US20110089041A1 - Methods of depositing discrete hydroxyapatite regions on medical implants - Google Patents
Methods of depositing discrete hydroxyapatite regions on medical implants Download PDFInfo
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- US20110089041A1 US20110089041A1 US12/581,483 US58148309A US2011089041A1 US 20110089041 A1 US20110089041 A1 US 20110089041A1 US 58148309 A US58148309 A US 58148309A US 2011089041 A1 US2011089041 A1 US 2011089041A1
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- electrolyte solution
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D9/00—Electrolytic coating other than with metals
- C25D9/04—Electrolytic coating other than with metals with inorganic materials
- C25D9/08—Electrolytic coating other than with metals with inorganic materials by cathodic processes
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
- C25D5/18—Electroplating using modulated, pulsed or reversing current
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
- C25D5/48—After-treatment of electroplated surfaces
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
- C25D5/60—Electroplating characterised by the structure or texture of the layers
- C25D5/615—Microstructure of the layers, e.g. mixed structure
- C25D5/617—Crystalline layers
Definitions
- the present technology relates to medical implants having discrete regions of a calcium phosphate (e.g., hydroxyapatite), and methods of their manufacture.
- a calcium phosphate e.g., hydroxyapatite
- CPP calcium phosphate phase
- Hydroxyapatite is a biocompatible material similar in composition to the mineral content of natural bone.
- hydroxyapatite coatings on medical orthopedic implants can enhance the implant's osteoconductive potential, among other things.
- CPP coatings can be deposited onto electroconductive, or metal substrates using solution-based techniques, such as electrochemical deposition or sol-gel deposition.
- One advantage of using such deposition processes is that they are not “line of sight” processes and thus can provide a complete coating coverage of complex shaped substrates. With the use of implants having nano-scale texturing, however, such deposition processes can be disadvantageous in that the coating may be applied over the nano-scale texturing, thereby negating its affect. Accordingly, there remains a need to provide methods for using electrochemical deposition techniques to provide discrete regions of CPP, including hydroxyapatite.
- the present technology provides methods for electrochemically depositing one or more discrete regions of a calcium phosphate onto a medical implant.
- the implant has at least one area having an electroconductive surface. At least a portion of the electroconductive surface is contacted with an electrolyte solution comprising calcium ions and phosphate ions. An electrical potential is applied between the electroconductive surface and the electrolyte solution. A plurality of discrete regions of a calcium phosphate phase is formed onto the electroconductive surface, wherein the calcium phosphate phase comprises a needle-shaped morphology.
- the method for electrochemically depositing discrete regions of a calcium phosphate phase onto a medical implant includes providing an implant including at least one area having a metallic surface. At least a portion of the metallic surface is contacted with an electrolyte solution comprising calcium ions and phosphate ions. The metallic surface is used as a cathode, and an electrical potential is applied between the cathode and the electrolyte solution. The electrical potential is applied with a constant current density of from about 10 to about 50 mA/cm 2 for a period of time of between about 1 to about 20 minutes. A plurality of discrete regions of needle-shaped hydroxyapatite crystals is electrochemically deposited onto the metallic surface.
- the present technology also provides processes for making a plurality of medical implants having discrete regions of calcium phosphate phase.
- Such processes include preparing an electrolyte solution comprising calcium ions and phosphate ions having a concentration ratio of calcium:phosphate of about 1.7:1.
- a plurality of implants is placed into the electrolyte solution, wherein each implant comprises at least one area having an electroconductive surface.
- the electroconductive surfaces are used as cathodes and an electrical potential is applied between the cathodes and the electrolyte solution, wherein the electrical potential has a constant current density of from about 10 to about 50 mA/cm 2 .
- the electrical potential can be applied for a period of time of between about 1 to about 20 minutes.
- the process includes electrochemically depositing a plurality of discrete regions of needle-shaped hydroxyapatite crystals onto the electroconductive surfaces.
- FIG. 1 is a SEM micrograph magnified about 80,000 ⁇ illustrating discrete regions of hydroxyapatite deposited on a titanium substrate and having a needle-like morphology;
- FIGS. 2 and 3 are SEM micrographs magnified about 10,000 ⁇ illustrating discrete regions of hydroxyapatite deposited on a titanium substrate having a needle-like morphology.
- the words “desirable”, “preferred” and “preferably” refer to embodiments of the technology that afford certain benefits, under certain circumstances. However, other embodiments may also be preferred or desirable, under the same or other circumstances. Furthermore, the recitation of one or more preferred or desired embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the technology.
- the word “include,” and its variants, is intended to be non-limiting, such that recitation of items in a list is not to the exclusion of other like items that may also be useful in the materials, compositions, devices, and methods of this technology.
- the terms “can” and “may” and their variants are intended to be non-limiting, such that recitation that an embodiment can or may comprise certain elements or features does not exclude other embodiments of the present technology that do not contain those elements or features.
- compositions or processes specifically envisions embodiments consisting of, and consisting essentially of, A, B and C, excluding an element D that may be recited in the art, even though element D is not explicitly described as being excluded herein.
- compositional percentages are by weight of the total composition, unless otherwise specified. Disclosures of ranges are, unless specified otherwise, inclusive of endpoints. Thus, for example, a range of “from A to B” or “from about A to about B” is inclusive of A and of B. Disclosure of values and ranges of values for specific parameters (such as temperatures, molecular weights, weight percentages, etc.) are not exclusive of other values and ranges of values useful herein. It is envisioned that two or more specific exemplified values for a given parameter may define endpoints for a range of values that may be claimed for the parameter.
- Parameter X is exemplified herein to have value A and also exemplified to have value Z, it is envisioned that Parameter X may have a range of values from about A to about Z.
- disclosure of two or more ranges of values for a parameter (whether such ranges are nested, overlapping or distinct) subsume all possible combination of ranges for the value that might be claimed using endpoints of the disclosed ranges.
- Parameter X is exemplified herein to have values in the range of 1-10, or 2-9, or 3-8, it is also envisioned that Parameter X may have other ranges of values including 1-9, 1-8, 1-3, 1-2, 2-10, 2-8, 2-3, 3-10, and 3-9.
- the present technology provides methods for electrochemically depositing discrete regions of a calcium phosphate phase onto a medical implant.
- Titanium and its alloys, in addition to other metal substrates, are becoming increasingly popular as implant materials due to their favorable biocompatibility and favorable mechanical and chemical properties.
- Calcium phosphate phases (CPP) have a lot of bioactive potential, thus enabling chemical bonding to natural bone.
- the main inorganic constituent CPP may contain amorphous calcium phosphate (Ca 9 (PO 4 ) 6 .nH 2 O), hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), octacalcium phosphate (Ca 8 H 2 (PO) 6 H 2 O), or brushite (CaHPO 4 .2H 2 O), or mixtures thereof
- the CPP can additionally be doped with ions such as fluoride, silver, magnesium, carbonate, strontium, or sodium.
- hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) is a CPP biocompatible material that is similar in composition to the major inorganic mineral content of natural bone.
- hydroxyapatite coatings provided on metallic or otherwise electroconductive medical implants can enhance an implant's osteoconductivity potential.
- Common deposition techniques for coating hydroxyapatite onto implants can include plasma spray coating, electrochemical deposition, and sol-gel deposition. While plasma spray coating is a widely used method, its high process conditions (high temperature) can result in coating properties that deviate from the mineral phase of bone, especially with respect to crystal structure and solubility.
- the high process temperatures may cause partial decomposition of hydroxyapatite, resulting in the formation of other CPP, including amorphous calcium phosphate (ACP), ⁇ -tricalcium phosphate (TCP), ⁇ -TCP, tetracalcium phosphate, and calcium oxide.
- ACP amorphous calcium phosphate
- TCP ⁇ -tricalcium phosphate
- ⁇ -TCP ⁇ -TCP
- tetracalcium phosphate calcium oxide
- ACP phase energetically favored places
- the ACP is then transformed to the crystalline phase of hydroxyapatite.
- small calcium phosphate precursor island regions are first formed that coalesce and form a continuous, homogeneous pre-layer on the metal surface. Both the pre-layer and the spheres comprise clusters of Ca 3 (PO 4 ) 2 from which preferential crystalline hydroxyapatite needles grow:
- a more efficient means of hydroxyapatite deposition may include the direct deposition of hydroxyapatite crystalline onto a metal substrate, or a more timely transformation to the crystalline phase.
- Such a direct application can be beneficial where surfaces of the implant include nano-scale texturing or etching.
- the present technology provides an electrochemical deposition process to facilitate an early transition from ACP to discrete deposition regions of hydroxyapatite crystalline, without the formation of a continuous layer of ACP as one would expect with such a deposition process. Unless one painstakingly masks various areas of the implant prior to the treatment, the typical electrochemical deposition process will first provide a continuous coating layer over the entire implant that is subsequently transformed into hydroxyapatite. Such a continuous coating would likely negate the various benefits obtained from any nano-scale etching or texturing.
- the present technology surprisingly provides the electrochemical deposition of discrete regions of CPP, and hydroxyapatite in particular, onto the surface of a medical implant.
- the present technology affects the kinetics of reaction, which can be controlled with the appropriate electrochemical parameters, as discussed below.
- it provides a CPP deposition that is predominantly needle-shaped hydroxyapatite after only a short duration of time.
- from about 70 to about 90 percent, or from about 85 to about 90 percent of the discrete CPP regions may have a crystalline structure, while only from about 10 to about 30 percent of the CPP may be an amorphous phase.
- This can provide for calcium phosphate regions of variable solubility.
- it may be preferred that the hydroxyapatite has a random orientation.
- a medical implant including at least one area having an electroconductive surface.
- the electroconductive surface can be a discrete area or it can be a continuous area covering the surface of the entire implant.
- the surface can be provided with nano-scale texturing, if desired.
- Such an electroconductive surface can comprise a material selected from the group consisting of titanium, a titanium alloy, titanium nitrate, a CoCrMo alloy, stainless steel, an electroconductive polymer, and mixtures thereof.
- the electrochemical deposition can be carried out in an electrolysis cell, or bath, in which the implant, as least the metallic or otherwise electroconductive surface, is cathodically polarized.
- a three-electrode arrangement can be made including a calomel electrode used as a reference electrode, a platinum sheet or gauze used as the counter electrode, and the metallic implant provided as the cathode.
- the deposition process can take place biomimetically, near physiological pH and temperature conditions.
- the electroconductive surface is placed in contact with an electrolyte solution comprising calcium ions and phosphate ions.
- the electrolyte can comprise a Ca 2+ /H x PO 4 (3-x)- containing solution.
- the ratio of the concentration of the calcium ions and the phosphate ions is chosen such that it is equal or at least equivalent to their concentrations in hydroxyapatite.
- the electrolyte solution may include calcium chloride, calcium chloride dihydrate, or calcium acetate as the source of calcium ions, and ammonium dihydrogen phosphate as the source of phosphate ions. The choice of the particular salts used may be based on availability.
- the electrolyte solution is prepared using solutions that correspond to a final concentration of calcium:phosphate of about 1.7:1 (e.g., 1.67:1).
- a final concentration of calcium:phosphate of about 1.7:1 e.g., 1.67:1
- various embodiments currently provide for a standard-like concentration of calcium ions of about 1.7 mM (e.g., 1.7 mM) and a concentration of phosphate ions of about 1.0 mM.
- concentration may call for the electrical potential to be applied for from about 1 to about 5 minutes, preferably about 2.5 minutes, in order to obtain desired deposition.
- an addition modification includes applying the electrical potential having a similar current density for a slightly longer period of time. With such a lower concentration of ions, the electrical potential can be applied for from about 1 to about 20 minutes, or from about 5 to about 15 minutes, such as about 10 minutes, in order to obtain desired deposition.
- the current density will still be applied at about the same level, or slightly lower, as will be discussed. It should be understood that the actual current density required may vary for each different type of component processed, and may depend upon the total surface area and surface finish, as well as the power sources available.
- an electrical potential is applied between the electroconductive surface and the electrolyte solution.
- the present technology provides applying an electrical potential having a constant current density of from about 10 to about 50 mA/cm 2 for a period of time of from about 1 to about 20 minutes.
- the electrical potential can be applied having a constant current density of from about 20 to about 40 mA/cm 2 for a period of time of from about 2 to about 10 minutes.
- the present technology provides beginning with an electrolyte solution containing calcium and phosphate ions and leading to the predominant electrochemical deposition of highly desirable hydroxyapatite crystalline having needle-shaped morphology on the surface of an implant.
- the hydroxyapatite is deposited as homogeneous and discrete island type regions.
- an implant includes any nano-scale texturing, it is not covered by a complete coating of an amorphous calcium phosphate phase, as it would be with conventional electrochemical deposition techniques.
- the morphology of the hydroxyapatite crystals can be visually described as needle-like or needle-shaped, and in various embodiments having needles with dimensions of less than about 500 nm in length and less than about 60 nm in width, and in some embodiments less than about 30 nm in width.
- Typical needle lengths may be from about 200 and about 300 nm in certain embodiments, or from about 90 and about 140 nm in other embodiments.
- Electrochemical deposition of a calcium phosphate phase depends in part on the pH-dependent solubility of the calcium phosphate, which has been found to decrease with increasing pH.
- electrochemical deposition process one can control the pH at the cathode/electrolyte interface.
- the following reactions occur at the surface of the cathode (reduction of water, proton discharge, and reduction of dissolved oxygen):
- the pH of the electrolyte solution is maintained at from about 3 to about 7, or from about 5 to about 7, using hydrochloric acid or ammonium hydroxide.
- the electrolyte solution can be maintained slightly acidic, for example, at a level of from about 5 to about 6. This slightly acidic environment allows for the partial dissolution of the CPP to occur in equilibrium with the precipitation and deposition processes.
- the present technology provides placing the implants in a bath containing the electrolyte solution and rotating the implants during application of the electrical potential.
- the present technology also provides for larger scale processes for making a plurality of medical implants having discrete regions of a calcium phosphate phase deposited thereon. It is envisioned that the process can treat from 2 up to 70 or more implants at one time, depending upon the size and surface area of the implants, as well as the desired electrochemical deposition parameters, including the available power supply.
- the process can include preparing an electrolyte solution comprising calcium ions and phosphate ions having a concentration ratio of calcium:phosphate of about 1.7:1 as previously described.
- a plurality of implants is then placed into the electrolyte solution, or bath. Any debris on the implant surface may lead to uncoated areas. Accordingly, the implants can optionally be cleaned prior to the deposition process, for example using an appropriate ultrasonic type wash.
- the electrolyte solution is provided in an inner bath container that is placed or disposed within an appropriate outer bath container.
- the outer bath container can be provided with circulating water to maintain a consistent temperature of the inner bath, for example, at about ambient temperature or alternatively about 37° C.
- Each implant comprises at least one area having an electroconductive surface which, in various embodiments, includes a metallic area or surface. These electroconductive surfaces are appropriately connected and used as the cathodes for cathodic polarization.
- a constant electrical potential is applied between the cathodes and the electrolyte solution, wherein the electrical potential has a constant current density of from about 10 to about 50 mA/cm 2 .
- the electrical potential can be applied for a period of time of from about 1 to about 20 minutes depending on the remaining deposition parameters and desired amount of hydroxyapatite deposition.
- the process includes electrochemically depositing a plurality of discrete regions of needle-shaped hydroxyapatite crystals onto the electroconductive surfaces.
- the implants can be appropriately rotated during the application of electrical potential, depending on the amount of hydrogen bubbling that may occur.
- the implants can be removed and sent to a rinsing station.
- the implants can also be sent to an appropriate anodizing station.
- Such an anodizing bath may be provided including deionized water, trisodium phosphate dodecahydrate, and di-potasium hydrogen phosphate at ambient temperature.
- the electrochemical deposition process may be carried out by cathodic polarization in a number of successive, repeated process cycles.
- a process cycle may include cathodic polarization in one or more successive steps, in certain embodiments during at least two discrete intervals of time, with identical or different (increased or decreased) constant current densities, and a rinsing and/or drying phase following thereon.
- a disc of Ti6Al4V having a radius of about 0.5 inches and a thickness of 0.25 inches is prepared with a smooth machine finish, cleaned in an ultrasonic bath, and rinsed with distilled water. The thickness portion is masked and the disc sample is placed into an electrolyte solution at ambient temperature including 150 ml each of a stock solution of CaCl 2 and NH 4 H 2 PO 4 in concentrations of 33 mM and 20 mM, respectively. Deionized water is added providing a 3 L total volume solution having a final concentration of 1.67 mM calcium ions and 1.0 mM phosphate ions. The pH is adjusted to 5.1 using hydrochloric acid.
- electrochemical deposition is carried out by means of galvanostatic polarization under cathodic current flow at a current density of about 40 mA/cm 2 in order to provide a high flux of ions toward the cathode.
- cathodic polarization is complete and the sample is removed and rinsed with deionized water.
- Electron microscopic examination reveals a plurality of discrete but homogenous regions of CPP having needle like morphology as shown in FIG. 1 . Further IR-spectroscopic investigations provide proof that the discrete crystalline mineral phase comprises hydroxyapatite.
- a disc of Ti6Al4V is prepared as in Example 1.
- the disc sample is placed into an electrolyte solution at ambient temperature including 15 ml each of a stock solution of CaCl 2 and NH 4 H 2 PO 4 in concentrations of 33 mM and 20 mM, respectively.
- Deionized water is added providing a 3 L total volume solution having a final concentration of 0.167 mM calcium ions and 0.1 mM phosphate ions.
- the pH is adjusted to 6.4 using ammonium hydroxide.
- electrochemical deposition is carried out by means of galvanostatic polarization under cathodic current flow at a current density of about 20 mA/cm 2 in order to provide a high flux of ions toward the cathode.
- cathodic polarization is complete and the sample is removed and rinsed with deionized water.
- Electron microscopic examination reveals a plurality of discrete but homogenous regions of CPP having needle like morphology as shown in FIG. 2 . Further IR-spectroscopic and X-ray diffraction investigations provide proof that the discrete crystalline mineral phase comprises hydroxyapatite.
- a disc of Ti6Al4V is prepared as in Example 1.
- the disc sample is placed into an electrolyte solution at ambient temperature including 15 ml each of a stock solution of CaCl 2 and NH 4 H 2 PO 4 in concentrations of 33 mM and 20 mM, respectively.
- Deionized water is added providing a 3 L total volume solution having a final concentration of 0.167 mM calcium ions and 0.1 mM phosphate ions.
- the pH is adjusted to 6.4 using ammonium hydroxide.
- electrochemical deposition is carried out by means of galvanostatic polarization under cathodic current flow at a current density of about 30 mA/cm 2 in order to provide a high flux of ions toward the cathode.
- cathodic polarization is complete and the sample is removed and rinsed with deionized water.
- Electron microscopic examination reveals a plurality of discrete but homogenous regions of CPP having needle like morphology as shown in FIG. 3 . Further IR-spectroscopic and X-ray diffraction investigations provide proof that the discrete crystalline mineral phase comprises hydroxyapatite.
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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US12/581,483 US20110089041A1 (en) | 2009-10-19 | 2009-10-19 | Methods of depositing discrete hydroxyapatite regions on medical implants |
EP10773461.8A EP2491167B1 (fr) | 2009-10-19 | 2010-10-19 | Procédés de dépôt de régions individuelles d'hydroxyapatite sur des implants médicaux |
PCT/US2010/053138 WO2011049915A2 (fr) | 2009-10-19 | 2010-10-19 | Procédés de dépôt de régions individuelles d'hydroxyapatite sur des implants médicaux |
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US12/581,483 US20110089041A1 (en) | 2009-10-19 | 2009-10-19 | Methods of depositing discrete hydroxyapatite regions on medical implants |
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US12/581,483 Abandoned US20110089041A1 (en) | 2009-10-19 | 2009-10-19 | Methods of depositing discrete hydroxyapatite regions on medical implants |
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WO2015001366A3 (fr) * | 2013-05-27 | 2015-03-05 | Bay Zoltán Közhasznú Nonprofit Kft | Procédé de production d'un implant métallique possédant des propriétés antimicrobiennes et biocompatibles, et implant métallique correspondant |
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Also Published As
Publication number | Publication date |
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EP2491167A2 (fr) | 2012-08-29 |
EP2491167B1 (fr) | 2019-07-10 |
WO2011049915A3 (fr) | 2013-01-03 |
WO2011049915A2 (fr) | 2011-04-28 |
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