EA200700159A1 - Фармацевтическая композиция с замедленным высвобождением, включающая венлафаксин - Google Patents

Фармацевтическая композиция с замедленным высвобождением, включающая венлафаксин

Info

Publication number
EA200700159A1
EA200700159A1 EA200700159A EA200700159A EA200700159A1 EA 200700159 A1 EA200700159 A1 EA 200700159A1 EA 200700159 A EA200700159 A EA 200700159A EA 200700159 A EA200700159 A EA 200700159A EA 200700159 A1 EA200700159 A1 EA 200700159A1
Authority
EA
Eurasian Patent Office
Prior art keywords
venlafaxine
pharmaceutical composition
venlafaxin
slowed
delivery
Prior art date
Application number
EA200700159A
Other languages
English (en)
Other versions
EA009957B1 (ru
Inventor
Роберт Писек
Силво Зупанциц
Закель Мойка Сегула
Original Assignee
Крка, Товарна Здравил, Д. Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка, Товарна Здравил, Д. Д., Ново Место filed Critical Крка, Товарна Здравил, Д. Д., Ново Место
Publication of EA200700159A1 publication Critical patent/EA200700159A1/ru
Publication of EA009957B1 publication Critical patent/EA009957B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Способ получения фармацевтической композиции, содержащей венлафаксин или его фармацевтически приемлемую соль, включающий стадии (1) получения дисперсии венлафаксина или соли венлафаксина в растворителе, в котором венлафаксин или его соли имеют растворимость менее 25 г/л при комнатной температуре; (2) преобразование дисперсии, полученной на стадии (1), в форму частиц; (3) покрывание частиц, полученных на стадии (2), слоем полимера, обеспечивающего замедленное высвобождение действующего вещества, а также фармацевтические композиции, полученные этим способом.
EA200700159A 2004-07-28 2005-07-27 Фармацевтическая композиция с замедленным высвобождением, включающая венлафаксин EA009957B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004036641A DE102004036641A1 (de) 2004-07-28 2004-07-28 Verzögert freisetzende pharmazeutische Zusammensetzung, die Venlafaxin enthält
PCT/EP2005/008149 WO2006010605A2 (en) 2004-07-28 2005-07-27 Sustained release pharmaceutical particulate composition comprising venlafaxine

Publications (2)

Publication Number Publication Date
EA200700159A1 true EA200700159A1 (ru) 2007-06-29
EA009957B1 EA009957B1 (ru) 2008-04-28

Family

ID=35106687

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700159A EA009957B1 (ru) 2004-07-28 2005-07-27 Фармацевтическая композиция с замедленным высвобождением, включающая венлафаксин

Country Status (16)

Country Link
EP (1) EP1778193B1 (ru)
AT (1) ATE381925T1 (ru)
CY (1) CY1107187T1 (ru)
DE (2) DE102004036641A1 (ru)
DK (1) DK1778193T3 (ru)
EA (1) EA009957B1 (ru)
ES (1) ES2299061T3 (ru)
HR (1) HRP20080007T3 (ru)
NO (1) NO20071139L (ru)
PL (1) PL1778193T3 (ru)
PT (1) PT1778193E (ru)
RS (1) RS50572B (ru)
SI (1) SI1778193T1 (ru)
UA (1) UA83437C2 (ru)
WO (1) WO2006010605A2 (ru)
ZA (1) ZA200701554B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722458B2 (en) * 2011-12-02 2020-07-28 Pegasus Laboratories, Inc. Amphipathic lipid-based sustained release compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146462A (en) * 2001-11-13 2015-02-26 Lycored Bio Ltd Prolonged-release preparations containing as an active compound and analapaxin hydrochloride
EP1474123A1 (en) * 2002-01-03 2004-11-10 LEK Pharmaceuticals D.D. Controlled release pharmaceutical formulation containing venlafaxine
CN1674877A (zh) * 2002-06-07 2005-09-28 兰贝克赛实验室有限公司 控释的多单位药物释放系统
PL377473A1 (pl) * 2002-11-28 2006-02-06 Themis Laboratories Private Limited Sposób produkcji mikropeletek o przedłużonym uwalnianiu zawierających chlorowodorek wenlafaksyny

Also Published As

Publication number Publication date
ATE381925T1 (de) 2008-01-15
EA009957B1 (ru) 2008-04-28
WO2006010605A2 (en) 2006-02-02
DK1778193T3 (da) 2008-02-04
DE602005004033T2 (de) 2009-01-02
RS50572B (sr) 2010-05-07
ZA200701554B (en) 2008-05-28
DE102004036641A1 (de) 2006-03-23
WO2006010605A3 (en) 2006-09-21
EP1778193B1 (en) 2007-12-26
CY1107187T1 (el) 2012-10-24
ES2299061T3 (es) 2008-05-16
DE602005004033D1 (de) 2008-02-07
NO20071139L (no) 2007-02-28
UA83437C2 (ru) 2008-07-10
PL1778193T3 (pl) 2008-05-30
PT1778193E (pt) 2008-03-10
SI1778193T1 (sl) 2008-06-30
HRP20080007T3 (en) 2008-01-31
EP1778193A2 (en) 2007-05-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ MD RU