US20100025251A1 - System for automatically producing radioisotopes - Google Patents
System for automatically producing radioisotopes Download PDFInfo
- Publication number
- US20100025251A1 US20100025251A1 US11/919,509 US91950906A US2010025251A1 US 20100025251 A1 US20100025251 A1 US 20100025251A1 US 91950906 A US91950906 A US 91950906A US 2010025251 A1 US2010025251 A1 US 2010025251A1
- Authority
- US
- United States
- Prior art keywords
- unit
- target
- target carrier
- transfer means
- irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004070 electrodeposition Methods 0.000 claims abstract description 14
- 239000012535 impurity Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 7
- 230000001678 irradiating effect Effects 0.000 claims abstract description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 33
- 229910052751 metal Inorganic materials 0.000 claims description 17
- 239000002184 metal Substances 0.000 claims description 17
- 229910052697 platinum Inorganic materials 0.000 claims description 15
- 238000005868 electrolysis reaction Methods 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 238000005192 partition Methods 0.000 claims description 6
- 230000002285 radioactive effect Effects 0.000 claims description 5
- 229910052741 iridium Inorganic materials 0.000 claims description 3
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052758 niobium Inorganic materials 0.000 claims description 3
- 239000010955 niobium Substances 0.000 claims description 3
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 3
- 239000004411 aluminium Substances 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 19
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 16
- 239000002253 acid Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 229910052759 nickel Inorganic materials 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 239000008151 electrolyte solution Substances 0.000 description 6
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 229910017604 nitric acid Inorganic materials 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 2
- 239000000498 cooling water Substances 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- APFVFJFRJDLVQX-FTXFMUIASA-N indium-110 Chemical compound [110In] APFVFJFRJDLVQX-FTXFMUIASA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- JBNOVHJXQSHGRL-UHFFFAOYSA-N 7-amino-4-(trifluoromethyl)coumarin Chemical compound FC(F)(F)C1=CC(=O)OC2=CC(N)=CC=C21 JBNOVHJXQSHGRL-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- LGQLOGILCSXPEA-UHFFFAOYSA-L nickel sulfate Chemical compound [Ni+2].[O-]S([O-])(=O)=O LGQLOGILCSXPEA-UHFFFAOYSA-L 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25C—PROCESSES FOR THE ELECTROLYTIC PRODUCTION, RECOVERY OR REFINING OF METALS; APPARATUS THEREFOR
- C25C1/00—Electrolytic production, recovery or refining of metals by electrolysis of solutions
- C25C1/22—Electrolytic production, recovery or refining of metals by electrolysis of solutions of metals not provided for in groups C25C1/02 - C25C1/20
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25C—PROCESSES FOR THE ELECTROLYTIC PRODUCTION, RECOVERY OR REFINING OF METALS; APPARATUS THEREFOR
- C25C7/00—Constructional parts, or assemblies thereof, of cells; Servicing or operating of cells
- C25C7/007—Constructional parts, or assemblies thereof, of cells; Servicing or operating of cells of cells comprising at least a movable electrode
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
Definitions
- the present invention relates to a system for automatically producing radioisotopes.
- Radioisotopes have long been produced by cyclotron irradiation for medium- or low-energy (5-30 MeV) medical applications. Radioisotopes have many important industrial and scientific uses, the most important of which is as tracers: by reactions with appropriate non-radioactive precursors, radiodrugs are synthesized and, when administered in the human body, permit diagnosis and therapy monitoring by Positron Emission Tomography (PET), especially in the treatment of tumours.
- PET Positron Emission Tomography
- the target carrier on which the starting metal isotope is deposited, is dissolved together with the target and subsequently removed from the manufactured radioisotope by means of a purification process.
- a system for automatically producing radioisotopes characterized by comprising a target carrier; an electrodeposition unit for electrodepositing a target in said target carrier; an irradiation unit for irradiating said target in said target carrier; first transfer means for transferring the target carrier from the electrodeposition unit to the irradiation unit; an electrodissolution unit for electrodissolving the irradiated target without corroding said target carrier ( 8 ); second transfer means for transferring the target carrier from the irradiation unit to the electrodissolution unit; a purifying unit for purifying the radioisotope of the non-reacting target and impurities; third transfer means for transferring the electrodissolved irradiated target from the electrodissolution unit to the purifying unit; and a central control unit for controlling the operating units and transfer means to automate the entire process.
- the electrodeposition unit and the electrodissolution unit comprise the same electrolytic cell, and the first transfer means and second transfer means coincide.
- first transfer means and second transfer means comprise a conduit connected to a pneumatic system and housing said target carrier in sliding manner.
- FIG. 1 shows an overall view of a preferred embodiment of the system for automatically producing radioisotopes according to the present invention
- FIG. 2 shows a section of the target carrier used in the system according to the present invention
- FIG. 2 a shows a section of the target carrier according to another embodiment
- FIG. 3 shows a view in perspective of a supporting structure of the electrolysis unit of the FIG. 1 system
- FIG. 4 shows a section of the electrolysis unit of the FIG. 1 system
- FIG. 4 a shows a section of the electrolysis unit according to another embodiment
- FIG. 5 shows a view in perspective of the irradiation unit of the FIG. 1 system
- FIG. 6 shows a section of a detail of the FIG. 5 irradiation unit
- FIG. 7 shows a front view of the purifying unit of the FIG. 1 system.
- Number 1 in FIG. 1 indicates as a whole the system for automatically producing radioisotopes according to the present invention.
- System 1 comprises an electrolysis unit 2 for both electrodeposition and electrodissolution; an irradiation unit 3 fixed directly to a cyclotron C; a purifying unit 4 ; transfer means 5 for transferring the target between electrolysis unit 2 and irradiation unit 3 ; transfer means 6 for transferring the dissolved target from electrolysis unit 2 to purifying unit 4 ; and a central control unit 7 for fully controlling operation of system 1 .
- System 1 comprises a target carrier 8 ( FIG. 2 ) defined by a cylindrical wall 9 having a truncated-cone-shaped end portion 10 , and by a partition wall 11 inside and perpendicular to cylindrical wall 9 .
- Partition wall 11 and cylindrical wall 9 define two separate cylindrical cavities 12 and 13 . More specifically, cylindrical wall 9 thickens inwards at cavity 12 ; cylindrical wall 9 and partition wall 11 are made of aluminium or stainless steel; and cylindrical cavity 12 is lined with a coating 12 a of platinum or niobium or iridium.
- a hole 11 a is made in the partition wall 11 to allow a more effective cooling of the coating 12 a.
- electrolysis unit 2 is supported on a supporting structure 14 , which comprises a gripping head 15 ; four supporting members 16 on which to store four target carriers 8 ; and a terminal 17 for connecting a conduit 18 , as described below.
- Gripping head 15 is connected to a vacuum pump by a fitting 15 a , and is moved vertically by a pneumatic cylinder and horizontally by a screw-nut screw system connected to a toothed belt.
- Each supporting member 16 has a target carrier presence sensor.
- Electrolysis unit 2 comprises an electrolytic cell 19 ; and a heater 20 housed, in use, inside cylindrical cavity 13 of target carrier 8 .
- electrolytic cell 19 comprises a delivery tube 21 ; a return tube 22 defining the dissolved target transfer means 6 ; a platinum electrode 23 with a corresponding platinum wire 24 ; a gold or platinum disk electrode 25 ; and four springs 26 wound about respective assembly screws, and which act on a disk body 27 for disconnecting target carrier 8 .
- electrolytic cell 19 comprises a platinum electrode 23 a connected with a platinum tube 24 a , in which an electrolytic solution comprising the metal to be deposited is fed.
- the platinum tubee 24 a works as a delivery tube and the tubes 21 e 22 are used to remove the electrolytic solution or to clean the electrolytic cell 19 .
- the four springs 26 and the disk body 27 are absent, and other means (not shown) are used for disconnecting target-carrier 8 .
- Heater 20 comprises an electric resistor 28 , and a temperature probe 29 .
- transfer means 5 for transferring target carrier 8 comprise a conduit 18 connected to a known pneumatic system (not shown for the sake of simplicity) by which the target carrier is pushed or drawn along conduit 18 .
- irradiation unit 3 comprises a grip pin 31 housed in use inside cylindrical cavity 13 of target carrier 8 ; a rotary actuator 32 connected to grip pin 31 ; a linear actuator 33 also connected to grip pin 31 ; and a pneumatic cylinder 34 connected to a terminal 35 of conduit 18 .
- inside grip pin 31 are formed a central cooling water feed conduit 36 connected to a fitting 37 ; an intermediate annular cooling water return conduit 38 connected to a fitting 39 ; and an outer annular conduit 40 connected to a vacuum pump by a fitting 41 .
- purification unit 4 comprises an ionic purification column 42 , two pumps 43 , a reactor 44 , and a network of valves and vessels, and is electronically controlled to supply electrolytic cell 19 with the appropriate electrolytic solution containing the isotopes of the metals to be electrodeposited inside cavity 12 of target carrier 8 , to supply electrolytic cell 19 with an HNO 3 solution for electrodissolving the irradiated target, to separate the radioisotope from the starting isotope and other radioactive impurities by ion chromatography, and to supply solvents for cleaning electrolytic cell 19 , the transfer lines, and the components used to separate the radioisotope.
- a target carrier 8 is picked up by gripping head 15 and placed on heater 20 , so that heater 20 is housed inside cylindrical cavity 13 of target carrier 8 ; and electrolytic cell 19 is then lowered into the FIG. 4 position, i.e. in which disk electrode 25 contacts an edge portion of coating 12 a of cylindrical cavity 12 of target carrier 8 .
- an electrolytic solution from purifying unit 4 and in which the isotope of the metal to be deposited is dissolved, is fed in by delivery tube 21 or by the platinum pipe 24 a . As the solution flows in, the difference in potential is applied to the electrodes, and the isotope for irradiation is deposited.
- electrolytic solution is removed, and electrolytic cell 19 and cylindrical cavity 12 are cleaned using deionized water and ethyl alcohol in succession, which are then removed by a stream of helium.
- target carrier 8 is heated and maintained in a stream of gas to dry the deposited metal.
- electrolytic cell 19 is raised, and gripping head 15 removes target carrier 8 and places it either on a supporting member 16 , pending irradiation, or directly inside terminal 17 , from which it is blown inside conduit 18 by a stream of compressed air.
- Target carrier 8 is fed along conduit 18 to terminal 35 of irradiation unit 3 , where the presence of carrier 8 is detected by a sensor.
- target carrier 8 On reaching terminal 35 , target carrier 8 is retained by grip pin 31 by virtue of the vacuum produced in outer annular conduit 40 . Pneumatic cylinder 34 then lowers terminal 35 and conduit 18 , and rotary actuator 32 and linear actuator 33 move grip pin 31 and target carrier 8 into the irradiation position. More specifically, carrier 8 is successively rotated 90° and translated to position cylindrical cavity 12 facing an irradiation opening 45 shown in FIG. 5 . Once irradiated, target carrier 8 is replaced inside terminal 35 by linear actuator 33 , rotary actuator 32 , and pneumatic cylinder 34 ; at which point, the vacuum holding target carrier 8 on grip pin 31 is cut off, and the vacuum pump connected to conduit 18 is activated to return target carrier 8 to terminal 17 .
- the target carrier On reaching terminal 17 , the target carrier is picked up by gripping head 15 and placed back on heater 20 as described previously; at which point, electrolytic cell 19 is lowered so that disk electrode 25 contacts the edge portion of coating 12 a of cylindrical cavity 12 of target carrier 8 .
- electrolytic cell 19 is lowered so that disk electrode 25 contacts the edge portion of coating 12 a of cylindrical cavity 12 of target carrier 8 .
- a portion of the coating of cylindrical cavity 12 is preferably left exposed to employ its catalyst properties for the electrodissolution reaction.
- electrodissolution is performed, by inverting one polarity of the electrodes with respect to electrodeposition, and the resulting solution is sent by a stream of inert gas to purifying unit 4 .
- the electrolysis unit is cleaned and dried using deionized water and ethyl alcohol, after which, gripping head 15 can pick up another target carrier 8 and commence another work cycle.
- the acid solution from the electrodissolution operation and therefore containing the starting metal isotope and the radioisotope obtained by irradiation, is transferred to reactor 44 where the nitric acid is evaporated.
- the isotope/radioisotope mixture is re-dissolved in a hydrochloric acid solution, radioactivity is measured, and the solution is transferred in a stream of helium to ionic purification column 42 .
- the starting metal isotope is recovered and used for further deposition.
- a solution of 10 ml of ( 60 Ni, 61 Ni, 64 Ni) comprising nickel sulphate and boric acid is fed into a vessel in purifying unit 4 .
- target carrier 8 and electrolytic cell 19 are set up as shown in FIG. 4 , the nickel-containing acid solution is circulated, at a temperature of 25° to 50° C., inside cylindrical cavity 12 of target carrier 8 by a closed-circuit system supplied by one of pumps 43 .
- the voltage control is activated automatically and turns on the voltage and current supply pre-set to 3V and 20 mA.
- the electrodeposition operation lasts an average of 24 h, after which, the system is arrested and, once the electrolytic solution circuit is emptied, electrolytic cell 19 and cavity 12 are cleaned using deionized water and ethyl alcohol in succession. Once the cleaning solvents are eliminated, target carrier 8 is heated to 60° C. and maintained in a stream of gas for at least 15 minutes to dry the surface of the nickel deposit. The average yield of metal nickel on the bottom of cylindrical cavity 12 corresponds to 50 ⁇ 2% of the initially dissolved nickel.
- target carrier 8 is transferred automatically along conduit 18 to the irradiation unit, and, after irradiation, is transferred automatically back to electrolysis unit 2 .
- electrolytic cell 19 while ensuring disk electrode 25 remains contacting the edge portion of coating 12 a , is raised roughly 0.2 mm corresponding to an 88 cm 2 free-platinum surface formed on the lateral wall of cylindrical cavity 12 .
- the free-platinum surface acts as a catalyst in dissolving the nickel, which is done using a 5 ml solution of nitric acid 4 M contained in a vessel in purifying unit 4 .
- the acid solution is circulated for about 10-20 minutes, at a flow rate of 0.5-2 ml/min, inside cylindrical cavity 12 of target carrier 8 heated to a temperature of 25 to 50° C.; in which conditions, dissolution of the target is quantitative.
- the acid solution containing the dissolved nickel and the manufactured radioisotope ( 60 Cu, 61 Cu, 64 Cu) is transferred automatically to purifying unit 4 , where the manufactured radioisotope ( 60 Cu, 61 Cu, 64 Cu) is separated from the respective starting nickel isotope and any other radioactive and metal impurities.
- a 10 ml solution of cadmium-110 comprising cadmium fluoborate and ammonium fluoborate is fed into a vessel in purifying unit 4 and to electrodeposition unit 2 , where target carrier 8 and electrolytic cell 19 are set up as shown in FIG. 4 .
- the acid solution is circulated, at a temperature of 30° C. and a flow rate of 0.5-2 ml/min, inside cylindrical cavity 12 by a closed-circuit system fed by one of pumps 43 ; and, in these conditions, 0.02 A current and 3V voltage are applied for about 4-6 h to deposit at least 40 mg of cadmium-110.
- the system is cleaned with deionized water and ethyl alcohol, and, once the cleaning solvents are removed, target carrier 8 is heated to 60° C. and maintained in a stream of gas for at least 15 minutes to dry the surface of the cadmium-110 deposit.
- target carrier 8 is transferred automatically along conduit 18 to the irradiation unit, and, after irradiation, is transferred automatically back to electrolysis unit 2 .
- Electrodissolution is performed using a 4 ml solution of nitric acid 4 M contained in a vessel in purifying unit 4 .
- the acid solution is circulated for about 2 minutes at a flow rate of 0.5-2 ml/min inside cylindrical cavity 12 of target carrier 8 maintained at ambient temperature; in which conditions, dissolution is quantitative.
- dissolution is completed, the acid solution containing cadmium-110/indium-110 is transferred automatically to purifying unit 4 , where the indium-110 is separated by ionic purification from the cadmium-110 and any other radioactive and metal impurities.
- the system according to the present invention has the advantage of preparing radioisotopes automatically and so ensuring high output levels.
- the system according to the present invention avoids dissolution of the target carrier, with obvious advantages at the purification stage.
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Electrochemistry (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Optics & Photonics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Electrolytic Production Of Metals (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Particle Accelerators (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05425262.2 | 2005-04-27 | ||
EP05425262A EP1717819B1 (de) | 2005-04-27 | 2005-04-27 | System zur automatischen Gewinnung von Radioisotopen |
PCT/EP2006/061853 WO2006114433A2 (en) | 2005-04-27 | 2006-04-26 | System for automatically producing radioisotopes |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100025251A1 true US20100025251A1 (en) | 2010-02-04 |
Family
ID=35677483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/919,509 Abandoned US20100025251A1 (en) | 2005-04-27 | 2006-04-24 | System for automatically producing radioisotopes |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100025251A1 (de) |
EP (1) | EP1717819B1 (de) |
AT (1) | ATE517418T1 (de) |
CA (1) | CA2606643C (de) |
DK (1) | DK1717819T3 (de) |
ES (1) | ES2369482T3 (de) |
WO (1) | WO2006114433A2 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9991013B2 (en) | 2015-06-30 | 2018-06-05 | General Electric Company | Production assemblies and removable target assemblies for isotope production |
CN112789688A (zh) * | 2018-08-27 | 2021-05-11 | Bwxt同位素技术集团有限公司 | 产生放射性同位素的气动靶辐照系统 |
CN113574613A (zh) * | 2019-03-28 | 2021-10-29 | 住友重机械工业株式会社 | 靶照射系统及来自固体靶的放射性同位素的回收方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7781744B2 (en) * | 2008-08-21 | 2010-08-24 | Comecer S.P.A. | Procedure for the preparation of radioisotopes |
DE102009005893B3 (de) * | 2009-01-23 | 2010-12-02 | Forschungszentrum Jülich GmbH | Verfahren zur Erzeugung von 11C sowie Targetkörper |
WO2012039036A1 (ja) * | 2010-09-22 | 2012-03-29 | 独立行政法人放射線医学総合研究所 | 加速器による放射性核種の製造方法及び装置 |
EP3608921B1 (de) | 2018-08-06 | 2020-12-16 | Ion Beam Applications S.A. | Kapsel für ein targetmaterial und einrichtung zur bestrahlung dieses targetmaterials |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011825A (en) * | 1995-08-09 | 2000-01-04 | Washington University | Production of 64 Cu and other radionuclides using a charged-particle accelerator |
US6221437B1 (en) * | 1999-04-12 | 2001-04-24 | Reynolds Tech Fabricators, Inc. | Heated workpiece holder for wet plating bath |
US20050006245A1 (en) * | 2003-07-08 | 2005-01-13 | Applied Materials, Inc. | Multiple-step electrodeposition process for direct copper plating on barrier metals |
US20050121337A1 (en) * | 2003-09-08 | 2005-06-09 | Ion Beam Applications S.A. | Method and apparatus for the electrodissolution of elements |
US20070297554A1 (en) * | 2004-09-28 | 2007-12-27 | Efraim Lavie | Method And System For Production Of Radioisotopes, And Radioisotopes Produced Thereby |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA935943A (en) * | 1970-12-23 | 1973-10-23 | Union Carbide Corporation | Primary target for the production of fission products in a nuclear reactor and process for preparation |
US5037602A (en) * | 1989-03-14 | 1991-08-06 | Science Applications International Corporation | Radioisotope production facility for use with positron emission tomography |
CA2055297C (en) * | 1990-11-13 | 1996-10-08 | Iwao Kanno | Apparatus and method for producing and automatically injecting h--o |
US6153154A (en) * | 1998-05-27 | 2000-11-28 | Battelle Memorial Institute | Method for sequential injection of liquid samples for radioisotope separations |
US6157036A (en) * | 1998-12-02 | 2000-12-05 | Cedars-Sinai Medical Center | System and method for automatically eluting and concentrating a radioisotope |
-
2005
- 2005-04-27 EP EP05425262A patent/EP1717819B1/de active Active
- 2005-04-27 AT AT05425262T patent/ATE517418T1/de not_active IP Right Cessation
- 2005-04-27 ES ES05425262T patent/ES2369482T3/es active Active
- 2005-04-27 DK DK05425262.2T patent/DK1717819T3/da active
-
2006
- 2006-04-24 US US11/919,509 patent/US20100025251A1/en not_active Abandoned
- 2006-04-26 WO PCT/EP2006/061853 patent/WO2006114433A2/en active Application Filing
- 2006-04-26 CA CA2606643A patent/CA2606643C/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011825A (en) * | 1995-08-09 | 2000-01-04 | Washington University | Production of 64 Cu and other radionuclides using a charged-particle accelerator |
US6221437B1 (en) * | 1999-04-12 | 2001-04-24 | Reynolds Tech Fabricators, Inc. | Heated workpiece holder for wet plating bath |
US20050006245A1 (en) * | 2003-07-08 | 2005-01-13 | Applied Materials, Inc. | Multiple-step electrodeposition process for direct copper plating on barrier metals |
US20050121337A1 (en) * | 2003-09-08 | 2005-06-09 | Ion Beam Applications S.A. | Method and apparatus for the electrodissolution of elements |
US20070297554A1 (en) * | 2004-09-28 | 2007-12-27 | Efraim Lavie | Method And System For Production Of Radioisotopes, And Radioisotopes Produced Thereby |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9991013B2 (en) | 2015-06-30 | 2018-06-05 | General Electric Company | Production assemblies and removable target assemblies for isotope production |
CN112789688A (zh) * | 2018-08-27 | 2021-05-11 | Bwxt同位素技术集团有限公司 | 产生放射性同位素的气动靶辐照系统 |
CN113574613A (zh) * | 2019-03-28 | 2021-10-29 | 住友重机械工业株式会社 | 靶照射系统及来自固体靶的放射性同位素的回收方法 |
Also Published As
Publication number | Publication date |
---|---|
DK1717819T3 (da) | 2011-11-07 |
ES2369482T3 (es) | 2011-12-01 |
WO2006114433A3 (en) | 2007-02-22 |
EP1717819B1 (de) | 2011-07-20 |
EP1717819A1 (de) | 2006-11-02 |
WO2006114433A2 (en) | 2006-11-02 |
CA2606643C (en) | 2013-09-03 |
ATE517418T1 (de) | 2011-08-15 |
CA2606643A1 (en) | 2006-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8233580B2 (en) | Method and system for producing radioisotopes | |
CA2606643C (en) | System for automatically producing radioisotopes | |
JP7210648B2 (ja) | テクネチウム-99mのサイクロトロン生産のためのプロセス、システム、及び装置 | |
US6254552B1 (en) | Intra-coronary radiation devices containing Ce-144 or Ru-106 | |
AU739507B2 (en) | Stents with a radioactive surface coating, processes for their production and their use for restenosis prophylaxis | |
US6011825A (en) | Production of 64 Cu and other radionuclides using a charged-particle accelerator | |
JP6845371B1 (ja) | Ra−226からAc−225を製造する方法 | |
US6143431A (en) | Production of Palladium-103 | |
Sadeghi et al. | Cyclotron production of 68Ga via proton-induced reaction on 68Zn target | |
Zeisler et al. | Production of 64 Cu on the Sherbrooke TR-PET cyclotron | |
JP7168781B2 (ja) | Ac-225の製造方法 | |
JP7190200B2 (ja) | 加速器を用いた放射性核種の製造装置、製造方法、および放射性核種製造用容器 | |
US7781744B2 (en) | Procedure for the preparation of radioisotopes | |
EP1883079B1 (de) | Verfahren zur Herstellung von Radioisotopen | |
JP7288261B2 (ja) | 分離装置、分離方法、ri分離精製システムおよびri分離精製方法 | |
Enferadi et al. | Cyclotron production of 101Pd/101mRh radionuclide generator for radioimmunotherapy | |
Sadeghi et al. | Radiochemical studies relevant to the no-carrier-added production of 61, 64Cu at a cyclotron | |
Boldyrev et al. | Electrochemical method for producing radionuclide Lu-177 with high specific activity | |
Sadeghia et al. | Cyclotron production of 103Pd via proton-induced reactions on 103Rh target | |
JP2006110533A (ja) | ハロゲン由来の陽電子放出核種の分離回収方法、18F標識化合物の合成方法およびNa18Fの合成方法。 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: COMECER S.P.A.,ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BEDESCHI, PAOLO;REEL/FRAME:023372/0603 Effective date: 20091001 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: RECOMEC S.P.A., ITALY Free format text: CHANGE OF NAME;ASSIGNOR:COMECER S.P.A.;REEL/FRAME:030632/0249 Effective date: 20110429 |
|
AS | Assignment |
Owner name: COMECER S.P.A., ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:RECOMEC S.P.A.;REEL/FRAME:030643/0668 Effective date: 20130616 |