UA89684C2 - Двухслойная фармацевтическая дозированная форма с модифицированным высвобождением нимесулида - Google Patents

Двухслойная фармацевтическая дозированная форма с модифицированным высвобождением нимесулида

Info

Publication number
UA89684C2
UA89684C2 UAA200802135A UAA200802135A UA89684C2 UA 89684 C2 UA89684 C2 UA 89684C2 UA A200802135 A UAA200802135 A UA A200802135A UA A200802135 A UAA200802135 A UA A200802135A UA 89684 C2 UA89684 C2 UA 89684C2
Authority
UA
Ukraine
Prior art keywords
dosage form
enzyme inhibitor
cyclooxygenase enzyme
accordance
employing
Prior art date
Application number
UAA200802135A
Other languages
English (en)
Ukrainian (uk)
Inventor
Раджеш Джайн
Коур Чанд Джиндал
Сукхджит Сингх
Муниш Талвар
Original Assignee
Панасеа Биотек Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Панасеа Биотек Лтд. filed Critical Панасеа Биотек Лтд.
Publication of UA89684C2 publication Critical patent/UA89684C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Изобретение касается двухслойной фармацевтической дозированной формы с модифицированным высвобождением, которая включает нимесулид или его фармацевтически приемлемые соли, эфиры, сольваты или гидраты в качестве активного ингредиента, который распределен между слоем немедленного высвобождения и слоем длительного высвобождения в соотношении 1:3, соответственно, в которой нимесулид обработан, по крайней мере, одним контролирующим высвобождение полимером, таким как гидроксипропилметилцеллюлоза, где контролирующий высвобождение полимер присутствует в количестве от примерно 10% масс./масс. до не более, чем приблизительно 30% масс./масс. двухслойной композиции.
UAA200802135A 2005-07-20 2006-07-19 Двухслойная фармацевтическая дозированная форма с модифицированным высвобождением нимесулида UA89684C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1899DE2005 2005-07-20

Publications (1)

Publication Number Publication Date
UA89684C2 true UA89684C2 (ru) 2010-02-25

Family

ID=37669241

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200802135A UA89684C2 (ru) 2005-07-20 2006-07-19 Двухслойная фармацевтическая дозированная форма с модифицированным высвобождением нимесулида

Country Status (20)

Country Link
US (1) US20100204333A1 (ru)
EP (1) EP1906933A2 (ru)
JP (1) JP2009501785A (ru)
KR (1) KR20080032209A (ru)
CN (1) CN101227893A (ru)
AR (1) AR055090A1 (ru)
AU (1) AU2006271150A1 (ru)
BR (1) BRPI0613547A2 (ru)
CA (1) CA2614850A1 (ru)
CR (1) CR9828A (ru)
DE (1) DE202006020331U1 (ru)
DK (1) DK200900115U1 (ru)
EA (1) EA200800370A1 (ru)
MX (1) MX2008000967A (ru)
NO (1) NO20080697L (ru)
RS (1) RS20080020A (ru)
TN (1) TNSN08018A1 (ru)
UA (1) UA89684C2 (ru)
WO (1) WO2007010559A2 (ru)
ZA (1) ZA200801592B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090007608A (ko) * 2006-04-24 2009-01-19 파나세아 바이오테크 리미티드 니메술리드를 포함하는 새로운 형태의 저복용 약학조성물 및 이의 조제 및 사용방법
BRPI0717769A2 (pt) 2006-10-17 2013-11-05 Nuvo Res Formulação de gel, método para o tratamento da osteoartrite em um indivíduo sofrendo de dor articular, e, uso de diclofenac de sódio
US8546450B1 (en) * 2009-03-31 2013-10-01 Nuvo Research Inc. Treatment of pain with topical diclofenac compounds
US8618164B2 (en) 2009-03-31 2013-12-31 Nuvo Research Inc. Treatment of pain with topical diclofenac compounds
WO2010146187A2 (en) 2009-06-19 2010-12-23 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of telmisartan
CN102188386B (zh) * 2010-03-02 2013-09-04 海南葫芦娃制药有限公司 尼美舒利缓释微丸及其制备方法
US8951996B2 (en) * 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
RU2603471C2 (ru) * 2012-01-04 2016-11-27 УЭЛЛСЛИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Состав с замедленным высвобождением для снижения частоты мочеиспускания и способ его применения
US8987282B2 (en) 2012-02-06 2015-03-24 Innovative Med Concepts, LLC Acyclovir and meloxicam combination therapy for functional somatic syndromes
US9018246B2 (en) 2012-09-05 2015-04-28 Lp Pharmaceutical (Xiamen) Co., Ltd. Transmucosal administration of taxanes
HUP1500618A2 (en) 2015-12-16 2017-06-28 Druggability Tech Ip Holdco Ltd Complexes of celecoxib and its salts and derivatives, process for the preparation thereof and pharmaceutical composition containing them
US10350171B2 (en) 2017-07-06 2019-07-16 Dexcel Ltd. Celecoxib and amlodipine formulation and method of making the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66933B1 (en) * 1990-01-15 1996-02-07 Elan Corp Plc Controlled absorption naproxen formulation for once-daily administration
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
ES2129010B1 (es) * 1997-01-02 2000-01-16 Gold Oscar Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.
WO1999012524A1 (en) * 1997-09-11 1999-03-18 Nycomed Danmark A/S MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs)
IN188720B (ru) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
AU718356B2 (en) * 1998-01-12 2000-04-13 Panacea Biotec Limited A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
AU5134699A (en) * 1998-07-24 2000-02-14 Andrix Pharmaceuticals, Inc. Granule modulating hydrogel system
US6086920A (en) 1998-08-12 2000-07-11 Fuisz Technologies Ltd. Disintegratable microspheres
JP5026635B2 (ja) 1998-09-10 2012-09-12 ニュコメデ ダンマルク アンパーツセルスカブ 医薬物質の迅速放出医薬組成物
AU774099B2 (en) * 1999-09-28 2004-06-17 Panacea Biotec Limited Controlled release compositions comprising nimesulide
IN190018B (ru) * 1999-09-28 2003-05-31 Panacea Biotec Ltd
JP2003518061A (ja) 1999-12-22 2003-06-03 ファルマシア コーポレイション シクロオキシゲナーゼ−２阻害剤の持続放出製剤
EP1272181A2 (en) 2000-04-13 2003-01-08 Synthon B.V. Modified release formulations containing a hypnotic agent
IN190963B (ru) * 2000-06-20 2003-09-06 Ajanta Pharma Ltd
US20050020613A1 (en) 2002-09-20 2005-01-27 Alpharma, Inc. Sustained release opioid formulations and method of use
DE602004007315D1 (de) * 2003-03-03 2007-08-16 Personnes A Responsibilite Lim Stabilisierte pharmazeutische Zusammensetzung enthaltend einen NSAID und einen Prostaglandin
US20050129764A1 (en) * 2003-12-11 2005-06-16 Vergez Juan A. Osmotic device containing licofelone

Also Published As

Publication number Publication date
WO2007010559A3 (en) 2007-09-20
MX2008000967A (es) 2008-03-26
JP2009501785A (ja) 2009-01-22
DE202006020331U1 (de) 2008-09-18
CR9828A (es) 2008-07-31
BRPI0613547A2 (pt) 2011-01-18
NO20080697L (no) 2008-04-18
TNSN08018A1 (en) 2009-07-14
KR20080032209A (ko) 2008-04-14
DK200900115U1 (en) 2009-10-23
RS20080020A (en) 2009-05-06
CA2614850A1 (en) 2007-01-25
WO2007010559A2 (en) 2007-01-25
US20100204333A1 (en) 2010-08-12
EA200800370A1 (ru) 2008-06-30
AR055090A1 (es) 2007-08-08
AU2006271150A1 (en) 2007-01-25
EP1906933A2 (en) 2008-04-09
ZA200801592B (en) 2009-10-28
CN101227893A (zh) 2008-07-23

Similar Documents

Publication Publication Date Title
UA89684C2 (ru) Двухслойная фармацевтическая дозированная форма с модифицированным высвобождением нимесулида
SG151286A1 (en) 5-substituted-2-phenylamino-benzamide as mek inhibitor
HK1133596A1 (en) Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
EA200870368A1 (ru) Антибиотические композиции с модифицированным высвобождением и способ их получения
HRP20150196T1 (hr) Farmaceutske formulacije s ligandima receptora dopamina
HUP0100156A2 (hu) Foszfolipáz-A2 inhibitor hatású indolszármazékok és alkalmazásuk gyógyászati készítmények előállítására
RS20070511A (en) Modified release pharmaceutical compositions and processes thereof
RU2005115855A (ru) Композиция трамадола продлонгированного высвобождением с 24-часовым действием
EA200800783A1 (ru) Композиция тразодона для введения один раз в день
EA200400154A1 (ru) Новые лекарственные формы замещенного бензимидазола и способ их применения
MXPA05006194A (es) Metodo para utilizar una composicion de bebida.
MX2009003735A (es) Composicion en deposito inyectable y su procedimiento de preparacion.
MX2023004565A (es) Fosfato de vitamina d3 y sales farmaceuticamente aceptables de este, composiciones farmaceuticas que comprenden el compuesto y metodos para preparar el compuesto.
PT1265614E (pt) Nova forma galenica para administracao oral de libertacao prolongada de molsidomina
MXPA03005384A (es) Composiciones framaceuticas de un inhibidor de bomba de proton revestido no enterico con una combinacion de sal de bicarbonato y sal de carbonato.
CO5660084A1 (es) Nuevos derivados de fenilheteroalquilamina, proceso para su prepraracion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia
RS54791B1 (sr) Oralni sastav molsidomina sa produženim oslobađanjem za aterosklerozu
BRPI0513793A (pt) composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma condição em um mamìfero, formulação farmacêutica, e, composição farmacêutica
EA200970045A1 (ru) Фармацевтическая композиция для перорального введения плохо растворимого в воде активного вещества
WO2008025114A1 (en) Increasing atp availability by inhibition of creatine kinase (ck) leakage resulting from high-intensity exercise
CA2556802A1 (en) Increasing atp availability by inhibition of creatine kinase (ck) leakage resulting from high-intensity exercise