10 | Compositions |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120082631A1 (pt) |
| EP (1) | EP2427248A2 (pt) |
| BR (1) | BRPI1011570A2 (pt) |
| GB (1) | GB0907925D0 (pt) |
| MX (1) | MX2011011713A (pt) |
| WO (1) | WO2010128164A2 (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108883098A (zh) * | 2016-01-19 | 2018-11-23 | 雅珂马Z私人有限公司 | 用于调整肤质的化妆品组合物及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762215A1 (en) * | 2005-09-13 | 2007-03-14 | Unilever N.V. | Oral care composition |
| US20070231278A1 (en) * | 2006-03-29 | 2007-10-04 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
| WO2008122286A1 (en) * | 2007-04-04 | 2008-10-16 | Gumlink A/S | Center-filled chewing gum product for dental care |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1048981A (zh) * | 1989-07-28 | 1991-02-06 | 黄国刚 | 菊花制品去生青、苦涩气味法及配方 |
| US6306372B1 (en) * | 2000-06-21 | 2001-10-23 | Noville Inc. | Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc |
| JP4897574B2 (ja) * | 2007-05-31 | 2012-03-14 | 花王株式会社 | 容器詰飲料 |
-
2009
- 2009-05-08 GB GBGB0907925.2A patent/GB0907925D0/en not_active Ceased
-
2010
- 2010-05-10 WO PCT/EP2010/056329 patent/WO2010128164A2/en active Application Filing
- 2010-05-10 MX MX2011011713A patent/MX2011011713A/es not_active Application Discontinuation
- 2010-05-10 EP EP10720387A patent/EP2427248A2/en not_active Withdrawn
- 2010-05-10 BR BRPI1011570A patent/BRPI1011570A2/pt not_active IP Right Cessation
- 2010-05-10 US US13/266,995 patent/US20120082631A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762215A1 (en) * | 2005-09-13 | 2007-03-14 | Unilever N.V. | Oral care composition |
| US20070231278A1 (en) * | 2006-03-29 | 2007-10-04 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
| WO2008122286A1 (en) * | 2007-04-04 | 2008-10-16 | Gumlink A/S | Center-filled chewing gum product for dental care |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108883098A (zh) * | 2016-01-19 | 2018-11-23 | 雅珂马Z私人有限公司 | 用于调整肤质的化妆品组合物及其用途 |
| US20190021974A1 (en) * | 2016-01-19 | 2019-01-24 | Achromaz Pte. Ltd. | A Cosmetic Composition and the Use Thereof for Regulating Skin Quality |
| US11123279B2 (en) * | 2016-01-19 | 2021-09-21 | Achromaz Pte. Ltd. | Cosmetic composition and the use thereof for regulating skin quality |
| AU2017209950B2 (en) * | 2016-01-19 | 2022-11-17 | Achromaz Pte. Ltd. | A cosmetic composition and the use thereof for regulating skin quality |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010128164A3 (en) | 2011-12-29 |
| WO2010128164A2 (en) | 2010-11-11 |
| GB0907925D0 (en) | 2009-06-24 |
| EP2427248A2 (en) | 2012-03-14 |
| BRPI1011570A2 (pt) | 2016-04-05 |
| MX2011011713A (es) | 2011-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2812028C (en) | Methods for improving taste and oral care compositions with improved taste | |
| RU2605297C2 (ru) | Композиции для уменьшения ощущений, вызванных рецепторами trpa1 и trpv1 | |
| US20150125404A1 (en) | Oral Care Compositions With Improved Rheology | |
| US20200297595A1 (en) | Oral Care Compositions With An Enhanced Sensory Experience | |
| AU2011308820A1 (en) | Oral care compositions with improved sweetness | |
| JP2020011951A (ja) | 口腔用組成物 | |
| EP2775995B1 (en) | Alcohol-free mouthwash | |
| JP5729291B2 (ja) | 口腔用組成物 | |
| US9884130B2 (en) | Compositions for delivery of oral comfort sensations | |
| US20120082631A1 (en) | Compositions | |
| JP5825088B2 (ja) | 液体口腔用組成物 | |
| JP6610208B2 (ja) | 口腔用組成物 | |
| US20240091111A1 (en) | Methods of masking off-tastes | |
| JP2002212041A (ja) | 口腔用組成物 | |
| JP7172392B2 (ja) | 口腔用組成物 | |
| CA2956966C (en) | Dentifrice with incremental chemistries | |
| JP2001322921A (ja) | 液体口腔用組成物 | |
| KR20220035868A (ko) | 구강용 조성물 및 잇몸에의 마사지 실감 부여제 | |
| WO2023074725A1 (ja) | 液体口腔用組成物 | |
| JP2023065995A (ja) | 液体口腔用組成物 | |
| JP2010013487A (ja) | 口腔用組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: GIVAUDAN SA, SWITZERLAND Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BRADSHAW, DAVID JONATHAN;CAWKILL, PAULA MARIA;DOWNEY, ROY;AND OTHERS;SIGNING DATES FROM 20111020 TO 20111026;REEL/FRAME:027345/0821 |
|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |