US20030229010A1 - Oral insulin-oligomer conjugates - Google Patents
Oral insulin-oligomer conjugates Download PDFInfo
- Publication number
- US20030229010A1 US20030229010A1 US10/448,535 US44853503A US2003229010A1 US 20030229010 A1 US20030229010 A1 US 20030229010A1 US 44853503 A US44853503 A US 44853503A US 2003229010 A1 US2003229010 A1 US 2003229010A1
- Authority
- US
- United States
- Prior art keywords
- insulin
- polymer
- conjugate
- microemulsion
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 [H]CC(=O)*C[C@@H]1COC(C(C)C)[C@H]1C Chemical compound [H]CC(=O)*C[C@@H]1COC(C(C)C)[C@H]1C 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N CC(=O)O Chemical compound CC(=O)O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- MSRUUHHHOIFFFY-YVDFIBJFSA-N B.C.C.C.C.C.C.CC.CC.CC.CC.CC.CC(=O)C(C)C.CC(=O)C(C)C.CC(C)=O.CC(C)=O.CC(N)=O.CC=O.CCC(C)(C)C(C)C1OC[C@@H](C(C)=O)[C@@H]1C.CNC=O.COC(N)=O.COC=O.[2HH] Chemical compound B.C.C.C.C.C.C.CC.CC.CC.CC.CC.CC(=O)C(C)C.CC(=O)C(C)C.CC(C)=O.CC(C)=O.CC(N)=O.CC=O.CCC(C)(C)C(C)C1OC[C@@H](C(C)=O)[C@@H]1C.CNC=O.COC(N)=O.COC=O.[2HH] MSRUUHHHOIFFFY-YVDFIBJFSA-N 0.000 description 1
- SNKLIQISRASLDM-UHFFFAOYSA-N C.C.C.C.C.C.C.CC(=O)C(C)C.CC(=O)C(C)C.CC(=O)CC(C)C.CC(C)=O.CC(C)=O.CC(C)=O.CC(N)=O.CNC=O.COC(N)=O.COC=O.F.[HH] Chemical compound C.C.C.C.C.C.C.CC(=O)C(C)C.CC(=O)C(C)C.CC(=O)CC(C)C.CC(C)=O.CC(C)=O.CC(C)=O.CC(N)=O.CNC=O.COC(N)=O.COC=O.F.[HH] SNKLIQISRASLDM-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N C=O Chemical compound C=O WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- LEBOWOQNEVHIDX-UHFFFAOYSA-N C=O.CC=O.CCO.CCO.[NaH] Chemical compound C=O.CC=O.CCO.CCO.[NaH] LEBOWOQNEVHIDX-UHFFFAOYSA-N 0.000 description 1
- PKQIDSVLSKFZQC-UHFFFAOYSA-N CC(=O)CC=O Chemical compound CC(=O)CC=O PKQIDSVLSKFZQC-UHFFFAOYSA-N 0.000 description 1
- FXDRWCODSKWZMN-UHFFFAOYSA-N CC(=O)NCC(O)CO.CC(=O)OCC(O)CO.CC(O)CO.CC(O)CO Chemical compound CC(=O)NCC(O)CO.CC(=O)OCC(O)CO.CC(O)CO.CC(O)CO FXDRWCODSKWZMN-UHFFFAOYSA-N 0.000 description 1
- COGWWGSKZTZDIZ-ZKBGWCBYSA-N CC(=O)OCC(C)C1OC[C@@H](CO)[C@@H]1C.CC(=O)OCC(O)C1OC[C@@H](O)[C@@H]1O.COC[C@@H]1COC(C(C)COC(C)=O)[C@H]1C.[NaH] Chemical compound CC(=O)OCC(C)C1OC[C@@H](CO)[C@@H]1C.CC(=O)OCC(O)C1OC[C@@H](O)[C@@H]1O.COC[C@@H]1COC(C(C)COC(C)=O)[C@H]1C.[NaH] COGWWGSKZTZDIZ-ZKBGWCBYSA-N 0.000 description 1
- RDXBEUYXYAHMCO-HOXAQBHYSA-N CC(=O)OCC(C)C1OC[C@@H](O)[C@@H]1C.CC(=O)OCC(C)C1OC[C@@H](O)[C@@H]1O Chemical compound CC(=O)OCC(C)C1OC[C@@H](O)[C@@H]1C.CC(=O)OCC(C)C1OC[C@@H](O)[C@@H]1O RDXBEUYXYAHMCO-HOXAQBHYSA-N 0.000 description 1
- BQLDVSROXZYQMG-RRABCLCVSA-N CC(=O)OCC(O)C1OC[C@@H](O)[C@@H]1O Chemical compound CC(=O)OCC(O)C1OC[C@@H](O)[C@@H]1O BQLDVSROXZYQMG-RRABCLCVSA-N 0.000 description 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N CC(C)=O Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 1
- NBVULSYHIKXKRT-UHFFFAOYSA-N CC(C)C.CC(C)CO Chemical compound CC(C)C.CC(C)CO NBVULSYHIKXKRT-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N CCC(=O)O Chemical compound CCC(=O)O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- CSXHGOMTANHOQG-MXAZLMSGSA-N CCC(C)C1OC[C@@H](C)[C@@H]1C Chemical compound CCC(C)C1OC[C@@H](C)[C@@H]1C CSXHGOMTANHOQG-MXAZLMSGSA-N 0.000 description 1
- DKXLHDJUOZPENX-UHFFFAOYSA-N NCC(O)CO.OCC(O)CO Chemical compound NCC(O)CO.OCC(O)CO DKXLHDJUOZPENX-UHFFFAOYSA-N 0.000 description 1
- FTZSRVSRWKGJHB-UHFFFAOYSA-N O=C(O[CH-]P)OC1=CC=C([N+](=O)[O-])C=C1.O=CO[CH-]P Chemical compound O=C(O[CH-]P)OC1=CC=C([N+](=O)[O-])C=C1.O=CO[CH-]P FTZSRVSRWKGJHB-UHFFFAOYSA-N 0.000 description 1
- MPMYQQHEHYDOCL-UHFFFAOYSA-N [NaH] Chemical compound [NaH] MPMYQQHEHYDOCL-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/448,535 US20030229010A1 (en) | 1993-05-10 | 2003-06-02 | Oral insulin-oligomer conjugates |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/059,701 US5359030A (en) | 1993-05-10 | 1993-05-10 | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US08/276,890 US5438040A (en) | 1993-05-10 | 1994-07-19 | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US08/509,422 US5681811A (en) | 1993-05-10 | 1995-07-31 | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
US08/958,383 US6191105B1 (en) | 1993-05-10 | 1997-10-27 | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
US61420300A | 2000-07-12 | 2000-07-12 | |
US10/448,535 US20030229010A1 (en) | 1993-05-10 | 2003-06-02 | Oral insulin-oligomer conjugates |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US61420300A Continuation | 1993-05-10 | 2000-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20030229010A1 true US20030229010A1 (en) | 2003-12-11 |
Family
ID=27369707
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/958,383 Expired - Fee Related US6191105B1 (en) | 1993-05-10 | 1997-10-27 | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
US10/448,524 Abandoned US20030229006A1 (en) | 1993-05-10 | 2003-05-30 | Amphiphilic oligomers |
US10/448,535 Abandoned US20030229010A1 (en) | 1993-05-10 | 2003-06-02 | Oral insulin-oligomer conjugates |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/958,383 Expired - Fee Related US6191105B1 (en) | 1993-05-10 | 1997-10-27 | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
US10/448,524 Abandoned US20030229006A1 (en) | 1993-05-10 | 2003-05-30 | Amphiphilic oligomers |
Country Status (1)
Country | Link |
---|---|
US (3) | US6191105B1 (US20030229010A1-20031211-C00007.png) |
Cited By (10)
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US20040203081A1 (en) * | 2002-11-26 | 2004-10-14 | James Kenneth D. | Natriuretic compounds, conjugates, and uses thereof |
US20080021005A1 (en) * | 2004-04-01 | 2008-01-24 | Cardiome Pharma Corp. | Pegylated Ion Channel Modulating Compounds |
US20080139392A1 (en) * | 2006-12-12 | 2008-06-12 | Edgar Joel Acosta-Zara | Linker-Based Lecithin Microemulsion Delivery Vehicles |
US20080207505A1 (en) * | 2005-01-12 | 2008-08-28 | James Kenneth D | Bna Conjugates and Methods of Use |
US20090036353A1 (en) * | 2005-01-27 | 2009-02-05 | Novo Nordisk A/S | Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers |
US20090176691A1 (en) * | 2007-12-19 | 2009-07-09 | Farid Bennis | Pharmaceutical Compositions Containing at Least One Protein Active Ingredient Protected From Digestive Enzymes |
US7651996B2 (en) | 2003-12-08 | 2010-01-26 | Cpex Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for insulin treatment |
WO2010059204A1 (en) * | 2008-11-18 | 2010-05-27 | University Of Medicine And Dentistry Of New Jersey | Methods and compositions for treating obesity and related disorders |
US9260501B2 (en) | 2006-10-27 | 2016-02-16 | Novo Nordisk A/S | Peptide extended insulins |
US9682153B2 (en) | 2008-09-19 | 2017-06-20 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
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US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
GB9819382D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
US7105154B2 (en) * | 2000-07-19 | 2006-09-12 | Pepgen Corporation | Method of treatment using interferon-tau |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
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US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
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US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
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US20090036353A1 (en) * | 2005-01-27 | 2009-02-05 | Novo Nordisk A/S | Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers |
US9260501B2 (en) | 2006-10-27 | 2016-02-16 | Novo Nordisk A/S | Peptide extended insulins |
US20080139392A1 (en) * | 2006-12-12 | 2008-06-12 | Edgar Joel Acosta-Zara | Linker-Based Lecithin Microemulsion Delivery Vehicles |
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Also Published As
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US6191105B1 (en) | 2001-02-20 |
US20030229006A1 (en) | 2003-12-11 |
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