UA83633C2 - Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина - Google Patents

Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина

Info

Publication number
UA83633C2
UA83633C2 UAA200501303A UA2005001303A UA83633C2 UA 83633 C2 UA83633 C2 UA 83633C2 UA A200501303 A UAA200501303 A UA A200501303A UA 2005001303 A UA2005001303 A UA 2005001303A UA 83633 C2 UA83633 C2 UA 83633C2
Authority
UA
Ukraine
Prior art keywords
olanzapine
preparation
forms
solvates
anhydrous
Prior art date
Application number
UAA200501303A
Other languages
English (en)
Ukrainian (uk)
Inventor
Иордан Берта Котар
Франц Вречер
Мария Грчман
Original Assignee
Крка Товарна Здравил, Д.Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка Товарна Здравил, Д.Д., Ново Место filed Critical Крка Товарна Здравил, Д.Д., Ново Место
Publication of UA83633C2 publication Critical patent/UA83633C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение касается способа получения формы І оланзапина, кристаллизованной из смеси растворителей, которые включают 2-пропанол, сольваты оланзапина, а также применение сольвата оланзапина с 2-пропанолом для получения формы І оланзапина.
UAA200501303A 2002-07-15 2003-07-14 Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина UA83633C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200175A SI21270A (sl) 2002-07-15 2002-07-15 Kristalne oblike olanzapina in postopki za njihovo pripravo
PCT/SI2003/000024 WO2004006933A2 (en) 2002-07-15 2003-07-14 Crystal forms of olanzapine and processes for their preparation

Publications (1)

Publication Number Publication Date
UA83633C2 true UA83633C2 (ru) 2008-08-11

Family

ID=30113490

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200501303A UA83633C2 (ru) 2002-07-15 2003-07-14 Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина

Country Status (12)

Country Link
US (1) US7745429B2 (ru)
EP (1) EP1551414B1 (ru)
AU (1) AU2003256242A1 (ru)
CA (1) CA2493370C (ru)
EA (1) EA008055B1 (ru)
HR (1) HRP20050039B1 (ru)
NO (1) NO20050720L (ru)
PL (1) PL217081B1 (ru)
RS (1) RS53474B (ru)
SI (2) SI21270A (ru)
UA (1) UA83633C2 (ru)
WO (1) WO2004006933A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
US7323459B2 (en) * 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
AR047461A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Formacion, purificacion y uso de n-formilolanzapina
DE602005027308D1 (de) 2004-01-27 2011-05-19 Synthon Bv Stabile salze von olanzapin
SI1730153T1 (sl) * 2004-03-08 2011-11-30 KRKA@@tovarna@zdravil@@d@d@@Novo@mesto Izopropanol-vodni solvat olanzapina
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
GB0522473D0 (en) 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (ru) 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EG24221A (en) 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US5776928A (en) * 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
US6506746B2 (en) * 1995-05-30 2003-01-14 Eli Lilly And Company Method for treating cognitive dysfunction
ZA978515B (en) 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
CZ299247B6 (cs) 1996-09-23 2008-05-28 Eli Lilly And Company Olanzapin dihydrát D
JP2001517684A (ja) * 1997-09-30 2001-10-09 イーライ・リリー・アンド・カンパニー 性機能不全を処置するための方法
AU779452B2 (en) * 1999-12-28 2005-01-27 Cipla Limited New polymorphic forms of olanzapine
CA2420987A1 (en) 2000-08-31 2002-03-07 Dr. Reddy's Laboratories Ltd. Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Also Published As

Publication number Publication date
PL373845A1 (en) 2005-09-19
SI21270A (sl) 2004-02-29
AU2003256242A1 (en) 2004-02-02
US7745429B2 (en) 2010-06-29
EA200500188A1 (ru) 2005-06-30
EP1551414A2 (en) 2005-07-13
EP1551414B1 (en) 2013-11-27
WO2004006933A2 (en) 2004-01-22
CA2493370C (en) 2009-09-29
HRP20050039A2 (en) 2005-08-31
RS53474B (en) 2014-12-31
PL217081B1 (pl) 2014-06-30
WO2004006933A3 (en) 2004-04-01
EA008055B1 (ru) 2007-02-27
HRP20050039B1 (hr) 2014-10-10
RS20050023A (en) 2007-06-04
US20060040920A1 (en) 2006-02-23
SI1551414T1 (sl) 2014-04-30
NO20050720L (no) 2005-02-10
CA2493370A1 (en) 2004-01-22

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