US20030078551A1 - Atomizer for applying liquids onto eyes - Google Patents

Atomizer for applying liquids onto eyes Download PDF

Info

Publication number
US20030078551A1
US20030078551A1 US10/185,949 US18594902A US2003078551A1 US 20030078551 A1 US20030078551 A1 US 20030078551A1 US 18594902 A US18594902 A US 18594902A US 2003078551 A1 US2003078551 A1 US 2003078551A1
Authority
US
United States
Prior art keywords
eye
nozzle
atomizer
adapter
housing part
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/185,949
Other languages
English (en)
Inventor
Dieter Hochrainer
Bernd Zierenberg
Michael Diestelhorst
Isolde Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to US10/185,949 priority Critical patent/US20030078551A1/en
Assigned to BOEHRINGER INGELHEIM PHARMA KG reassignment BOEHRINGER INGELHEIM PHARMA KG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ZIERENBERG, BERND, DIESTELHORST, MICHAEL, MARTIN, ISOLDE, HOCHRAINER, DIETER
Publication of US20030078551A1 publication Critical patent/US20030078551A1/en
Priority to US10/601,737 priority patent/US20040010239A1/en
Priority to US11/457,506 priority patent/US7314187B2/en
Priority to US11/958,619 priority patent/US20080097359A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/108—Means for counting the number of dispensing strokes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H35/00—Baths for specific parts of the body
    • A61H35/02—Baths for specific parts of the body for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/008—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised by squeezing, e.g. using a flexible bottle or a bulb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7722—Line condition change responsive valves
    • Y10T137/7837—Direct response valves [i.e., check valve type]
    • Y10T137/7904—Reciprocating valves
    • Y10T137/7908—Weight biased
    • Y10T137/7909—Valve body is the weight
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7722—Line condition change responsive valves
    • Y10T137/7837—Direct response valves [i.e., check valve type]
    • Y10T137/7904—Reciprocating valves
    • Y10T137/7908—Weight biased
    • Y10T137/7909—Valve body is the weight
    • Y10T137/7913—Guided head
    • Y10T137/7915—Guide stem
    • Y10T137/7916—With closing stop

Definitions

  • the present invention relates to atomisers for applying liquids to the cornea of the eye or to the connective tissue of the eye, special eye adapters for atomizers and the use of atomizers for ophthalmological administration.
  • the atomizers according to the invention are free from propellant gas and have an energy reservoir for supplying the energy required for the atomizing process.
  • aqueous eye drops For treating dry eyes, for moistening the surface of the eye for contact lens wearers, for numerous eye diseases or methods of investigating the eye it is usual to administer medicaments in the form of an aqueous formulation as eye drops.
  • liquid dispensers have been developed in which the formulation is supplied from a storage bottle through a dropper, for example (dropper bottles or EDO-Ophthiols).
  • the aqueous formulation usually flows out of the dropper opening as a result of manual pressure being applied to the compressible storage bottle.
  • a drop forms on the opening, which does not break away from the dropper and drop into the eye until a certain relationship is reached between the size of the dropper opening, the surface tension and the weight of the drop.
  • aqueous eye drops have a volume of about 0.05 ml.
  • a further disadvantage is that the formulation administered is initially only applied to one point on the cornea, which feels unpleasant, not only because of the local pressure produced on the surface of the eye.
  • the surface of the eye is coated with about 7 microlitres of a film of liquid. Any application of an additional liquid consequently causes some of the total liquid on the eye to flow away through the tear duct. This naturally occurs particularly when larger amounts of liquid, such as e.g. 40 microlitres or more of eye drops are applied. If a pharmacologically effective liquid enters the tear duct, it can be absorbed systemically by the body, i.e. the pharmacologically active ingredients are absorbed directly by the body. This may lead to allergic or toxicological effects. In conventional applications about 80% of the liquid administered is displaced out of the eye and some of it enters the tear duct.
  • Another disadvantage of this method is that there may be short-term irritation of the eyes at the site where the drops are instilled.
  • the conventional application devices are also not protected against the entry of germs into the formulation for administration, which means that preservatives have to be added to the formulations.
  • Preservatives may lead to chronic inflammation of the conjunctiva or the underlying Tenon's membrane in long-term or chronic use.
  • U.S. Pat. No. 5,588,564 discloses a pump spray provided with an adapter for administering a spray jet to the eye.
  • an adapter for administering a spray jet to the eye.
  • the spray duration of this system is short, there is a danger that the solution will not be sprayed onto the eye but onto the eyelid, as a result of the blink reflex.
  • Neither the pump spray nor the adapter has means for protecting the eye from possible injury by the comparatively hard spray jet.
  • U.S. Pat. No. 5,921,444 discloses a spray device with a fitting for administering a liquid to an eye.
  • the disadvantages of this system are similar to those described above.
  • WO 96/00050 discloses an applicator for applying liquids to an eye, wherein the spray device is located within a housing one side of which is constructed so that it can fit round an eye.
  • the aerosol droplets produced with the device have a diameter of at least 20 micrometres.
  • the spray duration of this system is less than ⁇ fraction (1/20) ⁇ th of a second (page 13), which has the disadvantages described above.
  • EP 0911056 discloses an atomizer for placing over an eye with an adapter which has a shutter or deflector plate positioned so that the spray jet does not strike the cornea directly.
  • a protector of this kind will become dirty very quickly and is difficult to clean and on the other hand it militates against exact and reproducible metering.
  • the problem on which the present invention is based is to apply aqueous solutions or ophthalmologically effective formulations by means of a single form of application to the surface of the eye in such a way as to reduce the local irritation of one area of the cornea compared with conventional methods of applying eye drops.
  • Another problem is to develop a process with which eye drops can be administered in a manner which is more pleasant for the user than is known from the prior art.
  • Another problem is to develop a process in which the liquid to be administered can be applied uniformly over the eye.
  • Another problem of the invention is to minimise overdosing.
  • Yet another objective is to minimise the risk of injury to the eye during application of the eye drops.
  • the present invention solves this problem by providing atomizers which convert a small amount of the comparatively highly concentrated formulation to be applied through a nozzle into a soft spray mist with small particle sizes and travelling at low speed and bring this spray mist into contact with the surface of the eye.
  • the atomizers according to the invention comprise, close to the nozzle from which the spray mist emerges, an adapter which fixes the distance from the nozzle to the eye and prevents the aerosol cloud from being blown away by wind.
  • the particles leaving the nozzle of the atomizer must not exceed a certain mass and velocity, or the atomizer and adapter must be constructed so that the speed of the droplets leaving the nozzle is reduced accordingly, as they travel from the nozzle to the eye.
  • a spray duration of at least 0.5 seconds, preferably at least 1 second, is also important, as this spreads the force of the droplets hitting the eye over a longer period, thus reducing it, and any blinking that may occur during this period will keep only a comparatively small proportion of the cloud of droplets away from the eye.
  • the upper limit of the force of the cloud of droplets hitting the eye should not exceed 5 milliNewtons, preferably 2.5 milliNewtons.
  • the force is on average less than 0.5 milliNewtons and more preferably less than 0.05 milliNewtons.
  • the process according to the invention produces a spray mist which corresponds to an aerosol of water droplets with an average diameter of about 2 to 20 microns.
  • the forces specified correspond to a pulse of the particles with an upper limit of less than 5*10 ( ⁇ circle over ( ) ⁇ 4) kilogram*metre per second (within the scope of the present specification the symbol ⁇ circle over ( ) ⁇ denotes the mathematical term written as a superscript, i.e. for example 10 ( ⁇ circle over ( ) ⁇ 2) represents 0.01, etc.).
  • the pulse is on average between 10 ( ⁇ circle over ( ) ⁇ 4) kilogram*metre per second and 10 ( ⁇ circle over ( ) ⁇ 10) kilogram*metre per second, more preferably not more than 5*10 ( ⁇ circle over ( ) ⁇ 5) kilogram*metre per second, specifically 5*10 ( ⁇ circle over ( ) ⁇ 7) kilogram*metre per second.
  • a soft spray mist is produced by the process according to the invention which corresponds to an aerosol of water droplets with a mean diameter of about 1-15 microns.
  • the preferred particle size of the aerosol is 1 to 10 microns, more preferably 3 to 8 microns. All the data relating to the particle size relates to the average particle size in the form of the average aerodynamic diameter.
  • the aerodynamic diameter is meant the kinetic diameter of a gas particle or, as in this case, an aerosol droplet, which corresponds to the diameter of a sphere with a density of 1 g cm ⁇ 3 , which, under the effect of external mechanical forces in equilibrium, has the same speed of migration relative to the dispersing agent (gas or air in this case) as the particles under investigation.
  • the aerosol cloud meets the surface of the eye at a distance from the nozzle of 1 to 5 cm, preferably 1 to 3 cm, most preferably 1.5 to 2.5 cm.
  • the applicator according to the invention is an atomizer comprising an adapter around its nozzle for placing over the eye.
  • the adapter is a cavity surrounded by a wall with two openings.
  • One opening surrounds the nozzle of the atomizer so that a spray jet leaving the nozzle is conveyed exclusively into the cavity.
  • the nozzle is centrally arranged within the opening.
  • the spray jet leaves the cavity to make contact with the eye.
  • the outer contour of the second opening is preferably constructed so that it surrounds the visible part of the human eye, preferably without pressing on the surface of the eye.
  • this second opening is preferably of the following configuration, if the adapter is connected to the atomizer:
  • the openings of the adapter are round to oval in shape.
  • the opening closest to the eye is shaped so as to surround the eye entirely, i.e. one part of the opening is longer than the other.
  • the opening thus takes the form of a concave line one end of which is at a greater spacing from the nozzle than the other end.
  • the adapter is a funnel-shaped tube with two opposite openings, the opening on the tapering side surrounding the nozzle of the atomizer and thus being surrounded by the nozzle opening of the adapter.
  • the opening on the other side of the adapter is large enough to fit round the outer contour of an eye.
  • the adapter may be permanently connected to the atomizer via the first opening, e.g. if the edge of this opening is welded onto part of the inhaler or if the casing of the atomizer and the adapter constitute a single component.
  • the adapter is then an integral part of the atomizer and this first opening is then in practice only a non-open part of the atomizer.
  • the adapter may also be constructed as a detachable element.
  • the atomizer may have, close to the nozzle, one or more projections onto which the adapter can be fitted over the first opening.
  • a projection may be, for example, a ring surrounding the nozzle with a height ranging from a few mm to a few cm (up to 5 cm), preferably with a height from 1-2.5 cm.
  • the side of the adapter attached to the atomizer may be constructed so that it can be fitted directly onto the nozzle holder or is fixed to another element in the vicinity of the nozzle.
  • the other end of the adapter is constructed so that it can be placed on a person's face in such a way as to completely surround the visible part of the eye while covering as little of the skin of the face as possible. This ensures that the majority of the spray mist reaches the surface of the eye without wetting the facial skin very much.
  • the opening on this side of the adapter is oval.
  • openings may optionally be formed in the side wall of the adapter through which excess spray mist can escape. These openings preferably have a diameter of up to 1 cm, more preferably up to 0.5 cm.
  • the adapter is designed so that it cannot damage the face or the eye.
  • preferred atomizers are those wherein a quantity of less than 100 microlitres, preferably less than 50 microlitres, most preferably less than 20 microlitres of active substance solution can be atomized by preferably one actuation to form an aerosol with an average particle size of less than 20 microns, preferably less than 10 microns.
  • atomizers as designated by the trade mark Respimat® are used.
  • the method according to the invention is characterised inter alia in that the quantity of formulation to be administered can be restricted to a few microlitres.
  • An apparatus of this kind for propellant-free atomizing of a metered amount of a liquid pharmaceutical composition is described in detail, for example, in International Patent Application WO 91/14468 “Atomizing Device and Methods” and also in WO 97/12687, cf. FIGS. 6 a and 6 b and the associated description.
  • a pharmaceutical solution is converted into an aerosol with an average particle size (average aerodynamic diameter) of less than 20 microns, and sprayed, by the application of high pressures of up to 500 bar.
  • the solution formulations are stored in a reservoir. It is essential that the formulations of active substance used are sufficiently stable when stored and at the same time are of a nature such that they can be administered directly for the medical purpose in question, if possible without any further manipulation. Moreover, they should not contain any ingredients which could interact with the atomizer in such a way that the atomizer or the pharmaceutical quality of the solution, or of the aerosol produced, might be harmed.
  • the preferred atomizer essentially consists of an upper housing part, a pump housing, a nozzle, an adapter, a locking mechanism, a spring housing, a spring and a storage container, the outstanding features of the atomizer being:
  • a pump housing which is secured in the upper housing part and which comprises at one end a nozzle body with the nozzle or nozzle arrangement,
  • a power takeoff flange in which the hollow plunger is secured and which is located in the upper housing part
  • a spring housing with the spring contained therein which is rotatably mounted on the upper housing part by means of a rotary bearing,
  • an adapter in the form of a cavity with two opposite openings, the smaller opening closely surrounding at least the point of emergence of the aerosol from the nozzle and the larger opening having a contour which enables this opening to be fitted over an eye.
  • the hollow plunger with valve body corresponds to a device disclosed in WO 97/12687. It projects partially into the cylinder of the pump housing and is axially movable within the cylinder. Reference is made in particular to FIGS. 1 to 4 , especially FIG. 3, and the relevant parts of the description.
  • the hollow plunger with valve body exerts a pressure of 5 to 60 MPa (about 50 to 600 bar), preferably 10 to 60 MPa (about 100 to 600 bar) on the fluid, comprising the measured amount of active substance solution, at its high pressure end at the moment when the spring is actuated. Volumes of 10 to 50 microlitres are preferred, while volumes of 5 to 20 microlitres are particularly preferred and a volume of 15 microlitres per spray is most particularly preferred.
  • valve body is preferably mounted at the end of the hollow plunger facing the valve body.
  • the nozzle in the nozzle body is preferably microstructured, i.e. produced by microtechnology.
  • Microstructured valve bodies are disclosed for example in WO-94/07607; reference is hereby made to the contents of this specification, particularly FIG. 1 therein and the associated description.
  • the nozzle body consists for example of two sheets of glass and/or silicon firmly joined together, at least one of which has one or more microstructured channels which connect the nozzle inlet end to the nozzle outlet end.
  • the directions of spraying of the nozzles in the nozzle body may extend parallel to one another or may be inclined relative to one another in the direction of the nozzle opening.
  • the directions of spraying may be at an angle of 20 to 160° to one another, preferably 60 to 150°, most preferably 80 to 100°.
  • the nozzle openings are preferably arranged at a spacing of 10 to 200 microns, more preferably at a spacing of 10 to 100 microns, most preferably 20 to 50 microns. Spacings of 22 to 28 microns are most preferred. The jets will therefore meet directly in front of the nozzle openings.
  • the liquid pharmaceutical preparation is under an entry pressure of up to 600 bar, preferably 200 to 300 bar, at the entry to the nozzle body and is atomized into an inhalable aerosol through the nozzle openings.
  • the preferred particle sizes of the aerosol are up to 20 microns, preferably 3 to 10 microns.
  • the locking mechanism contains a spring, preferably a cylindrical helical compression spring, as a store for the mechanical energy.
  • the spring acts on the power takeoff flange as an actuating member the movement of which is determined by the position of a locking member.
  • the travel of the power takeoff flange is precisely limited through two stops.
  • the spring is preferably biased, via a power step-up gear, e.g. a helical thrust gear, by an external torque which is produced when the upper housing part is rotated counter to the spring housing in the lower housing part.
  • the upper housing part and the power takeoff flange have a single or multiple V-shaped gear.
  • the locking member with engaging locking surfaces is arranged in a ring around the power takeoff flange. It consists, for example, of a movable, mouldable ring of plastic or metal. The ring is arranged in a plane at right angles to the atomizer axis. After the biasing of the spring, the locking surfaces of the locking member move into the path of the power takeoff flange and prevent the spring from relaxing.
  • the locking member is actuated by means of a button.
  • the actuating button is connected or coupled to the locking member. In order to actuate the locking mechanism, the actuating button is moved parallel to the annular plane, preferably into the atomizer; this causes the ring to move in the annular plane. Details of the construction of the locking mechanism are given in WO 97/20590.
  • the lower housing part is pushed axially over the spring housing and covers the mounting, the drive of the spindle and the storage container for the fluid.
  • the upper housing part When the atomizer is actuated the upper housing part is rotated relative to the lower housing part, the lower housing part taking the spring housing with it.
  • the spring is thereby compressed and biased by means of the helical thrust gear and the locking mechanism engages automatically.
  • the angle of rotation is preferably a whole-number fraction of 360 degrees, e.g. 180 degrees.
  • the power takeoff part in the upper housing part is moved along by a given distance, the hollow plunger is withdrawn inside the cylinder in the pump housing, as a result of which some of the fluid is sucked out of the storage container and into the high pressure chamber in front of the nozzle.
  • a number of exchangeable storage containers which contain the fluid to be atomized may be pushed into the atomizer one after another and used in succession.
  • the storage container contains the aqueous aerosol preparation according to the invention.
  • the atomizing process is initiated by pressing gently on the actuating button.
  • the locking mechanism opens up the path for the power takeoff member.
  • the biased spring pushes the plunger into the cylinder of the pump housing.
  • the fluid leaves the nozzle of the atomizer in atomized form.
  • Some of the elements of the atomizer which come into contact with the liquid being administered as it travels from the storage container to the nozzle may optionally be made of oligodynamically active ingredients or may be coated with germicidal materials. Alternatively or in addition, a germ-repellent filter may be formed in this pathway.
  • the components of the atomizer are made of a material which is suitable for its purpose.
  • the housing of the atomizer and, if its operation permits, other parts as well are preferably made of plastics, e.g. by injection moulding. For medicinal purposes, physiologically safe materials are used.
  • FIG. 1 diagrammatically shows an adapter ( 1 ) the lower part ( 2 ) of which is placed on one or more projections disposed in a circular to elliptical arrangement surrounding the nozzle or is fixedly connected thereto.
  • the other end of the adapter ( 3 ) is constructed so that it can be fitted over the eye socket like a negative.
  • the adapter may be of a kind in which the pulse of the particles of spray mist is reduced, particularly wherein the speed of the particles is reduced.
  • FIGS. 2 and 3 show the atomizer with which the aqueous ophthalmological aerosol preparations may advantageously be administered to the eye.
  • FIG. 2 shows a longitudinal section through the atomizer with the spring biased
  • FIG. 3 shows a longitudinal section through the atomizer with the spring relaxed.
  • the upper housing part ( 9 ) contains the pump housing ( 10 ) on the end of which is mounted the holder ( 11 ) for the atomizer nozzle.
  • the holder In the holder is the nozzle body ( 12 ) and a filter ( 13 ).
  • the hollow plunger ( 15 ) fixed in the power takeoff flange ( 14 ) of the locking mechanism projects partially into the cylinder of the pump housing.
  • the hollow plunger At its end the hollow plunger carries the valve body ( 16 ).
  • the hollow plunger is sealed off by means of the seal ( 17 ).
  • the stop ( 18 ) Inside the upper housing part is the stop ( 18 ) on which the power takeoff flange abuts when the spring is relaxed.
  • the locking member ( 20 ) moves between the stop ( 19 ) and a support ( 21 ) in the upper housing part.
  • the actuating button ( 22 ) is connected to the locking member.
  • the upper housing part ends in the outlet aperture ( 23 ) on which the adapter ( 1 ) is placed with its small opening ( 2 ). Close to the opening ( 3 ) which faces the eye during use, air vents ( 24 ) are provided.
  • the open side of the adapter can be closed off by a cover which completely surrounds the openings ( 3 ) and ( 24 ) from the outside or inside, as selected (not shown).
  • the spring housing ( 25 ) with compression spring ( 26 ) is rotatably mounted on the upper housing part by means of the snap-in lugs ( 27 ) and rotary bearing.
  • the lower housing part ( 28 ) is pushed over the spring housing.
  • Inside the spring housing is the exchangeable storage container ( 29 ) for the fluid ( 30 ) which is to be atomized.
  • the storage container is sealed off by the stopper ( 31 ) through which the hollow plunger projects into the storage container and is immersed at its end in the fluid (supply of active substance solution).
  • the spindle ( 32 ) for the mechanical counter is mounted in the covering of the spring housing. At the end of the spindle facing the upper housing part is the drive pinion ( 33 ). The slider ( 34 ) sits on the spindle.
  • the atomizer described above is suitable for atomizing the ophthalmological aerosol preparations to produce an aerosol suitable for administration to the eye.
  • any known ophthalmologically active formulations are suitable as the formulation which may be administered using the atomizers according to the invention. These formulations may also differ from the prior art in that the active substances may be more highly concentrated if desired. As mentioned hereinbefore, the quantity of formulation to be administered may be reduced by the process according to the invention from about 50 microlitres in the case of the devices known from the prior art to about 10-20 microlitres or less. This means that the active substance formulations may be about five times more concentrated as a result of the process according to the invention.
  • the formulation is simply water (water for injections) or isotonic water or other agents for moistening the eye. In other words, there is no pharmacologically active substance present.
  • Suitable co-solvents may be, inter alia, ethanol, polyethyleneglycols, polypropyleneglycols, ethyleneglycols and propyleneglycols.
  • the active substances may be, for example, active substances selected from among the antibiotics and anti-infective agents, anticholinergics, antiglaucoma agents, antimycotics, antiseptics, anaesthetics, eye tonics, corticoids and steroids, film-forming agents, vaso-active substances, homoeopathic medicines, mydriatics, NSAID (antiphlogistics), prostaglandins, artificial tears, vitamins and/or virostatics.
  • active substances selected from among the antibiotics and anti-infective agents, anticholinergics, antiglaucoma agents, antimycotics, antiseptics, anaesthetics, eye tonics, corticoids and steroids, film-forming agents, vaso-active substances, homoeopathic medicines, mydriatics, NSAID (antiphlogistics), prostaglandins, artificial tears, vitamins and/or virostatics.
  • any pharmacologically and ophthalmologically acceptable pharmaceutical excipients may be added to the formulations.
  • these include inter alia arufil, benzalkonium chloride, boric acid, calcium chloride, carbomer, chlorhexidine digluconate, citric acid, EDTA, edetic acid salts; glucose, glutathione disulphide, hydroxyethylcellulose, hypromellose, potassium chloride, magnesium chloride, magnesium sulphate, magrocol, mannitol, sodium acetate, sodium chloride, sodium dihydrogen phosphate, sodium hydrogen carbonate, sodium hydroxide, sodium monohydrogen phosphate, sodium tetraborate, sodium thiosulphate, phenylmercury borate, polyethylene oxide, polyoxyethylene-polyoxypropylene copolymer, polysorbate, polyvinyl alcohol, povidone, hydrochloric acid, sorbitol, thiomersal and tyloxapol.
  • benzalkonium chloride is preferred over EDTA and the salts thereof.
  • ophthalmological formulations are applied uniformly to the surface of the eye, thereby improving absorption by the cornea or the conjunctiva;
  • the ophthalmological formulations can be more highly concentrated than conventional eye drops, so that the cornea or conjunctiva of the eye is or are subjected to smaller amounts of unpleasant-feeling foreign matter;
  • the amount delivered is comparatively small
  • each spray actuation is carried out consciously, so that the patient knows how many actuations have been done;
  • the aerosol particles have a low pulse and meet the surface of the eye with little force
  • the volume of a spray jet delivered with the atomizer described above, known by the trade mark Respimat® is e.g. 12 microlitres and the mass is therefore 0.000012 kg.
  • the speed of the cloud of droplets as a whole is 3.3 m/s and the pulse is roughly 0.0004 kg*m/s.
  • a force K of 0.033 milliNewtons is thus obtained, corresponding to a weight of about 3.3 mg.
  • an atomizer which delivers a mass of 0.0001 kg of 0.1 ml and has an average spray duration of 0.12 seconds would generate a cloud of particles with a force of 7.5 milliNewtons, corresponding to a weight of about 750 mg.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Devices For Medical Bathing And Washing (AREA)
US10/185,949 2001-06-29 2002-06-28 Atomizer for applying liquids onto eyes Abandoned US20030078551A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/185,949 US20030078551A1 (en) 2001-06-29 2002-06-28 Atomizer for applying liquids onto eyes
US10/601,737 US20040010239A1 (en) 2001-06-29 2003-06-23 Atomizer for applying liquids onto eyes
US11/457,506 US7314187B2 (en) 2001-06-29 2006-07-14 Atomizer for applying liquids onto eyes
US11/958,619 US20080097359A1 (en) 2001-06-29 2007-12-18 Atomizer for applying liquids onto eyes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10131178.8 2001-06-29
DE10131178A DE10131178A1 (de) 2001-06-29 2001-06-29 Vernebler zur Applikation von Flüssigkeiten in die Augen
US34878501P 2001-10-23 2001-10-23
US10/185,949 US20030078551A1 (en) 2001-06-29 2002-06-28 Atomizer for applying liquids onto eyes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/601,737 Continuation US20040010239A1 (en) 2001-06-29 2003-06-23 Atomizer for applying liquids onto eyes

Publications (1)

Publication Number Publication Date
US20030078551A1 true US20030078551A1 (en) 2003-04-24

Family

ID=7689762

Family Applications (4)

Application Number Title Priority Date Filing Date
US10/185,949 Abandoned US20030078551A1 (en) 2001-06-29 2002-06-28 Atomizer for applying liquids onto eyes
US10/601,737 Abandoned US20040010239A1 (en) 2001-06-29 2003-06-23 Atomizer for applying liquids onto eyes
US11/457,506 Expired - Lifetime US7314187B2 (en) 2001-06-29 2006-07-14 Atomizer for applying liquids onto eyes
US11/958,619 Abandoned US20080097359A1 (en) 2001-06-29 2007-12-18 Atomizer for applying liquids onto eyes

Family Applications After (3)

Application Number Title Priority Date Filing Date
US10/601,737 Abandoned US20040010239A1 (en) 2001-06-29 2003-06-23 Atomizer for applying liquids onto eyes
US11/457,506 Expired - Lifetime US7314187B2 (en) 2001-06-29 2006-07-14 Atomizer for applying liquids onto eyes
US11/958,619 Abandoned US20080097359A1 (en) 2001-06-29 2007-12-18 Atomizer for applying liquids onto eyes

Country Status (9)

Country Link
US (4) US20030078551A1 (fr)
EP (1) EP1408899A1 (fr)
JP (1) JP2004533304A (fr)
AR (1) AR034660A1 (fr)
CA (1) CA2451835A1 (fr)
DE (1) DE10131178A1 (fr)
MX (1) MXPA03011454A (fr)
PE (1) PE20030523A1 (fr)
WO (1) WO2003002045A1 (fr)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030217748A1 (en) * 2002-05-09 2003-11-27 Marc Giroux Particle dispersion chamber for nasal nebulizer
US20040149782A1 (en) * 2001-09-27 2004-08-05 Erhard Stohlmann Dropper, in particular eye dropper
US20040256487A1 (en) * 2003-05-20 2004-12-23 Collins James F. Ophthalmic drug delivery system
US20050247305A1 (en) * 2004-02-24 2005-11-10 Boehringer Ingelheim International Gmbh Nebulizer
US20070055214A1 (en) * 2005-08-10 2007-03-08 Gilbert Scott J Method for delivering drugs to tissue under microjet propulsion
US20070068514A1 (en) * 2001-09-28 2007-03-29 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US20070131230A1 (en) * 2003-09-05 2007-06-14 Kurve Technology, Inc. Nasal adapter for the base of the nose
US20070131224A1 (en) * 2003-09-05 2007-06-14 Kurve Technology, Inc. Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses
US20080054099A1 (en) * 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
US8012136B2 (en) * 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US8343117B1 (en) * 2010-01-19 2013-01-01 Michael Rosado Combination cigarette lighter and eye drop device
CN103585006A (zh) * 2013-11-21 2014-02-19 无锡伊佩克科技有限公司 一种眼药水瓶
US8684980B2 (en) 2010-07-15 2014-04-01 Corinthian Ophthalmic, Inc. Drop generating device
US8733935B2 (en) 2010-07-15 2014-05-27 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
WO2015148688A1 (fr) * 2014-03-26 2015-10-01 Nanomed Skincare, Inc. Dispositif de transport de masse de type piston pour l'administration par voie dermique et transdermique d'une composition liquide ou solide
CN106214480A (zh) * 2016-08-11 2016-12-14 重庆医科大学附属永川医院 一种医用雾化液储存瓶
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
CN109172960A (zh) * 2018-09-13 2019-01-11 苏州天健云康信息科技有限公司 一种液体药物输送装置及药物输送方法
US10639194B2 (en) 2011-12-12 2020-05-05 Eyenovia, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
CN112843449A (zh) * 2020-12-31 2021-05-28 贵州医科大学附属医院 一种雾化加压麻醉装置
US20210228822A1 (en) * 2018-05-04 2021-07-29 Boehringer Ingelheim International Gmbh Nebulizer and Container
US11464919B2 (en) * 2016-09-30 2022-10-11 Softhale Nv Atomiser, in particular inhaler, for atomising a liquid active agent to form an aerosol and a corresponding method
US11612704B2 (en) * 2017-04-28 2023-03-28 Softhale Nv Inhalation device and method
US11938056B2 (en) 2017-06-10 2024-03-26 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10131178A1 (de) * 2001-06-29 2003-01-16 Boehringer Ingelheim Pharma Vernebler zur Applikation von Flüssigkeiten in die Augen
DE102004001451A1 (de) 2004-01-08 2005-08-11 Boehringer Ingelheim International Gmbh Vorrichtung zum Haltern eines fluidischen Bauteiles
JP2007522902A (ja) * 2004-02-24 2007-08-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
DE102004048503A1 (de) * 2004-10-05 2006-04-13 Thilo Schleip Vorrichtung zur Benetzung von Kontaktlinsen im Auge
WO2006117640A1 (fr) * 2005-04-29 2006-11-09 Pfizer Inc. Appareil et procede d'administration de solutions ophtalmiques
DE102006025871A1 (de) * 2006-06-02 2007-12-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber
CN101093771A (zh) * 2006-06-23 2007-12-26 清华大学 碳纳米管场发射体及其制造方法
US8034036B2 (en) * 2007-04-10 2011-10-11 Tom Osborne Portable eye flushing system and method
DE102007023012A1 (de) * 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber und Filter
EP2077132A1 (fr) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
US20090192443A1 (en) * 2008-10-06 2009-07-30 Collins Jr James F Ophthalmic fluid delivery device and method of operation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
EP2432531B1 (fr) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adaptateur, dispositif d'inhalation et pulvérisateur
EP2504051B1 (fr) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nébuliseur
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064164A1 (fr) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nébuliseur
EP2347749A1 (fr) * 2010-01-22 2011-07-27 Innovaider ApS Appareil portable pour le lavage des yeux
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
DE102010048085A1 (de) * 2010-10-04 2012-04-05 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
EP2447694B1 (fr) 2010-10-28 2014-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Fuite d'essai pour le contrôle de systèmes de mesure de fuites
EP2694220B1 (fr) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Appareil médical pourvu d'un récipient
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
FR2976000B1 (fr) 2011-05-31 2014-12-26 Arkema France Procede pour augmenter la recyclabilite d'un polyamide utilise en frittage
US9004063B1 (en) * 2011-08-17 2015-04-14 Shane M. Guldbransen Portable oxygen inhaler device
WO2013152894A1 (fr) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Pulvérisateur comprenant des moyens de détrompage
EP3030298B1 (fr) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nébuliseur
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
EP3099362B1 (fr) 2014-01-31 2018-09-12 Eye-go A/S Dispositif d'application de produit ophtalmologique
CA2948071C (fr) 2014-05-07 2022-08-30 Boehringer Ingelheim International Gmbh Contenant, nebuliseur et utilisation
HUE055604T2 (hu) 2014-05-07 2021-12-28 Boehringer Ingelheim Int Porlasztó
AU2015258110B2 (en) 2014-05-07 2019-06-20 Boehringer Ingelheim International Gmbh Nebulizer, indicator device and container
ES2907828T3 (es) 2015-06-03 2022-04-26 Novopyxis Inc Método para general una nebulización en aerosol
US10893977B2 (en) * 2017-01-17 2021-01-19 Omera Medical, Inc. Device and method to treat eye conditions, eyelids conditions, or both
CN112753607B (zh) * 2021-01-28 2022-06-03 塔里木大学 一种家禽疾病防控养殖笼

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2920624A (en) * 1958-07-31 1960-01-12 Gillette Co Eye drop dispenser
US5037406A (en) * 1988-06-20 1991-08-06 Smith William L Eyedrop applicator attachment
CA1325568C (fr) * 1988-06-24 1993-12-28 Pineway (Uk) Ltd. Dispositif pour bain oculaire
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
DE4409845C2 (de) * 1994-02-17 1995-08-31 Immanuel Chi Tragbare Vorrichtung zum Besprühen von Augen
WO1996000050A1 (fr) 1994-06-23 1996-01-04 R.P. Scherer Corporation Dispositif de traitement oculaire
DE9412662U1 (de) 1994-08-05 1994-10-06 Ing. Erich Pfeiffer Gmbh & Co Kg, 78315 Radolfzell Austragvorrichtung für Medien
US5588564A (en) 1995-08-21 1996-12-31 Hutson; Clifford L. Eye spray mist dispenser
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
US5578021A (en) * 1995-10-05 1996-11-26 Cornish; Brian K. Eye medicament dispensing device
DE19742439C1 (de) 1997-09-26 1998-10-22 Boehringer Ingelheim Int Mikrostrukturiertes Filter
GB9722145D0 (en) 1997-10-21 1997-12-17 Mentholatum The Company Spray device
DE10131178A1 (de) * 2001-06-29 2003-01-16 Boehringer Ingelheim Pharma Vernebler zur Applikation von Flüssigkeiten in die Augen

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040149782A1 (en) * 2001-09-27 2004-08-05 Erhard Stohlmann Dropper, in particular eye dropper
US20070068514A1 (en) * 2001-09-28 2007-03-29 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US8448637B2 (en) 2001-09-28 2013-05-28 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US9572943B2 (en) 2001-09-28 2017-02-21 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US7866316B2 (en) 2001-09-28 2011-01-11 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US20030217748A1 (en) * 2002-05-09 2003-11-27 Marc Giroux Particle dispersion chamber for nasal nebulizer
US10668230B2 (en) 2002-05-09 2020-06-02 Kurve Technology, Inc. Particle dispersion chamber for nasal nebulizer
US9352106B2 (en) 2002-05-09 2016-05-31 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US20090159080A1 (en) * 2002-05-09 2009-06-25 Kurve Technology, Inc. Particle dispersion chamber for nasal nebulizer
US8122881B2 (en) 2002-05-09 2012-02-28 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US8012136B2 (en) * 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
US20040256487A1 (en) * 2003-05-20 2004-12-23 Collins James F. Ophthalmic drug delivery system
US8936021B2 (en) 2003-05-20 2015-01-20 Optimyst Systems, Inc. Ophthalmic fluid delivery system
US7883031B2 (en) 2003-05-20 2011-02-08 James F. Collins, Jr. Ophthalmic drug delivery system
US20070131224A1 (en) * 2003-09-05 2007-06-14 Kurve Technology, Inc. Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses
US20070131230A1 (en) * 2003-09-05 2007-06-14 Kurve Technology, Inc. Nasal adapter for the base of the nose
US8001963B2 (en) 2003-09-05 2011-08-23 Kurve Technology, Inc. Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses
US20110048415A1 (en) * 2004-02-24 2011-03-03 Boehringer Ingelheim International Gmbh Nebulizer
US7849851B2 (en) 2004-02-24 2010-12-14 Boehringer Ingelheim International Gmbh Nebulizer
US20050247305A1 (en) * 2004-02-24 2005-11-10 Boehringer Ingelheim International Gmbh Nebulizer
US8997735B2 (en) 2004-02-24 2015-04-07 Boehringer Ingelheim International Gmbh Nebulizer
US20070055214A1 (en) * 2005-08-10 2007-03-08 Gilbert Scott J Method for delivering drugs to tissue under microjet propulsion
US8591457B2 (en) 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
US20070052139A1 (en) * 2005-08-10 2007-03-08 Gilbert Scott J Method for making a needle-free jet injection drug delivery device
US8998881B2 (en) * 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
US20080054099A1 (en) * 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
US8733342B2 (en) 2006-08-30 2014-05-27 Kurve Technology, Inc. Aerosol generating and delivery device
US10105501B2 (en) 2006-08-30 2018-10-23 Kurve Technology, Inc. Aerosol generating and delivery device
US7905229B2 (en) 2006-08-30 2011-03-15 Kurve Technology, Inc. Aerosol generating and delivery device
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
US8343117B1 (en) * 2010-01-19 2013-01-01 Michael Rosado Combination cigarette lighter and eye drop device
US8684980B2 (en) 2010-07-15 2014-04-01 Corinthian Ophthalmic, Inc. Drop generating device
US10839960B2 (en) 2010-07-15 2020-11-17 Eyenovia, Inc. Ophthalmic drug delivery
US11839487B2 (en) 2010-07-15 2023-12-12 Eyenovia, Inc. Ophthalmic drug delivery
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
US10073949B2 (en) 2010-07-15 2018-09-11 Eyenovia, Inc. Ophthalmic drug delivery
US8733935B2 (en) 2010-07-15 2014-05-27 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US11398306B2 (en) 2010-07-15 2022-07-26 Eyenovia, Inc. Ophthalmic drug delivery
US11011270B2 (en) 2010-07-15 2021-05-18 Eyenovia, Inc. Drop generating device
US10646373B2 (en) 2011-12-12 2020-05-12 Eyenovia, Inc. Ejector mechanism, ejector device, and methods of use
US10639194B2 (en) 2011-12-12 2020-05-05 Eyenovia, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
CN103585006A (zh) * 2013-11-21 2014-02-19 无锡伊佩克科技有限公司 一种眼药水瓶
WO2015148688A1 (fr) * 2014-03-26 2015-10-01 Nanomed Skincare, Inc. Dispositif de transport de masse de type piston pour l'administration par voie dermique et transdermique d'une composition liquide ou solide
CN106214480A (zh) * 2016-08-11 2016-12-14 重庆医科大学附属永川医院 一种医用雾化液储存瓶
US11464919B2 (en) * 2016-09-30 2022-10-11 Softhale Nv Atomiser, in particular inhaler, for atomising a liquid active agent to form an aerosol and a corresponding method
US11612704B2 (en) * 2017-04-28 2023-03-28 Softhale Nv Inhalation device and method
US11938056B2 (en) 2017-06-10 2024-03-26 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
US20210228822A1 (en) * 2018-05-04 2021-07-29 Boehringer Ingelheim International Gmbh Nebulizer and Container
US12036355B2 (en) * 2018-05-04 2024-07-16 Boehringer Ingelheim International Gmbh Nebulizer and container
CN109172960A (zh) * 2018-09-13 2019-01-11 苏州天健云康信息科技有限公司 一种液体药物输送装置及药物输送方法
CN112843449A (zh) * 2020-12-31 2021-05-28 贵州医科大学附属医院 一种雾化加压麻醉装置

Also Published As

Publication number Publication date
US7314187B2 (en) 2008-01-01
AR034660A1 (es) 2004-03-03
EP1408899A1 (fr) 2004-04-21
JP2004533304A (ja) 2004-11-04
MXPA03011454A (es) 2004-04-05
US20040010239A1 (en) 2004-01-15
PE20030523A1 (es) 2003-07-01
US20080097359A1 (en) 2008-04-24
CA2451835A1 (fr) 2003-01-09
WO2003002045A1 (fr) 2003-01-09
DE10131178A1 (de) 2003-01-16
US20060258993A1 (en) 2006-11-16

Similar Documents

Publication Publication Date Title
US7314187B2 (en) Atomizer for applying liquids onto eyes
US20040164099A1 (en) Nebulizer for applying liquids on the surface of the eye or the ocular connective tissue
US20090182291A1 (en) Eye medicament dispenser
US20120179122A1 (en) Device for applying an ophthalmic medicament mist
US7977045B2 (en) Aqueous-based pharmaceutical composition
US7284713B2 (en) System comprising a nozzle and a fixing means therefor
WO1998012511A2 (fr) Distributeur de fluide
JP2002502289A (ja) 眼流体用アプリケーター
US8133210B2 (en) Aqueous ophthalmic spray and method for delivery of artificial tears to the ocular surface
CA2606469A1 (fr) Appareil et procede d'administration de solutions ophtalmiques
JP2000093483A (ja) 洗浄用スパウト装置
ITMI951196A1 (it) Dispositivo per l'erogazione oculare di liquidi nebulizzati

Legal Events

Date Code Title Description
AS Assignment

Owner name: BOEHRINGER INGELHEIM PHARMA KG, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HOCHRAINER, DIETER;ZIERENBERG, BERND;DIESTELHORST, MICHAEL;AND OTHERS;REEL/FRAME:013239/0938;SIGNING DATES FROM 20020729 TO 20020814

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION