US20050215975A1 - Irreversibly closable flow control clamp - Google Patents

Irreversibly closable flow control clamp Download PDF

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Publication number
US20050215975A1
US20050215975A1 US10/501,571 US50157105A US2005215975A1 US 20050215975 A1 US20050215975 A1 US 20050215975A1 US 50157105 A US50157105 A US 50157105A US 2005215975 A1 US2005215975 A1 US 2005215975A1
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US
United States
Prior art keywords
flow control
legs
control clamp
closed position
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/501,571
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English (en)
Inventor
Jean-Marie Mathias
Gianni Di Stefani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fenwal Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/501,571 priority Critical patent/US20050215975A1/en
Application filed by Individual filed Critical Individual
Assigned to BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC. reassignment BAXTER HEALTHCARE S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DI STEFANI, GIANNI, MATHIAS, JEAN-MARIE
Publication of US20050215975A1 publication Critical patent/US20050215975A1/en
Assigned to FENWAL, INC. reassignment FENWAL, INC. PATENT ASSIGNMENT Assignors: BAXTER INTERNATIONAL INC.
Assigned to MORGAN STANLEY & CO. INCORPORATED reassignment MORGAN STANLEY & CO. INCORPORATED FIRST-LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Assignors: FENWAL HOLDINGS, INC., FENWAL, INC.
Assigned to MORGAN STANLEY & CO. INCORPORATED reassignment MORGAN STANLEY & CO. INCORPORATED SECOND-LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Assignors: FENWAL HOLDINGS, INC., FENWAL, INC.
Priority to US12/401,332 priority patent/US8517970B2/en
Assigned to FENWAL, INC. reassignment FENWAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAXTER HEALTHCARE S.A.
Priority to US12/635,440 priority patent/US8262639B2/en
Priority to US13/196,668 priority patent/US8956339B2/en
Assigned to FENWAL, INC., FENWAL HOLDINGS, INC. reassignment FENWAL, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MORGAN STANLEY & CO. LLC
Assigned to FENWAL, INC., FENWAL HOLDINGS, INC. reassignment FENWAL, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MORGAN STANLEY & CO. LLC
Priority to US14/601,416 priority patent/US9498616B2/en
Priority to US15/297,484 priority patent/US9789301B2/en
Priority to US15/693,597 priority patent/US10335586B2/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/28—Clamping means for squeezing flexible tubes, e.g. roller clamps
    • A61M39/284—Lever clamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/08—Tubes; Storage means specially adapted therefor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/02—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with tubular diaphragm
    • F16K7/04—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with tubular diaphragm constrictable by external radial force
    • F16K7/06—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with tubular diaphragm constrictable by external radial force by means of a screw-spindle, cam, or other mechanical means
    • F16K7/063—Lever clamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood

Definitions

  • the present relates to clamps for controlling the flow of liquid through a flexible tube. More particularly, the present invention relates to flow control clamps that can be substantially irreversibly secured in a closed position, thereby discouraging reopening of the flow path of the tube.
  • a disposable plastic container and tubing set or fluid circuit is typically used for collecting blood from a donor.
  • the disposable blood collection set includes a venipuncture needle for insertion into the arm of the donor.
  • the needle is attached to one end of a flexible plastic tube which provides a flow path for the blood.
  • the other end of the plastic tube is attached to one or more plastic bags or containers for collecting the withdrawn blood.
  • the blood collection set may also include a sampling sub-unit.
  • the sampling sub-unit allows for collection of a sample of blood, which sample can be used for testing of the blood.
  • the sample is obtained prior to the “main” collection of blood. Collecting the sample prior to the main collection reduces the risk that bacteria residing on the donor's skin where the needle is inserted (i.e., in particular, the small section of detached skin commonly referred to as the “skin plug”) will not enter the collection container and contaminate the blood collected for transfusion.
  • the blood sample which may include the skin plug, be diverted from the main collection container.
  • the collection sets described therein include a needle and a length of tubing, one end of which is attached to the needle and the other end of which is attached to one or more collection containers.
  • the tubing set also includes an additional line which is branched from the main line at a Y-connection site in the tubing set. The branched line is attached to a sampling pouch for collecting a smaller volume of blood from which samples may be obtained.
  • the sampling sub-unit may further include a pre-attached holder for receiving blood sample vials or tubes.
  • the holder is connected to the outlet port of the sampling pouch and includes a needle in the holder interior.
  • the needle pierces the rubber cap (septum) of the vial and blood from the sampling pouch is drawn into the vial.
  • the blood-filled vial is removed from the holder and the procedure may be repeated with as many vials as required.
  • the blood collection set described above also includes flow control clamps for controlling the flow of biological fluid (e.g., blood) through the set and to the sampling pouch and/or collection container.
  • Flow control clamps commonly used are the Roberts-type clamps, which are well known in the art.
  • the Roberts-type clamps are placed on the tubing line leading to the blood collection container and on the tubing line leading to the sampling pouch.
  • a Roberts-type clamp is typically made from a strip of plastic. The ends of the strip are curved toward each other to provide two “legs” which are adapted to engage each other in a snap-fit, spring relation.
  • the body of the clamp includes a pair of apertures through which the tubing passes.
  • the clamp further includes a pair of projections or tube contacting members which compress the tubing when the body of the clamp is depressed, thereby restricting flow through the tube.
  • Clamps of this type are generally described in U.S. Pat. Nos. 3,942,228, 6,089,527 and 6,113,062, all of which are incorporated herein by reference.
  • the clamps described in these patents also typically include means for locking the legs together and release means which, when actuated by the technician, disengages the locked legs of the flow control clamp. Disengagement of the ends decompresses the tube and permits fluid flow through the flow path.
  • the technician can control the flow of blood from the donor, diverting the blood to the desired container or sampling pouch, as necessary.
  • the line from the donor to the pouch is typically closed by the Roberts-type clamp, and remains closed as the sampling vials are filled.
  • technicians are further instructed to more permanently seal the line using metal clips or by heat-sealing the line in ways that will be known to those in the field. Sealing the sampling line substantially ensures that airborne bacteria or other contaminants that may enter the set through the sampling sub-unit do not contaminate the remainder of the set, including the needle and tube leading to the collection container.
  • the clips or heat seal provide a sterile barrier to the remainder of the set.
  • the present invention is directed to a flow control clamp that includes a flexible body.
  • the body has a first leg and a second leg disposed in a generally facing relationship.
  • the legs are moveable between a first spaced apart position and closed position.
  • the clamp includes two apertures in the body for receiving a flexible tube therethrough and between the legs.
  • the clamp further includes at least one tube contacting member carried by one of the legs for clamping the tube when the legs are in the closed position.
  • the first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.
  • FIG. 1 is a perspective view of a blood tubing set including a flow control clamp embodying the present invention
  • FIG. 2 is a perspective view of a flow control clamp embodying the present invention
  • FIG. 3 is a plan view of the flow control clamp of FIG. 2 taken from lines 3 - 3 of FIG. 2 ;
  • FIG. 4 is a plan view of the flow control clamp of FIG. 2 taken from lines 4 - 4 of FIG. 2 ;
  • FIG. 5 is a plan view of the flow control clamp of FIG. 2 from lines 5 - 5 ;
  • FIG. 6 is a plan view of the flow control clamp of FIG. 2 taken from lines 6 - 6 ;
  • FIG. 7 is a cross-sectional, side view of the flow control clamp embodying the present invention in the open position
  • FIG. 8 is a cross-sectional, side view of the flow control clamp embodying the present invention in the irreversibly locked position.
  • FIG. 9 is a side view of an alternative embodiment of the flow control clamp of the present invention.
  • FIG. 10 is a side view of another alternative embodiment of the flow control clamp of the present invention.
  • FIG. 11 is a side view of another alternative embodiment of the flow control clamp of the present invention.
  • FIG. 12 is a side view of another alternative embodiment of the flow control clamp of the present invention.
  • FIG. 1 depicts a blood collection set 10 of known type that is used in the collection of blood from a donor.
  • Tubing set 10 includes a venipuncture needle 12 and a length of tubing 14 .
  • Tubing 14 branches at Y-connector 16 into tubing segment 14 a and tubing segment 14 b.
  • Tubing segment 14 a provides a flowpath to a collection container 18 and tubing segment 14 b provides a flow path to a sampling pouch 20 .
  • the sampling pouch may also include a holder 21 for receiving a blood sampling vial or tube. (Also shown is a needle protector 15 for storing the needle after use.)
  • tubing segments 14 a and 14 b are passed through flow control clamps 22 and 30 which may be a standard Roberts-type clamp and an irreversibly closable flow control clamp embodying the present invention.
  • flow control clamps 22 and 30 which may be a standard Roberts-type clamp and an irreversibly closable flow control clamp embodying the present invention.
  • the terms “irreversibly” closed or closable means that the flow control clamp, once in the closed position, is not readily releasable from the closed position in the normal and intended mode of operation.
  • An “irreversibly” closed or closable flow control clamp can only be released from the closed and locked position by extraordinary and unintended manipulation of the clamp, including breakage of the clamp.
  • a flow control clamp that is “irreversibly” closed or closable includes no release members such as, but not limited to, those described in U.S. Pat. Nos. 3,942,228, 6,089,527, 6,113,062.
  • clamp 30 made in accordance with the present invention, once closed, remains irreversibly closed.
  • flow control clamp 30 of the present invention includes a generally curved, bent or otherwise non-linear body 34 (described in more detail below).
  • flow control clamp 30 may be made of any flexible, moldable, plastic material that can be steam sterilized.
  • flow control clamp 30 and body 34 should be made of a material that is strong, yet sufficiently flexible so that the clamp can be flexed and squeezed by the technician without breaking.
  • suitable materials are many of the known plastic materials typically used in the medical field, including, but not limited to polyoxymethylene and polypropylene. Most preferred of the above-identified materials is polyoxymethylene, such as the polyoxymethylene known as HostaformTM available from Ticona of Frankfurt, Germany.
  • ABS acrylonitrile, butadiene and styrene
  • flow control clamp 30 includes body 34 that has two legs 36 and 38 .
  • Legs 36 and 38 are disposed in a generally facing relationship relative to each other.
  • Legs 36 and 38 are initially in a spaced apart position as shown in FIG. 7 , and are movable from the spaced apart position toward each other and to a closed position.
  • Body 34 further includes apertures 40 and 44 for receiving a length of plastic tubing therethrough.
  • apertures 40 and 44 are preferably circular or oval-like and are entirely contained within body 34 of flow control clamp 30 .
  • the apertures completely enclose and surround the tubing at the point where the tubing extends through the apertures.
  • apertures need not completely surround the tube, but instead may include lateral slots, as described, for example, in U.S. Pat. No. 6,113,062. The lateral slots extend to the outer edge of the body so that during insertion of the tube, the clamp can be laterally slipped on the tube (as opposed to threading).
  • Flow control clamp 30 includes one or more tube contacting members 48 and 50 .
  • Tube contacting members 48 and 50 are carried by legs 36 and 38 , respectively.
  • tube contacting members 48 and 50 may be teeth-like projections which compress the tubing when the clamp is closed.
  • tube contacting members 48 and 50 may simply be blunt, oppositely facing surfaces.
  • two oppositely facing contacting members are shown in FIG. 2 and are preferred, it will be understood that flow control clamp 30 of the present invention may include only one tube contacting member carried by one of the legs 36 or 38 .
  • outer surface 52 of flow control clamp 30 is generally flat and smooth. However, outer surface 52 may include portions that are roughened or textured to provide some friction when contacted by the fingertips of the technician during operation. As shown in FIGS. 3 and 4 , outer surface 52 of body 34 includes ribbed portions 54 and 56 , which provide such a frictional surface for contacting by the fingers of the technician during closure and compression of flow control clamp 30 .
  • flow control clamp 30 is substantially free of any sharp corners or edges.
  • bends 58 , 60 and 62 in body 34 are not abrupt, sharp corners, but are gradually curved and rounded.
  • edges 63 of body 34 are preferably rounded or beveled.
  • a flow control clamp 30 that is substantially free of sharp corners and edges and is more rounded or beveled, like the flow control clamp shown in FIGS. 7 and 8 ensures that the flow control clamp will not puncture the packaging of blood processing sets, thereby maintaining sterility of the packaged set.
  • the blood processing set includes a sampling pouch of the type shown in FIG. 1
  • a flow control clamp 30 that provides an additional level of sterility maintenance by discouraging and perhaps even preventing the technician from reopening a previously closed clamp. This way, the sterility of the remainder of the blood processing set will be maintained and will not be compromised by bacteria from the outside environment.
  • legs 36 and 38 include surfaces that are disposed for irreversibly securing together legs 36 and 38 when the legs of flow control clamp 30 are moved from a spaced-apart position to the closed position, as shown in FIGS. 7 and 8 .
  • flow control clamp 30 may include means on the leg surfaces for interlocking legs 36 and 38 .
  • leg 36 of flow control clamp 30 may include a pair of spaced-apart walls 66 and 68 .
  • Spaced-apart walls 66 and 68 define a slot 70 for receiving an extension 72 carried by leg 38 .
  • One of the spaced-apart walls 66 or 68 may further include a lip 74 that projects into slot 72 , while the extension 72 includes a hook 76 that projects toward the wall 66 .
  • extension 72 is outwardly displaced by wall 66 and enters slot 70 .
  • hook 76 contacts lip 74
  • extension 72 is again outwardly displaced until it clears lip 74 .
  • extension 72 snaps forward toward wall 66 , and hook 76 engages lip 74 to effectively close and lock flow control clamp 30 .
  • Wall 68 prevents release or further outward displacement of extension 72 from the closed position, thereby resulting in an “irreversibly closed” flow control clamp 30 .
  • wall 68 is a thicker and a less flexible wall than, for example, wall 66 , thereby providing more strength to wall 68 and making it even more difficult to release extension 72 .
  • flow control clamp 30 does not include any tabs or other means for readily releasing extension 72 . Thus, flow control clamp 30 remains in the closed position.
  • FIGS. 9-12 include additional means for securing legs 36 and 38 in an “irreversibly closed” position.
  • extension 72 may include a peg
  • wall 66 includes a mating notch 84 for receiving peg 86 of extension 72 .
  • Extension 72 enters slot 70 in the manner generally described above, until peg 86 snaps into notch 84 .
  • Wall 68 again prevents outward movement of extension 72 , thereby retaining flow control clamp 30 in an “irreversibly closed” position.
  • FIG. 10 is an alternative embodiment where extension 72 includes a notch for receiving lip 74 of wall 66 .
  • lip 74 is located on wall 68 and is engaged by hook 76 , as previously described.
  • FIG. 12 shows yet another alternative embodiment of the flow control clamp 30 of the present invention wherein leg 36 includes a single wall 85 projecting toward the interior (i.e., toward leg 38 ) of the flow control clamp 30 .
  • Leg 38 includes an extension, likewise projecting toward the interior (i.e., and toward leg 36 ) of the flow control clamp 30 .
  • one of the legs may include a socket 86
  • the other of the legs may include a ball 88 for insertion into socket 86 .
  • flow control clamp 30 may be closed or locked in the “irreversibly closed” position.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
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US10/501,571 2002-01-31 2003-01-21 Irreversibly closable flow control clamp Abandoned US20050215975A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/501,571 US20050215975A1 (en) 2002-01-31 2003-01-21 Irreversibly closable flow control clamp
US12/401,332 US8517970B2 (en) 2002-01-31 2009-03-10 Irreversibly closable flow control clamp and fluid processing set
US12/635,440 US8262639B2 (en) 2002-01-31 2009-12-10 Irreversible flow control clamp
US13/196,668 US8956339B2 (en) 2002-01-31 2011-08-02 Irreversibly closable flow control clamp
US14/601,416 US9498616B2 (en) 2002-01-31 2015-01-21 Irreversibly closable flow control clamp
US15/297,484 US9789301B2 (en) 2002-01-31 2016-10-19 Irreversibly closable flow control clamp
US15/693,597 US10335586B2 (en) 2002-01-31 2017-09-01 Irreversibly closable flow control clamp

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35393002P 2002-01-31 2002-01-31
US10/501,571 US20050215975A1 (en) 2002-01-31 2003-01-21 Irreversibly closable flow control clamp
PCT/US2003/001758 WO2003063945A1 (en) 2002-01-31 2003-01-21 Irreversibly closable flow control clamp

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/001758 A-371-Of-International WO2003063945A1 (en) 2002-01-31 2003-01-21 Irreversibly closable flow control clamp

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/401,332 Continuation US8517970B2 (en) 2002-01-31 2009-03-10 Irreversibly closable flow control clamp and fluid processing set

Publications (1)

Publication Number Publication Date
US20050215975A1 true US20050215975A1 (en) 2005-09-29

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ID=27663267

Family Applications (6)

Application Number Title Priority Date Filing Date
US10/501,571 Abandoned US20050215975A1 (en) 2002-01-31 2003-01-21 Irreversibly closable flow control clamp
US12/401,332 Expired - Lifetime US8517970B2 (en) 2002-01-31 2009-03-10 Irreversibly closable flow control clamp and fluid processing set
US13/196,668 Expired - Lifetime US8956339B2 (en) 2002-01-31 2011-08-02 Irreversibly closable flow control clamp
US14/601,416 Expired - Lifetime US9498616B2 (en) 2002-01-31 2015-01-21 Irreversibly closable flow control clamp
US15/297,484 Expired - Lifetime US9789301B2 (en) 2002-01-31 2016-10-19 Irreversibly closable flow control clamp
US15/693,597 Expired - Lifetime US10335586B2 (en) 2002-01-31 2017-09-01 Irreversibly closable flow control clamp

Family Applications After (5)

Application Number Title Priority Date Filing Date
US12/401,332 Expired - Lifetime US8517970B2 (en) 2002-01-31 2009-03-10 Irreversibly closable flow control clamp and fluid processing set
US13/196,668 Expired - Lifetime US8956339B2 (en) 2002-01-31 2011-08-02 Irreversibly closable flow control clamp
US14/601,416 Expired - Lifetime US9498616B2 (en) 2002-01-31 2015-01-21 Irreversibly closable flow control clamp
US15/297,484 Expired - Lifetime US9789301B2 (en) 2002-01-31 2016-10-19 Irreversibly closable flow control clamp
US15/693,597 Expired - Lifetime US10335586B2 (en) 2002-01-31 2017-09-01 Irreversibly closable flow control clamp

Country Status (5)

Country Link
US (6) US20050215975A1 (de)
EP (2) EP1469904B1 (de)
AT (1) ATE480293T1 (de)
DE (1) DE60334067D1 (de)
WO (1) WO2003063945A1 (de)

Cited By (11)

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EP2047883A1 (de) 2007-10-09 2009-04-15 Fenwal, Inc. Flüssigkeitsdurchflussregler
US20100268161A1 (en) * 2007-09-04 2010-10-21 Fresenius Vial Sas Clamp for a flexible tube, pump provided with means for opening such a clamp, and infusion kit provided with such a clamp
US20110186521A1 (en) * 2003-01-07 2011-08-04 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US8262639B2 (en) 2002-01-31 2012-09-11 Fenwal, Inc. Irreversible flow control clamp
WO2015064233A1 (ja) * 2013-10-29 2015-05-07 ニプロ株式会社 クランプ
US9833606B2 (en) 2012-09-07 2017-12-05 Fenwal, Inc. Non-reopenable flow control clamp
US10130746B2 (en) 2003-01-07 2018-11-20 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US10189728B2 (en) 2011-12-13 2019-01-29 Nxstage Medical, Inc. Fluid purification methods, devices, and systems
US10973969B2 (en) 2005-01-07 2021-04-13 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US11040186B2 (en) * 2015-10-28 2021-06-22 Becton, Dickinson And Company Pinch clamp device
US11628290B2 (en) 2016-02-17 2023-04-18 Becton, Dickinson And Company Pinch clamp

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EP1469904B1 (de) 2002-01-31 2010-09-08 Fenwal, Inc. Irreversibel schliessbare stromregelklemme
WO2007112500A1 (en) * 2006-04-05 2007-10-11 Noble House Group Pty. Ltd. Non-reopening locking pinch clamp for tubing
JP3134511U (ja) * 2007-06-05 2007-08-16 川澄化学工業株式会社 クランプ及び医療用具
EP2332611B1 (de) * 2009-12-10 2020-06-17 Fenwal, Inc. Irreversibel schliessbare Durchflussregelungsklemme für flexible Schläuche
DE102010017216A1 (de) * 2010-06-02 2011-12-08 Technische Universität Berlin Ventilvorrichtung zum Steuern eines Flusses eines Fluides durch einen Fluidkanal, Anordnung sowie Mehrwegventilvorrichtung
US10143357B2 (en) * 2010-08-10 2018-12-04 Ronald Yamada Endoscope gripping device
EP2676690B1 (de) * 2011-02-17 2021-07-28 Nipro Corporation Medizinische schlauchklemme
JP5908898B2 (ja) * 2011-05-16 2016-04-26 テルモ株式会社 クランプおよび血液バッグシステム
US9829113B2 (en) 2012-05-25 2017-11-28 Nxstage Medical, Inc. Clamp device and methods for making and using
WO2014078237A1 (en) * 2012-11-16 2014-05-22 Eaves Felmont F Fixation device for securing a linear element to a workpiece
US8905978B2 (en) * 2013-03-14 2014-12-09 Haemonetics Corporation Non-reopening tubing clamp and method of use thereof
US9717888B2 (en) * 2015-01-26 2017-08-01 Thomas A. Sos Guidewire clamp and introducer
CN107206227B (zh) 2015-02-03 2021-06-01 日机装株式会社 夹持装置
US10328189B2 (en) 2016-04-21 2019-06-25 Fenwal, Inc. Methods and systems for reducing the risk of bacterial contamination in collected platelets
WO2018237277A1 (en) 2017-06-22 2018-12-27 Teleflex Medical Incorporated SURGICAL FORCEPS
EP4393416A2 (de) 2017-11-14 2024-07-03 Teleflex Medical Incorporated Chirurgische klammer
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US11446417B2 (en) 2003-01-07 2022-09-20 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
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US8545428B2 (en) * 2003-01-07 2013-10-01 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US8679348B2 (en) 2003-01-07 2014-03-25 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US10130746B2 (en) 2003-01-07 2018-11-20 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US10973969B2 (en) 2005-01-07 2021-04-13 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US11896750B2 (en) 2005-01-07 2024-02-13 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
US20100268161A1 (en) * 2007-09-04 2010-10-21 Fresenius Vial Sas Clamp for a flexible tube, pump provided with means for opening such a clamp, and infusion kit provided with such a clamp
US9162044B2 (en) 2007-09-04 2015-10-20 Fresenius Vial Sas Clamp for a flexible tube, pump equipped with means for opening such a clamp, and perfusion set equipped with such a clamp
US8328763B2 (en) 2007-09-04 2012-12-11 Fresenius Vial Sas Clamp for a flexible tube, pump provided with means for opening such a clamp, and infusion kit provided with such a clamp
EP2047883A1 (de) 2007-10-09 2009-04-15 Fenwal, Inc. Flüssigkeitsdurchflussregler
US10189728B2 (en) 2011-12-13 2019-01-29 Nxstage Medical, Inc. Fluid purification methods, devices, and systems
US10189727B2 (en) 2011-12-13 2019-01-29 Nxstage Medical, Inc. Fluid purification methods, devices, and systems
US10947135B2 (en) 2011-12-13 2021-03-16 Nxstage Medical, Inc. Fluid purification methods, devices, and systems
US9833606B2 (en) 2012-09-07 2017-12-05 Fenwal, Inc. Non-reopenable flow control clamp
WO2015064233A1 (ja) * 2013-10-29 2015-05-07 ニプロ株式会社 クランプ
JPWO2015064233A1 (ja) * 2013-10-29 2017-03-09 ニプロ株式会社 クランプ
US11040186B2 (en) * 2015-10-28 2021-06-22 Becton, Dickinson And Company Pinch clamp device
US11724088B2 (en) 2015-10-28 2023-08-15 Becton, Dickinson And Company Pinch clamp device
US11628290B2 (en) 2016-02-17 2023-04-18 Becton, Dickinson And Company Pinch clamp
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WO2003063945A1 (en) 2003-08-07
EP1469904B1 (de) 2010-09-08
EP1469904A4 (de) 2005-05-11
EP2357016B1 (de) 2016-04-20
US20120172755A1 (en) 2012-07-05
US8517970B2 (en) 2013-08-27
DE60334067D1 (de) 2010-10-21
US20090306619A1 (en) 2009-12-10
ATE480293T1 (de) 2010-09-15
US8956339B2 (en) 2015-02-17
US10335586B2 (en) 2019-07-02
EP2357016A1 (de) 2011-08-17
US9789301B2 (en) 2017-10-17
US9498616B2 (en) 2016-11-22
EP1469904A1 (de) 2004-10-27
US20170361086A1 (en) 2017-12-21
US20170100578A1 (en) 2017-04-13

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