US20050245889A1 - Disposable cassette - Google Patents

Disposable cassette Download PDF

Info

Publication number
US20050245889A1
US20050245889A1 US10/525,668 US52566805A US2005245889A1 US 20050245889 A1 US20050245889 A1 US 20050245889A1 US 52566805 A US52566805 A US 52566805A US 2005245889 A1 US2005245889 A1 US 2005245889A1
Authority
US
United States
Prior art keywords
disposable cassette
accordance
actuators
channels
regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/525,668
Other languages
English (en)
Inventor
Juergen Haecker
Stephan Frey
Uwe Lapp
Paul Jahn
Stephan Oesterreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31724146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20050245889(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Assigned to FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH reassignment FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FREY, STEPHAN, JAHN, PAUL, HAECKER, JUERGEN, LAPP, UWE, OESTERREICH, STEPHAN
Publication of US20050245889A1 publication Critical patent/US20050245889A1/en
Priority to US12/805,124 priority Critical patent/US8202489B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16—Making multilayered or multicoloured articles
    • B29C45/1676—Making multilayered or multicoloured articles using a soft material and a rigid material, e.g. making articles with a sealing part
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0054—Special features particularities of the flexible members
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/748—Machines or parts thereof not otherwise provided for
    • B29L2031/7496—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/748—Machines or parts thereof not otherwise provided for
    • B29L2031/7506—Valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/755—Membranes, diaphragms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards

Definitions

  • the invention relates to a disposable cassette in accordance with the preamble of claim 1 .
  • Disposable plastic articles with fluid carrying channels are frequently used in medical equipment.
  • Corresponding cassette systems have proven their worth here as alternatives to conventional hose systems.
  • the corresponding fluid paths are formed in these cassette systems.
  • the fluid flowing through the fluid paths is acted on by means of corresponding actuators.
  • valves are used via which the fluid paths are switched open or are closed.
  • pumps for the transport of the fluid are integrated in such cassette systems.
  • disposable cassettes are already known in which a rigid part is provided into which channels and chambers are formed. This rigid part is covered by a continuously flexible film.
  • the known cassette systems frequently have a very complex design. On the one hand, they have rigid boundaries and, on the other hand, they have regions for the installation of actuator elements.
  • the systems used in analysis technology are usually made in three layers in that, in addition to two rigid layers, a flexible film is also provided through which the fluid flow can be manipulated at exposed regions.
  • a generic disposable cassette for use in analysis technology is already known from WO 02/24320A1 which consists of a first part in which channel structures are cut-out in the surface. This first part is sealingly covered via a second part. One of the two parts is made as a flexible part. Engagement regions for actuator elements are provided at pre-determined points of this disposable cassette.
  • the forming of one of the two parts of the already known disposable cassette as a flexible part is, however, disadvantageous since the stability and also the functionality of the individual sealing function of the total disposable cassette is not always ensured.
  • the first part and/or the second part are, for the larger part, rigid in design.
  • respective flexibly designed regions can be provided, With the rigid and flexible regions each being manufactured in one piece using two-component injection molding technology.
  • the rigid part can thereby be manufactured as one component with the integrated flexible regions and can thus be manufactured in a cost-favorable manner in a single production step.
  • a high stability of the total component results here in comparison with the prior art.
  • a more compact design also results due to the fewer layers required with respect to other disposable cassettes of a more complex design in analysis technology.
  • the flexible regions can be formed in the engagement regions for the actuator elements.
  • At least some of the channels can consist of flexible material.
  • Valves, membrane pumps, restrictors or metering valves can be used as actuators.
  • the region of the channels in which the actuators are coupled is advantageously made shallower and with a larger channel cross-section.
  • the required actuator forces for the deflection of the flexible region can be reduced by these aspects.
  • Both liquids and gases can be the fluid for the flowing through of the channels.
  • the cassette in accordance with the invention is preferably used in medical engineering in the conveying and/or metering of fluids. It is particularly suitable for conveying and/or metering in analysis technology.
  • FIG. 1 a schematic, perspective detailed view of a partly sectioned disposable cassette in accordance with a variant of the present invention
  • FIG. 2 a schematic representation of the arrangement of different actuators along a channel in a disposable cassette in accordance with FIG. 1 ;
  • FIG. 3 a perspective representation of a further embodiment of the disposable cassette in accordance with the invention as a cut-out detail.
  • a channel structure 14 is formed for the purpose of fluid guidance in a first part 12 and is tightly closed by a second part 16 , a type of rigid cover plate.
  • a partial region 18 of the first part 12 which otherwise consists of a rigid plastic material, is made as an integral component of the part 12 in a flexible elastomer material.
  • This elastomer region 18 which is made in one piece, serves as a pump calotte.
  • the pump calotte is moved to and fro by being acted on by means of a corresponding actuator, which is not shown in more detail here in FIG. 1 , such that the space 20 sealingly surrounded by the pump calotte 18 is reduced or enlarged in volume.
  • This space 20 which is in communication with the channel 14 , is filled with the fluid to be conveyed so that the fluid can be conveyed accordingly by a corresponding deflection of the elastomer component 18 , i.e. the pump calotte.
  • This conveying principle corresponds precisely to that of a membrane pump and is already known as a principle both in analysis technology and overall in medical engineering.
  • valves 22 and 24 are provided at the inlet and outlet sides respectively in the channel 14 next to the flexible region 18 which serves as a pump calotte, said valves being attached as backflow valves which are closed and opened alternately in tact with the pump.
  • These regions can also be made as correspondingly flexible partial regions of the otherwise rigid first part 12 of the disposable cassette 10 .
  • the first part 12 can be produced as a one-piece element using two-component injection molding technology.
  • FIG. 3 Another embodiment variant of a disposable cassette 10 ′ is realized in FIG. 3 .
  • a channel structure 14 which is downwardly tightly closed by the second part 16 , which is made as a rigid cover plate, is formed in a first part 12 of the disposable cassette 10 ′ for the purpose of fluid guidance.
  • the channel 14 can be opened and closed in the flow direction by a channel section 30 which is made in a flexible elastomer material and which was manufactured in one piece with the first part 12 by two-component injection molding technology.
  • the resilient region 30 is an integral component of the otherwise rigid first part 12 due to this one-piece formation. It is thereby connected to it firmly, on the one hand, and in a liquid-tight manner, on the other hand.
  • the channel 14 is made continuously as a flexible elastomer part.
  • the channel can be made as a flexible elastomer part only in the region of the valve itself, while the other channel regions are formed by means of the rigid material of the first part 12 .
  • the force discharge onto the flexible elastomer region can take place in a variety of ways. On the one hand, in a tactile manner via a plunger 35 , as shown in FIG. 3 . On the other hand, however, also directly pneumatically via compressed air. In this case, a sealing lip would have to be provided around the valve on the rear side of the first part 12 .
  • the force can also be applied indirectly pneumatically or hydraulically via a small pressure cushion which would have to be provided on the instrument side. It is particularly advantageous here for a sealing function already being able to be achieved with very small valve closing forces.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Reciprocating Pumps (AREA)
  • Liquid Crystal (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
US10/525,668 2002-08-28 2003-08-18 Disposable cassette Abandoned US20050245889A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/805,124 US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10239597.7 2002-08-28
DE10239597A DE10239597B4 (de) 2002-08-28 2002-08-28 Einwegkassette
PCT/EP2003/009128 WO2004024326A1 (de) 2002-08-28 2003-08-18 Einwegkassette

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/805,124 Continuation US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Publications (1)

Publication Number Publication Date
US20050245889A1 true US20050245889A1 (en) 2005-11-03

Family

ID=31724146

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/525,668 Abandoned US20050245889A1 (en) 2002-08-28 2003-08-18 Disposable cassette
US12/805,124 Expired - Lifetime US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/805,124 Expired - Lifetime US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Country Status (10)

Country Link
US (2) US20050245889A1 (es)
EP (1) EP1534431B1 (es)
JP (1) JP2006503204A (es)
KR (1) KR101057845B1 (es)
CN (2) CN1678396A (es)
AT (1) ATE423621T1 (es)
AU (1) AU2003282002A1 (es)
DE (2) DE10239597B4 (es)
ES (1) ES2319641T3 (es)
WO (1) WO2004024326A1 (es)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060235335A1 (en) * 2005-03-30 2006-10-19 Roche Molecular Systems, Inc. Device having a self sealing fluid port
US20130037139A1 (en) * 2009-12-17 2013-02-14 Silicon Biosystems S.P.A. Micro-Fluidic System
CN109763966A (zh) * 2019-03-03 2019-05-17 浙江师范大学 一种串联腔体压电驱动的间接式药物输送泵
CN110131141A (zh) * 2019-03-03 2019-08-16 浙江师范大学 一种易维护的自调节式压电药物输送泵
US10682457B2 (en) 2015-04-30 2020-06-16 Ulrich Gmbh & Co. Kg Device for transferring a fluid
US11642818B2 (en) 2016-07-13 2023-05-09 Nikon Corporation Fluidic device, method of manufacturing fluidic device, and valve for fluidic device

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10330804A1 (de) 2003-07-08 2005-04-28 Fresenius Medical Care De Gmbh Einwegkassette
DE10330803B4 (de) * 2003-07-08 2005-11-17 Fresenius Medical Care Deutschland Gmbh Einwegkassette und deren Verwendung
EP1905514A1 (en) * 2006-09-30 2008-04-02 Roche Diagnostics GmbH Device having a reversibly closable fluid valve
US8256285B2 (en) 2007-08-21 2012-09-04 BELIMO Holding, AG Flow sensor including a base member with a resilient region forming a flow channel and a cover member covering the flow channel
US20110049054A1 (en) * 2007-09-20 2011-03-03 Verenium Corporation Wastewater treatment system
DE102009037845A1 (de) 2009-08-18 2011-04-14 Fresenius Medical Care Deutschland Gmbh Einwegelement, System zum Pumpen sowie Verfahren zum Pumpen einer Flüssigkeit
CH702418A1 (fr) * 2009-12-23 2011-06-30 Jean-Denis Rochat Cassette jetable de pompe de perfusion à usage médical et son procédé de fabrication.
DE102010020838A1 (de) 2010-05-18 2011-11-24 Fresenius Medical Care Deutschland Gmbh Ventilanordnung zur Verwendung in einem extrakorporalen Blutkreislauf sowie Verfahren
EP2653285B1 (en) * 2012-04-16 2018-10-10 SABIC Global Technologies B.V. Providing micro-channels in a plastic substrate
US9592507B2 (en) * 2012-06-22 2017-03-14 Abbott Point Of Care Inc. Integrated cartridge housings for sample analysis
JP6855154B2 (ja) * 2014-09-02 2021-04-07 キヤノンメディカルシステムズ株式会社 核酸検出カセット
CN107002005B (zh) 2014-09-02 2021-05-11 东芝医疗系统株式会社 核酸检测盒
CN109012768B (zh) * 2017-06-09 2021-11-19 国家纳米科学中心 微流控液体单向流动控制结构、芯片及方法
AT520605B1 (de) * 2017-11-10 2020-03-15 Erba Tech Austria Gmbh Sensorkassette
JP7167434B2 (ja) * 2017-12-13 2022-11-09 株式会社ニコン 流体デバイス、リザーバー供給システムおよび流路供給システム

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585623A (en) * 1984-02-27 1986-04-29 Allelix Inc. Device for performing quantitative chemical and immunochemical assays
US4978502A (en) * 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5660728A (en) * 1993-10-04 1997-08-26 Research International, Inc. Micromachined fluid handling apparatus with filter
US6261066B1 (en) * 1997-05-12 2001-07-17 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Micromembrane pump
US20020081222A1 (en) * 2000-11-06 2002-06-27 Nanostream, Inc. Uni-directional flow microfluidic components
US20030051339A1 (en) * 2000-03-31 2003-03-20 Wolfgang Ehrfeld Method for assembling cassette-loaded microcomponents
US7238325B2 (en) * 2000-09-22 2007-07-03 Kawamura Institute Of Chemical Research Very small chemical device and flow rate adjusting method therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098262A (en) * 1990-12-28 1992-03-24 Abbott Laboratories Solution pumping system with compressible pump cassette
JP2000508058A (ja) 1995-12-18 2000-06-27 ニューカーマンズ、アーモンド、ピー マイクロフルイディック弁及び集積マイクロフルイディックシステム
US6554789B1 (en) * 1997-02-14 2003-04-29 Nxstage Medical, Inc. Layered fluid circuit assemblies and methods for making them
DE29907933U1 (de) * 1999-05-04 1999-08-12 Georg Menshen Gmbh & Co Kg Schlitzschließventil für Behälteröffnungen
DE10046651A1 (de) * 2000-09-20 2002-04-04 Fresenius Medical Care De Gmbh Ventil
JP2002219697A (ja) 2000-09-22 2002-08-06 Kawamura Inst Of Chem Res バルブ機構を有するマイクロ流体デバイス及びその流量調節方法
DE10053441B4 (de) * 2000-10-27 2004-04-15 Fresenius Medical Care Deutschland Gmbh Disposablekassette mit Dichtungsmembran sowie Ventilaktor hierfür

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585623A (en) * 1984-02-27 1986-04-29 Allelix Inc. Device for performing quantitative chemical and immunochemical assays
US4978502A (en) * 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US5660728A (en) * 1993-10-04 1997-08-26 Research International, Inc. Micromachined fluid handling apparatus with filter
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6261066B1 (en) * 1997-05-12 2001-07-17 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Micromembrane pump
US20030051339A1 (en) * 2000-03-31 2003-03-20 Wolfgang Ehrfeld Method for assembling cassette-loaded microcomponents
US7238325B2 (en) * 2000-09-22 2007-07-03 Kawamura Institute Of Chemical Research Very small chemical device and flow rate adjusting method therefor
US20020081222A1 (en) * 2000-11-06 2002-06-27 Nanostream, Inc. Uni-directional flow microfluidic components

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060235335A1 (en) * 2005-03-30 2006-10-19 Roche Molecular Systems, Inc. Device having a self sealing fluid port
US20130037139A1 (en) * 2009-12-17 2013-02-14 Silicon Biosystems S.P.A. Micro-Fluidic System
US10060554B2 (en) * 2009-12-17 2018-08-28 Menarini Silicon Biosystems S.P.A. Micro-fluidic system
US10682457B2 (en) 2015-04-30 2020-06-16 Ulrich Gmbh & Co. Kg Device for transferring a fluid
US11642818B2 (en) 2016-07-13 2023-05-09 Nikon Corporation Fluidic device, method of manufacturing fluidic device, and valve for fluidic device
CN109763966A (zh) * 2019-03-03 2019-05-17 浙江师范大学 一种串联腔体压电驱动的间接式药物输送泵
CN110131141A (zh) * 2019-03-03 2019-08-16 浙江师范大学 一种易维护的自调节式压电药物输送泵

Also Published As

Publication number Publication date
EP1534431B1 (de) 2009-02-25
KR20050046737A (ko) 2005-05-18
AU2003282002A1 (en) 2004-04-30
JP2006503204A (ja) 2006-01-26
DE10239597A1 (de) 2004-03-18
US20110070132A1 (en) 2011-03-24
DE10239597B4 (de) 2005-03-17
CN1678396A (zh) 2005-10-05
US8202489B2 (en) 2012-06-19
ES2319641T3 (es) 2009-05-11
ATE423621T1 (de) 2009-03-15
CN103480311B (zh) 2015-08-05
CN103480311A (zh) 2014-01-01
DE50311225D1 (de) 2009-04-09
KR101057845B1 (ko) 2011-08-19
EP1534431A1 (de) 2005-06-01
WO2004024326A1 (de) 2004-03-25

Similar Documents

Publication Publication Date Title
US8202489B2 (en) Disposable cassette
US20020155010A1 (en) Microfluidic valve with partially restrained element
US20120298233A1 (en) Microfluidic component for manipulating a fluid, and microfluidic chip
US20090314970A1 (en) Mechanically-Actuated Microfluidic Pinch Valve
DE60120230D1 (de) Durch mikrofabrikation hergestellte fluidikschaltkreiselemente und -anwendungen
US8080220B2 (en) Thermal bend actuated microfluidic peristaltic pump
US7981386B2 (en) Mechanically-actuated microfluidic valve
US20090317272A1 (en) MEMS Integrated Circuit Comprising Peristaltic Microfluidic Pump
EP3033526B1 (en) Microfluidic device with valve
US20140134002A1 (en) Microfluidic peristaltic pump, method and pumping system
AU2017208193A1 (en) Fluidic manifold
US20090317302A1 (en) Microfluidic System Comprising MEMS Integrated Circuit
CN103797288A (zh) 双稳态流体阀
US9244465B2 (en) Metering system, housing part for a metering unit and metering unit
JP7016384B2 (ja) マニホールド、およびマニホールドを備えた装置
US7293580B2 (en) Valve
JP6224296B2 (ja) 逆止弁及びダイヤフラムポンプ
WO2009152547A1 (en) Bonded microfluidics system comprising cmos-controllable microfluidic devices
US20240125315A1 (en) Microfluidic pump
US20070003420A1 (en) Micropump and adhesive-free method for joining two substrates
US20090317301A1 (en) Bonded Microfluidics System Comprising MEMS-Actuated Microfluidic Devices
JPH11304022A (ja) 切換弁
JP2009121242A (ja) ダイアフラム型液体搬送器
JPS5899507A (ja) 弁装置

Legal Events

Date Code Title Description
AS Assignment

Owner name: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HAECKER, JUERGEN;FREY, STEPHAN;LAPP, UWE;AND OTHERS;REEL/FRAME:016753/0160;SIGNING DATES FROM 20050110 TO 20050213

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION