US20080202949A1 - Reservoir With a Cutter for Substances to be Mixed With Liquids at Moment of Use in Particular for Single-Dose Containers - Google Patents
Reservoir With a Cutter for Substances to be Mixed With Liquids at Moment of Use in Particular for Single-Dose Containers Download PDFInfo
- Publication number
- US20080202949A1 US20080202949A1 US11/915,507 US91550705A US2008202949A1 US 20080202949 A1 US20080202949 A1 US 20080202949A1 US 91550705 A US91550705 A US 91550705A US 2008202949 A1 US2008202949 A1 US 2008202949A1
- Authority
- US
- United States
- Prior art keywords
- reservoir
- cutter
- projection
- sheet
- humidity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 title claims abstract description 9
- 230000004888 barrier function Effects 0.000 claims abstract description 14
- 230000009471 action Effects 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 12
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000004411 aluminium Substances 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 description 9
- 238000005520 cutting process Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 3
- 208000034693 Laceration Diseases 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
- B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
- B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
- B65D51/2842—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being provided with a preformed weakened line
- B65D51/285—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being provided with a preformed weakened line ruptured by a sharp element, e.g. a cutter or a piercer
Definitions
- the invention relates to the field of single-dose containers in which a substance is to be mixed at moment of use with a liquid.
- containers in particular single-dose containers, on which a capsule is fitted, the capsule being of various types: internally of the capsule there is a reservoir, having a breakable bottom, internally of which there is a cutting element which, following a pressure exerted thereon, causes the breakage of the breakable bottom.
- a substance is contained inside the reservoir, usually a powder or granules, which on rupture of the bottom falls into the container and is suspended in the liquid contained therein.
- the breakable bottom of the reservoir is connected to the remaining part of the reservoir by a circumferential line having a very much smaller thickness so as to be easily broken by exerting a little pressure on the cutting element.
- the thickness of the walls of the reservoir is usually comprised between 1 and 2 millimetres
- the circumferential line along which the cut is performed is of a thickness which, in order to allow an easy cutting operation, generally does not go above 0.15 mm. and is even less in some cases.
- the substances contained in the reservoir which are soluble in the liquid contained in the container and are dissolved in the liquid at moment of use, are generally sensitive to humidity both because of their physical nature (they are prone to clotting together to make unwanted lumps) or due to their chemical nature (their properties can be modified); this is often the reason why these preparations involve mixing the dry substance in the liquid only at moment of use.
- the materials the reservoirs containing the dry substance are made of are by their nature permeable to damp, although only by modest amounts; this permeability does not lead to significant consequences in the zones of the reservoir having greater wall thickness, as the time needed for migration of the humidity to those zones is very long; the phenomenon is, however, of considerable importance in the proximity of the circumferential line of the reservoir along which the cut is to be made, as the thickness of that line is extremely small and the time for migration of humidity through it is much less. This phenomenon leads to deterioration, over relatively short times, of the chemical-physical characteristics of the substance contained in the reservoir, or at least part of it.
- plastic materials have been used to make the reservoirs which materials have a lower permeability to humidity. But apart from the fact that this solution does not eliminate the problem, but only slows it down, these materials have characteristics that make them very difficult to break with normally-used cutters, and their use has been abandoned.
- a further solution which has been adopted is to put into the reservoir a greater than necessary quantity of the powder substance, so that as the deterioration thereof is progressive, even if a part of it deteriorates there will still be enough, and for a long enough time, for the aims of the preparation.
- This however is an expensive solution, and is not very precise in terms of doses effectively used.
- Another solution is to indicate a use-by date which takes account of the absorption times of the humidity through the circumferential line in the reservoir; this time limit is much more restricted than the actual degradation times of the substance. This is also rather an expensive solution.
- the main aim of the present invention is to obviate the drawbacks in the prior art, by providing a reservoir with a cutter that is easy to cut through and which has long permeability times with regard to humidity.
- An advantage of the present invention is that it provides a reservoir that can be used with existing containers without any need for modifications to the packaging line, and that is easy to construct.
- a further advantage of the invention is that it provides a reservoir which is impermeable to humidity over a long period of time both when the reservoir is free (it is an independent product) and when it is inserted in the container to constitute the definitive packaging.
- FIG. 1 is a section in vertical elevation of the reservoir
- FIG. 2 shows, in small scale, a vertical elevation, partially sectioned, of the reservoir of the invention applied on a capsule inserted on a container.
- 1 denotes a container having a mouth, at the end of a neck 2 , which is closed by a capsule 3 of known type.
- a reservoir 8 is afforded internally of the capsule 3 , which reservoir 8 has a breakable bottom 8 a and contains a cutter 9 ; the reservoir 8 is inserted sealedly in the mouth 2 of the container 1 .
- the substance to be inserted into the container at moment of use is located internally of the reservoir 8 , or internally of the cutter 9 (as illustrated in FIG. 2 ), if the cutter is internally hollow.
- the capsule is opened and a pressure is applied on the upper part of the cutter so that the end part of the cutter moves towards the bottom of the reservoir and cuts the breakable bottom along an easy-break line 8 b .
- the cutter has a cylindrical shape and exhibits a spout-shape, with the perimeter thereof being the inclined cutting edge of the element.
- a small cutting arc is included in the cutter, in particular at a zone of the cutter that is most distant from the bottom of the reservoir, which either does not cut or does not arrive (with the cutter at endrun position) at the bottom of the reservoir and cannot cut it. This is in order that the cut part of the reservoir does not detach completely and therefore does not fall into the underlying container.
- the reservoir 8 comprises a barrier element the chief characteristics of which are that it is easily removable, or cuttable, or in any case penetrable, by the cutter or by the cutting action thereof, and that it is impermeable to humidity.
- the barrier element is connected to the reservoir at a position which places it between the substance contained in the reservoir and the outside environment so that it can intercept any humidity which might migrate through the line 8 b from the container towards the inside of the reservoir.
- the outside environment will be represented by the inside of the container itself, and passage of humidity coming therefrom will be prevented.
- a rather simple way to create this barrier is to use a thin sheet 6 of multi-layer material comprising at least one metal layer and a plastic layer; from among the various known multilayer materials, a preferable choice for the barrier would be a material comprising at least one layer of aluminium, a metal which even in very thin sheets constitutes an, excellent barrier to humidity, and a layer of polyethylene, with functions that will be better explained herein below.
- the reservoir 8 comprises at least a closed-perimeter projection 5 , made in the external zone of the bottom of the reservoir which completely surrounds the line 8 b ; in particular, the projection 5 is annular and is afforded at the lower peripheral edge of the reservoir 8 .
- the projection 5 which is realised in a single piece with the reservoir during the forming thereof, defines a flat surface to an edge of which, represented by the perimeter of the projection 5 , the sheet 6 is heat-welded. This operation is made extremely easy because of the presence of the layer of polyethylene present in the sheet 6 .
- the bottom 8 a of the reservoir 8 is generally concave; as a consequence, when the sheet 6 is connected to the projection 5 , between the bottom 8 a and the sheet 6 , an empty zone is created, in which the sheet is free.
- connection points 5 a can be included, arranged internally of the perimeter of the projection 5 and projecting externalwards of the bottom 8 a of the reservoir in order that the terminal part thereof is coplanar with the flat surface defined by the projection 5 .
- the sheet 6 is thus heat-welded to the reservoir 8 not only at the projection 5 , but also at the connection points 5 a , and the possibility of an accidental laceration of the sheet is considerably reduced.
- the presence of the barrier sheet does not minimally influence the functioning of the cutter, which is perfectly able, with no appreciable additional force, to cut the breakable bottom of the reservoir 5 and the sheet 6 . Further, as happens with the bottom 8 a , the sheet 6 too is not cut completely, but a piece remains attached (corresponding to the non-cut part of the bottom) to the reservoir 5 , and does not fall into the underlying container, where the substance falls.
- the described reservoir can be used in all applications for which known reservoirs are used and, with respect to known reservoirs, exhibits the very considerable advantage of not allowing humidity originating from outside or from the container to reach the substance in the reservoir. Obtaining this advantage is also easy and economical and requires no modifications to present packaging lines inasmuch as the reservoir is supplied to the packaging lines already structured as described herein and can be inserted in a container in the same way as traditional reservoirs.
- the person packing the reservoir containing the powders is different from the one who is packaging the final product by insertion of the reservoir in the container, and given that the reservoir protects the powders contained therein from possible infiltrations of humidity present in the outside environment, the risk of infiltration of humidity over a possibly quite long period is prevented when it is inserted in the container.
- the barrier element can be realised in other ways: for example, the sheet 6 could be connected internally of the reservoir during the forming process of the reservoir itself, or the easy-break line 8 b could be covered with a sheet of material, obviously a biocompatible material which does not react in any way either with the substance contained in the reservoir 5 or with the liquid contained in the container, which material remains in the plastic state and can easily be crossed by the cutter.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Package Specialized In Special Use (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Accessories For Mixers (AREA)
- Closures For Containers (AREA)
- Crushing And Pulverization Processes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IT2005/000405 WO2007010560A1 (en) | 2005-07-15 | 2005-07-15 | A reservoir with a cutter for substances to be mixed with liquids at moment of use, in particular for single-dose containers |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080202949A1 true US20080202949A1 (en) | 2008-08-28 |
Family
ID=35811628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/915,507 Abandoned US20080202949A1 (en) | 2005-07-15 | 2005-07-15 | Reservoir With a Cutter for Substances to be Mixed With Liquids at Moment of Use in Particular for Single-Dose Containers |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080202949A1 (es) |
EP (1) | EP1904381B1 (es) |
AT (1) | ATE420037T1 (es) |
BR (1) | BRPI0520210A2 (es) |
CA (1) | CA2608978A1 (es) |
DE (1) | DE602005012321D1 (es) |
ES (1) | ES2320019T3 (es) |
MX (1) | MX2007015063A (es) |
WO (1) | WO2007010560A1 (es) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100301002A1 (en) * | 2007-05-14 | 2010-12-02 | Marguerite Deperrois | container cap forming a reservoir for additive |
WO2010143617A1 (ja) * | 2009-06-10 | 2010-12-16 | 株式会社ウイスマー | 混合用二重容器 |
US20150203261A1 (en) * | 2012-02-09 | 2015-07-23 | Su-Jae Lee | Accommodating Device for Different Types of Material |
US20170253399A1 (en) * | 2014-08-29 | 2017-09-07 | Zhejiang Canal Food Co., Ltd. | Bottle Cap with Additive Supply Structure |
WO2018047013A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
WO2018047002A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
US20180362229A1 (en) * | 2015-12-23 | 2018-12-20 | Bormioli Pharma S.r.l. | Safety capsule for a container |
WO2019171174A2 (en) | 2018-03-07 | 2019-09-12 | St Ip Holding Ag | Combination compositions and therapies comprising 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione, and methods of making and using same |
WO2020058767A1 (en) | 2018-09-18 | 2020-03-26 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2- dithiole-3-thiones |
IT201900005112A1 (it) * | 2019-04-04 | 2020-10-04 | Sacmi | Capsula di chiusura per un contenitore |
WO2021186244A1 (en) | 2020-03-16 | 2021-09-23 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2-dithiole-3-thiones |
WO2021205233A2 (en) | 2020-04-08 | 2021-10-14 | St Ip Holding Ag | Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione |
US11198546B2 (en) * | 2017-01-26 | 2021-12-14 | Bnova | Cartridge to dispense a product in a container |
US11505375B2 (en) * | 2018-02-08 | 2022-11-22 | Bormioli Pharma S.p.A. | Closure of a container |
US11591144B2 (en) * | 2018-02-08 | 2023-02-28 | Bormioli Pharma S.p.A. | Capsule for closing a container |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2921908A1 (fr) * | 2007-10-08 | 2009-04-10 | Plastrade | Bouchon predose a visser et a percusion manuelle 2 pieces "screwpush" |
ITMI20080047A1 (it) * | 2008-01-14 | 2009-07-15 | Liteco Srl | Tappo dosatore in materiale plastico ad alta densita' munito di un sigillo di chiusura |
EP2154081A1 (en) * | 2008-08-06 | 2010-02-17 | Merit 90 S.n.c. di Francesco Lamoure & C. | Closing device for medical containers and the like including a temporary receptacle |
CL2008003761A1 (es) | 2008-12-17 | 2010-01-04 | The Tapa Company S A | Sistema de cierre para envases del tipo botella que permite dispensar hacia el interior un aditivo mantenido aislado, formado por una cubierta alargada con su extremo cerrado, un actuador con una pieza deslizante conica con una perforacion vertical, un cuerpo con un compartimiento central con un faldon hilado, y un contenedor con el aditivo. |
EP2239205A1 (fr) * | 2009-04-09 | 2010-10-13 | Société Plastrade | Bouchon doseur |
IT1402774B1 (it) * | 2010-11-12 | 2013-09-18 | Punto Pack S R L | Capsula perfezionata per sostanze da miscelare al momento dell'uso |
ITMI20111453A1 (it) * | 2011-07-29 | 2013-01-30 | S M P S R L | Dispositivo con serbatoio di contenimento di una prima sostanza per la chiusura di un flacone di contenimento di una seconda sostanza da mantenere separata dalla prima sostanza fino al momento della miscelazione con essa |
IT201600097495A1 (it) * | 2016-09-28 | 2018-03-28 | Bormioli Pharma S R L | Capsula con struttura di contenimento e rilascio di un prodotto |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US3920141A (en) * | 1974-01-08 | 1975-11-18 | Tiziano Bojardi | Stopper for containers, especially bottles and flasks |
US5038951A (en) * | 1988-04-18 | 1991-08-13 | Napoleone Rizzardi | Closure for monodose bottles and the like, comprising a reservoir provided with a breakable bottom |
US5388690A (en) * | 1992-11-27 | 1995-02-14 | Ibsa Institut Biochimique S.A. | Proportioning device for extemporaneous multidose syrups |
US5927549A (en) * | 1998-03-20 | 1999-07-27 | Aptargroup, Inc. | Dispensing structure with frangible membrane for separating two products |
US6148996A (en) * | 1997-02-28 | 2000-11-21 | Bormioli Rocco & Figlio S.P.A. | Package for keeping products separate before use |
US6367622B1 (en) * | 2000-08-01 | 2002-04-09 | Lily Hsu | Container with separate storage spaces |
US6705462B2 (en) * | 2001-01-23 | 2004-03-16 | Mikuni Corporation | Cap for contents mixer |
US6766903B1 (en) * | 2003-09-05 | 2004-07-27 | Li-Li Yehhsu | Container having separate storage chambers |
US7325676B2 (en) * | 2003-07-11 | 2008-02-05 | Jose Luis Galaz Rodriguez | Container for containing two different separate products and mixing them |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1010856B (it) * | 1974-03-29 | 1977-01-20 | Capsulit Srl | Perfezionamenti alle chiusure per bottiglie e simili del tipo rac chiudente un serbatoio a fondo frangibile |
GB2208640B (en) * | 1987-02-12 | 1991-06-05 | Ici Plc | Method for introducing additive into a closed container |
DE19950884A1 (de) * | 1999-10-22 | 2001-04-26 | Wella Ag | Kombinationsverpackung |
AUPR230100A0 (en) * | 2000-12-22 | 2001-01-25 | Southcorp Australia Pty Ltd | An improved closure, capsule and dispensing system |
HRPK20030525B1 (en) * | 2003-06-26 | 2004-08-31 | Cedevita D O O | Bottle cap - container and dosage device of ingredients for quick preparation of beverages |
-
2005
- 2005-07-15 CA CA002608978A patent/CA2608978A1/en not_active Abandoned
- 2005-07-15 EP EP05778753A patent/EP1904381B1/en active Active
- 2005-07-15 MX MX2007015063A patent/MX2007015063A/es unknown
- 2005-07-15 AT AT05778753T patent/ATE420037T1/de not_active IP Right Cessation
- 2005-07-15 BR BRPI0520210-8A patent/BRPI0520210A2/pt not_active Application Discontinuation
- 2005-07-15 US US11/915,507 patent/US20080202949A1/en not_active Abandoned
- 2005-07-15 WO PCT/IT2005/000405 patent/WO2007010560A1/en not_active Application Discontinuation
- 2005-07-15 DE DE602005012321T patent/DE602005012321D1/de active Active
- 2005-07-15 ES ES05778753T patent/ES2320019T3/es active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920141A (en) * | 1974-01-08 | 1975-11-18 | Tiziano Bojardi | Stopper for containers, especially bottles and flasks |
US5038951A (en) * | 1988-04-18 | 1991-08-13 | Napoleone Rizzardi | Closure for monodose bottles and the like, comprising a reservoir provided with a breakable bottom |
US5388690A (en) * | 1992-11-27 | 1995-02-14 | Ibsa Institut Biochimique S.A. | Proportioning device for extemporaneous multidose syrups |
US6148996A (en) * | 1997-02-28 | 2000-11-21 | Bormioli Rocco & Figlio S.P.A. | Package for keeping products separate before use |
US5927549A (en) * | 1998-03-20 | 1999-07-27 | Aptargroup, Inc. | Dispensing structure with frangible membrane for separating two products |
US6367622B1 (en) * | 2000-08-01 | 2002-04-09 | Lily Hsu | Container with separate storage spaces |
US6705462B2 (en) * | 2001-01-23 | 2004-03-16 | Mikuni Corporation | Cap for contents mixer |
US7325676B2 (en) * | 2003-07-11 | 2008-02-05 | Jose Luis Galaz Rodriguez | Container for containing two different separate products and mixing them |
US6766903B1 (en) * | 2003-09-05 | 2004-07-27 | Li-Li Yehhsu | Container having separate storage chambers |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100301002A1 (en) * | 2007-05-14 | 2010-12-02 | Marguerite Deperrois | container cap forming a reservoir for additive |
WO2010143617A1 (ja) * | 2009-06-10 | 2010-12-16 | 株式会社ウイスマー | 混合用二重容器 |
US20150203261A1 (en) * | 2012-02-09 | 2015-07-23 | Su-Jae Lee | Accommodating Device for Different Types of Material |
US9650190B2 (en) * | 2012-02-09 | 2017-05-16 | Su-Jae Lee | Accommodating device for different types of material |
US20170253399A1 (en) * | 2014-08-29 | 2017-09-07 | Zhejiang Canal Food Co., Ltd. | Bottle Cap with Additive Supply Structure |
US10882672B2 (en) * | 2015-12-23 | 2021-01-05 | Bormioli Pharma S.p.A. | Safety capsule for a container |
US20180362229A1 (en) * | 2015-12-23 | 2018-12-20 | Bormioli Pharma S.r.l. | Safety capsule for a container |
US11535434B2 (en) | 2015-12-23 | 2022-12-27 | Bormioli Pharma S.p.A. | Safety capsule for a container |
WO2018047013A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
WO2018047002A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
US11198546B2 (en) * | 2017-01-26 | 2021-12-14 | Bnova | Cartridge to dispense a product in a container |
US11505375B2 (en) * | 2018-02-08 | 2022-11-22 | Bormioli Pharma S.p.A. | Closure of a container |
US11591144B2 (en) * | 2018-02-08 | 2023-02-28 | Bormioli Pharma S.p.A. | Capsule for closing a container |
WO2019171174A2 (en) | 2018-03-07 | 2019-09-12 | St Ip Holding Ag | Combination compositions and therapies comprising 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione, and methods of making and using same |
WO2020058767A1 (en) | 2018-09-18 | 2020-03-26 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2- dithiole-3-thiones |
WO2020201980A1 (en) * | 2019-04-04 | 2020-10-08 | Sacmi Cooperativa Meccanici Imola Societa' Cooperativa | Closing cap for a container |
IT201900005112A1 (it) * | 2019-04-04 | 2020-10-04 | Sacmi | Capsula di chiusura per un contenitore |
CN113853342A (zh) * | 2019-04-04 | 2021-12-28 | 萨克米伊莫拉机械合作社合作公司 | 用于容器的封闭盖 |
WO2021186244A1 (en) | 2020-03-16 | 2021-09-23 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2-dithiole-3-thiones |
WO2021205233A2 (en) | 2020-04-08 | 2021-10-14 | St Ip Holding Ag | Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione |
Also Published As
Publication number | Publication date |
---|---|
EP1904381A1 (en) | 2008-04-02 |
BRPI0520210A2 (pt) | 2009-04-22 |
EP1904381B1 (en) | 2009-01-07 |
WO2007010560A1 (en) | 2007-01-25 |
DE602005012321D1 (de) | 2009-02-26 |
ES2320019T3 (es) | 2009-05-18 |
CA2608978A1 (en) | 2007-01-25 |
MX2007015063A (es) | 2008-01-28 |
ATE420037T1 (de) | 2009-01-15 |
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