UA66748C2 - Phenyl substituted 4-azasteroids fluroderivatives, methods for the preparation thereof (variants) and pharmaceutical composition based thereon - Google Patents
Phenyl substituted 4-azasteroids fluroderivatives, methods for the preparation thereof (variants) and pharmaceutical composition based thereonInfo
- Publication number
- UA66748C2 UA66748C2 UA97062805A UA97062805A UA66748C2 UA 66748 C2 UA66748 C2 UA 66748C2 UA 97062805 A UA97062805 A UA 97062805A UA 97062805 A UA97062805 A UA 97062805A UA 66748 C2 UA66748 C2 UA 66748C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- fluroderivatives
- azasteroids
- variants
- preparation
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 150000000520 4-azasteroids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9518858.7A GB9518858D0 (en) | 1995-09-14 | 1995-09-14 | Phenylsubstituted 4-azasteroid fluoroderivatives |
| PCT/EP1996/003518 WO1997010257A1 (en) | 1995-09-14 | 1996-08-09 | Phenylsubstituted 4-azasteroid fluoroderivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA66748C2 true UA66748C2 (en) | 2004-06-15 |
Family
ID=10780746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA97062805A UA66748C2 (en) | 1995-09-14 | 1996-08-09 | Phenyl substituted 4-azasteroids fluroderivatives, methods for the preparation thereof (variants) and pharmaceutical composition based thereon |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5922728A (pl) |
| EP (1) | EP0793671B1 (pl) |
| JP (1) | JPH10509188A (pl) |
| KR (1) | KR100448745B1 (pl) |
| CN (1) | CN1104439C (pl) |
| AR (1) | AR004511A1 (pl) |
| AT (1) | ATE189681T1 (pl) |
| AU (1) | AU715858B2 (pl) |
| BR (1) | BR9606638A (pl) |
| CA (1) | CA2204002A1 (pl) |
| CZ (1) | CZ291450B6 (pl) |
| DE (1) | DE69606623T2 (pl) |
| DK (1) | DK0793671T3 (pl) |
| EA (1) | EA000362B1 (pl) |
| ES (1) | ES2144765T3 (pl) |
| GB (1) | GB9518858D0 (pl) |
| GR (1) | GR3033315T3 (pl) |
| HU (1) | HUP9702038A3 (pl) |
| IL (1) | IL120742A (pl) |
| MY (1) | MY116271A (pl) |
| NO (1) | NO309527B1 (pl) |
| NZ (1) | NZ316060A (pl) |
| PL (1) | PL185196B1 (pl) |
| PT (1) | PT793671E (pl) |
| TW (1) | TW357149B (pl) |
| UA (1) | UA66748C2 (pl) |
| WO (1) | WO1997010257A1 (pl) |
| ZA (1) | ZA967631B (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548491B2 (en) * | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| WO2001062259A1 (en) | 2000-02-25 | 2001-08-30 | Hollis Eden Pharmaceuticals | Method of treatment of prostate cancer |
| US7402577B2 (en) * | 2001-10-03 | 2008-07-22 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
| AU2004259664B2 (en) * | 2003-06-30 | 2009-05-28 | Merck Sharp & Dohme Corp. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
| CA2530048A1 (en) * | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
| WO2005005606A2 (en) | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
| EP1641535A4 (en) * | 2003-06-30 | 2008-05-14 | Merck & Co Inc | 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS |
| CN103787894B (zh) * | 2014-02-08 | 2015-09-16 | 济南大学 | 从甲苯二异氰酸酯制备过程中形成的残渣废料中回收甲苯二胺的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9002922D0 (en) * | 1990-02-09 | 1990-04-04 | Erba Carlo Spa | 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation |
| GB9216284D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives |
| GB9216329D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives |
| GB9608045D0 (en) * | 1996-04-18 | 1996-06-19 | Pharmacia Spa | Process for preparing steroids having a carboxamide side-chain |
| US5686501A (en) * | 1996-04-19 | 1997-11-11 | Foamex L.P. | Breathable open cell urethane polymers |
-
1995
- 1995-09-14 GB GBGB9518858.7A patent/GB9518858D0/en active Pending
-
1996
- 1996-08-09 ES ES96928436T patent/ES2144765T3/es not_active Expired - Lifetime
- 1996-08-09 PL PL96320114A patent/PL185196B1/pl not_active IP Right Cessation
- 1996-08-09 CN CN96191076A patent/CN1104439C/zh not_active Expired - Fee Related
- 1996-08-09 BR BR9606638A patent/BR9606638A/pt not_active Application Discontinuation
- 1996-08-09 IL IL12074296A patent/IL120742A/en not_active IP Right Cessation
- 1996-08-09 CZ CZ19971460A patent/CZ291450B6/cs not_active IP Right Cessation
- 1996-08-09 AT AT96928436T patent/ATE189681T1/de not_active IP Right Cessation
- 1996-08-09 KR KR1019970703203A patent/KR100448745B1/ko not_active Expired - Fee Related
- 1996-08-09 PT PT96928436T patent/PT793671E/pt unknown
- 1996-08-09 EA EA199700063A patent/EA000362B1/ru not_active IP Right Cessation
- 1996-08-09 AU AU68205/96A patent/AU715858B2/en not_active Ceased
- 1996-08-09 DK DK96928436T patent/DK0793671T3/da active
- 1996-08-09 EP EP96928436A patent/EP0793671B1/en not_active Expired - Lifetime
- 1996-08-09 UA UA97062805A patent/UA66748C2/xx unknown
- 1996-08-09 JP JP9511593A patent/JPH10509188A/ja not_active Withdrawn
- 1996-08-09 DE DE69606623T patent/DE69606623T2/de not_active Expired - Fee Related
- 1996-08-09 NZ NZ316060A patent/NZ316060A/xx unknown
- 1996-08-09 HU HU9702038A patent/HUP9702038A3/hu unknown
- 1996-08-09 US US08/836,052 patent/US5922728A/en not_active Expired - Fee Related
- 1996-08-09 CA CA002204002A patent/CA2204002A1/en not_active Abandoned
- 1996-08-09 WO PCT/EP1996/003518 patent/WO1997010257A1/en not_active Ceased
- 1996-09-05 TW TW085110841A patent/TW357149B/zh active
- 1996-09-09 AR ARP960104280A patent/AR004511A1/es unknown
- 1996-09-10 ZA ZA967631A patent/ZA967631B/xx unknown
- 1996-09-13 MY MYPI96003782A patent/MY116271A/en unknown
-
1997
- 1997-05-13 NO NO972186A patent/NO309527B1/no unknown
-
1999
- 1999-04-28 US US09/300,454 patent/US6114345A/en not_active Expired - Fee Related
-
2000
- 2000-04-26 GR GR20000400999T patent/GR3033315T3/el not_active IP Right Cessation
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