US20040153008A1 - Probe anchor - Google Patents
Probe anchor Download PDFInfo
- Publication number
- US20040153008A1 US20040153008A1 US10/480,008 US48000803A US2004153008A1 US 20040153008 A1 US20040153008 A1 US 20040153008A1 US 48000803 A US48000803 A US 48000803A US 2004153008 A1 US2004153008 A1 US 2004153008A1
- Authority
- US
- United States
- Prior art keywords
- anchor
- probe
- tissue
- exemplary embodiment
- birth canal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4472—Wireless probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/076—Permanent implantations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1126—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique
- A61B5/1127—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique using markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6879—Means for maintaining contact with the body
- A61B5/6882—Anchoring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0866—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/02—Foetus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
- A61B2562/225—Connectors or couplings
- A61B2562/226—Connectors or couplings comprising means for identifying the connector, e.g. to prevent incorrect connection to socket
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02411—Detecting, measuring or recording pulse rate or heart rate of foetuses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
- A61B5/288—Invasive for foetal cardiography, e.g. scalp electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/56—Details of data transmission or power supply
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/56—Details of data transmission or power supply
- A61B8/565—Details of data transmission or power supply involving data transmission via a network
Definitions
- the present invention relates to anchoring a probe to biological tissue.
- Measuring cervical dilation and/or the descent of the fetus in the birth canal is considered an essential element for properly following the progress of the birth process.
- a professional attendant makes, on the average, 10 examinations of the birth canal causing the mother discomfort and/or embarrassment.
- manual exams are subjective, possibly providing inaccurate information, introducing infection into the birth canal and/or missing key events in between examinations.
- a sterile probe to the tissue adjacent the birth canal, meaning the tissue lining the birth canal, the tissue of the cervix and/or the fetus, for the purpose of monitoring the mother and/or fetus during the birth process, presents difficulties in attaching a probe anchor to the wet, moving tissue adjacent the birth canal. Additionally or alternatively, the probe anchor is routinely subject to strong, sustained movement during birth contractures, jarring during fetal presentation and can be entirely displaced due to birth canal tissue distortion and/or the baby's movement through the birth canal.
- a prior art measurement system for example, uses V calipers with a strain gauge between its arms that spans the cervix and substantially blocks other monitoring and/or treatment services.
- Another prior art measurement system for example, uses a multi-switch membrane that is inserted between the fetus and uterine wall. The placement of this membrane is technically difficult, creates obstruction of the birth area and is uncomfortable for the mother.
- Probe anchors that are implanted in the tissue of the birth canal may cause discomfort as the tissue of the cervix and/or birth canal expands during the birth process and squeezes and/or strains against the probe anchor.
- an implanted probe may cause harm to the fetus, for example if it protrudes significantly into the path of the fetal descent through the birth canal, or if it includes a sharp spike that can otherwise interact with the fetus or other birth canal adjacent tissue.
- the implanted probe may be difficult to remove from the birth canal and/or cause harm to the mother.
- One possible cause for difficulty is that the birth canal tissues following birth are typically thinned, stressed and/or dilated.
- Grafton et al. in U.S. Pat. No. 5,964,783 demonstrate a biodegradable attachment for attaching material to bone that is unsuitable for use in soft tissue probe attachment.
- An aspect of some embodiments of the present invention relates to providing a probe anchor for use during the birth process that readily attaches to and/or removes from tissue of the birth canal by operation of a control extension whose operation is effected external and/or internal to the birth canal. Operation of the control remote from the anchor allows the operator's hands to easily attach and/or remove the probe anchor in the wet, moving tissue associated with the birth process.
- a probe extension aids in the remote insertion and/or the removal of an anchor from an anchor area.
- the extension is attached to the anchor mechanism of the probe and manipulation of the extension causes deployment and/or retraction of an anchor mechanism of the probe.
- the extension is a tubular structure whose rotation, for example, causes deployment and/or retraction of an anchor mechanism of the probe.
- a probe anchored in tissue adjacent the birth canal has one or more wires that connect said probe to a monitor and provide information on the birth process.
- the probe, wires and/or their attachments provide information on fetal position and/or EKG information and can be placed in position with either left or right hand by a single operator, for example an obstetrician, without assistance from additional personnel.
- the probe, wires and/or their connections are color coded, for example, for proper positional placement.
- the probe, wires and/or their connections are sufficiently pliant, for example, that they do not present a risk to the mother and/or fetus before, during and/or after the birth process.
- the probe, wires and/or their connections do not prevent the mother from moving in association with the birth process, for example, leaning on the bed and/or walking. Additionally or alternatively, they do not obstruct the birth canal and/or manual examination of the birth canal, during the birth process.
- the wires are formed into an antenna that sends, for example radiofrequency signals, to a signal receptor connected to a monitor display.
- passage of the fetus through the birth canal is unhindered by the antenna.
- An aspect of some embodiments of the present invention relates to providing a probe anchor mechanism that secures a probe to and/or through one or more points in a tissue of the mother and/or the fetus during the birth process.
- the anchor and/or its mechanism are operable in a sterile environment and/or are disposable following use.
- the attachment is provided by a curved wire that extends from the probe through the tissue so the tissue is secured along a cord of the wire's curvature. As the cervical tissue expands and/or moves during labor, the tissue pierced by, and thus fastened with the curved wire, moves to a longer cord length position on the curved wire.
- a rigid clamp for example a rigid caliper operated by a screw mechanism that fixes the caliper jaw in place, does not expand as the amount of tissue between the jaws increases, resulting in pinching of the expanding tissue, reduction of blood supply within the fastened tissue and possible harm due to apoxia and/or local trauma as the tissue chaffs between the fixed clamp jaws.
- the probe anchor has two or more legs with sharp ends facing each other that secure in an anchor area and/or compress the tissue of the anchor area in between the sharp ends.
- the two sharp ends are flexibly attached to the probe to allow for cervical tissue movement and/or expansion during the birth process.
- a probe anchor comprises an expandable anchor that secures to a tissue by expanding within the tissue, for example a tissue adjacent the birth canal and/or other tissue areas in the body.
- An aspect of some embodiments of the present invention relates to providing a probe anchor that secures in and/or against a tissue of the birth canal and/or another body tissue whose anchor mechanism, for example a curved wire or two or more legs with sharp ends, is tensioned towards the open position.
- the curved wire and/or legs with sharp ends are pressed against a tension force, caused for example by a spring mechanism, to anchor in the tissue.
- a pin or other restraining element is provided to prevent the anchor from opening.
- this type of normally open anchor may be used to provide an anchor in which the implantation technique is decoupled from the removal technique.
- This decoupling may be exhibited, for example, by using a different method to attach and to detach the anchor.
- the decoupling is exhibited by the force required to open the device not be complementary to the force exerted by the device when it closes. This contrasts, for example, with normally closed anchors which are implanted by releasing the anchor to a closed position but require considerable force to be brought back to an open position.
- an anchor which is inserted easily and (possibly) after a while, deforms or otherwise changes so that it is also relatively easy to remove.
- the easy removal is timed and/or designed to allow the anchor to stay attached during the monitoring of part or all of a birth process.
- a probe anchor readily removes from attachment to the birth canal and/or fetus at any stage of the birth process only by action of an operator and without intrusion of the operator's hands in the birth canal.
- the anchor mechanism is maintained in the closed position with a retainer mechanism. Disengaging the retainer mechanism, for example following labor, allows the anchor mechanism to open so the probe is readily removed from the tissue.
- the open anchor mechanism adds a safety feature in that the retracted sharp end will not damage tissue during attachment and/or removal from the birth canal.
- the anchor when the anchor is implanted it is tensioned towards a closed position. Once deployed, it changes to a normally open position, for example at once, after a time period and/or due to the application of a causative effect, such as force or heat.
- a control which allows the anchor to open and/or close is located distant from the anchor area so that removal of the probe is optionally affected without necessitating placing the operator's hands in the cervix.
- An aspect of some embodiments of the present invention relates to providing a probe with an anchor attachment for attachment to a body tissue, for example, the birth canal, heart and/or intestines, whose configuration and/or surface geometry on removal is altered in respect to its configuration and/or surface geometry during placement in the birth canal.
- a curved wire and/or two or more legs with sharp ends and/or an expandable anchor deforms and/or weakens over a period of time, for example due to a chemical reaction and/or interaction with the surrounding tissue.
- the probe, its connection to the probe anchor and/or the anchor itself deforms and/or weakens, for example over several hours to several days due to, for example hydrolysis, so that with time the probe anchor becomes easier to remove and/or falls away from the anchor area.
- the probe, its connection to the probe anchor and/or the anchor itself comprise a material that deforms due to increases in temperature and/or reverts to its original form when the original temperature returns.
- an anchor probe comprises shape memory polymers that change shape in response to a temperature increase as identified by Steven Ashley in “Shape Shifters”, Scientific American , May 2001.
- An aspect of some embodiments of the invention relates to a two part soft tissue anchor, in which one part anchors directly to the soft tissue and a second part attaches to the first part.
- the attachment method allows removing the second part from the anchored part.
- the anchoring may be of various kinds, for example adhesive or mechanical (e.g., at least one spike, a barb and/or a hook).
- the anchoring is at a wrong location (or if removal is desired for other reasons)
- the second part is removed and then, optionally, a new anchoring is made at a new location.
- the old anchoring may fall out by itself (e.g., using various mechanism as described herein) or it may be removed manually, for example at a more convenient time.
- a safety tether is attached to the anchoring section, to prevent undesired migration and/or to assist removal.
- An aspect of some embodiments of the present invention relates to providing a probe anchor that secures to an anchor area, for example in the birth canal or another tissue of the body, with an bioadhesive layer.
- the bioadhesive layer attaches to an area equal to or greater than 1 square centimeter so that forces from tissue movement, for example related to movement associated with the birth process, are spread over the attachment area to prevent premature detachment of the probe from the anchor area.
- the bioadhesive layer and/or the probe anchor biodegrade and/or weaken after a base period, for example three, six, eight, twelve, eighteen and/or twenty-four hours or a period that encompasses a typical birth process or a part thereof, for example 48 hours.
- the bioadhesive layer and/or probe anchor weaken so they remove with decreasing force, such as by the pulling of the probe by an operator, or possibly they fall out by themselves.
- the time is shorter, for example 10, 20, 30 or 60 minutes or a different time suitable for a procedure, such as monitoring a small number of contractions.
- a probe anchor has a tissue bioadhesive surface that is adapted to adhere to the cervical and/or fetal tissue and a probe receiver surface adapted to receive one or more of a variety of probe attachments, for example that monitor the mother and/or fetus during childbirth.
- the probe receiver surface is adapted to receive a probe with a bioadhesive layer.
- the probe receiver surface is adapted to receive a probe, for example, with a curved wire attachment end and/or a probe with two or more legs with sharp ends.
- the probe anchor and/or its tissue bioadhesive surface deform, weaken and/or dissolve in response to an externally applied agent, for example a catalytic agent and/or electromagnetic waves, such as heat, ultrasound and/or electricity.
- an externally applied agent for example a catalytic agent and/or electromagnetic waves, such as heat, ultrasound and/or electricity.
- the electromagnetic waves and/or catalytic agent are applied so the probe, probe anchor and/or probe attachment can be easily removed from the birth canal.
- An aspect of some embodiments of the present invention relates to providing a probe with an expandable anchor to attach it to a tissue area.
- fluid for example contained in an internal reservoir
- deflation of the expandable anchor is accomplished by releasing the fluid from within the anchor, for example, using an appropriate instrument that punctures the probe.
- the expandable anchor gradually deforms following a base period, so that it looses its securing aspects to the anchor area.
- the expandable anchor gradually dissolves following a base period and looses its fluid, deflates and removes from the anchor area and/or completely dissolves.
- An aspect of some embodiments of the present invention relates to providing a probe anchor deployer apparatus that aids in deployment and/or placement of the probe anchor in, for example tissue of the os cervix and/or the tissue of the birth canal and easily separates from said probe following deployment.
- one or more probe anchors are contained in a sterile cartridge that fits into the deployer apparatus. Additionally or alternatively, one or more probe anchors fit into a deployment compartment on the deployer apparatus without a cartridge.
- the deployer apparatus cartridge and/or anchor are fully sterile during use in the birth canal. Additionally or alternatively, the parts of the deployer apparatus cartridge and/or anchor, for example, that come into contact with the tissue of the birth canal area, are sterile.
- the deployer apparatus installs a probe anchor into a tissue of the birth canal in a single action, causing deployment of the probe anchor and/or separates from said anchor and/or does not require further manual inspection.
- the deployer includes an anchoring activation mechanism that activates a corresponding anchoring mechanism of the probe.
- the deployer includes a release activator that can activate a release mechanism of the anchor, to assist in removal thereof from the cervix.
- a probe anchor that attaches a probe to a tissue adjacent a birth canal, comprising:
- a control coupled to an opposite end of said cable and operative to remotely release said release mechanism using said cable without requiring manual stabilization directly to said anchor.
- said release mechanism is mechanically operated.
- said release mechanism is electrically operated.
- said release mechanism stores a releasing energy and whereby said control releases said energy.
- the anchor comprises an energy retainer that prevents activation of said releasing energy until its release by said control.
- said probe anchor comprises two sections:
- said anchor section defines a volume suitable for receiving said probe section.
- said probe section fits in said volume and is removably coupled to said volume.
- said volume comprises one or more resilient projections that restrain said probe section from exiting said volume.
- said resilient projections release said probe section from said volume upon application of a probe-displacing force.
- said anchor section weakens over time, facilitating its removal from said tissue.
- said anchor section partially dissolves over time.
- said anchor section completely dissolves over time.
- said anchor section deforms over time.
- said deformation occurs in response to a temperature change.
- pulling said cable away from said anchor activates said mechanical release mechanism.
- rotating said cable around its axis in relation to said anchor activates said mechanical release mechanism.
- said probe comprises a sensor that monitors said tissue.
- said sensor comprises an ultrasound transducer ultrasonically coupled to said anchor section and ultrasonically coupled by said anchor section to said tissue.
- said cable comprises a conducting wire.
- said conducting wire carries signal data.
- said conducting wire is visually coded to indicate function or placement of said conducting wire.
- said conducting wire is connected to an antenna that transmits signal data.
- said probe comprises an electromagnetic RF transmitter coupled to said antenna.
- said anchor section is visually coded to indicate function or placement of said anchor section.
- said anchor section is configured so it does not obstruct the birth canal during a birth process.
- said anchor section is configured so it does not obstruct manual examination of the birth canal.
- a probe anchor that attaches a probe to soft tissue adjacent a birth canal, comprising:
- said anchor comprises a wire passed through said tissue when said anchor is in the closed position.
- said anchor comprises one or more legs with sharp ends pressed into said tissue when said anchor is in the closed position.
- release of said closure control allowing said anchor to return to the open position, is activated by an extension remote from said anchor.
- the anchor comprises a tensioning element urging said anchor to be in said closed position.
- said anchor is adapted to change from a normal closed to a normally open configuration following attachment of said probe to soft tissue.
- said tension element comprises a shape memory polymer.
- said shape memory polymer is coupled to a delaying mechanism that delays said opening of said anchor.
- said delaying mechanism comprises a material that biodegrades over a period of time during which period it prevents said a shape memory polymer from drawing said anchor into the open position.
- said delaying mechanism comprises a material that dissolves in response to an external causative factor.
- a probe that anchors in soft tissue adjacent a birth canal comprising:
- a probe defining one or more lumens
- a spike element set in each of said one or more lumens with a front end extending out of said lumen;
- a deforming element that deforms in response to temperature increase above a base temperature, connecting said spike to said lumen;
- said lumen includes a delay plug that prevents retraction of said spike element.
- said delay plug comprises a material that weakens over a period of time. Alternatively or additionally, said delay prevents retraction of said one or more spike elements for a minimum of eight hours.
- said delay plug comprises a biodegradable material.
- said delay plug comprises a material that degrades in response to an external causative factor.
- said external causative factor comprises a compound.
- said external causative factor comprises electromagnetic waves.
- an expanding probe anchor that attaches a probe to soft tissue adjacent a birth canal, comprising:
- a probe with an expandable anchor member adapted to be inserted into said soft tissue
- a valve between said reservoir and said anchor that maintains said fluid in said anchor following its flow into said anchor from said reservoir.
- said fluid reservoir is flexible and compression of said reservoir causes said fluid to move through said conduit into said anchor member.
- movement of said fluid into said anchor member causes expansion of said anchor member.
- said anchor member weakens over time and maintains said fluid for a base period of time following which it releases said fluid.
- said release occurs following a minimum of eight hours.
- said anchor member comprises a material that releases said fluid in response to an external causative factor.
- said anchor member comprises a material that releases said fluid in response to a natural biological material contained in said canal.
- a probe anchor deployment apparatus that attaches a probe anchor to soft tissue adjacent a birth canal, comprising:
- a deployment mechanism along said handle extension that deploys said anchor mechanism.
- said apparatus is adapted to carry two or more probes.
- said apparatus is adapted to carry two or more probes in a magazine.
- a second probe moves into said grasping end following deployment of a first probe.
- said anchor includes a release mechanism and wherein said apparatus is adapted to activate said release mechanism.
- an adhesive probe anchor comprising:
- an adhesive on said probe that adheres to a mucosal surface adjacent a birth canal with sufficient adherence to resist detachment due to forces generated by the birth process for a base period of time;
- a sensor removably connected to said probe.
- said base period comprises a minimum of eight hours.
- said adhesive weakens in response to biological compounds naturally contained within said canal.
- said adhesive weakens in response to an external causative factor.
- said connection between said sensor and said probe is a mechanical connection.
- said connection between said sensor and said probe is a biodegradable connection that weakens over a base period of time during which it resists detachment due to forces generated by the birth process.
- said wherein said base period comprises a minimum of eight hours.
- said weakening occurs in response to biological compounds naturally contained within said canal.
- said biodegradable connection weakens in response to an external causative factor.
- a method for securing an anchor, having a base and a curved wire having a point, to the cervix comprising;
- said probe anchor comprises an ultrasound transducer ultrasonically coupled to said anchor and attaching comprises attaching said ultrasonically coupled transducer to said cervix.
- a method for adhering a probe with a sensor to soft tissue adjacent a birth canal and monitoring fetal passage comprising:
- the method comprises removing said sensor from said soft tissue prior to said surface falling off said soft tissue.
- a two part anchor comprising:
- an anchor portion adapted to be anchored to soft tissue and including an attachment element
- a selectively attachable rider portion adapted to be attached to said attachment element.
- the anchor comprises a sensor coupled to said rider portion.
- said anchor portion is adhesive to said soft tissue.
- said anchor portion mechanically attaches to said soft tissue.
- FIG. 1 shows a cervical anchor ring attached to an anchor area, according to an embodiment of the present invention
- FIG. 2 shows an alternative view of the cervical anchor ring of FIG. 1, according to an embodiment of the present invention
- FIG. 3 shows a cervical anchor caliper attached to an anchor area, according to an embodiment of the present invention
- FIG. 4 shows a coupling anchor area, according to an embodiment of the present invention
- FIG. 5 shows a probe and bioadhesive probe attachment, according to an embodiment of the present invention
- FIGS. 6 A- 6 D illustrate the operation of a cervical anchor hook in its attachment to an anchor area, according to an embodiment of the present invention
- FIG. 7 shows a bioadhesive probe attachment, according to an embodiment of the present invention.
- FIG. 8A shows pin anchor mechanisms for use in the birth canal, according to an embodiment of the present invention
- FIGS. 8B and 8C shows embodiments of a round pin anchor, according to an embodiment of the present invention.
- FIG. 9 shows a wireless signaler, according to an embodiment of the present invention.
- FIG. 10 shows an ultrasound sensor, according to an embodiment of the present invention
- FIGS. 11 A- 11 C show a probe with a dissolvable expandable anchor tip, according to an embodiment of the present invention
- FIGS. 12A and 12B show a probe with deforming anchors in tissue, according to an embodiment of the present invention
- FIG. 13 shows a probe delivery apparatus, according to an embodiment of the present invention
- FIGS. 14 A- 14 E show different probe anchor tip designs, according to an embodiment of the present invention.
- FIGS. 15 A- 15 C show probes that differ in the location of a biodegradable section, according to an embodiment of the present invention.
- FIG. 1 shows a cervical anchor ring 100 with an exemplary attachment mechanism that attaches to an anchor area 140 , for example adjacent the birth canal, comprising tissue of the birth canal of the mother, her cervix and/or the fetus, according to an embodiment of the present invention.
- Anchor ring 100 potentially fosters robust attachment of a probe wire extension of a rod 110 to cervical tissue.
- anchor ring 100 allows easy attachment using, for example, one hand at the anchor area and the other hand outside the birth canal and/or both hands outside the birth canal.
- anchor ring 100 allows easy removal using, for example, both hands outside the birth canal and/or one hand at the anchor area and the other hand outside the birth canal.
- these potential advantages, for example one hand attachment from inside or outside the birth canal are able to be configured on all embodiments of the present invention described below.
- rod 110 passes through anchor area 140 with a sharp end 104 to secure cervical anchor ring 100 to anchor area 140 .
- multiple anchor rings 100 are packaged together in a single application kit that are appropriate for attachment at multiple sites, for example to the fetal scalp and/or one or more areas of tissue adjacent the birth canal, cervix and/or external to the mother.
- the multiple electrodes apply separately to each area of tissue adjacent the birth canal and are removed separately from each area adjacent the birth canal and attach and/or remove in any order, at any time prior, during and/or following the birth process.
- the electrodes may be applied singly and/or in any combination to the birth canal tissue, for example so one or more probes are attached to the mother and not the fetus, for example prior to the breaking of the amniotic sac.
- multiple anchor rings 100 are utilized in other monitoring procedures, for example EKG and/or EMG testing and, in fact, all the anchor devices shown as exemplary embodiments of the present invention, can be utilized with a variety of monitoring procedures.
- sharp end 104 substantially removes from a receptacle 106 by pulling rod 110 in a direction 134 .
- anchor area 140 is placed between sharp end 104 and receptacle 106 and rod 110 is moved in a direction 132 to secure in anchor area 140 for example by a spring 120 .
- spring 120 has a first end 130 that presses against a housing stop 128 and a second end 122 that presses against a rod cam 124 .
- sharp end 104 retracted from receptacle 106 spring 120 is compressed in direction 134 , creating pressure between rod cam 124 and housing stop 128 .
- anchor ring 100 that can be configured for placement with either left or right hand by a single operator as the same device is easily operated ambidextrously. Additionally or alternatively, in an exemplary embodiment of the present invention, anchor ring 100 , as is the case with other embodiments of the invention, can be placed in position by a single operator, for example an obstetrician, without additional assistance.
- rod 110 When rod 110 is released, it moves in direction 132 , extending further out of a housing 108 toward anchor area 140 due to pressure of spring 120 . Sharp end 104 passes through anchor area 140 and presses into receptacle 106 to attach cervical anchor ring 100 to anchor area 140 . Additionally or alternatively, manual pressure in direction 132 is placed against an area of a shaft end 150 so that sharp end 104 passes through anchor area 140 into receptacle 106 .
- housing 108 is optionally stabilized with one hand, for example outside the birth canal, while rod 110 is pulled in direction 134 using the other hand, for example outside the birth canal, to cause sharp end 104 to move out of receptacle 106 . Additionally or alternatively, one or both hands are placed in the birth canal during removal of anchor ring 100 .
- receptacle 106 is replaced with a sharp outcrop 142 .
- sharp end 104 and sharp outcrop 142 meet. This is useful in securing cervical anchor ring 100 directly to tissue anchor area 140 A as sharp end 104 more easily pierces tissue anchor area 140 A when sharp outcrop 142 focuses pressure on tissue 140 A at the tip of sharp end 104 .
- the ability for sharp end 104 to move toward anchor area 140 and/or away from anchor area 140 A is a feature that is shared with embodiments of the present invention described below and optionally provides an advantage by allowing safer and/or more secure attachment of anchor ring 100 and/or other probes described below.
- spring 120 is designed to exert force that retracts sharp end 104 from receptacle 106 .
- anchor 100 is placed over anchor area 140 with spring 120 pulling rod 110 in direction 134 so that sharp end 104 remains retracted from receptacle 106 .
- Pressure is placed on rod 110 , for example at an end 150 , against the action of spring 120 to cause rod 110 to extend in direction 132 , of housing 108 , through anchor area 140 .
- the maintenance of spring 120 in the retracted position until pressed in direction 134 potentially averts damage to tissue during insertion.
- rod 110 has notches 152 that digitate with housing stop 128 to lock rod 110 in position through anchor area 140 .
- shaft end area 150 is pushed in a direction 154 to disengage rod 110 from housing stop 128 .
- Rod 110 is then pulled in direction 134 and/or spring 120 automatically moves in direction 134 , and sharp end 104 disengages from receptacle 106 .
- sharp end 104 is retracted by spring 120 into housing 108 , so possible harm to the fetus and/or mother is averted.
- anchor ring 100 can be removed from the tissue of the birth canal at any time during the birth process.
- housing 108 and/or rod 110 as well as the materials comprising probe anchors in other embodiments of the present invention comprise one or more of the following materials: polyurethane, mylar, elastomer, kevlar, nylon, or metal, based upon, for example, desired strength of material and/or resistance to reactivity with body fluids.
- the variation in materials in construction of housing 108 and/or rod 110 , and other embodiments, for example, is based upon the resilience of tissue around anchor area 140 and/or 140 A, the anticipated length of implantation, and/or the proximity of housing 108 and/or rod 110 to areas of increased pressure such as adjacent the birth canal.
- housing 108 and/or rod 110 include, for example, a radiopaque area that allows it to been visible in a radiographic picture, as optionally provided in other embodiments of the present invention.
- Other materials may be used as well, for example as known in the art.
- housing 108 has a diameter of between 3.0 millimeters and 10 millimeters dependent upon desired stiffness, diameter of rod 110 and materials from which it is made.
- Rod 110 for example, has an outer diameter of between 1 millimeter and 3 millimeters, depending on the material strength, ductility and desired material stiffness.
- Other embodiments of the present invention, including their anchors and/or base to which the anchors are attached, may have similar diameters with similar size variation based upon similar application considerations.
- tissue area 140 A expands.
- tissue area 140 A occupies a chord along the radius of rod 110 .
- tissue area 140 A expands with the birth process, it occupies a larger chord along the radius of rod 110 , without causing additional pressure on tissue area 140 A that might cause discomfort to the mother.
- curved anchor is elastic.
- the anchor is placed to be parallel, orthogonal or at another angle to an expected maximal distortion direction.
- housing 108 and/or rod 110 comprise a material that degrades, so that sharp end 104 , for example, weakens so that it is readily deformed to allow housing 108 to break free of tissue anchor area 140 A. Additionally or alternatively, housing 108 and/or rod 110 biodegrade over a period of time so that they fall off anchor area 140 A by themselves.
- sharp end 104 and/or rod 110 is manufactured from shape memory polymers (SMP's) that deform, for example, due to the heat buildup, for example, from a body tissue.
- SMP's shape memory polymers
- insulation is provided, to slow down heating to a critical temperature. Deformation of sections of anchor ring 100 , allows removal of anchor ring 100 from a tissue 140 A, for example, with reduced force following a base period of attachment, as will be explained below.
- FIGS. 15 A- 15 C show a schematic diagram of a probe 1500 , each with a biodegradable section in a different location, according to different embodiments of the present invention.
- Probe 1500 comprises, for example, an anchor element 1510 that inserts into an anchor area, for example a biological tissue within the birth canal, that is connected with an isthmus 1512 to a probe body 1520 .
- Probe 1500 contains an instrumentation section 1540 that, for example, houses an ultrasound sensor that is connected to probe body 1520 by a linkage 1550 that, for example, comprises sharp end 104 or other types of attachment means noted below in other embodiments, for example, allowing removal of instrumentation section 1540 from probe body 1520 .
- biodegradable sections include anchor element 1510 , isthmus 1512 and probe body 1520 .
- biodegradable sections include anchor element 1510 , isthmus 1512 and a front body wall 1560 adjacent isthmus 1512 .
- biodegradable sections include anchor element 1510 and isthmus 1512 .
- the anchor element 1510 is implanted into an anchor area that causes the biodegredation of the various biodegradable sections.
- instrumentation section 1540 optionally including a wire extension to a monitor and/or an antenna that broadcasts information to a monitor, is removed by manipulating linkage 1550 , optionally with a mechanism located remote from probe 1500 , for example outside the birth canal.
- manipulating linkage 1550 optionally with a mechanism located remote from probe 1500 , for example outside the birth canal.
- probe 1500 , instrumentation section 1540 , linkage 1550 and/or a wire extension are manufactured from an SMP that deforms, for example, due to the heat buildup from a body tissue, so that it falls away and/or can easily be broken away from tissue 140 A following a base period of attachment.
- a melting material is used which slowly softens, melts or degrades due to body heat, pH, temperature and/or other birth canal ambient conditions.
- instrumentation section 1550 comprises an ultrasound probe, for example, that contacts the tissue area with anchor 1510 .
- isthmus 1512 is designed so that instrument section 1550 contacts the tissue over a large area.
- a coupling gel is provided between the tissue interface and instrument section 1540 .
- the anchor attachment method is designed to be rigid enough so that ultrasonic waves easily travel from the surface of the birth canal tissue.
- the design provides a short distance between the sensor and the surface.
- anchoring go section may include an aperture through which the sensor can reach and contact the tissue.
- FIG. 2 shows a cervical anchor ring 100 attached to anchor area 140 A, comprising an anchor projection 212 that projects out of a surface 220 of a coupling 200 , according to an embodiment of the present invention.
- Cervical anchor ring 100 is, for example, assembled outside the birth canal by passing rod 110 through a passage 222 of anchor area 140 A to secure cervical anchor ring 100 to coupling 200 .
- anchor area 140 A may include a guiding design (e.g., include a cone shaped depression) to assist in blind guiding of ring 100 .
- housing 108 and/or wire 110 are of a length that allows manipulation of cervical anchor ring 100 with one hand outside the birth canal and/or cervix.
- coupling 200 comprises one of the materials used in the manufacture of housing 108 and/or rod 110 above. Additionally or alternatively, these materials and/or other materials specified in the invention description, can be used in the manufacture of the various other exemplary embodiments described below.
- coupling 200 comprises, for example, biodegradable materials and dissolves, deforms and/or weakens following, for example, a base period of time.
- coupling 200 comprises an adhesive layer 210 that is, for example, a biodegradable adhesive that attaches to tissue.
- Adhesive layer 210 biodegrades during attachment so that its adherence gradually weakens. After a base period of time, according to its composition that is formulated based upon its use, adhesive layer 210 biodegrades to an adherence strength below a specific threshold level. Below this threshold level, for example, it falls off said tissue and/or removes from said with little force applied by the operator.
- adhesive layer 210 and/or coupling 200 and/or anchor 100 biodegrades below the threshold adherence level described above, over a period of 18 to 24 hours and/or a period allowing it to remain affixed through a long delivery period, for example maximally 48 hours. Additionally or alternatively, adhesive layer 210 is designed to remain attached to tissue for a longer period of time, for example a few days.
- an external causative factor for example hyaluronic acid or an alcohol derivative
- adhesive layer 210 is applied to adhesive layer 210 to cause biodegradation within a short period of time, for example a few hours.
- an external causative factor for example hyaluronic acid or an alcohol derivative
- rod 110 comprises a biodegradable material and, in an exemplary embodiment, rod 110 weakens and is easily broken away from coupling 200 , as potentially would all embodiments of the present invention when removal is required following a short period of time.
- coupling 200 and/or adhesive layer 210 can be configured to remain above an adherence threshold for relatively short periods of time, for example, for as short a period as a half an hour.
- the potential advantage of such a short adherence period is the ability to rapidly monitor a short period of contractures to determine various tissue parameters.
- coupling 0 . 100 and/or adhesive layer 210 for short observation periods for example a half hour or less, can be designed without consideration of blocking fetal passages as they would be rapidly removed at an early stage of the birth process. Following this short monitoring period, probes with the design features notes in the other embodiments of the invention can be placed along the tissue adjacent the birth canal.
- a potential advantage of using coupling 200 and/or adhesive layer 210 in attaching a probe, for example anchor ring 100 , to a tissue adjacent the birth canal is that should coupling 200 be placed improperly, anchor ring 100 can be disconnected from it and, optionally, attached to another coupling 200 placed adjacent the birth canal. Additionally or alternatively, when a probe, for example anchor ring 100 , requires multiple placement areas along a tissue of the birth canal, multiple couplings 200 can be placed throughout the area and anchor ring 100 can be moved from coupling 200 to coupling 200 as needed.
- housing 108 and/or rod 110 contains one or more piezoelectric areas, for example area 166 and/or area 170 that provide ultrasound signals to a biological tissue associated with anchor area 140 and/or 140 A.
- a housing surface 102 and/or receptacle 106 are spaced so that they make contact with anchor area 140 A to provide appropriate monitoring of the birth process.
- housing 108 and/or rod 110 contains a piezoelectric area 170 or 166 that receives ultrasound signals from the biological tissue.
- housing 108 and/or rod 110 contains a conversion coupling that transforms ultrasound signals to radio-frequency (RF) signals.
- RF radio-frequency
- rod 110 is elongated with a wire lead that attaches to a monitoring device and/or an antenna lead that sends signals to a monitoring device.
- anchor ring 100 and/or its leads, will not prematurely displace or block access to the birth canal due to its small size and robust connection.
- Anchor ring 100 for example, does not block the birth canal due to its small size.
- a potential advantage of some embodiments of the present invention is the provision of robust connection of anchor ring 100 to tissue 140 A potentially prevents premature disconnection and allows repeated manipulation of the leads out of the path of the birth canal, without risk that anchor ring 100 will displace and/or remove from tissue 140 A.
- the small size and potentially robust connection of anchor ring 100 and/or other embodiments allows the mother to move freely during the birth process, for example, leaning on the bed and/or walking.
- FIG. 3 shows a cervical anchor caliper 300 with a monitor wire 330 attached to an area of tissue 364 , according to an embodiment of the present invention.
- Anchor areas 342 and 344 are, for example, tissue connection points for sharp ends 322 and 324 respectively adjacent the birth canal of the mother and/or on the fetal head. Additionally or alternatively, anchor areas 342 and 344 are part of a tissue area 364 of another body area, for example, skin and/or a mucosa. By attaching to two points along tissue 364 , anchor caliper 300 potentially provides robust, safe attachment to anchor areas 342 and 344 .
- sharp end 322 and/or 324 are easily manipulated during attachment with one hand pressing upper leg areas 352 and/or 354 .
- the other hand for example, is positioned on wire 330 , remote from tissue 364 and/or external to the birth canal, and aids in stabilizing anchor caliper 300 during attachment.
- a leg 354 is pressed, so that it pivots on a pivot 314 and sharp end 324 moves in a direction 348 into tissue 344 .
- a leg 352 is pressed so that it pivots on pivot 312 and pushes sharp end 322 in a direction 338 into tissue 342 . In this manner sharp end 322 secures to tissue 342 and sharp end 324 secures to tissue 344 so cervical anchor caliper is attached to tissue 364 .
- leg 352 is fixed to crosspiece 318 and does not pivot on pivot 312 and movement of leg 354 alone allows for tissue movement and/or expansion during the birth process.
- fixed sharp end 324 is pressed into anchor tissue 342 with one hand and sharp end 324 is secured in anchor tissue 344 by manipulating wire 330 with the other hand, for example external to the birth canal.
- pivot 314 and/or pivot 312 allow legs 352 and/or 354 to move in response to tissue expansion as occurs, for example, during the birth process. Allowing for tissue expansion prevents undue discomfort to the mother and/or loosening of caliper 300 , caused by expansion, thinning and/or movement of tissue 364 during the birth process.
- expansion means for other embodiments of caliper 300 are included in other alternative embodiments of the present invention to allow comfort to the mother and/or fetus during the birth process.
- a spring 328 creates pressure to move sharp end 324 in a direction 350 , toward anchor area 344 so that release of wire 330 , for example, allows sharp end 324 to attach into anchor area 344 .
- wire 330 is manipulated, for example outside of the birth canal, causing sharp end 322 to move in direction 348 , away from anchor area 342 .
- the other hand is used to stabilize caliper 300 , for example outside the birth canal, holding an extension of leg 352 .
- caliper 300 disengages from tissue areas 342 and 344 with a minimum discomfort to the mother.
- spring 328 incorporates a mechanism that causes spring 328 to move in response to an electric current, for example provided from wire 330 that is configured as a conducting wire.
- an electric current for example provided from wire 330 that is configured as a conducting wire.
- the electricity is used to heat a shape memory material that restraints the spring or forms a retraction element in itself.
- spring 328 pulls sharp end 324 in a direction 360 , away from anchor area 344 so that manipulation of wire 330 causes sharp end 324 to attach into anchor area 344 .
- a holding bar 386 is pressed so that it encompasses legs 352 and 354 above crosspiece 318 maintaining the extended position of sharp end 324 .
- bar 386 is removed from it maintenance position, allowing sharp end 324 to retract in direction 360 by the action of spring 328 , thus ensuring rapid removal of caliper 300 with both hands positioned outside the birth canal.
- anchor caliper 300 attachment and/or removal of anchor caliper 300 , and other exemplary embodiments of alternative anchor embodiments, are easily accomplished, for example, while the operator is wearing sterile gloves and, for example, while the birth canal and or sterile gloves are coated with a lubricant, for example septalon.
- caliper anchor 300 and/or one or more wires 330 are packaged in a sterile package that can be opened, for example, by a non-sterile assistant and/or passed to the operator, for example the obstetrician. Additionally or alternatively, caliper anchor 300 and/or one or more wires 330 can be transported in a tray of sterilizing liquid from which they taken by the operator during the installation procedure.
- a probe wire for example that is not sterile, is attached to the skin of the patient to provide grounding of anchor probe 300 .
- caliper anchor 300 and/or one or more wires 330 are easily deposited in a standard disposal container in the operating theater.
- FIG. 4 shows coupling 200 by which an anchor, for example caliper anchor 300 , attaches to tissue area 364 .
- coupling 200 has an anchor projection 344 ′ and an anchor projection 342 ′ and is attached to tissue 364 with adhesive layer 210 .
- Anchor projection 342 ′ has a passage 372 that is designed to receive sharp end 322 of cervical caliper 300 .
- Anchor projection 344 ′ has a passage 374 that is designed to receive sharp end 324 of cervical anchor caliper 300 .
- Cervical anchor caliper 300 is secured to coupling 200 when sharp ends 322 and 324 are in passages 372 and 374 of anchor projections 342 ′ and 344 ′.
- caliper 300 is assembled with coupling 200 prior to insertion into the birth canal so that attachment of bioadhesive 210 can be accomplished so while holding coupling 200 with, for example, two fingers. Additionally or alternatively, as with other anchor embodiments, a variety of areas of caliper 300 may comprise biodegradable materials and/or SMP's so that caliper 300 weakens, deforms and/or dissolves for easy removal.
- FIG. 5 shows an alternative embodiment of a probe apparatus 500 that allows attachment of a sensor 522 to tissue 506 with a force-operable release mechanism, providing an advantage of easy removal of probe 500 .
- probe 500 comprising a sensor 522 within a housing 516 attached to an area of tissue 506 with an adhesive attachment 512 , according to an embodiment of the present invention.
- Sensor 522 is removed from housing 516 , for example, by pulling a wire 524 , for example, external to the birth canal. Additionally or alternatively, sensor 522 and/or wire 524 are removed from housing 516 by exerting force directly on sensor 522 , for example internal to the birth canal.
- adhesive layer 512 and/or housing 516 are biodegradable and degrade until housing 516 falls away and/or completely dissolves, for example, sometime after completion of the birth process. Additionally or alternatively, adhesive layer 512 and/or housing 516 partially degrade so that housing 516 and/or adhesive 512 weaken below a specific threshold level and are removed with relatively little force, for example following the birth process.
- sensor 522 is held in a sensor compartment 530 of housing 516 by bendable shoulders 532 and 534 . Shoulders 532 and 534 secure sensor 522 in sensor compartment 530 against displacement forces that are typically generated in the birth canal.
- wire 524 and/or probe 550 are pulled in a direction 540 causing sensor 522 to press shoulder 532 in a direction 552 and press shoulder 534 in a direction 554 until shoulder 532 and/or 534 move sufficiently to allow sensor 522 to pull out of compartment 530 .
- removal of sensor 522 from compartment 530 is accomplished while adhesive layer 512 remains attached to tissue 506 without causing shearing separation within tissue 506 .
- the force required to bend shoulder 532 and/or shoulder 534 is between 2 and 3 Newtons, though it could be 4 or more Newtons and/or 0.5 Newtons or less, dependent, for example, on the strength of the connection between bioadhesive layer 512 and tissue 506 and/or the magnitude and/or direction of forces expected during birth.
- a greater force is required in order to separate housing 516 from tissue 506 and/or causing shearing separation within tissue 506 so that housing 516 remains attached to tissue 506 following removal of sensor 522 from compartment 530 .
- Housing 516 is shown adhered in a perpendicular position to tissue 506 . Additionally or alternatively, housing 516 can be designed to be adhered with the visible surface of housing 516 , as seen in FIG. 5, parallel to the surface of tissue 506 .
- housing 516 includes an aperture in its bottom, through which a sensor portion and/or protrusion of sensor 522 can directly contact the tissue.
- This type of design may also be used where housing 516 is attached to the soft tissue using a mechanical means, such as a spike or using methods described herein for other embodiments.
- FIGS. 6 A- 6 D illustrate the operation of a cervical anchor hook 600 that attaches to an anchor area 684 with a handle 634 that operates, for example, external to the birth canal in an exemplary embodiment
- FIG. 6A shows a spring-loaded semi-circular hook 610 within a tunnel 614 in a housing 616 with a sharp end 690 .
- Hook 610 rotates around a pivot hinge 612 that is attached to housing 616 .
- a spring causes cervical hook 600 to press out of tunnel 614 .
- An engagement pin 618 in a pin passage 622 is pressed against hook 610 by a spring 620 , locking hook 610 inside housing 616 , preventing hook 610 from exiting housing 616 .
- Pin 618 prevents movement of hook 610 , for example, either by the friction between pin 618 tip and hook 610 or through articulating with a hook notch 688 .
- engagement pin 618 has been retracted, allowing hook 610 to travel in a curved trajectory 686 , exit housing 616 and pierce through a tissue area 684 .
- Pin 618 presses forward to secure against an elbow 682 to maintain hook 610 attached to tissue 684 .
- the closing spring disengages from hook 610 , once hook 610 is secured.
- FIG. 6C shows an activation mechanism 602 of cervical anchor hook 600 , comprising a tube 630 that houses a cable 628 , attached at one end to pin 618 and at the other end to handle 634 . Pin 618 is retracted within pin passage 622 .
- hook 610 normally remains in tunnel 614 by a spring action that presses hook 610 in a direction 666 (this force may be smaller, for example, than the force exerted by the not shown closing spring).
- this force may be smaller, for example, than the force exerted by the not shown closing spring.
- housing 616 can be manipulated into position on tissue 684 without hook 610 causing irritation to tissue 684 or possibly catching on the fetus.
- manipulation of tube 630 causes hook 610 to travel in direction 686 to effect attachment to tissue 684 .
- pin 618 automatically extends out of housing 616 and presses elbow 682 to maintain hook 610 in the extended position.
- pin 618 is retracted into housing 616 , for example using cable 628 and hook 610 is pressed in direction 666 by spring action.
- handle 634 is attached to grasp area 632 by a seal 652 that prevents inadvertent movement of handle 634 in relation to 632 . Pulling on handle 634 while holding grasp area 632 breaks seal 652 and cable 628 pulls pin 618 into housing 616 .
- hook 610 is spring-loaded to travel in direction 686 , it detaches from tissue 684 .
- pin 618 is pulled into housing 616 using, for example, a rotatable rod connected between handle 634 and pin 618 , allowing retraction of hook 610 .
- the rod is rotated to pull pin 618 into housing 616 and then detached from pin 618 following use, for example by continuing rotation following retraction of pin 618 into housing. Following detachment of the rod from pin 618 , the rod is removed from the birth canal.
- tube 630 and/or grasp area 632 are used to pull housing 616 from the birth canal, allowing removal of cervical anchor hook 600 from the birth canal with both operator's hands outside the birth canal.
- handle 634 is attached to cable 628 and pulling handle 634 in a direction 650 in relation to a grasp area 632 causes cable 628 to retract pin 618 away from hook 610 .
- Spring-loaded hook 610 exits housing 616 and pierces through tissue 684 so that cervical anchor hook 600 is attached to tissue 684 .
- Housing 616 contains a sensor area 624 that monitors the subject through tissue 684 .
- tube 630 has a widening 680 that ends in a washer 678 attached to a pivot control 636 .
- hook 610 is normally held in housing 616 , by stabilizing grasp area 632 with one hand and rotating handle 634 with the other hand in a direction 674 , movement of hook 610 out of tissue 684 is effected.
- rotation of handle 634 in a direction 676 while holding grasp area 632 , causes book 610 to retract into housing 616 .
- FIG. 7 shows an alternative embodiment of a probe apparatus 700 that allows attachment of a probe 720 to tissue with a non-mechanical hookup.
- Probe 700 has a bioadhesive probe attachment 700 with a probe wire 712 that attaches to coupling 200 , according to an embodiment of the present invention.
- probe attachment 700 has a bioadhesive layer 710 that is biodegradable to attach to surface 220 of coupling 200 .
- Probe attachment 700 comprises, for example, silicone or other non-dissolving and/or biodegradable materials specified in relation to the composition of coupling 200 while bioadhesive layer 710 may be similar in composition to that of adhesive layer 210 .
- adhesive layer 710 biodegrades in the same fashion as does adhesive layer 210 , over a period of time and/or through the addition of an agent or energy.
- electromagnetic waves such as heat, ultrasound or electricity
- electromagnetic waves are applied in the vicinity of the flat section to cause dissolution of bioadhesives 710 and/or 210 , probe 720 , wire 712 and/or coupling 200 .
- electromagnetic waves are applied through an independent applicator that is brought near adhesive layer 710 .
- wire 712 provides electric, heat or ultrasound energy that aids in of bioadhesives 710 and/or 210 , probe 720 , wire 712 and/or coupling 200 .
- FIGS. 8B and 8B shows some embodiments, of the many potentially different embodiments, of an anchor embodiment used in attaching a probe, for example, to a fetal scalp.
- these embodiments can be used interchangeably for the fetal head and/or the birth canal.
- the anchors described herein are especially useful for difficult to attach tissue, such as cervical tissue, which distorts, is mucal and/or experiences pressure and distortion during contraction and passage of the fetus and fetal scalp tissue which is wet and/or experiences large shearing forces during delivery, the anchors may be attached to other tissue, such as in the GI tract or in the mouth.
- FIG. 8A shows a straight pin anchor 800 with a housing 804 containing a sensor 808 .
- Housing 804 is attached to a shaft 818 and has a hook 802 that embeds in a target tissue, for example the fetal head.
- a target tissue for example the fetal head.
- a second hand, outside the birth canal is used to guide placement, for example, by holding onto a sheath 828 that covers shaft 818 .
- Sensor 808 sends signals to a monitor, for example, connected with a wire 830 .
- FIG. 8B shows a round pin anchor 810 with a housing 814 containing sensor 808 with a with a round pin 812 .
- housing 814 is placed against a target tissue area and rotated to embed round pin 812 into the tissue.
- housing 814 is attached to shaft 818 .
- shaft 818 By rotating shaft 818 in relation to sheath 828 , round pin 812 rotates and, when held against a target tissue, embeds into the target tissue.
- Rotation of shaft 818 is accomplished, for example, by rotating a grasp area 820 with one hand while stabilizing sheath 828 with the other hand.
- both hands operate, for example, outside the birth canal, with one hand on sheath 828 and/or a shaft stabilizer 832 and the other hand is used to rotate grasp area 820 , causing round pin 812 to rotate out of the tissue area tissue.
- FIG. 8C shows an alternative embodiment of round pin anchor 810 in which sensor 808 sends signals to a monitor through wire 830 and auxiliary wires 806 .
- wire 830 sends an ultrasound signal to provide positioning information and auxiliary wires 806 , for example, transmit additional data from anchor area, for example, providing monitoring of the fetal heartbeat.
- wires 806 and/or 830 are connected to probes that are attached to tissue and provide measurement of EMG, optical devices, for example, for glucose monitoring and/or other skin-attached probes.
- wires 806 and/or 830 are color coded so that the operator is notified of the functions that sensor 808 , for example, provides. Additionally or alternatively, the color coding allows proper attachment to an appropriate monitor. Additionally or alternatively, wires 806 and/or 830 and or round pin anchor 810 are color coded and/or labeled in a manner that notifies the operator of the proper placement, for example on the fetal head and/or on the, os cervix. Additionally or alternatively, wires 830 and/or 806 and or round pin anchor 810 are color-coded and/or labeled in a manner that notifies the operator of proper placement on the skin, for example, for EKG and/or EMG monitoring. Such visual coding, for example, is available on other embodiments of the present invention as well.
- wires 806 and/or 830 are connected to one or more antennae that broadcast signals to a signal receptor that sends the signals to a monitor.
- the different signals are broadcast in different formats so that they do not interfere with one another.
- the positioning sensor provides ultrasound that operates in MHz, providing information on the relationship of the fetal crown to the birth canal.
- the ECG information is, for example, projected in the Hertz band. Additionally or alternatively, both sensors can operate in the MHz band and/or the Hz band, with significant separation of frequency to prevent interference.
- ECG information may be provided, for example, using one or more electrodes 168 (shown in FIG. 1), which may alternatively or additionally used for other sensing purposes.
- FIG. 9 shows a wireless signaler 900 that transmits, for example, RF signals.
- signaler 900 comprises housing 804 in which an incoming ultrasound energy 912 is converted by an RF converter 910 , for example, to electromagnetic RF energy 914 , possibly of same or similar frequency.
- RF energy 914 is then detected by a nearby detector (not shown) and shown, for example, on a display. Further details of an exemplary embodiment are provided for example in the above referenced PCT application file don even date.
- housing 804 contains straight hook 802 and a moveable pin 944 .
- hook 802 is pressed into the tissue.
- Moveable pin 944 is retracted away from hook 802 using shaft 818 and pressed against the tissue.
- Shaft 818 is then moved to cause moveable pin 944 to move toward hook 802 so that the tissue is secured between hook 802 and moveable pin 944 .
- shaft 818 is spring-loaded so that upon release it moves toward hook 802 without further effort.
- sheath 828 is stabilized with one hand.
- Grasp area 820 attached to shaft 818 , is manipulated so that moveable pin 944 moves away from hook 802 so that housing 804 removes from anchor area.
- both hands may be outside the cervix during removal.
- shaft 818 is spring-loaded so that upon release, it moves away from hook 802 .
- grasp area 820 moves shaft 818 forward against the pressure of its spring, while stabilizing sheath 828 .
- a ratchet (for example similar to notches 152 in FIG. 1) is located between shaft 818 and grasp area 820 and manipulated to keep moveable pin 944 in position toward hook 802 during childbirth. Following childbirth, the ratchet mechanism between shaft 818 and grasp area 820 is released so that moveable pin 944 retracts away from hook 802 and housing 804 is easily removed from the target tissue.
- FIG. 10 shows ultrasound sensor 1000 , for example that sends and receives ultrasound signals.
- sensor 1000 can be used, for example, in housing 804 .
- a small piezoelectric transducer 1048 has two active faces 1046 that are soldered, for example, to a coaxial cable 830 A. Additionally or alternatively, a twisted pair wire 830 A may be used.
- FIGS. 11 A- 11 C show a probe 1100 in a tissue 1184 with an expanding anchor tip 1102 that is adapted for use in soft tissue, for example adjacent the birth canal and that, for example, deflates and/or biodegrades following use.
- anchor tip 1102 is shown in the pre-expanded state following being pressed into tissue 1184 .
- anchor tip 1102 exhibits rigidity sufficient to be pressed into soft tissue 1184 by moving probe 1100 toward tissue 1184 .
- an anchor delivery system provides a rigid deployer guide that, for example, surrounds anchor tip 1102 to aid in pressing it into tissue 1184 .
- FIG. 11B shows anchor tip 1102 expanded causing side points 1104 and 1106 to press laterally into tissue 1184 .
- Expansion for anchor tip 1102 is through the introduction of a fluid, for example, sterile saline and/or inert gas.
- anchor tip 1102 can anchor in tissue 1184 with a variety of alternative shapes, for example a sphere or single side point 1104 . Removal of anchor tip 1102 , for example, is accomplished by deflating tip 1102 .
- anchor tip 1102 is attached to a tube 1120 that extends outside the cervix and expansion and/or shrinkage is accomplished, for example, by pressing an expansion gasket to press a fluid into anchor tip 1102 .
- a stop 1124 for example on tube 1120 and/or the expansion gasket, maintains the fluid under pressure during the expansion period. Shrinkage and/or deflation, is accomplished by releasing stop 1124 so the fluid exits anchor tip 1102 .
- FIG. 11C shows a dissolvable embodiment of expandable anchor tip 1102 in which a stop 1124 A is contained on probe 1100 and tube 1120 has been removed past stop 1124 , leaving tube 1120 within probe 1100 .
- tube 1120 and/or gasket 1124 are external to probe 1100 , for example, as part of an antenna housing.
- expand anchor tip 1102 begins to deform so that side points 1104 and 1106 loose their shape and probe 1100 can be removed from tissue 1184 .
- the walls of anchor tip 1102 become thinner after a base period of time so tip 1102 deforms to gradually release the fluid it contains.
- expandable anchor 1102 has an internal expansion mechanism, that expands side points 1104 and/or 1106 automatically in response to an activation stimulus.
- An activation stimulus for example, comprises increased pressure during insertion that cause an internal fluid reservoir to break and fill anchor 1102 with pressurized fluid.
- an activation stimulus comprises application of electromagnetic waves or a catalytic agent that causes a fluid reservoir to break.
- FIGS. 12A and 12B show an alternative embodiment of a probe 1200 that uses SMP technology in attaching to and removing from tissue.
- FIGS. 12A and 12B show probe 1200 made of, for example, shape memory polymers (SMP's) as identified in “Shape Shifters” in Scientific American , May 2001, noted above.
- SMP shape memory polymers
- An SMP is capable of changing shape in response to a temperature increase. With the addition of heat, for example from the body, an SMP deforms into a temporary configuration. Upon removal of the temperature increase an SMP will revert to its former shape.
- An SMP can be formulated to deform at a wide variety of temperatures.
- SMP's made of polyurethane recover their shape as the temperature drops to between 30 and 70 degrees Celsius.
- the temperature at which the change occurs is dependent upon the formulation of the polyurethane-based SMP.
- SMP's for example, are biocompatible and capable of 400 percent shape recovery.
- springs 1220 and 1222 are made of an SMP and anchored to anchors 1250 and/or 1252 at one end and to anchors 1230 and 1232 at the other end.
- SMP springs 1220 and 1222 After a base period of time, for example encompassing the delivery period, SMP springs 1220 and 1222 , reach a deforming temperature and deform into a shape, as shown in FIG. 12B that causes retraction of anchors 1240 and/or 1242 into probe 1200 so that it can be removed from a tissue 1210 .
- a biodegradable polymer wedge 1260 that biodegrades as a result of, for example hydrolysis in the wet tissue environment is located adjacent to anchor 1240 and a biodegradable polymer wedge 1262 is located adjacent to anchor 1242 .
- Polymer wedges 1260 and 1262 dissolve over a base period of time, for example 12-24 hours and/or a period that encompasses, for example, a typical birth process.
- SMP springs 1220 and 1222 change, for example, within several hours and exert force to pull anchors 1240 and 1242 within probe 1200 , they are prevented from retracting due to the interposition of wedges 1260 and 1262 .
- SMP springs 1220 and 1222 pull anchors 1240 and 1242 into probe 1200 .
- FIG. 13 shows a probe deployer apparatus 1300 that can be utilized in a sterile field, according to an embodiment of the present invention.
- Probe deployer 1300 has a well 1340 or other receptacle in which probe 1200 is held. Probe 1200 is shown with a coiled wire extension 1360 and anchor tips 1230 and 1232 in the retracted position.
- Probe deployer 1300 has a handle 1326 and a lever 1310 that ends in a trigger 1320 .
- Lever 1310 pivots on a pivot 1328 so that as trigger 1320 is pressed in a direction 1312 , lever 1310 moves in a direction 1346 .
- a prong 1322 moves against anchor tips 1230 and 1232 to cause them to exit probe 1200 and anchor in tissue 1210 .
- lever 1310 moves in direction 1346 , pressing probe 1200 out of well 1340 so that probe 1200 easily separates from deployer apparatus 1300 following implantation into the tissue, for example, adjacent the birth canal.
- deployer apparatus 1300 installs probe anchor 1200 into tissue 1210 , for example of the birth canal, in a single action and/or does not require further manual inspection. Additionally or alternatively, deployer apparatus 1300 is disposable following a single use. Additionally or alternatively, deployer apparatus 1300 can be used multiple times and sterilized between uses.
- the entire probe deployer apparatus 1300 is sterile and handled by an operator with sterile gloved hands. Additionally or alternatively, handle 1326 is not sterile, being handled by an operator wearing non-sterile gloves while, for example, the area of deployer 1300 near tissue 1210 is sterile. Additionally or alternatively, the parts of the deployer apparatus cartridge and/or anchor that come into contact with the tissue of the birth canal area are sterile.
- one or more probe anchors 1200 are contained in a sterile cartridge that fits into the deployer apparatus 1300 and advance forward to deploy in tissue, for example, with a spring mechanism so that one probe 1200 is always ready to be deployed until there are no further probe anchors 1200 .
- the deployer apparatus may be adapted for use with other anchors, for example as described herein, optionally, including a release mechanism suitable for the particular anchoring method used, for example, a pin retraction for the embodiment of FIG. 6.
- the deployer apparatus includes a control for attaching to the anchor release mechanism, for assistance in removal of the device, for example, a pulley to pull on the cable (in FIG. 6).
- the anchors are provided on a conveyer line, so that when one is deployed, the next comes into position.
- a spring is used to advance the anchors.
- Mechanisms similar to those used in surgical clip deployers may be used as well known in the rat.
- deployer apparatus 1300 is equipped with a first positioning prong 1320 and/or a second positioning prong that aid in centering probe 1200 automatically on an external surface of the cervical os.
- positioning prongs 1320 and/or 1322 are radiopaque to aid in proper placement of probe 1200 on an external surface of the cervical os so that the operator can readily assess the position of probe 1200 using a radiographic imager suitable for imaging during deployment.
- probe 1200 remains in tissue 1210 for a base period of time, following which it deforms, dissolves and/or is modified in shape so that it can be easily removed from tissue 1210 , for example, by pulling on wire extension 1360 .
- FIGS. 14 A- 14 E show several embodiments of different probe anchor tip designs, according to an embodiment of the present invention that optionally are deliverable with probe delivery apparatus 1300 , according to an embodiment of the present invention.
- delivery apparatus 1300 delivers a wide variety of probe anchors including those shown in FIGS. 14 a - 14 E, the various embodiments demonstrated as exemplary embodiments of the present invention. Additionally or alternatively, as can be readily appreciated, delivery apparatus 1300 can be modified in various ways in order to deliver any number of probes with designs other than those specifically shown.
- FIG. 14A shows anchor tip 1102 attached to a probe base 1410 that is cylindrical, for example allowing it to interface with well 1340 .
- anchor tip 1102 is in the deflated position as shown in FIG. 11A and it is delivered to tissue 1184 with delivery apparatus 1300 .
- prong 1322 presses against cylinder 1410 and causes the release of a pressurized fluid to expand anchor tip 1102 .
- probe delivery apparatus 1300 is used to pierce probe 1410 and release the pressure so that tip 1102 deflates.
- FIG. 14B shows a modification of round pin 812 that demonstrates more circular revolutions than round pin 812 pictured in FIG. 8B.
- prong 1322 rotates as it moves in direction 1346 .
- a probe 1400 B for example, is delivered to an anchor area and circular tip 810 rotates into the anchor area as prong 1322 presses on it in direction 1346 , securing probe 1400 B to the tissue.
- delivery apparatus 1300 is attached to probe 1410 and, by causing prong 1322 to move in direction 1348 , it reverses its rotation to cause round pin 812 to rotate opposite to its rotation during implantation, causing removal of probe 1400 B.
- FIG. 14C shows a probe 1400 C with tip 1102 coupled with a pancake-shaped probe 1420 .
- Pancake probe 1420 may have use where a low profile is important, for example in taking measurement within the pleural sac around the heart.
- FIG. 14D shows probe 1400 D with flexible tips 1130 that spread away from each other prior to deployment and contract toward each other to secure to a tissue.
- prong 1322 presses into a passage 1338 of probe 1400 D and presses against scissor ends 1436 , causing the spreading of flexible tips 1130 away from each other. Release of prong 1322 , for example, allow tips 1430 to contract toward each other and attach to an anchor area.
- removal of probe 1400 D is effected by pressing prong 1322 into scissor ends 1436 , causing them to expand away from each other so that probe 1400 D can be removed from the anchor area.
- FIG. 14E shows probe 1400 E with a pincer arm 1440 that has a slope edge 1452 .
- Prong 1322 for example, is pressed into a passage 1450 until its tip presses slope edge 1452 , causing pincer arm 1440 to spread from a stationary arm 1442 as it pivots on a spring pivot 1454 . Removal of prong 1322 from slope edge 1452 , for example, allows pincer arm 1440 to move toward stationary arm 1442 and secure into an anchor area.
- Removal of probe 1400 E is effected by pressing prong 1322 into slope edge 1452 , causing pincer arm 1440 to spread from stationary arm 1442 so that probe 1400 D can be removed from the anchor area.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Computer Networks & Wireless Communication (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Physiology (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Surgical Instruments (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Radar Systems Or Details Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29556901P | 2001-06-05 | 2001-06-05 | |
US29557301P | 2001-06-12 | 2001-06-12 | |
US30978301P | 2001-08-06 | 2001-08-06 | |
US33867101P | 2001-12-11 | 2001-12-11 | |
PCT/IL2002/000441 WO2002098272A2 (fr) | 2001-06-05 | 2002-06-05 | Element d'ancrage pour sonde |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040153008A1 true US20040153008A1 (en) | 2004-08-05 |
Family
ID=31999542
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/479,826 Expired - Fee Related US7207941B2 (en) | 2001-06-05 | 2002-06-05 | Birth monitoring system |
US10/480,008 Abandoned US20040153008A1 (en) | 2001-06-05 | 2002-06-05 | Probe anchor |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/479,826 Expired - Fee Related US7207941B2 (en) | 2001-06-05 | 2002-06-05 | Birth monitoring system |
Country Status (6)
Country | Link |
---|---|
US (2) | US7207941B2 (fr) |
EP (2) | EP1420697A4 (fr) |
JP (2) | JP2004535861A (fr) |
AU (2) | AU2002309238A1 (fr) |
IL (2) | IL159208A0 (fr) |
WO (2) | WO2002098272A2 (fr) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050143624A1 (en) * | 2003-12-31 | 2005-06-30 | Given Imaging Ltd. | Immobilizable in-vivo imager with moveable focusing mechanism |
US20070270651A1 (en) * | 2006-05-19 | 2007-11-22 | Zvika Gilad | Device and method for illuminating an in vivo site |
US20090292246A1 (en) * | 2008-05-20 | 2009-11-26 | Slate John B | Cassette for a hidden injection needle |
WO2009143255A1 (fr) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Système d’auto-injection |
US20100022955A1 (en) * | 2008-07-23 | 2010-01-28 | Slate John B | System and method for an injection using a syringe needle |
US20100137686A1 (en) * | 2002-04-25 | 2010-06-03 | Gavriel Meron | Device and method for orienting a device in vivo |
US7753842B2 (en) | 2001-06-28 | 2010-07-13 | Given Imaging Ltd. | In vivo imaging device with a small cross sectional area |
US20110004281A1 (en) * | 2009-07-03 | 2011-01-06 | Jones Robert E | Implantable anchor with locking cam |
US7946979B2 (en) * | 2002-12-26 | 2011-05-24 | Given Imaging, Ltd. | Immobilizable in vivo sensing device |
WO2011086481A1 (fr) | 2010-01-14 | 2011-07-21 | Koninklijke Philips Electronics N.V. | Capteur déterminant un paramètre physique ou physiologique |
US8206280B2 (en) | 2007-11-13 | 2012-06-26 | C. R. Bard, Inc. | Adjustable tissue support member |
US8257394B2 (en) | 2004-05-07 | 2012-09-04 | Usgi Medical, Inc. | Apparatus and methods for positioning and securing anchors |
US20120253144A1 (en) * | 2011-03-29 | 2012-10-04 | Olympus Corporation | Sensor |
US8480559B2 (en) | 2006-09-13 | 2013-07-09 | C. R. Bard, Inc. | Urethral support system |
US8845512B2 (en) | 2005-11-14 | 2014-09-30 | C. R. Bard, Inc. | Sling anchor system |
US8870916B2 (en) | 2006-07-07 | 2014-10-28 | USGI Medical, Inc | Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use |
US8992547B2 (en) | 2012-03-21 | 2015-03-31 | Ethicon Endo-Surgery, Inc. | Methods and devices for creating tissue plications |
US20150164549A1 (en) * | 2012-08-27 | 2015-06-18 | Terumo Kabushiki Kaisha | Medical tube, medical tube assembly and puncture needle |
US9113879B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9113867B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
USD829890S1 (en) | 2012-04-20 | 2018-10-02 | Amgen Inc. | Injection device |
US10092706B2 (en) | 2011-04-20 | 2018-10-09 | Amgen Inc. | Autoinjector apparatus |
US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
WO2019244159A1 (fr) | 2018-06-21 | 2019-12-26 | Pregnantech Ltd. | Retardement d'une naissance avant terme |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
CN113164111A (zh) * | 2018-10-02 | 2021-07-23 | 生命轨迹私人有限公司 | 用于监测胎儿中的分析物浓度的装置、系统和方法 |
WO2021209873A1 (fr) * | 2020-04-12 | 2021-10-21 | Uc-Care Ltd | Procédé et système de guidage d'aiguille trans-périnéale à base de capteur |
US20220110552A1 (en) * | 2019-10-16 | 2022-04-14 | James Robert Balman | Apparatus and method for determining physiological parameters of an infant in-utero |
US20230190232A1 (en) * | 2016-03-21 | 2023-06-22 | Isono Health, Inc. | Wearable ultrasound system and method |
US11712248B2 (en) | 2014-04-14 | 2023-08-01 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Delaying pre-term birth |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6669653B2 (en) * | 1997-05-05 | 2003-12-30 | Trig Medical Ltd. | Method and apparatus for monitoring the progress of labor |
JP2004535861A (ja) * | 2001-06-05 | 2004-12-02 | バーネフ リミテッド | 出産モニタリングシステム |
CA2447861A1 (fr) * | 2002-11-01 | 2004-05-01 | Lms Medical Systems Ltd. | Methode et appareil de determination des episodes particuliers de la frequence cardiaque |
EP1486217B1 (fr) | 2003-06-12 | 2010-05-12 | Terumo Kabushiki Kaisha | Système à pompe cardiaque artificielle et apparail de commande |
US8682423B2 (en) | 2003-07-11 | 2014-03-25 | Ob Tools Ltd. | Three-dimensional monitoring of myographic activity |
US7447542B2 (en) * | 2003-07-11 | 2008-11-04 | Ob Tools Ltd. | Three-dimensional monitoring of myographic activity |
DE10336736B4 (de) * | 2003-08-11 | 2005-07-21 | Siemens Ag | Vorrichtung und Methode zur Aufnahme von Bildinformationen zum Erstellen eines dreidimensionalen Bildes |
EP1660911A1 (fr) * | 2003-08-20 | 2006-05-31 | Cornell Research Foundation, Inc. | Dispositif et procede de suivi de position d'un appareil de telemetrie locale dans un environnement fluidique ou gazeux |
US7049965B2 (en) * | 2003-10-02 | 2006-05-23 | General Electric Company | Surveillance systems and methods |
US7645292B2 (en) | 2003-10-27 | 2010-01-12 | Boston Scientific Scimed, Inc. | Vaso-occlusive devices with in-situ stiffening elements |
US20060058615A1 (en) * | 2003-11-14 | 2006-03-16 | Southern Illinois University | Method and system for facilitating surgery |
DE102004014694A1 (de) * | 2004-03-25 | 2005-10-27 | Universität Bremen | System und in ein Gewebe von Lebewesen implantierbare Vorrichtung zur Erfassung und Beeinflussung von elektrischer Bio-Aktivität |
JP2007532169A (ja) * | 2004-04-07 | 2007-11-15 | バーネフ リミテッド | 出産医療用監視装置 |
US7552699B2 (en) * | 2004-10-20 | 2009-06-30 | Radio Systems Corporation | Transponding of a signal using the same antenna |
US7414534B1 (en) * | 2004-11-09 | 2008-08-19 | Pacesetter, Inc. | Method and apparatus for monitoring ingestion of medications using an implantable medical device |
JP4716279B2 (ja) * | 2005-01-31 | 2011-07-06 | セイコーインスツル株式会社 | 血液粘性測定装置 |
PL1868498T3 (pl) * | 2005-03-29 | 2013-09-30 | Martin Roche | Czujnik do wykrywania parametrów ciała oraz sposób wykrywania parametrów ciała |
US8636676B2 (en) * | 2005-06-07 | 2014-01-28 | Perigen, Inc | Method and apparatus for providing information related to labor progress for an obstetrics patient |
US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
US7811239B2 (en) | 2005-12-29 | 2010-10-12 | Intrapartum, Llc | Cervical dilation measurement apparatus |
US7713216B2 (en) * | 2006-04-10 | 2010-05-11 | Intrapartum, Llc | Method for cervical dilation and/or measurement |
US7527601B2 (en) * | 2005-12-29 | 2009-05-05 | Intrapartum Ventures, Llc | Cervimeter |
WO2007117478A2 (fr) * | 2006-04-05 | 2007-10-18 | Health Beacons, Inc. | processus chirurgicaux |
US9805164B2 (en) * | 2006-05-01 | 2017-10-31 | Perigen, Inc. | Method and apparatus for providing contraction information during labour |
US10134490B2 (en) | 2006-05-01 | 2018-11-20 | Perigen, Inc. | Method and system for monitoring labour progression for an obstetrics patient |
DE102006029122A1 (de) * | 2006-06-22 | 2007-12-27 | Amedo Gmbh | System zur Bestimmung der Position eines medizinischen Instrumentes |
RU2009116246A (ru) * | 2006-09-29 | 2010-11-10 | Конинклейке Филипс Электроникс Н.В. (Nl) | Способ и устройство для ультразвукового исследования, оставляющее руки свободными |
US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
WO2008088898A1 (fr) * | 2007-01-19 | 2008-07-24 | Sierra Scientific Instruments, Inc. | Dispositif de mesure physiologique gastro-intestinale à microdistance |
WO2008117834A1 (fr) * | 2007-03-27 | 2008-10-02 | Shinshu University | Système de contrôle de mise bas |
JP4934513B2 (ja) * | 2007-06-08 | 2012-05-16 | 株式会社日立メディコ | 超音波撮像装置 |
US20090093716A1 (en) * | 2007-10-04 | 2009-04-09 | General Electric Company | Method and apparatus for evaluation of labor with ultrasound |
US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
US9636031B2 (en) | 2007-11-26 | 2017-05-02 | C.R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
CN103750858B (zh) | 2007-11-26 | 2017-04-12 | C·R·巴德股份有限公司 | 用于脉管系统内的导管放置的集成系统 |
US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
US9456766B2 (en) | 2007-11-26 | 2016-10-04 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
CA2707312C (fr) * | 2007-12-10 | 2016-06-07 | Lms Medical Systems Ltd. | Procede et appareil d'information sur les contractions pendant le travail |
US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
US8603013B2 (en) * | 2008-03-13 | 2013-12-10 | Kci Licensing, Inc. | Pressure switches, transmitters, systems, and methods for monitoring a pressure at a tissue site |
US9526407B2 (en) * | 2008-04-25 | 2016-12-27 | Karl Storz Imaging, Inc. | Wirelessly powered medical devices and instruments |
US9603512B2 (en) * | 2008-04-25 | 2017-03-28 | Karl Storz Imaging, Inc. | Wirelessly powered medical devices and instruments |
WO2010004564A2 (fr) * | 2008-07-11 | 2010-01-14 | Barnev Ltd. | Procédé et système permettant de surveiller des contractions et/ou un processus de naissance et/ou de progression de naissance et/ou la position d’un fœtus |
EP2328475B1 (fr) * | 2008-08-18 | 2016-01-06 | Glenveigh Medical, LLC | Dispositif de mesure de dilatation cervicale |
US9901714B2 (en) | 2008-08-22 | 2018-02-27 | C. R. Bard, Inc. | Catheter assembly including ECG sensor and magnetic assemblies |
US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
US8292831B2 (en) * | 2009-01-16 | 2012-10-23 | Ob Technologies, Llc | Method of measuring fetal head orientation, position, and velocity and providing feedback to mother and doctor |
US8973584B2 (en) | 2009-02-13 | 2015-03-10 | Health Beacons, Inc. | Method and apparatus for locating passive integrated transponder tags |
CZ2009127A3 (cs) * | 2009-03-02 | 2010-09-15 | Medetron S.R.O. | Zpusob vcasného rozpoznání rizika predcasného porodu spocívající ve sledování deložní aktivity na základe vyhodnocování deložních kontrakcí a zapojení k provádení zpusobu |
US8172776B2 (en) * | 2009-06-09 | 2012-05-08 | Browne Paul C | Systems and methods for detecting labor conditions via electromagnetic field disturbances |
US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
EP3542713A1 (fr) | 2009-06-12 | 2019-09-25 | Bard Access Systems, Inc. | Adaptateur pour un dispositif de positionnement d'une pointe de cathéter |
WO2011019760A2 (fr) | 2009-08-10 | 2011-02-17 | Romedex International Srl | Dispositifs et procédés pour électrographie endovasculaire |
US20110190582A1 (en) * | 2009-09-28 | 2011-08-04 | Bennett James D | Intravaginal optics targeting system |
US8460217B2 (en) * | 2009-09-29 | 2013-06-11 | Khashayar Shakiba | Electronic pelvic organ prolapse quantification system |
US11103213B2 (en) | 2009-10-08 | 2021-08-31 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
CN102821679B (zh) | 2010-02-02 | 2016-04-27 | C·R·巴德股份有限公司 | 用于导管导航和末端定位的装置和方法 |
CA2800813C (fr) | 2010-05-28 | 2019-10-29 | C.R. Bard, Inc. | Appareil convenant a une utilisation avec un systeme de guidage d'insertion d'aiguille |
WO2012021542A2 (fr) | 2010-08-09 | 2012-02-16 | C.R. Bard, Inc. | Structures de support et de capuchon pour tête de sonde à ultrasons |
EP2605699A4 (fr) | 2010-08-20 | 2015-01-07 | Bard Inc C R | Reconfirmation de positionnement de bout de cathéter assistée par ecg |
CN103189009B (zh) | 2010-10-29 | 2016-09-07 | C·R·巴德股份有限公司 | 医疗设备的生物阻抗辅助放置 |
US9168022B2 (en) * | 2011-01-07 | 2015-10-27 | General Electric Company | Abdominal sonar system and apparatus |
US9597055B2 (en) * | 2011-01-07 | 2017-03-21 | General Electric Company | Fetal scalp doppler device and system |
CA2835890A1 (fr) | 2011-07-06 | 2013-01-10 | C.R. Bard, Inc. | Determination et etalonnage de longueur d'aiguille pour un systeme de guidage d'introduction |
USD724745S1 (en) | 2011-08-09 | 2015-03-17 | C. R. Bard, Inc. | Cap for an ultrasound probe |
USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
US9443061B2 (en) | 2011-08-16 | 2016-09-13 | Elwha Llc | Devices and methods for recording information on a subject's body |
US20140231520A1 (en) * | 2011-08-16 | 2014-08-21 | Elwha Llc | Biocompatible and ultrasound-differentiable micro-objects suitable for implantation in a vertebrate subject |
US9772270B2 (en) | 2011-08-16 | 2017-09-26 | Elwha Llc | Devices and methods for recording information on a subject's body |
WO2013070775A1 (fr) | 2011-11-07 | 2013-05-16 | C.R. Bard, Inc | Insert à base d'hydrogel renforcé pour ultrasons |
SG191435A1 (en) * | 2011-12-13 | 2013-07-31 | Smart Communications Inc | System and method for transmitting partograph information and analysing the same |
CN103371852B (zh) * | 2012-04-18 | 2015-11-25 | 广州贝护佳医疗科技有限公司 | 一种远程无线胎儿监护系统 |
CN104837413B (zh) | 2012-06-15 | 2018-09-11 | C·R·巴德股份有限公司 | 检测超声探测器上可移除帽的装置及方法 |
US8939153B1 (en) | 2013-03-15 | 2015-01-27 | Health Beacons, Inc. | Transponder strings |
EP3062683B1 (fr) * | 2013-10-30 | 2017-05-24 | Koninklijke Philips N.V. | Système et procédé de surveillance de grossesse |
US9839372B2 (en) | 2014-02-06 | 2017-12-12 | C. R. Bard, Inc. | Systems and methods for guidance and placement of an intravascular device |
US10478151B2 (en) | 2014-08-12 | 2019-11-19 | General Electric Company | System and method for automated monitoring of fetal head descent during labor |
US10188310B2 (en) | 2014-08-24 | 2019-01-29 | Health Beacons, Inc. | Probe for determining magnetic marker locations |
US10368833B2 (en) | 2014-09-12 | 2019-08-06 | General Electric Company | Method and system for fetal visualization by computing and displaying an ultrasound measurement and graphical model |
KR102356719B1 (ko) * | 2014-12-01 | 2022-01-27 | 삼성메디슨 주식회사 | 초음파 영상 장치 및 그 동작 방법 |
US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
US10349890B2 (en) | 2015-06-26 | 2019-07-16 | C. R. Bard, Inc. | Connector interface for ECG-based catheter positioning system |
US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
US11529194B2 (en) * | 2016-03-31 | 2022-12-20 | Koninklijke Philips N.V. | Wireless position determination |
US11452004B2 (en) | 2016-11-08 | 2022-09-20 | Koninklijke Philips N.V. | Method for wireless data transmission range extension |
EP3551082B1 (fr) * | 2016-12-12 | 2020-09-09 | Koninklijke Philips N.V. | Capteurs passifs et actifs pour suivi ultrasonore |
WO2018162361A1 (fr) * | 2017-03-09 | 2018-09-13 | Koninklijke Philips N.V. | Circuit de capteur et analyseur de signal pour mesurer une propriété intracorporelle |
EP3406186A1 (fr) * | 2017-05-26 | 2018-11-28 | Koninklijke Philips N.V. | Circuit de capteur et analyseur de signal servant à mesurer une propriété intracorporelle |
US20190065489A1 (en) * | 2017-08-24 | 2019-02-28 | General Electric Company | Method and system for assigning, routing, and unassigning data flows of ultrasound patch probes |
GB201721863D0 (en) * | 2017-12-24 | 2018-02-07 | Vivoplex Group Ltd | Monitoring system |
US11717257B2 (en) * | 2018-01-22 | 2023-08-08 | General Electric Company | Fetal ultrasound monitoring method and system |
WO2020081373A1 (fr) | 2018-10-16 | 2020-04-23 | Bard Access Systems, Inc. | Systèmes de connexion équipés de sécurité et leurs procédés d'établissement de connexions électriques |
US11266376B2 (en) * | 2020-06-19 | 2022-03-08 | Ultrasound Ai Inc. | Premature birth prediction |
Citations (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2924220A (en) * | 1959-02-20 | 1960-02-09 | Micsky Lajos I Von | Cervicometer |
US3090862A (en) * | 1959-08-31 | 1963-05-21 | Berk Sigmund | Radioactive temperature indicating devices |
US3533274A (en) * | 1966-03-21 | 1970-10-13 | Peter Harold Howard Bishop | Apparatus and method for determining thermal conductivity |
US3768459A (en) * | 1971-06-28 | 1973-10-30 | Utah Res & Dev Co Inc | Cervical dilation measuring device |
US3811443A (en) * | 1971-01-22 | 1974-05-21 | Agrophysic Inc | Method and apparatus for artificial insemination |
US4141345A (en) * | 1976-01-08 | 1979-02-27 | National Research Development Corporation | Cervical dilation measurement instruments |
US4151831A (en) * | 1976-11-15 | 1979-05-01 | Safetime Monitors, Inc. | Fertility indicator |
US4151835A (en) * | 1978-03-08 | 1979-05-01 | John Copeland | Foetal scalp electrodes |
US4160971A (en) * | 1975-05-02 | 1979-07-10 | National Research Development Corporation | Transponders |
US4248089A (en) * | 1975-09-08 | 1981-02-03 | Ferdinand Heinmets | Temperature measuring |
US4294258A (en) * | 1978-03-23 | 1981-10-13 | Agence Nationale De Valorisation De La Recherche (Anvar) | Measuring head enabling the production of physiological measurement signals designed to be positioned on or in corporeal parts |
US4345470A (en) * | 1978-09-28 | 1982-08-24 | Akzona Incorporated | All plastic disposable thermometer |
US4475560A (en) * | 1982-04-29 | 1984-10-09 | Cordis Corporation | Temporary pacing lead assembly |
US4488558A (en) * | 1981-06-16 | 1984-12-18 | Innova Wiener Innovationsgesellschaft M.B.H. | Birth monitor |
US4543965A (en) * | 1982-06-13 | 1985-10-01 | Ben-Gurion University Of The Negev Research And Development Authority | Method and device for measuring intrauterine pressure |
US4619301A (en) * | 1982-12-23 | 1986-10-28 | Agency Of Industrial Science And Technology | Spike tire |
US4677967A (en) * | 1984-11-01 | 1987-07-07 | New Mexico State University Foundation | Intravaginal anchor |
US4686996A (en) * | 1985-12-24 | 1987-08-18 | Paul Ulbrich | Electrode assembly for sensing heart activity |
US4776346A (en) * | 1984-02-10 | 1988-10-11 | Dan Beraha | Biopsy instrument |
US4836208A (en) * | 1985-12-24 | 1989-06-06 | American Home Products Corporation (Del.) | Electrode assembly for sensing heart activity |
US4867177A (en) * | 1987-05-15 | 1989-09-19 | Gynex, Inc. | Vaginal drape, insertion unit and kit |
US4945305A (en) * | 1986-10-09 | 1990-07-31 | Ascension Technology Corporation | Device for quantitatively measuring the relative position and orientation of two bodies in the presence of metals utilizing direct current magnetic fields |
US4990161A (en) * | 1984-03-16 | 1991-02-05 | Kampner Stanley L | Implant with resorbable stem |
US5137028A (en) * | 1989-10-18 | 1992-08-11 | Nishimoto, Co., Ltd. | Clinical thermometer for women |
US5169914A (en) * | 1988-05-03 | 1992-12-08 | Edison Polymer Innovation Corporation | Uniform molecular weight polymers |
US5211165A (en) * | 1991-09-03 | 1993-05-18 | General Electric Company | Tracking system to follow the position and orientation of a device with radiofrequency field gradients |
US5222485A (en) * | 1990-09-17 | 1993-06-29 | Ravinder Jerath | Ultrasound labor monitoring method and apparatus |
US5259395A (en) * | 1992-01-15 | 1993-11-09 | Siemens Pacesetter, Inc. | Pacemaker lead with extendable retractable lockable fixing helix |
US5284141A (en) * | 1992-07-31 | 1994-02-08 | Eibling David L | Electrode emplacement apparatus for amniotomy and fetal monitoring and method of use |
US5353354A (en) * | 1990-11-22 | 1994-10-04 | Advanced Technology Laboratories, Inc. | Acquisition and display of ultrasonic images from sequentially oriented image planes |
US5388579A (en) * | 1993-09-23 | 1995-02-14 | Graphic Controls Corporation | Fetal electrode product with channeled drive mechanism and improved torque characteristics |
US5423323A (en) * | 1993-08-30 | 1995-06-13 | Rocky Mountain Research, Inc. | System for calculating compliance and cardiac hemodynamic parameters |
US5438996A (en) * | 1994-10-12 | 1995-08-08 | Triton Technology, Inc. | Ambulatory, ultrasonic transit time, real-time, cervical effacement and dilatation monitor with disposable probes |
US5492119A (en) * | 1993-12-22 | 1996-02-20 | Heart Rhythm Technologies, Inc. | Catheter tip stabilizing apparatus |
US5497771A (en) * | 1993-04-02 | 1996-03-12 | Mipm Mammendorfer Institut Fuer Physik Und Medizin Gmbh | Apparatus for measuring the oxygen saturation of fetuses during childbirth |
US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5515853A (en) * | 1995-03-28 | 1996-05-14 | Sonometrics Corporation | Three-dimensional digital ultrasound tracking system |
US5538005A (en) * | 1993-06-25 | 1996-07-23 | The Regents Of The University Of California | B'method for monitoring fetal characteristics by radiotelemetric transmission |
US5645062A (en) * | 1993-02-15 | 1997-07-08 | Anderson; John Mccune | Biomedical electrode device |
US5671736A (en) * | 1995-10-17 | 1997-09-30 | Graphic Controls Corporation | Fetal electrode product with easy-to-handle connector |
US5680859A (en) * | 1995-10-11 | 1997-10-28 | Graphic Controls Corporation | Integrated introducer and drive rod positioning system for a fetal spiral electrode |
US5713371A (en) * | 1995-07-07 | 1998-02-03 | Sherman; Dani | Method of monitoring cervical dilatation during labor, and ultrasound transducer particularly useful in such method |
US5727547A (en) * | 1996-09-04 | 1998-03-17 | Nellcor Puritan Bennett Incorporated | Presenting part fetal oximeter sensor with securing mechanism for providing tension to scalp attachment |
US5807271A (en) * | 1997-04-14 | 1998-09-15 | Tayebi; Sean | Fetal heartbeat and uterine contraction |
US5807281A (en) * | 1996-10-01 | 1998-09-15 | Welch; Robert A. | Cervical ring to detect labor |
US5817035A (en) * | 1994-11-24 | 1998-10-06 | The Institute Of Respiratory Medicine Ltd. | Biophysical foetal monitor |
US5816707A (en) * | 1994-05-06 | 1998-10-06 | Minnesota Mining And Manufacturing Company | Reversible chemical thermometer |
US5817108A (en) * | 1995-06-07 | 1998-10-06 | Medtronic, Inc. | Device and method for suturing wound |
US5829438A (en) * | 1994-10-12 | 1998-11-03 | Gibbs; David L. | System and method for the infusing of tocolytic drugs in response to the onset of premature labor detected by ultrasonic monitoring of the dilatation and/or effacement of the cervix os |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5833622A (en) * | 1994-04-04 | 1998-11-10 | Graphic Controls Corporation | Non-invasive fetal probe having improved mechanical and electrical properties |
US5843076A (en) * | 1995-06-12 | 1998-12-01 | Cordis Webster, Inc. | Catheter with an electromagnetic guidance sensor |
US5851188A (en) * | 1994-10-12 | 1998-12-22 | Bullard; Kelli M. | Device for holding medical instrumentation sensors at and upon the cervix os of a human female, particularly for holding the ultrasonic transducers of an ultrasonic transit time, real-time, cervical effacement and dilatation monitor |
US5851179A (en) * | 1996-10-10 | 1998-12-22 | Nellcor Puritan Bennett Incorporated | Pulse oximeter sensor with articulating head |
US5876357A (en) * | 1997-11-20 | 1999-03-02 | Labor Control System (L.C.S.) Ltd. | Uterine cervix dilation, effacement, and consistency monitoring system |
US5935061A (en) * | 1997-01-03 | 1999-08-10 | Biosense, Inc. | Obstetrical instrument system and method |
US5951497A (en) * | 1996-09-03 | 1999-09-14 | Clinical Innovation Associates, Inc. | Pressure catheter device with enhanced positioning features |
US5964783A (en) * | 1997-11-07 | 1999-10-12 | Arthrex, Inc. | Suture anchor with insert-molded suture |
US6039701A (en) * | 1996-09-05 | 2000-03-21 | Ob Inovations, Inc. | Method and apparatus for monitoring cervical diameter |
US6173715B1 (en) * | 1999-03-01 | 2001-01-16 | Lucent Medical Systems, Inc. | Magnetic anatomical marker and method of use |
US6200279B1 (en) * | 1997-05-05 | 2001-03-13 | Ultra-Guide Ltd. | Method and apparatus monitoring the progress of labor |
US6242004B1 (en) * | 1997-04-23 | 2001-06-05 | Permatec Technologie Ag | Bioadhesive tablets |
US6246898B1 (en) * | 1995-03-28 | 2001-06-12 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US6259753B1 (en) * | 1919-10-11 | 2001-07-10 | Hitachi, Ltd. | Data synchronizing signal detecting device |
US6261247B1 (en) * | 1998-12-31 | 2001-07-17 | Ball Semiconductor, Inc. | Position sensing system |
US6270458B1 (en) * | 1999-03-05 | 2001-08-07 | Barnev Inc. | Cervix dilation and labor progression monitor |
US20010012944A1 (en) * | 1997-10-01 | 2001-08-09 | Bicek Andrew D. | Stent delivery system using shape memory retraction |
US6285897B1 (en) * | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6332089B1 (en) * | 1996-02-15 | 2001-12-18 | Biosense, Inc. | Medical procedures and apparatus using intrabody probes |
US6352513B1 (en) * | 1999-06-25 | 2002-03-05 | Ampersand Medical Corporation | Personal cervical cell collector |
US20020028995A1 (en) * | 2000-04-10 | 2002-03-07 | Mault James R. | System and method for remote pregnancy monitoring |
US6371118B1 (en) * | 2000-06-07 | 2002-04-16 | Terry L. Ray | Birth control apparatus |
US6423000B1 (en) * | 2000-11-01 | 2002-07-23 | Daniel K. Berry | Labor monitoring device |
US6454716B1 (en) * | 2000-05-23 | 2002-09-24 | P.M.G. Medica Ltd. | System and method for detection of fetal heartbeat |
US20030022392A1 (en) * | 2001-07-25 | 2003-01-30 | Hudak Robert Thomas | Specimen collection container |
US6517481B2 (en) * | 1998-12-23 | 2003-02-11 | Radi Medical Systems Ab | Method and sensor for wireless measurement of physiological variables |
US6522916B1 (en) * | 2000-05-09 | 2003-02-18 | Ki Chul Kwon | Telemetric system for fetal care |
US6544614B1 (en) * | 2000-09-21 | 2003-04-08 | Sonoco Development, Inc. | Packaging with incorporated temperature sensitive label |
US6551252B2 (en) * | 2000-04-17 | 2003-04-22 | Vivometrics, Inc. | Systems and methods for ambulatory monitoring of physiological signs |
US20030114779A1 (en) * | 1997-05-05 | 2003-06-19 | Yoav Paltieli | Method and apparatus for monitoring the progress of labor |
US6636769B2 (en) * | 2000-12-18 | 2003-10-21 | Biosense, Inc. | Telemetric medical system and method |
US20040010273A1 (en) * | 2001-02-26 | 2004-01-15 | Diduch David R. | Superelastic suture passing devices and methods |
US20040220538A1 (en) * | 2003-04-22 | 2004-11-04 | Panopoulos Peter John | Hygienic diaper, sensor pad, and or sensing belt with alert, readout, transmission, paging, software & patient information database recording means for treating & caring for wetness, feces, & disease |
US20040236193A1 (en) * | 2001-06-05 | 2004-11-25 | Yehuda Sharf | Birth monitoring system |
US6905472B2 (en) * | 2002-11-13 | 2005-06-14 | Robert A. Welch | Incompetent cervix aide |
US20050149100A1 (en) * | 2002-12-12 | 2005-07-07 | O.S. Technology Llc | Cervical canal dilator |
US7002054B2 (en) * | 2001-06-29 | 2006-02-21 | The Procter & Gamble Company | Absorbent article having a fever indicator |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0135840A3 (fr) * | 1983-08-30 | 1986-06-11 | Nellcor Incorporated | Oxymètre à usage périnatologique |
WO1996014586A1 (fr) | 1994-11-02 | 1996-05-17 | Yosef Mintz | Procede et systeme de mise en correspondance et de recherche d'information a partir de plusieurs stations a distance |
IL109291A0 (en) | 1994-04-11 | 1994-07-31 | Mintz Yosef | Method and system for obtaining information from a plurality of remote stations |
WO1999035968A1 (fr) | 1998-01-13 | 1999-07-22 | Urometrics, Inc. | Procede et dispositif de surveillance de l'excitation sexuelle chez la femme |
WO2000021203A1 (fr) | 1998-10-02 | 2000-04-13 | Comsense Technologies, Ltd. | Emploi de signaux acoustiques pour communications par ordinateur |
CA2341907A1 (fr) | 1998-08-27 | 2000-03-09 | Comsense Technologies, Ltd. | Procede et systeme permettant de mesurer une distance depuis un element piezo-electrique |
EP1116155A2 (fr) | 1998-10-02 | 2001-07-18 | Comsense Technologies Ltd. | Carte permettant d'interagir avec un ordinateur |
EP1026219A1 (fr) | 1999-02-02 | 2000-08-09 | First Water Limited | Composition bioadhésive |
WO2000047644A1 (fr) | 1999-02-12 | 2000-08-17 | Universiteit Gent | Systeme adhesif biocompatible et systeme d'administration de medicaments bioadhesifs a liberation controlee |
-
2002
- 2002-06-05 JP JP2003501320A patent/JP2004535861A/ja active Pending
- 2002-06-05 JP JP2003501321A patent/JP2004533298A/ja active Pending
- 2002-06-05 EP EP02735956A patent/EP1420697A4/fr not_active Withdrawn
- 2002-06-05 EP EP02735957A patent/EP1420693A4/fr not_active Withdrawn
- 2002-06-05 WO PCT/IL2002/000441 patent/WO2002098272A2/fr active Application Filing
- 2002-06-05 AU AU2002309238A patent/AU2002309238A1/en not_active Abandoned
- 2002-06-05 IL IL15920802A patent/IL159208A0/xx unknown
- 2002-06-05 AU AU2002309239A patent/AU2002309239A1/en not_active Abandoned
- 2002-06-05 WO PCT/IL2002/000440 patent/WO2002098271A2/fr active Application Filing
- 2002-06-05 IL IL15917402A patent/IL159174A0/xx unknown
- 2002-06-05 US US10/479,826 patent/US7207941B2/en not_active Expired - Fee Related
- 2002-06-05 US US10/480,008 patent/US20040153008A1/en not_active Abandoned
Patent Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6259753B1 (en) * | 1919-10-11 | 2001-07-10 | Hitachi, Ltd. | Data synchronizing signal detecting device |
US2924220A (en) * | 1959-02-20 | 1960-02-09 | Micsky Lajos I Von | Cervicometer |
US3090862A (en) * | 1959-08-31 | 1963-05-21 | Berk Sigmund | Radioactive temperature indicating devices |
US3533274A (en) * | 1966-03-21 | 1970-10-13 | Peter Harold Howard Bishop | Apparatus and method for determining thermal conductivity |
US3811443A (en) * | 1971-01-22 | 1974-05-21 | Agrophysic Inc | Method and apparatus for artificial insemination |
US3768459A (en) * | 1971-06-28 | 1973-10-30 | Utah Res & Dev Co Inc | Cervical dilation measuring device |
US4160971A (en) * | 1975-05-02 | 1979-07-10 | National Research Development Corporation | Transponders |
US4248089A (en) * | 1975-09-08 | 1981-02-03 | Ferdinand Heinmets | Temperature measuring |
US4141345A (en) * | 1976-01-08 | 1979-02-27 | National Research Development Corporation | Cervical dilation measurement instruments |
US4151831A (en) * | 1976-11-15 | 1979-05-01 | Safetime Monitors, Inc. | Fertility indicator |
US4151835A (en) * | 1978-03-08 | 1979-05-01 | John Copeland | Foetal scalp electrodes |
US4294258A (en) * | 1978-03-23 | 1981-10-13 | Agence Nationale De Valorisation De La Recherche (Anvar) | Measuring head enabling the production of physiological measurement signals designed to be positioned on or in corporeal parts |
US4345470A (en) * | 1978-09-28 | 1982-08-24 | Akzona Incorporated | All plastic disposable thermometer |
US4488558A (en) * | 1981-06-16 | 1984-12-18 | Innova Wiener Innovationsgesellschaft M.B.H. | Birth monitor |
US4475560A (en) * | 1982-04-29 | 1984-10-09 | Cordis Corporation | Temporary pacing lead assembly |
US4543965A (en) * | 1982-06-13 | 1985-10-01 | Ben-Gurion University Of The Negev Research And Development Authority | Method and device for measuring intrauterine pressure |
US4619301A (en) * | 1982-12-23 | 1986-10-28 | Agency Of Industrial Science And Technology | Spike tire |
US4776346A (en) * | 1984-02-10 | 1988-10-11 | Dan Beraha | Biopsy instrument |
US4990161A (en) * | 1984-03-16 | 1991-02-05 | Kampner Stanley L | Implant with resorbable stem |
US4677967A (en) * | 1984-11-01 | 1987-07-07 | New Mexico State University Foundation | Intravaginal anchor |
US4836208A (en) * | 1985-12-24 | 1989-06-06 | American Home Products Corporation (Del.) | Electrode assembly for sensing heart activity |
US4686996A (en) * | 1985-12-24 | 1987-08-18 | Paul Ulbrich | Electrode assembly for sensing heart activity |
US4945305A (en) * | 1986-10-09 | 1990-07-31 | Ascension Technology Corporation | Device for quantitatively measuring the relative position and orientation of two bodies in the presence of metals utilizing direct current magnetic fields |
US4867177A (en) * | 1987-05-15 | 1989-09-19 | Gynex, Inc. | Vaginal drape, insertion unit and kit |
US5169914A (en) * | 1988-05-03 | 1992-12-08 | Edison Polymer Innovation Corporation | Uniform molecular weight polymers |
US5137028A (en) * | 1989-10-18 | 1992-08-11 | Nishimoto, Co., Ltd. | Clinical thermometer for women |
US5222485A (en) * | 1990-09-17 | 1993-06-29 | Ravinder Jerath | Ultrasound labor monitoring method and apparatus |
US5353354A (en) * | 1990-11-22 | 1994-10-04 | Advanced Technology Laboratories, Inc. | Acquisition and display of ultrasonic images from sequentially oriented image planes |
US5211165A (en) * | 1991-09-03 | 1993-05-18 | General Electric Company | Tracking system to follow the position and orientation of a device with radiofrequency field gradients |
US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5259395A (en) * | 1992-01-15 | 1993-11-09 | Siemens Pacesetter, Inc. | Pacemaker lead with extendable retractable lockable fixing helix |
US5284141A (en) * | 1992-07-31 | 1994-02-08 | Eibling David L | Electrode emplacement apparatus for amniotomy and fetal monitoring and method of use |
US5645062A (en) * | 1993-02-15 | 1997-07-08 | Anderson; John Mccune | Biomedical electrode device |
US5497771A (en) * | 1993-04-02 | 1996-03-12 | Mipm Mammendorfer Institut Fuer Physik Und Medizin Gmbh | Apparatus for measuring the oxygen saturation of fetuses during childbirth |
US5538005A (en) * | 1993-06-25 | 1996-07-23 | The Regents Of The University Of California | B'method for monitoring fetal characteristics by radiotelemetric transmission |
US5423323A (en) * | 1993-08-30 | 1995-06-13 | Rocky Mountain Research, Inc. | System for calculating compliance and cardiac hemodynamic parameters |
US5388579A (en) * | 1993-09-23 | 1995-02-14 | Graphic Controls Corporation | Fetal electrode product with channeled drive mechanism and improved torque characteristics |
US5492119A (en) * | 1993-12-22 | 1996-02-20 | Heart Rhythm Technologies, Inc. | Catheter tip stabilizing apparatus |
US5833622A (en) * | 1994-04-04 | 1998-11-10 | Graphic Controls Corporation | Non-invasive fetal probe having improved mechanical and electrical properties |
US5816707A (en) * | 1994-05-06 | 1998-10-06 | Minnesota Mining And Manufacturing Company | Reversible chemical thermometer |
US6241385B1 (en) * | 1994-05-06 | 2001-06-05 | 3M Innovative Properties Co | Reversible chemical thermometer |
US5851188A (en) * | 1994-10-12 | 1998-12-22 | Bullard; Kelli M. | Device for holding medical instrumentation sensors at and upon the cervix os of a human female, particularly for holding the ultrasonic transducers of an ultrasonic transit time, real-time, cervical effacement and dilatation monitor |
US5829438A (en) * | 1994-10-12 | 1998-11-03 | Gibbs; David L. | System and method for the infusing of tocolytic drugs in response to the onset of premature labor detected by ultrasonic monitoring of the dilatation and/or effacement of the cervix os |
US5438996A (en) * | 1994-10-12 | 1995-08-08 | Triton Technology, Inc. | Ambulatory, ultrasonic transit time, real-time, cervical effacement and dilatation monitor with disposable probes |
US5817035A (en) * | 1994-11-24 | 1998-10-06 | The Institute Of Respiratory Medicine Ltd. | Biophysical foetal monitor |
US5515853A (en) * | 1995-03-28 | 1996-05-14 | Sonometrics Corporation | Three-dimensional digital ultrasound tracking system |
US6246898B1 (en) * | 1995-03-28 | 2001-06-12 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US5817108A (en) * | 1995-06-07 | 1998-10-06 | Medtronic, Inc. | Device and method for suturing wound |
US5843076A (en) * | 1995-06-12 | 1998-12-01 | Cordis Webster, Inc. | Catheter with an electromagnetic guidance sensor |
US5713371A (en) * | 1995-07-07 | 1998-02-03 | Sherman; Dani | Method of monitoring cervical dilatation during labor, and ultrasound transducer particularly useful in such method |
US5680859A (en) * | 1995-10-11 | 1997-10-28 | Graphic Controls Corporation | Integrated introducer and drive rod positioning system for a fetal spiral electrode |
US5671736A (en) * | 1995-10-17 | 1997-09-30 | Graphic Controls Corporation | Fetal electrode product with easy-to-handle connector |
US6332089B1 (en) * | 1996-02-15 | 2001-12-18 | Biosense, Inc. | Medical procedures and apparatus using intrabody probes |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5951497A (en) * | 1996-09-03 | 1999-09-14 | Clinical Innovation Associates, Inc. | Pressure catheter device with enhanced positioning features |
US5727547A (en) * | 1996-09-04 | 1998-03-17 | Nellcor Puritan Bennett Incorporated | Presenting part fetal oximeter sensor with securing mechanism for providing tension to scalp attachment |
US6039701A (en) * | 1996-09-05 | 2000-03-21 | Ob Inovations, Inc. | Method and apparatus for monitoring cervical diameter |
US5807281A (en) * | 1996-10-01 | 1998-09-15 | Welch; Robert A. | Cervical ring to detect labor |
US5851179A (en) * | 1996-10-10 | 1998-12-22 | Nellcor Puritan Bennett Incorporated | Pulse oximeter sensor with articulating head |
US5935061A (en) * | 1997-01-03 | 1999-08-10 | Biosense, Inc. | Obstetrical instrument system and method |
US5807271A (en) * | 1997-04-14 | 1998-09-15 | Tayebi; Sean | Fetal heartbeat and uterine contraction |
US6242004B1 (en) * | 1997-04-23 | 2001-06-05 | Permatec Technologie Ag | Bioadhesive tablets |
US6200279B1 (en) * | 1997-05-05 | 2001-03-13 | Ultra-Guide Ltd. | Method and apparatus monitoring the progress of labor |
US6669653B2 (en) * | 1997-05-05 | 2003-12-30 | Trig Medical Ltd. | Method and apparatus for monitoring the progress of labor |
US20030114779A1 (en) * | 1997-05-05 | 2003-06-19 | Yoav Paltieli | Method and apparatus for monitoring the progress of labor |
US20010012944A1 (en) * | 1997-10-01 | 2001-08-09 | Bicek Andrew D. | Stent delivery system using shape memory retraction |
US5964783A (en) * | 1997-11-07 | 1999-10-12 | Arthrex, Inc. | Suture anchor with insert-molded suture |
US5876357A (en) * | 1997-11-20 | 1999-03-02 | Labor Control System (L.C.S.) Ltd. | Uterine cervix dilation, effacement, and consistency monitoring system |
US6517481B2 (en) * | 1998-12-23 | 2003-02-11 | Radi Medical Systems Ab | Method and sensor for wireless measurement of physiological variables |
US6261247B1 (en) * | 1998-12-31 | 2001-07-17 | Ball Semiconductor, Inc. | Position sensing system |
US6173715B1 (en) * | 1999-03-01 | 2001-01-16 | Lucent Medical Systems, Inc. | Magnetic anatomical marker and method of use |
US6270458B1 (en) * | 1999-03-05 | 2001-08-07 | Barnev Inc. | Cervix dilation and labor progression monitor |
US6285897B1 (en) * | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6352513B1 (en) * | 1999-06-25 | 2002-03-05 | Ampersand Medical Corporation | Personal cervical cell collector |
US20020028995A1 (en) * | 2000-04-10 | 2002-03-07 | Mault James R. | System and method for remote pregnancy monitoring |
US6551252B2 (en) * | 2000-04-17 | 2003-04-22 | Vivometrics, Inc. | Systems and methods for ambulatory monitoring of physiological signs |
US6522916B1 (en) * | 2000-05-09 | 2003-02-18 | Ki Chul Kwon | Telemetric system for fetal care |
US6454716B1 (en) * | 2000-05-23 | 2002-09-24 | P.M.G. Medica Ltd. | System and method for detection of fetal heartbeat |
US6371118B1 (en) * | 2000-06-07 | 2002-04-16 | Terry L. Ray | Birth control apparatus |
US6544614B1 (en) * | 2000-09-21 | 2003-04-08 | Sonoco Development, Inc. | Packaging with incorporated temperature sensitive label |
US6423000B1 (en) * | 2000-11-01 | 2002-07-23 | Daniel K. Berry | Labor monitoring device |
US6636769B2 (en) * | 2000-12-18 | 2003-10-21 | Biosense, Inc. | Telemetric medical system and method |
US20040010273A1 (en) * | 2001-02-26 | 2004-01-15 | Diduch David R. | Superelastic suture passing devices and methods |
US20040236193A1 (en) * | 2001-06-05 | 2004-11-25 | Yehuda Sharf | Birth monitoring system |
US7207941B2 (en) * | 2001-06-05 | 2007-04-24 | Barnev Ltd. | Birth monitoring system |
US7002054B2 (en) * | 2001-06-29 | 2006-02-21 | The Procter & Gamble Company | Absorbent article having a fever indicator |
US20030022392A1 (en) * | 2001-07-25 | 2003-01-30 | Hudak Robert Thomas | Specimen collection container |
US6905472B2 (en) * | 2002-11-13 | 2005-06-14 | Robert A. Welch | Incompetent cervix aide |
US20050149100A1 (en) * | 2002-12-12 | 2005-07-07 | O.S. Technology Llc | Cervical canal dilator |
US20040220538A1 (en) * | 2003-04-22 | 2004-11-04 | Panopoulos Peter John | Hygienic diaper, sensor pad, and or sensing belt with alert, readout, transmission, paging, software & patient information database recording means for treating & caring for wetness, feces, & disease |
Cited By (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7753842B2 (en) | 2001-06-28 | 2010-07-13 | Given Imaging Ltd. | In vivo imaging device with a small cross sectional area |
US20100137686A1 (en) * | 2002-04-25 | 2010-06-03 | Gavriel Meron | Device and method for orienting a device in vivo |
US7946979B2 (en) * | 2002-12-26 | 2011-05-24 | Given Imaging, Ltd. | Immobilizable in vivo sensing device |
US20050143624A1 (en) * | 2003-12-31 | 2005-06-30 | Given Imaging Ltd. | Immobilizable in-vivo imager with moveable focusing mechanism |
US8702597B2 (en) | 2003-12-31 | 2014-04-22 | Given Imaging Ltd. | Immobilizable in-vivo imager with moveable focusing mechanism |
US8257394B2 (en) | 2004-05-07 | 2012-09-04 | Usgi Medical, Inc. | Apparatus and methods for positioning and securing anchors |
US8845512B2 (en) | 2005-11-14 | 2014-09-30 | C. R. Bard, Inc. | Sling anchor system |
US20070270651A1 (en) * | 2006-05-19 | 2007-11-22 | Zvika Gilad | Device and method for illuminating an in vivo site |
US8870916B2 (en) | 2006-07-07 | 2014-10-28 | USGI Medical, Inc | Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use |
US8480559B2 (en) | 2006-09-13 | 2013-07-09 | C. R. Bard, Inc. | Urethral support system |
US8206280B2 (en) | 2007-11-13 | 2012-06-26 | C. R. Bard, Inc. | Adjustable tissue support member |
US8574149B2 (en) | 2007-11-13 | 2013-11-05 | C. R. Bard, Inc. | Adjustable tissue support member |
WO2009143255A1 (fr) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Système d’auto-injection |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US11883633B2 (en) | 2008-05-20 | 2024-01-30 | Avant Medical Corp. | Autoinjector system |
US9974904B2 (en) | 2008-05-20 | 2018-05-22 | Avant Medical Corp. | Autoinjector system |
US9925336B2 (en) | 2008-05-20 | 2018-03-27 | Avant Medical Corp. | Cassette for a hidden injection needle |
US10864324B2 (en) | 2008-05-20 | 2020-12-15 | Avant Medical Corp. | Autoinjector system |
US10792426B2 (en) | 2008-05-20 | 2020-10-06 | Avant Medical Corp. | Autoinjector system |
US20090292246A1 (en) * | 2008-05-20 | 2009-11-26 | Slate John B | Cassette for a hidden injection needle |
US10639422B2 (en) | 2008-07-23 | 2020-05-05 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US20100022955A1 (en) * | 2008-07-23 | 2010-01-28 | Slate John B | System and method for an injection using a syringe needle |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US9616173B2 (en) | 2008-07-23 | 2017-04-11 | Avant Medical Corporation | System and method for an injection using a syringe needle |
US11724032B2 (en) | 2008-07-23 | 2023-08-15 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US20150012076A1 (en) * | 2009-07-03 | 2015-01-08 | Advanced Neuromodulation Systems, Inc. dba St. Jude Neuromodulation Division | Implantable anchor with locking cam |
US20110004281A1 (en) * | 2009-07-03 | 2011-01-06 | Jones Robert E | Implantable anchor with locking cam |
US20130138191A1 (en) * | 2009-07-03 | 2013-05-30 | Advanced Neuromodulation Systems, Inc. | Implantable anchor with locking cam |
US8801623B2 (en) | 2010-01-14 | 2014-08-12 | Koninklijke Philips N.V. | Sensor determining a physical or physiological parameter |
WO2011086481A1 (fr) | 2010-01-14 | 2011-07-21 | Koninklijke Philips Electronics N.V. | Capteur déterminant un paramètre physique ou physiologique |
US20120253144A1 (en) * | 2011-03-29 | 2012-10-04 | Olympus Corporation | Sensor |
US11419990B2 (en) | 2011-04-20 | 2022-08-23 | Amgen Inc. | Autoinjector apparatus |
US10918805B2 (en) | 2011-04-20 | 2021-02-16 | Amgen Inc. | Autoinjector apparatus |
US11986643B2 (en) | 2011-04-20 | 2024-05-21 | Amgen Inc. | Autoinjector apparatus |
US10092706B2 (en) | 2011-04-20 | 2018-10-09 | Amgen Inc. | Autoinjector apparatus |
US9119615B2 (en) | 2011-12-15 | 2015-09-01 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9113867B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9113879B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US10292703B2 (en) | 2011-12-15 | 2019-05-21 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9113866B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9113868B2 (en) | 2011-12-15 | 2015-08-25 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9173657B2 (en) | 2011-12-15 | 2015-11-03 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US10687808B2 (en) | 2011-12-15 | 2020-06-23 | Ethicon Endo-Surgery, Inc. | Devices and methods for endoluminal plication |
US9980716B2 (en) | 2012-03-21 | 2018-05-29 | Ethicon Llc | Methods and devices for creating tissue plications |
US10595852B2 (en) | 2012-03-21 | 2020-03-24 | Ethicon Llc | Methods and devices for creating tissue plications |
US8992547B2 (en) | 2012-03-21 | 2015-03-31 | Ethicon Endo-Surgery, Inc. | Methods and devices for creating tissue plications |
USD829890S1 (en) | 2012-04-20 | 2018-10-02 | Amgen Inc. | Injection device |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
US10292731B2 (en) * | 2012-08-27 | 2019-05-21 | Terumo Kabushiki Kaisha | Medical tube, medical tube assembly and puncture needle |
US20150164549A1 (en) * | 2012-08-27 | 2015-06-18 | Terumo Kabushiki Kaisha | Medical tube, medical tube assembly and puncture needle |
US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US11020537B2 (en) | 2013-03-15 | 2021-06-01 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US11944798B2 (en) | 2013-03-15 | 2024-04-02 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10786629B2 (en) | 2013-03-15 | 2020-09-29 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US11712248B2 (en) | 2014-04-14 | 2023-08-01 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Delaying pre-term birth |
US20230190232A1 (en) * | 2016-03-21 | 2023-06-22 | Isono Health, Inc. | Wearable ultrasound system and method |
WO2019244159A1 (fr) | 2018-06-21 | 2019-12-26 | Pregnantech Ltd. | Retardement d'une naissance avant terme |
CN113164111A (zh) * | 2018-10-02 | 2021-07-23 | 生命轨迹私人有限公司 | 用于监测胎儿中的分析物浓度的装置、系统和方法 |
US11622705B2 (en) * | 2019-10-16 | 2023-04-11 | James Robert Balman | Apparatus and method for determining physiological parameters of an infant in-utero |
US20220110552A1 (en) * | 2019-10-16 | 2022-04-14 | James Robert Balman | Apparatus and method for determining physiological parameters of an infant in-utero |
WO2021209873A1 (fr) * | 2020-04-12 | 2021-10-21 | Uc-Care Ltd | Procédé et système de guidage d'aiguille trans-périnéale à base de capteur |
Also Published As
Publication number | Publication date |
---|---|
EP1420693A4 (fr) | 2007-05-30 |
US7207941B2 (en) | 2007-04-24 |
US20040236193A1 (en) | 2004-11-25 |
WO2002098272A3 (fr) | 2004-03-18 |
WO2002098272A2 (fr) | 2002-12-12 |
IL159174A0 (en) | 2004-06-01 |
JP2004533298A (ja) | 2004-11-04 |
AU2002309238A1 (en) | 2002-12-16 |
JP2004535861A (ja) | 2004-12-02 |
EP1420697A2 (fr) | 2004-05-26 |
WO2002098271A2 (fr) | 2002-12-12 |
IL159208A0 (en) | 2004-06-01 |
EP1420697A4 (fr) | 2007-05-30 |
WO2002098271A3 (fr) | 2004-03-18 |
AU2002309239A1 (en) | 2002-12-16 |
EP1420693A2 (fr) | 2004-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20040153008A1 (en) | Probe anchor | |
US7172603B2 (en) | Deployable constrictor for uterine artery occlusion | |
US7354444B2 (en) | Occlusion device with deployable paddles for detection and occlusion of blood vessels | |
US9707124B2 (en) | Methods and apparatus for occlusion of body lumens | |
KR100213554B1 (ko) | 태아용 탐침 | |
CA2442341C (fr) | Dispositifs et methodes d'identification, de caracterisation et d'occlusion des arteres uterines multiaxiales | |
EP1691697B1 (fr) | Dispositif d'occlusion d'une artere uterine equipe d'un support cervical | |
US20040097961A1 (en) | Tenaculum for use with occlusion devices | |
US20040153097A1 (en) | Treatment for post partum hemorrhage | |
AU2002254414A1 (en) | Uterine artery characterization, and occlusion device | |
WO2010048141A2 (fr) | Dispositifs et procédés de ligature de tissus | |
US20210236170A1 (en) | Delaying pre-term birth | |
AU2004210661A1 (en) | Vascular clamp for ceasarian section | |
US20120150193A1 (en) | System and methods for hysteroscopic tubular ligation | |
US20040172051A1 (en) | Method and apparatus for tubal occlusion | |
WO2008057566A2 (fr) | Dispositif d'imagerie par ultrasons pouvant être fixé | |
JP2005176907A (ja) | 体腔内留置型検査装置 | |
US20210212659A1 (en) | Vascular Monitoring Collar |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BARNEV LTD., ISRAEL Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SHARF, YEHUDA;BETZALEL, MOSHE;REEL/FRAME:015058/0703 Effective date: 20040113 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |