US20100076370A1 - Apparatus and methods for purging catheter systems - Google Patents

Apparatus and methods for purging catheter systems Download PDF

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Publication number
US20100076370A1
US20100076370A1 US12/387,937 US38793709A US2010076370A1 US 20100076370 A1 US20100076370 A1 US 20100076370A1 US 38793709 A US38793709 A US 38793709A US 2010076370 A1 US2010076370 A1 US 2010076370A1
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US
United States
Prior art keywords
pressure
plunger
valve
fluid
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/387,937
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English (en)
Inventor
Michael W. Howlett
James V. Mercer
Amelio Paolucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INFUSTION ADVANCEMENTS LLC
Becton Dickinson and Co
Original Assignee
Infusion Advancements LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infusion Advancements LLC filed Critical Infusion Advancements LLC
Priority to US12/387,937 priority Critical patent/US20100076370A1/en
Assigned to INFUSTION ADVANCEMENTS, LLC reassignment INFUSTION ADVANCEMENTS, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HOWLETT, MICHAEL W., MERCER, JAMES V., PAOLUCCI, AMELIO
Publication of US20100076370A1 publication Critical patent/US20100076370A1/en
Assigned to BECTON, DICKINSON AND COMPANY reassignment BECTON, DICKINSON AND COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: INFUSION ADVANCEMENTS LLC
Priority to SG10201401706RA priority patent/SG10201401706RA/en
Priority to KR1020117029408A priority patent/KR101722281B1/ko
Priority to PCT/US2010/033999 priority patent/WO2010132290A2/en
Priority to KR1020187005262A priority patent/KR101921875B1/ko
Priority to CN201080027044.3A priority patent/CN102458510B/zh
Priority to BRPI1011379A priority patent/BRPI1011379B8/pt
Priority to ES10717454T priority patent/ES2763939T3/es
Priority to KR1020177007989A priority patent/KR101834705B1/ko
Priority to CA2761244A priority patent/CA2761244C/en
Priority to JP2012510873A priority patent/JP5661747B2/ja
Priority to CA3009388A priority patent/CA3009388C/en
Priority to CN201410610252.6A priority patent/CN104368074B/zh
Priority to CN201811021827.5A priority patent/CN109045440B/zh
Priority to MX2011011840A priority patent/MX2011011840A/es
Priority to CN202110899563.9A priority patent/CN113577441B/zh
Priority to BR122020014294-4A priority patent/BR122020014294B1/pt
Priority to SG2011082161A priority patent/SG175949A1/en
Priority to EP10717454.2A priority patent/EP2427232B1/en
Priority to KR1020187033283A priority patent/KR102000900B1/ko
Priority to AU2010247969A priority patent/AU2010247969B2/en
Priority to TW108117187A priority patent/TW201945042A/zh
Priority to TW105134597A priority patent/TWI679042B/zh
Priority to TW099114890A priority patent/TWI569838B/zh
Priority to NO20111706A priority patent/NO347774B1/no
Priority to JP2014245301A priority patent/JP6472990B2/ja
Priority to US14/797,782 priority patent/US9889289B2/en
Priority to AU2016200737A priority patent/AU2016200737B2/en
Priority to PH12017500871A priority patent/PH12017500871B1/en
Priority to JP2017129486A priority patent/JP6652526B2/ja
Priority to AU2018200153A priority patent/AU2018200153B2/en
Priority to US15/894,477 priority patent/US10561796B2/en
Priority to US16/739,893 priority patent/US11266790B2/en
Priority to JP2020009228A priority patent/JP6906643B2/ja
Priority to US17/584,692 priority patent/US11964139B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/1424—Manually operated pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1403—Flushing or purging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0019—Cleaning catheters or the like, e.g. for reuse of the device, for avoiding replacement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A61M2039/242—Check- or non-return valves designed to open when a predetermined pressure or flow rate has been reached, e.g. check valve actuated by fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/225—Flush valves, i.e. bypass valves for flushing line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston

Definitions

  • This invention is associated with apparatus and methods for clearing catheter systems (e.g. IV lines) by creating controlled and consistent turbulent flushing pressure and flow within the system to purge the line of unwanted residue, and, in particular, the invention is associated with apparatus and methods for creating such turbulent flushing pressure and flow substantially independent of clinician technique.
  • catheter systems e.g. IV lines
  • the invention is associated with apparatus and methods for creating such turbulent flushing pressure and flow substantially independent of clinician technique.
  • Push-pause (or turbulent) flushing simply requires a clinician to alternately increase and decrease an associated infusion rate during flushing.
  • efficiency and success of catheter purging using push-pause flushing is well known to be completely dependent upon individual awareness, compliance and technique and a successful purging operation is often incomplete and problematic. For this reason, many users may not use such turbulent flushing effectively while others, due to lack of knowledge or perception of value, may not use it at all.
  • syringes, pumps and other fluid forcing mechanisms associated with IV infusion are substantially operated in a laminar flow domain.
  • pressure and flow characteristics are constrained well below those turbulent and volumetric flow levels required for effective catheter purging.
  • stops are employed to aid in accurately measuring and dispensing a portion of a syringe fill. Once such stops are reached, it is common for the plunger to be released to thereby permit controlled and substantially laminar flow to the next stop. In other words, such stops are generally released without a calculated, intentional force to propel the stopper with sufficient force for catheter purging.
  • Other stops are commonly used to limit a syringe to a single use. Generally, these stops are hard and cannot be reasonably overcome, as is common in single-use hypodermic syringes.
  • U.S. Pat. No. 5,318,544 issued Jun. 7, 1994 to John Drypen, et al. discloses a metering syringe having a plunger rod containing a plurality of stop surfaces. The stop surfaces are spaced apart to define a predetermined dose volume. Plunger rod rotation relieves each stop to permit further dispensing.
  • U.S. Pat. No. 5,059,181 issued Oct. 22, 1991 to Robert B. Agran also discloses a syringe assembly having recesses in a plunger rod which are used to retard a second rearward displacement of the plunger rod associated with a second use of the syringe assembly.
  • U.S. Pat. No. 5,084,017 issued Jan. 28, 1992 to John Maffetone discloses a single use syringe having a notched plunger rod. The syringe of Maffatone is taught to operate smoothly, but to dissemble itself at the completion of a single use cycle.
  • U.S. Pat. No. 5,328,476 issued Jul. 12, 1994 to James Bidwell discloses a single-use hypodermic syringe apparatus. Rachet grooves in an associated plunger rod are used as lock members such that when plunger is fully inserted or reinserted into a casing, the plunger is prevented from being withdrawn relative to the casing.
  • U.S. Pat. No. 6,488,651 issued Dec. 3, 2002 to David Paul Morris et al. discloses a mixing syringe having a plunger rod dasher which permits flow within the barrel for communicating material to be mixed with material in a more proximal chamber.
  • Other cylindrical barriers provide within chamber defining spaces which are selectively displaced by movement of the plunger rod.
  • resistances of fluid dynamics and friction (and stiction) no other retarding forces are taught.
  • U.S. Pat. No. 5,685,864 issued Nov. 11, 1997 to Laurence M. Shanley, et al. discloses an aspiration syringe device which operates oppositely to aspirate rather than discharge into a connected site.
  • a right angle stem of an associated plunger is equipped with spaced flanges.
  • Interior of the syringe barrel is equipped with at least one stop. When a flange is contiguous with a stop, advancement of the plunger is prohibited. Rotation of the plunger permits further advancement.
  • this novel invention alleviates all of the known problems related to generating controlled and predetermined push-pause pressures and flows thereby providing controlled and consistent turbulent flow which is effective in purging matter disposed within a catheter system.
  • the invention comprises methods and apparatus which are defined and designed to produce pressures resulting from dynamic releases by predetermined forces, each for a period which provides a controlled and consistent surge to effectively produce turbulent purging fluid flow at a site of concern within a catheter system.
  • such flow is provided to a catheter system from a source of flush liquid from a container sized to hold a volume of liquid consistent with flow volume requirements of a desired pressure pulse.
  • an actuator opens a valve mechanism at a predetermined pressure to initiate the desired liquid pulse pressure and resulting liquid flow.
  • the sensing actuator has an operating hysteresis which ultimately stops flow to end the pressure pulse.
  • an implement which, by example, may be a pump or piston, is a crucial part of the apparatus for providing sufficient pressure to activate the valve mechanism.
  • a memory element provides a source of stored energy received from the implement and releases the stored energy upon valve mechanism opening to retain the turbulent flushing fluid pressure and flow for a desired pulse period.
  • One embodiment of the apparatus is application of the invention to a syringe, and more specifically, to a plunger rod of a syringe.
  • the barrel of a syringe is the container. Displacement of the plunger rod (and associated plunger) within the barrel acts as an implement to dispense liquid from the syringe.
  • a retention ring formed of reduced diameter relative to the diameter of the rest of the syringe barrel.
  • This retention ring is used as a tactile indicator between an entry disk disposed on the stem of a plunger rod just proximal from the plunger affixed to the plunger rod, providing an impedance which must be overcome to extract the plunger rod (and plunger) from the syringe barrel.
  • At least one actuating geometry sized and shaped to require a predetermined force to displace the actuating geometry past the retention ring, is disposed proximally on the stem relative to the entry disk. Forcing the actuating geometry past the retention ring yields the force necessary to provide desired turbulent flushing fluid pressure and initiate flow.
  • Such geometry may be a disk on the plunger or an interfacing nub on exterior edges of shafts of a plunger rod. Reflexive motion associated with forcing the actuating disk past the retention disk provides the memory based, stored energy necessary to assure continuation of forced flow thereby providing the pressure pulse.
  • the length of the pressure pulse is determined by either the plunger being displaced to empty the syringe barrel or a second actuating disk disposed proximally on the stem relative to the actuating disk just forced through the retention ring to provide a tactilely determinable stop. Note, that resistance of this stop, relative to reflexive energy applied to displace the syringe plunger rod, provides the hysteresis specified.
  • a conventional syringe barrel in combination with a plunger rod made according to specifications of the instant invention, can provide desired pulse-pause pressure pulses from a syringe substantially independent of a syringe user. It may be preferred to provide a segment of a plunger rod free of actuating geometry to provide a “no-pulse” segment to enable conventional flush technique to check for possible occlusions and to verify blood return.
  • the pulse-pause pressure pulse is provided by an in-line apparatus.
  • Source for fluid is from a receptacle having sufficient volume to fill a container from which the pressure pulse is generated, the container being a hollow cylindrical vessel which receives liquid from the receptacle through a one-way valve.
  • Communication for dispensing liquid to the catheter system is through another one-way valve.
  • the valve mechanism is a plunger, sized and shaped to displace fluid within the vessel through the one-way valve to the catheter system.
  • the vessel has a retention ring similar to the retention ring of the barrel of a conventional syringe.
  • a valve-actuating disk associated with the plunger is sized and shaped to require predetermined force necessary to generate a desired pulse toward the catheter system. Volume of the vessel determines pulse volume.
  • reflexive action resulting from release of force when the actuating disk is driven past the retention ring assures adequate pulse pressure.
  • the actual implement for driving the plunger is derived from a button affixed to the plunger and associated rod whereby the plunger is manually driven through the vessel.
  • a spring disposed to be compressed when the pressure pulse is generated stores energy to return the plunger and refill the vessel for a subsequent pulse-pause cycle.
  • a pressure sensitive switch having an actuator which opens the valve at a higher predetermined pressure and closes at a lower predetermined pressure.
  • the source is a fluid receptacle upstream from a pressure-providing device which provides fluid dispensed at a predetermined pressure and flow.
  • a vessel acts as a container which communicates with the pressure providing device through a flow restrictor. Further, the vessel communicates with the catheter system through the pressure sensitive valve.
  • the pressure sensitive valve is selected to have an opening pressure which provides a fluid pulse having desired turbulent flow characteristics and closing at a pressure after a desire flow volume has been achieved and pressure within the vessel is reduced below the lower predetermined pressure.
  • a pump provides pressure of the source.
  • a spring loaded piston chamber provides opportunity to gather volume for the pressure pulse which fills at a pressure lower than the higher predetermined pressure through a flow restrictor affixed to the output of the pump, but at a pressure higher than the lower predetermined pressure. Thus, the higher predetermined pressure is reached only upon filling the chamber.
  • the valve is opened by the actuator to initiate the controlled pressure pulse.
  • pressure in the vessel drops below the lower predetermined pressure and the actuator closes the valve. If this embodiment remains affixed to the catheter system a subsequent pressure pulse is generated automatically.
  • a squeezable tube In this case the tube communicates with the catheter system through a pressure sensitive valve, having valve actuator opening characteristics as disclosed supra. Upstream the tube communicates with the source through a one-way valve. Pressure from the source does not reach or exceed the higher predetermined pressure, but is sufficient to fill the tube. Thus, pressure from the upstream source and elastic memory in the tube cause the tube to fill through the upstream one-way valve. Once the tube is adequately filled, it is selectively squeezed to cause the pressure to rise to at least the higher predetermined pressure. Once pressure within the tube is at or above the higher predetermined pressure, the valve is opened and the pressure pulse is initiated. The pressure pulse is continued by reflexive action following valve opening. Expulsion of liquid from the tube ultimately results in valve closing ending the pressure pulse. The pressure pulse may be continued until the tube is substantially empty.
  • Methods for using embodiments of the instant invention generally involve filling a chamber or vessel, of predetermined size, from which a pulse of liquid is to be dispensed, causing pressure within the chamber or vessel to exceed a predetermined pressure and selectively opening a pathway to the catheter system only when that pressure is achieved. In that manner, a desired, controlled pulse-pause pressure pulse is achieved and provided substantially independent of performance of a user.
  • FIG. 1 is a perspective of a syringe and plunger rod made according to the present invention where stem of the plunger rod has a plurality of disks disposed upon the length thereof.
  • FIG. 2 is a cross section of the syringe and plunger rod and seen in FIG. 1 .
  • FIG. 2A is a cross section of a syringe and plunger rod which is similar to the syringe and plunger rod of FIG. 2 , but wherein edges of disks are shaped to facilitate displacing the plunger rod into the syringe and deterring the plunger rod from being removed from the barrel, once so displaced.
  • FIG. 2B is a cross section of a syringe and plunger rod which is similar to the syringe and plunger rod of FIG. 2 , but wherein edges of disks are shaped to facilitate displacing the plunger rod out of the syringe once displaced therein.
  • FIG. 2C is a cross section of a syringe and plunger rod which is similar to syringes and plunger rods of FIGS. 2 , 2 A and 2 B, but having nubs along a shaft of a plunger rod instead of disks.
  • FIG. 3 is a perspective of the plunger rod seen in FIG. 1 .
  • FIG. 4 is a perspective of a syringe and plunger rod wherein the plunger rod is similar to the plunger rod of FIG. 1 but fabricated with a plurality of breakaway rings disposed about to stem of the plunger rod.
  • FIG. 5 is a perspective of the plunger rod seen in FIG. 4 .
  • FIG. 6 is a perspective of the syringe and plunger rod seen in FIG. 4 with at least one breakaway ring sheered from the stem of the plunger rod.
  • FIG. 7 is a perspective of a syringe and plunger rod wherein the plunger rod is similar to the plunger rod of FIG. 1 but having a pattern of undulations on the stem and a constraining elastomeric ring about the proximal syringe barrel opening.
  • FIG. 8 is a cross section of the syringe, plunger rod and elastomeric ring seen in FIG. 7 .
  • FIG. 9 is a perspective of an automatic, in-line pulsing device made according to the present invention.
  • FIG. 10 is a cross section of the automatic, in-line pulsing device seen in FIG. 9 showing state of the device at the end of a pulse.
  • FIG. 11 is a cross section of the automatic pulsing device seen in FIG. 9 showing state of the device when charged before actuating a pulse.
  • FIG. 12 is a cross section of the automatic pulsing device seen in FIG. 9 showing state of the device during pulse generation.
  • FIG. 13 is a perspective of the device seen in FIG. 9 with a syringe affixed to the device to provide a fluid pressure source.
  • FIG. 14 is a schematic drawing of a system which employs a pumped fluid source for the device seen in FIG. 9 .
  • FIG. 15 is a perspective of a squeezable device for providing a controlled pressure pulse according to the instant invention.
  • FIG. 16 is a cross section of the device seen in FIG. 15 .
  • FIG. 17 is a cross section of the device seen in FIG. 14 with a medical section squeezed at the end of a controlled release pressure pulse.
  • FIG. 18 is a perspective of a manually operated controlled pressure pulse device made according to the present invention.
  • FIG. 19 is a cross section of the device seen in FIG. 18 filled before initiating a controlled pressure pulse.
  • FIG. 20 is a cross section of the device seen in FIG. 18 at the end of a pressure pulse.
  • proximal is used to indicate the segment of the device normally closest to the object of the sentence describing its position.
  • distal refers to a site opposite the proximal section.
  • Combination 10 comprises a conventional syringe barrel 20 and a plunger rod 30 .
  • Salient features of combination 10 are better seen in FIG. 2 to comprise barrel 20 having a retention ring 40 disposed at proximal barrel hole opening 42 and plunger rod 30 comprising a plurality of actuating geometry, interfaces or rings, generally numbered 50 ) disposed along a stem 60 thereof.
  • plunger rod 30 has a plunger 70 affixed to the distal end 80 of stem 60 .
  • distal end 80 has a threaded geometry portion 90 which permits plunger rod 30 to be affixed to plunger 70 after barrel 20 is filled with liquid, generally referenced as liquid 72 .
  • a plunger rod 30 is seen alone in FIG. 3 providing a clearer view of threaded portion 90 .
  • plunger rod 30 has a first ring 92 which can be forced past retention ring 40 when plunger 70 and stem 60 are inserted into barrel 20 .
  • First ring 92 is sized and shaped to be forcible displaced through retention ring 40 , but provide a tactilely discernable stop such that plunger 70 is not inadvertently displaced out of barrel 20 .
  • Each actuator ring 50 is sized and shaped to be obstructed by retention ring 40 .
  • Each actuator ring 50 is further sized and shaped to require a predetermined force which must be exceeded to displace a contacting actuator geometry (e.g. retention ring interface 50 ) past retention ring 40 .
  • fluid within barrel 20 is displaced with resulting acceleration and velocity resulting from the predetermined force when the contacting ring 50 is releasibly displaced through retention ring 40 .
  • the resulting acceleration and velocity is of liquid which is discharged from syringe barrel 20 to turbulently flush liquid 72 through an associated catheter system. In this manner, each time a contacting ring 50 is displaced past retention ring 40 a pulse of pressurized liquid 72 is purged into the catheter system providing a turbulent flushing pulse of liquid 72 there through.
  • a more proximal ring 94 of rings 50 may be further shaped and sized to require a force which is greater than more distal rings 50 to provide a reminder that the pulse resulting from actuation using ring 94 is the last pulse provided by liquid 72 from combination 10 .
  • ring 94 may be referenced as reminder ring 94 hereafter. Note, that, if plunger rod 30 is not displaced sufficiently far into barrel 20 to displace reminder ring 94 past retention ring 40 , no back flow or reflux should occur in an associated catheter system.
  • proximal end 98 of stem 60 is convex or dome shaped to facilitate application of digital force against plunger rod 30 .
  • rings 50 are not necessarily spaced uniformly. As an example a space 99 between first ring 92 and next most proximal ring 50 is relatively large compared to space between other rings, generally numbered 50 . This provides for a “no-pulse” segment which may be used for conventional sampling for catheter blood flow to assure proper catheter operation.
  • FIG. 2A wherein a second combination 20 ′ of a conventional syringe barrel 20 and a plunger rod 30 ′ is seen.
  • Plunger rod 30 ′ is similar to plunger rod 30 , having a series of actuator rings 50 ′ disposed along the length thereof.
  • rings 50 ′ are shaped and sized (as seen in FIG. 2A ) to be more easily displaced into barrel 20 (and distally through retention ring 40 ) than displaced barrel 20 (proximally through retention ring).
  • Such meets a condition whereby plunger rod 30 ′ is not easily removed from barrel 20 , once used to promote a single use application.
  • actuating rings 50 ′′ disposed along a stem 60 are shaped as seen in FIG. 2B .
  • Rings 50 seen in FIG. 2 may be replaced by nubs 52 on a plunger rod 32 as seen as combination 12 in FIG. 2C .
  • Replacement of rings 50 by nubs 52 may be done without degradation of effect of producing desired turbulence by sizing and shaping nubs 52 to require forces similar to that required of rings 50 for displacement past retention ring 40 .
  • combination 110 comprises a conventional syringe barrel 20 .
  • syringe barrel 20 has a proximal entry hole 122 associated with retention ring 40 .
  • an associated plunger rod 30 also comprises a series of actuator rings, generally numbered 150 . disposed along a stem 60 of plunger rod 130 .
  • rings 150 are affixed to stem 60 in a manner which permits each actuation ring 150 to be sheared from stem 60 as it is displaced into barrel entry hole 42 .
  • Shear force at separate actuation rings 150 from stem 60 is geometrically and mechanically designed to provide a predetermined acceleration and velocity which purveys desired turbulent flow to purge and discharge unwanted contaminants from a downstream catheter system.
  • a first more distally disposed actuator ring 150 is seen to be captured by a second, more proximally disposed actuator ring 150 exterior to hole in FIG. 6 .
  • piling up of sheared actuation rings 150 may be used to prevent a syringe from being fully evacuated.
  • combination 210 which may use a conventional syringe barrel 20 , is seen in FIGS. 7 and 8 .
  • combination 210 comprises an elastomeric restrictor 230 a plunger rod 240 with a stem 242 .
  • Stem 242 comprises a plurality of elongated side members, each numbered 244 . Each side member has an undulating exterior edge, numbered 246 . High points of the undulations are generally numbered 248 .
  • Restrictor 230 is shaped and configured to provide a port about barrel entry hole 42 (see FIGS. 1 and 2 ).
  • a restrictor entry hole 250 is sized and shaped to obstruct inward displacement of plunger rod 240 upon collision between restrictor 230 and each high point 248 .
  • a combination of selected durometer of the elastomer of restrictor 230 , and collision geometry of high points 248 and hole 250 combine to require a predetermined force for further displacement of plunger rod 240 . This predetermined force is comparable to the force required for displacement of plunger rod 30 past retention ring 40 (see FIGS. 1-3 ). In this manner, a pressure pulse which provides turbulent flow for purging an attached catheter system is generated each time high points 248 are displaced through hole 250 of restrictor 230 .
  • device 310 comprises an upstream or proximal connection 320 , into which liquid from a liquid source is provided. Further device 310 comprises an output port and connector 330 which may be connected to a downstream catheter system. For proper operation, liquid pressure available from the source must be greater than desired pressure of a purging liquid pulse emitted by device 310 .
  • a pressure sensitive valve 340 is disposed to close output port and connector 330 when pressure is below the desired pressure.
  • a check valve 350 to obstruct backflow and retard inflow to a predetermined level of flow.
  • a pulse reservoir chamber 360 Disposed within chamber 360 is a piston 370 and spring 380 which acts within chamber 360 to store a volume of liquid when valve 330 is closed.
  • a valve should be selected which has an opening pressure to closing pressure hysteresis having a predetermined pressure differential for purposes clarified hereafter.
  • the pressure differential being defined as a difference between release high pressure and a low closing pressure.
  • the high pressure being a pressure which creates a pressure pulse having sufficient force and flow to cause down stream turbulence which purges a desired amount of material from an attached catheter system.
  • the lower pressure being a pressure to which pressure inside device 310 falls after clearing of liquid from chamber 360 . Note that, for pressure inside 310 to fall to the lower pressure, inflow from the source must be restricted to a lower flow rate than outflow through output port and connector 330 .
  • Steps of operation of device 310 are seen to embody a beginning state seen in FIG. 10 where chamber 360 is empty and spring 380 is decompressed and valve 350 is closed. Subsequent filling of chamber 360 is seen in FIG. 11 . Valve 340 is opened when spring 380 is fully compressed to discharge liquid from device 310 thereby. Of course, once valve 350 closes, the pulse cycle repeats.
  • Sources for pressurized fluid for device 310 are seen in FIGS. 13 and 14 .
  • a conventional syringe 390 is affixed to proximal connection 320 .
  • Source pressure is provided by the force displacing an associated plunger rod 392 . Note that sufficient pressure is required to fully charge chamber 360 before actuating valve 350 .
  • FIG. 14 a more sophisticated pressure providing source system is seen including a saline bag 304 , a pump 396 and a variable liquid flow restrictor 398 .
  • Source liquid from bag 394 is drawn and pumped by pump 396 to provide pressure equal to or greater than the high pressure necessary to open valve 350 .
  • Variable restrictor is set to determine pump 396 to device 310 liquid transfer rate to determine device 310 output pulse rate.
  • device 410 comprises an upstream or proximal connection 420 , into which liquid from a liquid source is provided. Further device 410 comprises an output port and connector 430 which may be connected to a downstream catheter system. For proper operation, liquid pressure available from the source must only be greater than filling pressure of an expandable tube 440 which is sized and shaped to be easily filled and purged by squeezing.
  • a pressure sensitive valve 340 (see also FIGS. 11-13 of device 310 , disclosed supra) is disposed to close output port and connector 430 when pressure is below a predetermined pressure. Just distal from proximal connection 420 is a check valve 450 to obstruct backflow. Tube 440 provides a storage medium which defines pulse flow quantity when device 410 is actuated. To operate, tube 440 is squeezed until valve 340 is opened to provide a pressure pulse according to the present invention. Continued reflexive squeezing dispenses liquid through valve 340 to create a plusatile flow of liquid having sufficient turbulent flow and pressure to purge an attached catheter system.
  • pressure of source liquid need only be at a sufficiently high pressure to fill tube 440 and that tube 440 may have sufficient inherent structural memory to provide a somewhat negative filling pressure requirement. This same memory reduces liquid pressure inside tube 440 to cause valve 340 to close at the end of a pulse generating cycle.
  • FIGS. 18-20 Another device 510 which provides manually, digitally generated controlled pressure pulses for purging catheter systems according to the present invention is seen in FIGS. 18-20 .
  • device 510 comprises an upstream or proximal connection 520 , into which liquid from a liquid source is provided. Further device 510 comprises an output port and connector 530 which may be connected to a downstream catheter system. For proper operation, liquid pressure available from the source must only be greater than filling pressure of a spring piston combination 540 .
  • Combination 540 comprises a depressible button and rod 550 , a compressible spring 560 and a plunger 570 .
  • Plunger 570 is sized and shaped to evacuate liquid from a hollow vertical chamber 580 which communicates orthogonally with a hollow liquid flow chamber 590 disposed for liquid communication between proximal connection 520 and output port 530 . Amount of liquid stored in vertical chamber 580 and released upon displacement of plunger 570 determines pulse volume of liquid delivered to the downstream catheter system.
  • a pressure sensitive valve 340 (see also FIGS. 11-13 of device 310 , disclosed supra) is disposed to close output port and connector 530 when pressure is below a predetermined pressure. Just distal from proximal connection 520 is a check valve 450 to obstruct backflow.
  • button 550 is depressed to open valve 340 thereby providing a pressure pulse according to the present invention. Continued reflexively depressing button 550 dispenses liquid through valve 340 to create a plusatile flow of liquid having sufficient turbulent flow and pressure to purge an attached catheter system.
  • pressure of source liquid need only be at a sufficiently high pressure to fill chamber 580 and that combination 540 with spring 560 should have sufficient inherent structural memory to provide a negative filling pressure inside chamber 590 . This same memory reduces liquid pressure inside chamber 590 to cause valve 340 to close at the end of a pulse generating cycle.
  • chamber 580 is permitted to fill with liquid provided through connector 520 .
  • Button 550 is depressed to provide sufficient force to open valve 340 and reflexively thereafter continued to be depressed until liquid is purged from chamber 580 as seen in FIG. 20 to produce the desired purging pressure pulse.
  • force on button 550 is relieved to permit refilling of chamber 580 for generating a subsequent pressure pulse.

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US12/387,937 2008-09-23 2009-05-09 Apparatus and methods for purging catheter systems Abandoned US20100076370A1 (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
US12/387,937 US20100076370A1 (en) 2008-09-23 2009-05-09 Apparatus and methods for purging catheter systems
KR1020187033283A KR102000900B1 (ko) 2009-05-09 2010-05-07 카테터 시스템을 퍼지하기 위한 장치
AU2010247969A AU2010247969B2 (en) 2009-05-09 2010-05-07 Apparatus for purging catheter systems
JP2012510873A JP5661747B2 (ja) 2009-05-09 2010-05-07 カテーテルシステムをパージするための装置および方法
BR122020014294-4A BR122020014294B1 (pt) 2009-05-09 2010-05-07 Haste de êmbolo e seringa de lavagem
EP10717454.2A EP2427232B1 (en) 2009-05-09 2010-05-07 Apparatus for purging catheter systems
PCT/US2010/033999 WO2010132290A2 (en) 2009-05-09 2010-05-07 Apparatus and methods for purging catheter systems
KR1020187005262A KR101921875B1 (ko) 2009-05-09 2010-05-07 카테터 시스템을 퍼지하기 위한 장치
CN201080027044.3A CN102458510B (zh) 2009-05-09 2010-05-07 清洗导管系统的装置
BRPI1011379A BRPI1011379B8 (pt) 2009-05-09 2010-05-07 aparelho que provê um fluxo pulsátil
ES10717454T ES2763939T3 (es) 2009-05-09 2010-05-07 Aparatos para purgar sistemas de catéter
KR1020177007989A KR101834705B1 (ko) 2009-05-09 2010-05-07 카테터 시스템을 퍼지하기 위한 장치
CA2761244A CA2761244C (en) 2009-05-09 2010-05-07 Apparatus and methods for purging catheter systems
KR1020117029408A KR101722281B1 (ko) 2009-05-09 2010-05-07 카테터 시스템을 퍼지하기 위한 장치
CA3009388A CA3009388C (en) 2009-05-09 2010-05-07 Apparatus and methods for purging catheter systems
CN201410610252.6A CN104368074B (zh) 2009-05-09 2010-05-07 清洗导管系统的装置和方法
CN201811021827.5A CN109045440B (zh) 2009-05-09 2010-05-07 冲洗注射器及其柱塞杆
MX2011011840A MX2011011840A (es) 2009-05-09 2010-05-07 Aparatos métodos para purgar los sistemas con catéteres.
CN202110899563.9A CN113577441B (zh) 2009-05-09 2010-05-07 冲洗注射器及其柱塞杆
SG10201401706RA SG10201401706RA (en) 2009-05-09 2010-05-07 Apparatus for purging catheter systems
SG2011082161A SG175949A1 (en) 2009-05-09 2010-05-07 Apparatus for purging catheter systems
TW108117187A TW201945042A (zh) 2009-05-09 2010-05-10 沖洗注射器
TW105134597A TWI679042B (zh) 2009-05-09 2010-05-10 沖洗注射器
TW099114890A TWI569838B (zh) 2009-05-09 2010-05-10 用以清洗導管系統之裝置與方法
NO20111706A NO347774B1 (no) 2009-05-09 2011-12-09 Apparat for å rense katetersystemer
JP2014245301A JP6472990B2 (ja) 2009-05-09 2014-12-03 カテーテルシステムをパージするための装置および方法
US14/797,782 US9889289B2 (en) 2008-09-23 2015-07-13 Apparatus and methods for purging catheter systems
AU2016200737A AU2016200737B2 (en) 2009-05-09 2016-02-05 Apparatus and methods for purging catheter systems
PH12017500871A PH12017500871B1 (en) 2009-05-09 2017-05-11 Apparatus for purging catheter systems
JP2017129486A JP6652526B2 (ja) 2009-05-09 2017-06-30 カテーテルシステムをパージするための装置および方法
AU2018200153A AU2018200153B2 (en) 2009-05-09 2018-01-08 Apparatus and methods for purging catheter systems
US15/894,477 US10561796B2 (en) 2008-09-23 2018-02-12 Apparatus and methods for purging catheter systems
US16/739,893 US11266790B2 (en) 2008-09-23 2020-01-10 Apparatus and methods for purging catheter systems
JP2020009228A JP6906643B2 (ja) 2009-05-09 2020-01-23 カテーテルシステムをパージするためのシリンジおよびそのプランジャロッド
US17/584,692 US11964139B2 (en) 2008-09-23 2022-01-26 Apparatus and methods for purging catheter systems

Applications Claiming Priority (2)

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US19282708P 2008-09-23 2008-09-23
US12/387,937 US20100076370A1 (en) 2008-09-23 2009-05-09 Apparatus and methods for purging catheter systems

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US14/797,782 Division US9889289B2 (en) 2008-09-23 2015-07-13 Apparatus and methods for purging catheter systems

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US20100076370A1 true US20100076370A1 (en) 2010-03-25

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US12/387,937 Abandoned US20100076370A1 (en) 2008-09-23 2009-05-09 Apparatus and methods for purging catheter systems
US14/797,782 Active US9889289B2 (en) 2008-09-23 2015-07-13 Apparatus and methods for purging catheter systems
US15/894,477 Active US10561796B2 (en) 2008-09-23 2018-02-12 Apparatus and methods for purging catheter systems
US16/739,893 Active 2029-11-16 US11266790B2 (en) 2008-09-23 2020-01-10 Apparatus and methods for purging catheter systems
US17/584,692 Active 2029-09-16 US11964139B2 (en) 2008-09-23 2022-01-26 Apparatus and methods for purging catheter systems

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US14/797,782 Active US9889289B2 (en) 2008-09-23 2015-07-13 Apparatus and methods for purging catheter systems
US15/894,477 Active US10561796B2 (en) 2008-09-23 2018-02-12 Apparatus and methods for purging catheter systems
US16/739,893 Active 2029-11-16 US11266790B2 (en) 2008-09-23 2020-01-10 Apparatus and methods for purging catheter systems
US17/584,692 Active 2029-09-16 US11964139B2 (en) 2008-09-23 2022-01-26 Apparatus and methods for purging catheter systems

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US (5) US20100076370A1 (enExample)
EP (1) EP2427232B1 (enExample)
JP (4) JP5661747B2 (enExample)
KR (4) KR101722281B1 (enExample)
CN (4) CN109045440B (enExample)
AU (3) AU2010247969B2 (enExample)
BR (2) BR122020014294B1 (enExample)
CA (2) CA2761244C (enExample)
ES (1) ES2763939T3 (enExample)
MX (1) MX2011011840A (enExample)
NO (1) NO347774B1 (enExample)
PH (1) PH12017500871B1 (enExample)
SG (2) SG175949A1 (enExample)
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