US10595976B2 - Oral care device - Google Patents

Oral care device Download PDF

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Publication number
US10595976B2
US10595976B2 US15/572,942 US201615572942A US10595976B2 US 10595976 B2 US10595976 B2 US 10595976B2 US 201615572942 A US201615572942 A US 201615572942A US 10595976 B2 US10595976 B2 US 10595976B2
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weight
delivery system
layer
water soluble
inclusive
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US20180125626A1 (en
Inventor
Brian Joseph Groves
Adam John Limer
William John Wilson
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Conopco Inc
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Conopco Inc
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Assigned to CONOPCO INC., D/B/A UNILEVER reassignment CONOPCO INC., D/B/A UNILEVER ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GROVES, BRIAN JOSEPH, LIMER, ADAM JOHN, WILSON, WILLIAM JOHN
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/0233—Distinct layers, e.g. core/shell sticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to an oral care products for the remineralisation and whitening of teeth.
  • Teeth are important both functionally and aesthetically. There is a need for strong healthy teeth that appear white and glossy.
  • Calcium phosphate is the primary component of the enamel and dentin in the form of hydroxyapatite.
  • hydroxyapatite In the mouth, there is a natural equilibrium between hydroxyapatite being dissolved from the enamel of teeth and hydroxyapatite being formed on or in the teeth from substances occurring naturally in the saliva. This equilibrium is shifting continuously, but diet and physical conditions can result in hydroxyapatite being dissolved arising in demineralisation.
  • Remineralisation hardens and strengthens the teeth, thereby providing protection from and treatment for dental erosion and/or tooth wear. It also reduces the likelihood of tooth decay and improves the appearance of the teeth, in particular their whiteness. The teeth may also appear smoother and shinier as a result.
  • U.S. Pat. No. 5,605,675 discloses a process for remineralisation of dental enamel by application of a two-phase composition; one phase containing a water-soluble calcium compound and one phase containing a water soluble inorganic phosphate and a water-soluble fluorine compound.
  • U.S. Pat. No. 4,083,955 discloses a process for remineralisation of dental enamel by sequential application of two compositions, the first comprising calcium ions and second comprising phosphate ions, or vice versa.
  • the present invention relates to a delivery system for delivering a enamel regeneration system to the surfaces of teeth
  • the delivery system comprising a delivery device and a separate activator composition
  • the delivery device comprising; a strip of an orally acceptable flexible material, having a strip surface capable of being applied to a tooth surface, the strip having components of an enamel regeneration system deposited upon the strip surface thereof, and/or impregnated into its structure and the activator system comprising water.
  • the delivery device of the invention comprises a strip of an orally acceptable flexible material.
  • the surface of the strip is capable of being applied to a tooth surface.
  • the device has an elongate shape of a length sufficient that when placed against the front surface of a user's teeth it extends across a plurality of teeth, and of sufficient width that it extends at least from the gumline of the teeth to the crowns of the teeth.
  • the elongate shape is such that it minimises the need for subsequent applications and time to cover all the user's teeth.
  • the strip is such that it can be sufficient that when placed against the front surface of a user's teeth it extends across a plurality of teeth, and of sufficient width that it extends at least from the front gumline of the teeth to the crowns of the teeth and to the gumline behind the user's teeth leading to total coverage of the teeth above the gumline.
  • the application device is rectangular in shape.
  • the strip/device has the enamel regeneration system deposited upon the strip surface thereof as a layer or more preferably multiple layers.
  • the device is a strip comprising a plurality of layers.
  • the device comprises at least two layers; one layer comprises a non-dissolving backing film, a second layer comprises a component of the enamel regeneration system. More preferably the strip comprises third protective layer it is particularly preferred if the third protective layer comprises a water soluble polymer.
  • the non-dissolving backing layer comprises materials such as polymers, natural and synthetic wovens, non-wovens, foil, paper, rubber, and combinations thereof.
  • the strip of material may be a single layer of material or a laminate of more than one layer. Generally, the strip of material is substantially water impermeable.
  • the material may be any type of polymer that is compatible with tooth whitening actives and is sufficiently flexible to be shaped and applied to the tooth surface.
  • the material may comprise a single polymer or a mixtures of polymers. Suitable polymers include, but are not limited to, polyethylene, polypropylene, ethylvinylacetate, ethylvinyl alcohol, polyesters, polyamides, fluoroplastics and combinations thereof.
  • the material is polyethylene.
  • the strip of material is generally less than about 1 mm thick, preferably less than about 0.05 mm thick, and more preferably from about 0.001 to about 0.03 mm thick.
  • the strip has a second layer comprising components of the enamel regeneration system. It is advantageous if the component of the enamel regeneration system is a water insoluble and/or slightly soluble calcium source.
  • Soluble and insoluble calcium source refers to the solubility of the calcium source in water.
  • Soluble means a source that dissolves in water to give a solution with a concentration of at least 0.1 moles per liter at room temperature.
  • Insoluble means a source that dissolves in water to give a solution with a concentration of less than 0.001 moles per liter at room temperature.
  • Slightly soluble therefore, is defined to mean a source that dissolves in water to give a solution with a concentration of greater than 0.001 moles per liter at room temperature and less than 0.1 moles per liter at room temperature.
  • Substantially free of, as used herein, means less than 1.5%, and preferably, less than 1.0%, and most preferably, from 0.0 to 0.75% by weight, based on total weight of the oral care composition, including all ranges subsumed therein.
  • the calcium source suitable for use in this invention is limited only to the extent that the same may be used in an oral cavity.
  • the calcium source employed is insoluble or slightly soluble in water, but most preferably, insoluble in water.
  • Illustrative examples of the types of calcium source that may be used in this invention include, for example, calcium phosphate (i.e., added), calcium gluconate, calcium oxide, calcium lactate, calcium carbonate, calcium hydroxide, calcium sulfate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate, mixtures thereof or the like.
  • the calcium source is calcium silicate.
  • the calcium silicate used is (CaS i O 3 ) whereby the same is made commercially available under the name Microcal ET by Ineos Silicas, Ltd.
  • the calcium source is insoluble calcium silicate, present as the composite material calcium oxide-silica (CaO—SiO 2 ) as described in commonly-owned application Publication No. 2008/015117.
  • the ratio of calcium to silicon may be from 1:10 to 3:1.
  • the Ca:Si ratio is preferably from 1:5 to 2:1, and more preferably, from 1:3 to 2:1, and most preferably, from about 1:2 to 2:1.
  • the calcium silicate may comprise mono-calcium silicate, bi-calcium silicate, or tri-calcium silicate whereby ratios of calcium to silicon (Ca:Si) should be understood to be atom ratios.
  • the calcium source employed in this invention may be in a crystalline or amorphous state, and preferably, the same is in an amorphous state.
  • the calcium source is in a mesoporous state, i.e. the source is a material having pores with diameters from 1 nm to 50 microns.
  • Mesoporous calcium silicate (MCS) is often preferred.
  • the MCS which may be used in this invention can be made by combining a calcium salt, a silica precursor like silicate and a structure-directing agent to yield a solid suitable for calcinating.
  • a structure-directing agent to yield a solid suitable for calcinating.
  • the amount of calcium source in the composition present as the second layer of this invention is typically from 0.1 to 50%, and preferably, from 1 to 30%, and most preferably, from 5 to 20% by weight of the oral care composition based on total weight of the oral care composition and including all ranges subsumed therein.
  • the second layer is non-aqueous, that is that the composition comprises less than 1 wt % of the total composition of the second layer of water, preferably less than 0.5 wt % of water.
  • the second layer is sandwiched between the first backing layer and a third layer.
  • the device comprises a third layer.
  • the third layer preferably comprises a water soluble polymer or polymers.
  • Suitable water soluble polymers may be natural or synthetic.
  • Suitable natural hydrocolloids and water soluble polymers include cellulosic material, a polysaccharide, a gum, a protein, a starch or a glucan.
  • Examples include but are not limited to carboxymethyl cellulose, hydroxyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, gum Arabic, xanthan gum, karaya gum, tragacanth, acacia, carrageenan, guar gum, locust bean gum, pectin, alginates, polydextrose, dextrin, dextran, amylose, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and pullan.
  • Suitable water soluble synthetic polymers include but are not limited to poly(vinyl pyrrolidone), poly(vinyl alcohol), poly(acrylic acid), polyacrylates, Methylmethacrylate copolymer, carboxyvinyl polymer, polyethylene oxide and polyethylene glycol.
  • the water soluble polymer layer is preferably a mixture of methylcellulose and hydroxypropyl methylcellulose.
  • the advantage of having a water soluble layer and a non-water soluble layer is that in the mouth the water soluble layer dissolves in the saliva and the ingredients enclosed therein (the phosphate) can react with the ingredients in the second layer (silicate) to aid the in-situ regeneration of enamel on the teeth.
  • the system provides an enamel regeneration system that can be used with the minimum of water, can be easily stored and is stable on storage.
  • the composition of the invention comprises titanium dioxide.
  • the titanium dioxide is present in the second layer of the device.
  • a preferred form of titanium dioxide is calcium silicate coated TiO 2 . Examples of preferred forms of calcium silicate coated TO02 are disclosed in WO2012/031786 and WO2012/031785.
  • the thickness of the first layer is less than about 1 mm thick, preferably less than about 0.05 mm thick, and more preferably from about 0.001 to about 0.03 mm thick
  • second layer is less than about 1 mm thick, preferably less than about 0.5 mm thick, and more preferably from about 0.001 to about 0.3 mm thick
  • third layer is less than about 1 mm thick, preferably less than about 0.5 mm thick, and more preferably from about 0.001 to about 0.3 mm thick.
  • the activator serum comprises an aqueous base formulation.
  • the activator serum preferably comprises a phosphate source.
  • the phosphate source that may be used in this invention is limited only to the extent that the same may be used in a composition suitable for use in an oral cavity.
  • Illustrative examples of the types of phosphate source suitable for use in this invention include monosodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, potassium dihydrogenphosphate, trisodium phosphate, tripotassium phosphate, mixtures thereof or the like.
  • the phosphate source is preferably one which is water soluble.
  • the phosphate source makes up from 0.5 to 15%, and preferably, from 2 to 12%, and most preferably, from 4 to 9% by weight of the composition used in the third layer, based on total weight of the composition of the third layer and including all ranges subsumed therein.
  • the phosphate source used is one which results in an oral care composition having a pH from 5.5 to 8, preferably from 6 to 7.5, and most preferably, about neutral.
  • the phosphate source used is trisodium phosphate and monosodium dihydrogen phosphate at a trisodium phosphate to monosodium dihydrogen phosphate weight ratio of 1:4 to 4:1, preferably 1:3 to 3:1, and most preferably, from 1:2 to 2:1, including all ratios subsumed therein.
  • the composition of the activator comprises an aqueous base, that is that that the composition comprises greater than 50 wt % of the serum composition of water, more preferably greater than 70 wt %.
  • the oral care composition described herein may comprise ingredients which are common in the art, such as:
  • Such ingredients common in the art typically and collectively make-up less than 20% by weight of the oral care composition, and preferably, from 0.0 to 15% by weight, and most preferably, from about 0.01 to about 12% by weight of the oral care composition, including all ranges subsumed therein.
  • Suitable carrier humectants are preferably used in the oral care composition of the present invention and they include, for example, glycerin, sorbitol, propylene glycol, dipropylene glycol, diglycerol, triacetin, mineral oil, polyethylene glycol (preferably, PEG-400), alkane diols like butane diol and hexanediol, ethanol, pentylene glycol, or a mixture thereof.
  • the carrier humectants should, in any case, be substantially free of water, and preferably, anhydrous. The same, for example, can be used in solid form, whereby glycerin is the preferred carrier humectant.
  • Such carriers are particularly suitable in compositions used in the second layer.
  • the carrier humectant is used to take the balance of the compositions up to 100%, and the same may be present in the range of from 10 to 90% by weight of the oral care composition.
  • the carrier humectant makes up from 25 to 80%, and most preferably, from 45 to 70% by weight of the oral care composition, based on total weight of the oral care composition and including all ranges subsumed therein.
  • composition used in the layers of the invention are prepared by conventional methods of making oral care formulations. Such methods include mixing the ingredients under moderate shear and atmospheric pressure.
  • the invention provides a method of whitening and remineralising teeth.
  • the activator serum is applied to the strips of the invention.
  • the activated strips as described above are applied to the surface of the teeth in sustained contact.
  • sustained contact means the product is left on the teeth for 1 to 60 minutes, preferably, about 5 to 45 minutes, more preferably 10 to 30 minutes before being removed.
  • the application of the oral care product of the invention is carried out once daily for a period of several consecutive days, in addition to a regular regime of tooth brushing (preferably at least twice daily).
  • a new hydroxyapatite layer on teeth that is from 0.5 to 20 microns, and preferably, from 0.75 to 5 microns, including all ranges subsumed therein.
  • FIG. 1 is a cross sectional view of the strip.
  • a device ( 1 ) of the invention is shown in section.
  • the device comprises a strip 2 of insoluble backing material, this can be considered the bottom layer
  • Coated onto the insoluble backing material ( 2 ) is a second layer ( 3 ) comprising calcium silicate and titanium dioxide composite, a third protective layer ( 4 ) is present as the top layer in contact with the second layer.
  • a simulated oral fluid was prepared by adding 1.9 L of water to a glass beaker. The following materials were added one by one with continuous stirring, allowing sufficient time for each chemical to fully dissolve before adding the next.
  • the pH was adjusted to 7.0 using saturated TRIS buffer and the total volume made up to 2 L using a volumetric flask.
  • the water and glycerol was weighed into a beaker.
  • the polymers added slowly while under shear using a Silverson LR4 bench top mixer and mixed until the polymer is fully dispersed (no lumps visible).
  • NB Air can become entrapped in the solution if required this can be removed using a desiccator.
  • the film can be removed from the tile and cut to the appropriate size.
  • the glycerol and Xanthan were added to the Esco-Labor 1 L mixing vessel and stirring at 65° C. for 30 minutes to disperse the xanthan gum. Once the Xanthan has been fully dispersed the remaining powders are added slowly and mixed to remove any lumps.
  • the multilayer film was produced as follows.
  • Stage 1 a piece of plastic film (polyethylene) was cut to the appropriate size.
  • Stage 3 using a small paint brush the conc slurry was painted on to one side of the film (wt of material 0.136 g) and then placed on top of the plastic film.
US15/572,942 2015-06-05 2016-05-05 Oral care device Active US10595976B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15170828 2015-06-05
EP15170828.6 2015-06-05
EP15170828 2015-06-05
PCT/EP2016/060125 WO2016192924A1 (en) 2015-06-05 2016-05-05 Oral care device

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US20180125626A1 US20180125626A1 (en) 2018-05-10
US10595976B2 true US10595976B2 (en) 2020-03-24

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US (1) US10595976B2 (ru)
EP (1) EP3302349B1 (ru)
CN (1) CN107743386A (ru)
BR (1) BR112017023494B1 (ru)
CL (1) CL2017003086A1 (ru)
EA (1) EA035371B1 (ru)
PH (1) PH12017502038B1 (ru)
WO (1) WO2016192924A1 (ru)

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EP3888619A1 (en) 2020-04-02 2021-10-06 Unilever Global IP Ltd Oral care device
EP3888622A1 (en) * 2020-04-02 2021-10-06 Unilever Global IP Ltd Oral care system
EP3888621A1 (en) 2020-04-02 2021-10-06 Unilever Global IP Ltd Oral care device

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