US20090155189A1 - Preparations, Methods and Kits Useful for the Treatment of Cough - Google Patents
Preparations, Methods and Kits Useful for the Treatment of Cough Download PDFInfo
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- US20090155189A1 US20090155189A1 US12/274,677 US27467708A US2009155189A1 US 20090155189 A1 US20090155189 A1 US 20090155189A1 US 27467708 A US27467708 A US 27467708A US 2009155189 A1 US2009155189 A1 US 2009155189A1
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- respiratory preparation
- preparation
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- agent
- extract
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- MAGQQZHFHJDIRE-BNFZFUHLSA-N CCCCC/C=C/C=C/C(=O)NCC(C)C Chemical compound CCCCC/C=C/C=C/C(=O)NCC(C)C MAGQQZHFHJDIRE-BNFZFUHLSA-N 0.000 description 2
- 0 [1*]CCCC/C=C/C=C/C(=O)N1[2*][3*]1 Chemical compound [1*]CCCC/C=C/C=C/C(=O)N1[2*][3*]1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Definitions
- the invention relates to a respiratory preparation providing cough relief in a human comprising: a thickening agent; a benefit agent; and wherein said respiratory preparation provides on demand relief.
- Post nasal drip is caused by the over secretion of mucous in the nasal cavity.
- the constant trickle of mucus in the throat results in triggering the cough reflex.
- inflammation may occur in the mucosa such that cytokines and inflammatory mediators are released into nasal secretions. These then bathe the throat and cause a sequence of pain/soreness that is much more easily aggravated by innocuous stimuli such as changes in air temperature (cold air) which stimulate the cough reflex.
- the cough reflex can also be stimulated by a dry mouth and/or throat.
- compositions such as cough drops, sore throat sprays, and cough syrups.
- the response of cough drops is not instant and drops are usually solid doses that must be melted in the mouth and provide no coating of the throat.
- Sore throat sprays can contain actives that numb the mouth and throat. Sprays normally contain instruction to not swallow so there is no throat coating and no cough relief.
- cough suppression can be enhanced by focused delivery of the active to the site of irritation, the target mucosa.
- targeted delivery such as that which is realized when a spray is used, is that the actives are not lost to irreversible binding to the mucin (via mucoadheasion) before they can reach the target sites.
- One embodiment is directed to a respiratory preparation providing cough relief in a human comprising: a thickening agent; a benefit agent; and wherein said respiratory preparation provides on demand relief.
- An additional embodiment further relates to a method of providing cough relief in a human comprising: the steps of administering to a human a respiratory preparation comprising: a thickening agent; a benefit agent; and wherein said respiratory preparation provides on demand cough relief.
- An additional embodiment is further directed to a kit comprising: a delivery device and a respiratory preparation contained in said delivery device; wherein said respiratory preparation comprising: a thickening agent; a benefit agent; and wherein said respiratory preparation provides on demand cough relief.
- One embodiment is directed to a respiratory preparation providing cough relief in a human comprising: a thickening agent; a benefit agent; and wherein said respiratory preparation provides on demand relief.
- compositions and/or preparations can be delivered by a delivery device selected from droppers, pump, sprayers, liquid dropper, cup, bottle, liquid filled gel, liquid filled gummy, center filled gum, chews, films, center filled lozenge, gum filled lozenge, pressurized sprayers, atomizers, air inhalation devices, liquid filled compressed tablet, liquid filled gelatin capsule, liquid filled capsule, and other packaging and equipment, and combinations thereof.
- a delivery device selected from droppers, pump, sprayers, liquid dropper, cup, bottle, liquid filled gel, liquid filled gummy, center filled gum, chews, films, center filled lozenge, gum filled lozenge, pressurized sprayers, atomizers, air inhalation devices, liquid filled compressed tablet, liquid filled gelatin capsule, liquid filled capsule, and other packaging and equipment, and combinations thereof.
- the sprayer, atomizer, and air inhalation devices can be associated with a battery or electric power source.
- compositions, preparations and methods of the present invention can comprise, consist of, or consist essentially of, the essential elements and limitations of the invention described herein, as well as any additional or optional ingredients, components, or limitations described herein or otherwise useful in compositions intended for use or consumption by mammals preferably consumption or use by humans.
- the present invention is a respiratory preparation.
- the respiratory preparation comprises a thickening agent; and a benefit agent.
- the preparation provides instant relief.
- the preparation can additionally, reduce inflammation and relieve minor pain associated with a cough and/or sore throat.
- the preparation can be in a delivery device that is convenient and easy to carry and can be used as often as needed.
- the preparation is delivered to a site of treatment with the delivery device.
- the site of treatment is the mouth and throat.
- the delivery device can be selected from the group consisting of pump, spray, liquid dropper, cup, bottle, liquid filled gel, liquid filled gummy, center filled gum, chews, films, center filled lozenge, gum filled lozenge, liquid filled compressed tablet, liquid filled gelatin capsule, liquid filled capsule, and combinations thereof.
- the preparation is an oral composition.
- the oral composition can be selected from the group consisting of liquid compositions, beverage, supplemental water, gel compositions, foam compositions, pills, tablets, soft gels or capsules, and combinations thereof.
- the preferred pH range of the preparation is from about 1 to about 7, from about 2 to about 6.5, from about 2 to about 5 and from about 2.6 to about 4.6.
- the preparation comprises a thickening agent.
- the preparation comprises from about 0.01% to about 60%, alternatively from about 0.1% to about 40%, alternatively from about 1% to about 30%, alternatively from about 2% to about 20%, alternatively from about 3% to about 15%, by weight of the preparation.
- the thickening agent can provide a moisturizing and/or hydration benefit that relieves the cough on contact and/or provides aid in healing the mouth and/or throat.
- Nonlimiting examples of thickening agents include carboxymethylcellulose (CMC), carboxymethylcellulose sodium; and mixtures thereof.
- the thickening agent is carboxymethylcellulose sodium.
- the preparation can comprise a benefit agent.
- the preparation comprises from about 0.01% to about 30%, alternatively from about 0.03% to about 25%, alternatively from about 0.05% to about 20%, alternatively from about 0.4% to about 20%, alternatively from about 1% to about 15%, alternatively from about 1.5% to about 10%, by weight of the preparation.
- the benefit agent can provide cooling and warming benefit to the mouth and/or throat, signal to the user that the preparation has reached the area of the mouth and/or throat where the cough is generated and can aid in providing immediate relief of the cough.
- Nonlimiting examples of benefit agents include cooling agents, warming agents, flavoring agents, salivating agents, and combinations thereof.
- cooling agents include WS-23 (2-Isopropyl-N,2,3-trimethylbutyramide), WS-3 (N-Ethyl-p-menthane-3-carboxamide), WS-30 (1-glyceryl-p-mentane-3-carboxylate), WS-4 (ethyleneglycol-p-methane-3-carboxylate), WS-14 (N-t-butyl-p-menthane-3-carboxamide), WS-12 (N-(4-, ethoxyphenyl)-p-menthane-3-carboxamide), WS-5 (Ethyl-3-(p-menthane-3-carboxamido)acetate, Menthone glycerol ketal (sold as Frescolat® MGA by Haarmann & Reimer), ( ⁇ )-Menthyl lactate (sold as Frescolat® ML
- Nonlimiting examples of warming agents include TK 1000, TK 1 MM, Heatenol—Sensient Flavors, Optaheat—Symrise Flavors, Cinnamon, Glycerine, Propylene glycol, Polyethylene glycol, Capsicum, Capsaicin, Curry, FSI Flavors.
- Nonlimiting examples of flavoring agents include natural, artificial, artificial extracts, natural extracts and combination thereof.
- Nonlimiting examples of flavoring agents include: Vanilla, honey lemon, lemon honey, cherry vanilla, peach, honey ginger, cherry, cherry cream, mint, vanilla mint, dark berry, black berry, raspberry, peppermint, spearmint, honey peach, acai berry, cranberry, honey cranberry, tropical fruit, dragon fruit, wolf berry, red stem mint, pomegranate, black current, strawberry, lemon, lime, peach ginger, orange, orange cream, cream sickle, apricot, anethole, ginger, jack fruit, star fruit, blueberry, fruit punch, lemon grass, chamomile lemon grass, lavender, banana, strawberry banana, grape, blue raspberry, lemon lime, coffee, espresso, cappuccino, honey, wintergreen mint, bubble gum, tart honey lemon, sour lemon, green apple, boysenberry, rhubarb, strawberry rhubarb, persimmon, green tea, black tea, red tea
- salivating agents include formula (I):
- R 1 represents C1-C2 n-alkyl
- R 2 is 2-methyl-1-propyl and R 3 is hydrogen, or R 2 and R 3 taken together is a moiety having the formula —(CH 2 ) n — wherein n is 4 or 5, or mixtures thereof.
- the salivating agent comprises a material wherein R 2 is 2-methyl-1-propyl and R 3 is hydrogen, more preferably wherein R 1 is C1 n-alkyl, R 2 is 2-methyl-1-propyl and R 3 is hydrogen. More preferably, the salivating agent comprises trans-pellitorin, a chemical having a structure according to formula (II):
- the respiratory preparation can further comprise at least one additional component.
- the preparation comprises from about 0.1% to about 20% of an additional component, by weight of the preparation, alternatively from about 0.5% to about 15%, alternatively from about 1% to about 10%, alternatively from about 1.5% to about 5%, alternatively from about 2% to about 4% of an additional ingredient, by weight of the preparation.
- Nonlimiting Examples of an additional component includes, tea extract, Vitamin A, Vitamin C, Vitamin B, Vitamin D, carotenoid, rosemary, rosemary extract, caffeic acid, coffee extract, tumeric extract, curcumin, blueberry extract, grapeseed extract, rosemaric acid, antioxidant, amino acid, enzyme, prebiotic, probiotic, andrographis extract, 1-tryptophan, Allium sativum , herbal remedies, vitamins, supplements, antioxidants, natural ingredients, minerals, energy boosting ingredients, sleep aids, immune system boosting agents, colorant, preservative, fragrance, flavorant, fruit extract, a salivating agent, a salivating stimulator, and combinations thereof.
- Vitamin C for use in the preparation is as ascorbic acid or the equivalent of a salt of ascorbic acid or the equivalent of a derivative of ascorbic acid.
- the vitamin C may either be in an immediate release form or a sustained release form.
- Vitamin A and carotene can be obtained from either animal or vegetable sources.
- the vitamin A can be in the form of vitamin A, retinol, retinyl palmitate, retinyl acetate, retinyl proprionate, beta-carotene, alpha carotene, beta-cryptoxanthin, and mixtures thereof.
- Vitamin D examples include Vitamin D3 (cholecalciferol), Vitamin D2 (ergocalciferol) and combinations thereof. Additional, nonlimiting examples also include metabolites of Vitamin D, including calcidiol, calcitriol, and combinations thereof.
- the Vitamin D including cholecalciferol, ergocalciferol, calcidiol and calcitriol, may be derived from synthetic or natural sources. Vitamin D, including cholecalciferol and calcitriol, may be sourced from an extract of solanum glaucophyllum (malacoxylon), trisetum flavescens (goldhafer) or cestrum diumum. Both the pure, Vitamin D and/or glycosides of the Vitamin D, may be used.
- Tea extract is a polyphenol.
- Nonlimiting examples of extracts includes Camellia sinensis .
- Nonlimiting sources of tea extract for use in the present invention are black tea, white tea, oolong tea, and/or green tea.
- the preparation can comprise from about 10 6 to 10 12 cfU of a probiotic, and alternatively from about 10 6 to 10 10 cfu of a probiotic.
- the probiotic component can be a lactic acid bacteria.
- the probiotic is selected from the group consisting of bacteria of the genera Bacillus, Bacteroides, Bifidobacterium, Enterococcus (e.g., Enterococcus faecium ), Lactobacillus , and Leuconostoc , and combinations thereof.
- the probiotic is selected from bacteria of the genera Bifidobacterium, Lactobacillus , and combinations thereof.
- Non-limiting examples of lactic acid bacteria suitable for use herein include strains of Streptococcus lactis, Streptococcus cremoris, Streptococcus diacetylactis, Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus acidophilus (e.g., Lactobacillus acidophilus strain), Lactobacillus helveticus, Lactobacillus bifidus, Lactobacillus casei, Lactobacillus lactis, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus delbruekii, Lactobacillus thermophilus, Lactobacillusfermentii, Lactobacillus salivarius, Lactobacillus reuteri, Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium bifidum, Bifidobacterium animalis, Bifido
- Prebiotics which are useful include beet pulp, carob bean, psyllium, citrus pectin, rice bran, locust bean, fructooligosaccharide, inulin, oligofructose, galactooligosaccharide, citrus pulp, mannanoligosaccharides, arabinogalactan, lactosucrose, glucomannan, lactulose, polydextrose, apple pomace, tomato pomace, carrot pomace, cassia gum, xanthan gum, gum karaya, gum talha, gum arabic, cellulose, hemicellulose, cellulose ethers, lignin and combinations thereof.
- the andrographis is a plant of the genus Andrographis , having a limited number of species within this genus largely present in Asia. Only a few of the species are medicinal.
- the plant is of the species Andrographis paniculata , which may be referenced as Kalmegh in Ayurvedic medicine.
- Coffee extract is a polyphenol.
- the main constituent of coffee extract is coffeic acid.
- coffee extract is present nonlimiting sources of coffee extract include coffee, coffee bean, coffee berry, and/or coffee fruits.
- coffeic acid is present nonlimiting sources of coffeic acid include coffee bean, coffee fruits, coffee, tea, berries, rosemary extract, and/or grapes extract.
- Turmeric extract is a polyphenol.
- Turmeric extract is a spice which comprises a main active compound that is curcumin.
- Curcumin is a bioactive polyphenol plant pigment.
- Nonlimiting source of turmeric extract for use in the present invention is turmeric.
- Blueberry extract is a polyphenol.
- the blueberry extract is rich in anthocyanins which display antioxidant activity.
- Grapeseed extract is a polyphenol.
- the grape seed extract is rich in procyanidins which display antioxidant activity.
- Nonlimiting source of grapeseed extract for use in the present invention is grape seed.
- Amino acids are the “building Blocks” of the body. Besides building cells and repairing tissue, they form antibodies to combat invading bacteria & viruses; they are part of the enzyme & hormonal system; they carry oxygen throughout the body and participate in muscle activity.
- the amino acid is selected from the group consisting of Lysine, Taurine, Histidine, Carnosine, Alanine, Cysteine, and mixtures thereof.
- Example of antivirals include: amantidine, rimantidine, pleconaril, zanamivir, and oseltamivir.
- Examples of antitussives include codeine, dextromethorphan, chlophedianol and levodropropizine.
- Examples of expectorants include guaifenesin.
- Examples of mucolytics include ambroxol and N-acetylcysteine.
- antihistamines include diphenhydramine, doxylamine, triprolidine, clemastine, pheniramine, chlorpheniramine, brompheniramine, Dexbrompheniramine, loratadine, cetirizine and fexofenadine, Amlexanox, Alkylamine Derivatives, Cromolyn, Acrivastine, Ibudilast, Bamipine, Ketotifen, Nedocromil, Omalizumab, Dimethindene, Oxatomide, Pemirolast, Pyrrobutamine, Pentigetide, Thenaldine, Picumast, Tolpropamine, Ramatroban, Triprolidine, Repirinast, Suplatast Tosylate Aminoalkylethers, Tazanolast, Bromodiphenhydramine, Tranilast, Carbinoxamine, Traxanox, Chlorphenoxamine, Diphenhydramine, Diphenylpyaline
- the preparation may comprise an amount of respiratory ingredient in the range of from about 0% to about 15%, alternatively 0.0001% to about 10%, alternatively from about 0.001% to about 7%, and alternatively from about 0.01% to about 5%, all by weight of the preparation.
- the respiratory preparation may comprise a sweetener to provide sweetness and aid in the taste masking of a respiratory ingredient(s) as well as to provide some body and thickness.
- a sweetener is present in the preparation, the preparation may comprise from about 0.0001% to about 40% sweetener, from about 0.0001% to about 20% sweetener, alternatively from about from about 0.0001% to about 10% sweetener, alternatively from about from about 0.0001% to about 2% sweetener and alternatively from about 0.05% to about 1.0% sweetener, all by weight of the preparation.
- the sweeteners can be artificial sweeteners and/or natural sweeteners.
- Non-limiting examples of artificial sweeteners are selected from the group consisting of sodium saccharine, acesulfame potassium, sucralose, aspartame, monoammonium glycyrrhizinate, neohesperidin dihydrochalcone, thaumatin, neotame, cyclamates, stevia, and mixtures thereof.
- such artificial sweeteners are solids when used in sweetening the respiratory preparations.
- the preparations can comprise a wide range of optional ingredients.
- optional ingredients include antimicrobial metal salts, optional mildness enhancers, optional stabilizers, abrasives, biological additives, chemical additives, chelants, denaturants, drug astringents, emulsifiers, external analgesics, film formers, fragrance compounds, humectants, opacifying agents, plasticizers, propellants, reducing agents, solvents, foam boosters, stabilizers, hydrotropes, solublizing agents, suspending agents (non-surfactant), a solvent, viscosity increasing agents (aqueous and non-aqueous), sequestrants, buffers, keratolytics, and the like, and combinations thereof.
- Nonlimiting examples of antimicrobial metal salts include zinc, iron, copper, silver, tin, bismuth, and combinations thereof.
- the preparations may optionally comprise one or more given optional ingredients at concentrations ranging from about 0.001% to about 99%, alternatively from about 0.01% to about 80%, alternatively from about 0.01% to about 50%, alternatively from about 0.01% to about 10%, all by weight of the preparation.
- the term “orally administering” and/or “administering” with respect to the human/mammal means that the human/mammal ingests or is directed to ingest, or does ingest, or deliver, or chew, or drink, or spray, or place in mouth, one or more of the present respiratory preparations.
- the human/mammal may be directed to deliver the respiratory preparation to the site that the human/mammal intends to treat for example the mouth and/or throat.
- the human/mammal may be directed to ingest or deliver or chew, or drink, or spray, or place in mouth the preparation, such direction and or deliver may be that which instructs and/or informs the human that use of the preparation may and/or will provide relief from the respiratory symptom (e.g., symptomatic relief, whether temporary or permanent) for example, relief from coughing and/or sore throat.
- the respiratory symptom e.g., symptomatic relief, whether temporary or permanent
- such direction may be oral direction (e.g., through oral instruction from, for example, a physician, pharmacist, or other health professional), radio or television media (e.g., advertisement), or written direction (e.g., through written direction from, for example, a physician, pharmacist, or other health professional (e.g., scripts), sales professional organization (e.g., through, for example, marketing brochures, pamphlets, or other instructive paraphernalia), written media (e.g., internet, electronic mail, or other computer-related media)), and/or packaging associated with the composition (e.g., a label present on a delivery device holding the preparation).
- written means through words, pictures, symbols, and/or other visible or tactile descriptors.
- the present invention can also be directed to methods of “prevention” including preventing a cough or its associated symptoms from occurring in a mammal, for example when the mammal is predisposed to acquiring the symptoms of coughing, inhibiting the onset of coughing or its associated symptoms; and/or alleviating, reversing, or curing the coughing episode or its associated symptoms.
- Administration may be on an as-needed or as-desired basis, for example, once-monthly, once-weekly, or daily, including multiple times daily, for example, at least once daily, from one to about six times daily, from about two to about four times daily, or about three times daily.
- the amount of respiratory preparation administered may be dependent on a variety of factors, including the general quality of health of the mammal, age, gender, weight, or severity of symptoms.
- the respiratory preparations may be prepared by any known or otherwise effective techniques suitable for providing a composition that provides a therapeutic benefit.
- the respiratory preparation is made by combining thickening agent with a solvent.
- the combined ingredients are then added to a mixing vessel containing flavors, demulcents, solvents, sweeteners, preservatives and mixed until homogenous.
- the preparation is packaged into spray bottles
- the respiratory preparation is made by combining the thickening agent with a solvent.
- a separate vessel the following are then added to a mixing vessel containing flavoring agent, demulcents, solvents, sweeteners, preservatives, heating and blending until uniform.
- the combined ingredients from the mixing vessel are added while above 60 C to a mold, and the thickening agent and solvent are injected into the center of the mold, and do not harden.
- the shell layer will harden, leaving the thickening agent and solvent in the center.
- the preparation is ejected from the mold and wrapped in a suitable delivery device.
- the preparation in the delivery device is a preparation for coughing the coordinating preparation and or composition may be for runny nose, nasal or chest congestion, sneezing, pressure, headache, aches, fever, or sore throat.
- the preparation in the delivery device is a preparation for coughing the coordinating preparation and/or composition may be a vitamin.
- the kit may further comprise a coupon, rebate, or advertisement.
- the kit may further comprise a set of instructions. These instructions may also include illustrations.
- Example 1 can be made by first adding water, citric acid, and sodium CMC to a clean vessel. The contents are stirred until the CMC disperses. In a separate clean vessel the propylene glycol, glycerin, sucrose, flavors, sodium citrate and sodium benzoate are added and stirred until dissolved. The two mixtures are then combined and mixed until homogenous and then placed in a delivery device comprising the material Polyethylene Terephthalate (PET).
- PET Polyethylene Terephthalate
- Example 2 can be made by first adding water, and sodium CMC to a clean vessel. The contents are stirred until the CMC disperses. In a separate clean vessel the propylene glycol, sucralose, sorbitol, flavors, and sodium benzoate are added and stirred until dissolved. The two mixtures are then combined and mixed until homogenous and then placed in a delivery device comprising the material PET.
- PET Polyethylene Terephthalate
- Examples 3-5 can be made by first adding water, citric acid, and sodium CMC to a clean vessel. The contents are stirred until the CMC disperses. In a separate clean vessel the high fructose corn syrup, propylene glycol, pharmaceutical actives (Chlorpheniramine Maleate, Guaifenesin, Dextromethoraphan HBr), menthol, sucrose, flavors, sodium citrate and sodium benzoate are added and stirred until dissolved. The two mixtures are then combined and mixed until homogenous and then placed in a delivery device comprising the material PET.
- pharmaceutical actives Chlorpheniramine Maleate, Guaifenesin, Dextromethoraphan HBr
- menthol menthol
- sucrose flavors
- sodium citrate sodium benzoate
- Examples 6-7 can be made by first, add propylene glycol, and alcohol to a clean vessel.
- water is added to dissolve phenylephrine, color, buffering agents, and sweeteners.
- the aqueous solution is added to the propylene glycol solution.
- the resulting composition is mixed with sucrose sweetener solution and additional water and the composition is mixed until homogeneous and then placed in a device comprising the material PET.
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/274,677 US20090155189A1 (en) | 2007-11-21 | 2008-11-20 | Preparations, Methods and Kits Useful for the Treatment of Cough |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US388607P | 2007-11-21 | 2007-11-21 | |
US2854708P | 2008-02-14 | 2008-02-14 | |
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Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011100267A1 (en) * | 2010-02-10 | 2011-08-18 | The Procter & Gamble Company | Liquid composition comprising a non-menthol cooling agent and a thickener for treating a respiratory symptom |
CN102753145A (zh) * | 2010-02-10 | 2012-10-24 | 宝洁公司 | 用于治疗呼吸道症状的包含非薄荷醇凉爽剂和增稠剂的液体组合物 |
AU2011215947B2 (en) * | 2010-02-10 | 2014-07-10 | The Procter & Gamble Company | Liquid composition comprising a non-menthol cooling agent and a thickener for treating a respiratory symptom |
AU2011215947C1 (en) * | 2010-02-10 | 2014-07-24 | The Procter & Gamble Company | Liquid composition comprising a non-menthol cooling agent and a thickener for treating a respiratory symptom |
US20110195042A1 (en) * | 2010-02-10 | 2011-08-11 | Thomas Edward Huetter | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom |
WO2013154347A1 (en) * | 2012-04-10 | 2013-10-17 | Hanmi Pharm. Co., Ltd. | Liquid formulation for oral administration comprising ambroxol, levodropropizine and buffering agent, and method for preparing the same |
AU2013312194B2 (en) * | 2012-09-10 | 2018-01-04 | Johnson & Johnson Consumer Inc. | Mouth rinses and tooth sensitivity treatment compositions |
AU2013312194C1 (en) * | 2012-09-10 | 2018-04-26 | Johnson & Johnson Consumer Inc. | Mouth rinses and tooth sensitivity treatment compositions |
US8771651B2 (en) * | 2012-09-10 | 2014-07-08 | Johnson & Johnson Consumer Companies, Inc. | Mouth rinses and tooth sensitivity treatment compositions |
US20150273009A1 (en) * | 2012-10-17 | 2015-10-01 | Montero Gida Sanayi Ve Ticaret A.S. | New formulations comprising plant extracts |
US20150290253A1 (en) * | 2012-10-17 | 2015-10-15 | Montero Gida Sanayi Ve Ticaret A.S. | Herbal formulations |
US10111912B2 (en) * | 2012-10-17 | 2018-10-30 | Montero Gida Sanayi Ve Ticaret A.S. | Herbal formulations |
US10111925B2 (en) * | 2012-10-17 | 2018-10-30 | Montero Gida Sanayi Ve Ticaret A.S. | Formulations comprising plant extracts |
US9457085B2 (en) | 2013-02-13 | 2016-10-04 | The Procter & Gamble Company | Anise flavored medication |
US9839620B2 (en) | 2013-02-13 | 2017-12-12 | The Procter & Gamble Company | Anise flavored medication |
US10071067B2 (en) | 2013-02-13 | 2018-09-11 | The Procter & Gamble Company | Anise flavored medication |
US10588872B2 (en) | 2013-02-13 | 2020-03-17 | The Procter & Gamble Company | Anise flavored medication |
CN103875802A (zh) * | 2014-04-15 | 2014-06-25 | 厦门绿链集成服务有限公司 | 一种新鲜水果的保鲜方法 |
US11273123B2 (en) | 2018-07-18 | 2022-03-15 | USpharma Ltd | Chewable pharmaceutical dosage forms |
Also Published As
Publication number | Publication date |
---|---|
ES2655477T3 (es) | 2018-02-20 |
EP2219677A1 (en) | 2010-08-25 |
CN101868253A (zh) | 2010-10-20 |
EP2217279A2 (en) | 2010-08-18 |
AU2008326386A1 (en) | 2009-05-28 |
CA2706472A1 (en) | 2009-05-28 |
EP2217279B1 (en) | 2017-11-01 |
US20090130199A1 (en) | 2009-05-21 |
MX2010005643A (es) | 2010-07-30 |
CA2706440C (en) | 2014-03-25 |
RU2476240C2 (ru) | 2013-02-27 |
CA2706440A1 (en) | 2009-05-28 |
US9149429B2 (en) | 2015-10-06 |
WO2009067605A2 (en) | 2009-05-28 |
WO2009066262A1 (en) | 2009-05-28 |
RU2010116996A (ru) | 2011-12-27 |
MX2010005642A (es) | 2010-07-30 |
BRPI0819819A2 (pt) | 2015-05-26 |
JP2011504184A (ja) | 2011-02-03 |
AU2008326386B2 (en) | 2014-07-31 |
MX337194B (es) | 2016-02-15 |
BRPI0819338A2 (pt) | 2015-05-19 |
US20160000925A1 (en) | 2016-01-07 |
WO2009067605A3 (en) | 2010-02-11 |
CN101868252A (zh) | 2010-10-20 |
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