WO2007117478A2 - processus chirurgicaux - Google Patents

processus chirurgicaux Download PDF

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Publication number
WO2007117478A2
WO2007117478A2 PCT/US2007/008331 US2007008331W WO2007117478A2 WO 2007117478 A2 WO2007117478 A2 WO 2007117478A2 US 2007008331 W US2007008331 W US 2007008331W WO 2007117478 A2 WO2007117478 A2 WO 2007117478A2
Authority
WO
WIPO (PCT)
Prior art keywords
transponder
surgery
locating
scanning
target tissue
Prior art date
Application number
PCT/US2007/008331
Other languages
English (en)
Other versions
WO2007117478A3 (fr
Inventor
Robert J. Petcavich
Murray Reicher
Original Assignee
Health Beacons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/002313 external-priority patent/WO2007087447A2/fr
Application filed by Health Beacons, Inc. filed Critical Health Beacons, Inc.
Publication of WO2007117478A2 publication Critical patent/WO2007117478A2/fr
Publication of WO2007117478A3 publication Critical patent/WO2007117478A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags
    • A61B90/98—Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A61B2090/3908—Soft tissue, e.g. breast tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/397—Markers, e.g. radio-opaque or breast lesions markers electromagnetic other than visible, e.g. microwave
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry

Definitions

  • This invention relates to surgery performed on the bodies of humans and animals for removal of suspect tissue, such as cancer, malignancies, tumors and diseased organs, and for removal of foreign objects, such as bullets-
  • the invention is concerned with the identification of a surgical site and the location of suspect tissue for the benefit of an operating surgeon or veterinarian. More particularly, this invention relates to improved methodology to identify the region of surgical interest and the location of tissue that is to be removed by surgery, and subsequent verification of removal of such tissue.
  • breast cancer One disease for which biopsy is a critical tool is breast cancer. This affliction is responsible for 18% of all cancer deaths in women and is the leading cause of death among women aged 40 to 55.
  • biopsy In the detection and treatment of breast cancer, there are two general classes of biopsy: the minimally invasive percutaneous biopsy and the more invasive surgical, or "open", biopsy.
  • Percutaneous biopsies include the use of fine needles or larger diameter core needles. They may be used on palpable lesions or under stereotactic x-ray, ultrasonic, or other guidance techniques for nonpalpable lesions and microcalcifications (which are often precursors to metastatic cell growth).
  • fine needle biopsy a physician inserts a small needle directly into the lesion and obtains a few cells with a syringe. Not only does this technique require multiple samples, but each sample is difficult for the cytologist to analyze as the specimen cells are isolated outside the context of healthy surrounding tissue.
  • MAMMOTOME vacuum aspiration system by Johnson & Johnson of New Brunswick, N.J., the ABBI system by United States Surgical Corporation, Norwalk, Conn., and the STTESELECT system by ⁇ magyn, Inc. of Irvine, Calif.
  • Open biopsies are advisable when suspicious lumps should be removed in their entirety or when core needle biopsies do not render sufficient information about the nature of the lesion.
  • One such type of open biopsy is the wire localization
  • a radiologist inserts a small needle into the breast and passes the needle to the suspect tissue.
  • the radiologist then passes a wire with a hook on its end through the needle and positions the hook so that the end of the wire is distal to the suspect tissue.
  • a final image is taken of the lesion with the accompanying wire in place, and the radiologist marks the film for x-ray indicators of a suspicious lesion that should be removed.
  • the wire is left in the tissue and the patient is taken to the operating room, where the suspect tissue is removed by a surgeon.
  • the removed tissue is then sent from the operating room to a radiologist to determine, via x-ray examination, if the tissue contains the x-ray indicators and if the size and borders are adequate to confirm the removal of all suspicious tissue.
  • wire markers are known in the art. See, e.g., the following patents, each of which is incorporated herein by reference: U.S. Pat. No. 5,158,084 to Ghiatas, U.S. Pat. No. 5,409,004 to Sloan, U.S. Pat. No. 5,059,197 to
  • the surgeon must guide a scalpel along the wire and rely upon the skill of the radiologist and the marked x-ray film in the excision procedure. Even if the wire has been properly placed in the lesion and the x-ray film clearly shows the lesion boundary or margin, the surgeon often cannot see the tip of the wire (given the surrounding tissue) so she must remove a larger portion of tissue than is necessary to ensure proper excision.
  • the surgeon ends up cutting or removing non-afflicted tissue without removing the lesion. Also, if the tip of the wire penetrates the lesion, the surgeon may sever the lesion in cutting through the tissue along the wire to reach its end. Tn the latter case, a re-excision may be
  • two paddles are typically used to compress and stabilize the breast for placement of the wire.
  • the wire marker can dislodge or migrate to another position away from the suspect tissue. It may also migrate while the patient awaits surgery.
  • the fact that the breast is in an uncompressed- .state during the excision procedure renders a different view of the lesion with respect to the healthy tissue.
  • tissue localization systems have been developed to minimize inadvertent migration of the wire by configuring the wire with a bend or hook, such as
  • MAMMALOK needle/wire localizer sold by Mitek Surgical Products, Inc., Dedham,
  • the location procedure must be scheduled immediately prior to surgery, requiring coordination of scheduling between a radiologist and a surgeon, and between an image suite and a surgical suite.
  • the surgeon is generally committed to following the same surgical approach that the radiologists used to place the wire.
  • the optimal skin entry position and angle of the wire that is optimal for imaging i placement is not the
  • Metallic tags such as titanium clips, may similarly be implanted in a patient's body to mark the location of suspect tissue, particularly rum, for the benefit of an operating surgeon or veterinarian.
  • metallic markers suffer many of the same limitations as hookwires.
  • metallic markers require radiological imagining in the operating room and/or the transport of specimen's outside of the operating room to an imagining suite to radiographically confirm that the marker is in the resected lesion.
  • tissues, organ and object locating device that may be accurately yet removably placed into a target area or surgical site, i.e., a region of tissue that contains suspect tissues, preferably without penetrating or disturbing that volume of tissue.
  • a target area or surgical site i.e., a region of tissue that contains suspect tissues, preferably without penetrating or disturbing that volume of tissue.
  • Such a device should reliably define the location and volume of tissue to be removed without the risk of inadvertent migration of the device.
  • a need remains to improve the interaction between the radiologist and the surgeon, to eliminate the need for post-excision x-rays and re-excision, to reduce the overall time for the procedure, and to allow a surgeon to select the shortest or most cosmetically desirable path to the suspect tissue.
  • Another object of the invention is to provide a method of and select
  • apparatus for enabling a surgeon performing an operation to identify and locate suspect tissue, organs and objects in a body, usually from the exterior of the body, remotely of the suspect tissue or object. It is in particular an object of the invention to provide improved methodology and select apparatus for identifying and locating suspect tissues, organs and objects in a body utilizing microencapulation and radio frequency technologies.
  • the invention resides in a method of use of microencapsulated, implantable, passive integrated transponder (PIT) elements or tags, a device, such for example as a thin needle syringe or deployment device, for implanting one or more of the miniature PIT tags proximate a target organ, tissue or object, and a radio frequency probe, scanner or reader manipulated externally of the body for locating and identifying the implanted tag or tags and thus the location and
  • PIT passive integrated transponder
  • volume of tissue to be excised by the surgeon is the volume of tissue to be excised by the surgeon.
  • the locator PIT element or tag includes a transponder that is passive
  • the element is partially or totally radiopaque and shaped to penetrate tissue so that at least a portion of the locator element when implanted in a body defines a tissue border along a first path.
  • the tissue border defines a volume of tissue for subsequent excision along the border, and contains a target region that is substantially bounded by or in proximity to the PIT locator element.
  • the invention involves placing removable locator elements in tissue. This. is accomplished by penetrating through tissue at a first site to create a port or a pathway for accessing a targeted tissue volume to be excised, inserting a deployment needle or device into the area of tissue of interest and using the needle or device to deploy and implant the PIT element.
  • the tissue volume will contain a target region that is substantially near but not penetrated by the locator element.
  • the PIT locator element may be placed under x-ray guidance, stereotactic x-ray guidance, ultrasonic guidance, magnetic resonance imaging guidance, and the like. Target region visibility may be enhanced by, for example, the placement or injection of an echogenic substance, such as collagen, hydrogels, microspheres, or other like biocompatible materials, or by the injection of air or other biocompatible gases or contrast agents.
  • an echogenic substance such as collagen, hydrogels, microspheres, or other like biocompatible materials
  • second, third and even more locator PIT elements or tags may be advanced through the distal end of the deployment needle or device to penetrate tissue
  • the additional paths may be parallel or non-parallel to the first
  • the method includes the step of excising the tissue volume defined by the one or more PIT locator elements. This may be accomplished by surgically accessing the locator element and cutting tissue substantially along the surface of the locator element opposite the surface that is disposed immediately adjacent the tissue volume.
  • the method includes the use of an external hand held or stationary radio frequency emitting probe, scanner or reader that locates the PIT element, imparts electrical power to the PIT element and causes the element to transmit back to the antenna probe a signal of its location and an unique identification number assigned to the tag to verify the identity of the patient and the surgical procedure to be performed.
  • the radio frequency probe or scanner is again employed to scan one or the other or both of the surgical field, to determine the absence therefrom of the PIT tag or tags, and the excised tissue, to determine the presence therein of the tag or tags, thereby to ensure that the target tissue, organ or object has been successfully excised.
  • This step eliminates or at least minimizes the need for radiological re-imaging in the operating room and/or transporting excised tissue from the operating room to an imaging facility for re-imaging and x-ray analysis and/or for
  • the method of the invention furthermore comprises
  • the grid dip oscillator includes the use during surgery of a grid dip oscillator to pin point, i.e., to identify with precision, the location and orientation of each of the PIT tags or elements implanted in the patient's body.
  • the grid dip oscillator emits a radio frequency signal that energizes each of the PIT tags and causes the same to emit an electromagnetic field which can be scanned by the osciltator to determine with exactitude the precise location and orientation of each tag. This enables the surgeon to determine the most advantageous avenue of approach to and procedure for excision of a target tissue,
  • one- or more of the PIT locator elements or tags are implanted in the patient's body, usually by a
  • the PIT tags are small and embedded in tissue and do not protrude from the body, they are not prone to displacement or dislodgement, and since the tags remain passive until energized from an external radio frequency (RF) source, there is no need to rush or expedite transport of the patient from the radiologist to the surgical suite. It is not necessary to schedule simultaneous or immediately sequential availability of a radiological suite and a surgical suite. A reasonable period of time may elapse between implantation of the PIT tags and performance of the surgery. At the time of surgery, a radio frequency emitting identification (RFID)
  • RFID radio frequency emitting identification
  • the scanner is moved or swept over the exterior of the patient's body to energize the tag or tags implanted in the body and to cause the same to emit a signal, readable by the
  • a radio frequency emitting grid dip oscillator is then employed as a precision instrument to energize the implanted tag or tags, to read the signal or signals emitted by the tag or tags, and to identify with exactitude the location and orientation of each of the tags.
  • the grid dip oscillator may be deployed externally of the patient's body and/or within the incision during surgery to aid the surgeon in performance of the surgery.
  • the grid dip oscillator is designed to provide a visible signal and/or an audible signal denoting proximity to each PIT element or tag during surgery, thereby to guide the surgeon throughout the course of the surgical procedure, and to insure precise excision of the target tissue, organ or object.
  • the invention thus assures efficient and reliable location and identification of target tissue, precise and reliable excision of the tissue, significantly less reliance on and/or need for imagining, re-imaging and re-excision, and less time consuming and more efficient and practicable surgical procedures then provided by prior practices.
  • FIG. 1 is a side view of a radio frequency responsive implantable passive integrated transponder element or tag useful in practice of the present
  • FlG. 2 is a side view of an illustrative hypodermic syringe that is representative of devices useful as an implantation or deployment device in practice of the invention
  • FIG. 3 is a plan view of a radio frequency scanner/reader useful for practice of the invention.
  • FIG. 4 is a plan view of a radio frequency grid dip oscillator useful for practice of the invention.
  • FIG. 5 is an illustration of the mode of use of a grid dip oscillator in practice of the invention.
  • the invention may be used to mark tissue in a variety of locations in the body of a human being or an animal, such as the liver, the lungs, muscle tissue, bones, or other tissue or organs where the advantages of the invention may be realized. It may also be used to mark foreign objects in tissue or body cavities, such as a bullet or the like. Accordingly, the invention as described and claimed below is not limited to the marking and removal of lesions in breast tissue.
  • FIG. 1 illustrates an implantable, passive integrated transponder (PIT) element or tag 10 useful in practice of the invention.
  • the PIT elementlO comprises a passive integrated transponder 12 attached to a microchip 14 and encapsulated in an implantable glass shell 16.
  • Passive integrated transponders have no battery so the micro chip remains inactive until energized by radio or other low frequency energy from an external source, such as the scanner/reader 30 illustrated in Fig. 3 or the grid dip oscillator 40 illustrated in Fig. 4.
  • the micro chip 14 in the tag 10 is pre-recorded with a unique code, such as an alphabetic, numeric or alphanumeric code, identifying for example, the identity
  • the scanner 30 sends a low frequency signal to the transponder and micro chip within the tag providing power needed to interrogate the chip and send its unique code back to the scanner thereby to positively identify the tag or element and provide its approximate location in the body.
  • the dip grid oscillator 46 sends a low frequency signal to the tag 10 providing power to cause emission from the tag of an electromagnetic field that
  • the oscillator is readable by the oscillator to pin-point, i.e., to determine with reasonable precision, the location and the orientation of the tag or element in the body.
  • the distance from which the PIT tag can be read is called the read range.
  • PIT elements can be read through materials such as plastic, water and living tissue. In the present invention, it
  • the PIT elements can be read from a distance of 0.1 to 20 centimeters, with a preferred range of from immediate proximity up to about 7-10
  • centimeters centimeters.
  • Currently useful range is from proximity up to about 2 centimeters.
  • the frequency used by the PIT element to transmit its location and information is also significant.
  • the present invention utilizes 134.2 KHz as its most preferred transponder frequency so as not to be absorbed by or interfered with by living tissue, body fluids, or water.
  • the range of useful frequencies can be from 1 Hertz to 5 Giga Hertz with 13 Kilo Hertz (kHz) to 150 kHz being preferred.
  • Implantation or deployment in a body of one or more of the implantable PIT tags 10 is suitably accomplished by use of any of a number of tag deployment needles or devices, for example, a hypodermic syringe, such as the syringe 20 illustratively depicted in Fig. 2.
  • the syringe 20 includes a body 22, a hollow needle 24 for penetrating tissue and a plunger 26 for ejecting a contained substance or object (a PIT tag) through the needle 24 into the body tissue or cavity.
  • a radiologist using one or ore of the above-referenced imaging techniques, usually determines the region or location of interest, that is, the * tissue, volume of tissue, growth, tumor, gland or object to be surgically removed from the
  • one or more PIT elements or tags 10 can be implanted in the body at, adjacent, or in proximity to the target by injection via the syringe 20 or other implanter or deployment needle or device.
  • the PIT element has a size range of 1 millimeter in diameter to 5 millimeters in diameter, with 2-3 millimeters being preferred, and a length of 2-30 millimeters, with 8-12 millimeters being preferred.
  • a syringe for example, can be loaded with a PIT
  • each PIT element is pre-loaded into an implanter, gas sterilized, and individually packaged for subsequent use.
  • a reader or scanner 30 capable of locating and detecting PIT elements or tags 10 implanted in a body is depicted illustratively in Fig. 3.
  • the system employed in practice of the invention is preferably a radio frequency identification system.
  • Radio frequency identification uses a signal transmitted between an electronic device such as a PIT element and a reading device such as a scanner or reader or transceiver.
  • RFID technology identifies objects remotely through the use of radio frequencies.
  • RFID is used to locate and identify a PIT element that has been implanted into a patient who will undergo surgery to remove the target tissue, organ or object.
  • the scanner can, with relative ease, detect PIT elements embedded up to 7-10 centimeters deep in a body and give the approximate location
  • the scanner/reader 30 illustrated is hand held and battery operated, and contains a radio frequency transmitter and receiver (transceiver), an on/off control button 32 and an LCD read-out screen 34 for displaying the unique code pre-recorded in the microchip of each PIT tag.
  • a RFID scanner/reader suitable for practice of the invention is available from Destron-Fearing Corporation.
  • PIT elements, sterile tag implanter packages, and scanners can be obtained from the Biomark Corporation of Boise, Idaho. These systems have been used to tag, track and identify animals by injecting subcutaneous PTT elements under the animal's skin. However they have not been used in the healthcare field for passively locating suspect tissue and/or foreign objects in a body and for aiding in the performance of surgical procedures to remove malignancies, diseased organs and the like.
  • radiological techniques such as X- ray, ultra sound and/or magnetic resonance imaging, may be employed to locate targets, that is, suspect tissue, diseased organs, tumors, foreign objects, etc., in a body.
  • a radiologist using one or more PIT tags and tag implanters, then marks the location by deploying and implanting one or more tags in the body adjacent or contiguous to the suspect tissue or organ.
  • Two or more tags may, for example, be implanted to bracket, or to outline or delineate the boundaries of, a malignancy, tumor or the like. Once implanted, the tag or tags will maintain their position in the body and will not migrate or be displaced from the location of deployment even though surgery may be delayed for hours or even days. Since the PIT tags are sterile and remain passive until
  • the scanner control button 32 When the patient is taken to the operating room and prepared for surgery, the scanner control button 32 is depressed and the scanner 30 is passed over the patient's body. A radio frequency signal generated by the scanner activates each PIT element when the scanner is within 7-10 centimeters of the element, and a unique alpha numeric character string is then displayed on the LCD screen 34 that identifies the PIT tag.
  • the display on the screen also serves to notify the surgeon of the location in the patient's body of the detected PIT element, i.e., proximate the position of the scanner.
  • the display may also be accompanied by an audible tone denoting the location of the detected element or tag.
  • a surgeon can, if he or she wishes to do so, then use the scanner or RFID energized elements as markers for excising a target tissue, organ or object. For many surgeries, this is an advantageous practice and constitutes one aspect of the invention.
  • a grid dip oscillator 40 illustrated in Figs. 4 and 5 is brought into use.
  • a grid dip meter is an oscillator whose output energy changes in the
  • a grid dip meter is suitably embodied in a hand held battery operated oscillator or transceiver 40 for transmitting a signal to and receiving a responsive signal from the PIT element or elements implanted in a patient's body.
  • the transmitted signal energizes the transponder in the PIT element and causes it to emit an electromagnetic field, as depicted illustratively at 50 in Fig. 5.
  • the oscillator 40 measures the amount of electromagnetic energy in the field and includes, in a preferred embodiment, a visible graduated display or reading device 42 for visually displaying the sensed value of the electromagnetic field and a
  • tone generator with speaker 44 for emitting a tone signal as- -a function of the sensed magnitude of the electromagnetic field of the PIT element.
  • the sound projected by the speaker may change in volume or pitch corresponding to the magnitude of the PIT signal.
  • a grid dip oscillator preferred for use as a PIT locating device or detection apparatus in practice of the invention, is available from Antenna & Microwave Technologies, Salisbury, South Australia 5108, Australia.
  • the user e.g., the surgeon or a surgical assistant, passes or sweeps the oscillator over the patient's body and when the oscillator is brought into proximity to a PIT element, a visible indication will appear on the reader 42 and/or a sound will be emitted by the speaker 44. Then, by moving the oscillator back and forth and/or circularly over the region of the body from which he signal was emitted, the visual display on the reader will move up and down and/or the audible sound will increase and decrease in volume or pitch until a position is reached where the reading
  • the detection and locating apparatus or oscillator 40 also enables the user/surgeon to determine the orientation of each PIT element in the patient's body.
  • the locator apparatus or oscillator 40 is useful not only in pre-incision analysis of the patient to be operated upon, but is most useful during performance of the surgery itself.
  • the unit 40 may be used externally of the body to guide the surgery and may also be sterilized and/or surgically draped for insertion directly into an incision for purposes of providing guidance to the- surgeon for precise excision of a target tissue, volume of tissue, organ or object.
  • the excision preferably follows the distal side of the tag (the side of the tag opposite the side that is proximate the tissue) so that the tag or tags constitute part of the excised matter.
  • the scanner 30 and/or the oscillator 40 can be energized and passed over the excised matter for the presence of PIT signals, thereby to determine whether the tag or tags have been excised with the matter, and/or the scanner or the oscillator can be passed over the area where surgery was performed for the absence of PIT signals, thereby to determine whether all of the marked tissue was in fact excised.
  • This feature of the invention may, if desired, be used in conjunction with other locating systems, such as hookwires, to insure thorough excision of target tissue.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Human Computer Interaction (AREA)
  • Electromagnetism (AREA)
  • Prostheses (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne un procédé utilisé pour le retrait chirurgical d'un organisme de tissus suspects, d'organes lésés et/ou de corps étrangers et consistant à implanter à l'intérieur de l'organisme avant l'intervention chirurgicale une ou plusieurs étiquettes répondeuses intégrées passives à proximité du tissu suspect ou de l'objet, puis, au moment de et/ou pendant l'intervention, à balayer l'organisme avec un scanner à radiofréquence ou un lecteur qui active les étiquettes et fournit au chirurgien un ou plusieurs signaux indiquant l'emplacement de chaque étiquette et les identifiant. Un appareil de mesure d'inclinaison de grille est utilisé pendant l'intervention pour localiser précisément les étiquettes, et donc aider le chirurgien. Une vérification de l'intervention est réalisée ensuite en balayant le site pour y confirmer l'absence des étiquettes et/ou en balayant le tissu excisé pour y vérifier la présence des étiquettes.
PCT/US2007/008331 2006-04-05 2007-04-05 processus chirurgicaux WO2007117478A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78912406P 2006-04-05 2006-04-05
US60/789,124 2006-04-05
PCT/US2007/002313 WO2007087447A2 (fr) 2006-01-25 2007-01-25 Procedure chirurgicale
USPCT/US2007/02313 2007-01-25

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WO2007117478A2 true WO2007117478A2 (fr) 2007-10-18
WO2007117478A3 WO2007117478A3 (fr) 2008-09-12

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Cited By (14)

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GB2451890A (en) * 2007-08-17 2009-02-18 Lancaster University Position and orientation detector
WO2009043512A1 (fr) * 2007-09-26 2009-04-09 Amedo Smart Tracking Solutions Gmbh Marqueur de tissu
WO2010151843A3 (fr) * 2009-06-26 2011-02-17 Cianna Medical, Inc. Appareils, systèmes et méthodes permettant de localiser des marqueurs ou des structures de tissu dans un corps
US8939153B1 (en) 2013-03-15 2015-01-27 Health Beacons, Inc. Transponder strings
US8973584B2 (en) 2009-02-13 2015-03-10 Health Beacons, Inc. Method and apparatus for locating passive integrated transponder tags
US9386942B2 (en) 2009-06-26 2016-07-12 Cianna Medical, Inc. Apparatus, systems, and methods for localizing markers or tissue structures within a body
US9713437B2 (en) 2013-01-26 2017-07-25 Cianna Medical, Inc. Microwave antenna apparatus, systems, and methods for localizing markers or tissue structures within a body
US10188310B2 (en) 2014-08-24 2019-01-29 Health Beacons, Inc. Probe for determining magnetic marker locations
US10610326B2 (en) 2015-06-05 2020-04-07 Cianna Medical, Inc. Passive tags, and systems and methods for using them
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