US20050159646A1 - Optical probe accessory device for use in in vivo diagnostic procedures - Google Patents

Optical probe accessory device for use in in vivo diagnostic procedures Download PDF

Info

Publication number
US20050159646A1
US20050159646A1 US11/018,665 US1866504A US2005159646A1 US 20050159646 A1 US20050159646 A1 US 20050159646A1 US 1866504 A US1866504 A US 1866504A US 2005159646 A1 US2005159646 A1 US 2005159646A1
Authority
US
United States
Prior art keywords
accessory device
probe
optical
optical probe
device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/018,665
Inventor
Robert Nordstrom
David Bee
Mark Modell
Ze'ev Hed
Jennie Kwo
Matthew Emans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MediSpectra Inc
Original Assignee
MediSpectra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US08/782,936 priority Critical patent/US6104945A/en
Priority to US11537399P priority
Priority to US09/241,806 priority patent/US6411835B1/en
Priority to US13823599P priority
Priority to US09/481,762 priority patent/US6826422B1/en
Priority to US09/591,706 priority patent/US6847490B1/en
Application filed by MediSpectra Inc filed Critical MediSpectra Inc
Priority to US11/018,665 priority patent/US20050159646A1/en
Assigned to MEDISPECTRA, INC. reassignment MEDISPECTRA, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEE, DAVID, MODELL, MARK, NORDSTROM, ROBERT, HED, ZE'EV, PRODUCT GENESIS, INC.
Assigned to PRODUCT GENESIS, INC. reassignment PRODUCT GENESIS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EMANS, MATTHEW, KWO, JENNIE
Publication of US20050159646A1 publication Critical patent/US20050159646A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002Operational features of endoscopes
    • A61B1/00062Operational features of endoscopes provided with means for preventing overuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • A61B1/00103Constructional details of the endoscope body designed for single use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00131Accessories for endoscopes
    • A61B1/00135Oversleeves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00142Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with means for preventing contamination, e.g. by using a sanitary sheath
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002Operational features of endoscopes
    • A61B1/00059Operational features of endoscopes provided with identification means for the endoscope
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • A61B1/00071Insertion part of the endoscope body
    • A61B1/0008Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00082Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • A61B1/00071Insertion part of the endoscope body
    • A61B1/0008Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096Optical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08Accessories or related features not otherwise provided for
    • A61B2090/0814Preventing re-use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08Sensors provided with means for identification, e.g. barcodes or memory chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy

Abstract

The present invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access luminal spaces within the body of a patient without sacrificing the quality of optical data obtained. The accessory device further comprises either, singly, or in combination, selectable features or options which optimize light transmission, maximize patient comfort, and provide single-use capabilities.

Description

    RELATED APPLICATIONS
  • The application claims priority to U.S. Provisional Application Ser. No. 60/138,235, filed on Jun. 9, 1999 and is also a continuation-in part of U.S. patent application Ser. No. 09/481,762, filed Jan. 11, 2000, which claims priority to U.S. Provisional Application Ser. No. 60/115,373, filed Jan. 11, 1999, and is a continuation-in-part of U.S. patent application Ser. No. 09/241,806, filed Feb. 2, 1999, which is a continuation-in-part of U.S. patent application Ser. No. 08/782,936, filed Jan. 13, 1997. The entirety of these applications is incorporated by reference.
  • FIELD OF THE INVENTION
  • The invention relates to an accessory device for an optical probe for use in in vivo diagnostic procedures. The accessory device provides an optimal optical path for light from an optical probe while minimizing patient discomfort. The accessory device features optional selectable elements to enhance its versatility in in vivo diagnostic procedures.
  • BACKGROUND OF THE INVENTION
  • The early detection of disease increases the chance for successful therapeutic intervention. Non-invasive optical diagnostic devices which detect changes in the biochemical and structural features of tissues provide tools to detect the early stages of disease (e.g., cancer). An optical device for detecting tissue features typically comprises a console unit which includes a light source, a detector, electronics, and a computer, in communication with an optical probe through which light is transmitted to and from a tissue. The optical probe can be the end of a fiber optic cable or can contain complex optical elements intended to shape an output light beam from an optical source into a desired geometry.
  • Optical probes coupled to endoscopic devices have been used to obtain tissue-specific information from patients. Representative organs which can be characterized using an endoscopic approach include the colon, uterus, bladder, and stomach. Fluorescence spectroscopy using endoscopic optical probes can distinguish between cancerous and precancerous tissue in these organs. However, the development of optical probes for clinical use has been hampered due to the difficulty of miniaturizing the optical elements necessary for the collection of optical data. Additional constraints arise because an optical probe, like any medical access device, must be decontaminated and sterilized prior to reuse. The delicate construction of light directing and focussing elements within the optical probe generally make it difficult, if not impossible, to sterilize the probe.
  • Because it is generally not economical to discard an optical probe after a single use, it is desirable to provide an accessory device which acts as a shield between the illumination optics of the optical probe and the tissue being analyzed. While it is generally known in the art to equip a medical device with a protective barrier or sheath to provide a cover for the device, it is desirable to provide an accessory device for an optical probe which serves more than a mere barrier function, but which complements the function of the optical probe. Accordingly, the present invention provides an accessory device for an optical probe which comprises multiple optional features to enhance the versatility of the device in in vivo diagnostic procedures.
  • SUMMARY OF THE INVENTION
  • The invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which accesses luminal spaces within the body of a patient without sacrificing the quality of optical data obtained. The accessory device further comprises either, singly, or in combination, selectable features which optimize light transmission, maximize patient comfort, and provide single-use capabilities.
  • In one aspect of the invention, an accessory device for an optical probe is provided which creates an optimal light path between the optical probe and a target tissue. Optional optical elements are provided which enhance the light transmitting and light receiving functions of the probe. In one embodiment, an accessory device comprises optical elements which create an optical waveguide to improve optical data collection by the probe. In this embodiment, the accessory device includes a window which functions as an objective for the optical probe's illumination elements. In other embodiments of the invention, the window is coated with anti-fog and/or anti-glare agents to maximize the passage of diagnostic light to and from the probe. In still other embodiments, the accessory device is adapted to function with an optical probe which comprises a plurality of optical fibers and the accessory device comprises a plurality of openings sized to accept a plurality of light transmitting fibers from the optical probe.
  • By acting as an intermediate between the optical probe and the target tissue being analyzed, the accessory device is not subject to the same design constraints as the optical probe (i.e., does not have to be a certain minimum size to accommodate a plurality of optical elements). Accordingly, in one aspect of the invention, the accessory device can be tailored to conform to a particular body lumen being accessed (e.g., in one embodiment, the cervix, in another embodiment, an ear canal).
  • For example, an optical probe accessory device which comprises, at least in portion, a flexible material which conforms to the shape of a body space being accessed is contemplated by the present invention. The flexible portion provides a shield between the tissue being assayed by the optical probe and the probe itself. In another embodiment, a segment of the flexible portion conforms to an end of the optical probe bearing illumination optics, protecting the illumination optics of the probe from bodily fluids while shielding the patient from contaminants. In still another embodiment, the flexible nature of the accessory device allows it to be rolled up before and after use with the probe.
  • In another aspect of the invention, the attachment device is a single-use, disposable device, allowing the optical probe to be used multiple times without transmitting disease from one patient to another. In this embodiment, to maximize the attachment device's capacity to protect patients from contamination, the attachment device is crippled, either mechanically, or electronically, after a single use, so that an optical probe will not function with an attachment device which has been previously used.
  • For example, the accessory device comprises a body and an attachment element and is mechanically prevented from re-use. In this embodiment, the attachment element attaches the accessory device to the probe and detaches from the body of the accessory device when the accessory device is removed from the probe. The accessory device is unable to function without the attachment element and so detachment of the accessory device from the probe prevents its reuse. In one embodiment, the attachment element comprises a grasping element, such as a tab or a snap ring which detaches the attachment element from the body of the accessory device. In a further embodiment, the attachment element is separated from the body of the accessory device by perforations and rupturing the perforations detaches the attachment element from the body of the accessory device.
  • In yet another embodiment, a disposable, single-use accessory device for an optical probe comprises an electrical element rather than a mechanical element which prevents its re-use in another patient. In one embodiment, the accessory device comprises an electrical element bearing encoded information (e.g., identification information). In another embodiment, the electrical element is remotely programmable and the information contained within the electrical element can be altered by the user.
  • In a further aspect of the present invention, a system is provided which comprises a processor and an electrical element reader. The electrical element reader accesses information encoded in the electrical element carried by the accessory device and transmits a signal to the processor relating to identification information carried by the electrical element. The processor includes a memory which stores identification information and which compares the stored information with identification information encoded by the electrical element. The processor transmits instructions based on whether or not a match is found between identification information encoded in the electrical element and identification information stored within the memory. If no match is found, the identification information encoded in the electrical element is added to the memory.
  • The instructions transmitted by the processor control the actuation of the optical probe. For example, in one embodiment, the system includes a light source in communication with both the processor and the optical probe. Transmission of light from the light source to the probe relies upon instructions received from the processor. In another embodiment, instructions from the processor can include particular operating parameters relating to a tissue-specific diagnostic procedure (for example, but not limited to the diagnosis of cervical cancer). Use of an accessory device with an electrical element which identifies the device as one which is suited for accessing the cervix triggers the processor to implement operating parameters suited to the diagnosis of cervical cancer. Thus, the system provides flexibility that allows the optical probe to be used with a variety of accessory devices in a variety of diagnostic procedures.
  • Any or all of the foregoing optional features (the optical features to enhance light transmission, minimally invasive, tissue-conforming structural features, mechanical or electrical disabling elements conferring single-use capabilities) can be combined to meet the needs of a particular diagnostic procedure. Because of the modular nature of the optical probe accessory device, the optical probe itself is not limited for use in a single diagnostic application but can be adapted for a variety of diagnostic applications.
  • The foregoing and other objects, aspects, features, and advantages of the invention will become apparent from the following description and from the claims.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The objects and features of the invention can be better understood with reference to the following detailed description and accompanying drawings, in which like reference characters generally refer to the same parts throughout the different views.
  • FIG. 1 shows a schematic representation of an accessory device for an optical probe according to one embodiment comprising an optical window located at an end of the device distal from the illumination optics of an optical probe.
  • FIGS. 2A and 2B show a schematic representation of an accessory device according to one embodiment comprising a single side-looking window. FIG. 2A shows a side view of such a device. FIG. 2B shows a top view.
  • FIG. 3 shows a schematic representation of a single use accessory probe according to one embodiment comprising a sectional transparent window.
  • FIG. 4 shows a schematic representation of a single-use accessory device according to one embodiment comprising a flexible tear-away sheath.
  • FIG. 5 shows a single-use accessory device according to one embodiment of the invention comprising an electrical element for encoding identification information.
  • FIGS. 6A-C show schematic representations of accessory devices for optical probes marked with identifying information in the form of a bar code. FIG. 6A shows an accessory device comprising a bar code on the side of the device. FIGS. 6B and C show an embodiment of the invention in which the bar code is placed on an optical window which forms the end of the device distal to the illumination optics of the optical probe. FIG. 6A shows a view of the end of the device bearing the bar code. FIG. 6C shows a view of the side of the device.
  • DETAILED DESCRIPTION
  • Because an accessory device according to the invention complements the function of an optical probe such accessory devices provide more than merely a sheath for an optical probe. An accessory device of the invention comprises a number of optional features which a user can select in optimizing the accessory device to suit a particular application. Any or all of these options can be present in an accessory device according to the invention. Because of the many permutations of accessory devices which can be designed according to the invention, the optical probe itself acquires more versatility and can be used in a variety of diagnostic settings. It will be apparent to those of skill in the art after reading this disclosure that other options can additionally be provided, and such options are encompassed within the scope of the invention. All that is required to practice the present invention, is that the accessory device permit optical data collection by an optical probe without obstruction. A number of preferred features of a device of the invention is discussed below. These may be used singly or in combination with each other or with other probe features known in the art. The skilled artisan appreciates that numerous other features may be included in a device of the invention, either alone or in combination.
  • Option 1. Maximal Light Transmission
  • In one aspect of the invention, the accessory device provides additional optical features to enhance the transmission of light from the optical probe to the tissue and from the tissue to the optical probe. According to this aspect of the invention, the user selects optical features that are for the accessory device that are compatible with the operation parameters of the optical probe.
  • In practice, the accessory device is fabricated using material which has a high optical transmission over the spectral bandwidth of operation of the probe. For example, for some probes, obtaining an image by the probe is not as important as obtaining a very high signal-to-noise ratio from an optical response in spectral regions that do not overlap, or only partially overlap, the visible region of the spectrum. That is, the inclusion of features to ensure adequate performance of the optics to create a visual image of the sample may degrade the performance of the device in collecting acceptable optical signals such as fluorescence, Raman, or reflectance spectra. In embodiments where image quality is not an issue, the portion of the accessory device actually transmitting an ultraviolet (UV) excitation beam (e.g., the end of the device distal to the probe) can be made of a very thin Teflon® or can comprise other fluoroplastics such as THV-200P® (a TFE/HPF/VDF terfluoropolymer from the 3M® corporation). These plastics do not demonstrate a significant fluorescent response when irradiated with UV.
  • In some embodiments, the accessory device is used with an optical probe which functions by directing light to a tissue and receiving at least fluorescent light re-emitted from the tissue after absorption of the excitation light, while in other embodiments, the accessory device receives scattered light from a target tissue, such as elastic scattered light (e.g. reflectance spectroscopy) or inelastic scattered light (e.g., as in Raman spectroscopy applications). In these embodiments, the light being directed back to the probe provides diagnostic information relating to the chemical/structural features of a tissue being analyzed rather than its morphological features. An accessory device used in these applications is made of materials which provide minimal interference with the light being directed back towards the probe. In a preferred embodiment, the accessory device comprises a low-fluorescing plastic and has high optical transmission through the ultraviolet and visible spectral regions from 300 nm to 750 nm.
  • In other embodiments, where imaging is a function of the probe, an accessory device is provided which does not fluoresce when illuminated by a laser or other light source and has a sufficiently large aperture or opening to collect low levels of light emitted during fluorescence of some samples such as tissue, good modulation transfer function for good image transmission, and/or a lack of color tint to preserve spectral accuracy. The accessory device can be fabricated from material including, but not limited to, UVT acrylic or amorphous polyolefin (e.g., Zeonex®, Nippon Zeon CO., Ltd.) and the like. The skilled artisan can recognize and identify equivalent materials using routine experimentation and routine testing.
  • The type of optical probe, and hence the type of accessory device used, will depend upon the particular diagnostic application required. For example, in diagnosing cervical tissue pathologies, in some instances it is desirable to obtain both imaging and non-imaging optical information. This combination of modalities is important when spatial location of biopsy sites is the output of the optical device. In this embodiment, an accessory device should be selected which creates minimal interference with the spectroscopic functions of the device, and has good imaging capability to locate specific tissue sites. However, when the application is ASCUS Triage (Atypical Squamous Cells of Undetermined Significance Triage), non-imaging information is more important, because determining the location of the abnormal tissue is not necessary. Here, an accessory device can be used which is not suited for imaging purposes. In a third instance, the optical probe can be used as an adjunct to a standard pap smear test. In this embodiment, a non-imaging device is suitable.
  • The present invention also contemplates that the optical features of the accessory device include optical elements which complement the function of the optical probe. In one embodiment, the accessory device includes a flat window which permits passage of diagnostic light to and from the optical probe without distortion. Window materials include, but are not limited to, cast or molded polymethylmetacrylate (PMMA) and other materials which provide no significant fluorescence in response to an excitation beam. By way on non-limiting examples, polystyrene or polycarbonate are two such materials. The placement of the window on the accessory device is selected to optimize the collection of light from a tissue being analyzed. In one embodiment, shown in FIG. 1, the window 11 is at the end of the accessory body 10 most distal from the probe. In another preferred embodiment, shown in FIGS. 2A-B and FIG. 3, the window is provided on the side of the accessory device, giving the opportunity to gather optical information from the side as the device is moved along or through a sample. The window can be configured in a variety of shapes. In the embodiment shown in FIGS. 2A and 2, the accessory device comprises a circular window 13. In the embodiment shown in FIG. 3, the window is a transparent section 15 of the accessory device.
  • In another preferred device, the window is fastened onto the end of a cylindrical- or toroidal-shaped ring segment that is press-fitted onto the accessory device, forming an annular lens which functions as an objective for the optical probe's illumination elements. The wall thickness of the ring segment on which the window/lens sits is designed to allow the accessory device to act as an optical waveguide to direct light onto target tissues for better visualization or data collection. In one embodiment of the invention, the wall thickness of the ring segment is between about 0.5 mm and 2.0 mm. The window itself can form a lens, or alternatively, a lens can be added to the window as a separate element. For example, the window can be segmented so that a portion of the structure is flat (i.e., optically passive), while other portions are curved (i.e., forming lens segments).
  • In another accessory device contemplated by the invention, a delivery apparatus is operably connected to the window for dispensing a fluid which has an index of refraction matching the window or other exposed optical elements in the accessory device and/or optical probe. Delivery devices encompassed within the scope of the invention include a bead or other container residing in a space defined by the ring segment which can be caused to break and discharge its fluid. Fluid from the delivery device spreads downward by capillary force to fill the space between optical elements in the accessory device (e.g., such as the window itself) and the optical probe. In another embodiment, the window is coated with an anti-fog agent or an anti-glare agent. In still a further embodiment, the accessory device is provided with a flexible sleeve which covers the window and serves a protective function.
  • The accessory device of the present invention can also be adapted to include other optical elements to facilitate the acquisition of diagnostic data, such as filters, polarizers, or light reflecting elements. For example, in one embodiment of the invention, the distal end of the accessory device includes a reflecting element such as an integral faceted mirror. In a further embodiment, the reflecting element is in the shape of a cone which has a half angle of 45 degrees. A light beam impinging on one of the facets of the reflecting element will be reflected at a 90 degree angle to the incident light causing it to be emitted laterally from the distal end of the accessory device, allowing light to be efficiently directed to the target tissue within the lumen the accessory device is accessing. A light-focusing element can additionally be provided in optical communication with the reflecting element in order to focus light beams appropriately on the target tissue. In still further embodiments of the invention, reflecting elements are provided within the body of the accessory device in optical communication with a window. In the embodiment of the invention shown in FIG. 2B, the reflective element is a reflective planar surface 14. In the embodiment of the invention shown in FIG. 3, the reflecting element is a conical surface which directs light from the optical probe towards the transparent sectional window 15. It should be apparent to those a skill in the art that a variety of shapes of reflecting surfaces can be provided and positioned to optimize the light path from the optical probe to the window of the accessory device.
  • In embodiments of the invention where the optical probe being used with the accessory device comprises a plurality of optical fibers, a reflecting element can be provided whose number of facets correspond to the number of excitation fibers in the probe, creating an optimal light path between the target tissue and light from the optical probe through the accessory device. In this embodiment, the accessory device can also be configured to attach to the probe in way that further optimizes this light path. For example, in one preferred embodiment, the accessory device is fitted onto the probe via a connecting ring which comprises openings designed to adapt to a particular configuration of optical fibers (e.g., bundled or spaced). Attachment of the probe to the accessory device can only be achieved by correctly aligning optical fibers with appropriate regions in the accessory device. In one instance, the optical probe comprises a plurality of pins which fit into holes in the connecting ring of the accessory device only when the accessory device is positioned in a specific orientation, ensuring the proper orientation of the optical probe with respect to the accessory device.
  • Additionally, the accessory device can be adapted to provide a light source for evenly illuminating a tissue being visualized. In one embodiment, the accessory device includes an illuminating light source positioned around the circumference of the accessory device. The illuminating light source can be an integral part of the device or can be snapped on by a ring mechanism.
  • In applications where visible marking or tagging specific regions of the sample is necessary or important, the accessory device is provided with a dispenser capable of directing a marking fluid toward the sample. The fluid can be applied to localized regions of the sample for identifying selected regions, or it can be dispensed over a broad region of the sample, as a bath or wash. The purpose of the bath or wash may be to affect chemical changes in the sample to aid in the identification of substances in or characteristics of the sample. For example, in optical detection of pre-cancerous lesions of the cervix, the application of a mild acetic acid wash increases the contrast and visibility of the regions of suspicious lesions.
  • Other types of fluids that can be used to enhance visualization of the sample, include hypertonic, hypotonic, hyperosmotic, and hypo-osmotic solutions. Hyper- or hypo-osmotic solutions can be generated in a number of ways, such as by using distilled water, either alone, or in combination with ionic or nonionic molecular constituents. Varying the hydrogen ion concentration of a fluid (e.g., pH) can generate additional visualization-enhancing agents. Dye solutions can also be applied such as, for example, Lugol's iodine, toluidine blue or methylene blue, and others.
  • Option 2. Minimal Invasiveness, Tissue-Conforming Structure
  • The accessory device can be designed to conform to a particular lumen being accessed, thus minimizing the invasive effect of the accessory device. In one embodiment, the accessory device comprises a flexible portion which provides a shield between the tissue being assayed and the optical probe while at the same time maximizing patient comfort by adapting itself to any space being accessed by the device. In one embodiment, the flexible accessory device can be in the form of an inflatable balloon into which a fluid (e.g., an index-matching fluid) is inserted to partially inflate the structure. Balloons can be made from compliant materials, such as polyethylene, latex (natural or synthetic), polyurethane, and silicone, or non-compliant materials, such as polyethylene terephthalate (PET).
  • When brought into contact with the tissue, the flexible accessory device distributes the contact pressure of the device evenly over the entire contact surface (such as a body lumen), while the index-matching fluid provides good optical communication with the tissue. In another embodiment, the flexible portion also conforms to the end of the optical probe bearing illumination optics, shielding the illumination optics of the probe from body fluids, while simultaneously shielding the patient from contamination by the probe. In this embodiment of the invention, the accessory device comprises, at least in portion, a shrink-fitted material (e.g., which can be shrunk using heat). A heating element (such as, but not limited to, a resister) can be included in the shrink-fitted material such that shrinkage is triggered when a voltage is applied to the resistor. Alternatively, the material can be shrunk using a heating device such as a hand-held hairdryer. Because of the flexible nature of the accessory device, it can be packaged in a rolled-up state (e.g., in a sterile wrapper) to be unrolled over the optical probe when it is ready to be used.
  • In one embodiment, the accessory device comprises both a flexible portion and a rigid tip portion. The length and diameter of the tip portion is selected to be optimal for accessing a particular body lumen and to provide for the effective transmission of diagnostic light from the optical probe, while the flexible portion of the accessory device is conformed like a skirt and is proximal to the end of the optical probe bearing illumination optics. The flared and flexible nature of the flexible portion minimizes patient discomfort from the entry of any portion of the optical probe itself into the body cavity being accessed. The flexible material and the rigid portion of the accessory device can be molded as a single unit or can be molded separately and connected together.
  • The optical probe accessory device according to the present invention can also be designed for a particular anatomic application, e.g., for obtaining information relating to tissue features of the gastrointestinal tract, the urinary tract, the peritoneal cavity, the thorax, ear canal, and the female reproductive tract. Other organs suitable for endoscopic or percutaneous access will be apparent to those of ordinary skill in the art. In each of these cases, the accessory device is designed as a probe with a particular geometry adapted for the body region towards which it is directed. In one embodiment of the invention, an accessory device is provided for use with an optical probe used in the cervix. In this embodiment, the accessory device covers the sides of the probe that encounters the vaginal walls and additionally covers the end of the optical probe comprising illumination optics. In a further embodiment, the accessory device is designed to at least partially cover an optical probe and is capable of passing, with the probe, through a distal aperture of an endoscope. In this embodiment, the accessory device is accordingly limited in sized to conform to the dimensions of the body cavity being accessed and the dimensions of the endoscope.
  • In still other embodiments of the invention, the accessory device is designed to transmit light from an optical probe to the surface of a tissue which is not accessed through a lumen, for example, the skin, or breast tissue, or tissue within an open surgical field.
  • Option 3. Single-Use Device
  • In accordance with the present invention, a single-use accessory device is provided for at least partially covering an optical probe. In one embodiment, the accessory device entirely covers the probe, while in another embodiment, the accessory device covers or shield those parts of the probe adapted for contact with a body tissue of a patient. As defined herein, the term “single-use” is understood to mean that the use of the accessory device is restricted to use with a single patient. However, in some embodiments, use can be confined to a single diagnostic measurement.
  • In one preferred embodiment according to this aspect of the invention, the accessory device comprises both a body and an attachment element for attaching the accessory device to the probe wherein the device is mechanically prevented from re-use. For example, the accessory device comprises a breakable element to allow for physical breakage of at least a portion of the device upon removal from the optical probe. The attachment element according to this embodiment includes at least one breakable portion which must be broken in order to remove the accessory device from the probe. Breaking the breakable portion cripples the accessory device, preventing its reattachment and re-use. In another embodiment, the breakable portion includes a grasping element, such as a tab or snap ring, and grasping the grasping element results in breaking the body of the accessory device from the attachment element. In still another embodiment, as shown in FIG. 4, the attachment element comprises a flexible material 12 and the accessory device can only be detached from the probe by tearing the flexible material 12, separating the attachment element portion of the accessory device from the body portion. Alternatively, the flexible element can comprise a weakened material, or breakpoint, where it joins to the body of the device (e.g., perforations) to facilitate tearing. The breakpoint is more susceptible to mechanical stress than the remaining portions of the device.
  • The attachment element can be mechanically attached to optical probe by a variety of mechanisms, including, but not limited, to a tab/slot mechanism (such as a tab on the attachment element fits into a slot on the outside of the optical probe or visa versa), a magnetic attachment means, a lock and pin mechanism, a band-latching mechanism, or a string. Other types of attachment mechanisms (such as fasteners, elastic bands, strings within the accessory device which can hook onto the probe, Velcro, adhesive, tapes, glues), including those which rely on mating a protruding element (on the accessory device or the probe) to a recessed element (on the probe or the accessory device) will doubtless be apparent to those of skill in the art, and are included within the scope of the invention.
  • In another embodiment, the actual means of attachment of the attachment element is the breakable element in the device. For example, in one embodiment, where the attachment element attaches to the probe by a tab/slot mechanism, removal of the accessory device can only be performed by breaking the tab off, thereby preventing the accessory device from being reattached. In another embodiment, where a protruding mating element is provided on the accessory device to allow it to mate with a recessed element in the optical probe, the protruding mating element is designed to tear along a tear line, or perforation, in the accessory device upon mechanical stress (e.g., when the protruding element on the attachment element is disengaged from recessed element on the surface of the optical probe), preventing the protruding mating element from functioning in future.
  • In yet another embodiment of the invention, at least the attachment element of the device is made of a flexible material and a “cinch purse” string is provided to both secure the attachment element to the device and to provide a grasping element. In this embodiment, the string is attached to a breakable element so that pulling the string breaks the breakable element and permits the flexible portion of the accessory device to be rolled over, away from the optical probe. Once the breakable element is broken, the accessory device is unable to be reattached to the optical probe.
  • While the attachment element can attach directly to the optical probe, it can also attach through an intermediate interfacing element which itself attaches to the probe (e.g., via a ring or a plastic connecting sleeve). In a further embodiment of the invention, the attachment element and the body of the accessory device are modules which can be fitted together. Different types of interfacing elements can be used to interface different types of attachment elements and bodies to different optical probes, allowing the user to select and combine different desired features of the accessory device with a particular kind of optical probe.
  • In another embodiment of the single-use option, the accessory device is prevented from reuse by degrading the optical quality of the accessory device after use. For example, coatings susceptible to ultraviolet radiation, can be placed on the light-transmitting portion of the accessory device. During proper use of the device, the coating is subjected to a sufficient quantity of ultraviolet radiation so that it becomes at least partially opaque, preventing its reuse.
  • The invention also provides an accessory device which can be disabled after use without physically altering the device, that is, electronically, for example. In one embodiment, an electrical contact between the accessory and the optical probe is provided. In this embodiment, an electrical element is embedded within the accessory device which is capable of making electrical contact with the optical probe when the accessory device is properly affixed to the probe. As defined herein, the term “electrical element” encompasses both passive electrical elements (e.g., resistors, capacitors, inductors, diodes, and others) and active electrical elements (e.g., transistors, integrated circuits, such as microchips, and others). In one embodiment, after use, the optical probe delivers a current to the accessory device sufficient to destroy the electrical element, thus preventing reuse of the accessory device.
  • In another embodiment, as shown in FIG. 5, the accessory device is provided with an electrical element 17 bearing encoded information. The electrical element can be secured to the accessory device by insertion at a notch on the surface of the device, or alternatively, can be held in place by a biocompatible adhesive (e.g., a cyanoacrylic adhesive) and can additionally include electrical contact elements for making contact with the probe.
  • In one embodiment of the invention, the electrical element 17 bears encoded information relating to the identification of the accessory device. For example, the encoded information identifies the device as one which has already been used with the optical probe. In a further embodiment, the electrical element 17 includes encoded information relating a target tissue which is being analyzed. Additional information encoded by the electrical element 17 includes, but is not limited to, time, present date, date of manufacture, materials used in construction, and the condition of the optical probe or the processing system used with the optical probe. Additionally, the electrical element 17 can include information regarding the intended use of the optical probe, and can enable only certain modes of operation of the probe. As defined herein, an “operating mode” refers to either, or both, the input or output of the optical probe. In one embodiment, the operating mode is a functioning or non-functioning state of the optical probe. In another embodiment, the operating mode is any of a plurality of input or output states of the device. For example, in one operating mode, the optical probe is directed to provide optical information relating to the location of a sample (e.g., a cancerous tissue) while in another operating mode, the optical probe is directed to provide information relating only to a biochemical feature of a sample (e.g., the presence or absence of fluorescence relating to a cancerous or precancerous state), while in still another operating mode, both types of information are provided.
  • Different types of electrical elements can be used. The electrical element can be a programmable read-only memory chip (PROM). The electrical element can be remotely programmable. In another embodiment of the invention, the electrical element is an RFID (radiofrequency identification device) or another active seminconductor device.
  • Information within the electrical element can be passed on to a processor in communication with the optical probe through a electrical element reader which accesses stored information in the electrical element in a non-contacting manner. In one embodiment, the electrical element reader is capable of receiving electromagnetic signals. In another embodiment, the electrical element reader is capable of receiving radiosignals from the electrical element.
  • When the electrical element reader is placed in a location in which it can access stored identification information encoded in the electrical element, the electrical element reader transfers this information to a processor to which the optical probe is operatively connected. For example, the electrical element reader can be either attachable to the optical probe or an integral part of the optical probe itself, such that the reader has access to the electrical element as soon as the accessory device is attached to the optical probe. Information from the electrical element is thus immediately transferred to the processor which provides instructions to the probe to either enable it or prevent it from functioning. In one embodiment, where the electrical element is an RFID chip, the “reader” is a transponder for receiving radiosignals from the electrical element.
  • In some applications, it is desirable to re-use the accessory device if another diagnostic test needs to be done with the same patient within a short time of the first diagnostic test (e.g., where the probe has not been removed from the patient). In this embodiment, the electrical element can be re-programmed or programmed with additional information, allowing the optical probe to function with the same accessory device. In certain embodiments of the invention, the electrical element reader is configured as an encoding device to conveniently change or add information stored within the electrical element.
  • As contemplated herein, processor includes a memory which comprises identification information identifying accessory devices that have been used with the optical probe. If a match is found between the identification information obtained by the electrical element reader and the identification information within the memory, the processor transmits instructions to the optical probe which prevents it from functioning. The instructions are then relayed to component(s) of an optical diagnostic system of which the optical probe is a part. For example, the optical diagnostic system comprises a light source which is in optical communication with the optical probe. The presence of a match between identification information encoded by the electrical element and identification information within the memory of the processor prevents light from being transmitted from the light source to the optical probe. In another embodiment of the invention, the optical diagnostic system comprises an optical probe-locking device which prevents the probe from being moved (e.g., to position it within a patient) if a match is found thus effectively preventing the probe from being used with the “wrong” accessory device. When no match is found between the information stored within the electrical element and information stored within the memory, the identification information relating to the electrical element is added to the memory. In this way, subsequent use of the accessory device will result in instructions being sent to the probe which prevents it from operating.
  • In an alternative embodiment, the processor can transmit instructions to the optical probe which allow it to function if a “correct” accessory device is used with the probe. In this embodiment, the processor transmits instructions to either the probe itself and/or to other components of the optical diagnostic system when no match is found between identification information encoded in the electrical element and the identification information stored in the memory. The instructions then trigger the optical probe or other component of the optical diagnostic system to function (for example, light can be transmitted through the optical probe or a specific diagnostic application can be run in response to the instructions).
  • In another embodiment, the electrical element is encoded with identification information which can only be read if the accessory device is positioned in a correct orientation with respect to the optical probe (for example, in an orientation which maximizes light transmission from the probe to the accessory device). In this embodiment, the processor will only transmit instructions to the optical probe to allow the probe to function if the accessory device is positioned correctly.
  • Information other than identifying information can also be transmitted to the processor via the electrical element. For example, information relating to the “readiness” of the optical probe/accessory device can be provided to the electrical element by sensors on the accessory device or the optical probe which are responsive to the environment in which the accessory device/and or probe is placed. The electrical element in turn transmits the information to the processor which can alter the functioning of the probe as appropriate.
  • The electrical element can further include information relating to the target tissue being analyzed. In this embodiment of the invention, information read by the electrical element reader triggers the processor to activate diagnostic programs unique to the analysis of that particular tissue. For example, the accessory device comprises a electrical element identifying it as an accessory device used to access the cervix. When the processor receives this information from the electrical element reader, the processor will access specific computer program product(s) (e.g., software applications) relating to the diagnosis of cervical tissue pathologies (e.g., cervical cancer) and will activate particular data input or data display screens that relate to diagnosing these pathologies. In other embodiments, the electrical element can include patient identifying information, including information relating to a history of a particular disease (e.g., whether the patient has a family history of cervical cancer).
  • In certain embodiments, a particular type of accessory device is preferred for a particular diagnostic application. In these embodiments, it is desirable to prevent an optical diagnostic system from functioning unless it is used with a suitable accessory device. In order to ensure that the proper accessory device is used in its appropriate diagnostic application, the electrical element in the accessory device is encoded with information indicating that it is suited for a particular use(s). When the processor accesses this information through the electrical element reader, only a proper match between the use and the device will permit the optical probe or other components of the optical system to function.
  • Although, non-physical means of crippling the accessory device after a single use have been disclosed with reference to an electrical element, it should be apparent to those of skill in the art that a number of different types of feedback mechanisms can be incorporated into an optical diagnostic system. In one embodiment, an optical probe is provided which is equipped with a light emitting diode and an infrared sensor, while the accessory device is marked with a series of lines on one of its surfaces providing identification information. In this embodiment, the optical probe sensor obtains information relating to the accessory device's identification information and transfers this information to the processor which sends instructions to the probe or other components of the system to enable or prevent the probe from functioning with that particular accessory device.
  • Optical methods for communicating the usage history of the accessory device to the optical probe can also include bar codes. In one embodiment as shown in FIG. 6A, a bar code 18 designed to be read by reflectance or fluorescence is fixed to the body of the accessory device. If it is placed on the side of the accessory device, a separate reader may be needed to scan the code. The lot number, intended use, and other pertinent information is contained in the code and interpreted by the optical scanner. In another embodiment, shown in FIG. 6B, the code 19 is fixed to a transparent part 20 of the accessory device. This permits the optical system itself to read the contents of the code 19 prior to performing its measurement of the sample (e.g., tissue). Other accessory device marker and reader combinations will be apparent to those of skill in the art, and are encompassed within the scope of the invention.
  • As discussed above, any or all of the foregoing options can be combined to create accessory devices suitable for particular diagnostic purposes. For example, an accessory device including optical elements can also include electrical and/or mechanical elements to disable the devise so that it can only be used a single time. Devices with optical elements and/or single-use devices can include the structural features that make an accessory device minimally invasive and/or tissue-conforming. Any and all of these combinations are encompassed within the scope of the invention.
  • Variations, modifications, and other implementations of what is described herein will occur to those of ordinary skill in the art without departing from the spirit and scope of the invention as claimed. Accordingly, the invention is to be defined not by the preceding illustrative description but instead by the spirit and scope of the following claims.

Claims (30)

1. An accessory device for an optical probe comprising a body and an attachment element for attaching the accessory device to the probe, said attachment element detaching from the body of the accessory device when the accessory device is removed from the probe, thereby preventing re-use of the accessory device.
2. The accessory device of claim 1, wherein said attachment element includes a grasping element and wherein grasping said grasping element detaches said attachment element from the body of the accessory device.
3. The accessory device of claim 2, wherein the grasping element is a tab or snap ring.
4. The accessory device of claim 1, wherein the attachment element is conformable to an end of the probe bearing illumination optics.
5. The accessory device of claim 4, wherein the attachment element is flexible and the body of the accessory device is rigid.
6. The accessory device of claim 1, wherein the attachment element is separated from the body of the accessory device by perforations and wherein rupturing said perforations detaches the attachment element from the body of the accessory device.
7. The accessory device of claim 1, wherein at least a portion of the device is made of a shrink-fitted material.
8. The accessory device of claim 7, wherein the shrink-fitted material is shrinkable using heat.
9. The accessory device of claim 7, wherein the accessory device can be rolled up before and after use with an optical probe.
10-41. (canceled)
42. The accessory device of claim 1, wherein the attachment element is configured to prevent reattachment of the accessory device to the probe after the accessory device is removed from the probe.
43. An accessory device for an optical diagnostic system having an associated reader, the accessory device comprising a marker capable of being read by the reader to thereby prevent re-use of the accessory device.
44. The accessory device of claim 43, wherein the marker comprises a bar code.
45. The accessory device of claim 43, wherein the marker comprises an RFID chip.
46. The accessory device of claim 43, wherein the marker is capable of being read by an optical sensor.
47. The accessory device of claim 43, wherein the marker comprises encoded information.
48. The accessory device of claim 47, wherein the encoded information comprises identification information.
49. The accessory device of claim 43, wherein at least a portion of the accessory device provides a shield between a contact surface and an optical probe.
50. The accessory device of claim 49, wherein the optical probe is a part of the optical diagnostic system.
51. The accessory device of claim 49, wherein the accessory device is configured to prevent contact between a patient and the optical probe.
52. The accessory device of claim 49, wherein the contact surface is a body lumen and wherein at least a portion of the accessory device is configured to conform to the body lumen.
53. A method for limiting re-use of an accessory device with an optical probe in an optical diagnostic system, the method comprising the steps of:
providing an accessory device comprising a marker;
reading the marker to obtain information about the accessory device; and at least one of:
disabling operation of the optical probe with the accessory device based at least in part on the information, where the accessory device has been previously used; and
enabling operation of the optical probe with the accessory device based at least in part on the information, where the accessory device has not been previously used.
54. The method of claim 53, wherein at least a portion of the accessory device provides a shield between a contact surface and the optical probe.
55. The method of claim 54, wherein the contact surface is a body lumen and wherein at least a portion of the accessory device conforms to the body lumen.
56. The method of claim 53, wherein the information comprises identification information about the accessory device.
57. The method of claim 53, wherein the information comprises usage history of the accessory device.
58. The method of claim 53, wherein the marker comprises a bar code.
59. The method of claim 53, wherein the marker comprises an RFID chip.
60. The method of claim 53, wherein the reading step comprises scanning the marker.
61. The method of claim 53, wherein the method prevents re-use of the accessory device with the optical probe.
US11/018,665 1995-08-01 2004-12-21 Optical probe accessory device for use in in vivo diagnostic procedures Abandoned US20050159646A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US08/782,936 US6104945A (en) 1995-08-01 1997-01-13 Spectral volume microprobe arrays
US11537399P true 1999-01-11 1999-01-11
US09/241,806 US6411835B1 (en) 1997-01-13 1999-02-02 Spectral volume microprobe arrays
US13823599P true 1999-06-09 1999-06-09
US09/481,762 US6826422B1 (en) 1997-01-13 2000-01-11 Spectral volume microprobe arrays
US09/591,706 US6847490B1 (en) 1997-01-13 2000-06-09 Optical probe accessory device for use in vivo diagnostic procedures
US11/018,665 US20050159646A1 (en) 1997-01-13 2004-12-21 Optical probe accessory device for use in in vivo diagnostic procedures

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/018,665 US20050159646A1 (en) 1997-01-13 2004-12-21 Optical probe accessory device for use in in vivo diagnostic procedures

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US09/241,806 Continuation-In-Part US6411835B1 (en) 1995-08-01 1999-02-02 Spectral volume microprobe arrays
US09/481,762 Continuation-In-Part US6826422B1 (en) 1995-08-01 2000-01-11 Spectral volume microprobe arrays
US09/591,706 Division US6847490B1 (en) 1995-08-01 2000-06-09 Optical probe accessory device for use in vivo diagnostic procedures

Publications (1)

Publication Number Publication Date
US20050159646A1 true US20050159646A1 (en) 2005-07-21

Family

ID=34069421

Family Applications (2)

Application Number Title Priority Date Filing Date
US09/591,706 Expired - Fee Related US6847490B1 (en) 1995-08-01 2000-06-09 Optical probe accessory device for use in vivo diagnostic procedures
US11/018,665 Abandoned US20050159646A1 (en) 1995-08-01 2004-12-21 Optical probe accessory device for use in in vivo diagnostic procedures

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09/591,706 Expired - Fee Related US6847490B1 (en) 1995-08-01 2000-06-09 Optical probe accessory device for use in vivo diagnostic procedures

Country Status (1)

Country Link
US (2) US6847490B1 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050288594A1 (en) * 2002-11-29 2005-12-29 Shlomo Lewkowicz Methods, device and system for in vivo diagnosis
US20070112253A1 (en) * 2005-11-15 2007-05-17 Pentax Corporation Endoscope light source unit
WO2007138552A3 (en) * 2006-05-30 2008-03-06 Joachim Kahlert Apparatus for depth-resolved measurements of properties of tissue
US20080294002A1 (en) * 2006-08-22 2008-11-27 Olympus Corporation Endoscope apparatus and endoscope probe
US20090118581A1 (en) * 1999-11-15 2009-05-07 Gavriel Meron Method for activating an image collecting process
US20090259220A1 (en) * 2008-04-09 2009-10-15 Angiodynamics, Inc. Treatment Devices and Methods
US20090284588A1 (en) * 2007-02-05 2009-11-19 Olympus Corporation Endoscope apparatus
US20100300922A1 (en) * 2009-05-27 2010-12-02 Zvika Gilad System and method for storing and activating an in vivo imaging capsule
US7907643B2 (en) 2002-07-25 2011-03-15 Angiodynamics, Inc. Laser system
US20110098576A1 (en) * 2009-12-01 2011-04-28 Hollstien David S Non-invasive implant rupture detection system
US8068890B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Pulse oximetry sensor switchover
EP2462859A1 (en) * 2010-12-09 2012-06-13 IFM-Gerbershagen GmbH Protective sleeve for a laparoscope
US8862194B2 (en) 2008-06-30 2014-10-14 Covidien Lp Method for improved oxygen saturation estimation in the presence of noise
WO2014144307A3 (en) * 2013-03-15 2015-01-29 Oncoscope, Inc. Probe assembly and disposable cover particularly for use in endoscope applications of low coherence interferometry
EP2910177A1 (en) * 2014-02-19 2015-08-26 Everest Display Inc. Gastrointestinal tract diagnosis device with disposable endoscope and control method for the same
US9161694B2 (en) 2005-01-24 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US10080576B2 (en) 2013-03-08 2018-09-25 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
US10130427B2 (en) 2010-09-17 2018-11-20 Auris Health, Inc. Systems and methods for positioning an elongate member inside a body
US10149720B2 (en) 2013-03-08 2018-12-11 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
WO2019091695A1 (en) * 2017-11-10 2019-05-16 Böllhoff Verbindungstechnik GmbH Sanitary protective cap
US10363103B2 (en) 2009-04-29 2019-07-30 Auris Health, Inc. Flexible and steerable elongate instruments with shape control and support elements
US10376672B2 (en) 2013-03-15 2019-08-13 Auris Health, Inc. Catheter insertion system and method of fabrication

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6847490B1 (en) * 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US6427082B1 (en) * 1998-12-23 2002-07-30 Medispectra, Incorporated Optical methods and systems for rapid screening of the cervix
JP2002533142A (en) * 1998-12-23 2002-10-08 メディスペクトラ, インコーポレイテッド System and method for optical testing of samples
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US8068897B1 (en) 1999-03-01 2011-11-29 Gazdzinski Robert F Endoscopic smart probe and method
US20120071710A1 (en) 1999-03-01 2012-03-22 Gazdzinski Robert F Endoscopic smart probe and method
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US8065155B1 (en) 1999-06-10 2011-11-22 Gazdzinski Robert F Adaptive advertising apparatus and methods
US7260248B2 (en) * 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US6902935B2 (en) * 1999-12-15 2005-06-07 Medispectra, Inc. Methods of monitoring effects of chemical agents on a sample
US7187810B2 (en) * 1999-12-15 2007-03-06 Medispectra, Inc. Methods and systems for correcting image misalignment
US6839661B2 (en) * 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US20040073120A1 (en) * 2002-04-05 2004-04-15 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US6818903B2 (en) * 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US6768918B2 (en) * 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US20040199052A1 (en) 2003-04-01 2004-10-07 Scimed Life Systems, Inc. Endoscopic imaging system
US20040209237A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US7469160B2 (en) * 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US20040208390A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for processing image data for use in tissue characterization
US7136518B2 (en) * 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US7459696B2 (en) * 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US7309867B2 (en) * 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US9820641B2 (en) 2003-04-29 2017-11-21 Aircraft Medical Limited Laryngoscope with camera attachment
US7427024B1 (en) 2003-12-17 2008-09-23 Gazdzinski Mark J Chattel management apparatus and methods
US20050234526A1 (en) * 2004-04-14 2005-10-20 Gilhuly Terence J Systems and methods for detection of disease including oral scopes and ambient light management systems (ALMS)
US7303528B2 (en) * 2004-05-18 2007-12-04 Scimed Life Systems, Inc. Serialization of single use endoscopes
US7239379B2 (en) * 2004-09-13 2007-07-03 Technology Innovations, Llc Method and apparatus for determining a vertical intensity profile through a plane of focus in a confocal microscope
US7474393B2 (en) * 2004-09-13 2009-01-06 Joel C. Wojciechowski Method and apparatus for determining a vertical intensity profile along an illuminating beam
WO2006039797A1 (en) * 2004-10-12 2006-04-20 Led Medical Diagnostics, Inc. Systems and methods relating to colposcopic viewing tubes for enhanced viewing andexamination
JP2008535186A (en) * 2005-04-01 2008-08-28 ウェルチ アレン インコーポレーテッド Vaginal speculum instrument
US8388523B2 (en) * 2005-04-01 2013-03-05 Welch Allyn, Inc. Medical diagnostic instrument having portable illuminator
US20060293644A1 (en) * 2005-06-21 2006-12-28 Donald Umstadter System and methods for laser-generated ionizing radiation
US7988633B2 (en) 2005-10-12 2011-08-02 Volcano Corporation Apparatus and method for use of RFID catheter intelligence
US20070239083A1 (en) * 2006-01-18 2007-10-11 Axel Voss Shock wave generators
US20080045799A1 (en) * 2006-04-10 2008-02-21 Peter Whitehead Multipurpose diseased tissue detection devices, systems, and methods
WO2008080121A1 (en) * 2006-12-22 2008-07-03 Cornova, Inc. Fluid media for bio-sensitive applications
US20080319510A1 (en) * 2007-06-19 2008-12-25 Simpson Fred A Medical Device Access Control Apparatus and Method
US7672813B2 (en) * 2007-12-03 2010-03-02 Smiths Detection Inc. Mixed statistical and numerical model for sensor array detection and classification
WO2009089372A2 (en) * 2008-01-08 2009-07-16 Cornova, Inc. Systems and methods for analysis and treatment of a body lumen
WO2009116029A2 (en) * 2008-03-17 2009-09-24 Or-Nim Medical Ltd. Apparatus for non invasive optical monitoring
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
EP2263107A4 (en) 2008-04-10 2016-12-28 Services Pétroliers Schlumberger Method for characterizing a geological formation traversed by a borehole
US8725477B2 (en) 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
US8648932B2 (en) * 2009-08-13 2014-02-11 Olive Medical Corporation System, apparatus and methods for providing a single use imaging device for sterile environments
US8540709B2 (en) * 2009-12-07 2013-09-24 Covidien Lp Removable ink for surgical instrument
CN109905669A (en) * 2010-03-25 2019-06-18 德普伊辛迪斯制品公司 The system and method for disposable imaging device for medical application are provided
JP6000702B2 (en) * 2012-07-12 2016-10-05 オリンパス株式会社 Medical system
US20140024931A1 (en) * 2012-07-20 2014-01-23 Lightlab Imaging, Inc. Data Encoders for Medical Devices and Related Methods
US9211053B2 (en) * 2012-07-24 2015-12-15 Olympus Corporation Medical apparatus, disposable medical device, and medical system
US8789243B2 (en) * 2012-09-19 2014-07-29 Ecolab Usa Inc. Disposable handle cover for a surgical lighthead
DE202013100349U1 (en) * 2013-01-25 2013-04-23 Nawa-Heilmittel Gmbh handheld instrument
EP2856926A1 (en) 2013-10-04 2015-04-08 Tidi Products, LLC Sheath for a medical or dental instrument
US10238363B2 (en) 2014-08-21 2019-03-26 Richard D. Striano Needle guide for ultrasound transducer

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632865A (en) * 1969-12-23 1972-01-04 Bell Telephone Labor Inc Predictive video encoding using measured subject velocity
US3809072A (en) * 1971-10-07 1974-05-07 Med General Inc Sterile sheath apparatus for fiber optic illuminator with compatible lens
US4017192A (en) * 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
US4071020A (en) * 1976-06-03 1978-01-31 Xienta, Inc. Apparatus and methods for performing in-vivo measurements of enzyme activity
US4198571A (en) * 1977-04-28 1980-04-15 National Research Development Corporation Scanning microscopes
US4254421A (en) * 1979-12-05 1981-03-03 Communications Satellite Corporation Integrated confocal electromagnetic wave lens and feed antenna system
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
US4641352A (en) * 1984-07-12 1987-02-03 Paul Fenster Misregistration correction
US4646722A (en) * 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4662360A (en) * 1984-10-23 1987-05-05 Intelligent Medical Systems, Inc. Disposable speculum
US4733063A (en) * 1985-12-13 1988-03-22 Hitachi, Ltd. Scanning laser microscope with aperture alignment
US4741326A (en) * 1986-10-01 1988-05-03 Fujinon, Inc. Endoscope disposable sheath
US4800571A (en) * 1988-01-11 1989-01-24 Tektronix, Inc. Timing jitter measurement display
US4803049A (en) * 1984-12-12 1989-02-07 The Regents Of The University Of California pH-sensitive optrode
US4891829A (en) * 1986-11-19 1990-01-02 Exxon Research And Engineering Company Method and apparatus for utilizing an electro-optic detector in a microtomography system
US4997242A (en) * 1988-03-07 1991-03-05 Medical Research Council Achromatic scanning system
US5003979A (en) * 1989-02-21 1991-04-02 University Of Virginia System and method for the noninvasive identification and display of breast lesions and the like
US5011243A (en) * 1986-09-16 1991-04-30 Laser Precision Corporation Reflectance infrared microscope having high radiation throughput
US5083220A (en) * 1990-03-22 1992-01-21 Tandem Scanning Corporation Scanning disks for use in tandem scanning reflected light microscopes and other optical systems
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5101825A (en) * 1988-10-28 1992-04-07 Blackbox, Inc. Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination
US5192980A (en) * 1990-06-27 1993-03-09 A. E. Dixon Apparatus and method for method for spatially- and spectrally-resolved measurements
US5193525A (en) * 1990-11-30 1993-03-16 Vision Sciences Antiglare tip in a sheath for an endoscope
US5199431A (en) * 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
US5201908A (en) * 1991-06-10 1993-04-13 Endomedical Technologies, Inc. Sheath for protecting endoscope from contamination
US5201318A (en) * 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5284149A (en) * 1992-01-23 1994-02-08 Dhadwal Harbans S Method and apparatus for determining the physical characteristics of ocular tissue
US5286964A (en) * 1991-02-19 1994-02-15 Phoenix Laser Systems, Inc. System for detecting, correcting and measuring depth movement of a target
US5289274A (en) * 1991-02-06 1994-02-22 Sony Corporation Electronic image stabilization apparatus
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5296700A (en) * 1991-09-12 1994-03-22 Nikon Corporation Fluorescent confocal microscope with chromatic aberration compensation
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5306902A (en) * 1992-09-01 1994-04-26 International Business Machines Corporation Confocal method and apparatus for focusing in projection lithography
US5313567A (en) * 1991-06-13 1994-05-17 At&T Bell Laboratories Arrangement for determining and displaying volumetric data in an imaging system
US5383874A (en) * 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5400267A (en) * 1992-12-08 1995-03-21 Hemostatix Corporation Local in-device memory feature for electrically powered medical equipment
US5398685A (en) * 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
US5402768A (en) * 1992-09-01 1995-04-04 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5406939A (en) * 1994-02-14 1995-04-18 Bala; Harry Endoscope sheath
US5412563A (en) * 1993-09-16 1995-05-02 General Electric Company Gradient image segmentation method
US5413092A (en) * 1991-06-24 1995-05-09 Xomed-Treace, Inc. Sheath for endoscope
US5413108A (en) * 1993-04-21 1995-05-09 The Research Foundation Of City College Of New York Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor
US5415157A (en) * 1993-02-05 1995-05-16 Welcome; Steven Damage preventing endoscope head cover
US5418797A (en) * 1993-01-15 1995-05-23 The United States Of America As Represented By The Secretary Of The Navy Time gated imaging through scattering material using polarization and stimulated raman amplification
US5419311A (en) * 1993-02-18 1995-05-30 Olympus Optical Co., Ltd. Endoscope apparatus of a type having cover for covering the endoscope
US5419323A (en) * 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5480775A (en) * 1990-01-26 1996-01-02 Canon Kabushiki Kaisha Method for measuring a specimen by the use of fluorescent light
US5493444A (en) * 1994-04-28 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Photorefractive two-beam coupling nonlinear joint transform correlator
US5496259A (en) * 1993-09-13 1996-03-05 Welch Allyn, Inc. Sterile protective sheath and drape for video laparoscope and method of use
US5507295A (en) * 1992-07-01 1996-04-16 British Technology Group Limited Medical devices
US5596992A (en) * 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5609560A (en) * 1992-08-19 1997-03-11 Olympus Optical Co., Ltd. Medical operation device control system for controlling a operation devices accessed respectively by ID codes
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
US5623932A (en) * 1993-05-12 1997-04-29 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluorescence
US5704892A (en) * 1992-09-01 1998-01-06 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5707343A (en) * 1984-10-23 1998-01-13 O'hara; Gary J. Disposable sanitary speculum for timpanic thermometer probe
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5717209A (en) * 1996-04-29 1998-02-10 Petrometrix Ltd. System for remote transmission of spectral information through communication optical fibers for real-time on-line hydrocarbons process analysis by near infra red spectroscopy
US5720293A (en) * 1991-01-29 1998-02-24 Baxter International Inc. Diagnostic catheter with memory
US5732401A (en) * 1996-03-29 1998-03-24 Intellitecs International Ltd. Activity based cost tracking systems
US5730701A (en) * 1995-09-12 1998-03-24 Olympus Optical Co., Ltd. Endoscope
US5733244A (en) * 1995-03-13 1998-03-31 Asahi Kogaku Kogyo Kabushiki Kaisha Distal end part of endoscope
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5740808A (en) * 1996-10-28 1998-04-21 Ep Technologies, Inc Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US5855551A (en) * 1997-03-17 1999-01-05 Polartechnics Limited Integral sheathing apparatus for tissue recognition probes
US5860913A (en) * 1996-05-16 1999-01-19 Olympus Optical Co., Ltd. Endoscope whose distal cover can be freely detachably attached to main distal part thereof with high positioning precision
US5863287A (en) * 1995-10-04 1999-01-26 Fuji Photo Optical Co., Ltd. Removable protector sheath for use with endoscopic insertion instrument
US5865726A (en) * 1996-03-27 1999-02-02 Asahi Kogaku Kogyo Kabushiki Kaisha Front end structure of side-view type endoscope
US5871439A (en) * 1995-01-18 1999-02-16 Asahi Kogaku Kogyo Kabushiki Kaisha Endoscope system transmitting a magnification ratio to an external processing device
US5876329A (en) * 1996-08-08 1999-03-02 Vision-Sciences, Inc. Endoscope with sheath retaining device
US5894340A (en) * 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
US6011596A (en) * 1991-05-24 2000-01-04 British Broadcasting Video image motion compensation using an algorithm involving at least two fields
US6021344A (en) * 1996-12-04 2000-02-01 Derma Technologies, Inc. Fluorescence scope system for dermatologic diagnosis
US6026331A (en) * 1993-07-27 2000-02-15 Microsulis Limited Treatment apparatus
US6169817B1 (en) * 1998-11-04 2001-01-02 University Of Rochester System and method for 4D reconstruction and visualization
US6187289B1 (en) * 1997-10-20 2001-02-13 Board Of Regents, The University Of Texas System Acetic acid as a contrast in reflectance confocal imaging of tissue
US6193510B1 (en) * 1999-07-28 2001-02-27 Efraim Tsimerman Medical device with time-out feature
US6208887B1 (en) * 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US6210331B1 (en) * 1996-06-26 2001-04-03 Morphometrix Technologies Inc. Confocal ultrasonic imaging system
US20020007123A1 (en) * 2000-03-28 2002-01-17 Constantinos Balas Method and system for characterization and mapping of tissue lesions
USD453832S1 (en) * 2001-02-09 2002-02-19 Medispectra, Inc. Sheath for cervical optical probe
USD453963S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453962S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453964S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
US6370422B1 (en) * 1998-03-19 2002-04-09 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US6373998B2 (en) * 1997-05-21 2002-04-16 Inria Institut National Dn Recherche En Informatique Et En Automatique Image processing electronic device for detecting dimensional variations
US6377842B1 (en) * 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6537207B1 (en) * 1999-04-07 2003-03-25 Fovioptics, Inc. Identification of protective covers for medical imaging devices
US20040007674A1 (en) * 2002-07-09 2004-01-15 Schomacker Kevin T. Method and apparatus for identifying spectral artifacts
US20040010375A1 (en) * 2002-07-09 2004-01-15 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US20040010187A1 (en) * 2002-07-10 2004-01-15 Schomacker Kevin T. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US20040010195A1 (en) * 2002-07-10 2004-01-15 Zelenchuk Alex R. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US20040023406A1 (en) * 2002-07-09 2004-02-05 Schomacker Kevin T. Optimal windows for obtaining optical data for characterization of tissue samples
US6697666B1 (en) * 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US6847490B1 (en) * 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013467A (en) 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US3890462A (en) 1974-04-17 1975-06-17 Bell Telephone Labor Inc Speed and direction indicator for video systems
US3963019A (en) 1974-11-25 1976-06-15 Quandt Robert S Ocular testing method and apparatus
FR2430754A1 (en) 1978-07-13 1980-02-08 Groux Jean Endoscope ultraviolet
US4218703A (en) 1979-03-16 1980-08-19 Bell Telephone Laboratories, Incorporated Technique for estimation of displacement and/or velocity of objects in video scenes
US4357075A (en) 1979-07-02 1982-11-02 Hunter Thomas M Confocal reflector system
DE2951459C2 (en) 1979-12-20 1984-03-29 Heimann Gmbh, 6200 Wiesbaden, De
DE3175632D1 (en) 1980-08-21 1987-01-08 Oriel Scient Ltd Analytical optical instruments
CA1201198A (en) 1982-02-01 1986-02-25 Sony Corporation Method and apparatus for compensating for tape jitter during recording and reproducing of a video signal andpcm audio signal
JPH0233190B2 (en) 1982-09-02 1990-07-25 Hitachi Medical Corp
US5139025A (en) 1983-10-14 1992-08-18 Somanetics Corporation Method and apparatus for in vivo optical spectroscopic examination
SE455736B (en) 1984-03-15 1988-08-01 Sarastro Ab Forfaringssett and apparatus for microphotometering and subsequent image together tell accession
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US5042494A (en) 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
JPS62247232A (en) 1986-04-21 1987-10-28 Agency Of Ind Science & Technol Fluorescence measuring apparatus
US4852955A (en) 1986-09-16 1989-08-01 Laser Precision Corporation Microscope for use in modular FTIR spectrometer system
NL8603108A (en) 1986-12-08 1988-07-01 Philips Nv Microscope.
CA1300369C (en) 1987-03-24 1992-05-12 Timothy P. Dabbs Distance measuring device
US5235457A (en) 1987-09-24 1993-08-10 Washington University Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope
US4945478A (en) 1987-11-06 1990-07-31 Center For Innovative Technology Noninvasive medical imaging system and method for the identification and 3-D display of atherosclerosis and the like
US4844617A (en) 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
FR2626383B1 (en) 1988-01-27 1991-10-25 Commissariat Energie Atomique Method of scanning confocal optical microscopy and has extended depth of field and devices for implementation of METHOD
US5032720A (en) 1988-04-21 1991-07-16 White John G Confocal imaging system
US4877033A (en) 1988-05-04 1989-10-31 Seitz Jr H Michael Disposable needle guide and examination sheath for transvaginal ultrasound procedures
DE8808299U1 (en) 1988-06-25 1989-07-20 Effner Gmbh, 1000 Berlin, De
EP0393165B2 (en) 1988-07-13 2007-07-25 Optiscan Pty Ltd Scanning confocal endoscope
CA1325537C (en) 1988-08-01 1993-12-28 Timothy Peter Dabbs Confocal microscope
US5036853A (en) 1988-08-26 1991-08-06 Polartechnics Ltd. Physiological probe
US5022757A (en) 1989-01-23 1991-06-11 Modell Mark D Heterodyne system and method for sensing a target substance
US4878485A (en) 1989-02-03 1989-11-07 Adair Edwin Lloyd Rigid video endoscope with heat sterilizable sheath
US4972258A (en) 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
JPH0378720A (en) 1989-08-22 1991-04-03 Nikon Corp Confocal laser scanning microscope
US5065008A (en) 1989-10-18 1991-11-12 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
DE8912757U1 (en) 1989-10-27 1989-12-07 Fa. Carl Zeiss, 7920 Heidenheim, De
US4979498A (en) 1989-10-30 1990-12-25 Machida Incorporated Video cervicoscope system
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5257617A (en) 1989-12-25 1993-11-02 Asahi Kogaku Kogyo Kabushiki Kaisha Sheathed endoscope and sheath therefor
US5028802A (en) 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
JPH0742401Y2 (en) 1990-02-01 1995-10-04 株式会社町田製作所 The endoscope cover
JPH03101903U (en) 1990-02-01 1991-10-23
US5074306A (en) 1990-02-22 1991-12-24 The General Hospital Corporation Measurement of burn depth in skin
JP2613118B2 (en) 1990-04-10 1997-05-21 富士写真フイルム株式会社 Confocal scanning microscope
US5048946A (en) 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
GB9016587D0 (en) 1990-07-27 1990-09-12 Isis Innovation Infra-red scanning microscopy
US5324979A (en) 1990-09-26 1994-06-28 Futrex, Inc. Method and means for generating synthetic spectra allowing quantitative measurement in near infrared measuring instruments
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5168157A (en) 1990-11-20 1992-12-01 Fuji Photo Film Co., Ltd. Scanning microscope with means for detecting a first and second polarized light beams along first and second optical receiving paths
US5261410A (en) 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US5260578A (en) 1991-04-10 1993-11-09 Mayo Foundation For Medical Education And Research Confocal imaging system for visible and ultraviolet light
DE4111903C2 (en) 1991-04-12 1993-02-04 Bayer Ag, 5090 Leverkusen, De
JP3479069B2 (en) 1991-04-29 2003-12-15 マサチューセッツ・インステチュート・オブ・テクノロジー Method and apparatus for optical imaging and measurement
JP2975719B2 (en) 1991-05-29 1999-11-10 オリンパス光学工業株式会社 Confocal optical system
US5319200A (en) 1991-06-05 1994-06-07 Zeltex, Inc. Rapid near-infrared measurement of nonhomogeneous samples
US5162941A (en) 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
JPH0527177A (en) 1991-07-25 1993-02-05 Fuji Photo Film Co Ltd Scanning type microscope
US5253071A (en) 1991-12-20 1993-10-12 Sony Corporation Of America Method and apparatus for stabilizing an image produced in a video camera
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5325846A (en) 1992-07-27 1994-07-05 Linvatec Corporation Endoscopic draping apparatus and method
US5987343A (en) * 1997-11-07 1999-11-16 Datascope Investment Corp. Method for storing pulse oximetry sensor characteristics
US6497659B1 (en) * 1999-04-09 2002-12-24 Spacelabs Medical, Inc. System for identifying a cable transmitting a signal from a sensor to an electronic instrument

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632865A (en) * 1969-12-23 1972-01-04 Bell Telephone Labor Inc Predictive video encoding using measured subject velocity
US3809072A (en) * 1971-10-07 1974-05-07 Med General Inc Sterile sheath apparatus for fiber optic illuminator with compatible lens
US4017192A (en) * 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
US4071020A (en) * 1976-06-03 1978-01-31 Xienta, Inc. Apparatus and methods for performing in-vivo measurements of enzyme activity
US4198571A (en) * 1977-04-28 1980-04-15 National Research Development Corporation Scanning microscopes
US4254421A (en) * 1979-12-05 1981-03-03 Communications Satellite Corporation Integrated confocal electromagnetic wave lens and feed antenna system
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
US4641352A (en) * 1984-07-12 1987-02-03 Paul Fenster Misregistration correction
US5707343A (en) * 1984-10-23 1998-01-13 O'hara; Gary J. Disposable sanitary speculum for timpanic thermometer probe
US4662360A (en) * 1984-10-23 1987-05-05 Intelligent Medical Systems, Inc. Disposable speculum
US4646722A (en) * 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4803049A (en) * 1984-12-12 1989-02-07 The Regents Of The University Of California pH-sensitive optrode
US5199431A (en) * 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
US4733063A (en) * 1985-12-13 1988-03-22 Hitachi, Ltd. Scanning laser microscope with aperture alignment
US5011243A (en) * 1986-09-16 1991-04-30 Laser Precision Corporation Reflectance infrared microscope having high radiation throughput
US4741326A (en) * 1986-10-01 1988-05-03 Fujinon, Inc. Endoscope disposable sheath
US4891829A (en) * 1986-11-19 1990-01-02 Exxon Research And Engineering Company Method and apparatus for utilizing an electro-optic detector in a microtomography system
US4800571A (en) * 1988-01-11 1989-01-24 Tektronix, Inc. Timing jitter measurement display
US4997242A (en) * 1988-03-07 1991-03-05 Medical Research Council Achromatic scanning system
US5101825A (en) * 1988-10-28 1992-04-07 Blackbox, Inc. Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination
US5419323A (en) * 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5003979A (en) * 1989-02-21 1991-04-02 University Of Virginia System and method for the noninvasive identification and display of breast lesions and the like
US5201318A (en) * 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5480775A (en) * 1990-01-26 1996-01-02 Canon Kabushiki Kaisha Method for measuring a specimen by the use of fluorescent light
US5083220A (en) * 1990-03-22 1992-01-21 Tandem Scanning Corporation Scanning disks for use in tandem scanning reflected light microscopes and other optical systems
US5192980A (en) * 1990-06-27 1993-03-09 A. E. Dixon Apparatus and method for method for spatially- and spectrally-resolved measurements
US5193525A (en) * 1990-11-30 1993-03-16 Vision Sciences Antiglare tip in a sheath for an endoscope
US5720293A (en) * 1991-01-29 1998-02-24 Baxter International Inc. Diagnostic catheter with memory
US5289274A (en) * 1991-02-06 1994-02-22 Sony Corporation Electronic image stabilization apparatus
US5286964A (en) * 1991-02-19 1994-02-15 Phoenix Laser Systems, Inc. System for detecting, correcting and measuring depth movement of a target
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US6011596A (en) * 1991-05-24 2000-01-04 British Broadcasting Video image motion compensation using an algorithm involving at least two fields
US5201908A (en) * 1991-06-10 1993-04-13 Endomedical Technologies, Inc. Sheath for protecting endoscope from contamination
US5313567A (en) * 1991-06-13 1994-05-17 At&T Bell Laboratories Arrangement for determining and displaying volumetric data in an imaging system
US5413092A (en) * 1991-06-24 1995-05-09 Xomed-Treace, Inc. Sheath for endoscope
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5296700A (en) * 1991-09-12 1994-03-22 Nikon Corporation Fluorescent confocal microscope with chromatic aberration compensation
US5383874A (en) * 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5398685A (en) * 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
US5284149A (en) * 1992-01-23 1994-02-08 Dhadwal Harbans S Method and apparatus for determining the physical characteristics of ocular tissue
US5507295A (en) * 1992-07-01 1996-04-16 British Technology Group Limited Medical devices
US5609560A (en) * 1992-08-19 1997-03-11 Olympus Optical Co., Ltd. Medical operation device control system for controlling a operation devices accessed respectively by ID codes
US5402768A (en) * 1992-09-01 1995-04-04 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5306902A (en) * 1992-09-01 1994-04-26 International Business Machines Corporation Confocal method and apparatus for focusing in projection lithography
US5704892A (en) * 1992-09-01 1998-01-06 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5400267A (en) * 1992-12-08 1995-03-21 Hemostatix Corporation Local in-device memory feature for electrically powered medical equipment
US5418797A (en) * 1993-01-15 1995-05-23 The United States Of America As Represented By The Secretary Of The Navy Time gated imaging through scattering material using polarization and stimulated raman amplification
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5415157A (en) * 1993-02-05 1995-05-16 Welcome; Steven Damage preventing endoscope head cover
US5419311A (en) * 1993-02-18 1995-05-30 Olympus Optical Co., Ltd. Endoscope apparatus of a type having cover for covering the endoscope
US5413108A (en) * 1993-04-21 1995-05-09 The Research Foundation Of City College Of New York Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor
US5623932A (en) * 1993-05-12 1997-04-29 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluorescence
US5596992A (en) * 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US6026331A (en) * 1993-07-27 2000-02-15 Microsulis Limited Treatment apparatus
US5496259A (en) * 1993-09-13 1996-03-05 Welch Allyn, Inc. Sterile protective sheath and drape for video laparoscope and method of use
US5412563A (en) * 1993-09-16 1995-05-02 General Electric Company Gradient image segmentation method
US5406939A (en) * 1994-02-14 1995-04-18 Bala; Harry Endoscope sheath
US5493444A (en) * 1994-04-28 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Photorefractive two-beam coupling nonlinear joint transform correlator
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5871439A (en) * 1995-01-18 1999-02-16 Asahi Kogaku Kogyo Kabushiki Kaisha Endoscope system transmitting a magnification ratio to an external processing device
US5894340A (en) * 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
US5733244A (en) * 1995-03-13 1998-03-31 Asahi Kogaku Kogyo Kabushiki Kaisha Distal end part of endoscope
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5730701A (en) * 1995-09-12 1998-03-24 Olympus Optical Co., Ltd. Endoscope
US5863287A (en) * 1995-10-04 1999-01-26 Fuji Photo Optical Co., Ltd. Removable protector sheath for use with endoscopic insertion instrument
US5865726A (en) * 1996-03-27 1999-02-02 Asahi Kogaku Kogyo Kabushiki Kaisha Front end structure of side-view type endoscope
US5732401A (en) * 1996-03-29 1998-03-24 Intellitecs International Ltd. Activity based cost tracking systems
US5717209A (en) * 1996-04-29 1998-02-10 Petrometrix Ltd. System for remote transmission of spectral information through communication optical fibers for real-time on-line hydrocarbons process analysis by near infra red spectroscopy
US5860913A (en) * 1996-05-16 1999-01-19 Olympus Optical Co., Ltd. Endoscope whose distal cover can be freely detachably attached to main distal part thereof with high positioning precision
US6210331B1 (en) * 1996-06-26 2001-04-03 Morphometrix Technologies Inc. Confocal ultrasonic imaging system
US5876329A (en) * 1996-08-08 1999-03-02 Vision-Sciences, Inc. Endoscope with sheath retaining device
US5740808A (en) * 1996-10-28 1998-04-21 Ep Technologies, Inc Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US6021344A (en) * 1996-12-04 2000-02-01 Derma Technologies, Inc. Fluorescence scope system for dermatologic diagnosis
US6847490B1 (en) * 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US5855551A (en) * 1997-03-17 1999-01-05 Polartechnics Limited Integral sheathing apparatus for tissue recognition probes
US6373998B2 (en) * 1997-05-21 2002-04-16 Inria Institut National Dn Recherche En Informatique Et En Automatique Image processing electronic device for detecting dimensional variations
US6187289B1 (en) * 1997-10-20 2001-02-13 Board Of Regents, The University Of Texas System Acetic acid as a contrast in reflectance confocal imaging of tissue
US6370422B1 (en) * 1998-03-19 2002-04-09 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US6377842B1 (en) * 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6169817B1 (en) * 1998-11-04 2001-01-02 University Of Rochester System and method for 4D reconstruction and visualization
US6537207B1 (en) * 1999-04-07 2003-03-25 Fovioptics, Inc. Identification of protective covers for medical imaging devices
US6697666B1 (en) * 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US6208887B1 (en) * 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US6193510B1 (en) * 1999-07-28 2001-02-27 Efraim Tsimerman Medical device with time-out feature
US20020007123A1 (en) * 2000-03-28 2002-01-17 Constantinos Balas Method and system for characterization and mapping of tissue lesions
US20050054936A1 (en) * 2000-03-28 2005-03-10 Constantinos Balas Method and system for characterization and mapping of tissue lesions
US20050090751A1 (en) * 2000-03-28 2005-04-28 Foundation For Research And Technology Method and system for characterization and mapping of tissue lesions
USD453963S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453832S1 (en) * 2001-02-09 2002-02-19 Medispectra, Inc. Sheath for cervical optical probe
USD453964S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453962S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
US20040023406A1 (en) * 2002-07-09 2004-02-05 Schomacker Kevin T. Optimal windows for obtaining optical data for characterization of tissue samples
US20040007674A1 (en) * 2002-07-09 2004-01-15 Schomacker Kevin T. Method and apparatus for identifying spectral artifacts
US20040010375A1 (en) * 2002-07-09 2004-01-15 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US20040010187A1 (en) * 2002-07-10 2004-01-15 Schomacker Kevin T. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US20040010195A1 (en) * 2002-07-10 2004-01-15 Zelenchuk Alex R. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090118581A1 (en) * 1999-11-15 2009-05-07 Gavriel Meron Method for activating an image collecting process
US7907643B2 (en) 2002-07-25 2011-03-15 Angiodynamics, Inc. Laser system
US20050288594A1 (en) * 2002-11-29 2005-12-29 Shlomo Lewkowicz Methods, device and system for in vivo diagnosis
US9839361B2 (en) 2005-01-24 2017-12-12 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US9161694B2 (en) 2005-01-24 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US20070112253A1 (en) * 2005-11-15 2007-05-17 Pentax Corporation Endoscope light source unit
US7828726B2 (en) * 2005-11-15 2010-11-09 Hoya Corporation Endoscope light source unit
WO2007138552A3 (en) * 2006-05-30 2008-03-06 Joachim Kahlert Apparatus for depth-resolved measurements of properties of tissue
US8417323B2 (en) 2006-05-30 2013-04-09 Koninklijke Philips Electronics N.V. Apparatus for depth-resolved measurements of properties of tissue
US20090143774A1 (en) * 2006-05-30 2009-06-04 Koninklijke Philips Electronics N.V. Apparatus for depth-resolved measurements of properties of tissue
US20080294002A1 (en) * 2006-08-22 2008-11-27 Olympus Corporation Endoscope apparatus and endoscope probe
US8068890B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Pulse oximetry sensor switchover
US20090284588A1 (en) * 2007-02-05 2009-11-19 Olympus Corporation Endoscope apparatus
US8366610B2 (en) * 2007-02-05 2013-02-05 Olympus Corporation Endoscope apparatus
US20090259220A1 (en) * 2008-04-09 2009-10-15 Angiodynamics, Inc. Treatment Devices and Methods
US8862194B2 (en) 2008-06-30 2014-10-14 Covidien Lp Method for improved oxygen saturation estimation in the presence of noise
US10363103B2 (en) 2009-04-29 2019-07-30 Auris Health, Inc. Flexible and steerable elongate instruments with shape control and support elements
US20100300922A1 (en) * 2009-05-27 2010-12-02 Zvika Gilad System and method for storing and activating an in vivo imaging capsule
US7931149B2 (en) 2009-05-27 2011-04-26 Given Imaging Ltd. System for storing and activating an in vivo imaging capsule
US20110098576A1 (en) * 2009-12-01 2011-04-28 Hollstien David S Non-invasive implant rupture detection system
US9113844B2 (en) 2009-12-01 2015-08-25 David S. Hollstien Non-invasive implant rupture detection system
US10130427B2 (en) 2010-09-17 2018-11-20 Auris Health, Inc. Systems and methods for positioning an elongate member inside a body
EP2462859A1 (en) * 2010-12-09 2012-06-13 IFM-Gerbershagen GmbH Protective sleeve for a laparoscope
US10080576B2 (en) 2013-03-08 2018-09-25 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
US10149720B2 (en) 2013-03-08 2018-12-11 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
WO2014144307A3 (en) * 2013-03-15 2015-01-29 Oncoscope, Inc. Probe assembly and disposable cover particularly for use in endoscope applications of low coherence interferometry
US10376672B2 (en) 2013-03-15 2019-08-13 Auris Health, Inc. Catheter insertion system and method of fabrication
EP2910177A1 (en) * 2014-02-19 2015-08-26 Everest Display Inc. Gastrointestinal tract diagnosis device with disposable endoscope and control method for the same
WO2019091695A1 (en) * 2017-11-10 2019-05-16 Böllhoff Verbindungstechnik GmbH Sanitary protective cap

Also Published As

Publication number Publication date
US6847490B1 (en) 2005-01-25

Similar Documents

Publication Publication Date Title
EP1267707B1 (en) Method and system for characterization and mapping of tissue lesions
US5536236A (en) Covered endoscope system
US6045502A (en) Analyzing system with disposable calibration device
US6035229A (en) Method and apparatus for detecting Barrett's metaplasia of the esophagus
CA2589516C (en) Pulsed lighting imaging systems and methods
US4825850A (en) Contamination protection system for endoscope control handles
US4722000A (en) Adapter for endoscopic camera
US6324418B1 (en) Portable tissue spectroscopy apparatus and method
EP0925034B1 (en) Device for diagnosing and performing interventional procedures on tissue in vivo
EP1379163B1 (en) System for detection and removal of dental tartar
CN1802560B (en) Methods and apparatus for fluorescence imaging using multiple excitation-emission pairs and simultaneous multi-channel image detection
JP4163755B2 (en) Apparatus for rotatably connecting optical fibers
EP1029414B1 (en) Video rectoscope
US6863650B1 (en) Endoscopic instrument for performing endoscopic procedures or examinations
US5941817A (en) Endoscope wherein electrical components are electrically isolated from patient-engaging components
US20050059894A1 (en) Automated endoscopy device, diagnostic method, and uses
JP3914497B2 (en) Temperature measurement balloon
JP6066901B2 (en) Method for device and device for imaging the one or more hollow organ or in the structures in the hollow organs
US9622682B2 (en) Medical device with OLED illumination light source
US6383209B1 (en) Sheath for tissue spectroscopy
CA2343401C (en) Multi-modal optical tissue diagnostic system
JP4488280B2 (en) Instrument for an endoscope and endoscopic device
Utzinger et al. Fiber optic probes for biomedical optical spectroscopy
US8452384B2 (en) Systems and methods for sidesstream dark field imaging
US5738630A (en) Endoscope system including endoscope and protection cover

Legal Events

Date Code Title Description
AS Assignment

Owner name: PRODUCT GENESIS, INC., MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KWO, JENNIE;EMANS, MATTHEW;REEL/FRAME:016074/0753

Effective date: 20010130

Owner name: MEDISPECTRA, INC., MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:NORDSTROM, ROBERT;BEE, DAVID;MODELL, MARK;AND OTHERS;REEL/FRAME:016067/0132;SIGNING DATES FROM 20010130 TO 20011212

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION