UA83633C2 - Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина - Google Patents

Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина

Info

Publication number
UA83633C2
UA83633C2 UAA200501303A UA2005001303A UA83633C2 UA 83633 C2 UA83633 C2 UA 83633C2 UA A200501303 A UAA200501303 A UA A200501303A UA 2005001303 A UA2005001303 A UA 2005001303A UA 83633 C2 UA83633 C2 UA 83633C2
Authority
UA
Ukraine
Prior art keywords
olanzapine
preparation
forms
solvates
anhydrous
Prior art date
Application number
UAA200501303A
Other languages
English (en)
Ukrainian (uk)
Inventor
Иордан Берта Котар
Франц Вречер
Мария Грчман
Original Assignee
Крка Товарна Здравил, Д.Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка Товарна Здравил, Д.Д., Ново Место filed Critical Крка Товарна Здравил, Д.Д., Ново Место
Publication of UA83633C2 publication Critical patent/UA83633C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение касается способа получения формы І оланзапина, кристаллизованной из смеси растворителей, которые включают 2-пропанол, сольваты оланзапина, а также применение сольвата оланзапина с 2-пропанолом для получения формы І оланзапина.
UAA200501303A 2002-07-15 2003-07-14 Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина UA83633C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200175A SI21270A (sl) 2002-07-15 2002-07-15 Kristalne oblike olanzapina in postopki za njihovo pripravo
PCT/SI2003/000024 WO2004006933A2 (en) 2002-07-15 2003-07-14 Crystal forms of olanzapine and processes for their preparation

Publications (1)

Publication Number Publication Date
UA83633C2 true UA83633C2 (ru) 2008-08-11

Family

ID=30113490

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200501303A UA83633C2 (ru) 2002-07-15 2003-07-14 Способ получения формы и оланзапина, сольваты оланзапина и их применение в получении безводных форм оланзапина

Country Status (12)

Country Link
US (1) US7745429B2 (ru)
EP (1) EP1551414B1 (ru)
AU (1) AU2003256242A1 (ru)
CA (1) CA2493370C (ru)
EA (1) EA008055B1 (ru)
HR (1) HRP20050039B1 (ru)
NO (1) NO20050720L (ru)
PL (1) PL217081B1 (ru)
RS (1) RS53474B (ru)
SI (2) SI21270A (ru)
UA (1) UA83633C2 (ru)
WO (1) WO2004006933A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
EP1575962A1 (en) * 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
AR047460A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)
WO2005085256A1 (en) * 2004-03-08 2005-09-15 Krka, Tovarna Zdravil, D.D., Novo Mesto Isopropanol water solvate of olanzapine
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
GB0522473D0 (en) 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
US7834176B2 (en) * 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (ru) 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5776928A (en) * 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
US6506746B2 (en) * 1995-05-30 2003-01-14 Eli Lilly And Company Method for treating cognitive dysfunction
ID21924A (id) 1996-09-23 1999-08-12 Lilly Co Eli Olanzapin dihidrat d
ZA978515B (en) 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO1999016312A1 (en) * 1997-09-30 1999-04-08 Eli Lilly And Company Method for treating sexual dysfunction
AU779452B2 (en) * 1999-12-28 2005-01-27 Cipla Limited New polymorphic forms of olanzapine
JP2004507548A (ja) 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法

Also Published As

Publication number Publication date
CA2493370A1 (en) 2004-01-22
SI21270A (sl) 2004-02-29
PL217081B1 (pl) 2014-06-30
HRP20050039B1 (hr) 2014-10-10
US20060040920A1 (en) 2006-02-23
EA200500188A1 (ru) 2005-06-30
WO2004006933A3 (en) 2004-04-01
RS20050023A (en) 2007-06-04
RS53474B (en) 2014-12-31
WO2004006933A2 (en) 2004-01-22
SI1551414T1 (sl) 2014-04-30
CA2493370C (en) 2009-09-29
HRP20050039A2 (en) 2005-08-31
EP1551414A2 (en) 2005-07-13
EP1551414B1 (en) 2013-11-27
US7745429B2 (en) 2010-06-29
EA008055B1 (ru) 2007-02-27
AU2003256242A1 (en) 2004-02-02
NO20050720L (no) 2005-02-10
PL373845A1 (en) 2005-09-19

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