EP3410943B1 - Instrument de prélèvement de biopsie multifonction - Google Patents

Instrument de prélèvement de biopsie multifonction Download PDF

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Publication number
EP3410943B1
EP3410943B1 EP16889189.3A EP16889189A EP3410943B1 EP 3410943 B1 EP3410943 B1 EP 3410943B1 EP 16889189 A EP16889189 A EP 16889189A EP 3410943 B1 EP3410943 B1 EP 3410943B1
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EP
European Patent Office
Prior art keywords
biopsy
anesthetic
sample
instrument
site
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EP16889189.3A
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German (de)
English (en)
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EP3410943A4 (fr
EP3410943A1 (fr
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Aton M. HOLZER
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/10—Surgical instruments, devices or methods, e.g. tourniquets for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00353—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery one mechanical instrument performing multiple functions, e.g. cutting and grasping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A61B2017/06176—Sutures with protrusions, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0647—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0649—Coils or spirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3933—Liquid markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00—Local anaesthesia; Hypothermia

Definitions

  • This invention relates to instruments used in effecting or carrying out biopsies and in particular relates to instruments providing multiple biopsy functions.
  • a dermatological or skin biopsy procedure such as for determining skin cancer and the like, involves certain general procedures, which are often effected by different instruments.
  • a typical biopsy procedure entails the initial marking of the biopsy site with a visible marker. Thereafter, the marked site is injected with a local anesthetic, typically lidocaine.
  • a skin removal device for the typical removal of a skin sample of between 3-5mm is used for obtaining the sample for biopsy (most commonly 4mm).
  • skin removal devices are commonly of two types, a skin scraper for removal of a shallow skin sample, and a skin punch, which cores a skin sample of greater depth.
  • Use of the skin punch requires further measures for wound closure such as suturing or cauterizing of the punch wound. Because of the shallower depth of skin removal by the skin scraper, wound closure with a suture may or may not be required, depending on the nature of the biopsy wound.
  • punch biopsy of the skin is a procedure by which dermatologists obtain tissue for histopathologic evaluation.
  • the procedure as currently done requires several components.
  • the dermatologist who wishes to perform the punch biopsy must incise the skin, and then drop the obtained tissue sample into an open specimen bottle.
  • the dermatologist must generally have an assistant on hand to assist.
  • It is a further object is to provide a biopsy system that facilitates injection of anesthetic, removal and ejection of obtained biopsy specimens and wound closure by means of one disposable device, resolving many, if not all, of the inefficiencies and pitfalls of common prior art procedures.
  • the scope of the invention is defined by independent claim 1. Preferred embodiments are defined in the dependent claims.
  • An instrument for use in a dermatological biopsy sampling procedure as disclosed herein comprises a hand-held device comprising:
  • the instrument comprises a housing for the anesthetic dispensing member and biopsy sample taking member with the housing having an aperture therein adapted to be placed into contact directly against the biopsy site.
  • the instrument comprises an extension and retraction mechanism configured to enable the anesthetic dispensing member and biopsy sample taking member to be alternately brought into proximate position relative to the selected biopsy site through the aperture. This enable the alternate and sequential providing of an anesthetic to the selected biopsy site and to take a biopsy sample from the anesthesized biopsy site, respectively, without necessity for removal of the instrument from contact with the biopsy site. This facilitates single user operation and accuracy biopsy site sampling.
  • a further embodiment herein comprises a single use multi-function biopsy instrument in a pen-like configuration comprising an anesthetic dispensing member with a dispensing activating element and a skin biopsy sampling member with a sample taking control element.
  • Each of the anesthetic dispensing member and skin biopsy sampling member comprises an advancing and retracting mechanism configured for the alternating positioning and operative functioning of the anesthetic dispensing member and the skin biopsy sampling member at a single skin site without the necessity of moving the instrument out of a single position placement, for effecting the skin biopsy sampling.
  • the single site placement of the anesthetic dispensing and the biopsy sampling ensures greater accuracy, expedited handling and reduced possibility of patient pain.
  • the instrument may also integrally contain a site marking element or marker and an integral suturing member, with the latter, in one embodiment, being provided with its own advancing and retracting mechanism and operational manipulating suturing element.
  • the advancing and retracting mechanism of the integral suturing member, when part of the device, is further alternated with the positioning of the other functional members used in the biopsy sampling procedure.
  • the integral suturing element positions and operationally rotationally sets a surgical suture with a barbed absorbable staple configuration.
  • the marking element is contained within a cap for the biopsy pen instrument and the anesthetic dispensing member, skin biopsy sampling member and the integral suturing member, when present, are longitudinally positioned and arranged within a cylindrical barrel having a tapered open end, similar to that of a pen, through which the respective members are extended to effect the respective functions of anesthetic delivery, skin biopsy sampling and optional suturing.
  • Suturing if required, may be effected by a separate suturing instrument and its inclusion in the instrument herein is desirable though not necessary.
  • the device described herein allows the hurried practitioner to easily perform a punch or scraping biopsy procedure without the need for assistants. It also ensures the easy removal of the specimen from the coring or scraping blade and removes the possibility of a crushed artifact. Additionally, with the integral suturing element, placement of the absorbable suture or staple obviates the need for a return visit for suture removal.
  • a dermatological biopsy sample is obtained from a patient's skin with the steps of:
  • a multifunction pen type device for skin biopsy comprises three cartridges, which are individually selectively advanceable to the tip of the device and are substantially completely retractable into the body of the device.
  • a pressure element is biased under spring action or other bias device to bring the respectively chosen function cartridge into the use position, and then returned into the rest or storage position by means of intermediate members.
  • a plurality of pins which carry the different function cartridges are displaceable in the lower part of a housing.
  • swingable push rods actuable by means of pressure elements, which co-act with the respective underlying cartridge carrying pins in, for example, a diagonal or horizontal position.
  • a displaceable pressure pin may be used for choosing, advancing and retracting the function cartridge, which is under the influence of a conical spring or other bias device arranged in a bushing threaded into the casing in operating position and in the rest position, with a control pendulum mounted on the spring longitudinally limited thereby and rotatable therein.
  • a guide part is positioned at the forward end of the casing with a cartridge-bearing pin longitudinally displaceable in the longitudinal bores of the guide part under the influence of coil springs and provided with joints at its rear end and a locking guide ring positioned at the guide part.
  • Other cartridge selection mechanisms may optionally be used.
  • each cartridge is equipped with a depressible tab that completes its function.
  • the three cartridges include a syringe containing a local anesthetic, which can be injected by depressing its tab; a coring blade for punch biopsy, equipped with a curving blade at one lateral aspect that can be lowered via the depressible tab to incise the base of the specimen and enclose it within the coring blade, and, when subsequently raised to a height above the coring blade, enters the coring blade from above so that it can be lowered to eject the collected specimen; and a tube containing an S-shaped barbed absorbable surgical hook, or a three- (or more) armed surgical hook, or an absorbable suture or barbed helical suture that, when lowered into the wound, can be twisted and detached to achieve wound closure.
  • Another embodiment may have, in place of the cartridge with coring and curving blades, a scoop-like blade and barrel to perform a shave biopsy, and in place of the cartridge containing the absorbable hook, a cartridge containing chemical cauterant, or cyanoacrylate glue.
  • Another embodiment could incorporate a fourth cartridge with a tattoo needle and either permanent or temporary UV-fluorescent tattoo ink to provide a mark of the biopsy site for the purpose of future identification of the biopsy site of a skin cancer.
  • a gentian violet surgical marking pen is incorporated into the push button at the base of the device.
  • the user uncaps the surgical marker and uses it to draw a circle around the desired punch location.
  • the push button is depressed, advancing the syringe of anesthetic to the tip of the device. Depression of the depressible tab of the syringe injects anesthetic into the desired site.
  • the push button when depressed again, advances the coring blade to the tip of the device. The practitioner rotates the coring tip into the skin to create the incision, and advances the tip to its hub. Depression of the depressible tab of the coring blade cylinder to its lowermost point advances the curved blade to below the space of the coring blade, and the user rotates the device to incise the entire base of the specimen.
  • the device is then lifted, pulling the specimen out of the skin.
  • the user positions the device above a specimen bottle, raise the depressible tab to its highest point to position the curved blade above the coring blade, and depresses the depressible tab, pushing the flat end of the curved blade into the coring blade, to serve as a piston to eject the specimen into the bottle.
  • the push button is then depressed for the third time, advancing the tube containing the S-shaped surgical hook.
  • the tube is inserted into the wound, and the tab depressed to lower the surgical hook into the base of the wound.
  • the user twists the device to close the wound, and then lifts the device off of the wound to detach the S-shaped hook, completing the biopsy and closure.
  • separate activation devices and/or push buttons may be provided for each cartridge and/or function.
  • the device since the device is for single use, the specimen is retained in a receptacle integrated with the coring or scraping element and the receptacle is removed in toto for retrieval of the specimen in a fully intact state.
  • Figures 1-3 depict views of the biopsy pen 10, with a surgical marker 11, contained within cap 12 and in exploded and cross sectioned views respectively.
  • the operational cartridges 13, 14 and 15; of anesthetic delivery syringe 13, biopsy sampling (coring and scraping) element 14 and suturing element 15, are longitudinally positioned within pen barrel 10a, with their operational elements (of anesthetic dispensing needle 13a; coring blade 14a, curved scraping blade 14b; and surgical suture holder 15a), being directly adjacent pen aperture tip 10b, for alternative operational extension therefrom.
  • the specific instrument being used is provided with either the coring or scraping blade for more specific operation control, though both biopsy removal blades may be selectively included with appropriate mechanism for selection such as with separate cartridge elements.
  • the pen barrel 10a is further provided with cartridge selection control device 16 for selection and extension/retraction control of the cartridge appropriate for a desired function.
  • Control tabs 13', 14' and 15' integrated with cartridges 13, 14 and 15 respectively (as shown in Figures 4 , 5 , and 6 respectively), serve to effect the appropriate function of the desired cartridges (injection, scraping or coring, and suturing).
  • Internal springs 23, 24 and 25 with pins 33, 34, and 35 for cartridges 13, 14 and 15 respectively provide requisite position and operation tension forces for the extension/retraction of the selected respective cartridges.
  • the operation tips 13a, 14a and 14b and 15a are held in an offset position relative to the aperture tip 10b until extended for use and with such extension are moved into alignment with the aperture tip 10b and therethrough for effecting the designated function.
  • Figure 4 depicts the anesthetic needle dispenser cartridge 13, apart from the pen structure, with control tab 13', plunger shaft 33, plunger tip 33a, anesthetic ampoule 34 with contained anesthetic 34a, needle hub 13b and needle 13a.
  • FIGs 5a and 5b show the biopsy sample obtaining structure 14, with spring 32, plunger barrel 34 and plunger tip 34a and control tab 14'.
  • the biopsy tip 14a in Figure 5a comprises a curved blade 14a' and coring blade 14a".
  • the biopsy tip 14b in Figure 5b shows the alternative shave biopsy mechanism with sharp scoop blade 14b' and blunt edge receptacle 14b".
  • the optional suturing cartridge 15 is shown in Figure 6 with control tab 15' driving shaft 35 longitudinally contained and movable within semicircular barrel 36 to operate blunt hollow tip 15a engaged with one of barbed absorbable sutures shown in Figure 7a (s-shaped staple 45), Figure 7b (3-pronged suture 46) and Figure 7c (barbed helical suture 47) via metal shaft connector 40 of hollow tip 15a for rotational suturing deployment to close a biopsy wound.
  • tip 15a is shaped with a small ampoule configuration 50 containing a medical grade cyanoacrylate glue or chemical cauterant which is dispensed on the biopsy wound site through dispensing tip 51 to effect a biopsy wound closure without sutures.
  • the cap 12 is initially removed at A and the marker 11 is used to mark (with a small diameter circle) the biopsy site 100 at B. Thereafter, with the cap 12 having been replaced the cap is pressed at C to depress an internally contained pressure member, which initially causes the needle 13a of the anesthetic dispensing cartridge 13 to operationally extend out of tip opening 10b at D and the needle 13a is positioned into the marked biopsy site and tab 13' is depressed to inject anesthetic into the biopsy site 100.
  • the cap 12 is then pressed again at E to depress the pressure member.
  • This causes the biopsy-sampling cartridge 14 to move into position at F and in turn causes the tip 14a (with either coring tip 14a' or shaving tip 14a") to extend into engagement with the biopsy site 100.
  • the biopsy instrument 10 is then rotated at G for coring or shaving and then the tab 14' is depressed to effect the coring or shaving incision under or on the skin surface at the biopsy site 100.
  • Raising of tab 14' at H lifts the biopsy sample from the biopsy site with the sample being retained within the coring blade 14a" or blunt edge receptacle 14b" with the biopsy instrument 10 being lifted from the biopsy site 100. Depression of tab 14' thereafter, as shown, ejects the specimen for collection within receptacle 101.
  • the biopsy instrument 10 is repositioned on the biopsy wound the cap 12 is again pressed to depress the pressure member at I to bring the suturing cartridge 15 into position and operative extension with suturing tip 15a.
  • Tab 15' is depressed to implant the absorbable suturing staple (45, 46, or 47) or to dispense the cyanoacrylate glue or cauterant.
  • the biopsy instrument 10 is then rotated to close the wound with any of the surgical staples, glue or cauterant and the biopsy instrument is lifter to detach it from the staple, glue or cauterant and the biopsy instrument is then discarded.
  • ejection of the biopsy sample need not be made prior to the suturing step, with the biopsy instrument remaining in position against the biopsy site and wound 100 until after the suturing or wound closure has been effected and the biopsy sample being harvested with removal of the biopsy sample cartridge 14 and removal of the contained sample therefrom.

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Claims (14)

  1. Instrument à main de prélèvement de biopsie (10) comprenant :
    un élément (13, 13a) conçu pour administrer un anesthésique à un site de biopsie sélectionné,
    un élément (14, 14a) conçu pour prélever un échantillon de biopsie du site de biopsie, et
    un boîtier (10a) pour l'élément d'administration d'anesthésique (13, 13a) et l'élément de prélèvement d'échantillon de biopsie (14, 14a), le boîtier (10a) comportant une ouverture (10b),
    le boîtier (10a) comprend en outre un mécanisme d'extension et de rétraction (13', 14') conçu pour permettre à l'élément d'administration d'anesthésique (13, 13a) et à l'élément de prélèvement d'échantillon de biopsie (14, 14a) d'être tenus dans une position décalée par rapport à l'ouverture (10b), caractérisé en ce que l'ouverture (10b) est adaptée pour être placée en contact directement contre un site de biopsie sur la peau d'un utilisateur, et en ce que le mécanisme d'extension et de rétraction (13', 14') est en outre conçu pour permettre à l'élément d'administration d'anesthésique (13, 13a) et à l'élément de prélèvement d'échantillon de biopsie (14, 14a) d'être amenés tour à tour en alignement avec l'ouverture (10b) pour s'étendre au travers, afin de fournir un anesthésique au site de biopsie sélectionné et de prélever un échantillon de biopsie du site de biopsie anesthésié, sans qu'il soit nécessaire de retirer l'instrument (10) du contact avec le site de biopsie.
  2. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel le boîtier (10a) comprend en outre :
    un élément de fermeture de plaie (15) conçu pour tenir, appliquer et commander un élément (15a) destiné à la fermeture d'une plaie causée par le prélèvement de l'échantillon de biopsie,
    le mécanisme d'extension et de rétraction (13', 14', 15') étant en outre conçu pour permettre à l'élément de fermeture de plaie (15) d'être amené, à la suite de l'élément de prélèvement d'échantillon de biopsie (14, 14a), en alignement avec l'ouverture (10b) pour s'étendre au travers.
  3. Instrument de prélèvement de biopsie (10) selon la revendication 2, dans lequel l'élément de fermeture (15a) comprend une agrafe de suture résorbable (45, 46, 47), une colle de qualité médicale ou un agent cautérisant.
  4. Instrument de prélèvement de biopsie (10) selon la revendication 3, dans lequel l'élément de fermeture (15a) comprend une agrafe de suture résorbable à pointes ayant au moins une forme en s (45), une forme hélicoïdale (47) ou une forme à trois dents (46), d'une largeur avant extension à travers ladite ouverture (10b) inférieure à un diamètre de l'ouverture (10b), de sorte que l'élément de fermeture de plaie (15) maintient l'agrafe de suture (45, 46, 47) et est adapté pour la transporter à travers l'ouverture (10b) pour la fermeture de la plaie de biopsie.
  5. Instrument de prélèvement de biopsie (10) selon la revendication 3, dans lequel l'élément de fermeture de plaie (15) comprend un réceptacle ouvert (50) contenant un agent d'obturation de qualité médicale comprenant une colle ou un agent cautérisant, où l'élément de fermeture de plaie (15) est conçu pour administrer ledit agent d'obturation sur la plaie de biopsie afin de la fermer.
  6. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel l'élément d'administration d'anesthésique (13) comprend une seringue (34) contenant un anesthésique, l'élément d'administration d'anesthésique (13) étant conçu pour insérer la seringue (34) dans le site de biopsie et pour y administrer l'anesthésique.
  7. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel l'élément de prélèvement d'échantillon de biopsie (14) comprend :
    un élément de poinçon de carottage de biopsie (14a) conçu pour perforer le site de biopsie afin de séparer un échantillon de cœur du site de biopsie, et
    un élément de retenue d'échantillon (14a') d'où l'échantillon de cœur peut être récupéré.
  8. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel l'élément de prélèvement d'échantillon de biopsie (14) comprend :
    un élément de raclage de biopsie (14b') conçu pour séparer un échantillon de peau du site de biopsie, et
    un élément de retenue d'échantillon (14b") dans lequel l'échantillon de peau est déplacé et d'où l'échantillon de peau peut être récupéré.
  9. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel le boîtier (10a) comprend en outre un élément de marquage (11) conçu pour marquer le site de biopsie en vue de la position de l'application d'anesthésique sur le site de biopsie et pour le prélèvement de biopsie.
  10. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel le boîtier (10a) a une configuration allongée de type stylo à main avec l'ouverture (10b) située au niveau d'une extrémité terminale de la configuration allongée de type stylo.
  11. Instrument de prélèvement de biopsie (10) selon la revendication 10, dans lequel le boîtier (10a) comprend en outre des commandes externes pour les doigts et les mains (13', 14') pour actionner sélectivement le mécanisme d'extension et de rétraction et pour effectuer l'administration d'anesthésique et le prélèvement de biopsie.
  12. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel le mécanisme d'extension et de rétraction (13', 14', 15') comprend des pattes pouvant être enfoncées.
  13. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel ledit élément d'administration d'anesthésique (13) comprend une seringue (13a) munie d'une aiguille de distribution (30a) à l'intérieur du boîtier conçue pour administrer l'anesthésique sur le site de biopsie cutanée sélectionné.
  14. Instrument de prélèvement de biopsie (10) selon la revendication 1, dans lequel ledit boîtier (10a) comprend en outre un élément ayant une aiguille de tatouage conçue pour distribuer une encre de tatouage fluorescente afin de marquer le site de biopsie en vue de son identification future.
EP16889189.3A 2016-02-02 2016-02-02 Instrument de prélèvement de biopsie multifonction Active EP3410943B1 (fr)

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US20220211356A1 (en) 2019-02-11 2022-07-07 Singapore Health Services Pte Ltd Device for skin biopsy

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CA2199864C (fr) * 1994-09-16 2006-06-20 Seth A. Foerster Procedes et dispositifs pour delimiter et marquer des tissus corporels
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
US6280399B1 (en) * 1998-10-06 2001-08-28 Allegiance Corporation Substance delivery device for use with a procedure performing instrument
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JP2006087474A (ja) * 2004-09-21 2006-04-06 Olympus Corp 処置具システム及び内視鏡処置システム
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Publication number Priority date Publication date Assignee Title
WO2023052742A1 (fr) * 2021-09-29 2023-04-06 Neuro-Bio Ltd Biomarqueur de la peau

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Publication number Publication date
CA3013176C (fr) 2023-09-26
EP3410943A4 (fr) 2019-09-18
JP2019508197A (ja) 2019-03-28
WO2017134649A1 (fr) 2017-08-10
EP3410943A1 (fr) 2018-12-12
JP6745359B2 (ja) 2020-08-26
CA3013176A1 (fr) 2017-08-10

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