Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K38/00—Medicinal preparations containing peptides
  • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
  • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
  • A61K38/13—Cyclosporins
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/10—Dispersions; Emulsions
  • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/06—Antipsoriatics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/16—Emollients or protectives, e.g. against radiation
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q3/00—Manicure or pedicure preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q3/00—Manicure or pedicure preparations
  • A61Q3/02—Nail coatings

Definitions

• the present application is directed to compositions for enhancing nail and cuticle growth.
• Nails including toenails and fingernails, are primarily composed of the protein keratin. Fingernails and toenails are living tissue.
• the nail is formed in a pocket of skin which has grown inward and is called the nail matrix. This area generates the nail and is also called the root of the nail.
• the outer layer of the matrix contains specialized cells that create the keratin that grows out as the nail plate.
• the nail plate is the commonly referred to as a fingernail or toenail.
• the nail bed is the finger tissue or toe tissue that supports the nail. Nails grow continuously throughout a person's life, growing approximately at an average rate of 3 millimeters a month. Fingernails may require 3 to 6 months to re-grow completely, and toenails require approximately 12 to 18 months. Actual growth rate is dependent upon age, gender, season, exercise level, diet, and hereditary factors.
• fingernail and toe nail problems due to various conditions such as anemia, vitamin or mineral deficiency, onycohrrhexis, kidney and liver disorders, psoriasis, vascular disease (e.g., Raynaud's disease) and heart disease often result in poor nail growth, vertical trenches, pitting, cracking, horizontal lines, lack of thickness and strength, lack of smoothness and tendency to tear remains a significant problem.
• vascular disease e.g., Raynaud's disease
• heart disease often result in poor nail growth, vertical trenches, pitting, cracking, horizontal lines, lack of thickness and strength, lack of smoothness and tendency to tear remains a significant problem.
• the present invention is directed to compositions and methods for stimulating the growth of nails (including both toenails and fingernails) and cuticles (eponychium) in a mammal, including humans.
• the compositions may be administered topically to the nail bed, nail matrix, the end or tip of the nail and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail and cuticle.
• the composition may be administered once a day, twice a day, three times a day, four times a day, twice a week, three times a week, four times a week, five times a week and six times a week.
• the composition may come in a kit comprising a vial or dispenser containing the composition and an applicator brush.
• compositions of the present invention include but are not limited to emulsions, microemulsions, reverse emulsions, solutions, colloids, suspensions, dispersions, gels, pastes and polishes and may optionally contain an active compound such as cyclosporine, in particular, cyclosporine A retinoids (including but not limited to tazortene), biotin, and silicone may be included.
• an active compound such as cyclosporine, in particular, cyclosporine A retinoids (including but not limited to tazortene), biotin, and silicone may be included.
• the present invention is directed to oil-in-water emulsions optionally containing an active compound wherein the emulsions may contain at least one oil and/or surfactant.
• the emulsion contains castor oil, polysorbate 80, glycerine, NaOH and may optionally contain polyacrylates such as carbomer and PEMULEN® and other additional ingredients.
• One possible solution of the present invention includes 0.5% w/v carboxy methyl cellulose, 0.9% w/v glycerine, 0.25% carnitine and 0.25% w/v erythritol and purite.
• Other preferred emulsions of the present invention are described in the Examples below which optionally may omit or contain cyclosporine A:
• Example 1 A B C D E Cyclosporin A 0.40% 0.20% 0.20% 0.10% 0.05% Castor Oil 5.00% 5.00% 2.50% 1.25% 0.625% Polysorbate 80 1.00% 1.00% 1.00% 1.00% 1.00% 1.00% 1.00% Pemulen ® 0.05% 0.05% 0.05% 0.05% 0.05% Glycerine 2.20% 2.20% 2.20% 2.20% NaOH qs qs qs qs qs Purified water qs qs qs qs qs pH 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7.6 7.2-7
• Castor oil or another oil or another hydrophobic component such as vegetable oils, animal oils, mineral oils, synthetic oils, higher fatty acid glycerides and the like and mixtures thereof, some of which are listed below in the Detailed Description of the Invention, may be present in the composition in concentrations from 1.25% w/v, 0.01%-w/v-10.0% w/v, 0.1% w/v-5.0% w/v, 0.1% w/v-4.0% w/v, 0.1% w/v-3.0% w/v, 0.1% w/v-2.0% w/v, 0.1% w/v-1.0% w/v, 0.1% w/v-0.9% w/v, 0.1% w/v-0.8% w/v, 0.1% w/v-0.8% w/v, 0.1% w/v-0.7% w/v, 0.1% w/v-0.6% w/v, 0.1% w/v-0.5% w/v, 0.1% w/v-0.4
• Polysorbate 80 or another suitable surfactant such as alcohols including carboxylated and ethoxylated alcohols, amine oxides, block polymers, fatty acids including carboxylic fatty acids, ethoxylated alkyl phenols, ethoxylated fatty esters, glycerol esters, lanolin-based derivatives, lignin derivatives, methyl esters, mono- and tri-glycerides, polyethylene glycols, polymeric surfactants, propoxylated and ethoxylated fatty acids, alcohols, or alkyl phenols, protein based surfactants, sucrose and glucose esters and derivatives, some of which are listed below in the Detailed Description of the Invention, may be present in concentrations of a the preferred amount of 1.0% w/v or 0.01%-w/v-10.0% w/v, 0.1% w/v-5.0% w/v, 0.1% w/v-4.0% w/v, 0.1% w/v-3.0%
• Pemulen TR-2 or carbomer 1342, or other polymers or polymers of acrylic acid which are well known in the art can be present in the amounts of 0.05% w/w or 0.01%-w/v-10.0% w/v, 0.1% w/v-5.0% w/v, 0.1% w/v-4.0% w/v, 0.1% w/v-3.0% w/v, 0.1% w/v-2.0% w/v, 0.1% w/v-1.0% w/v, 0.1% w/v-0.9% w/v, 0.1% w/v-0.8% w/v, 0.1% w/v-0.7% w/v, 0.1% w/v-0.6% w/v, 0.1% w/v-0.5% w/v, 0.1% w/v-0.4% w/v, 0.1% w/v-0.3% w/v, 0.1% w/v-0.2% w/v, 0.09%-0.1% w/v, 0.0
• Glycerine and mannitol, or other tonicity adjusters which are known in the art can be present in the amounts of 1.0% w/w or 2.0% w/w respectively, or 0.01%-w/v-10.0% w/v, 0.1% w/v-5.0% w/v, 0.1% w/v-4.0% w/v, 0.1% w/v-3.0% w/v, 0.1% w/v-2.0% w/v, 0.1% w/v-1.0% w/v, 0.1% w/v-0.9% w/v, 0.1% w/v-0.8% w/v, 0.1% w/v-0.7% w/v, 0.1% w/v-0.6% w/v, 0.1% w/v-0.5% w/v, 0.1% w/v-0.4% w/v, 0.1% w/v-0.3% w/v, 0.1% w/v-0.2% w/v, 0.09%-0.1% w/v
• One preferred emulsion of the present invention contains: 1.0% w/w polysorbate 80, 0.05% w/w glycerine, 1.0% w/w castor oil, 0.08% w/w pemulin TR-2, 1.5% w/w mannitol, sodium hydroxide to a pH of 7.4 and purified water.
• Another preferred emulsion of the present invention contains: 1.0% w/w polysorbate 80, 1.0% w/w glycerine, 1.25% w/w castor oil, 0.05% w/w pemulin TR-2, 2.0% w/w mannitol, sodium hydroxide to a pH of 7.4 and purified water.
• Another preferred emulsion contains: 1.5% w/w polysorbate 80, 0.05% w/w glycerine, 0.05% w/w castor oil, 0.08% w/w pemulin TR-2, 1.5% w/w mannitol, sodium hydroxide to a pH of 7.4 and purified water.
• Another preferred emulsion of the present invention contains 1.2% w/w polysorbate 80, 1.0% w/w glycerine, 1.50% w/w castor oil, 0.05% w/w pemulin TR-2, 2.5% w/w mannitol, sodium hydroxide to a pH of 7.4 and purified water.
• Another preferred emulsion of the present invention 0.5% w/w polysorbate 80, 1.0% w/w glycerine, 1.25% w/w castor oil, 0.05% w/w pemulin TR-2, 1.0% w/w mannitol, sodium hydroxide to a pH of 7.4 and purified water.
• compositions for use in accelerating nail growth, treating brittle nails and strengthening nails in a human or animal comprising an oil-in-water emulsion topically applied to the fingernails or cuticles of a patient at least once a day.
• composition of paragraph 1 wherein the emulsion contains castor oil and a surfactant.
• composition of paragraphs 1 and 2 wherein the emulsion contains a cyclosporine A derivative or segment contains a cyclosporine A derivative or segment.
• composition of paragraphs 1-3 wherein the emulsion also contains one component selected from the group consisting of glycerin, polysorbate 80 and carbomer 1342.
• composition of paragraph 4 wherein the composition contains 1.0% w/v polysorbate 80, 2.2% w/v glycerine, 1.25% w/v castor oil, 0.05% w/v pemulin.
• composition of paragraphs 1-6 which is also useful for treating a disorder of the toenail or fingernail selected from the group consisting of nail psoriasis, psoriatic nail dystrophy, brittle nail syndrome, increasing nail length and thickness, onychia, onychiagryposis, onychia trophia, onychocryptosis, onychodystrophy, onychogryposis, onycholysis, onychomadesis, onychauxis, onychomycosis, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas, pterygium and pterygium inversum unguis, koilonychia, subungual hematoma or other trauma to the nail, folic acid deficiency, leukonychia, nail patella syndrome, melanonychia, protein deficiency, bri
• a method of accelerating nail growth, treating brittle nails and strengthening nails in a human or animal comprising:
• the oil is selected from the group consisting of: Anise oil; Castor oil; Clove oil; Cassia oil; Cinnamon oil; oils having a specific gravity between 0.90 and 0.95; Almond oil; Corn oil; Arachis oil; Cottonseed oil; Safflower oil; Maize oil; Linseed oil; Rapeseed oil; Soybean oil; Olive oil; Caraway oil; Rosemary oil; Peanut oil; Peppermint oil; Sunflower oil; Eucalyptus oil; Sesame oil; an oil having a specific gravity specific gravity below 0.9; Mineral oil; Coriander oil; Lavender oil; Citronella oil; Juniper oil; Lemon oil; Orange oil; Clary sage oil; Nutmeg oil; and, Tea tree oil.
• composition of paragraphs 8-12 wherein the oil-in-water emulsion further contains a surfactant selected from the group consisting of Polysorbate 80, carboxylated and ethoxylated alcohols, amine oxides, block polymers, fatty acids including carboxylic fatty acids, ethoxylated alkyl phenols, ethoxylated fatty esters, glycerol esters, lanolin-based derivatives, lignin derivatives, methyl esters, mono- and tri-glycerides, polyethylene glycols, polymeric surfactants, propoxylated and ethoxylated fatty acids, alcohols, or alkyl phenols, protein based surfactants, sucrose and glucose esters and derivatives.
• a surfactant selected from the group consisting of Polysorbate 80, carboxylated and ethoxylated alcohols, amine oxides, block polymers, fatty acids including carboxylic fatty acids, ethoxylated alkyl phenols,
• a medicament for the treatment of the following diseases selected from the group consisting of nail psoriasis, psoriatic nail dystrophy, onychia, onychiagryposis, onychia trophia, onychocryptosis, onychodystrophy, onychogryposis, onycholysis, onychomadesis, onychauxis, onychomycosis, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas, pterygium and pterygium inversum unguis, koilonychia, subungual hematoma or other trauma to the nail, folic acid deficiency, leukonychia, nail patella syndrome, melanonychia, protein deficiency, brittle and peeling nails, methyl methacrylate damaged nails, vitamin C de
• compositions for practicing the invention may be emulsions, colloids, suspensions, semi-solids, solutions, dispersions, capsules, gels, lotions, creams and the like.
• Active ingredients such as cyclosporine, retinoids (including but not limited to tazarotene), biotin, and silicone may optionally be included.
• cyclosporine components can be combined with carriers which form emulsions upon mixing with water.
• Such emulsions are described, for example, and without limitation, in Cavanak U.S. Pat. No. 4,388,307, the disclosure of which is hereby incorporated in its entirety by reference.
• compositions of the present invention are applied topically on the nail by an applicator and can be administered once or multiple times-a-day.
• emulsion formulations work to enhance or accelerate the growth of nails, including thickness and length, and cuticles and restore nails and cuticle to their natural health to thicken, strengthen and smooth the nail.
• compositions of the present invention may be used for treatment of disorders of the toenail and fingernail such as nail psoriasis, psoriatic nail dystrophy, brittle nail syndrome, increasing nail length and thickness, onychia, onychiagryposis, onychia trophia, onychocryptosis, onychodystrophy, onychogryposis, onycholysis, onychomadesis, onychauxis, onychomycosis, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas, pterygium and pterygium inversum unguis, koilonychia, subungual hematoma or other trauma to the nail, folic acid deficiency, leukonychia, nail patella syndrome, melanonychia, protein deficiency, brittle and peeling nails, methyl
• compositions will contribute to nail health to increase overall global nail health, increase nail strength, increase nail growth rate and thickness, decrease brittle nail syndrome, decrease weak nails, decrease nail pitting, decrease nail cracking, decrease nail splitting, decrease nail dullness, decrease nail roughness, (trachyonychia) decrease nail raggedness, decrease nail peeling, decrease nail fraying, decrease nails tendency to tear, decrease nail layering (lamellar onychoschizia), decrease Beau's lines, decrease onycohmadesis, decrease oncholysis, decrease onychorrhexis, decrease nail fragility, decrease nail paronychia, and decrease nail onychomycosis.
• the emulsions include hydrophobic components such as a pharmaceutically acceptable oil.
• the hydrophobic component may be present in an effective amount, for example, in an amount of up to about 0.01%-90% w/v but preferably from about 0.01-10% by w/v, 0.05%-5% w/v, 0.05%-2% w/v or 1.0%-1.5% by w/v.
• useful pharmaceutically acceptable oils include vegetable oils, animal oils, mineral oils, synthetic oils and the like and mixtures thereof.
• the hydrophobic component may comprise or consist of one or higher fatty acid glycerides.
• the hydrophobic component comprises or consists of castor oil.
• Surfactants may also be present in amounts of up to about 0.01-10% by w/v, 0.05%-5% w/v, 0.05%-2% w/v or 1.0%-1.5% by w/v.
• Surfactants may include alcohols including carboxylated and ethoxylated alcohols, amine oxides, block polymers, fatty acids including carboxylic fatty acids, ethoxylated alkyl phenols, ethoxylated fatty esters, glycerol esters, lanolin-based derivatives, lignin derivatives, methyl esters, mono- and tri-glycerides, polyethylene glycols, polymeric surfactants, propoxylated and ethoxylated fatty acids, alcohols, or alkyl phenols, protein based surfactants, sucrose and glucose esters and derivatives,
• the surfactant is a polysorbate and in particular polysorbate 80 but other surfactants may be used.
• Nonionic surfactants are preferred, and especially those surfactants having a hydrophile/lipophile balance (HLB) of 10 or more.
• HLB hydrophile/lipophile balance
• certain combinations of high- and low-HLB surfactants may be utilized; preferably, such mixed surfactants are used in ratio such that the aggregate surfactant HLB (when weighted according to proportions used) remains in excess of 10.
• surfactants include, but are not limited to, polyoxyethylene derivatives of natural or hydrogenated vegetable oils such as castor oil; polyoxyethylene-sorbitan fatty acid esters, such as mono-, di- and tri-lauryl, palmityl, stearyl and oleyl esters; alkyl/dialykyl sulfate, sulfonate or sulfosuccinate salts such as sodium lauryl sulfate and dioctyl sodium sulfosuccinate; polyoxyethylene fatty acid esters; phospholipids such as lecithins; transesterification products of natural vegetable oil triglycerides and polyalkylene polyols; sorbitan fatty acid esters; pentaerythritol fatty acid esters; polyoxyethylene glycol alkyl ethers and esters; and the like.
• the surfactants may be used alone or in combination.
• surfactants examples include, without limitation, polyoxyethylene castor oil derivatives, such as polyoxyethylene glycerol triricinoleate polyoxyl 35 castor oil (CREMOPHOR® EL, available from BASF Corporation), and polyoxyl 40 hydrogenated castor oil (CREMOPHOR® RH40, available from BASF Corporation); mono-fatty acid esters of poloxyethylene (20) sorbitan, such as polyoxyethylene (20) sorbitan monooleate (TWEEN® 80), polyoxyethylene (20) sorbitan monostearate (TWEEN® 60), polyoxyethylene (20) sorbitan monopalmitate (TWEEN® 40), and polyoxyethylene (20) sorbitan monolaurate (TWEEN® 20) (all available from ICI Surfactants, Wilmington, Del.); polyoxyethylene glycol 200 monostearate (MYRJ® 52, available from Calgene Chemicals, Skokie, Ill.); polyglycerol esters with a HLB of 10 or
• low-HLB auxiliary surfactants which may be used include, but are not limited to, polyglycerol oleates (such as CAPROL® 10G40); lecithins; glyceryl monooleate or monolinoleate mixtures (such as MYVEROL® 18-99 or 18-92); propylene glycol laurate; and sorbitan oleates such as sorbitan monooleate (SPAN® 80), sorbitan trioleate (SPAN® 85), and sorbitan sesquioleate (SPAN® 20) (all available from ICI Surfactants, Wilmington, Del.).
• the surfactant phase may comprise about 10% to 90% by weight of the composition.
• the surfactant comprises about 20% to about 70% of the composition, and more preferably about 40% to about 60%,
• compositions of the present invention may contain cyclosporine or other active compounds.
• Cyclosporines are a group of nonpolar cyclic oligopeptides with known immunosuppressant activity. Cyclosporine A, along with several other minor metabolites, as well as cyclosporine B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y and Z, have been identified.
• derivatives, salts and the like of such cyclosporines and a number of synthetic analogs have been prepared and may be useful in the present invention.
• cyclosporines may contain a mixture of several individual cyclosporines which all share a cyclic peptide structure consisting of eleven amino acid residues with a total molecular weight of about 1,200, but with different substituents or configurations of some of the amino acids.
• cyclosporine component as used herein is intended to include any individual member of the cyclosporine group, salts thereof, derivatives thereof, analogs thereof and mixtures thereof, as well as mixtures of two or more individual cyclosporines salts thereof, derivatives thereof, analogs thereof and mixtures thereof.
• Particularly preferred cyclosporine components include, without limitation, cyclosporine A, derivatives of cyclosporine A, salts of cyclosporine A and the like and mixtures thereof. Cyclosporine A is an especially useful cyclosporine component.
• cyclosporine As used herein the term “derivatives” of a cyclosporine refer to compounds having structures sufficiently similar to the cyclosporine so as to function in a manner substantially similar to or substantially identical to the cyclosporine, for example, cyclosporine A, in the present methods.
• cyclosporine A derivatives are those selected from ((R)-methylthio-Sar) 3 -(4′-hydroxy-MeLeu) cyclosporine A, ((R)-(Cyclo)alkylthio-Sar) 3 -(4′-hydroxy-MeLeu) 4 -cyclosporine A, and ((R)-(Cyclo)alkylthio-Sar) 3 -cyclosporine A derivatives described below.
• Me is methyl; Alk is 2-6C alkylene or 3-6C cycloalkylene; R is OH, COOH, alkoxycarbonyl, —NR 1 R 2 or N(R 3 )—(CH 2 )—NR 1 R 2 ; wherein R 1 , R 2 is H, alkyl, 3-6C cycloalkyl, phenyl (optionally substituted by halo, alkoxy, alkoxycarbonyl, amino, alkylamino or dialkylamino), benzyl or saturated or unsaturated heterocyclyl having 5 or 6 members and 1-3 heteroatoms; or NR 1 R 2 is a 5 or 6 membered heterocycle which may contain a further N, O or S heteroatom and may be alkylated; R 3 is H or alkyl and n is 2-4; and the alkyl moieties contain 1-4C.
• Oils which may be used in the compositions of the present invention, in particular emulsions, and which may be used in combinations of oils including two or more oils and in combination with surfactants, in combinations of two or more surfactants, include but are not limited to:
• Cinnamon oil Cinnamon oil
• Citronella oil
• Clary sage oil Clary sage oil
• Surfactants which may be used in the present invention in combination with one or more oils and in combination with one or more surfactants include, but are not limited to:
• Alcohols including but not limited to:
• Hetoxide GT-80® which is available from Global-Seven, Inc.;
• Lexemul BEO® which is available from Inolex Chemical Co.
• Polyglycerol-3® which is available from Solvay Chemicals, Inc.;
• Witconol H-31A® which is available from Akzo Nobel Surface Chemistry LLC.
• Amine Oxides including but not limited to,
• AO-405® which is available from Tomah Products®, Inc.
• AO-455® which is available from Tomah Products®, Inc.
• AO 728 Special® which is available from Tomah Products®, Inc.
• Barlox 12® which is available from Lonza Inc.
• Barlox 14® which is available from Lonza Inc.
• Burcoxide Lo® which is available from Burlington Chemical Co.®, Inc.;
• Chemoxide CAW® which is available from Chemron Corp.
• Chemoxide LO® which is available from Chemron Corp.
• Chemoxide MO® which is available from Chemron Corp.
• Colalux CAO-35® which is available from Colonial Chemical Co.
• Colalux LO® which is available from Colonial Chemical Co.
• DeMox CAPO® which is available from DeForest Enterprises, Inc.
• DeMox CSG-30® which is available from DeForest Enterprises, Inc.
• DeMox LAO® which is available from DeForest Enterprises, Inc.
• Emcol L® which is available from Crompton Corp.
• Foamox CDO® which is available from Alzo International, Inc.
• Foamox DMM® which is available from Alzo International, Inc.
• Foamox DMS® which is available from Alzo International, Inc.
• Genaminox KC® which is available from Clariant Corporation
• Genaminox LA® which is available from Clariant Corporation
• Hartofoam SAO® which is available from Hart Chemical Corp.
• Hartox DMCD® which is available from Hart Chemical Corp.
• Lipowax DAT® which is available from Lipo Chemicals, Inc.
• Lipowax PB Pastilles® which is available from Lipo Chemicals, Inc.
• Rhodamox LO® which is available from Rhodia, Inc.
• Tegotens DO® which is available from Goldschmidt Chemical Corp.
• Triaminox CDO® which is available from Tri-Tex Co.®, Inc.;
• Block Polymers including, but not limited to:
• Antarox 17-R-2® which is available from Rhodia, Inc.;
• Antarox 25-R-2® which is available from Rhodia, Inc.;
• Antarox 31-R-1® which is available from Rhodia, Inc.;
• Antarox P-84® which is available from Rhodia, Inc.;
• Antarox P-104/H® which is available from Rhodia, Inc.;
• Arnox BP-Series® which is available from Crompton Corp.
• Chemonic 435® which is available from Chemron Corp.
• Chemonic D-25® which is available from Chemron Corp.
• Chemonic PL Series® which is available from Chemron Corp.
• Ethox L-121® which is available from Ethox Chemicals, LLC;
• Ethox L-122® which is available from Ethox Chemicals, LLC;
• Genapol PF-10® which is available from Clariant Corporation
• Genapol PF-20® which is available from Clariant Corporation
• Genapol PF-40A® which is available from Clariant Corporation
• Norfox 2-LF® which is available from Norman, Fox & Co.
• T-Det BP-1® which is available from Harcros Chemicals Inc.
• T-Det XD® which is available from Harcros Chemicals Inc.
• T-Det XH® which is available from Harcros Chemicals Inc.
• Triton CF-32® which is available from Dow Chemical Company
• Witconol 171® which is available from Akzo Nobel Surface Chemistry LLC;
• Witconol 324® which is available from Akzo Nobel Surface Chemistry LLC;
• Witconol 324D® which is available from Akzo Nobel Surface Chemistry LLC;
• Witconol PD-2000® which is available from Akzo Nobel Surface Chemistry LLC;
• Carboxylated Alcohols or Alkylphenol Ethoxylates including but not limited to,
• Emcol CN-6® which is available from Crompton Corp.
• Ethcarb® which is available from Ethox Chemicals, LLC;
• Marlowet 4530 LF® which is available from Sasol North America Inc.
• Marlowet 4539 LF® which is available from Sasol North America Inc.
• Sandopan B® which is available from Clariant Corporation
• Sandopan B Modified® which is available from Clariant Corporation
• Sandopan LS-24 Gel® which is available from Clariant Corporation
• Carboxylic Acids/Fatty Acids including, but not limited to:
• Colaterge RAM® which is available from Colonial Chemical Co.
• Colatrope INC® which is available from Colonial Chemical Co.
• Crodacid B® which is available from Croda Inc.
• DeTrope CA-100® which is available from DeForest Enterprises, Inc.;
• Latol MTO® which is available from Georgia-Pacific Corp.
• Lumulse CC-33 K® which is available from Lambent Technologies Corp.
• Mulls 2218® which is available from Bernel Chemical Co.®, Inc.;
• R-910® which is available from Procter & Gamble
• Sandopan DTC Acid® which is available from Clariant Corporation
• Sandopan LS 24 N® which is available from Clariant Corporation.
• Sandopan MA-18® which is available from Clariant Corporation.
• Ethoxylated Alcohols including, but not limited to,
• Adsee 799® which is available from Crompton Corp.
• Alfonic 610-3.5® which is available from Sasol North America Inc.
• Alfonic 810-2® which is available from Sasol North America Inc.;
• Alfonic 810-6® which is available from Sasol North America Inc.;
• Alfonic 1012-3® which is available from Sasol North America Inc.;
• Alfonic 1012-5® which is available from Sasol North America Inc.;
• Alfonic 1216CO-1.5® which is available from Sasol North America Inc.;
• Alfonic 1216CO-7® which is available from Sasol North America Inc.
• Alfonic 1412-3® which is available from Sasol North America Inc.;
• Alfonic 1412-7® which is available from Sasol North America Inc.;
• Arlasolve 200® which is available from Uniqema
• Arlasolve 200 Liquid® which is available from Uniqema
• Bio Soft E-200® which is available from Stepan Canada Inc.;
• Bio Soft E-300® which is available from Stepan Canada Inc.;
• Bio Soft E-400® which is available from Stepan Canada Inc.;
• Bio Soft EN 600® which is available from Stepan Canada Inc.
• Bio Soft TD-400® which is available from Stepan Canada Inc.
• Bio Soft TD-630® which is available from Stepan Canada Inc.
• Burcoterge CDG® which is available from Burlington Chemical Co.®, Inc.;
• Canasol AT 600® which is available from Canamex Quimicos S.A de C.v;
• Canasol AT 800® which is available from Canamex Quimicos S.A de C.v;
• Canasol AT 1200® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 35® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 36® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 52® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 58® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 72® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 78® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 98® which is available from Canamex Quimicos S.A de C.v;
• Canasol BJ 307® which is available from Canamex Quimicos S.A de C.v;
• Cetomacrogol 1000 BP® which is available from Croda Inc.
• Chemonic C-2® which is available from Chemron Corp.
• Chemonic C-10® which is available from Chemron Corp.
• Chemonic C-20® which is available from Chemron Corp.
• Chemonic CT-12® which is available from Chemron Corp.
• Chemonic CT-20® which is available from Chemron Corp.
• Chemonic CT-30® which is available from Chemron Corp.
• Chemonic CT-55® which is available from Chemron Corp.
• Chemonic G-7® which is available from Chemron Corp.
• Chemonic G-26® which is available from Chemron Corp.
• Chemonic L-4® which is available from Chemron Corp.
• Chemonic L-7® which is available from Chemron Corp.
• Chemonic L-12® which is available from Chemron Corp.
• Chemonic L-23® which is available from Chemron Corp.
• Chemonic O-2® which is available from Chemron Corp.
• Chemonic O-5® which is available from Chemron Corp.
• Chemonic O-10® which is available from Chemron Corp.
• Chemonic O-20® which is available from Chemron Corp.
• Chemonic S-2® which is available from Chemron Corp.
• Chemonic S-10® which is available from Chemron Corp.
• Chemonic S-20® which is available from Chemron Corp.
• Colamulse FE® which is available from Colonial Chemical Co.
• Cremophor A 20® which is available from BASF Corp.
• Cremophor SA 2® which is available from BASF Corp.
• DeThox LA-4® which is available from DeForest Enterprises, Inc.
• DeThox LA-23® which is available from DeForest Enterprises, Inc.;
• DeThox SA-80® which is available from DeForest Enterprises, Inc.
• Disponil O5® which is available from Cognis Corporation
• Eccoterge EO-41B® which is available from Eastern Color & Chemical Co.
• Ethylan 1204® which is available from Akzo Nobel Surface Chemistry LLC;
• Eumulgin B1® which is available from Cognis Canada Corp.;
• Eumulgin B2® which is available from Cognis Canada Corp.;
• Eumulgin B3® which is available from Cognis Canada Corp.
• Eumulgin O-10® which is available from Cognis Canada Corp.
• Flo Mo Low Foam® which is available from Crompton Corp.
• Genapol 1454® which is available from Clariant Corporation
• Genapol BA-020® which is available from Clariant Corporation;
• Genapol BA-040® which is available from Clariant Corporation;
• Genapol C-100® which is available from Clariant Corporation;
• Genapol DA 060® which is available from Clariant Corporation
• Genapol HS 020® which is available from Clariant Corporation
• Genapol HS 200® which is available from Clariant Corporation
• Genapol ID-040® which is available from Clariant Corporation
• Genapol ID-060® which is available from Clariant Corporation
• Genapol ID-090® which is available from Clariant Corporation
• Genapol LA 010® which is available from Clariant Corporation;
• Genapol LA 020® which is available from Clariant Corporation;
• Genapol LA 030® which is available from Clariant Corporation
• Genapol LA 040® which is available from Clariant Corporation;
• Genapol LA 050® which is available from Clariant Corporation
• Genapol LA 060® which is available from Clariant Corporation;
• Genapol LA 070® which is available from Clariant Corporation;
• Genapol LA 0705® which is available from Clariant Corporation;
• Genapol LA 230® which is available from Clariant Corporation
• Genapol O 020® which is available from Clariant Corporation
• Genapol O 050® which is available from Clariant Corporation
• Genapol O 100® which is available from Clariant Corporation
• Genapol O 200® which is available from Clariant Corporation
• Genapol SA 030® which is available from Clariant Corporation
• Genapol SA 120® which is available from Clariant Corporation
• Genapol T-020® which is available from Clariant Corporation;
• Genapol UD-030® which is available from Clariant Corporation
• Genapol UD-050® which is available from Clariant Corporation
• Genapol UD-070® which is available from Clariant Corporation
• Genapol UD-079® which is available from Clariant Corporation
• Genapol UD-080® which is available from Clariant Corporation
• Genapol UD-110® which is available from Clariant Corporation
• Genapol X 030® which is available from Clariant Corporation
• Genapol X 050® which is available from Clariant Corporation
• Genapol X 060® which is available from Clariant Corporation
• Genapol X 070® which is available from Clariant Corporation
• Genapol X 080® which is available from Clariant Corporation
• Genapol X 100® which is available from Clariant Corporation
• Genapol X159® which is available from Clariant Corporation
• Iconol LF 110® which is available from BASF Corp.
• Lexemul CS-20® which is available from Inolex Chemical Co.
• Liponic EG-1® which is available from Lipo Chemicals, Inc.
• Lipowax D® which is available from Lipo Chemicals, Inc.
• Lipowax G® which is available from Lipo Chemicals, Inc.
• Lipowax NI® which is available from Lipo Chemicals, Inc.
• Lipowax P® which is available from Lipo Chemicals, Inc.
• Lipowax P-31® which is available from Lipo Chemicals, Inc.
• Lipowax PR® which is available from Lipo Chemicals, Inc.
• Lumulse CS-20® which is available from Lambent Technologies Corp.
• Macol CSA-20® which is available from BASF Corp.
• Norfox 1713® which is available from Norman, Fox & Co.;
• Norfox 2579® which is available from Norman, Fox & Co.;
• Promulgen D® which is available from Amerchol Corp.
• Promulgen G® which is available from Amerchol Corp.
• Renex 30® which is available from Uniqema
• Renex 36® which is available from Uniqema
• Rhodasurf A 24® which is available from Rhodia, Inc.
• Rhodasurf AAE-10® which is available from Rhodia, Inc.
• Rhodasurf BEH-25® which is available from Rhodia, Inc.
• Rhodasurf BEH-40® which is available from Rhodia, Inc.
• Rhodasurf DA 530® which is available from Rhodia, Inc.
• Rhodasurf DA 630® which is available from Rhodia, Inc.
• Rhodasurf DA 639® which is available from Rhodia, Inc.
• Rhodasurf LAN-23® which is available from Rhodia, Inc.
• Rhodasurf ON-870® which is available from Rhodia, Inc.
• Rhodasurf ON-877® which is available from Rhodia, Inc.
• Rhodasurf TB-970 FLK® which is available from Rhodia, Inc.
• Synthrapol KB® which is available from Uniqema
• Teginacid® which is available from Goldschmidt Chemical Corp.
• Teginacid C® which is available from Goldschmidt Chemical Corp.
• Tinegal NA® which is available from Ciba Specialty Chemicals Corp.
• Tomadol 400® which is available from Tomah Products®, Inc.;
• Tomadol 600® which is available from Tomah Products®, Inc.;
• Tomadol 900® which is available from Tomah Products®, Inc.;
• Witconol SN Series® which is available from Crompton Corp.
• Rhodasurf LAN-23® Rhodasurf LAN-23®
• Ethoxylated Alkylphenols including, but not limited to:
• Antarox LF-222® which is available from Rhodia, Inc.
• Atlox 775® which is available from Uniqema
• Canasol NF-1000® which is available from Canamex Quimicos S.A de C.v;
• Canasol NF-3000® which is available from Canamex Quimicos S.A de C.v;
• Canasol NF-3070® which is available from Canamex Quimicos S.A de C.v;
• Canasol OF 1670® which is available from Canamex Quimicos S.A de C.v;
• Canasol OF 2570® which is available from Canamex Quimicos S.A de C.v;
• Canasol OF 4070® which is available from Canamex Quimicos S.A de C.v;
• Chemax DNP-8® which is available from Chemax Performance Solutions
• Chemax DNP-18® which is available from Chemax Performance Solutions
• Chemax DNP-150/50® which is available from Chemax Performance Solutions
• Eccoscour RC® which is available from Eastern Color & Chemical Co.
• Eccoterge EO-100® which is available from Eastern Color & Chemical Co.
• Emulsifier 632/90%® which is available from Ethox Chemicals, LLC;
• Geronol AG-821® which is available from Rhodia, Inc.
• Hetoxide NP-4® which is available from Global-Seven, Inc.;
• Hetoxide NP-30® which is available from Global-Seven, Inc.;
• Hostapal N-110® which is available from Clariant Corporation
• Igepal CTA-639W® which is available from Rhodia, Inc.
• Igepal DAP-9® which is available from Rhodia, Inc.
• Igepal OD-410® which is available from Rhodia, Inc.
• Igepal SS-837® which is available from Rhodia, Inc.
• Lipocol NP-9 USP® which is available from Lipo Chemicals, Inc.
• Triton N-57® which is available from Dow Chemical Company
• Trycol 6956® which is available from Cognis Corporation
• Trycol 6961® which is available from Cognis Corporation
• Trycol 6964® which is available from Cognis Corporation
• Trycol 6969® which is available from Cognis Corporation
• Trycol 6974® which is available from Cognis Corporation
• Witbreak DRB-127® which is available from Akzo Nobel Surface Chemistry LLC;
• Witbreak DRB-127® which is available from Crompton Corp.
• Witconol NP Series® which is available from Akzo Nobel Surface Chemistry LLC;
• Triton X-100® Triton X-100®
• Triton X-102® Triton X-102®
• Triton X-114® Triton X-114®
• Triton X-15® Triton X-15®
• Triton X-207® Triton X-207®
• Triton X-35® Triton X-35®
• Soprophor BSU® which is available from Rhodia, Inc.
• Soprophor CY/8® which is available from Rhodia, Inc.
• Soprophor S/25® which is available from Rhodia, Inc.;
• Witconol NIO® which is available from Akzo Nobel Surface Chemistry LLC;
• Witconol NIW® which is available from Akzo Nobel Surface Chemistry LLC;
• Witconol S-100® which is available from Akzo Nobel Surface Chemistry LLC;
• Ethoxylated Fatty Acids including, but not limited to:
• Crystal Inhibitor No. 5® which is available from Harcros Chemicals Inc.;
• DeThox Acid L-9® which is available from DeForest Enterprises, Inc.;
• DeThox Acid S-8® which is available from DeForest Enterprises, Inc.;
• Ethofat 242/25® which is available from Akzo Nobel Surface Chemistry LLC;
• Hydropalat 65® which is available from Cognis Corporation
• Lipo EGMS® which is available from Lipo Chemicals, Inc.
• Lipopeg 2 DL® which is available from Lipo Chemicals, Inc.;
• Lipopeg 4 DL® which is available from Lipo Chemicals, Inc.;
• Lipopeg 4-L® which is available from Lipo Chemicals, Inc.;
• Lipopeg 39-S® which is available from Lipo Chemicals, Inc.;
• Lipopeg 4-S® which is available from Lipo Chemicals, Inc.
• Lipopeg 10-S® which is available from Lipo Chemicals, Inc.;
• Lipopeg 100-S® which is available from Lipo Chemicals, Inc.;
• Lipopeg 6000 DS® which is available from Lipo Chemicals, Inc.
• Lumulse 40-L® which is available from Lambent Technologies Corp.
• Lumulse 40-S® which is available from Lambent Technologies Corp.
• Lumulse 42-L® which is available from Lambent Technologies Corp.
• Lumulse 42-S® which is available from Lambent Technologies Corp.
• Lumulse 100-S® which is available from Lambent Technologies Corp.
• Lumulse 602-S® which is available from Lambent Technologies Corp.
• Magrabar PGE-20-0® which is available from Magrabar Chemical Corp.
• Magrabar PGE-40-0® which is available from Magrabar Chemical Corp.
• Magrabar PGE-60-0® which is available from Magrabar Chemical Corp.
• Magrabar PGE-62-0® which is available from Magrabar Chemical Corp.
• Mapeg S-40K® which is available from BASF Corp.
• Renex 20® which is available from Uniqema
• Tego Acid S 40 P® which is available from Goldschmidt Chemical Corp.
• Tego Acid S 100 P® which is available from Goldschmidt Chemical Corp.
• Tween 20® which is available from Uniqema

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Epidemiology (AREA)
• Organic Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• General Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Immunology (AREA)
• Proteomics, Peptides & Aminoacids (AREA)
• Gastroenterology & Hepatology (AREA)
• Dermatology (AREA)
• Birds (AREA)
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• Dispersion Chemistry (AREA)
• Medicinal Preparation (AREA)
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• 2010
  • 2010-01-07 EA EA201190088A patent/EA201190088A1/ru unknown
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  • 2010-01-07 KR KR1020117018459A patent/KR20110125636A/ko not_active Application Discontinuation
  • 2010-01-07 SG SG2011049517A patent/SG172894A1/en unknown
  • 2010-01-07 CN CN201080010931XA patent/CN102341116A/zh active Pending
  • 2010-01-07 KR KR1020117018462A patent/KR20110123739A/ko not_active Application Discontinuation
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  • 2010-01-07 AU AU2010203607A patent/AU2010203607A1/en not_active Abandoned
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  • 2010-01-07 WO PCT/US2010/020378 patent/WO2010080915A1/en active Application Filing
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• 2013
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