UA70911C2 - Поліпептид ожиріння (варіанти), відповідні нуклеїнові кислоти (варіанти) та фармацевтична композиція - Google Patents

Поліпептид ожиріння (варіанти), відповідні нуклеїнові кислоти (варіанти) та фармацевтична композиція

Info

Publication number
UA70911C2
UA70911C2 UA97031161A UA97031161A UA70911C2 UA 70911 C2 UA70911 C2 UA 70911C2 UA 97031161 A UA97031161 A UA 97031161A UA 97031161 A UA97031161 A UA 97031161A UA 70911 C2 UA70911 C2 UA 70911C2
Authority
UA
Ukraine
Prior art keywords
body weight
present
variants
modulators
polypeptide
Prior art date
Application number
UA97031161A
Other languages
English (en)
Russian (ru)
Inventor
Джеффрі М. Фрідмен
Ійінг Зенг
Рікардо Проінка
Джеффрі Л. Халес
Стіфен К. Берлей
Маргеріта Меффей
Кітен Гейджвела
Original Assignee
Дзе Рокефеллер Юніверсіті
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/292,345 external-priority patent/US6001968A/en
Priority claimed from US08/438,431 external-priority patent/US6429290B1/en
Priority claimed from US08/483,211 external-priority patent/US6309853B1/en
Application filed by Дзе Рокефеллер Юніверсіті filed Critical Дзе Рокефеллер Юніверсіті
Publication of UA70911C2 publication Critical patent/UA70911C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Винахід стосується контролю маси тіла тварин за допомогою білків ожиріння (Ож) і нуклеїнових кислот, які експресують ці білки. У ширшому контексті винахід стосується виявлення нуклеотидних послідовностей генів, що кодують такі білки. Ці нуклеотидні послідовності відповідають мишачому і людському генам Ож, які виконують критичну роль в регуляції маси тіла і ожиріння. Попередні дані свідчать про те, що поліпептиди, кодовані вказаними генами, функціонують подібно гормонам. У винаході також наведені молекулярні зонди і праймери для ампліфікації в полімеразній ланцюговій реакції (ПЛР). Описано також клонувальний вектор, що містить вказані послідовності разом із послідовностями, які контролюють його експресію. Далі описані клітини бактерій або ссавців трансфіковані відповідним експресувальним вектором і наводиться можливе застосування вказаних генних конструкцій. Описані також антитіла до поліпептиду гена Ож. Запропонований метод дозволяє контролювати масу тіла тварин. Приведені послідовності генів, що кодують дві ізоформи відповідних поліпептидів миші і людини.
UA97031161A 1994-08-17 1995-08-17 Поліпептид ожиріння (варіанти), відповідні нуклеїнові кислоти (варіанти) та фармацевтична композиція UA70911C2 (uk)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/292,345 US6001968A (en) 1994-08-17 1994-08-17 OB polypeptides, modified forms and compositions
US08/347,563 US5935810A (en) 1994-08-17 1994-11-30 Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof
US08/438,431 US6429290B1 (en) 1994-08-17 1995-05-10 OB polypeptides, modified forms and derivatives
US08/483,211 US6309853B1 (en) 1994-08-17 1995-06-07 Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
PCT/US1995/010479 WO1996005309A2 (en) 1994-08-17 1995-08-17 Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
UA70911C2 true UA70911C2 (uk) 2004-11-15

Family

ID=46507740

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97031161A UA70911C2 (uk) 1994-08-17 1995-08-17 Поліпептид ожиріння (варіанти), відповідні нуклеїнові кислоти (варіанти) та фармацевтична композиція

Country Status (5)

Country Link
KR (1) KR100584177B1 (uk)
BR (1) BRPI9508596B1 (uk)
PE (1) PE47396A1 (uk)
RS (1) RS50274B (uk)
UA (1) UA70911C2 (uk)

Also Published As

Publication number Publication date
YU54995A (sh) 1998-05-15
RS50274B (sr) 2009-07-15
PE47396A1 (es) 1996-12-02
BRPI9508596B1 (pt) 2018-11-27
KR970705631A (ko) 1997-10-09
KR100584177B1 (ko) 2006-10-24

Similar Documents

Publication Publication Date Title
MX9701200A (es) Moduladores de peso del cuerpo, acidos nucleicos y proteinas correspondientes y sus usos en diagnostico y terapeuticos.
IL188522A0 (en) Modulators of body weight, corresponding nucleic acids and proteins and diagnostic and therapeutic uses thereof
Erdile et al. Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication
US8710015B2 (en) Tropoelastin derivatives
Tabuchi et al. REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation
AU2008329563A1 (en) Methods of inducing pluripotency involving Oct4 protein
AU2008329562A1 (en) Methods of inducing pluripotency involving Sox2 protein
IE911914A1 (en) Novel neurotropic growth factors comprising a homeobox¹peptide
CA2195090A1 (en) Lkp pilin structural genes and operon of nontypable haemophilus influenzae
Prinz et al. Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5
Lars et al. The human lα1 and lα2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of Cα1 and Cα2 germline transcripts
JO1694B1 (en) New chemical products
UA70911C2 (uk) Поліпептид ожиріння (варіанти), відповідні нуклеїнові кислоти (варіанти) та фармацевтична композиція
HUT52154A (en) Recombinant interleukin-2 hybrid proteins.
Paine et al. Carboxyl-region of tuftelin mediates self-assembly
CN117120602A (zh) 分裂的cas12系统及其使用方法
Elder et al. Targeting of Sp1 to a non-Sp1 site in the human neurofilament (H) promoter via an intermediary DNA-binding protein
US7193043B1 (en) Tropoelastin derivatives
CA2694222A1 (en) Insulin secretion inducer, and accelerator for increasing the number of pancreatic .beta.-cells
US20030186905A1 (en) Cis-acting regulatory nucleic acid sequences in the parathyroid hormone3' -untranslated region
WO2023178280A2 (en) Compositions and methods for modulating alpha-synuclein expression
CN117904204A (zh) 一种携带Pdxl、Ngn3和MafA基因的重组腺相关病毒质粒pAAV8-M3及其构建与应用
Barton et al. Basic concepts in molecular biology
JP2003061672A (ja) 新規ヒトｂｍｃｃ１遺伝子
Ross Evolution of a transcription factor: Analysis of Oct2 from the channel catfish, Ictalurus punctatus