UA82214C2 - Novel anticonvulsant derivative salts - Google Patents
Novel anticonvulsant derivative salts Download PDFInfo
- Publication number
- UA82214C2 UA82214C2 UAA200507241A UA2005007241A UA82214C2 UA 82214 C2 UA82214 C2 UA 82214C2 UA A200507241 A UAA200507241 A UA A200507241A UA 2005007241 A UA2005007241 A UA 2005007241A UA 82214 C2 UA82214 C2 UA 82214C2
- Authority
- UA
- Ukraine
- Prior art keywords
- salt
- formula
- compound
- differs
- topiramate
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 121
- 239000001961 anticonvulsive agent Substances 0.000 title abstract description 7
- 230000001773 anti-convulsant effect Effects 0.000 title abstract description 5
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- 238000000034 method Methods 0.000 claims abstract description 38
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 193
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims description 65
- 229960004394 topiramate Drugs 0.000 claims description 64
- 239000003960 organic solvent Substances 0.000 claims description 53
- -1 alkali metal salt Chemical class 0.000 claims description 42
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 36
- 159000000000 sodium salts Chemical class 0.000 claims description 27
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 26
- 229910052783 alkali metal Inorganic materials 0.000 claims description 21
- 239000004381 Choline salt Substances 0.000 claims description 16
- 235000019417 choline salt Nutrition 0.000 claims description 16
- 159000000003 magnesium salts Chemical class 0.000 claims description 16
- 238000001556 precipitation Methods 0.000 claims description 16
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
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- 150000003248 quinolines Chemical class 0.000 claims description 15
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
- VEKVPJSPZRTTGR-WGAVTJJLSA-N potassium;[(3as,5ar,8ar,8bs)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methoxysulfonylazanide Chemical class [K+].C1O[C@@]2(COS([NH-])(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 VEKVPJSPZRTTGR-WGAVTJJLSA-N 0.000 description 1
- CUQOHAYJWVTKDE-UHFFFAOYSA-N potassium;butan-1-olate Chemical compound [K+].CCCC[O-] CUQOHAYJWVTKDE-UHFFFAOYSA-N 0.000 description 1
- AWDMDDKZURRKFG-UHFFFAOYSA-N potassium;propan-1-olate Chemical compound [K+].CCC[O-] AWDMDDKZURRKFG-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- RCOSUMRTSQULBK-UHFFFAOYSA-N sodium;propan-1-olate Chemical compound [Na+].CCC[O-] RCOSUMRTSQULBK-UHFFFAOYSA-N 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Изобретение касается фармацевтически приемлемых солей противосудорожных производных, способов получения и фармацевтических композиций, которые содержат указанные соли, полезные в лечении эпилепсии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/336,435 US7041650B2 (en) | 2001-07-09 | 2003-01-03 | Anticonvulsant derivative salts |
| PCT/US2003/041732 WO2004063210A1 (en) | 2003-01-03 | 2003-12-30 | Novel anticonvulsant derivative salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82214C2 true UA82214C2 (en) | 2008-03-25 |
Family
ID=32710935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200507241A UA82214C2 (en) | 2003-01-03 | 2003-12-30 | Novel anticonvulsant derivative salts |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7041650B2 (ru) |
| EP (1) | EP1581545A1 (ru) |
| JP (1) | JP2006514071A (ru) |
| KR (1) | KR20050092035A (ru) |
| CN (1) | CN100528888C (ru) |
| AU (1) | AU2003300149A1 (ru) |
| CA (1) | CA2511682A1 (ru) |
| HR (1) | HRP20050603A2 (ru) |
| IL (1) | IL169505A0 (ru) |
| MX (1) | MXPA05007253A (ru) |
| NO (1) | NO20053673L (ru) |
| NZ (1) | NZ540696A (ru) |
| PL (1) | PL377766A1 (ru) |
| RU (1) | RU2330041C2 (ru) |
| UA (1) | UA82214C2 (ru) |
| WO (1) | WO2004063210A1 (ru) |
| ZA (1) | ZA200506167B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA78211C2 (en) * | 2001-07-09 | 2007-03-15 | Ortho Mcneil Pharm Inc | Salts of fructopyranose derivatives as anticonvulsant |
| US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
| US20060233892A1 (en) * | 2005-04-19 | 2006-10-19 | Curt Hendrix | Topiramate compositions for treatment of headache |
| US20090076128A1 (en) * | 2007-09-15 | 2009-03-19 | Protia Llc | Deuterium-enriched topiramate |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56108787A (en) * | 1980-01-31 | 1981-08-28 | Sato Yakugaku Kenkyusho:Kk | Camptothecin coline salt and its preparation |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4751220A (en) * | 1986-12-19 | 1988-06-14 | E. R. Squibb & Sons, Inc. | Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid |
| US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| AU651244B2 (en) * | 1991-09-19 | 1994-07-14 | Mcneilab, Inc. | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-D- fructopyranose and (1-methylcyclohexyl)methanol |
| US5242942A (en) * | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| US5498629A (en) * | 1993-12-23 | 1996-03-12 | Ortho Pharmaceutical Corporation | Anticonvulsant pseudofructopyranose sulfamates |
| US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| US6541520B1 (en) | 1998-08-05 | 2003-04-01 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| BR0008477A (pt) * | 1999-02-24 | 2002-01-22 | Univ Cincinnati | Método para tratar um distúrbio de controle do impulso |
| UA78211C2 (en) | 2001-07-09 | 2007-03-15 | Ortho Mcneil Pharm Inc | Salts of fructopyranose derivatives as anticonvulsant |
| US6559293B1 (en) | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
-
2003
- 2003-01-03 US US10/336,435 patent/US7041650B2/en not_active Expired - Lifetime
- 2003-12-30 EP EP03800404A patent/EP1581545A1/en not_active Withdrawn
- 2003-12-30 KR KR1020057012509A patent/KR20050092035A/ko not_active Application Discontinuation
- 2003-12-30 RU RU2005120782/04A patent/RU2330041C2/ru active
- 2003-12-30 CA CA002511682A patent/CA2511682A1/en not_active Abandoned
- 2003-12-30 UA UAA200507241A patent/UA82214C2/uk unknown
- 2003-12-30 CN CNB2003801081824A patent/CN100528888C/zh not_active Expired - Fee Related
- 2003-12-30 JP JP2004566659A patent/JP2006514071A/ja active Pending
- 2003-12-30 AU AU2003300149A patent/AU2003300149A1/en not_active Abandoned
- 2003-12-30 PL PL377766A patent/PL377766A1/pl not_active Application Discontinuation
- 2003-12-30 MX MXPA05007253A patent/MXPA05007253A/es active IP Right Grant
- 2003-12-30 NZ NZ540696A patent/NZ540696A/en unknown
- 2003-12-30 WO PCT/US2003/041732 patent/WO2004063210A1/en active Application Filing
-
2005
- 2005-06-28 HR HR20050603A patent/HRP20050603A2/xx not_active Application Discontinuation
- 2005-07-03 IL IL169505A patent/IL169505A0/en unknown
- 2005-07-29 NO NO20053673A patent/NO20053673L/no not_active Application Discontinuation
- 2005-08-02 ZA ZA200506167A patent/ZA200506167B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003300149A1 (en) | 2004-08-10 |
| IL169505A0 (en) | 2007-07-04 |
| CA2511682A1 (en) | 2004-07-29 |
| ZA200506167B (en) | 2007-03-28 |
| JP2006514071A (ja) | 2006-04-27 |
| CN100528888C (zh) | 2009-08-19 |
| WO2004063210A1 (en) | 2004-07-29 |
| US7041650B2 (en) | 2006-05-09 |
| MXPA05007253A (es) | 2005-12-14 |
| KR20050092035A (ko) | 2005-09-16 |
| PL377766A1 (pl) | 2006-02-20 |
| NZ540696A (en) | 2007-11-30 |
| EP1581545A1 (en) | 2005-10-05 |
| CN1735626A (zh) | 2006-02-15 |
| NO20053673L (no) | 2005-09-30 |
| NO20053673D0 (no) | 2005-07-29 |
| HRP20050603A2 (en) | 2006-07-31 |
| US20030176362A1 (en) | 2003-09-18 |
| RU2330041C2 (ru) | 2008-07-27 |
| RU2005120782A (ru) | 2006-01-20 |
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