CN1678396A - 一次性盒子 - Google Patents
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- CN1678396A CN1678396A CNA038203693A CN03820369A CN1678396A CN 1678396 A CN1678396 A CN 1678396A CN A038203693 A CNA038203693 A CN A038203693A CN 03820369 A CN03820369 A CN 03820369A CN 1678396 A CN1678396 A CN 1678396A
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- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/16—Making multilayered or multicoloured articles
- B29C45/1676—Making multilayered or multicoloured articles using a soft material and a rigid material, e.g. making articles with a sealing part
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/0009—Special features
- F04B43/0054—Special features particularities of the flexible members
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
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- B29L2031/7496—Pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29L2031/748—Machines or parts thereof not otherwise provided for
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/755—Membranes, diaphragms
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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Abstract
本发明涉及一种一次性盒子,用于在分析技术中使用,它由至少一个第一部分和第二部分组成,同时具有致动器部件的结合区域;在所述第一部分中沟道结构在平面中构造,所述第二部分以密封方式覆盖着所述第一部分,所述结合区域被设置在预定点处。根据本发明,第一部分和/或第二部分很大程度上以坚硬的方式构造;然而,它们具有柔性地制成的区域,同时应用双组分注射模压技术把坚硬的和柔性的区域制成在一个零件中。
Description
本发明涉及依据权利要求1前序的一次性盒子。
具有流体输送沟道的一次性塑料物品常被用于医疗设备中。相应的盒子系统作为惯用的软管系统的替代物已证明了它们的价值。所述相应的流体沟道被制成于这些盒子系统中。流过流体沟道的流体受到相应的致动器的作用。例如,应用了使流体沟道被切换成开启或关闭的多个阀。另一方面,用于输送流体的泵被一体于这种盒子系统中。在医疗应用领域中,已知晓一次性盒子中设有坚硬部分,并且在其中设有沟道及腔。该坚硬部分被连续柔性薄膜所覆盖。
在分析技术领域中,所述已知的盒子系统经常具有非常复杂的结构。一方面,它们具有坚硬的边缘,而另一方面,它们具有安装致动器部件的多个区域。应用于分析技术中的系统通常制在三层中,除了两个坚硬层外,还设有柔性的薄膜,通过所述柔性的薄膜可在暴露的区域操纵流体流通。
已从WO 02/24320A1中知晓了用于分析技术中的普通的一次性盒子,它包含第一部分,在第一部分中沟道结构在表面中被切出。该第一部分被第二部分密封地覆盖。两个部分中的一个被制成柔性部分。致动器部件的结合区域被设置在该一次性盒子的预定点处。然而,已知的一次性盒子的两个部分中的一个制成为柔性部分是不利的,因为不能一直保证整个一次性盒子的单个密封功能的稳定性以及功能性。
因此本发明的目的是进一步开发通用的一次性盒子,一方面使得它具有简单的结构,而另一方面它自身具有稳定的结构。
根据本发明这个目的通过具有权利要求1的特点的一次性盒子来解决。因此,所述第一部分和/或所述第二部分的较大部分是坚硬的结构。然而,可制有个别的柔性地构造的区域,同时应用双组分注射模压技术把每个坚硬的区域及柔性的区域制在一个零件中。由此坚硬的部分可与一体的柔性的部分制成一个部件,并因此可以有利的成本的方式在单个生产步骤中制成。另一方面,此处与现有技术相比获得了整体部件的高稳定性。由于相对于分析技术中其它更复杂结构的一次性盒子仅需要更少的层数,因而也获得了更紧凑的结构。
本发明的有利方面列举于从属权利要求中。
因此,所述柔性区域可制成于致动器部件的结合区域中。
另一方面,至少某些沟道可由柔性材料构成。
阀、隔膜泵、节流器或节流阀可被用作致动器。
各致动器在其中连接的沟道区域被有利地制得较薄并具有较大的沟道横截面。通过这些方面可减小使柔性区域偏离的所需致动器作用力。
液体及气体两者可以是流过沟道的流体。
根据本发明的所述盒子最好应用于医疗工程的流体输送和/或计量方面。它特别适用于分析技术中的输送和/或计量。
将参考附图中所示的各实施例来更详细地解释本发明的其它细节及优点。所示为:
图1:是根据本发明变型的局剖的一次性盒子的简略立体视图;
图2:是各不同的致动器沿着根据图1的一次性盒子的沟道布置的简略图;和
图3:是作为切割细节的根据本发明的一次性盒子的其它实施例的简略图。
在图1中部分地表示的一次性盒子10中,用来引导流体的沟道结构14被制成在第一部分12中,并被坚硬盖板式的第二部分16紧密地封闭。另外由坚硬的塑料材料构成的第一部分12的部分区域18被制成为用柔性的弹性材料制造的部分12的一体部件。被制成一个零件的该弹性区域18用作泵的帽罩。所述泵的帽罩在相应的致动器的作用下往复移动,这点在图1中没有更详细显示,因此被泵的帽罩18密封地包围的空间20在体积上被减小或扩大。与沟道14连通的该空间20填充有要输送的流体,因此,通过弹性部件18,即泵的帽罩的相应偏转可使所述流体被输送。该输送原理精确地对应于隔膜泵的原理,并已知晓作为分析技术及全部医疗工程两者中的原理。在图2中显示了阀22及24分别设置在沟道14的入口侧和出口侧,与用作泵的帽罩的柔性区域18相邻,所述各阀被连接成回流阀,所述回流阀用所述泵间歇交替地关闭及开启。这些区域也可被制成作为一次性盒子10的其它坚硬的第一部分12的相应部分的柔性区域。第一部分12可应用双组分注射模压技术制成单件式元件。
在图3中了解到一次性盒子10′的另一个实施例变型。用于引导流体的沟道结构14被制成在一次性盒子10′的第一部分12中,被制成作为坚硬盖板的第二部分16向下紧密地封闭沟道结构14。沟道14可在流通方向上被沟道部分30开启和关闭,沟道30由柔性的弹性材料制成并通过双组分注射模压技术与第一部分12制成一个零件。由于该一个零件的组织结构,弹性区域30是另外的坚硬的第一部分12的一体部分。由此,一方面,它被坚固地连接于坚硬的第一部分12,而另一方面处于液密状态。
对于关闭这样一种阀来说,在双向箭头方向上引导柱塞35的力作用在弹性区域30的后侧是足够的。由于这个力卸荷导致沟道14被关闭。通过撤去关闭力,即在双向箭头方向上撤离柱塞35而使阀开启,致使因其弹性材料性质而使区域30的形状再次恢复成初始的沟道形状。
在此处所示的实施例中,沟道14被连续地制成柔性的弹性部分。然而,可替换地,沟道仅在阀本身的区域中被制成柔性的弹性部分,而其它的沟道区域用第一部分12的坚硬材料制成。可以多种方法进行在柔性的弹性部分上的力卸荷。一方面,如图3中所示,利用柱塞35的间歇方式,然而,另一方面,利用压缩空气直接气动方式。在此情况下,必须在第一部分12的后侧上设置围绕阀的密封突缘。最终,力还可经小压力垫间接靠气动或液压施加,所述小压力垫必须被设置在所述装置侧。在这里,特别有利的是已经能够用非常小的阀关闭力实现密封功能。
Claims (7)
1.由至少一个在其中在平面上切割出沟道结构的第一部分和以密封方式覆盖着所述第一部分的第二部分组成的一次性盒子,用于致动器部件的结合区域设置在预定点处,
其特征在于:
所述第一部分和/或所述第二部分大部分制成坚硬的,然而,它们具有柔性地制成的区域,同时应用双组分注射模压技术使所述坚硬的与柔性的区域被制成在一个零件中。
2.根据权利要求1的一次性盒子,其特征在于:所述柔性的区域被制成在致动器部件的结合区域中。
3.根据权利要求1或2的一次性盒子,其特征在于:至少某些沟道由柔性的材料组成。
4.根据权利要求1至3中任一项的一次性盒子,其特征在于:阀被用作致动器。
5.根据权利要求1至3中任一项的一次性盒子,其特征在于:隔膜泵被用作致动器。
6.根据权利要求1至3中任一项的一次性盒子,其特征在于:节流器或计量阀被用作致动器。
7.根据权利要求1至6中任一项的一次性盒子,其特征在于:连接了各致动器的沟道区域被制得较薄并具有较大的沟道横截面。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310407456.5A CN103480311B (zh) | 2002-08-28 | 2003-08-18 | 一次性盒子 |
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DE10239597.7 | 2002-08-28 | ||
DE10239597A DE10239597B4 (de) | 2002-08-28 | 2002-08-28 | Einwegkassette |
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CN201310407456.5A Division CN103480311B (zh) | 2002-08-28 | 2003-08-18 | 一次性盒子 |
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CN1678396A true CN1678396A (zh) | 2005-10-05 |
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CNA038203693A Pending CN1678396A (zh) | 2002-08-28 | 2003-08-18 | 一次性盒子 |
CN201310407456.5A Expired - Lifetime CN103480311B (zh) | 2002-08-28 | 2003-08-18 | 一次性盒子 |
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CN201310407456.5A Expired - Lifetime CN103480311B (zh) | 2002-08-28 | 2003-08-18 | 一次性盒子 |
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US (2) | US20050245889A1 (zh) |
EP (1) | EP1534431B1 (zh) |
JP (1) | JP2006503204A (zh) |
KR (1) | KR101057845B1 (zh) |
CN (2) | CN1678396A (zh) |
AT (1) | ATE423621T1 (zh) |
AU (1) | AU2003282002A1 (zh) |
DE (2) | DE10239597B4 (zh) |
ES (1) | ES2319641T3 (zh) |
WO (1) | WO2004024326A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101784343B (zh) * | 2007-08-21 | 2013-01-23 | 贝利莫控股公司 | 流量传感器及其制造方法 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10330804A1 (de) | 2003-07-08 | 2005-04-28 | Fresenius Medical Care De Gmbh | Einwegkassette |
DE10330803B4 (de) * | 2003-07-08 | 2005-11-17 | Fresenius Medical Care Deutschland Gmbh | Einwegkassette und deren Verwendung |
EP1707267A1 (en) * | 2005-03-30 | 2006-10-04 | F. Hoffman-la Roche AG | Device having a self sealing fluid port |
EP1905514A1 (en) * | 2006-09-30 | 2008-04-02 | Roche Diagnostics GmbH | Device having a reversibly closable fluid valve |
US20110049054A1 (en) * | 2007-09-20 | 2011-03-03 | Verenium Corporation | Wastewater treatment system |
DE102009037845A1 (de) | 2009-08-18 | 2011-04-14 | Fresenius Medical Care Deutschland Gmbh | Einwegelement, System zum Pumpen sowie Verfahren zum Pumpen einer Flüssigkeit |
IT1397820B1 (it) * | 2009-12-17 | 2013-02-04 | Silicon Biosystems Spa | Sistema microfluidico |
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2002
- 2002-08-28 DE DE10239597A patent/DE10239597B4/de not_active Expired - Fee Related
-
2003
- 2003-08-18 ES ES03773609T patent/ES2319641T3/es not_active Expired - Lifetime
- 2003-08-18 AU AU2003282002A patent/AU2003282002A1/en not_active Abandoned
- 2003-08-18 AT AT03773609T patent/ATE423621T1/de not_active IP Right Cessation
- 2003-08-18 US US10/525,668 patent/US20050245889A1/en not_active Abandoned
- 2003-08-18 KR KR1020057002974A patent/KR101057845B1/ko not_active IP Right Cessation
- 2003-08-18 WO PCT/EP2003/009128 patent/WO2004024326A1/de active Application Filing
- 2003-08-18 JP JP2004535103A patent/JP2006503204A/ja active Pending
- 2003-08-18 DE DE50311225T patent/DE50311225D1/de not_active Expired - Lifetime
- 2003-08-18 CN CNA038203693A patent/CN1678396A/zh active Pending
- 2003-08-18 EP EP03773609A patent/EP1534431B1/de not_active Expired - Lifetime
- 2003-08-18 CN CN201310407456.5A patent/CN103480311B/zh not_active Expired - Lifetime
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2010
- 2010-07-13 US US12/805,124 patent/US8202489B2/en not_active Expired - Lifetime
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CN101784343B (zh) * | 2007-08-21 | 2013-01-23 | 贝利莫控股公司 | 流量传感器及其制造方法 |
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EP1534431B1 (de) | 2009-02-25 |
KR20050046737A (ko) | 2005-05-18 |
AU2003282002A1 (en) | 2004-04-30 |
JP2006503204A (ja) | 2006-01-26 |
DE10239597A1 (de) | 2004-03-18 |
US20050245889A1 (en) | 2005-11-03 |
US20110070132A1 (en) | 2011-03-24 |
DE10239597B4 (de) | 2005-03-17 |
US8202489B2 (en) | 2012-06-19 |
ES2319641T3 (es) | 2009-05-11 |
ATE423621T1 (de) | 2009-03-15 |
CN103480311B (zh) | 2015-08-05 |
CN103480311A (zh) | 2014-01-01 |
DE50311225D1 (de) | 2009-04-09 |
KR101057845B1 (ko) | 2011-08-19 |
EP1534431A1 (de) | 2005-06-01 |
WO2004024326A1 (de) | 2004-03-25 |
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