UA83437C2 - Способ получения фармацевтической композиции, содержащей венлафаксин, и композиция - Google Patents

Способ получения фармацевтической композиции, содержащей венлафаксин, и композиция Download PDF

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Publication number
UA83437C2
UA83437C2 UAA200700846A UAA200700846A UA83437C2 UA 83437 C2 UA83437 C2 UA 83437C2 UA A200700846 A UAA200700846 A UA A200700846A UA A200700846 A UAA200700846 A UA A200700846A UA 83437 C2 UA83437 C2 UA 83437C2
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UA
Ukraine
Prior art keywords
aza
aai
miyiza
iai
iaye
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UAA200700846A
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English (en)
Ukrainian (uk)
Inventor
Роберт Писек
Закель Мойца Сегула
Original Assignee
Крка, Товарна Здравил, Д.Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Крка, Товарна Здравил, Д.Д., Ново Место filed Critical Крка, Товарна Здравил, Д.Д., Ново Место
Publication of UA83437C2 publication Critical patent/UA83437C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтике, в частности к способу получения фармацевтической композиции, который включает следующие стадии: (1) получение дисперсии венлафаксина или соли венлафаксина в растворителе, в каком венлафаксин или соль венлафаксина имеют растворимость менее 25 г/литр при комнатной температуре; (2) превращение дисперсии, полученной на стадии (1), в форму частиц; (3) покрытие частиц, полученных на стадии (2), слоем полимера, который обеспечивает замедленное высвобождение действующего вещества. Изобретение относится также к композиции, полученной этим способом.
UAA200700846A 2004-07-28 2005-07-27 Способ получения фармацевтической композиции, содержащей венлафаксин, и композиция UA83437C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004036641A DE102004036641A1 (de) 2004-07-28 2004-07-28 Verzögert freisetzende pharmazeutische Zusammensetzung, die Venlafaxin enthält
PCT/EP2005/008149 WO2006010605A2 (en) 2004-07-28 2005-07-27 Sustained release pharmaceutical particulate composition comprising venlafaxine

Publications (1)

Publication Number Publication Date
UA83437C2 true UA83437C2 (ru) 2008-07-10

Family

ID=35106687

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200700846A UA83437C2 (ru) 2004-07-28 2005-07-27 Способ получения фармацевтической композиции, содержащей венлафаксин, и композиция

Country Status (16)

Country Link
EP (1) EP1778193B1 (ru)
AT (1) ATE381925T1 (ru)
CY (1) CY1107187T1 (ru)
DE (2) DE102004036641A1 (ru)
DK (1) DK1778193T3 (ru)
EA (1) EA009957B1 (ru)
ES (1) ES2299061T3 (ru)
HR (1) HRP20080007T3 (ru)
NO (1) NO20071139L (ru)
PL (1) PL1778193T3 (ru)
PT (1) PT1778193E (ru)
RS (1) RS50572B (ru)
SI (1) SI1778193T1 (ru)
UA (1) UA83437C2 (ru)
WO (1) WO2006010605A2 (ru)
ZA (1) ZA200701554B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722458B2 (en) * 2011-12-02 2020-07-28 Pegasus Laboratories, Inc. Amphipathic lipid-based sustained release compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146462A (en) * 2001-11-13 2015-02-26 Lycored Bio Ltd Prolonged-release preparations containing as an active compound and analapaxin hydrochloride
WO2003055475A1 (en) * 2002-01-03 2003-07-10 Lek Pharmaceutical And Chemical Company D.D. Controlled release pharmaceutical formulation containing venlafaxine
AU2003236947A1 (en) * 2002-06-07 2003-12-22 Ranbaxy Laboratories Limited Modified release, multiple unit drug delivery systems
WO2004047718A2 (en) * 2002-11-28 2004-06-10 Themis Laboratories Private Limited Process for manufacturing sustained release microbeads containing venlafaxine hci

Also Published As

Publication number Publication date
ATE381925T1 (de) 2008-01-15
EA200700159A1 (ru) 2007-06-29
DE602005004033D1 (de) 2008-02-07
WO2006010605A3 (en) 2006-09-21
DE602005004033T2 (de) 2009-01-02
EA009957B1 (ru) 2008-04-28
ES2299061T3 (es) 2008-05-16
RS50572B (sr) 2010-05-07
WO2006010605A2 (en) 2006-02-02
CY1107187T1 (el) 2012-10-24
NO20071139L (no) 2007-02-28
DE102004036641A1 (de) 2006-03-23
ZA200701554B (en) 2008-05-28
EP1778193B1 (en) 2007-12-26
DK1778193T3 (da) 2008-02-04
PT1778193E (pt) 2008-03-10
HRP20080007T3 (en) 2008-01-31
SI1778193T1 (sl) 2008-06-30
EP1778193A2 (en) 2007-05-02
PL1778193T3 (pl) 2008-05-30

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