US20050159676A1 - Targeted biopsy delivery system - Google Patents

Targeted biopsy delivery system Download PDF

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Publication number
US20050159676A1
US20050159676A1 US10/842,652 US84265204A US2005159676A1 US 20050159676 A1 US20050159676 A1 US 20050159676A1 US 84265204 A US84265204 A US 84265204A US 2005159676 A1 US2005159676 A1 US 2005159676A1
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Prior art keywords
biopsy
biopsy needle
redirecting
needle
cannula
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Abandoned
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US10/842,652
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English (en)
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James Taylor
Bruce Olson
Stephen Lewis
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Individual
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Individual
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Priority to US10/842,652 priority Critical patent/US20050159676A1/en
Priority to AT05744025T priority patent/ATE505136T1/de
Priority to CN200580020326XA priority patent/CN101132736B/zh
Priority to JP2007513204A priority patent/JP4837658B2/ja
Priority to ES05744025T priority patent/ES2365476T3/es
Priority to CA2566231A priority patent/CA2566231C/en
Priority to PCT/US2005/015431 priority patent/WO2005110255A2/en
Priority to AU2005244164A priority patent/AU2005244164B2/en
Priority to EP05744025A priority patent/EP1765178B1/en
Priority to DE602005027462T priority patent/DE602005027462D1/de
Priority to KR1020067025865A priority patent/KR20070028402A/ko
Publication of US20050159676A1 publication Critical patent/US20050159676A1/en
Priority to US11/895,228 priority patent/US7833168B2/en
Priority to US12/214,163 priority patent/US20090054807A1/en
Priority to HK08107340.4A priority patent/HK1117014A1/xx
Priority to US12/968,870 priority patent/US8317724B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
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Definitions

  • Prostate health is a significant concern for men over the age of fifty. If prostate cancer is suspected from either a physical examination or because of a Prostate Specific Antigens test, a biopsy is performed to collect tissue samples from the prostate for evaluation by a pathologist. Prostate tumors are small growths scattered about the prostate. For this reason, a physician will take multiple tissue samples from different areas of the prostate, typically between 9 and 18 samples.
  • TRUS Transrectal Ultrasound
  • An end-fire ultrasound probe is used, which generates a pie-shaped image plane.
  • Some end-fire probes are manufactured with a biopsy needle channel, which passes through the body of the probe at an angle, such that a biopsy needle set inserted through the biopsy needle channel exits the channel at a slight angle relative to the body of the probe.
  • Most probes require a needle set guide tube to be affixed to the probe body, such that a needle set placed through the guide tube parallels the axis of the probe and the needle set can be extended beyond the end of the probe.
  • the physician inserts the ultrasound probe into the rectum, and moves the probe around until the specific area of the prostate to be sampled is identified. The physician then bends the probe upward, pointing the biopsy needle channel or biopsy needle set guide at the targeted area of the prostate. A needle set is inserted into and through the needle channel or guide, pushed through the rectum wall and into the prostate.
  • Standard coring biopsy needles sets are made from substantially rigid, coaxially aligned, stainless steel wire and tubing. They are comprised of two basic components; an inner solid wire stylet with specimen notch and a hollow outer cutting cannula.
  • Batten, et al (U.S. Pat. No. 5,398,690) discloses a slaved biopsy device, analysis apparatus, and process. In Batten, an ultrasound device is inserted into the male urinary tract through the penis, with the biopsy and treatment device inserted transrectally.
  • Chin, et al (U.S. Pat. No. 6,179,249) discloses an ultrasound guided therapeutic and diagnostic device. Chin is a flexible ultrasound device used for laproscopic surgery. Lin (U.S. Pat. No. 6,261,234) disclosed a method and apparatus for ultrasound imaging with biplane instrument guidance.
  • Lin's ultrasound device uses two transducers to create two image planes, and has a biopsy needle guide which directs a biopsy needle at the intersection of the imaging planes.
  • Burney, et al U.S. Pat. No. 6,447,477) discloses surgical and pharmaceutical site access guide and methods. Burney shows a biopsy device in which a thick needle with side exit ports is inserted into the targeted tissue. Biopsy needles are then inserted into the thick needle, exiting out the side to take samples. Further, a number of systems have specified the use of flexible biopsy needle kits.
  • a biopsy system to allow a biopsy to be planned prior to the tissue sampling, to allow the biopsy needle to be precisely inserted into a targeted area and which is able to record the precise location from which the tissue sample is collected while the imaging device remains stationary. Users would also benefit from a flexible needle set which may be easily “fired” while in a curved position. Further, users would benefit from a means of precisely delivering a treatment to a targeted area of an organ or tissue mass.
  • Another object of the invention is to allow a biopsy plan to be formulated identifying the specific quadrants and areas of the prostate to be sampled.
  • Another object of the invention is to allow this biopsy plan to be saved as a reference point.
  • Another object of the invention is to allow a physician to adjust the biopsy needle guide to allow the physician to precisely insert the needle into the tissue at the planned location.
  • Another object of the invention is to allow a physician to monitor the needle set as it is inserted into the tissue, to verify that the needle is in the planned location.
  • Another object of the invention is to provide a biopsy needle guide which can be affixed to or associated with existing side-imaging transrectal ultrasound probes.
  • a further object of the invention is to allow the transrectal ultrasound probe to remain stationary while the biopsy samples are gathered from different areas of the prostate, thereby improving the accuracy of the procedure.
  • a further object of the invention is to allow the probe to remain stationary while the needle guide is moved longitudinally along the probe and is also rotated around the probe.
  • a further object of the invention is to provide a needle set guide which can redirect the needle set such that the needle set can be curved while still maintaining the freedom of movement to allow the firing and collecting of tissue samples.
  • a further object of the invention is to provide a biopsy needle set that may be redirected at an angle and further maintains its ability to be fired and so collect the tissue samples.
  • An object of an alternative embodiment of the invention is to allow a treatment plan to be formulated identifying the specific areas of tissue or an organ to be treated.
  • a further object of an alternative embodiment of the invention is to allow this treatment plan to be saved as a reference point.
  • Another object of an alternative embodiment of the invention is to allow a physician to precisely insert a needle or treatment delivery means into the tissue at the planned location.
  • Another object of the invention is to allow a physician to monitor the needle or treatment delivery method as it is inserted into the tissue, to verify that the needle or treatment delivery method is in the planned location.
  • the present invention relates to a biopsy targeting system for use with ultrasound imaging devices, and particularly for use in sampling prostate tissue.
  • the biopsy targeting system consists of a redirecting biopsy needle guide which works in conjunction with a side-view or end-fire transrectal ultrasound probe, a cooperating software program which can be loaded and operated on a computer controlled ultrasound system, and a bendable needle set.
  • the transrectal ultrasound probe is placed in the cradle of a stabilizer.
  • the redirecting needle guide positioning assembly is also affixed to the cradle.
  • the physician advances and adjusts the cradle to allow the transrectal probe to be inserted into the rectum of a patient.
  • the physician generates an ultrasound image while positioning the probe to insure that the patient's prostate is viewable within the viewing area of the probe. Once the probe is correctly positioned, the physician then locks the probe in place in the stabilizer.
  • the physician initiates a full 3D scan of the prostate.
  • the multiple image slices are captured by the ultrasound system.
  • the physician looks through these saved images, to identify possible problem areas of the prostate and further to decide which areas of the prostate to sample.
  • physicians collect 9 to 18 tissue samples from different areas of the prostate.
  • the physician is able to use the software program to project potential needle path lines onto the images of the prostate. These paths are shown as lines in views parallel to the needle path and as circles where the paths pierce the image plane. Each possible path is described by the positional settings of the redirecting needle guide.
  • the physician moves a projected needle path line to intersect the planed area to be biopsied.
  • the physician continues to evaluate the prostate and target additional areas for sampling, again saving projected needle paths for each planned sample. Further, if the physician does not identify any possible problem areas, but wishes to take a standard biopsy, the physician can use a range of default setting on the computer program to project between 9 and 18 projected needle paths with a standard distribution throughout the prostate.
  • the physician initiates the biopsy. All of the needle paths for a given longitudinal image are displayed on the ultrasound monitor. The display shows the coordinates of the planned needle paths which correlate to the positional setting of the redirecting needle guide. The physician then advances and/or rotates the redirecting needle guide to the correlating coordinates for the first planned needle path. The physician then inserts a flexible biopsy needle kit into the redirecting needle guide's needle insertion point. The needle set is advanced by hand through the needle set channel, including through the redirecting curve within the needle guide. This redirecting curve causes the needle to exit the needle guide, within the rectum of the patient, at an angle relative to the transrectal probe.
  • the physician pushes the needle guide through the tissue of the rectal wall and into the prostate, monitoring the progress of the needle on the ultrasound system and insuring that the actual path of the needle matches the planned needle path being projected on the image.
  • the physician uses a standard biopsy firing gun to “fire” the needle set, causing the stylet and cannula to quickly extend in sequence, cutting and capturing a slice of prostate tissue in the specimen notch of the needle set. Because the specimen notch is substantially longer than in standard biopsy needles and the cannula body is flexible, the needle set is very flexible and able to be fired even though bent.
  • the specimen notch is extended to the curved portion of the needle set within the redirecting needle set guide, allowing the stylet to be quickly moved in reference to the cannula without binding.
  • the physician saves the ultrasound image(s) on the computer program, creating a permanent record of the biopsy tissue location.
  • the physician then removes the biopsy needle with captured tissue sample. Once removed, the cannula is retracted from the stylet, allowing the tissue sample to be placed into a tissue specimen dish.
  • the physician then advances or moves the redirecting biopsy needle guide to the next planned needle path location, and repeats the procedure.
  • FIG. 1 is a perspective view of targetable biopsy system in conjunction with an ultrasound imaging system and stabilizer.
  • FIG. 2 is a perspective view of the redirecting needle set guide mounted on a side-imaging transrectal ultrasound probe.
  • FIG. 3 is a side view of the redirecting needle set guide mounted on a side-imaging transrectal ultrasound probe, showing the guide positioning assembly.
  • FIG. 4 is a planning software interface displayed on the monitor.
  • FIG. 5 is a schematic of the biopsy planning process.
  • FIG. 6 is a schematic of the biopsy procedure.
  • FIG. 7 is a side view of an embodiment of the targetable biopsy guide.
  • FIG. 8 is a side cutaway view of an embodiment of the targetable biopsy guide designed to be manufactured with an insertable metal tube.
  • FIG. 9 is a side cutaway view of an alternative embodiment of the targetable biopsy guide.
  • FIG. 10 is a side cutaway view of an alternative embodiment of the targetable biopsy guide with an enlarged bend channel.
  • FIG. 11 shows a side view of a biopsy stylet with extended specimen notch.
  • FIG. 12 shows a side view of an alternative embodiment of the stylet with dual extended specimen notches.
  • FIG. 13 shows a side view of an alternative embodiment of the stylet with a tiered specimen notch.
  • FIG. 14 shows a side view of an alternative embodiment of the stylet with multiple notches to facilitate bending.
  • FIG. 15 shows a side view of an embodiment of the cannula in which the cannula tube has been ground down along its length to leave a flexible spine.
  • FIG. 16 shows a side view of an embodiment of the cannula in which the cannula tube has been spiral-cut along its length to facilitate bending of the cannula.
  • FIG. 17 shows a side view of an alternative embodiment of the cannula in which the tip of the cannula tube is uncut while the body of the cannula tube has been spiral-cut.
  • FIG. 18 shows a side view of an alternative embodiment of the cannula in which sections of the cannula tube alternate between cut and uncut.
  • FIG. 19 shows a side view of an embodiment of the cannula in which the cannula tube is encased in flexible tubing.
  • FIG. 20 shows a perspective view of an embodiment of the flexible needle set.
  • FIG. 21 is a side view of the traditional method of taking a prostate biopsy with a biopsy needle channel.
  • FIG. 22 is a side view of the bendable needle and biopsy targeting system mounted on a side-fired probe taking a biopsy.
  • FIG. 23 is a side view of the redirecting guide with a flexible needle set inserted and extending out of the guide such that the needle set is bent by the needle set channel bend.
  • the targeted biopsy system is comprised of a redirecting guide 10 , positioning assembly 11 , targeting software system 12 (loaded on CPU 18 ) and flexible needle set 13 (best seen in FIG. 20 ).
  • the positioning assembly 11 is affixed to cradle 15 , which is a part of stepper and stabilizer 16 .
  • ultrasound system 17 which is comprised of ultrasound system CPU 18 , side view transrectal probe 19 and monitor 20 .
  • Side view transrectal probe is comprised of probe tip 22 and probe imaging window 23 . As seen in FIGS.
  • the redirecting guide 10 consists of guide body 30 , needle set channel 31 , needle set insertion point 32 , and needle set exit point 33 , front body guide extensions 34 A and 34 B, imaging cutout 35 .
  • needle set channel 31 may be provided with enlarged bend channel 37 .
  • the redirecting guide 10 may be provided with insertable metal tube 38 .
  • the redirecting guide may contain one or more pathways may be used for insertion of the biopsy needle kit.
  • the redirecting guide may be comprised of a movable device such that the opening through which the needle kit exits may be moved relative to the opening into which the biopsy needle kit is placed.
  • the redirecting guide may straighten a previously curved biopsy needle kit such that the biopsy needle kit re-curve when leaving the redirecting guide.
  • positioning assembly 11 is comprised of rotational adjustment collar 40 , fixed collar 41 , longitudinal slides 42 and longitudinal position controller 43 .
  • targeting software system 12 is comprised of transverse image display 212 , Sagittal Image display 213 , longitudinal projected needle path 51 and transverse projected needle path 52 , in addition to various controls.
  • flexible needle set 13 consists of flexible stylet 60 and flexible cannula 61 .
  • Stylet 60 may be affixed to stylet hub 76 , with cannula 61 affixed to cannula hub 77 .
  • cannula 61 may be provided with depth markings 79 .
  • the preferred Flexible stylet 60 consists of tip 62 , extended specimen notch 63 and stylet body 64 .
  • an alternative preferred Flexible stylet 60 consists of tip 62 and segmented specimen notches 72 a and 72 b .
  • Alternative embodiments of flexible stylet 60 as seen in FIGS. 13 and 14 , contain bending notches 70 and tiered specimen notch 71 .
  • cannula 61 consists of cutting tip 65 , cannula body 66 and cannula sheath 81 .
  • the cannula sheath may have beveled edges.
  • a portion of the body of flexible cannula 61 has been removed.
  • cannula body 66 may be provided with spiral cut 82 to facilitate bending.
  • cannula body 66 may be provided with non-spiral cut portion 83 at cutting tip 65 , to facilitate the straight entry of the cannula into the tissue.
  • FIG. 16 cannula body 66 may be provided with non-spiral cut portion 83 at cutting tip 65 , to facilitate the straight entry of the cannula into the tissue.
  • cannula body 66 may be provided with non-spiral cut portions 83 interspersed with spiral cuts 82 .
  • flexible cannula 61 consists of a cutting tip inserted into the flexible cannula body.
  • both the stylet cannula can be made from a range of flexible materials, including combinations of one or more materials, to facilitate the bendability. This may include traditional materials used in medical devices, such as stainless steel, as well as materials such an nitinol®.
  • the cannula design may mirror the stylet, such that portion or portions of the metal cannula tube are removed to create a metal component which has a metal cutting tip, a long spine consisting of only a portion of the cannula wall in the flexible part of the cannula and then the full tubular cannula.
  • the machine cannula may be partially or wholly incased in a cannula sheath, which may be plastic or some other material.
  • FIG. 21 shows a biopsy being performed using the standard method, using an end-fire ultrasound probe with a biopsy needle channel.
  • the probe is inserted into the rectum, and then angled upward until the probe tip is pointed at the desired portion of the prostate.
  • a needle set is then inserted through the biopsy needle channel guide into the prostate 2 .
  • side view transrectal probe 19 is mounted on the cradle 15 of a stabilizer 16 .
  • Redirecting guide 10 is also mounted on the cradle 15 , such that guide body 30 sits atop probe tip 22 .
  • front body extensions 34 a and 34 b partially wrap around probe tip 22 to help maintain the guide body 30 on the probe tip 22 .
  • the cradle 15 is moved forward, with the probe tip 22 inserted into patient's rectum 1 .
  • Probe tip 22 is generating ultrasound images, which are displayed on monitor 20 . The physician uses this image to insure that the entirety of prostate 2 is viewable by probe imaging window 23 . Once the probe tip 22 is correctly positioned, the physician locks in place cradle 15 .
  • the biopsy planning process is illustrated in FIG. 5 .
  • a representative display of the biopsy information to the user is shown in FIG. 4 .
  • the process begins with the planning software obtaining a set of volumetric data 101 .
  • the volumetric data consists of two sets of sampled images. One set is of longitudinal images sampled at a regular angular spacing, and the other is a set of transverse images sampled at regular depth spacing. If only one of the two sets is available, one may be interpolated from the other.
  • the physician starts the planning process by pressing button 203 to satisfy step 102 of FIG. 4 .
  • the planning system overlays a series of lines 51 a, b, c , etc. and dots 52 a, b, c , etc.
  • a record is placed into needle path coordinates display window 204 showing the coordinates of the path.
  • the user may also remove a specific path from the plan by selecting button 207 .
  • the physician or technician may then proceed with the biopsy procedure, to complete the series of precision located biopsy's to be taken through the usage of this instrument. For example, as can be noted in FIG. 6 , once a biopsy procedure has been completed, the physician then determines whether any more biopsies are needed, and where the biopsy locations may be determined. This can be seen at 301 . If no additional biopsies are required, this is the end of the procedure. If additional biopsies are considered as needed, the physician then adjusts the redirection of the guide 10 , and the longitudinal controller 40 , to mass the desired biopsy coordinates, as provided upon the scanner. This can be noted at 302 .
  • the user inserts a needle set 13 into the channel 32 , to prepare for additional biopsies.
  • the physician then inserts the needle into the patient, moving the needle in and out to adjust for depth, as determined by the scanner, as can be seen at 304 .
  • the physician can determine if the needle tip is at the correct depth, at 305 . If it is not, then the physician may move the needle and adjust its depth further. If it is, the physician then fires the needle of the biopsy instrument, as at 306 .
  • the physician removes the needle set 13 from the patient, having taken the biopsy as required.
  • the tissue sample is removed from the biopsy needle notch, for further analysis by the lab. This can be noted at 308 . When this is completed, this concludes the conduct of biopsies upon the patient.
  • preplanned biopsy selection menu 209 allows the user to select a pre-determined needle pattern, typically 9-12 needle paths, without having to select each needle path manually.
  • the needle paths generated could need to be adjusted for the specific size of the organ.
  • the size of the organ can be input by various means.
  • the planning process allows the physician to modify the needle paths as needed and to approve that they are correct.
  • Projected needle paths 51 a , 51 b , etc, include needle path location registry 50 , which indicate the horizontal and rotational position of the needle path in reference to the probe.
  • the physician rotates redirecting guide 10 using rotational adjustment collar 40 , and then advances the redirecting guide using longitudinal position controller 40 , both of which have position information which correlates to the needle path location registry 50 .
  • the physician inserts flexible needle set 13 into needle set insertion point 32 and into needle set channel 31 .
  • the needle set 13 is redirected at an angle away from the axis of probe tip 22 . Needle set 13 exits needle set exit point 33 .
  • the physician is able to see the needle set in the ultrasound image as it exits exit point 33 , allowing the physician to insure that the needle set 13 is in the path marked by projected needle path 51 a .
  • the physician monitors the depth of the needle set 13 as it is pushed through the rectum wall and into the prostate 2 . Once the desired depth is reached, the physician stops inserting the needle set 13 .
  • the needle set 13 is “fired”. This causes flexible stylet 60 to rapidly advance a short distance, such that tissue from the prostate two prolapses into extended specimen notch 63 .
  • FIG. 23 provides a side cut-away view of the redirecting guide with a flexible needle set inserted and extending out of the guide such that the extended specimen notch is bent by the needle set channel bend.
  • the invention is used to plan and perform a targeted treatment of an organ or tissue mass.
  • the process begins with the planning software obtaining a set of volumetric data.
  • the planning system overlays a series of needle path lines and needle path dots on the images in panes 212 and 213 , which represent the available needle paths with coordinates that match the coordinates on rotational adjustment collar 40 and longitudinal position controller 43 of positioning assembly 11 .
  • the user selects specific needle paths, which are saved the treatment plan. Preplanned treatment selections allow the user to select a pre-determined needle pattern without having to select each needle path manually.
  • the physician rotates redirecting guide using rotational adjustment collar, and then advances the redirecting guide using longitudinal position controller, both of which have position information which correlates to the needle path location registry.
  • the physician then inserts a flexible needle set or treatment delivery means into needle set insertion point 32 and into needle set channel 31 .
  • the needle set or treatment delivery means reaches the needle set channel bend, the needle set or treatment delivery method is redirected at an angle away from the axis of probe tip 22 . Needle set 13 exits needle set exit point 33 . Because of imaging cutout 35 , the physician is able to see the needle set or treatment delivery method in the ultrasound image as it exits exit point 33 .
  • the physician monitors the depth of the needle set or treatment delivery method as it is pushed into the targeted organ or tissue mass. Once the desired depth is reached, the physician is able to undertake the preferred activity. This may include using the delivery means to inject a solid, gas or liquid material or other treatment apparatus into the targeted organ or tissue mass. Further, the physician may insert an organism into the targeted organ or tissue mass. The material may be deposited and left in the targeted organ or tissue mass. Further, material previously deposited may be removed. The use of the deposited material may be as a treatment, a marker, or other uses. Further, the delivery means may be used to apply energy to a targeted organ or tissue mass, including but not limited to heat, cold, light and radiation.
  • the physician then removes the flexible needle set or treatment delivery method, and then resets the redirecting guide to the coordinates of the next saved projected needle path.
  • the physician has the option of saving the image of the treatment needle in the targeted organ or tissue mass, to record the location of the treatment as delivered. The process is repeated until the physician has treated or marked all of the targeted areas of the organ or tissue mass.

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  • Ultra Sonic Daignosis Equipment (AREA)
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US10/842,652 2003-08-13 2004-05-10 Targeted biopsy delivery system Abandoned US20050159676A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US10/842,652 US20050159676A1 (en) 2003-08-13 2004-05-10 Targeted biopsy delivery system
AU2005244164A AU2005244164B2 (en) 2004-05-10 2005-05-04 Targeted biopsy delivery system
EP05744025A EP1765178B1 (en) 2004-05-10 2005-05-04 Targeted biopsy delivery system
JP2007513204A JP4837658B2 (ja) 2004-05-10 2005-05-04 標的生検搬送システム
ES05744025T ES2365476T3 (es) 2004-05-10 2005-05-04 Sistema para realizar una biopsia dirigida.
CA2566231A CA2566231C (en) 2004-05-10 2005-05-04 Targeted biopsy delivery system
PCT/US2005/015431 WO2005110255A2 (en) 2004-05-10 2005-05-04 Targeted biopsy delivery system
AT05744025T ATE505136T1 (de) 2004-05-10 2005-05-04 Gezieltes biopsie-abgabesystem
CN200580020326XA CN101132736B (zh) 2004-05-10 2005-05-04 目标活组织检查传送系统
DE602005027462T DE602005027462D1 (de) 2004-05-10 2005-05-04 Gezieltes biopsie-abgabesystem
KR1020067025865A KR20070028402A (ko) 2004-05-10 2005-05-04 목표 생검용 이송 시스템
US11/895,228 US7833168B2 (en) 2003-08-13 2007-08-23 Targeted biopsy delivery system
US12/214,163 US20090054807A1 (en) 2003-08-13 2008-06-17 Targeted biopsy delivery system
HK08107340.4A HK1117014A1 (en) 2004-05-10 2008-07-03 Targeted biopsy delivery system
US12/968,870 US8317724B2 (en) 2003-08-13 2010-12-15 Targeted treatment delivery system

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US49491003P 2003-08-13 2003-08-13
US10/842,652 US20050159676A1 (en) 2003-08-13 2004-05-10 Targeted biopsy delivery system

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US11/895,228 Expired - Lifetime US7833168B2 (en) 2003-08-13 2007-08-23 Targeted biopsy delivery system
US12/214,163 Abandoned US20090054807A1 (en) 2003-08-13 2008-06-17 Targeted biopsy delivery system
US12/968,870 Active 2024-06-09 US8317724B2 (en) 2003-08-13 2010-12-15 Targeted treatment delivery system

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US12/214,163 Abandoned US20090054807A1 (en) 2003-08-13 2008-06-17 Targeted biopsy delivery system
US12/968,870 Active 2024-06-09 US8317724B2 (en) 2003-08-13 2010-12-15 Targeted treatment delivery system

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US (4) US20050159676A1 (ja)
EP (1) EP1765178B1 (ja)
JP (1) JP4837658B2 (ja)
KR (1) KR20070028402A (ja)
CN (1) CN101132736B (ja)
AT (1) ATE505136T1 (ja)
AU (1) AU2005244164B2 (ja)
CA (1) CA2566231C (ja)
DE (1) DE602005027462D1 (ja)
ES (1) ES2365476T3 (ja)
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ATE505136T1 (de) 2011-04-15
EP1765178A4 (en) 2009-04-08
EP1765178A2 (en) 2007-03-28
WO2005110255A3 (en) 2007-02-15
CA2566231C (en) 2013-12-31
DE602005027462D1 (de) 2011-05-26
US20110144492A1 (en) 2011-06-16
CN101132736B (zh) 2011-06-15
JP2007536063A (ja) 2007-12-13
KR20070028402A (ko) 2007-03-12
JP4837658B2 (ja) 2011-12-14
HK1117014A1 (en) 2009-01-09
EP1765178B1 (en) 2011-04-13
US7833168B2 (en) 2010-11-16
AU2005244164B2 (en) 2011-02-03
ES2365476T3 (es) 2011-10-06
WO2005110255A2 (en) 2005-11-24
AU2005244164A1 (en) 2005-11-24
US20070293787A1 (en) 2007-12-20
CN101132736A (zh) 2008-02-27
US20090054807A1 (en) 2009-02-26
US8317724B2 (en) 2012-11-27
CA2566231A1 (en) 2005-11-24

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