US20060280646A1 - Vacuum sterilization process and devices - Google Patents

Vacuum sterilization process and devices Download PDF

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US20060280646A1
US20060280646A1 US10/556,621 US55662105A US2006280646A1 US 20060280646 A1 US20060280646 A1 US 20060280646A1 US 55662105 A US55662105 A US 55662105A US 2006280646 A1 US2006280646 A1 US 2006280646A1
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chamber
vacuum
plasma
vapour
sterilization
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Tadashi Shiosawa
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CISA SpA
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Assigned to CISA S.R.L. reassignment CISA S.R.L. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SHIOSAWA, TADASHI
Publication of US20060280646A1 publication Critical patent/US20060280646A1/en
Priority to US12/537,546 priority Critical patent/US8663555B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/24—Apparatus using programmed or automatic operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/208—Hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/122—Chambers for sterilisation

Definitions

  • the present invention relates to a sterilization process, operational devices and respective methods applied for the sterilization of various different items of apparatus and products, using vacuum techniques, the application of sterilizing gas and plasma. More particularly, this invention makes use of gas from a solution of peracetic acid or hydrogen peroxide evaporated under vacuum, with the partial separation of water from the solution for sterilization, as well as the use of plasma from residual atmospheric air for the elimination of residues, with temperature monitoring and control.
  • the Freshfill System which uses the sanitizing agent in the form of a spray. Jets of sterile hot air activate the peroxide and eliminate the residue;
  • the Serc System uses a mixture of chlorinated water, hydrogen peroxide, and peracetic acid. The material remains in contact with the sanitizing agent for about 90 seconds. This is followed by rinsing with sterile water;
  • the ethylene oxide sterilization system (ETO) largely used for sterilizing heat-sensitive materials with a high degree of penetrability of the materials, which requires heating up to 58° C. and can also use Freon gas in the process.
  • the system If applied in the form of vapour or spray, the system requires air which is filtered, hot, and sterile, in order to activate and eliminate the residues. These systems incur high energy consumption, as a function of the use of heater devices.
  • the process with ethylene oxide requires long periods of sterilization, as well as aeration, since this substance is highly toxic.
  • Sterilization with plasma is one of the most recent techniques for the sterilization of surgical instruments and represents a great number of advantages over the procedures referred to heretofore.
  • the plasma state of the material is obtained by means of electrical discharge in a high-voltage field, DC, AC, or pulsed, in gases at low pressure.
  • the action of this field on the gas or vapour molecules results in the provision of sufficient energy to the charged particles (electrons and ions), and these begin to produce pairs of electron-ions as a result of collision with the neutral gas molecules.
  • the formation takes place of ions, accelerated electrons, neutral types, free radicals, and excited atoms and molecules, as well as the emission of ultraviolet radiation. If the application of the field is stopped, the activated types recombine, forming other types or returning to their basic state.
  • STERRAD® One commercial application of sterilization by plasma is described by the STERRAD® system.
  • the materials are placed in a chamber in which a vacuum is then created.
  • a solution of hydrogen peroxide is injected and vaporised inside the chamber containing the items which are to be sterilized.
  • the pressure in the chamber containing this vapour is reduced and a plasma is initiated, with radio frequency energy being provided in order to exterminate micro-organisms and remove residues.
  • the process is completed by disconnecting the RF energy and admitting filtered gas (HEPA) into the chamber.
  • HEPA filtered gas
  • Patent PI 9708498-0 (U.S. Pat. No. 628,965), entitled “Method of Sterilization in Environments with Restricted Diffusion” makes use of hydrogen peroxide vapour as the former material and electrical discharges by radio frequency to generate plasma.
  • a source of peroxide which may be static flooding, spraying, condensation of hydrogen peroxide vapour or peracetic acid vapour, before exposure to a vacuum or in a vacuum followed by plasma.
  • the difficulty with penetration of the hydrogen peroxide in the environment with restricted diffusion is due to the presence of water vapour which, because it reaches the area concerned first, has a higher vapour pressure, which turns it into a barrier to penetration by the hydrogen peroxide vapour.
  • Patent PI 9504382-9 A (U.S. Pat. No. 320,932), with the title: “Method of Sterilization under Vacuum, Method of Evacuation of a Condensed Material, and Method of Drying”, describes a method of drying under vacuum with the liquefaction to plasma of residual gas and sterilization by the injection of sterilizing gas and a radio frequency source applied for the generation of plasma with the sterilizing gas. After a period allowed for diffusion in the sterilization process, the sterilizing gas, which is highly oxidant, is evacuated from the chamber by a vacuum pump in order to obtain lower pressure levels and to generate a plasma from this vapour, excited by an RF source.
  • the electrical discharge with radio frequency (RF) for the excitation of the plasma requires impedance couplers in order to obtain better utilization of the power supplied to the plasma.
  • RF radio frequency
  • An object of the present invention is to provide a sterilization process which, in association with the operational devices and respective methods, differs from the commercial processes and patents referred to heretofore, and presents numerous advantages, being:
  • the initial plasma formed with the residual gas from filtered atmospheric air by means of the present process, is applied in order to establish an adequate temperature and to enhance the active principle of the sterilizing gas which is to be injected;
  • the excitation of the plasma used is effected by means of a pulsed DC power source instead of the radio frequency (RF) source referred to in the documents referred to heretofore.
  • the pulsed DC signal is especially selected so as to avoid excessive heating at the plasma generating electrode, and has the advantage over RF of not requiring impedance couplers. Consequently, the excitation of the plasma is simpler and is less dependent on the type of charge (metal, glass ceramics, or plastic) and the design format of the electrode. Another advantage is the lower cost of manufacture.
  • the plasma applied in the process is induced by means of a gaseous atmosphere obtained from successive dilutions of the sterilizing gas with filtered atmospheric air, the aim of which is solely the elimination and removal of the residues of the sterilizing gas from the materials at the end of the sterilization process, contrary to the forming of plasma from the vapour of the residual sterilizing gas, the aim of which is the sterilization and removal of the residues from the previous systems.
  • One advantage of plasma formed with gas from residual filtered atmospheric air over plasma from the vapour of the sterilizing gas from the process referred to heretofore lies in the preservation of the vacuum system by doing away with the passage of the concentrated sterilizing gas through this system.
  • biological materials such as grains, seeds, and other foodstuffs may have hygroscopic characteristics, and accordingly an exchange of water is created between them and the air, principally in the form of vapour.
  • micro-climates are established on the surfaces of the products, the states of which are influenced principally by the moisture content of the products.
  • the quantity of water available is expressed by the aqueous activity factor (aa), which varies from 0 to 1.
  • aa aqueous activity factor
  • This factor is defined as being the ratio between the current pressure value of the water vapour in the micro-climate and the pressure of the vapour on the surface of a piece of pure water, which represents the vapour pressure under conditions of saturated air.
  • the moisture content defines the vapour pressure values and the factor a a on the surface of the product.
  • the intergranular space an environment is established of which the state and conditions are influenced principally by the moisture content of the grain mass, which may favour the development of micro-organisms or not, something which depends on the factor a a .
  • Fungi also referred to as moulds or mildews
  • moulds or mildews are multi-cellular filament micro-organisms which, if they infest grains or other foods, may produce toxic substances, such as micro-toxins. In the case of grains, infestation may occur during cultivation or in the post-harvest period.
  • Bacteria develop in the products, which have an aqueous activity greater than 0.90, although for fungi the values vary from 0.65 to 0.90, due to which the grains may have a moisture content from 14 to 22%. Accordingly, a drying process is used in the preservation of grains. This reduces the moisture content of the products to levels at which the aqueous activity does not favour the proliferation of fungi.
  • the relative humidity of the intergranular air corresponds to 100 times the value of aqueous activity.
  • the relative humidity of the air is referred to as relative humidity of equilibrium and the humidity of the grains as humidity of equilibrium.
  • the present invention allows for this sanitization to be carried out with in-house equipment, without the need for the use of plasma, and without the need for the articles which are to be sterilized (or sanitized) to be subjected to a vacuum in the interior of the chamber, they being duly exposed, when wrapped in non-woven fabric packaging and for a predetermined period of time, to the vapour from the mixture obtained by evaporation with heating of the solution of peracetic acid, hydrogen peroxide, and acetic acid, allowing for the diffusion of this vapour in association with a renewed exposure to subsequent vacuum to eliminate the micro-organisms present in the articles and without the need for exposure to plasma.
  • FIG. 1 Schott al.
  • FIG. 2 Separator device for separating water from the solution of the mixture of peracetic acid, hydrogen peroxide, and acetic acid, and an injector for the vapour of the remaining mixture;
  • FIG. 3 Pressure graph as a function of the time of the sterilization operational cycle
  • FIG. 4 Preferred embodiment of the configuration of the electrode stand developed for the homogenous distribution of plasma in the interior of the chamber in such a way as to keep the plasma close to the materials which are to be sterilized, where FIG. 4A refers to a photo of the electrode stand and FIG. 4B represents a schematic diagram of a side view of the electrode stand;
  • FIG. 5 Schott al.
  • FIGS. 6 and 7 show photographs of the sterilization equipment in which are applied the innovative process, the devices, and the operational methods.
  • the present invention relates to a vacuum sterilization process with the application of steam of a mixture of peracetic acid with hydrogen peroxide and residual gas plasma from atmospheric air, excited by pulsed electrical discharge; to operational devices and methods used in the sterilization process, the process and devices being exemplified and illustrated in particular in a diagrammatical manner in FIG.
  • a vacuum system consisting of at least one mechanical vacuum pump ( 4 ) and at least one ring-type liquid vacuum pump ( 5 ), connected in parallel and linked to the said chamber by means of valves ( 6 ) and ( 7 ).
  • the process in question provides for a device ( 8 ) with an injector system for sterilizing gas, in which takes place the evaporation and separation of water from the solution of the mixture of peracetic acid or peroxide solution, and a system for the admission of atmospheric air, consisting of a HEPA® filter and dehumidifier ( 11 ), connected to the chamber ( 1 ) by valves ( 9 ) and ( 10 ) and to the dehumidifier ( 11 ) by a valve ( 11 a ).
  • the chamber ( 1 ) is provided with a stand ( 12 ), consisting of level surfaces which, as well as serving as support for the articles (M) which are to be sterilized, also include the electrodes (E) at which the plasma for the sterilization is formed.
  • Each of the electrodes (E) on the stand ( 12 ) is electrically connected to a power source which generates a pulsed DC signal ( 13 ), responsible for the supply of the energy for the excitation of the plasma.
  • the process is automatic, being controlled by a programmable logic controller ( 14 ), which manages the operational sequence of sterilization as well as monitoring and controlling the procedures and possible variables in relation to the materials used in the sterilization and in relation to the articles (M) which are to be sterilized, so optimising the operational time of the process.
  • a programmable logic controller 14
  • the process is automatic, being controlled by a programmable logic controller ( 14 ), which manages the operational sequence of sterilization as well as monitoring and controlling the procedures and possible variables in relation to the materials used in the sterilization and in relation to the articles (M) which are to be sterilized, so optimising the operational time of the process.
  • each electrode which is located on the stand ( 12 ) has been developed in such a way as to cause a homogenous distribution of the plasma in the interior of the chamber, as well as in order to keep the plasma close to the articles (M) which are to be sterilized.
  • each electrode (E) on the stand ( 12 ) comprises two parallel shafts ( 12 a ) with segments ( 12 b ) in between, which can be configured as squares, spirals, or any other suitable shape to accommodate the electrode proper, and allowing that, with regard to the materials mounted on the stand ( 12 ), the plasma is generated in the area closely surround the electrode (E).
  • the device ( 8 ) of FIG. 1 is responsible for the application of the vapour from the solution of the liquid mixture of peracetic acid and hydrogen peroxide (ML) evaporated in a vacuum with heating and by the separation of the water from the solution, said device consisting for preference of a stainless steel needle ( 15 ) fixed in a base ( 16 ) which comprises in its interior an expansion chamber ( 17 ) to which said needle is connected, said expansion chamber being provided with a means of communication with the valves ( 9 ) and ( 10 ).
  • Said device ( 8 ), more particularly in the area of the needle ( 15 ), is supplemented by an ampoule ( 18 ) made of opaque material, of amber glass type or coated against luminosity, made of aluminium or other material, this ampoule ( 18 ) presenting one single passage which is blocked off by an inset blocking element ( 19 ) and which is connected to the base ( 16 ) by means of a guide piece ( 20 ).
  • the needle ( 15 ) perforates the blocking element ( 19 ), allowing for a connection between the product present in the ampoule ( 18 ) and the expansion chamber ( 17 ), which in turn is connected to the sterilization chamber ( 1 ) via the valve ( 9 ), at the same as connecting to the liquid ring pump ( 5 ) via the valve ( 10 ).
  • the needle ( 15 ) is made of stainless steel; the ampoule ( 18 ) is made of amber glass or coated against luminosity or of aluminium or another equivalent material.
  • the operational method put into effect by the device ( 8 ) consists primarily of the water from the solution (ML) present in the ampoule ( 18 ) being evaporated in a vacuum with heating of the guide piece ( 20 ), this evaporation being conducted to the chamber ( 17 ) via the needle ( 15 ) and, consequently, to the liquid ring pump ( 5 ).
  • the remainder of the solution (ML) present in the ampoule ( 18 ) is also evaporated under vacuum with heating, and the sterilizing vapour is conducted to the chamber ( 1 ) via the valve ( 9 ), where it expands and diffuses onto the articles (M) which are to be sterilized.
  • the operational method of the process in question comprises the following steps:
  • the present invention by means of this innovative process, allows for sterilization to be carried out at the level of sanitization in the equipment itself, without the need for the use of plasma, in which case the articles (M) which are to be sterilized (or sanitised) are arranged in stands ( 12 ), duly enclosed in packaging made of non-woven material.
  • these items are subjected to vacuum and to the vapour from the mixture obtained by evaporation with heating of the solution of peracetic acid, hydrogen peroxide, and acetic acid, allowing for the diffusion of this vapour in association with another exposure to the subsequent vacuum, so eliminating the micro-organisms present in the articles without the need for exposure to plasma.
  • the operational method for the sanitization/sterilization of articles without the need for plasma comprises the following steps:
  • Plasma-Based Sterilization Process Testing for Application in Medical Instruments.
  • the evaluation of the process efficiency was done testing the microbial reduction of the Bacillus Subtilis var. niger ( globigii ), Bacillus Stearothermophilus, E. coli and Pseudomonas Florence Microorganisms.
  • Bacillus Subtilis (tested in an inox and plastic substrate)
  • Bacillus Stearothermophilus (tested in an inox and plastic substrate)
  • the testing war performed putting the strips with the microorganisms in the geometric center of the three stacks in each bag, arranged in three shelves two by two, as shown in the illustration. After the processing, the treated strips and the control samples with B. subtilis were put in a Triptone Soya Agar (TSA) medium and incubated under 35° C. for 48 hours to evaluate the surviving colonies, in any.
  • TSA Triptone Soya Agar
  • Every item was double wrapped in envelopes of non-waven trilaminate fabric and arranged inside the sterilization chamber.
  • the efficiency test were performed with the same standard kit of spores of B. subtilis var niger ( globigii ) ATCC 9372, approximate population of 1.0 ⁇ 10 6 UFC/strip, according to a certification issued by the Cefar laboratories, with the same kit used in the ETO sterilization process and thermal processes.
  • the testing was performed putting the strips with the microorganisms in the same bag containing the articles to be sterilized, as shown in the figure below. After the processing the treated strips and the control samples with B. subtilis were put in a Triptone Soya Agar (TSA) medium and incubated under 35° C. for 48 hours to evaluate the surviving colonies, if any.
  • TSA Triptone Soya Agar
  • thermo-sensitive material-based latex, plastics, silicone, lenses
  • Inox steel items are easily sterilized.
  • the hardest items for sterilization are tubing, and the longer and narrower the tubing the harder is to get a proper sterilization level.
  • the sterilization process is able to process at the desired levels at open ended tubing with up to 5 mm in diameter and 3 m in length.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
US10/556,621 2004-01-16 2005-01-14 Vacuum sterilization process and devices Abandoned US20060280646A1 (en)

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US12/537,546 US8663555B2 (en) 2004-01-16 2009-08-07 Vacuum sterilization process and devices

Applications Claiming Priority (3)

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BR0400237-7A BRPI0400237A (pt) 2004-01-16 2004-01-16 Processo de esterelização a vácuo com aplicação de vapor de uma mistura de ácido peracético com peróxido de hidrogênio e plasma de gás residual de ar atmosférico excitado por descarga elétrica dc pulsada; dispositivos e métodos operacionais utilizados no processo de esterilização
BRPI0400237-7 2004-01-16
PCT/EP2005/000357 WO2005067984A1 (fr) 2004-01-16 2005-01-14 Procede et dispositifs de traitement de sterilisation sous vide

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EP (1) EP1735014B1 (fr)
KR (1) KR101233519B1 (fr)
CN (1) CN100512881C (fr)
AT (1) ATE478689T1 (fr)
AU (1) AU2005205050B2 (fr)
BR (2) BRPI0400237A (fr)
CA (1) CA2524566C (fr)
DE (1) DE602005023137D1 (fr)
EA (1) EA009437B1 (fr)
ES (1) ES2357492T3 (fr)
HK (1) HK1089704A1 (fr)
HR (1) HRP20100609T1 (fr)
PL (1) PL1735014T3 (fr)
PT (1) PT1735014E (fr)
RS (1) RS51624B (fr)
WO (1) WO2005067984A1 (fr)
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Cited By (15)

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US20060173209A1 (en) * 2004-07-28 2006-08-03 Peragen Systems Inc. Continuous Process For On Site And On Demand Production Of Aqueous Peracetic Acid
US20100168499A1 (en) * 2006-08-18 2010-07-01 Drexel University Method and device for air disinfection and sterilization
EP2425901A1 (fr) * 2010-06-30 2012-03-07 Kohlhoff Hygiene GmbH Dispositif de nettoyage pour gants et tabliers à cotte de mailles
US20150313250A1 (en) * 2012-09-27 2015-11-05 Saraya Co., Ltd. Sterilization method and device
US20170360974A1 (en) * 2016-06-21 2017-12-21 Medident Technologies Inc. Plasmaclave Device
JP2018008051A (ja) * 2016-06-30 2018-01-18 エシコン・インコーポレイテッドＥｔｈｉｃｏｎ， Ｉｎｃｏｒｐｏｒａｔｅｄ 内視鏡を滅菌するための装置及び方法
US20190167078A1 (en) * 2017-12-04 2019-06-06 Ethicon, Inc. Sterilization package
JP2019520872A (ja) * 2016-07-11 2019-07-25 プラズマップ カンパニー，リミテッド 密封パウチ及び真空コンテナを用いる滅菌装置
KR20190121013A (ko) * 2018-04-17 2019-10-25 주식회사 플라즈맵 카트리지 및 이를 이용한 멸균장치
US10905786B2 (en) 2017-03-27 2021-02-02 Regeneron Pharmaceuticals, Inc. Sterilisation method
US20210322606A1 (en) * 2020-04-19 2021-10-21 Martin E. Toomajian Method and device for disinfection of healthcare personal protective equipment by direct application of a dry plasma field
US11266760B2 (en) 2017-04-25 2022-03-08 Plasmapp Co., Ltd. Cartridge and sterilizing device using same
EP3970758A1 (fr) * 2020-09-22 2022-03-23 Gea Procomac S.p.A. Unité et procédé de stérilisation d'articles tels que des capsules, paraisons, récipients
US11696967B2 (en) 2016-06-30 2023-07-11 Asp Global Manufacturing Gmbh Apparatus and method for sterilizing endoscope
US11712490B2 (en) 2017-04-25 2023-08-01 Plasmapp Co., Ltd. Sterilization apparatus

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DE102007029282B4 (de) * 2007-06-22 2011-10-20 Dino Anlagen- Und Maschinenbau Gmbh Verfahren und Vorrichtung zum Sterilisieren mindestens eines Arbeitsmittels
AU2008271669B2 (en) * 2007-07-02 2012-02-09 Buhler Barth Gmbh Process for surface pasteurization and sterilization of food pieces
JP4408957B2 (ja) * 2007-09-27 2010-02-03 聡 井川 殺菌方法および装置
WO2011047127A1 (fr) 2009-10-15 2011-04-21 Minntech Corporation Système de désinfection de pièce par brumisation
EP2506884B1 (fr) 2009-12-03 2015-02-18 Minntech Corporation Récipient pour la décontamination d' un appareil médical avec de brouillard
RU2428385C1 (ru) * 2009-12-25 2011-09-10 Закрытое Акционерное Общество "Твин Трейдинг Компани" Способ обеззараживания осадков сточных вод
US9364571B2 (en) 2011-04-01 2016-06-14 Goa Teknoloji Danismanlik Elektronik, Imalat Ticaret Ithalat Ihracat A.S. Sterilization with in-line concentrating and injection of hydrogen peroxide
CN102241286B (zh) * 2011-05-12 2013-04-10 楚天科技股份有限公司 隧道式灭菌干燥机用具有在线灭菌功能的烘箱
EP2714101B1 (fr) 2011-05-27 2016-05-18 Mar Cor Purification, Inc. Système de dekontamination et procèdè
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