UA82597C2 - Форма пролонгированного высвобождения гидрохлорида венлафаксина - Google Patents
Форма пролонгированного высвобождения гидрохлорида венлафаксина Download PDFInfo
- Publication number
- UA82597C2 UA82597C2 UAA200608949A UAA200608949A UA82597C2 UA 82597 C2 UA82597 C2 UA 82597C2 UA A200608949 A UAA200608949 A UA A200608949A UA A200608949 A UAA200608949 A UA A200608949A UA 82597 C2 UA82597 C2 UA 82597C2
- Authority
- UA
- Ukraine
- Prior art keywords
- mini
- tablets
- water
- venlafaxine hydrochloride
- tablet
- Prior art date
Links
- 229960002416 venlafaxine hydrochloride Drugs 0.000 title claims abstract description 47
- QYRYFNHXARDNFZ-UHFFFAOYSA-N venlafaxine hydrochloride Chemical compound [H+].[Cl-].C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 QYRYFNHXARDNFZ-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 238000013265 extended release Methods 0.000 title claims abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 9
- 239000008185 minitablet Substances 0.000 claims abstract description 56
- 239000000203 mixture Substances 0.000 claims abstract description 39
- 239000007903 gelatin capsule Substances 0.000 claims abstract description 7
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 40
- 229920001249 ethyl cellulose Polymers 0.000 claims description 40
- 239000001856 Ethyl cellulose Substances 0.000 claims description 39
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 38
- 238000000576 coating method Methods 0.000 claims description 25
- 239000011248 coating agent Substances 0.000 claims description 24
- 230000002035 prolonged effect Effects 0.000 claims description 19
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 18
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 18
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 18
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 18
- 239000003826 tablet Substances 0.000 claims description 18
- 239000002775 capsule Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 15
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 8
- 229920003169 water-soluble polymer Polymers 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 2
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 5
- 239000012730 sustained-release form Substances 0.000 description 19
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
- 239000012798 spherical particle Substances 0.000 description 16
- 238000013268 sustained release Methods 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 229960004688 venlafaxine Drugs 0.000 description 13
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 13
- 239000002552 dosage form Substances 0.000 description 12
- 239000004480 active ingredient Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 235000019359 magnesium stearate Nutrition 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000000454 talc Substances 0.000 description 8
- 229910052623 talc Inorganic materials 0.000 description 8
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 7
- 235000019441 ethanol Nutrition 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 210000002381 plasma Anatomy 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229940069328 povidone Drugs 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- -1 compound venlafaxine hydrochloride Chemical class 0.000 description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
- 239000007909 solid dosage form Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- LFQSCWFLJHTTHZ-WFVSFCRTSA-N deuteriooxyethane Chemical compound [2H]OCC LFQSCWFLJHTTHZ-WFVSFCRTSA-N 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000007888 film coating Substances 0.000 description 3
- 238000009501 film coating Methods 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 229920001600 hydrophobic polymer Polymers 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081735 acetylcellulose Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 231100000693 bioaccumulation Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960003750 ethyl chloride Drugs 0.000 description 1
- 230000006203 ethylation Effects 0.000 description 1
- 238000006200 ethylation reaction Methods 0.000 description 1
- 235000020937 fasting conditions Nutrition 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940049654 glyceryl behenate Drugs 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000013563 matrix tablet Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000004859 neutralization-reionization mass spectrometry Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005563 spheronization Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 229940022817 venlafaxine 150 mg Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Данное изобретение относится к форме пролонгированного высвобождения гидрохлорида венлафаксина в форме мини-таблеток, которыми заполненная твердая желатиновая капсула. Указанные мини-таблетки имеют ядро и внешнюю оболочку, составляющую 2-15 % общего веса мини-таблеток. Ядро указанных мини-таблеток включает гидрохлорид венлафаксина, микрокристаллическую целлюлозу и поливинил пирролидон, а оболочка включает полимер, нерастворимый в воде, и полимер, растворимый в воде. Изобретение также относится к способу получения такой формы.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN117MU2004 | 2004-02-04 | ||
| IN980MU2004 | 2004-09-13 | ||
| PCT/IN2004/000340 WO2005074895A1 (en) | 2004-02-04 | 2004-10-27 | Extended release coated microtablets of venlafaxine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82597C2 true UA82597C2 (ru) | 2008-04-25 |
Family
ID=34809925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200608949A UA82597C2 (ru) | 2004-02-04 | 2004-10-27 | Форма пролонгированного высвобождения гидрохлорида венлафаксина |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7807195B2 (ru) |
| EP (1) | EP1711169B1 (ru) |
| JP (1) | JP2007520547A (ru) |
| KR (1) | KR20070000439A (ru) |
| AT (1) | ATE361743T1 (ru) |
| AU (1) | AU2004315136B2 (ru) |
| BR (1) | BRPI0418283A (ru) |
| CA (1) | CA2555295C (ru) |
| CY (1) | CY1106741T1 (ru) |
| DE (1) | DE602004006443T2 (ru) |
| DK (1) | DK1711169T3 (ru) |
| ES (1) | ES2287813T3 (ru) |
| HK (1) | HK1091137A1 (ru) |
| HR (1) | HRP20070353T3 (ru) |
| IL (1) | IL177243A0 (ru) |
| MX (1) | MXPA06008854A (ru) |
| NO (1) | NO20063809L (ru) |
| NZ (1) | NZ548504A (ru) |
| PL (1) | PL1711169T3 (ru) |
| PT (1) | PT1711169E (ru) |
| RU (1) | RU2340331C2 (ru) |
| SI (1) | SI1711169T1 (ru) |
| UA (1) | UA82597C2 (ru) |
| WO (1) | WO2005074895A1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146462A (en) | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
| EP1572160A2 (en) * | 2002-11-28 | 2005-09-14 | Themis Laboratories Private Limited | Process for manufacturing sustained release microbeads containing venlafaxine hci |
| WO2006136927A1 (en) * | 2005-06-22 | 2006-12-28 | Glenmark Pharmaceuticals Limited | Extended release formulations comprising venlafaxine |
| EP1906935A4 (en) * | 2005-07-28 | 2010-10-20 | Reddys Lab Ltd Dr | VENLAFAXIN COMPOSITIONS WITH EXTENDED RELEASE |
| US20090175934A1 (en) * | 2006-03-08 | 2009-07-09 | Jubilant Organosys Ltd. | Extended Release Pharmaceutical Formulation of Venlafaxine and Method of Manufacturing the Same |
| WO2007112574A1 (en) * | 2006-04-03 | 2007-10-11 | Isa Odidi | Extended release composition of venlafaxine |
| CA2648278C (en) * | 2006-04-03 | 2019-05-28 | Isa Odidi | Drug delivery composition |
| WO2007129329A2 (en) * | 2006-05-08 | 2007-11-15 | Jubilant Organosys Limited | Extended release pharmaceutical formulation comprising venlafaxine hydrochloride |
| US20100120723A1 (en) * | 2006-12-20 | 2010-05-13 | Mostafa Akbarieh | Pharmaceutical composition comprising a hot-melt granulated lubricant |
| US20100179110A1 (en) * | 2006-12-20 | 2010-07-15 | Mostafa Akbarieh | Composition Containing a Bisphosphonic Acid in Combination with Vitamin D |
| TWI391150B (zh) * | 2008-01-22 | 2013-04-01 | Taiwan Biotech Co Ltd | 腸溶性長效塗覆芯與藥物劑型及其製造方法 |
| CN101756934A (zh) * | 2008-12-10 | 2010-06-30 | 上海复星普适医药科技有限公司 | 文拉法辛缓释制剂的制备方法 |
| KR101787481B1 (ko) | 2010-10-21 | 2017-10-18 | 롯데정밀화학 주식회사 | 장용성 경질 캡슐용 조성물 및 상기 조성물을 사용하여 제조된 장용성 경질 캡슐 |
| WO2012104852A1 (en) | 2011-01-31 | 2012-08-09 | Serotech, Llc | Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder |
| JP6860502B2 (ja) | 2015-12-25 | 2021-04-14 | 富士フイルム富山化学株式会社 | １−（３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピル）アゼチジン−３−オールまたはその塩を含む錠剤 |
| KR102062052B1 (ko) * | 2018-03-20 | 2020-01-03 | 일양약품주식회사 | 베타네콜 서방성 제제 및 이의 제조방법 |
| KR20230067863A (ko) | 2021-11-10 | 2023-05-17 | 박찬호 | 스마트 계량도구 및 이를 이용한 요리보조 시스템 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4153677A (en) * | 1978-05-18 | 1979-05-08 | Sterling Drug Inc. | Controlled-release composition |
| US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| US6440457B1 (en) | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| US6274171B1 (en) * | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| PE57198A1 (es) | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
| UA77145C2 (en) | 1997-11-05 | 2006-11-15 | Wyeth Corp | Extended release dosage formulation |
| HU228771B1 (en) * | 1998-05-15 | 2013-05-28 | Warner Lambert Co | Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same |
| AU1789301A (en) | 1999-11-22 | 2001-06-04 | Alza Corporation | Osmotic dosage form comprising first and second |
| US6346269B1 (en) * | 2000-05-08 | 2002-02-12 | Standard Chem. & Pharm. Co., Ltd. | Method for preparing an oral formulation containing acid-sensitive drugs and oral formulation made thereby |
| US6350471B1 (en) * | 2000-05-31 | 2002-02-26 | Pharma Pass Llc | Tablet comprising a delayed release coating |
| EP1385486A4 (en) * | 2001-04-18 | 2006-05-17 | Nostrum Pharmaceuticals Inc | NEW COATING OF SLOW RELEASE PHARMACEUTICAL COMPOSITION |
| US20030091634A1 (en) * | 2001-09-14 | 2003-05-15 | Pawan Seth | Delayed release tablet of venlafaxin |
| AU2002358270A1 (en) | 2001-12-20 | 2003-07-09 | Pharmacia Corporation | Zero-order sustained released dosage forms and method of making the same |
| AU2002217373A1 (en) * | 2002-01-03 | 2003-07-15 | Lek Pharmaceutical And Chemical Company D.D. | Controlled release pharmaceutical formulation containing venlafaxine |
| EP1487429A2 (en) * | 2002-03-28 | 2004-12-22 | Synthon B.V. | Compositions of venlafaxine base |
| US6696496B2 (en) * | 2002-03-28 | 2004-02-24 | Synthon Bv | Low water-soluble venlafaxine salts |
| IL149055A0 (en) * | 2002-04-09 | 2002-11-10 | Karma Pharm Ltd | Extended release composition comprising as active compound venlafaxine hydrochloride |
| BR0312445A (pt) * | 2002-06-07 | 2005-05-10 | Ranbaxy Lab Ltd | Sistemas multiunitários para disponibilização de fármaco de liberação modificada |
| US8216609B2 (en) * | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| US7058999B2 (en) * | 2002-10-24 | 2006-06-13 | Paramount Bed Co., Ltd. | Electric bed and control apparatus and control method therefor |
| US6703044B1 (en) * | 2002-10-25 | 2004-03-09 | Dexcel Pharma Tech, Ltd | Venlafaxine formulations |
| AU2003274655A1 (en) * | 2002-10-25 | 2004-05-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions containing venlafaxine |
| WO2004069228A2 (en) * | 2003-02-07 | 2004-08-19 | Omega Farma Ehf. | Sustained release formulations of venlafaxine |
| ATE336988T1 (de) * | 2003-07-30 | 2006-09-15 | Pharmathen Sa | Venlafaxine hydrochloridformulierungen mit verzögerter freisetzung |
| US7016014B2 (en) * | 2004-02-27 | 2006-03-21 | Asml Netherlands B.V | Lithographic apparatus and device manufacturing method |
-
2004
- 2004-10-27 DK DK04821278T patent/DK1711169T3/da active
- 2004-10-27 PL PL04821278T patent/PL1711169T3/pl unknown
- 2004-10-27 UA UAA200608949A patent/UA82597C2/ru unknown
- 2004-10-27 MX MXPA06008854A patent/MXPA06008854A/es active IP Right Grant
- 2004-10-27 KR KR1020067014903A patent/KR20070000439A/ko not_active Application Discontinuation
- 2004-10-27 JP JP2006552018A patent/JP2007520547A/ja active Pending
- 2004-10-27 PT PT04821278T patent/PT1711169E/pt unknown
- 2004-10-27 WO PCT/IN2004/000340 patent/WO2005074895A1/en active IP Right Grant
- 2004-10-27 ES ES04821278T patent/ES2287813T3/es active Active
- 2004-10-27 AT AT04821278T patent/ATE361743T1/de not_active IP Right Cessation
- 2004-10-27 SI SI200430372T patent/SI1711169T1/sl unknown
- 2004-10-27 EP EP04821278A patent/EP1711169B1/en active Active
- 2004-10-27 RU RU2006129034/15A patent/RU2340331C2/ru not_active IP Right Cessation
- 2004-10-27 DE DE602004006443T patent/DE602004006443T2/de not_active Expired - Fee Related
- 2004-10-27 NZ NZ548504A patent/NZ548504A/en unknown
- 2004-10-27 AU AU2004315136A patent/AU2004315136B2/en not_active Ceased
- 2004-10-27 BR BRPI0418283-9A patent/BRPI0418283A/pt not_active IP Right Cessation
- 2004-10-27 CA CA2555295A patent/CA2555295C/en not_active Expired - Fee Related
-
2005
- 2005-01-07 US US11/031,266 patent/US7807195B2/en not_active Expired - Fee Related
-
2006
- 2006-08-02 IL IL177243A patent/IL177243A0/en unknown
- 2006-08-25 NO NO20063809A patent/NO20063809L/no not_active Application Discontinuation
- 2006-11-20 HK HK06112748A patent/HK1091137A1/xx not_active IP Right Cessation
-
2007
- 2007-07-19 CY CY20071100959T patent/CY1106741T1/el unknown
- 2007-08-08 HR HR20070353T patent/HRP20070353T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ548504A (en) | 2009-03-31 |
| PT1711169E (pt) | 2007-07-23 |
| CA2555295A1 (en) | 2005-08-18 |
| EP1711169A1 (en) | 2006-10-18 |
| ATE361743T1 (de) | 2007-06-15 |
| ES2287813T3 (es) | 2007-12-16 |
| JP2007520547A (ja) | 2007-07-26 |
| MXPA06008854A (es) | 2007-01-23 |
| CY1106741T1 (el) | 2012-05-23 |
| HRP20070353T3 (en) | 2008-01-31 |
| DE602004006443T2 (de) | 2008-01-10 |
| PL1711169T3 (pl) | 2007-10-31 |
| DE602004006443D1 (de) | 2007-06-21 |
| AU2004315136A1 (en) | 2005-08-18 |
| RU2340331C2 (ru) | 2008-12-10 |
| AU2004315136B2 (en) | 2010-06-17 |
| NO20063809L (no) | 2006-08-25 |
| HK1091137A1 (en) | 2007-01-12 |
| RU2006129034A (ru) | 2008-03-10 |
| DK1711169T3 (da) | 2007-09-17 |
| IL177243A0 (en) | 2006-12-10 |
| EP1711169B1 (en) | 2007-05-09 |
| US20050169985A1 (en) | 2005-08-04 |
| BRPI0418283A (pt) | 2007-05-02 |
| WO2005074895A1 (en) | 2005-08-18 |
| SI1711169T1 (sl) | 2007-10-31 |
| US7807195B2 (en) | 2010-10-05 |
| KR20070000439A (ko) | 2007-01-02 |
| CA2555295C (en) | 2011-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4758064B2 (ja) | 有効物質を徐放する３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノール含有医薬 | |
| US7807195B2 (en) | Extended release formulation of venlafaxine hydrochloride | |
| CA2344372C (en) | Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same | |
| EP2373319B1 (en) | Sustained release pharmaceutical composition of quetiapine and process for preparation thereof | |
| MX2008002795A (es) | Composicion farmaceutica de metformina de liberacion extendida y proceso para producirla. | |
| US20100151018A1 (en) | Sustained-release levetiracetam composition and preparation process | |
| US20170231927A1 (en) | Pharmaceutical compositions of memantine | |
| WO2004056336A2 (en) | Controlled release, multiple unit drug delivery systems | |
| KR20060136409A (ko) | 벤라팍신 히드로클로라이드의 방출연장형 코팅 미니정제 | |
| WO2005084636A2 (en) | A process for the preparation of controlled-release pharmaceutical composition of metoprolol | |
| EP2533766B1 (en) | Pharmaceutical mini-tablets for sustained release of flecainide acetate | |
| EP3630074B1 (en) | Multiparticulate oral dosage form providing prolonged release of tapentadol | |
| US20080118554A1 (en) | Pharmaceutical compositions comprising a combination of piperidinoalkanol and decongestant | |
| JP5919173B2 (ja) | 徐放性塩酸アンブロキソール口腔内崩壊錠 | |
| JP2008115083A (ja) | 塩酸トラマドール含有コーティング顆粒 | |
| MXPA01002821A (en) | Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same | |
| WO2006136927A1 (en) | Extended release formulations comprising venlafaxine |