US20070027464A1 - Device for resecting spinal tissue - Google Patents
Device for resecting spinal tissue Download PDFInfo
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- US20070027464A1 US20070027464A1 US11/461,036 US46103606A US2007027464A1 US 20070027464 A1 US20070027464 A1 US 20070027464A1 US 46103606 A US46103606 A US 46103606A US 2007027464 A1 US2007027464 A1 US 2007027464A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1662—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body
- A61B17/1671—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body for the spine
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- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
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- A61B17/1604—Chisels; Rongeurs; Punches; Stamps
- A61B17/1606—Chisels; Rongeurs; Punches; Stamps of forceps type, i.e. having two jaw elements moving relative to each other
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
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Definitions
- the present invention relates generally to minimally invasive methods, devices and systems for treating spinal disorders using imaging guidance. More particularly, the present invention relates to devices and methods to reduce stenosis and increase the cross-sectional area of the spinal canal available for the spinal cord. Still more particularly, the present invention relates to devices and methods to percutaneously excise portions of an enlarged ligamentum flavum.
- the present invention relates generally to a minimally invasive method, device and system for treating spinal disorders using imaging guidance. More particularly, this invention relates to devices and tools that provide a percutaneous portal to tissues in a region of interest. Still more particularly, this invention relates to devices and tools that provide percutaneous portals to tissue through bone.
- the vertebral column (spine, spinal column, backbone) forms the main part of the axial skeleton, provides a strong yet flexible support for the head and body, and protects the spinal cord disposed in the vertebral canal, which is formed within the vertebral column.
- the vertebral column comprises a stack of vertebrae with an intervertebral disc between adjacent vertebrae. The vertebrae are stabilized by muscles and ligaments that hold the vertebrae in place and limit the movements of the vertebrae.
- each vertebra 10 includes a vertebral body 12 that supports a vertebral arch 14 .
- a median plane 210 generally divides vertebra 10 into two substantially equal lateral sides.
- Vertical body 12 has the general shape of a short cylinder and is anterior to the vertebral arch 14 .
- the vertebral arch 14 together with vertebral body 12 encloses a space termed the vertebral foramen 15 .
- the succession of vertebral foramen 15 in adjacent vertebrae 10 along the vertebral column define the vertebral canal (spinal canal), which contains the spinal cord.
- Vertebral arch 14 is formed by two pedicles 24 which project posteriorly to meet two laminae 16 .
- the two laminae 16 meet posteriomedially to form the spinous process 18 .
- six processes arise.
- Two transverse processes 20 project posterolaterally
- two superior articular processes 22 project generally superiorly and are positioned superior to two inferior articular processes 25 that generally project inferiorly.
- the vertebral foramen 15 is generally an oval shaped space that contains and protects the spinal cord 28 .
- Spinal cord 28 comprises a plurality of nerves 34 surrounded by cerebrospinal fluid (CSF) and an outermost sheath/membrane called the dural sac 32 .
- CSF cerebrospinal fluid
- the CSF filled dural sac 32 containing nerves 34 is relatively compressible.
- Posterior to the spinal cord 28 within vertebral foramen 15 is the ligamentum flavum 26 .
- Laminae 16 of adjacent vertebral arches 14 in the vertebral column are joined by the relatively broad, elastic ligamentum flavum 26 .
- Lumbar spinal stenosis is often defined as a dural sac cross-sectional area less than 100 mm 2 or an anteroposterior (AP) dimension of the canal of less than 10-12 mm for an average male.
- AP anteroposterior
- the source of many cases of lumbar spinal stenosis is thickening of the ligamentum flavum.
- Spinal stenosis may also be caused by subluxation, facet joint hypertrophy, osteophyte formation, underdevelopment of spinal canal, spondylosis deformans, degenerative intervertebral discs, degenerative spondylolisthesis, degenerative arthritis, ossification of the vertebral accessory ligaments and the like.
- a less common cause of spinal stenosis which usually affects patients with morbid obesity or patients on oral corticosteroids, is excess fat in the epidural space.
- the excessive epidural fat compresses the dural sac, nerve roots and blood vessels contained therein and resulting in back and leg pain and weakness and numbness of the legs.
- Spinal stenosis may also affect the cervical and, less commonly, the thoracic spine.
- an incision is made in the back and the muscles and supporting structures are stripped away from the spine, exposing the posterior aspect of the vertebral column.
- the thickened ligamentum flavum is then exposed by removal of a portion of the vertebral arch, often at the laminae, covering the back of the spinal canal (laminectomy).
- the thickened ligamentum flavum ligament can then be excised by sharp dissection with a scalpel or punching instruments such as a Kerison punch that is used to remove small chips of tissue.
- the procedure is performed under general anesthesia. Patients are usually admitted to the hospital for approximately five to seven days depending on the age and overall condition of the patient. Patients usually require between six weeks and three months to recover from the procedure. Further, many patients need extended therapy at a rehabilitation facility to regain enough mobility to live independently.
- Minimally invasive techniques offer the potential for less post-operative pain and faster recovery compared to traditional open surgery.
- Percutaneous interventional spinal procedures can be performed with local anesthesia, thereby sparing the patient the risks and recovery time required with general anesthesia.
- Microdiscectomy is performed by making a small incision in the skin and deep tissues to create a portal to the spine. A microscope is then used to aid in the dissection of the adjacent structures prior to discectomy. The recovery for this procedure is much shorter than traditional open discectomies.
- Percutaneous discectomy devices with fluoroscopic guidance have been used successfully to treat disorders of the disc but not to treat spinal stenosis or the ligamentum flavum directly.
- Arthroscopy or direct visualization of the spinal structures using a catheter or optical system have also been proposed to treat disorders of the spine including spinal stenosis, however these devices still use miniaturized standard surgical instruments and direct visualization of the spine similar to open surgical procedures. These devices and techniques are limited by the small size of the canal and these operations are difficult to perform and master. In addition, these procedures are painful and often require general anesthesia. Further, the arthroscopy procedures are time consuming and the fiber optic systems are expensive to purchase and maintain.
- any surgery regardless of whether open or percutaneous, includes a risk of damage to the nerves of the spinal cord.
- the device comprises an outer sleeve.
- the device comprises an inner tubular member slidingly received within the outer sleeve.
- the device comprises a cutting head connected to a distal end of the inner tubular, wherein the cutting head comprises at least three arms extending axially from the inner tubular.
- the device has an open position in which the cutting head extends from the outer sleeve, and a closed position in which the cutting head is at least partially disposed within the sleeve.
- the method comprises the step of positioning a tissue excision device adjacent the region of interest, wherein the tissue excision device comprises an outer sleeve, an inner tubular member slidingly received within the outer sleeve, and a cutting head connected to a distal end of the inner tubular, the cutting head including at least three arms extending axially from the inner tubular.
- the method comprises the step of opening the tissue excision device by extending the cutting head from the outer sleeve. Further, the method comprises the step of inserting the tissue excision device into tissue in the region of interest. Still further, the method comprises the step of closing the tissue excision device by advancing the outer sleeve over the cutting head. Moreover, the method comprises the step of retracting the tissue excision device from the tissue in the region of interest.
- kits for performing a procedure on a spine including an epidural space containing a dural sac.
- the kit comprises an insertion member for accessing the epidural space.
- the kit comprises a volume of a contrast medium adapted to be inserted into the epidural space by the insertion member and expanded so as to compress a portion of the thecal sac and provide a safety zone within the epidural space.
- the kit comprises a tissue excision device comprising an outer sleeve, an inner tubular member slidingly received within the outer sleeve, a cutting head connected to a distal end of the inner tubular, wherein the cutting head comprises at least three arms extending axially from the inner tubular.
- FIG. 1 is cross-section of the spine viewed from the space between two vertebrae, showing the upper surface of one vertebra and the spinal canal with the dural sac and a normal (un-stenosed) ligamentum flavum therein;
- FIG. 2 is an illustration of the same section as FIG. 1 , showing the spinal canal with the dural sac and a thickened ligamentum flavum therein;
- FIG. 3 is an enlarged cross-section of a vertebral foramen, showing a safety zone created by compression of the dural sac;
- FIG. 4 is the cross-section of FIG. 3 , showing a tissue excision tool positioned in the ligamentum flavum;
- FIGS. 5-9 are a series of illustrations showing tissue excision by a tissue-excision tool constructed in accordance with a first embodiment of the invention.
- FIGS. 10-14 are a series of illustrations showing tissue excision by a tissue-excision tool constructed in accordance with a second embodiment of the invention.
- FIGS. 15 and 17 are sequential illustrations showing removal of tissue from a tissue-excision tool by a tissue-removal device constructed in accordance with an embodiment of the invention
- FIGS. 16 and 18 are end views of the tissue-removal device of FIGS. 15 and 17 , respectively;
- FIG. 19 shows an alternative embodiment of a grasping needle with a corkscrew shape
- FIG. 20 is a perspective view of a tissue-excision tool constructed in accordance with a third embodiment of the invention.
- FIGS. 21 and 22 are enlarged cross-sectional and perspective views, respectively, of the grasping device of FIG. 20 in its retracted position;
- FIGS. 23 and 24 are enlarged cross-sectional and perspective views, respectively, of the grasping device of FIG. 20 in its extended position;
- FIG. 25 is a schematic illustration of one embodiment of a double-ended ligament anchor being deployed in a ligamentum flavum
- FIG. 26 shows the device of FIG. 25 after full deployment
- FIG. 27 is a perspective view of an entire tool constructed in accordance with preferred embodiments.
- FIG. 28 is an enlarged cross-sectional view of the distal tip of the tool of FIG. 27 with the aperture partially opened;
- FIG. 29 is a cross-sectional view of the handle end of the tool of FIG. 27 ;
- FIG. 30 is cross-section of another embodiment of a tissue-removal device
- FIG. 31 is a perspective view of the distal portion of an embodiment of a tissue excision device in an open position
- FIG. 32 is an end-view of the tissue excision device of FIG. 31 ;
- FIG. 33 is a perspective view of the tissue excision device of FIG. 31 transitioning from the open position to the closed position;
- FIGS. 34 and 35 are sequential schematic illustrations showing the excision of tissue by the tissue excision tool illustrated in FIG. 31 .
- the x-, y-, and z-axes are shown in FIGS. 1 and 3 to aid in understanding the descriptions that follow.
- the x-, y-, and z-axes have been assigned as follows.
- the x-axis is perpendicular to the longitudinal axis of the vertebral column and perpendicular to the coronal/frontal plane (i.e., x-axis defines anterior vs. posterior relationships).
- the y-axis runs substantially parallel to the vertebral column and perpendicular to the transverse plane (i.e., y-axis defines superior vs. inferior relationships).
- the z-axis is perpendicular to the longitudinal axis of the vertebral column and perpendicular to the median/midsagittal plane (i.e., z-axis defines the lateral right and left sides of body parts).
- the set of coordinate axes (x-, y-, and z-axes) are consistently maintained throughout although different views of vertebrae and the spinal column may be presented.
- the median/midsagittal plane passes from the top to the bottom of the body and separates the left and the right sides of the body, and the spine, into substantially equal halves (e.g., two substantially equal lateral sides).
- the frontal/coronal plane essentially separates the body into the forward (anterior) half and the back (posterior) half, and is perpendicular to the median plane.
- the transverse plane is perpendicular to both the median plane and coronal plane and is the plane which divides the body into an upper and a lower half.
- vertebral foramen 15 contains a portion of the ligamentum flavum 26 , spinal cord 28 , and an epidural space 27 between ligamentum flavum 26 and spinal cord 28 .
- Spinal cord 28 comprises a plurality of nerves 34 surrounded by cerebrospinal fluid (CSF) contained within dural sac 32 .
- Nerves 34 normally comprise only a small proportion of the dural sac 32 volume.
- CSF filled dural sac 32 is somewhat locally compressible, as localized pressure causes the CSF to flow to adjacent portions of the dural sac.
- Epidural space 27 is typically filled with blood vessels and fat.
- the posterior border of the normal epidural space 27 generally defined by the ligamentum flavum 26 , which is shown in its normal, non-thickened state in FIG. 1 .
- FIG. 2 illustrates a case of spinal stenosis resulting from a thickened ligamentum flavum 26 .
- vertebral foramen 15 is defined and surrounded by the relatively rigid bone its volume is substantially constant.
- thickening of ligamentum flavum 26 within vertebral foramen 15 can eventually result in compression of spinal cord 28 .
- the thickened ligamentum flavum 26 may exert a compressive force on the posterior surface of dural sleeve 32 .
- thickening of ligamentum flavum 26 may compress the blood vessels and fat occupying epidural space 27 .
- Compression of spinal cord 28 may result in low back pain as well as pain or abnormal sensations in the legs. Further, compression of the blood vessels in the epidural space 27 that houses the nerves of the cauda equina may result in ischemic pain termed spinal claudication.
- a thickened or enlarged ligamentum flavum 26 In order to relieve the symptoms associated with a thickened or enlarged ligamentum flavum 26 , methods, techniques, and devices described herein may be employed to reduce the compressive forces exerted by the thickened ligamentum flavum on spinal cord 28 and the blood vessels in epidural space 27 (ergo, decompress spinal cord 28 and blood vessels in epidural space 27 ).
- compressive forces exerted by the thickened/enlarged ligamentum flavum 26 may be reduced by embodiments of a minimally invasive ligament decompression (MILD) procedure described herein.
- the MILD procedure may be performed percutaneously to reduce the size of ligamentum flavum 26 by excising portions of ligamentum flavum 26 .
- the ligamentum flavum 26 is accessed, cut and removed ipsilaterally (i.e., on the same side of vertebral arch 14 ) by a percutaneous cranial-caudal approach.
- ILAMP Ipsilateral Approach MILD Procedure
- ligamentum flavum 26 is posteriorly apposed to spinal cord 28 .
- placement of tools within ligamentum flavum 26 to excise portions of ligamentum flavum 26 creates a risk of for inadvertent damage to the spinal cord 28 , dural sac 32 , and/or nerves 34 .
- a gap is advantageously created between ligamentum flavum 26 and spinal cold 28 to provide a safety zone between ligamentum flavum 26 and spinal cord 28 .
- FIG. 3 illustrates an enlarged cross-sectional view of a vertebral foramen 15 within a vertebra.
- Vertebral foramen 15 includes epidural space 27 and spinal cord 28 containing nerves 34 and CSF within dural sac 32 .
- a thickened/enlarged ligamentum flavum 26 extends into vertebral foramen 15 .
- a safety zone 40 is created between ligamentum flavum 26 and dural sac 32 .
- spinal cord 28 comprises nerves 34 surrounded by CSF and is contained within dural sac 32 . Since more than 90% of the volume of dural sac 32 in the lumbar region is filled by CSF, dural sac 32 is highly compressible. Thus, even when stenosis is causing compression of spinal cord 28 , in most cases it is possible to temporarily compress spinal cord 28 further. Thus, according to preferred embodiments, dural sac 32 is further compressed in the region of interest by injecting a fluid into epidural space 27 to create safety zone 40 .
- safety zone 40 The presence of the injected fluid comprising safety zone 40 gently applies an additional compressive force to the outer surface of dural sac 32 so that at least a portion of the CSF within dural sac 32 is forced out of dural sac 32 in the region of interest, resulting in safety zone 40 between dural sac 32 and ligamentum flavum 26 .
- dural sac 32 is compressed by injecting a standard radio-opaque non-ionic myelographic contrast medium or other imagable or non-imagable medium into epidural space 27 in the region of interest. This is preferably accomplished with a percutaneous injection. Sufficient injectable fluid is preferably injected to displace the CSF out of the region of interest and compress dural sac 32 to at least a desired degree. The injected medium is preferably substantially contained within the confines of epidural space 27 extending to the margins of the dural sac 32 .
- the epidural space is substantially watertight and the fatty tissues and vascularization in epidural space 27 , combined with the viscous properties of the preferred fluids, serve to substantially maintain the injected medium in the desired region of interest.
- This novel method for protecting spinal cord 28 column may be referred to hereinafter as “contrast-guided dural protection.”
- a tool 100 such as the tissue excision devices and tissue retraction devices described below, may be inserted into the ligamentum flavum 26 , as illustrated in FIG. 4 .
- Tool 100 may comprise any suitable device, tool, or instrument for relieving stenosis caused by the thickened/enlarged ligamentum flavum 26 including without limitation, embodiments of tissue excision devices and tissue retraction devices described in more detail below.
- tool 100 is positioned in the ligamentum flavum 26 on the opposite side of median plane 210 as tool 100 percutaneously accesses the body, such that tool 100 crosses median plane 210 .
- tool 100 is inserted and positioned in the ligamentum flavum 26 on the same side (ipsilateral) of median plane 210 as tool 100 percutaneously accesses the body, such that tool 100 does not cross median plane 210 .
- the presence of safety zone 40 reduces the likelihood that dural sac 32 will be damaged, even if the tool breaks through the anterior surface of ligamentum flavum 26 .
- a fluoroscopic window of access is defined by the inferior margin of the lamina (contra lateral to the point of instrument entry in the soft tissues) and the dorsal margin of the contrast material that defines the epidural space.
- This FWA is roughly orthogonal to the long axis of the cutting instrument, which parallels the inferior surface of the lamina as in FIG. 4 .
- the fluoroscopic plane of projection is preferably but not necessarily oriented 20-40 degrees from normal (AP projection).
- the spine can be imaged using any suitable technology, including without limitation, 2D fluoroscopy, 3D fluoroscopy, CT, MRI, ultrasound or with direct visualization with fiber optic or microsurgical techniques. Stereotactic or computerized image fusion techniques are also suitable. Fluoroscopy is currently particularly well-suited to the techniques disclosed herein. Fluoroscopic equipment is safe and easy to use, readily available in most medical facilities, relatively inexpensive. In a typical procedure, using direct biplane fluoroscopic guidance and local anesthesia, epidural space 27 is accessed for injection of contrast media adjacent to the surgical site.
- the safety zone created by the present contrast-guided dural compression techniques can reduce the risk of damage to the spinal cord during procedures to remove or displace portions of the ligamentum flavum and/or laminae in order to treat spinal stenosis.
- the injected medium can be provided as a re-absorbable water-soluble gel, so as to better localize safety zone 40 at the site of surgery and reduce leakage of this protective layer from the vertebral/spinal canal.
- An injectable gel is a significant improvement on prior epidural injection techniques.
- the gel is preferably substantially more viscid than conventional contrast media and the relatively viscid and/or viscous gel preferably tends to remain localized at the desired site of treatment as it does not spread as much as standard liquid contrast media that are used in epidurography. This may result in more uniform compression of dural sac 32 and less leakage of contrast out of the vertebral/spinal canal.
- preferred embodiments of the gel are re-absorbed more slowly than conventional contrast media, allowing for better visualization during the course of the surgical procedure.
- a contrast agent can be included in the gel itself, so that the entire gel mass is imagable.
- an amount of contrast can be injected first, followed by the desired amount of gel, or an amount of gel can be injected first, followed by the desired amount of contrast.
- the contrast agent is captured on the surface of the expanding gel mass, so that the periphery of the mass is imagable.
- any standard hydrophilic-lipophilic block copolymer (Pluronic) gel such as are known in the art would be suitable and other gels may be used as the injectable medium.
- the gel preferably has an inert base.
- the gel material is liquid at ambient temperatures and can be injected through a small bore (such as a 27 gauge needle).
- the gel then preferably becomes viscous when warmed to body temperature after being injected.
- the viscosity of the gel can be adjusted through the specifics of the preparation.
- the gel or other fluid is preferably sufficiently viscid or viscous at body temperature to compress and protect the thecal sac in the manner described above and to remain sufficiently present in the region of interest for at least about 30 minutes.
- the injected gel attains a viscosity that is two, three, six or even ten times that of the fluids that are typically used for epidurograms.
- the injected medium undergoes a reversible change in viscosity when warmed to body temperature so that it can be injected as a low-viscosity fluid, thicken upon injection into the patient, and be returned to its low-viscosity state by cooling.
- the injected medium is injected as desired and thickens upon warming, but can be removed by contacting it with a heat removal device, such as an aspirator that has been provided with a cooled tip.
- a heat removal device such as an aspirator that has been provided with a cooled tip.
- a suitable contrast medium having the desired properties is Omnipaque® 240 available from Nycomed, New York, which is a commercially available non-ionic iodinated myelographic contrast medium.
- Other suitable injectable media will be known to those skilled in the art. Because of the proximity to spinal cord 28 and spinal nerves 34 , it is preferred not to use ionic media in the injectable medium. The preferred compositions are reabsorbed relatively rapidly after the procedure. Thus any residual gel compression on dural sac 32 after the MILD procedure dissipates relatively quickly. For example, in preferred embodiments, the gel would have sufficient viscosity to compress dural sac 32 for thirty minutes, and sufficient degradability to be substantially reabsorbed within approximately two hours.
- the injected contrast medium further may further include one or more bioactive agents.
- bioactive agents such as those used in epidural steroid injection (e.g. Depo medrol, Celestone Soluspan) may be added to the epidural gel to speed healing and reduce inflammation, scarring and adhesions.
- the gel preferably releases the steroid medication slowly and prolongs the anti-inflammatory effect, which can be extremely advantageous.
- Local anesthetic agents may also be added to the gel. This prolongs the duration of action of local anesthetic agents in the epidural space to prolong pain relief during epidural anesthesia.
- the gel may be formulated to slow the reabsorption of the gel.
- the present gels may also be used for epidural steroid injection and perineural blocks for management of acute and chronic spinal pain.
- Thrombin or other haemostatic agents can be added if desired, so as to reduce the risk of bleeding.
- the gel may also be used as a substitute for a blood patch if a CSF leak occurs.
- the gel may also be used as an alternative method to treat lumbar puncture complications such as post-lumbar puncture CSF leak or other causes of intracranial hypotension.
- the gel may be used to patch postoperative CSF leaks or dural tears. If the dural sac were inadvertently torn or cut, then gel could immediately serve to seal the site and prevent leakage of the cerebral spinal fluid.
- the margins of epidural space 27 are clearly demarcated by the injected medium and can be visualized radiographically if an imagable medium has been used.
- percutaneous procedures can now safely be performed on ligamentum flavum 26 and/or surrounding tissues without injuring dural sac 32 or nerves 34 and the spinal canal can be decompressed using any of several techniques. Suitable decompression techniques include removal of tissue from the ligamentum flavum, laminectomy, laminotomy, and ligament retraction and anchoring.
- ligamentum flavum 26 and/or lamina 16 are excised using a percutaneous tissue excision device or probe 100 , which may hereinafter be referred to as the MILD device.
- a percutaneous tissue excision device or probe 100 As shown schematically in FIG. 4 , a device 100 may be placed parallel to the posterior and lateral margin of the safety zone 40 with its tip in the ligamentum flavum 26 .
- Preferred embodiments of the present tissue excision devices and techniques can take several forms.
- the distal ends of the tools are described in detail.
- the construction of the proximal ends of the tools, and the means by which the various components disclosed herein are assembled and actuated, will be known and understood by those skilled in the art.
- device 100 maybe a coaxial excision system 50 with a sharpened or blunt tip that is placed obliquely into the thickened ligamentum flavum 26 posterior to safety zone 40 under fluoroscopic guidance.
- the needle is preferably placed parallel to the posterior margin of the canal.
- Excision system 50 is preferably manufactured from stainless steel, titanium or other suitable durable biocompatible material.
- an outer needle or cannula 51 has an opening or aperture 52 on one side that is closed during insertion by an inner occluding member 54 . Aperture 52 is readily visible under imaging guidance.
- inner occluding member 54 is removed or retracted so that it no longer closes aperture 52 ( FIG. 6 ).
- Aperture 52 is preferably oriented away from the epidural space so as to further protect the underlying structures from injury during the surgical procedure. If it was not already present in the tool, a tissue-engaging means 56 is inserted through outer needle 51 to aperture 52 so that it contacts adjacent tissue, e.g., the ligamentum flavum, via aperture 52 .
- Tissue-engaging means 56 may be a needle, hook, blade, tooth or the like, and preferably has at least one flexible barb or hook 58 attached to its shaft.
- the barb 58 or barbs may extend around approximately 120 degrees of the circumference of the shaft.
- Barbs 58 are preferably directed towards the proximal end of the tool.
- tissue-engaging means 56 When tissue-engaging means 56 is retracted slightly, barbs 58 allow it to engage a segment of tissue.
- the tissue sample engaged by tissue-engaging means 56 may be generally cylindrical or approximately hemispherical.
- inner occluding means 54 which is preferably provided with a sharpened distal edge, is advanced so that it cuts the engaged tissue section or sample loose from the surrounding tissue.
- occluding means 54 also functions as a cutting means in this embodiment.
- a cylindrical outer cutting element 60 may extended over outer needle 51 and used in place of occluding member 54 to excise the tissue sample.
- tissue-engaging needle 56 can be pulled back through outer needle 51 so that the segment of tissue can be retrieved and removed from the barbs ( FIG. 8 ). The process or engaging and resecting tissue may be repeated ( FIG. 9 ) until the canal is adequately decompressed.
- a tissue-engaging hook 64 can be used in place of needle 56 and an outer cutting member 60 can be used in place of inner occluding member 54 .
- Hook 64 may comprise a length of wire that has been bent through at least about 270°, more preferably through 315°, and still more preferably through about 405°.
- hook 64 may comprise NitinolTM, or any other resilient metal that can withstand repeated elastic deflections.
- hook 64 includes at least one barb 58 at its distal end.
- hook 64 is pre-configured in a curvilinear shape and is retained within tool 100 by outer cutting member 60 .
- hook 64 When cutting member 60 is retracted, the curved shape of hook 64 urges its outer end to extend outward through aperture 52 . If desired, hook 64 can be advanced toward the distal end of tool 100 , causing it to extend farther into the surrounding tissue. In some embodiments, hook 64 is provided with a camming surface 66 . Camming surface 66 beats on the edge of opening 52 as hook 64 is advance or retracted and thereby facilitates retraction and retention of hook 64 as it is retracted into the tool. In these embodiments, hook 64 may not extend through aperture 52 until it has been advanced sufficiently for camming surface 66 to clear the edge of the opening. Hook 64 may alternatively be used in conjunction with an inner occluding member 54 in the manner described above. As above, hook 64 can be used to retrieve the engaged tissue from the distal end of the tool.
- the tissue-engaging means may comprise a hook or tooth or the like that engages tissue via aperture 52 by being rotated about the tool axis.
- the tissue-engaging means could comprise a partial cylinder that is received in outer cannula 51 and has a serrated side edge. Such a device can be rotated via a connection with the tool handle or other proximal device. As the serrated edge traverses aperture 52 tissue protruding into the tool via the aperture is engaged by the edge, whereupon it can be resected and retrieved in the manner disclosed herein.
- the working tip of tool 100 remains within the ligamentum flavum and does not penetrate the safety zone 40 . Nonetheless, safety zone 40 is provided so that even an inadvertent penetration of the tool into the epidural space will not result in damage to the thecal sac.
- tissue-removal device such as that described below is preferably used to remove the tissue from the retrieval device between each excision.
- Each piece of tissue may be removed from barbs 58 by pushing tissue-engaging means 56 through an opening that is large enough to allow passage of the flexible barbs and supporting needle but smaller than the diameter of the excised tissue mass. This pushes the tissue up onto the shaft, where it can be removed with a slicing blade or the like or by sliding the tissue over the proximal end of the needle.
- needle 56 can be removed and re-inserted into the tool for external, manual tissue removal.
- approximately 8-10 cores or segments of tissue will be excised and pushed up the shaft towards the hub during the course of the procedure.
- a small blade can be used to split the tissue segment and thereby ease removal of the segment from the device.
- a blade for this purpose can be placed on the shaft of needle 56 proximal to the barbs.
- the tissue removal device may include a scraper 120 that includes a keyhole slot having a wide end 122 and a narrow end 124 .
- the tissue-engaging device with a mass of excised tissue 110 thereon can be retracted (pulled toward the proximal end of the tool) through wide end 122 of the slot and then re-inserted (pushed toward the distal end of the tool) through narrow end 124 of the slot.
- Narrow end 124 is large enough to allow passage of the barbed needle, but small enough to remove the tissue mass as the needle passes through.
- the removed tissue can exit the tool through an opening 113 in the tool body.
- the tissue removal device may be constructed such that tissue is removed from the tissue-engaging device by retracting the tissue-engaging device through narrow end 124 of the slot.
- narrow end 124 is large enough to allow passage of the shaft of the tissue-engaging device, but small enough to remove the tissue mass as the needle passes through.
- the tissue-engaging device is constructed of a tough material, the barbs or the like will cut through the tissue and/or deform and release the tissue.
- the removed tissue can exit the tool through an opening 113 in the tool body.
- an alternative mechanism for removing the tissue segment from needle 56 includes an adjustable aperture in a disc. After the tissue-bearing needle is pulled back through the aperture, the aperture is partially closed. Needle 56 and flexible hooks 58 then can pass through the partially closed aperture but the larger cylinder of tissue cannot. Thus the tissue segment is pushed back onto the shaft. The tissue segment can either be pulled off the proximal end of the shaft or cut off of it. A small blade may be placed just proximal to the barbs to help cut the tissue segment off the shaft.
- the variable aperture can formed by any suitable construction, including a pair of metal plates with matching edges that each define one half of a central opening. The two pieces may be held apart by springs. The aperture may be closed by pushing the two edges together. In other embodiments, this process can be mechanically automated by using a disc or plate with an opening that is adjustable by a variety of known techniques, including a slit screw assembly or flexible gaskets.
- embodiments of the grasping mechanism include but are not limited to: needles with flexible barbs, needles with rigid barbs, corkscrew-shaped needles, and/or retaining wires.
- the corkscrew-shaped needle shown in FIG. 19 works by screwing into the ligamentum flavum in the manner that a corkscrew is inserted in a cork. After the screw engages a segment of tissue, outer cutting element 60 slides over the needle, cutting a segment of tissue in a manner similar to that of the previous embodiment. In some embodiments, the cutting element can be rotated as it cuts.
- cannulated scalpel 51 houses a grasping device 70 that includes at least one pair of arcuate, closable arms 72 .
- Closable arms 72 may be constructed in any suitable manner.
- One technique for creating closable arms is to provide a slotted sleeve 74 , as shown.
- Slotted member 74 preferably comprises an elongate body 75 with at least one slot 76 that extends through its thickness but does not extend to either end of the body. Slot 76 is preferably parallel to the longitudinal axis of the sleeve.
- a strip 77 is defined, with strips 77 being joined at each end of sleeve 74 .
- each strip 77 be relatively small. In some embodiments, it may be desirable to construct slotted member 74 from a portion of a hollow tube or from a rectangular piece that has been curved around a longitudinal axis. The inner edge of each strip that lies along slot 76 forms an opposing edge 78 . The width of the piece is the total of the width of strips 77 and slot 76 .
- each strip 77 Advancing one end of sleeve 74 toward the other end of sleeve 74 causes each strip 77 to buckle or bend. If strips 77 are prevented from buckling inward or if they are predisposed to bend in the desired direction, they will bend outward, thereby forming arcuate arms 72 , which extend through aperture 52 of cannulated scalpel 51 , as shown in FIG. 21 . As they move away from the axis of body 75 , arms 72 move apart in a direction normal to the axis of body 75 . Likewise, moving the ends of sleeve 74 apart causes arms 72 to straighten and to move together and inward toward the axis of the device, as shown in FIG. 22 . As the arms straighten, opposing edges 78 close and a segment of tissue can be capture between them. Tissue within the grasping device may then be resected or anchored via the other mechanisms described herein.
- Closable arms 72 may include on their opposing edges 78 ridges, teeth, or other means to facilitate grasping of the tissue. In other embodiments, edges 78 may be sharpened, so as to excise a segment of tissue as they close. In these embodiments, closable arms 72 may also be used in conjunction with a hook, barbed needle, pincers or the like, which can in turn be used to retrieve the excised segment from the device.
- the tissue can be excised using a blade such as cutting element 60 above.
- the excised tissue can be removed from the inside of needle 51 using a tissue-engaging hook 64 or other suitable means.
- the process of extending and closing arms 72 , excising the tissue, and removing it from the device can be repeated until a desired amount of tissue has been removed.
- this cycle can be repeated without repositioning the device in the tissue.
- the tool can be rotated or repositioned as desired between excisions. It is possible to rotate or reposition the tool during an excision, but it is expected that this will not generally be preferred. Furthermore, it is expected that the steps of tissue excision and removal can be accomplished without breaching the surface of the ligament, i.e. without any part of the device entering the safety zone created by the injected fluid. Nonetheless, should the tool leave the working zone, the safety zone will reduce the risk of injury to the thecal sac.
- the spinal canal may also be enlarged by retracting the ligamentum flavum, either with or without concurrent resection.
- Retraction is preferably but not necessarily performed after dural compression has been used to provide a safety zone.
- the dural compression techniques described above have the effect of pressing the ligamentum flavum back out of the spinal canal and thereby making it easier to apply a restraining means thereto.
- a retraction device 90 as shown in FIG. 23 is used to retract and compress the thickened soft tissues around the posterior aspect of the spinal canal, thereby increasing the available space for the dural sac and nerves.
- retraction device 90 is a double-headed anchor that includes at least one distal retractable tissue-engaging member 91 and at least one proximal tissue-engaging member 92 , each of which are supported on a body 94 .
- Retraction device 90 is preferably constructed from an implantable, non-biodegradable material, such as titanium or stainless steel, but may alternatively be polymeric or any other, suitable material.
- body 94 is somewhat flexible.
- barbs 91 , 92 may comprise hooks, arms, teeth, clamps, or any other device capable of selectively engaging adjacent tissue. Barbs 91 , 92 may have any configuration that allows them to engage the ligamentum flavum and/or surrounding tissue. Similarly, barbs 91 , 92 may be covered, sheathed, pivotable, retractable, or otherwise able to be extended from a first position in which they do not engage adjacent tissue to a second position in which they can engage adjacent tissue.
- FIG. 23 shows schematically the distal and proximal retractable arms 91 , 92 of a preferred ligament anchor 90 .
- the proximal end of the anchor preferably includes a threaded connector 96 or other releasable mechanism that attaches to a support rod 100 .
- Ligament anchor 90 may be attached to a support shaft 112 and sheathed in a guide housing 114 .
- the distal and proximal barbs 91 , 92 are prevented by guide housing 114 from engaging surrounding tissue.
- Housing 102 is preferably a metal or durable plastic guide housing.
- the distal end of the device is preferably positioned in the ligamentum flavum under fluoroscopic guidance. If desired, an accessway through the lamina may be provided using an anchored cannula or the like.
- the device is held in position by support shaft 112 .
- Distal barbs 91 are unsheathed and optionally expanded by pulling back guide housing 102 , as shown in FIG. 23 .
- Distal barbs 91 are secured in the ligamentum flavum by pulling back on the support shaft 112 . With barbs 91 engaging the tissue, the ligamentum flavum is retracted posteriorly by pulling back on support shaft 112 .
- proximal barbs 92 are uncovered and expanded by retracting guide housing 114 , as shown in FIG. 24 .
- Barbs 92 are preferably positioned in the soft tissues 116 in the para-spinal region so that the device is firmly anchored behind the posterior elements of the spinal canal.
- support shaft 112 may be detached from body 94 as shown in FIG. 24 .
- the posterior margin 95 of the ligamentum flavum can be held in a retracted position, thereby expanding the canal. The procedure can then be repeated on adjacent portions of the ligamentum flavum until it is sufficiently retracted.
- proximal end of ligament anchor 90 may be adapted to engage the lamina. This may be accomplished by having the arm posterior to the lamina or by using the laminotomy and suturing the device to the lamina there. A knotted or knotless system or a suture plate can be used.
- a second embodiment of the present method uses a plurality of retraction devices 90 .
- the retraction device is inserted through one lamina in an oblique fashion, paralleling the opposite lamina. After the distal anchor is deployed, the retraction device is pulled back and across the ligamentum flavum, thereby decompressing the opposite lateral recess of the spinal canal. This is repeated on the opposite side.
- This same device can also be deployed with a direct approach to the lateral recess with a curved guide housing.
- retraction device 90 is describe above as a double-headed anchor, it will be understood that other devices can be used.
- sutures, barbed sutures, staples or the like can be used to fasten the ligament in a retracted position that reduces stenosis.
- a dural sac cross-sectional area less than 100 mm 2 or an anteroposterior (AP) dimension of the canal of less than 10-12 mm in an average male is typically considered relative spinal stenosis.
- a dural sac cross-sectional area less than 85 mm 2 in an average male is considered severe spinal stenosis.
- the present devices and techniques are anticipated to cause an increase in canal area of 25 mm 2 per anchor or 50 mm 2 total.
- the cross-sectional area of the dural sac can be increased by 10 mm 2 , and in some instances by as much as 20 mm 2 or even 30 mm 2 .
- the present invention can result in an increase of the anteroposterior dimension of the canal by 1 to 2 mm and in some instances by as much as 4 or 6 mm.
- the actual amount by which the cross-sectional area of the thecal sac and/or the anteroposterior dimension of the canal are increased will depend on the size and age of the patient and the degree of stenosis and can be adjusted by the degree of retraction of the ligament.
- the minimally invasive ligament decompression (MILD) devices and techniques described herein allow spinal decompression to be performed percutaneously, avoiding the pain and risk associated with open surgery. Through the provision of a safety zone, the present devices and techniques offer reduced risk of spinal cord damage. In addition to improving nerve function, it is expected that decompression of the spinal canal in the manner described herein will result in improved blood flow to the neural elements by reducing the extrinsic pressure on the spinal vasculature. For these reasons, it is believed that spinal decompression performed according to the present invention will be preferable to decompression operations performed using currently known techniques.
- a mechanical device such as a balloon or mechanical shield can also be used to create a protective guard or barrier between the borders of the epidural space and the adjacent structures.
- a durable expandable device is attached to the outside of the percutaneous laminectomy device, preferably on the side opposite the cutting aperture. The cutting device is inserted into the ligamentum flavum with the expandable device deflated. With the aperture directed away from the spinal canal, the expandable device is gently expanded via mechanical means or inflated with air or another sterile fluid, such as saline solution, via a lumen that may be within or adjacent to the body of the device. This pushes the adjacent vital structures clear from the cutting aperture of the device and simultaneously presses the cutting aperture into the ligament.
- the grasping and cutting needles can then be deployed and operated as desired.
- the balloon does not interfere with tissue excision because it is located on the side opposite the cutting aperture.
- the cutting needle may be hemispherical (semi-tubular) in shape with either a straight cutting or a sawing/reciprocating blade or may be sized to be placed within the outer housing that separates the balloon from the cutting aperture.
- a self-expanding metal mesh is positioned percutaneously in the epidural space.
- a guide catheter is placed in the epidural space at the site of the intended surgical procedure.
- the mesh is preferably compressed within a guide catheter.
- the mesh expands in the epidural space, protecting and displacing the adjacent dural sheath.
- the mesh is pulled back into the guide sheath and the assembly removed.
- the mesh is deformable and compresses as it is pulled back into the guide catheter, in a manner similar to a self-expanding mesh stent.
- self-expanding stents There are many commercially available self-expanding stents approved and in use in other applications. However, using a self-expandable mesh as a device within the epidural space to protect and displace the thecal sac is novel.
- Embodiments of tissue excision tools, devices, and methods disclosed herein may take several forms and may be used in accordance with the MILD method described above, or used according to alternative procedures such as the ipsilateral approach minimally invasive ligament decompression procedure (ILAMP method) disclosed in U.S. application Ser. No. 11/382,349, which is hereby incorporated herein by reference in its entirety.
- ILAMP method minimally invasive ligament decompression procedure
- tissue excision devices In the descriptions of the tissue excision devices below, the distal portions of the devices are described in detail, distal referring to positions that are relatively closer to the region of interest (e.g., the thickened portion of the ligamentum flavum to be decompressed).
- An exemplary embodiment of a proximal end for the tissue excision devices, including an actuation means, is also described below.
- embodiments of tissue extraction devices described herein may be used with a variety of proximal ends and a variety of actuation means that are known and understood by those skilled in the art.
- FIGS. 31-33 illustrate the distal portion of an embodiment of a tissue excision device 200 in an open position.
- Tissue excision device 200 comprises an inner tubular 230 coaxially disposed within and slidingly engaging an outer sleeve 210 .
- Inner tubular 230 and sleeve 210 both share a central longitudinal axis 250 .
- Sleeve 210 has an inner radius R 1 (not shown), as measured from axis 250
- inner tubular 230 has an outer radius R 2 (not shown), as measured from axis 250 .
- outer radius R 2 is substantially the same or slightly less than inner radius R 1 such that the outer surface of inner tubular 230 slidingly engages the inner surface of sleeve 210 .
- Sleeve 210 and inner tubular 230 are permitted to move axially (i.e., along axis 250 ) relative to each other.
- Sleeve 210 and inner tubular 230 may be formed from any suitable hollow bodies including without limitation a hypotube, cannula, or catheter.
- sleeve 210 and inner tubular 230 shown in FIGS. 31-33 generally have a circular cross-section, in general sleeve 210 and inner tubular 230 may have any suitable shape and cross-section including without limitation circular, oval, or rectangular.
- Inner tubular 230 includes a central cavity or through bore 240 ( FIG. 32 ) that runs the length of inner tubular 230 .
- a cutting head 250 is disposed at the distal end of inner tubular 230 .
- cutting head 250 is formed integrally with inner tubular 230 such as by casting, molding, or machining.
- cutting head 250 may be manufactured separately from inner tubular 230 and then fixed to the distal end of inner tubular 230 by any suitable means, such as welding.
- Cutting head 250 preferably comprises a body 252 and three cutting arms 253 extending axially from body 252 .
- body 252 is integral with and essentially an extension of inner tubular 230 . Since each arm 253 extends axially from body 252 , each arm 253 may be described as including a fixed end 253 a integral with body 252 and a free end 253 b generally distal to body 252 .
- cutting head 250 may include any suitable number of cutting arms 253 including without limitation two, three, four, or more.
- Arms 253 are preferably integral with body 252 and inner tubular 230 .
- arms 253 may be formed by any suitable means including without limitation casting or molding, laser cutting, machining, or combinations thereof.
- arms 253 may alternatively be distinct components that are mechanically coupled to body 252 and inner tubular 230 generally at fixed end 253 a .
- arms 253 may be connected to inner tubular 230 by any suitable means, including without limitation welding, pins, or combinations thereof.
- bore 240 is contiguous with a tissue-receiving space 263 defined between arms 253 inside cutting head 250 .
- Tissue-receiving space 253 and bore 240 accommodate tissue excised by device 200 (e.g., excised pieces of ligamentum flavum).
- tissue-receiving space 263 inside cutting head 250 may include ridges, knurling or other textured surface features 264 thereon so as to further improve grasping and retention of tissue between arms 253 .
- Textured surface feature 264 may be formed by any suitable means including without limitation knurling, sand blasting, bead blasting, plasma etching, or combinations thereof.
- the inner surface of inner tubular 230 may be roughened to enhance the ability of inner bore 240 to enhance grasping and retention of excised portions of tissue.
- each arm 253 preferably terminates in a cutting or tissue-grasping member.
- two aims terminate in cutters 251 and a third arm terminates in a sharp anchoring tip 154 that extends beyond the distal ends of cutters 251 .
- Each cutting edge 251 preferably has a sharpened or beveled edge adapted to slice through tissue.
- anchoring tip 254 includes a tissue grasping member 257 that extends radially inward and helps grasp tissue and retain tissue within tissue-receiving space 263 .
- tissue grasping member 257 is a tooth.
- one or more tissue grasping members may comprise teeth, barbs, or the like. Tooth 257 preferably has sharpened edges to enhance cutting of tissue.
- arms 253 may be any desired length.
- Cutting head 250 is constructed so that arms 253 can be brought together so as to grasp tissue therebetween, termed herein as a “closed position”, and moved apart so as to release tissue and/or allow the entry of tissue between arms 253 , termed herein as an “open position”. As shown in FIGS. 31 and 32 , cutting head 250 is in an open position. Specifically when cutting head 250 is in an open position, cutting head 250 is extended from sleeve 210 and free ends 253 b of each arm 253 are radially spaced apart. Consequently, any tissue within tissue-receiving space 263 is not pinched or firmly grasped by arms 253 and tissue is allowed to enter tissue-receiving space 263 via the gap between free ends 253 b of arms 253 .
- each arm 253 preferably includes a frustoconical chamfer 255 on its outer surface.
- the surface of each frustoconical chamfer 255 extends radially beyond inner radius R 1 of sleeve 210 .
- cutting head 250 is extended from sleeve 210 and thus sleeve 210 does not engage frustoconical chamfer 255 .
- each frustoconical chamfer 255 is generally flee to extend radially beyond inner radius R 1 of sleeve 210 (i.e., sleeve 210 does engage chamfers 255 nor restrict arms 253 ).
- sleeve 210 when sleeve 210 is advanced toward cutting ends 253 b it engages the portions of frustoconical chamfer 255 that radially extend beyond inner radius R 1 of sleeve 210 , thereby tending to force arms 253 together.
- sleeve 210 continues to bear on chamfers 255 and arms 253 are brought closer together.
- Cutting head 250 achieves the closed position when arms 253 contact each other and/or when each radially outermost portions or ridge 260 of each frustoconical chamfer 255 is disposed within inner tubular 230 . At this point, cutting ends 253 b of each arm 253 are at their closest relative to each other. In some embodiments, cutting ends 253 b may engage adjacent cutting ends 253 b.
- sleeve 210 may be moved axially relative to cutting head 250 by any suitable manner including without limitation a threaded engagement with inner tubular 230 , a trigger mechanism, or combinations thereof.
- aims 253 are normally open.
- arms 253 are biased to the open position such that cutting head 250 will assume the open position when no forces are acting to push arms 153 together.
- compressive forces namely sleeve 210 acting on each frustoconical chamfer 255 .
- cutting head 253 will automatically assume the open position illustrated in FIG. 31 as sleeve 210 is retracted and cutting head 253 extends flom sleeve 210 .
- arms 253 may be biased closed and transitioned to an open position by providing an inner wedge between each arm 253 that urges the arms apart as it moves axially relative to arms 253 .
- FIGS. 34 and 35 schematically illustrate the excision of a portion of tissue 126 by device 200 .
- a portal or cannula (not shown) may be employed to provide percutaneous access to tissue 126 .
- tissue excision device 200 may be inserted into and advanced through such a portal or cannula to reach tissue 126 .
- tissue excision device 200 Regardless of the manner in which tissue excision device 200 reaches the tissue of interest (e.g., by portal or otherwise), prior to insertion into the tissue to be excised, device 200 is configured in the open position as shown in FIGS. 31 and 32 . With device 200 in the opened position, the distal portion of tissue excision device 200 is advanced into tissue 126 , as best shown in FIG. 34 .
- Tissue 126 may be any type of tissue to be excised and removed from a patient including without limitation, soft tissue, fat, muscle, or bone.
- cutting head 250 of device 200 is preferably inserted into the stenotic ligamentum flavum 26 , preferably posterior to a safety zone 40 , in order to safely cut and remove portions of the thickened ligamentum flavum 26 (see FIGS. 2 and 3 ), thereby reducing the stenosis.
- tissue 126 slide into and fill at least a portion of tissue-receiving space 263 between arms 253 within cutting head 250 . It is to be understood that the farther device 200 is advanced into tissue 126 , the greater the amount of tissue 126 that will occupy tissue-receiving space 263 . As tissue-receiving space 263 fills, some excess tissue within tissue-receiving space 263 may be pushed into bore 240 of inner tubular 230 . Arms 253 are preferably rigid such that cutting head 250 does not inadvertently transition to the closed position as device 200 is advanced through the tissue. In other words, arms 253 are preferably rigid so that the forces exerted on the outer surface of arms 253 by the surrounding tissue 126 as device 200 is advanced do not tend to move arms 253 towards each other.
- device 200 may be transitioned to the closed position by advancing sleeve 210 toward cutting ends 253 b and over cutting head 250 as previously described.
- the portions of tissue 126 within tissue-receiving space 263 and bore 240 are severed from the surrounding tissue 126 .
- the sharpened or beveled edges of cutters 251 and tooth 257 slice tissue extending axially from tissue-receiving space 263
- an annular cutting edge 211 of sleeve 210 slices tissue extending radially from tissue-receiving space 263 between arms 253 .
- Cutting edge 211 of sleeve 210 is preferably sharpened to enhance the cutting ability of sleeve 210 as it moves relative to cutting head 250 .
- the severed tissue 126 contained within tissue-receiving space 263 is grasped by arms 253 .
- arms 253 exert compressive forces on the tissue 126 within tissue-receiving space 263
- the textured surface features 264 on the inner surface of arms 253 grips the tissue 126 within tissue-receiving space 263
- tooth 257 grasps tissue 126 within tissue-receiving space 263 and restricts it from sliding axially out of cutting head 250 between cutting ends 253 b.
- device 200 maybe retracted from tissue 126 as best shown in FIG. 35 .
- the portion of tissue 126 contained within tissue-receiving space 263 and bore 240 is removed along with device 200 .
- device 200 including a portion of tissue 126 within tissue-receiving space 263 and bore 240 , has been completely removed from the patient, resected tissue within tissue-receiving space 263 and bore 240 is removed from device 200 so that device 200 may be reinserted into tissue 126 to continue to the cutting and removal of portions of tissue 126 .
- Pieces of tissue 126 captured within tissue-receiving space 263 and bore 240 may be removed by simply opening device 200 and pulling the pieces of tissue from tissue-receiving space 263 and bore 240 .
- Device 200 may be opened from the closed position by retracting sleeve 210 from cutting head 250 as previously described. As device 200 transitions to its opened position, arms 253 will separate, allowing the user to access tissue-receiving space 263 and inner bore 240 .
- a plunger or tissue ejector may be included with device 200 to physically eject the excised tissue 126 from tissue-receiving space 263 and inner bore 240 .
- a plunger (not shown) may be included within device 200 to push cut tissue in tissue-receiving space 263 and inner bore 240 axially out through the opening between cutting ends 253 b of arms 253 .
- the process of inserting device 200 into tissue 126 in the opened position, closing device 126 , retracting device 200 in the closed position, opening device 200 , emptying tissue-receiving space 263 and bore 240 , and reinserting device 200 may be repeated until the desired amount of tissue 126 has been excised and removed.
- this process may be repeated until the spinal canal is adequately decompressed.
- the cutting ends 253 b of each arm 253 of device 200 are preferably controlled to remain within ligamentum flavum 26 and not penetrate safety zone 40 . Nonetheless, safety zone 40 is preferably provided so that even an inadvertent penetration into epidural space 27 by device 200 will not result in damage to the dural sac 32 or nerves 34 .
- tissue excision device 200 may comprise any suitable material(s) including without limitation metals (e.g., stainless steel, titanium, etch), non-metals (e.g., polymer, composites, etc.) or combinations thereof.
- the components of tissue excision device 200 are preferably manufactured from a durable biocompatible material such as titanium or stainless steel, but may alternatively be polymeric.
- arms 253 each preferably comprise a relatively rigid material(s) capable of maintaining their shape and configuration when inserted into and advanced through tissue.
- arms 253 preferably comprises a resilient material having the ability to be repeatedly flexed between the open position and closed position without cracking or otherwise being damaged. Such a resilient material also enables each arm 253 to return to its original configuration once external forces (e.g., force applied by sleeve 210 ) are removed.
- tissue excision device 200 may be manufactured by any suitable methods. Examples of suitable methods include casting or molding, machining, laser cutting, EMD, or combinations thereof. In some embodiments, cutting edges or tips may be electro polished to for sharpening.
- the components of tissue excision device 200 may be assembled by any suitable method including without limitation welding, press fitting, or combinations thereof.
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- Pathology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Plant Substances (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Priority Applications (1)
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US11/461,036 US20070027464A1 (en) | 2005-07-29 | 2006-07-31 | Device for resecting spinal tissue |
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US70422405P | 2005-07-29 | 2005-07-29 | |
US74716606P | 2006-05-12 | 2006-05-12 | |
US11/461,036 US20070027464A1 (en) | 2005-07-29 | 2006-07-31 | Device for resecting spinal tissue |
Publications (1)
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US20070027464A1 true US20070027464A1 (en) | 2007-02-01 |
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US11/461,045 Active 2028-11-20 US8696671B2 (en) | 2005-07-29 | 2006-07-31 | Percutaneous tissue excision devices |
US14/019,135 Active US8894653B2 (en) | 2005-07-29 | 2013-09-05 | Percutaneous tissue excision devices and methods |
US14/032,770 Active US8882772B2 (en) | 2005-07-29 | 2013-09-20 | Percutaneous tissue excision devices and methods |
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US11/461,045 Active 2028-11-20 US8696671B2 (en) | 2005-07-29 | 2006-07-31 | Percutaneous tissue excision devices |
US14/019,135 Active US8894653B2 (en) | 2005-07-29 | 2013-09-05 | Percutaneous tissue excision devices and methods |
US14/032,770 Active US8882772B2 (en) | 2005-07-29 | 2013-09-20 | Percutaneous tissue excision devices and methods |
Country Status (8)
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US (4) | US20070027464A1 (fr) |
EP (3) | EP2335600B1 (fr) |
JP (1) | JP2009502365A (fr) |
AT (1) | ATE495701T1 (fr) |
CA (1) | CA2614721A1 (fr) |
DE (1) | DE602006019736D1 (fr) |
ES (1) | ES2637638T3 (fr) |
WO (2) | WO2007016686A2 (fr) |
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US20140024933A1 (en) | 2014-01-23 |
US20070055215A1 (en) | 2007-03-08 |
ES2637638T3 (es) | 2017-10-16 |
JP2009502365A (ja) | 2009-01-29 |
EP2335600A1 (fr) | 2011-06-22 |
EP2335600B1 (fr) | 2017-04-19 |
EP3228265A3 (fr) | 2018-05-23 |
EP1912575A4 (fr) | 2009-11-25 |
WO2007016683A3 (fr) | 2009-05-07 |
EP3228265A2 (fr) | 2017-10-11 |
EP1912575B1 (fr) | 2011-01-19 |
WO2007016686A2 (fr) | 2007-02-08 |
US8696671B2 (en) | 2014-04-15 |
US8882772B2 (en) | 2014-11-11 |
EP1912575A2 (fr) | 2008-04-23 |
DE602006019736D1 (de) | 2011-03-03 |
ATE495701T1 (de) | 2011-02-15 |
US20140005671A1 (en) | 2014-01-02 |
WO2007016683A2 (fr) | 2007-02-08 |
WO2007016686A3 (fr) | 2009-05-07 |
US8894653B2 (en) | 2014-11-25 |
CA2614721A1 (fr) | 2007-02-08 |
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