UA97787C2 - Защита доминантным негативным мутантным krp-белком ингибирования активного циклин-cdk-комплекса krp-белком дикого типа - Google Patents

Защита доминантным негативным мутантным krp-белком ингибирования активного циклин-cdk-комплекса krp-белком дикого типа

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Publication number
UA97787C2
UA97787C2 UAA200802670A UAA200802670A UA97787C2 UA 97787 C2 UA97787 C2 UA 97787C2 UA A200802670 A UAA200802670 A UA A200802670A UA A200802670 A UAA200802670 A UA A200802670A UA 97787 C2 UA97787 C2 UA 97787C2
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Ukraine
Prior art keywords
protein
cyclin
wild type
cdk
krp
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UAA200802670A
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English (en)
Ukrainian (uk)
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Пол Оливиер
Джей Дерошер
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Таргитед Гроут, Инк.
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Application filed by Таргитед Гроут, Инк. filed Critical Таргитед Гроут, Инк.
Publication of UA97787C2 publication Critical patent/UA97787C2/ru

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Изобретение относится к изолированным мутантным полипептодам-ингибиторам растительных циклин-зависимых киназ (CKI), содержащих аминокислотную последовательность CKI, имеющую как минимум одну модификацию относительно растительного CKI- полипептида дикого типа, причем указанный CKI-полипептид дикого типа сдержит участок связывания с циклином, который придает афинность связывания с циклином и участок связывания с циклин-зависимой киназой (CDK), который придает афинность связывания с CDK, причем указанная как минимум одна модификация находится в пределах участка связывания CDK, а мутантный CKI-полипептид может конкурировать с указанным CKI дикого типа за связывание с комплексом циклин/CDK и не ингибирует активности киназы CDK. Указанные мутантные белки используются для модулирования цитокинеза в клетках и, в частности, в растите�
UAA200802670A 2005-07-29 2006-07-28 Защита доминантным негативным мутантным krp-белком ингибирования активного циклин-cdk-комплекса krp-белком дикого типа UA97787C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70399905P 2005-07-29 2005-07-29
PCT/US2006/029349 WO2007016319A2 (en) 2005-07-29 2006-07-28 Dominant negative mutant krp protein protection of active cyclin-cdk complex inhibition by wild-type krp

Publications (1)

Publication Number Publication Date
UA97787C2 true UA97787C2 (ru) 2012-03-26

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Application Number Title Priority Date Filing Date
UAA200802670A UA97787C2 (ru) 2005-07-29 2006-07-28 Защита доминантным негативным мутантным krp-белком ингибирования активного циклин-cdk-комплекса krp-белком дикого типа

Country Status (15)

Country Link
US (3) US8742205B2 (ru)
EP (2) EP1924136A4 (ru)
JP (1) JP2009502175A (ru)
KR (1) KR20080052570A (ru)
CN (1) CN101296613B (ru)
AR (1) AR054599A1 (ru)
AU (1) AU2006275753B2 (ru)
BR (1) BRPI0614695A2 (ru)
CA (1) CA2619383C (ru)
ES (1) ES2502415T3 (ru)
IL (1) IL189051A0 (ru)
RU (1) RU2421462C2 (ru)
UA (1) UA97787C2 (ru)
WO (1) WO2007016319A2 (ru)
ZA (1) ZA200801892B (ru)

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Also Published As

Publication number Publication date
ES2502415T3 (es) 2014-10-03
CN101296613A (zh) 2008-10-29
US20070056058A1 (en) 2007-03-08
US9637754B2 (en) 2017-05-02
AU2006275753A1 (en) 2007-02-08
AU2006275753B2 (en) 2012-01-12
WO2007016319A3 (en) 2007-06-14
US8742205B2 (en) 2014-06-03
EP1924136A2 (en) 2008-05-28
BRPI0614695A2 (pt) 2011-04-12
US20170275640A1 (en) 2017-09-28
CA2619383A1 (en) 2007-02-08
RU2008107302A (ru) 2009-09-10
AR054599A1 (es) 2007-06-27
IL189051A0 (en) 2008-08-07
EP1924136A4 (en) 2009-05-13
CN101296613B (zh) 2016-02-10
RU2421462C2 (ru) 2011-06-20
US20140331362A1 (en) 2014-11-06
EP2422615B1 (en) 2014-06-18
JP2009502175A (ja) 2009-01-29
WO2007016319A2 (en) 2007-02-08
CA2619383C (en) 2014-09-16
ZA200801892B (en) 2009-08-26
KR20080052570A (ko) 2008-06-11
EP2422615A3 (en) 2012-04-18
EP2422615A2 (en) 2012-02-29

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